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Monk Fruit Extract: Zero-Calorie Sweetener, Surprising Benefits? Ep. 1241 MAY 2025A recent PRISMA-guided systematic review published in Nutrients synthesized findings from randomized controlled trials (RCTs) to assess the impact of monk fruit extract (MFE) on metabolic health, lipid profiles, inflammation, and regulatory considerations. The review included a number of RCTs (note: while some search results indicated 10, others mentioned 5 included studies; refer to the final published article for the definitive number). The findings indicate that MFE may help reduce postprandial glucose levels (by 10–18% in included studies) and insulin responses (by 12–22%). Some studies also reported reductions in inflammatory markers such as IL-6 and TNF-α. No severe adverse effects were observed in the reviewed trials. The review also notes that MFE is approved for use in the United States and China, with its status under review in the European Union. The authors suggest MFE shows potential as a functional food ingredient for metabolic health, though they highlight the need for long-term clinical trials and a harmonized regulatory framework to confirm its long-term safety and efficacy within sustainable health strategies. Disclaimers:"This information is for educational purposes only and should not be interpreted as medical advice.""This video discusses a systematic review of randomized controlled trials. While this represents a high level of evidence, individual results may vary, and further research is always ongoing.""Always consult with a qualified healthcare professional before making any changes to your diet, supplement regimen, or treatment plan, especially if you have a medical condition or are taking medications.""This channel does not provide medical advice."#MonkFruitExtract #MetabolicHealth #SystematicReview #RandomizedControlledTrials #SustainableHealthKaim U, Labus K. Monk Fruit Extract and Sustainable Health: A PRISMA-Guided Systematic Review of Randomized Controlled Trials. Nutrients. 2025; 17(9):1433. https://doi.org/10.3390/nu17091433Alchepharma,Ralph Turchiano,citation,research,study,Monk fruit extract,Siraitia grosvenorii,mogrosides,metabolic health,glycemic control,insulin response,inflammation,blood glucose,type 2 diabetes,natural sweeteners,low-calorie sweeteners,functional foods,dietary supplements,clinical trials,systematic review,PRISMA,nutritional science,dietary interventions,sugar substitutes,glucose metabolism,insulin sensitivity,inflammatory markers,regulatory status

Unlock the science behind Ashwagandha and stress! A pivotal 2023 systematic review published in Nutrients meticulously analyzed the current evidence on Withania somnifera's effect on the primary stress hormone, cortisol. By synthesizing data from nine clinical studies involving stressed human subjects, researchers investigated Ashwagandha's potential to modulate the hypothalamic-pituitary-adrenal (HPA) axis. The compelling finding? Supplementation with Ashwagandha for periods ranging from 30 to 112 days was consistently associated with significant reductions in cortisol levels, ranging from 11% to as much as 32.6%, compared to placebo groups. This review strongly suggests that short-term Ashwagandha use holds promise for buffering the physiological stress response in humans. However, the authors caution that dosages and formulations varied, and the long-term effects on adrenal function require further investigation.3. Disclaimers:"This information is for educational purposes only and should not be interpreted as medical advice.""This video discusses findings from a systematic review of studies conducted on stressed human subjects over short durations (30-112 days). Individual results can vary significantly based on dosage, formulation, duration of use, and individual health status. Long-term effects are not well established.""Always consult with a qualified healthcare professional before making any changes to your diet, supplement regimen, or treatment plan, especially if you have a medical condition (like thyroid disorders, autoimmune diseases, or hormone-sensitive conditions), are pregnant or breastfeeding, or are taking medications (such as immunosuppressants, sedatives, thyroid hormone, or medications for diabetes or high blood pressure).""This channel does not provide medical advice."#Ashwagandha #Cortisol #StressResponse #SystematicReview #AdaptogensDella Porta M, Maier JA, Cazzola R. Effects of Withania somnifera on Cortisol Levels in Stressed Human Subjects: A Systematic Review. Nutrients. 2023; 15(24):5015.

A 2024 randomized controlled trial published in the journal Nutrients investigated curcumin's effects on obese patients managing both type 2 diabetes and depression. The primary finding was a highly significant improvement in depression scores (measured by PHQ-9) for the group receiving curcumin compared to the placebo group over 12 months.Importantly, the positive benefits extended substantially beyond mood improvement. The study revealed several other markedly positive secondary outcomes in the curcumin group:Neurotransmitter Support: Significantly higher levels of serotonin (often linked to mood regulation).Reduced Inflammation: Significantly lower levels of key pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α).Enhanced Antioxidant Defense: Significantly increased total antioxidant status and activity of crucial antioxidant enzymes (glutathione peroxidase, superoxide dismutase).Lowered Oxidative Stress: Significantly lower levels of malondialdehyde, a marker of lipid peroxidation and oxidative damage.These impressive and wide-ranging results, demonstrating statistically significant positive effects across depression symptoms, neurotransmitter levels, inflammation, and oxidative stress pathways, suggest that curcumin supplementation shows considerable potential as a beneficial complementary strategy for this specific patient population dealing with the complex interplay of obesity, type 2 diabetes, and depression. Disclaimers:"This information is for educational purposes only and should not be interpreted as medical advice.""The study discussed was conducted on a specific population: obese adults with type 2 diabetes. These findings may not be generalizable to other populations or individuals with different health conditions.""Curcumin supplements can interact with various medications (like blood thinners or diabetes medications which might increase the risk of low blood sugar) and may not be appropriate for everyone. Always consult with a qualified healthcare professional before starting or stopping any supplement, including curcumin, or making changes to your treatment plan, especially if you have diabetes, depression, or any other medical condition.""This channel is not monetized and does not provide medical advice."#Curcumin #Depression #Type2Diabetes #Obesity #moodYaikwawong M, Jansarikit L, Jirawatnotai S, Chuengsamarn S. Curcumin Reduces Depression in Obese Patients with Type 2 Diabetes: A Randomized Controlled Trial. Nutrients. 2024; 16(15):2414. https://doi.org/10.3390/nu16152414Alchepharma,Ralph Turchiano,research,Curcumin,depression,type 2 diabetes,T2DM,obesity,metabolic syndrome,inflammation,oxidative stress,mental health,mood disorders,complementary therapy,turmeric,human study,obese patients,diabetic complications,glycemic control,insulin resistance,neuroinflammation,serotonin,interleukin,IL-6,TNF-alpha,dietary supplement,mental well-being,comorbid mood symptoms,diabetes management,alternative treatments,PHQ-9,biomarkers

A recent 12-week randomised controlled trial involving healthy adults aged 55-70 yielded significant positive findings regarding pomegranate extract's effect on blood pressure. While the study might not have shown significant differences compared to placebo across all initially measured markers, it revealed important reductions within the group taking pomegranate extract daily. Specifically, participants supplementing with pomegranate extract saw a statistically significant average decrease in Systolic Blood Pressure (SBP) by 5.22 mmHg and Diastolic Blood Pressure (DBP) by 3.6 mmHg. The researchers highlight the potential clinical relevance of the SBP reduction, noting that a 5 mmHg drop is associated with an estimated 10% decrease in the risk of major cardiovascular events. These findings align with previous research and meta-analyses confirming pomegranate's blood pressure-lowering effects, suggesting pomegranate extract could be a supportive strategy for hypertension prevention in older adults."This information is for educational purposes only and should not be interpreted as medical advice.""The study discussed was a randomised controlled trial in healthy adults aged 55-70.""The significant positive findings highlighted are the reductions in Systolic and Diastolic blood pressure observed within the group taking pomegranate extract. The authors note the SBP reduction is potentially clinically relevant.""These blood pressure findings are consistent with other studies and meta-analyses on pomegranate, strengthening the evidence for this specific effect.""Always consult with a qualified healthcare professional before making any changes to your diet, supplement regimen, or treatment plan, especially regarding blood pressure management or if you have existing health conditions or take medications.""This channel is not monetized and does not provide medical advice."#PomegranateExtract, #BloodPressure, #SystolicBloodPressure, #ClinicalRelevance, #HypertensionPreventionFarhat G, Malla J, Vadher J, Al-Dujaili EAS. Effects of Pomegranate Extract on Inflammatory Markers and Cardiometabolic Risk Factors in Adults Aged 55–70 Years: A Randomised Controlled Parallel Trial. Nutrients. 2025; 17(7):1235.

This video explores a comprehensive review published in the journal Nutrients focusing on Astragalus membranaceus and its potential role in delaying aging. What's fascinating is the breadth of mechanisms discussed: the review highlights how active phytochemicals in Astragalus root – like specific polysaccharides, flavonoids, and saponins – exert powerful antioxidant, anti-inflammatory, and immune-regulating effects. These properties are linked to protecting cells from damage and dysfunction associated with aging. The review specifically points to benefits for skin health, suggesting these compounds may help maintain skin condition and prevent tissue degeneration. Beyond the skin, the research surveyed indicates potential protective effects across multiple body systems – including the cardiovascular, nervous, and immune systems – painting a picture of Astragalus as a multifaceted agent in promoting healthspan and potentially slowing the aging process at a cellular level.Disclaimers:"This information is based on a scientific review article summarizing existing research and is for educational purposes only. It is not medical advice.""This review covers a range of studies (potentially including human, animal, and cell-based research). Consult the original review article for details on the sources of evidence. Further research is often needed.""Always consult a qualified healthcare professional before using Astragalus supplements or making changes to your health plan. Astragalus can interact with medications and may not be suitable for everyone, especially those with certain medical conditions.""This channel is not monetized and does not provide medical advice."#AstragalusMembranaceus #CellularAging #SkinAging #Astragalus #PhytochemicalsBorowicz KK, Jach ME. Astragalus Membranaceus—Can It Delay Cellular Aging? Nutrients. 2025; 17(8):1299. https://doi.org/10.3390/nu17081299Astragalus membranaceus,cellular aging,review,anti-aging,traditional Chinese medicine,antioxidants,flavonoids,saponins,polysaccharides,immunomodulation,inflammation,skin health,longevity,phytotherapy,herbal remedies,natural supplements,oxidative stress,senescence,gerontology,nutrients journal,adaptogen,cardiovascular health,immune support,regenerative medicine,systemic effects

This research overview explores nutritional approaches to combat muscle loss, also known as sarcopenia, a common age-related issue. The study emphasizes the critical role of diet in maintaining muscle health and strength. Key nutrients like protein, vitamin D, leucine, creatine, and HMB are discussed regarding their impact on muscle protein synthesis, directly affecting the progression of sarcopenia. The review highlights that personalized dietary strategies, tailored to individual needs, combined with exercise, are essential for effectively addressing muscle loss, mitigating sarcopenia, and improving overall physical functionDisclaimers:"This information is for educational purposes only and should not be interpreted as medical advice.""The information reviewed is based on research studies, and individual results may vary.""Always consult with a qualified healthcare professional or registered dietitian before making any changes to your diet or1 treatment plan, especially if you have a medical condition or are taking medications."#MuscleLoss #Sarcopenia #Nutrition #Protein #VitaminDMuscle loss, sarcopenia, muscle atrophy, aging, nutrition, protein intake, vitamin D, leucine, creatine, HMB, muscle health, elderly nutrition, dietary interventions, muscle strength, physical function, geriatric nutrition, muscle protein synthesis, sarcopenia treatment, muscle loss treatment, nutritional management, muscle mass, healthy aging, diet for muscle loss, muscle wasting, geriatric care, nutritional supplementsBarone M, Baccaro P, Molfino A. An Overview of Sarcopenia: Focusing on Nutritional Treatment Approaches. Nutrients. 2025; 17(7):1237. https://doi.org/10.3390/nu17071237

A recent review published in Nutrients explored the potential benefits of magnesium supplementation for migraine management. The research analyzed existing studies and found that magnesium may play a significant role in alleviating migraine symptoms. Specifically, the review indicates that magnesium can influence neurological pathways involved in migraine attacks, potentially reducing their frequency and severity. The review points to magnesium's ability to modulate neurotransmitter function and decrease neuronal excitability. The findings suggest that magnesium supplementation could be a valuable tool for individuals seeking natural migraine relief. While the review highlights promising benefits, further clinical trials are necessary to solidify these results and optimize magnesium dosage for migraine sufferers Disclaimers:"This information is for educational purposes only and should not be interpreted as medical advice.""This study is a review of existing literature, and further research, including clinical trials, is needed to confirm these findings.""Always consult with a qualified healthcare professional before starting any new supplement regimen, especially if you have a medical condition or are taking medications." "This channel does not provide medical advice."#MagnesiumMigraineRelief #MagnesiumBenefits #NaturalMigraineSupport #MigraineSupplement #MagnesiumForHeadachesDominguez LJ, Veronese N, Sabico S, Al-Daghri NM, Barbagallo M. Magnesium and Migraine. Nutrients. 2025; 17(4):725. https://doi.org/10.3390/nu17040725

This research explored the potential of Keyfobell Powder (KFB), a novel extract, to mimic the longitudinal bone growth effects of somatropin (human growth hormone) through the upregulation of IGF-1. KFB is composed of a mixture of Astragalus membranaceus water extract, red ginseng (Panax ginseng C.A. Meyer) 30% ethanolic extract, and Cervi Parvum Cornu 50% ethanolic extract, mixed in a ratio of 1:1.1:7.4. The study found that KFB supplementation significantly increased IGF-1 levels, leading to enhanced bone elongation in animal models. This suggests KFB may offer a natural alternative to somatropin, potentially with a reduced risk of side effects. While somatropin is effective for growth promotion, it can be associated with adverse effects. This study proposes that KFB, through its combination of Astragalus, red ginseng, and deer antler extract, could provide similar benefits by naturally stimulating IGF-1 production, thus promoting bone growth. It's crucial to acknowledge that this research was conducted on animal models, and human clinical trials are necessary to confirm these findings and assess the safety and efficacy of KFB as a somatropin alternativeDisclaimers:"This information is for educational purposes only and should not be interpreted as medical advice.""The study discussed was conducted on animal models. Further research is needed to confirm these findings in humans.""Always consult with a qualified healthcare professional before considering any growth hormone or growth-promoting alternatives, especially if you have a medical condition or are taking medications."#SomatropinAlternative #KeyfobellPowder #IGF1 #BoneGrowth #NaturalGrowthYouTube Channel ID: UCSxq36i1g2yb-GdmNq77U7wLee MJ, Jeong D, Lee JH, Kang J, Choi J, Seo J, Kim HI, Seo J, Ko K, Nam DH, et al. The Effects of a Novel Astragalus-Based Extract (Keyfobell Powder (KFB)) on Longitudinal Bone Growth via IGF-1 Upregulation: A Potential Growth Hormone Alternative. Nutrients. 2025; 17(3):416. https://doi.org/10.3390/nu17030416Alchepharma,Ralph Turchiano,citation,research,study,Somatropin,growth hormone,Astragalus membranaceus,Panax ginseng,Cervi Parvum Cornu,Keyfobell Powder,longitudinal bone growth,growth hormone alternative,natural growth hormone,bone elongation,skeletal growth,pediatric growth,growth disorders,growth hormone deficiency,clinical trials,bone density,cartilage growth,growth promotion,somatropin side effects,IGF-1 upregulation,phytotherapy,natural bone growth

4X Thicker Hair? Gynostemma pentaphyllum Clinical Trial Results Ep. 1233 MAR 2025A recent randomized, double-blind, placebo-controlled clinical trial published in Nutrients (2025) investigated the therapeutic potential of Gynostemma pentaphyllum extract for enhancing hair health. The study involved participants experiencing hair thinning. After 24 weeks, the Gynostemma pentaphyllum group showed a threefold increase in hair elasticity and density and a fourfold increase in hair diameter compared to the placebo group. Additionally, participants reported better outcomes in terms of reducing hair damage and dryness. These findings suggest that Gynostemma pentaphyllum extract may offer a natural and effective approach to promoting hair health. Disclaimers:"This information is for educational purposes only and should not be interpreted as medical advice.""The study discussed was conducted on a specific population experiencing hair thinning. Further research may be needed to confirm these findings in broader populations and to understand the long-term effects.""Always consult with a qualified healthcare professional before starting any new supplement or treatment regimen, especially if you have a medical condition or are taking medications.""This channel does not provide medical advice."Channel ID: UCSxq36i1g2yb-GdmNq77U7w#GynostemmaPentaphyllum #HairHealth #HairLoss #ClinicalTrial #NaturalRemediesLee J, Jin Y, Zhang X, Kim M, Koh A, Zhou S, Lee C, Seo M, Kim S, Jo S, et al. Therapeutic Potential of Gynostemma pentaphyllum Extract for Hair Health Enhancement: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Nutrients. 2025; 17(5):767. https://doi.org/10.3390/nu17050767Gynostemma pentaphyllum, jiaogulan, hair loss, hair growth, hair density, hair thickness, clinical trial, natural hair remedies, hair thinning, supplement, hair health, study results, randomized controlled trial, double-blind, placebo controlled, hair follicle count, hair shaft diameter, herbal remedies, nutrition, hair care, scalp health, androgenetic alopecia, alopecia, natural treatment, botanical extracts, nutrients, hair revitalization

This systematic review, published in Nutrients in 2025, examined the multifaceted health impacts of Yacon syrup, focusing on its role as a natural sweetener and its potential benefits for weight management and overall well-being. Yacon syrup, derived from the Yacon plant, is valued for its sweet taste and high content of fructooligosaccharides (FOS), which function as prebiotics. This review highlights several potential benefits: Yacon syrup can serve as a lower-calorie alternative to refined sugars, potentially aiding in weight management. Its FOS content promotes the growth of beneficial gut bacteria, contributing to a healthy gut microbiome. Additionally, some studies suggest potential positive impacts on glucose metabolism and lipid profiles, potentially benefiting individuals with metabolic concerns. The prebiotic effects may also contribute to improved satiety, assisting in calorie control. While these findings are promising, it's important to remember that more robust clinical trials are needed to solidify these results and understand the long-term effects of Yacon syrup. It should be used in moderation as part of a balanced diet and healthy lifestyle.Disclaimers:"This information is for educational purposes only and should not be interpreted as medical advice.""While Yacon syrup is a natural sweetener, it should still be consumed in moderation.""The weight loss effects of Yacon syrup are still under investigation, and results may vary.""Always consult with a qualified healthcare professional before making any changes to your diet or supplement regimen, especially if you have a medical condition or are taking medications." "This channel does not provide medical advice."(Remember to include a verbal disclaimer in the video.)#YaconSyrupSweetener #NaturalSweetener #WeightLossSweetener #HealthySweetener #PrebioticSweetenerPereira MF, Soares IdC, Cabral MM, de Freitas PA, Sousa GMA, Magalhães SC, Carioca AAF, de Oliveira MRC, Magalhães FEA, de Oliveira AC, et al. Impacts of Yacon Syrup (Smallanthus sonchifolius) on Human Health: A Systematic Review of Scientific Evidence from the Last Decade. Nutrients. 2025; 17(5):888. https://doi.org/10.3390/nu17050888Alchepharma,Ralph Turchiano,citation,research,study,Yacon syrup sweetener,natural sweeteners and weight loss,low-calorie sweeteners,prebiotic sweeteners,healthy sugar alternatives,Yacon syrup and sugar replacement,FOS sweeteners,weight management sweeteners,dietary sweeteners,sugar substitutes,blood sugar friendly sweeteners,natural sweeteners benefits,healthy dessert sweeteners,nutritional sweetening,alternative sweeteners,weight loss and sweet food

This research, a component of the larger DO-HEALTH trial, specifically examined the impact of vitamin D, omega-3 fatty acids, and exercise on DNA methylation clocks, indicators of biological aging, in a subset of approximately 777 older adults. While the broader DO-HEALTH trial included over 2,000 participants, this particular study focused on those with available DNA methylation data. The researchers found that a combined intervention of vitamin D, omega-3, and exercise led to a noticeable slowing of biological aging, as reflected in the DunedinPACE epigenetic clock. Although individual interventions also showed some positive trends, the combined approach demonstrated the most significant effect. This study highlights how targeted lifestyle interventions can potentially influence biological aging in older adults, based on analysis of a specific subset of the DO-HEALTH trial participants. Disclaimers:"This information is for educational purposes only and should not be interpreted as medical advice.""The study discussed was conducted on a subset of older adults from the DO-HEALTH trial. Further research may be needed to confirm these findings in other populations.""Always consult with a qualified healthcare professional before making any changes to your diet, supplement regimen, or exercise program, especially if you have a medical condition or are taking medications.""This channel does not provide medical advice."#BiologicalAging #VitaminD #Omega3 #Exercise #DNAMethylationBischoff-Ferrari, H.A., Gängler, S., Wieczorek, M. et al. Individual and additive effects of vitamin D, omega-3 and exercise on DNA methylation clocks of biological aging in older adults from the DO-HEALTH trial. Nat Aging (2025). https://doi.org/10.1038/s43587-024-00793-yBiological aging, DNA methylation, vitamin D, omega-3 fatty acids, exercise, older adults, DO-HEALTH trial, aging reversal, epigenetic clock, lifestyle interventions, healthy aging, cellular aging, gerontology, longevity, aging biomarkers, clinical trial, nutritional supplements, physical activity, epigenetic modifications, methylation patterns, aging research, preventative medicine, geriatrics, anti-aging strategies, molecular biology, healthspan.

This groundbreaking study has shed light on the potential of lycopene, a powerful antioxidant found in tomatoes, to combat depression-like behavior in mice subjected to chronic social defeat stress, a model for chronic stress. Researchers found that lycopene treatment significantly alleviated these behaviors. The study's key discovery centers around synaptic plasticity, the brain's ability to modify and strengthen connections between neurons, which is often impaired by stress. The research suggests that lycopene may exert its beneficial effects by enhancing synaptic plasticity, specifically through the BDNF-TrkB signaling pathway. This pathway is essential for neuronal growth, survival, and function, and plays a critical role in mood regulation. This breakthrough discovery linking lycopene, synaptic plasticity, and stress opens new avenues for depression research and potential treatment strategies. While these pre-clinical findings in mice are promising, further human studies are necessary to validate these results and explore the therapeutic potential of lycopene for depression.Disclaimers:"This information is for educational purposes only and should not be interpreted as medical advice.""The study discussed was conducted on mice. Further research, including human clinical trials, is needed to confirm these findings.""Always consult with a qualified healthcare professional before making any changes to your diet, supplement regimen, or treatment plan, especially if you have a medical condition or are taking medications.""This channel does not provide medical advice."#Lycopene #Depression #MentalHealth #BDNF #SynapticPlasticity #Neurobiology #PreclinicalResearch #MouseModel #ChronicSocialDefeatStress #Antioxidant #Breakthrough #StressResearchLycopene, depression, mental health, BDNF, synaptic plasticity, chronic social defeat stress, mouse model, antidepressant, natural remedies, carotenoid, brain health, neurobiology, TrkB pathway, mood regulation, behavioral study, preclinical research, lycopene benefits, dietary interventions, nutritional psychiatry, tomato benefits, antioxidant, brain function, neuroplasticity, synaptic strengthening, neuronal connections, animal model of depression, synaptic modulation, neurotrophic factors, stress, chronic stress, breakthrough researchZeng, Q., Gao, J., Liu, Y., Li, X., & Luo, J. (2023). Lycopene alleviates depression-like behavior in chronic social defeat stress-induced mice by promoting synaptic plasticity via the BDNF–TrkB pathway. Food Science and Nutrition, 11(1), 585–595. https://doi.org/10.1002/fsn3.70003

Hope for Heart Failure: New Research on Tricaprin Ep. 1229 FEB 2025This study explored the potential benefits of tricaprin, a natural supplement, for individuals with a specific, less common type of heart failure. This particular form of heart failure makes it difficult for the body to process certain fats. The research suggests that tricaprin may offer a promising approach for improving both survival rates and the overall health of the heart in these patients. The study followed a small group of patients who received tricaprin and compared their outcomes to a larger group who did not. Specifically, the study showed a 100% 3-year and 5-year survival rate for the patients receiving tricaprin, compared to 78.6% and 68.1% respectively for the control group. These results indicated that those taking tricaprin experienced significant improvements in long-term survival and heart function. While these findings are encouraging, it's important to remember that this research focused on a specific type of heart failure.Disclaimer:This information is for educational purposes only and should not be interpreted as medical advice.This study looked at a specific group of patients with a rare form of heart failure. More research is needed to see if these findings apply to other types of heart failure.Always talk to your doctor or other qualified healthcare provider before starting any new supplement or making changes to your treatment plan, especially if you have a heart condition.This channel does not provide medical advice.#HeartFailure #Tricaprin #NaturalHealth #HeartHealth #ResearchKen-ichi Hirano et al, Long-term survival and durable recovery of heart failure in patients with triglyceride deposit cardiomyovasculopathy treated with tricaprin, Nature Cardiovascular Research (2025). DOI: 10.1038/s44161-025-00611-7Tricaprin, heart failure, research, natural supplement, cardiac health, survival rates, clinical trial, heart condition, rare disease, potential treatment, promising results

A new study published in the journal Antioxidants investigated the effects of luteolin, a natural compound found in plants, on hair graying in mice. The researchers found that both external (topical) and internal (oral) administration of luteolin significantly reduced the number of gray hairs in the mice. The study also revealed that luteolin works by improving the signaling between cells involved in hair pigmentation, ultimately leading to a reduction in hair graying. These findings suggest that luteolin may be a promising natural treatment for hair graying in humans, although further research is needed to confirm these effects.3. Disclaimers:This information is for educational purposes only and should not be interpreted as medical advice.The study discussed was conducted on mice. Further research is needed to confirm these findings in humans.Always consult with a qualified healthcare professional before making any changes to your diet, supplement regimen, or treatment plan, especially if you have a medical condition or are taking medications.This channel does not provide medical advice.#Luteolin #GrayHair #HairLoss #Antioxidants #HairScienceLuteolin, gray hair, hair loss, hair graying, antioxidants, flavonoids, hair health, hair pigmentation, melanocytes, keratinocytes, stem cells, Ednrb, RET mice, study, research findings, natural treatment, hair care, hair growth, anti-aging

This research article investigated the effects of Brussels chicory on exercise performance and recovery in untrained college students. The study found that consuming Brussels chicory juice daily for 7 days increased time to exhaustion during high-intensity exercise by 8.3% in men and 12.2% in women. This improvement in performance was observed despite no significant changes in maximal oxygen consumption (VO2 max). Additionally, Brussels chicory consumption promoted post-exercise recovery, evidenced by a reduction in blood lactate levels by 14.5% in men and 10.6% in women. The study suggests that these improvements may be due to the promotion of lactate oxidation, a process that helps clear lactate from the muscles and improve acid-base balance Disclaimers: This information is for educational purposes only and should not be interpreted as medical advice. The study discussed was conducted on a specific population (untrained college students). Further research is needed to confirm these findings in other populations. Always consult with a qualified healthcare professional before making any changes to your diet or exercise plan, especially if you have a medical condition or are taking medications. This channel is not monetized and does not provide medical advice. #BrusselsChicory #ExercisePerformance #PostExerciseRecovery #LactateOxidation #SportsScience Mao Y, Huang J, Li S, Chen G, Du Y, Kang M, Zhu S, Zhang W, Xu Q, Wang Y, et al. Brussels Chicory Enhances Exhaustive Aerobic Exercise Performance and Post-Exercise Recovery, Possibly Through Promotion of Lactate Oxidation: A Pilot Randomized, Single-Blind, Placebo-Controlled, Two-Way Crossover Study. Nutrients. 2025; 17(2):365. https://doi.org/10.3390/nu17020365

A fascinating new study published in the journal Nutrients explored the impact of elderberry juice on metabolic health. Researchers had participants drink elderberry juice every day for one week, and the results were pretty amazing. They discovered that elderberry juice led to a significant 24% reduction in blood sugar levels after meals. This means the body became much better at regulating blood sugar, which is crucial for overall health and for people managing conditions like prediabetes or type 2 diabetes. But that's not all! The study also found a 27% increase in fat oxidation, meaning the body became more efficient at burning fat for energy. This could have exciting implications for weight management and metabolic health. While more research is needed to confirm these findings in larger populations, this study provides compelling evidence for the potential benefits of elderberry juice. Disclaimers: "This information is for educational purposes only and should not be interpreted as medical advice." "The study discussed was conducted on healthy adults. Further research is needed to confirm these findings in other populations and individuals with health conditions." "Always consult with a qualified healthcare professional before making any changes to your diet or lifestyle, especially if you have a medical condition or are taking medications." #ElderberryJuice #BloodSugar #FatBurning #Metabolism #WeightLoss Teets C, Ghanem N, Ma G, Minj J, Perkins-Veazie P, Johnson SA, Etter AJ, Carbonero FG, Solverson PM. A One-Week Elderberry Juice Intervention Augments the Fecal Microbiota and Suggests Improvement in Glucose Tolerance and Fat Oxidation in a Randomized Controlled Trial. Nutrients. 2024; 16(20):3555. https://doi.org/10.3390/nu16203555 elderberry juice, blood sugar, glucose, insulin, fat burning, weight loss, metabolism, metabolic health, study, research, science, health benefits, healthy living, natural remedies, type 2 diabetes, prediabetes, gut health, antioxidants

A recent study published in the journal Nutrients investigated the effects of Weizmannia coagulans BC99 on strength performance and muscle quality in a group of male college students majoring in physical education. These students were likely already engaged in regular physical activity, making them a good test group for this type of supplement. Here's what the researchers found: Significant Improvement in Strength: Participants who took BC99 showed a marked increase in their strength performance across various exercises. This suggests that BC99 could help athletes and fitness enthusiasts achieve new levels of strength. Enhanced Muscle Growth: The study also revealed that BC99 supplementation led to an increase in skeletal muscle mass. This finding indicates that BC99 may play a role in promoting muscle growth and development. Improved Protein Digestion: Researchers observed that BC99 enhanced protein digestion in the participants. This is important because efficient protein digestion is crucial for muscle building and recovery. Regulation of Muscle Quality: BC99 appeared to positively influence hormones related to muscle growth and repair, suggesting a potential role in improving overall muscle quality. This study provides compelling evidence that Weizmannia coagulans BC99 could be a valuable supplement for those seeking to enhance their strength and muscle health. However, it's important to remember that more research is needed, especially in diverse populations. 3. Disclaimers: "The information presented in this video is intended for educational purposes only and does not constitute medical advice. Always consult with a qualified healthcare professional before starting any new supplement regimen, especially if you have underlying health conditions or are taking medications. "The study discussed was conducted on young, healthy male college students. Further research is needed to determine if these findings apply to other populations, including women, older adults, and individuals with different health backgrounds." "This channel is not monetized and does not endorse any specific products or brands. Any mention of supplements is for informational purposes only." #WeizmanniaCoagulans #BC99 #StrengthTraining #MuscleGrowth #SportsNutrition #Supplements #Fitness #AthleticPerformance #HealthAndWellness #ResearchUpdate Cao L, Guo M, Zhou Y, Zhang J, Tie S, Li X, Tian P, Wu Y, Gu S. Weizmannia coagulans BC99 Improves Strength Performance by Enhancing Protein Digestion and Regulating Skeletal Muscle Quality in College Students of Physical Education Major. Nutrients. 2024; 16(23):3990. https://doi.org/10.3390/nu16233990 Weizmannia coagulans BC99, strength training, muscle growth, athletic performance, sports nutrition, supplements, probiotics, gut health, protein digestion, amino acids, muscle protein synthesis, testosterone, growth hormone, exercise physiology, clinical trial, research study, health and wellness, fitness enthusiasts, athletes, dietary supplements, nutritional strategies

A groundbreaking 2025 systematic review and meta-analysis published in Nutrients investigated the effects of maca (Lepidium meyenii) on physical performance in both animals and humans. This comprehensive review analyzed numerous studies, finding compelling evidence that maca supplementation can significantly enhance various aspects of physical performance, including endurance, strength, and speed. These findings have exciting implications for athletes and anyone seeking to optimize their physical capabilities. Disclaimers: "This information is for educational purposes only and should not be interpreted as medical advice." "The studies discussed in this review were conducted on both animals and humans. Further research may be needed to confirm these findings and explore optimal dosages and long-term effects." "Always consult with a qualified healthcare professional before taking maca or any new supplement, especially if you have a medical condition or are taking medications." #Maca #Superfoods #Fitness #Workout #EnergyBoost Huerta Ojeda Á, Rodríguez Rojas J, Cancino-López J, Barahona-Fuentes G, Pavez L, Yeomans-Cabrera M-M, Jorquera-Aguilera C. Effects of Maca (Lepidium meyenii Walp.) on Physical Performance in Animals and Humans: A Systematic Review and Meta-Analysis. Nutrients. 2025; 17(1):107. https://doi.org/10.3390/nu17010107 Maca, Lepidium meyenii, performance enhancement, athletic performance, endurance, stamina, strength training, muscle growth, fatigue reduction, speed, agility, power output, VO2 max, lactate threshold, muscle damage, recovery time, energy metabolism, hormonal balance, cortisol, antioxidant status, oxidative stress, inflammation, mood, cognition, sleep quality

This new research in Nutrients has exciting news for female athletes! Beetroot juice was shown to significantly improve VO2 max by 4.82%. That's a big deal because VO2 max is a key indicator of aerobic fitness and endurance. But that's not all – the study also found that beetroot juice enhanced breathing efficiency, meaning athletes could use oxygen more effectively during exercise. This combination of benefits could lead to significant improvements in performance. 3. Disclaimers: "This information is for educational purposes only and should not be interpreted as medical advice." "The study discussed was conducted on a specific group of female athletes. Further research is needed to confirm these findings in larger and more diverse populations." "Always consult with a qualified healthcare professional before making any changes to your diet or supplement regimen, especially if you have a medical condition or are taking medications." "This channel does not provide medical advice." #BeetrootJuice #VO2Max #FemaleAthletes #SportsPerformance #EnduranceTraining

A recent study investigated the effects of Salvia miltiorrhiza root extract (Danshen, also known as red sage), at two different dosages (400 mg/day and 800 mg/day), on men with lower urinary tract symptoms (LUTS). The randomized, double-blind, placebo-controlled trial involved 136 male participants. The study found that Danshen, at both dosages, significantly improved LUTS compared to a placebo. This improvement was observed in various aspects of urinary health, including nighttime urination frequency and quality of life. These findings suggest that Danshen may be a promising natural approach for managing LUTS in men. 3. Disclaimers: • "This information is for educational purposes only and should not be interpreted as medical advice." • "The study discussed was conducted on a specific population (adult males with LUTS). Further research is needed to confirm these findings in other populations." • "Always consult with a qualified healthcare professional before taking any new supplement, especially if you have a medical condition or are taking medications." #redsage #danshen #Salvia_miltiorrhiza #BPH #prostatehealth #LUTS Liu, Z.; Wang, W.; Li, C.; Liu, Y.; Qin, X.; Sun, H.; Wang, X.; Wang, C.; Hu, T. A Randomized, Double-Blind, Placebo-Controlled Trial of Salvia miltiorrhiza Extract in the Treatment of Lower Urinary Tract Symptoms in Men. Nutrients 2024, 17, 24. https://doi.org/10.3390/nu17010024 Alchepharma,Ralph Turchiano,citation,research,study,Salvia miltiorrhiza,Danshen,red sage,red root sage,Tan Shen,Chinese sage,lower urinary tract symptoms,LUTS,men's health,prostate health,benign prostatic hyperplasia,BPH,enlarged prostate,nocturia,frequent urination at night,urinary frequency,urgency,weak stream,quality of life,natural remedies,herbal remedies,TCM,clinical trial,research study,prostate supplements,urinary health supplements

Alpha-Ketoglutarate (AKG) is a naturally occurring compound found in the body with a growing list of potential health benefits. While it's been studied for its role in muscle health and exercise performance, research suggests AKG may also offer anti-aging properties, immune system support, and wound healing benefits. AKG is involved in various metabolic processes, including energy production and amino acid synthesis. As we age, AKG levels decline, which may contribute to age-related health issues. Supplementing with AKG could potentially slow down aging processes, boost immunity, and improve overall healthspan. #AlphaKetoglutarate #MuscleProteinSynthesis #AntiCatabolic #MuscleHypertrophy #AKG Xu M, Zhang Q, Liu X, Lu L, Li Z. Impact of Alpha-Ketoglutarate on Skeletal Muscle Health and Exercise Performance: A Narrative Review. Nutrients. 2024; 16(22):3968. https://doi.org/10.3390/nu16223968 Alpha-Ketoglutarate, AKG, anti-aging, longevity, healthspan, immune system, immunity, wound healing, metabolism, amino acid synthesis, Krebs cycle, NAD+ metabolism, oxidative stress, inflammation, lifespan, age-related decline, supplementation, health benefits, clinical trials, cell function, collagen synthesis, gut health, bone health --- Support this podcast: https://podcasters.spotify.com/pod/show/ralph-turchiano/support

This study explored the effects of elderberry extract on testosterone levels in rats experiencing testosterone deficiency syndrome (TDS). The researchers focused on how elderberry extract affected key enzymes involved in testosterone production and metabolism. They found that the extract increased total testosterone levels by 113.4% in the low-dose group, 219.3% in the mid-dose group, and 267.1% in the high-dose group compared to the control group. 1 Importantly, the high-dose group's testosterone levels were restored to levels similar to those of young rats. 2 The extract also increased free testosterone (the active form that's not bound to proteins) and improved sperm motility. 3 Furthermore, the researchers found no negative effects on prostate health, liver function, or kidney function, suggesting that elderberry extract could be a safe and effective natural approach for managing testosterone deficiency. #elderberry #testosterone #menshealth #hormones #naturalremedies #supplements #diet #aging #testosteronedeficiency #lowtestosterone #malehormones #andropause #fertility #libido #energy #moodenhancing #sambucus Kim J, An J, Song Y, Jang M, Kong H, Kim S. Effect of Elderberry (Sambucus nigra L.) Extract Intake on Normalizing Testosterone Concentration in Testosterone Deficiency Syndrome Rat Model Through Regulation of 17β-HSD, 5α-Reductase, and CYP19A1 Expression. Nutrients. 2024; 16(23):4169. https://doi.org/10.3390/nu16234169 --- Support this podcast: https://podcasters.spotify.com/pod/show/ralph-turchiano/support

A recent study, the PPaX trial, has shown promising results in preventing preterm birth. By simply chewing xylitol gum twice daily, pregnant women in Malawi experienced a significant reduction in preterm births. The study, involving over 10,000 women, found that those who chewed xylitol gum had a 24% lower risk of preterm birth and a 30% lower risk of low birth weight compared to those who did not. This simple intervention could have a profound impact on global maternal and infant health, particularly in regions with limited access to advanced healthcare. #xylitol #xylitolgum #maternalhealth #preganancy Valentine et al., A cluster randomized trial of xylitol chewing gum for prevention of preterm birth: The PPaX trial, Med (2024), https://doi.org/10.1016/j.medj.2024.10.016 Alchepharma,Ralph Turchiano,citation,research,study,preterm birth,xylitol,gum,xylitol gum,oral health,periodontal disease,pregnancy complications,maternal health,infant mortality,randomized controlled trial,cluster randomized trial,public health intervention,low birth weight,oral microbiota,inflammation,immune response,oxidative stress,nutritional intervention,global health,developing countries,healthcare disparities,cost-effective interventions --- Support this podcast: https://podcasters.spotify.com/pod/show/ralph-turchiano/support

A recent study published in the Journal of Functional Foods delved into the impact of kimchi consumption on body composition. Researchers conducted a randomized, double-blind, placebo-controlled trial, where participants were assigned to either a kimchi or placebo group. After a specific period of kimchi or placebo consumption, the kimchi group exhibited a significant reduction in body fat compared to the placebo group. This suggests that regular kimchi consumption may contribute to weight loss and improved body composition. #kimchi #bodyfat #weightloss #metabolism #Leuconostocmesenteroides Wooje Lee, Min-Sung Kwon, Ye-Rang Yun, et al. (2024) Effects of kimchi consumption on body fat and intestinal microbiota in overweight participants: A randomized, double-blind, placebo-controlled, single-center clinical trial, Journal of Functional Foods. doi:https://doi.org/10.1016/j.jff.2024.106401. https://www.sciencedirect.com/science/article/pii/S1756464624004031 Alchepharma,Ralph Turchiano,citation,research,study,kimchi,gut microbiota,obesity,weight loss,body composition,probiotics,prebiotics,kimchi starter,fermented foods,metabolic health,inflammatory bowel disease,irritable bowel syndrome,digestive health,microbiome,microbiome diversity,short-chain fatty acids,SCFAs,Leuconostoc mesenteroides,mental health,Korean food,Asian diet,nutrition research,clinical trial,randomized controlled trial,Akkermansia muciniphila --- Support this podcast: https://podcasters.spotify.com/pod/show/ralph-turchiano/support

Recent research has shown promising results for using kimchi and cheonggukjang probiotics to combat hair loss. In a clinical study, participants experienced a significant increase in hair count and thickness after just one month of consuming a probiotic product derived from these traditional Korean foods. This suggests that the probiotics may stimulate hair growth by promoting the anagen phase, the active growth phase of the hair cycle. While further research is needed, these findings offer a potential natural solution for those struggling with hair loss. Park, S. Y., Lee, J. H., Park, J. H., Lee, M. K., Kim, H. J., & Kim, H. J. (2019). Do Kimchi and Cheonggukjang Probiotics as a Functional Food Improve Androgenetic Alopecia? A Clinical Pilot Study. Journal of Microbiology and Biotechnology, 29(1), 1-8. #kimchi #cheonggukjang #probiotics #hairgrowth kimchi, cheonggukjang, probiotics, functional food, androgenetic alopecia, hair loss, hair growth, hair count, hair thickness, 5-α reductase, DHT, scalp circulation, anagen phase, hair follicle, microbial strategy, nutritional strategy, Korean food, fermented food, gut health, skin health, clinical trial, pilot study, scientific research, medical research --- Support this podcast: https://podcasters.spotify.com/pod/show/ralph-turchiano/support

Recent scientific research suggests that jujube seeds, a traditional Chinese medicine, may hold the key to natural brain regeneration. Studies have shown that consuming jujube seeds can improve cognitive function, reduce inflammation in the brain, and even reverse some of the damage caused by neurodegenerative diseases. While more research is needed to fully understand the mechanisms behind these effects, jujube seeds offer a promising natural approach to promoting brain health and potentially reversing age-related cognitive decline. #jujubesseds #dementia #brainhealth Umeda Tomohiro, Sakai Ayumi, Uekado Rumi, Shigemori Keiko, Nakajima Ryota, Yamana Kei, Tomiyama Takami (2024) Simply crushed Zizyphi spinosi semen prevents neurodegenerative diseases and reverses age-related cognitive decline in mice eLife 13:RP100737 https://doi.org/10.7554/eLife.100737.1 Ziziphus jujuba, jujube seeds, brain regeneration, neurogenesis, neuroprotection, cognitive function, memory impairment, Alzheimer's disease, dementia, Parkinson's disease, oxidative stress, inflammation, neuroinflammation, antioxidant, polyphenol, triterpenoid, flavonoid, animal model, mouse model, in vitro study, cell culture, neuronal differentiation, synaptic plasticity, neurotrophic factor, traditional Chinese medicine --- Support this podcast: https://podcasters.spotify.com/pod/show/ralph-turchiano/support

Lemon balm (Melissa officinalis L.) has garnered significant attention for its potential to promote psychological well-being. Research suggests that this herb may exert anxiolytic and antidepressant effects, improve sleep quality, and enhance cognitive function. These benefits are attributed to its diverse phytochemical profile, including compounds like rosmarinic acid, citral, and terpenes. While further rigorous clinical trials are needed, preliminary studies indicate that lemon balm may offer a safe and effective non-pharmacological approach for managing mild to moderate psychological concerns. #LemonBalm #mood #anxiety Mathews IM, Eastwood J, Lamport DJ, Cozannet RL, Fanca-Berthon P, Williams CM. Clinical Efficacy and Tolerability of Lemon Balm (Melissa officinalis L.) in Psychological Well-Being: A Review. Nutrients. 2024; 16(20):3545. https://doi.org/10.3390/nu16203545 Alchepharma,Ralph Turchiano,citation,research,study,Melissa officinalis,lemon balm,herbal medicine,phytotherapy,anxiolytic,antidepressant,cognitive enhancement,sleep disorders,stress reduction,GABAergic system,cholinergic system,serotonergic system,neurotransmitter,phytochemical,rosmarinic acid,citral,clinical trial,randomized controlled trial (RCT),placebo-controlled trial,psychological well-being,mental health,quality of life,herbal supplement --- Support this podcast: https://podcasters.spotify.com/pod/show/ralph-turchiano/support

Pistachios Boost Eye Health: Study Ep. 1213 OCT 2024 A recent study has revealed that incorporating pistachios into your diet could offer significant benefits for your eye health. Researchers discovered that regular pistachio consumption can increase macular pigment optical density, a vital component of the macula, the central part of the retina responsible for sharp, detailed vision. This increase in macular pigment density is linked to a reduced risk of age-related macular degeneration, a leading cause of vision loss in older adults. By understanding the potential positive impact of pistachios on eye health, individuals can make informed choices about their diet and take proactive steps to protect their vision #pistachios #mpod #amd #pigment #nightvision Scott, T. M., Ogunbodede, O., McKay, D., & Johnson, E. J. (2024). Pistachio consumption increases macular pigment optical density in healthy adults: A randomized controlled trial. The Journal of Nutrition , [Publish Ahead of Print]. https://doi.org/10.1016/j.tjnut.2024.10.022 --- Support this podcast: https://podcasters.spotify.com/pod/show/ralph-turchiano/support

A groundbreaking new study has revealed a startling connection between extra virgin olive oil and mortality. Researchers in South Italy discovered that individuals who regularly consumed EVOO were significantly less likely to die prematurely, especially those battling non-alcoholic fatty liver disease. This astonishing finding sheds new light on the incredible power of dietary choices and could revolutionize our understanding of longevity and health. #oliveoil #health #mortality #study #NAFLD --- Support this podcast: https://podcasters.spotify.com/pod/show/ralph-turchiano/support

"This video delves into the fascinating world of cranberry juice and its potential benefits for skin health. A recent randomized controlled trial explored the effects of a polyphenol-rich cranberry beverage on various aspects of skin health in women. The results revealed that regular consumption of this cranberry drink positively impacted skin lipids, skin microbiome, inflammation, and oxidative stress. Discover how this natural beverage could contribute to healthier, more radiant skin." #cranberry #cranberryjuice #wrinkles #skinhealth #antiaging Christman L, De Benedetto A, Johnson E, Khoo C, Gu L. Polyphenol-Rich Cranberry Beverage Positively Affected Skin Health, Skin Lipids, Skin Microbiome, Inflammation, and Oxidative Stress in Women in a Randomized Controlled Trial. Nutrients. 2024; 16(18):3126. https://doi.org/10.3390/nu16183126 skin, cranberry, juice, aging, wrinkles, antioxidants, collagen, elastin, elasticity, firmness, texture, fine lines, wrinkles, sagging, premature aging, photoaging, sun damage, UV rays, free radicals, oxidative stress, inflammation, microbiome, skin barrier, hydration, moisture, youthful, radiant, glowing, natural, beverage, nutrition, dermatology, clinical, research --- Support this podcast: https://podcasters.spotify.com/pod/show/ralph-turchiano/support

This video delves into the potential benefits of creatine supplementation for firefighters, tactical athletes, and warfighters. Based on a comprehensive review of scientific literature, we explore the physiological mechanisms underlying creatine's effects on muscle strength, power, and endurance. By examining the unique physical demands of these professions, we discuss how creatine supplementation may enhance performance, reduce fatigue, and improve overall physical fitness. We also address potential safety concerns and provide recommendations for proper creatine dosage and supplementation strategies. #creatine #creatinebenefits #creatinesupplementation #creatineperformance #creatineresearch Gonzalez DE, Forbes SC, Zapp A, Jagim A, Luedke J, Dickerson BL, Root A, Gil A, Johnson SE, Coles M, et al. Fueling the Firefighter and Tactical Athlete with Creatine: A Narrative Review of a Key Nutrient for Public Safety. Nutrients. 2024; 16(19):3285. https://doi.org/10.3390/nu16193285 Alchepharma,Ralph Turchiano,citation,research,study,creatine,creatine supplementation,creatine benefits,muscle strength,muscle power,muscle endurance,athletic performance,firefighter performance,tactical athlete performance,warfighter performance,creatine for athletes,creatine for strength training,creatine for weightlifting,creatine for military personnel,creatine for law enforcement,creatine for first responders,creatine research,creatine studies --- Support this podcast: https://podcasters.spotify.com/pod/show/ralph-turchiano/support

This is a research paper about sports supplements and the effects of five different supplements on athletic performance. The five supplements studied are creatine, beta-alanine, nitrates, caffeine, and protein. The article discusses how creatine increases muscle strength and power, beta-alanine reduces fatigue during exercise, nitrates improve endurance, caffeine reduces pain and improves focus, and protein helps muscles grow and recover. #sportsupplements #athleticperformance #creatine #betaalanine #nitrates Antonio J, Pereira F, Curtis J, Rojas J, Evans C. The Top 5 Can't-Miss Sport Supplements. Nutrients. 2024; 16(19):3247. https://doi.org/10.3390/nu16193247 sports supplements, athletic performance, creatine, beta-alanine, nitrates, caffeine, protein, muscle strength, power, fatigue, endurance, pain, focus, muscle growth, recovery, exercise, supplements, nutrition, fitness, workout, health, bodybuilding, weightlifting, sports, athletes --- Support this podcast: https://podcasters.spotify.com/pod/show/ralph-turchiano/support

"This study investigates the potential of blackcurrant supplementation to mitigate postmenopausal bone loss. Previous research has demonstrated the beneficial effects of blackcurrants on bone health in animal models. In this randomized controlled trial, we examined the impact of blackcurrant supplementation on whole-body bone mineral density in peri- and early post-menopausal women. Our findings suggest that blackcurrant supplementation can effectively prevent bone loss and may even promote bone gain in this population. These results highlight the potential of dietary interventions to address the health challenges associated with menopause." #Blackcurrants #BoneHealth #PostmenopausalOsteoporosis #GutMicrobiome #NaturalRemedies Nosal BM, Thornton SN, Darooghegi Mofrad M, Sakaki JR, Mahoney KJ, Macdonald Z, Daddi L, Tran TDB, Weinstock G, Zhou Y, Lee EC, Chun OK. Blackcurrants shape gut microbiota profile and reduce risk of postmenopausal osteoporosis via the gut-bone axis: Evidence from a pilot randomized controlled trial. J Nutr Biochem. 2024 Nov;133:109701. doi: 10.1016/j.jnutbio.2024.109701. Epub 2024 Jul 15. PMID: 39019119. --- Support this podcast: https://podcasters.spotify.com/pod/show/ralph-turchiano/support

"This study investigates the potential of blackcurrant supplementation to mitigate postmenopausal bone loss. Previous research has demonstrated the beneficial effects of blackcurrants on bone health in animal models. In this randomized controlled trial, we examined the impact of blackcurrant supplementation on whole-body bone mineral density in peri- and early post-menopausal women. Our findings suggest that blackcurrant supplementation can effectively prevent bone loss and may even promote bone gain in this population. These results highlight the potential of dietary interventions to address the health challenges associated with menopause." #Blackcurrants #BoneHealth #PostmenopausalOsteoporosis #GutMicrobiome #NaturalRemedies Nosal BM, Thornton SN, Darooghegi Mofrad M, Sakaki JR, Mahoney KJ, Macdonald Z, Daddi L, Tran TDB, Weinstock G, Zhou Y, Lee EC, Chun OK. Blackcurrants shape gut microbiota profile and reduce risk of postmenopausal osteoporosis via the gut-bone axis: Evidence from a pilot randomized controlled trial. J Nutr Biochem. 2024 Nov;133:109701. doi: 10.1016/j.jnutbio.2024.109701. Epub 2024 Jul 15. PMID: 39019119. --- Support this podcast: https://podcasters.spotify.com/pod/show/ralph-turchiano/support

This video presents a compelling case for the efficacy of hypertonic saline nasal drops in mitigating the symptoms and duration of the common cold in young children. A recent randomized controlled trial, presented at the European Respiratory Society Congress, demonstrated that the use of saline drops significantly reduced the overall duration of illness compared to conventional care. The underlying mechanism, involving the enhancement of cellular defense mechanisms, is explained in detail. Additionally, the potential for reducing the transmission of the cold virus to family members is highlighted. This video offers valuable insights for parents seeking safe and effective strategies to manage their children's respiratory health. #hypertonic_saline_nasal_drops #common_cold #salinesolution #saltwater #cold [1] Abstract no: OA1985 “A randomised controlled trial of hypertonic saline nose drops as a treatment in children with the common cold (ELVIS-Kids trial)”, by Dr Sandeep Ramalingam et al; Presented in session “Advancements in paediatric infectious respiratory health” at 15:45–17:00 CEST on Sunday 8 September 2024. hypertonic saline nasal drops, common cold, pediatric health, child health, natural remedies, randomized controlled trial, clinical research, public health, evidence-based medicine, pediatric respiratory health, ELVIS-Kids trial, European Respiratory Society, ERS Congress, saltwater nose drops, child health research, cold symptoms, viral replication, immune system, nasal congestion, sinusitis, upper respiratory infection, antiviral therapy, pediatrics, health care, medical research, health science --- Support this podcast: https://podcasters.spotify.com/pod/show/ralph-turchiano/support

This video presents a compelling case for the efficacy of hypertonic saline nasal drops in mitigating the symptoms and duration of the common cold in young children. A recent randomized controlled trial, presented at the European Respiratory Society Congress, demonstrated that the use of saline drops significantly reduced the overall duration of illness compared to conventional care. The underlying mechanism, involving the enhancement of cellular defense mechanisms, is explained in detail. Additionally, the potential for reducing the transmission of the cold virus to family members is highlighted. This video offers valuable insights for parents seeking safe and effective strategies to manage their children's respiratory health. #hypertonic_saline_nasal_drops #common_cold #salinesolution #saltwater #cold [1] Abstract no: OA1985 “A randomised controlled trial of hypertonic saline nose drops as a treatment in children with the common cold (ELVIS-Kids trial)”, by Dr Sandeep Ramalingam et al; Presented in session “Advancements in paediatric infectious respiratory health” at 15:45–17:00 CEST on Sunday 8 September 2024. hypertonic saline nasal drops, common cold, pediatric health, child health, natural remedies, randomized controlled trial, clinical research, public health, evidence-based medicine, pediatric respiratory health, ELVIS-Kids trial, European Respiratory Society, ERS Congress, saltwater nose drops, child health research, cold symptoms, viral replication, immune system, nasal congestion, sinusitis, upper respiratory infection, antiviral therapy, pediatrics, health care, medical research, health science --- Support this podcast: https://podcasters.spotify.com/pod/show/ralph-turchiano/support

This video presents a compelling case for the efficacy of hypertonic saline nasal drops in mitigating the symptoms and duration of the common cold in young children. A recent randomized controlled trial, presented at the European Respiratory Society Congress, demonstrated that the use of saline drops significantly reduced the overall duration of illness compared to conventional care. The underlying mechanism, involving the enhancement of cellular defense mechanisms, is explained in detail. Additionally, the potential for reducing the transmission of the cold virus to family members is highlighted. This video offers valuable insights for parents seeking safe and effective strategies to manage their children's respiratory health. #hypertonic_saline_nasal_drops #common_cold #salinesolution #saltwater #cold [1] Abstract no: OA1985 “A randomised controlled trial of hypertonic saline nose drops as a treatment in children with the common cold (ELVIS-Kids trial)”, by Dr Sandeep Ramalingam et al; Presented in session “Advancements in paediatric infectious respiratory health” at 15:45–17:00 CEST on Sunday 8 September 2024. hypertonic saline nasal drops, common cold, pediatric health, child health, natural remedies, randomized controlled trial, clinical research, public health, evidence-based medicine, pediatric respiratory health, ELVIS-Kids trial, European Respiratory Society, ERS Congress, saltwater nose drops, child health research, cold symptoms, viral replication, immune system, nasal congestion, sinusitis, upper respiratory infection, antiviral therapy, pediatrics, health care, medical research, health science --- Support this podcast: https://podcasters.spotify.com/pod/show/ralph-turchiano/support

The Liver-Healthy Benefits of Camu-Camu Ep. 1206 SEP 2024 Recent research suggests that camu-camu, a vibrant Amazonian fruit packed with antioxidants, may offer significant benefits for liver health. Studies have shown that camu-camu consumption can help reduce hepatic steatosis and improve liver function markers, particularly in individuals with excess weight and high triglycerides. #CamuCamu #HepaticSteatosis #LiverHealth #AST #ALT Agrinier AL, Morissette A, Daoust L, Gignac T, Marois J, Varin TV, Pilon G, Larose É, Gagnon C, Desjardins Y, Anhê FF, Carreau AM, Vohl MC, Marette A. Camu-camu decreases hepatic steatosis and liver injury markers in overweight, hypertriglyceridemic individuals: A randomized crossover trial. Cell Rep Med. 2024 Aug 20;5(8):101682. doi: 10.1016/j.xcrm.2024.101682. PMID: 39168095. liver health, camu-camu, camu camu, hepatic steatosis, antioxidants, natural remedies, weight management, hypertriglyceridemia, metabolic health, non-alcoholic fatty liver disease (NAFLD), cirrhosis, liver injury markers, liver function, dietary supplements, nutrition, health science, medical research, clinical trials, randomized controlled trials, systematic reviews, meta-analyses --- Support this podcast: https://podcasters.spotify.com/pod/show/ralph-turchiano/support

The Liver-Healthy Benefits of Camu-Camu Ep. 1206 SEP 2024 Recent research suggests that camu-camu, a vibrant Amazonian fruit packed with antioxidants, may offer significant benefits for liver health. Studies have shown that camu-camu consumption can help reduce hepatic steatosis and improve liver function markers, particularly in individuals with excess weight and high triglycerides. #CamuCamu #HepaticSteatosis #LiverHealth #AST #ALT Agrinier AL, Morissette A, Daoust L, Gignac T, Marois J, Varin TV, Pilon G, Larose É, Gagnon C, Desjardins Y, Anhê FF, Carreau AM, Vohl MC, Marette A. Camu-camu decreases hepatic steatosis and liver injury markers in overweight, hypertriglyceridemic individuals: A randomized crossover trial. Cell Rep Med. 2024 Aug 20;5(8):101682. doi: 10.1016/j.xcrm.2024.101682. PMID: 39168095. liver health, camu-camu, camu camu, hepatic steatosis, antioxidants, natural remedies, weight management, hypertriglyceridemia, metabolic health, non-alcoholic fatty liver disease (NAFLD), cirrhosis, liver injury markers, liver function, dietary supplements, nutrition, health science, medical research, clinical trials, randomized controlled trials, systematic reviews, meta-analyses --- Support this podcast: https://podcasters.spotify.com/pod/show/ralph-turchiano/support

This study explores the science behind coffee and body composition. Researchers compared lightly roasted coffee to regular roasted coffee and found that both can help reduce body fat. But there's a twist: lightly roasted coffee might be even more effective! Tune in to find out why and get motivated to brew your next cup. #coffee #fitness #fitness #regularroastcoffee #bodycomposition #coffeetime Fernández-Cardero Á, Sierra-Cinos JL, Bravo L, Sarriá B. Consumption of a Coffee Rich in Phenolic Compounds May Improve the Body Composition of People with Overweight or Obesity: Preliminary Insights from a Randomized, Controlled and Blind Crossover Study. Nutrients. 2024; 16(17):2848. https://doi.org/10.3390/nu16172848 coffee, roast level, weight loss, body composition, fat mass, body fat percentage, lightly roasted coffee, regular roasted coffee, middle-aged adults, overweight, obesity, caffeine, antioxidants, metabolism, thermogenesis, gut health, microbiome, inflammation, blood sugar, insulin, blood pressure, cholesterol, heart health, weight management, healthy lifestyle, coffee consumption, scientific research, health benefits --- Support this podcast: https://podcasters.spotify.com/pod/show/ralph-turchiano/support

Roast Matters: Coffee and Body Fat Ep. 1205 SEP 2024 This study explores the science behind coffee and body composition. Researchers compared lightly roasted coffee to regular roasted coffee and found that both can help reduce body fat. But there's a twist: lightly roasted coffee might be even more effective! Tune in to find out why and get motivated to brew your next cup. #coffee #fitness #fitness #regularroastcoffee #bodycomposition #coffeetime Fernández-Cardero Á, Sierra-Cinos JL, Bravo L, Sarriá B. Consumption of a Coffee Rich in Phenolic Compounds May Improve the Body Composition of People with Overweight or Obesity: Preliminary Insights from a Randomized, Controlled and Blind Crossover Study. Nutrients. 2024; 16(17):2848. https://doi.org/10.3390/nu16172848 coffee, roast level, weight loss, body composition, fat mass, body fat percentage, lightly roasted coffee, regular roasted coffee, middle-aged adults, overweight, obesity, caffeine, antioxidants, metabolism, thermogenesis, gut health, microbiome, inflammation, blood sugar, insulin, blood pressure, cholesterol, heart health, weight management, healthy lifestyle, coffee consumption, scientific research, health benefits --- Support this podcast: https://podcasters.spotify.com/pod/show/ralph-turchiano/support

A groundbreaking study from UCLA Health reveals the potential of Manuka honey as a natural alternative for breast cancer treatment. Researchers discovered that Manuka honey significantly reduced tumor growth in mice with ER-positive breast cancer, while also showing promise in targeting cancer cells specifically. This exciting research offers hope for natural, less invasive approaches to breast cancer therapy. #manukahoney #breastcancer #cancer #research #study #clinicaltrials #UCLA #alternativemedicine #naturaltherapy #ERpositive #hormonepositive #breastcancersurvivor Márquez-Garbán DC, Yanes CD, Llarena G, Elashoff D, Hamilton N, Hardy M, Wadehra M, McCloskey SA, Pietras RJ. Manuka Honey Inhibits Human Breast Cancer Progression in Preclinical Models. Nutrients. 2024; 16(14):2369. https://doi.org/10.3390/nu16142369 manuka honey, breast cancer, cancer, research, study, clinical trials, UCLA, alternative medicine, natural therapy, ER-positive, hormone-positive, breast cancer survivor, preclinical study, scientific study, potential, treatment, natural remedies, health, healthcare, health tips, cancer awareness, prevention, medicine, science, medical research, medical studies, medical trials --- Support this podcast: https://podcasters.spotify.com/pod/show/ralph-turchiano/support

A groundbreaking study from UCLA Health reveals the potential of Manuka honey as a natural alternative for breast cancer treatment. Researchers discovered that Manuka honey significantly reduced tumor growth in mice with ER-positive breast cancer, while also showing promise in targeting cancer cells specifically. This exciting research offers hope for natural, less invasive approaches to breast cancer therapy. #manukahoney #breastcancer #cancer #research #study #clinicaltrials #UCLA #alternativemedicine #naturaltherapy #ERpositive #hormonepositive #breastcancersurvivor Márquez-Garbán DC, Yanes CD, Llarena G, Elashoff D, Hamilton N, Hardy M, Wadehra M, McCloskey SA, Pietras RJ. Manuka Honey Inhibits Human Breast Cancer Progression in Preclinical Models. Nutrients. 2024; 16(14):2369. https://doi.org/10.3390/nu16142369 manuka honey, breast cancer, cancer, research, study, clinical trials, UCLA, alternative medicine, natural therapy, ER-positive, hormone-positive, breast cancer survivor, preclinical study, scientific study, potential, treatment, natural remedies, health, healthcare, health tips, cancer awareness, prevention, medicine, science, medical research, medical studies, medical trials --- Support this podcast: https://podcasters.spotify.com/pod/show/ralph-turchiano/support

A new Australian study has highlighted the importance of magnesium in preventing accelerated aging. By reducing DNA damage and protecting against chronic diseases, magnesium plays a crucial role in preserving cellular health. The research suggests that maintaining adequate magnesium levels through dietary intake or supplementation could potentially slow down the aging process and reduce the risk of age-related health problems. #magnesium #health #antiaging #diseaseprevention #cancer #dnadamage #cellularhealth #alzheimers #parkinsons #cancer #diabetes #hearthealth #brainhealth Dhillon, V.S., Deo, P. & Fenech, M. Low magnesium in conjunction with high homocysteine increases DNA damage in healthy middle aged Australians. Eur J Nutr (2024). https://doi.org/10.1007/s00394-024-03449-0 magnesium, disease risk, DNA damage, chronic diseases, Alzheimer's, Parkinson's, cancer, diabetes, heart health, brain health, nutrition, supplements, cellular health, aging, anti-aging, longevity, health, wellness, lifestyle, healthy living, public health, medical research, scientific studies, health tips, medical advice, health information --- Support this podcast: https://podcasters.spotify.com/pod/show/ralph-turchiano/support

A new Australian study has highlighted the importance of magnesium in preventing accelerated aging. By reducing DNA damage and protecting against chronic diseases, magnesium plays a crucial role in preserving cellular health. The research suggests that maintaining adequate magnesium levels through dietary intake or supplementation could potentially slow down the aging process and reduce the risk of age-related health problems. #magnesium #health #antiaging #diseaseprevention #cancer #dnadamage #cellularhealth #alzheimers #parkinsons #cancer #diabetes #hearthealth #brainhealth Dhillon, V.S., Deo, P. & Fenech, M. Low magnesium in conjunction with high homocysteine increases DNA damage in healthy middle aged Australians. Eur J Nutr (2024). https://doi.org/10.1007/s00394-024-03449-0 magnesium, disease risk, DNA damage, chronic diseases, Alzheimer's, Parkinson's, cancer, diabetes, heart health, brain health, nutrition, supplements, cellular health, aging, anti-aging, longevity, health, wellness, lifestyle, healthy living, public health, medical research, scientific studies, health tips, medical advice, health information --- Support this podcast: https://podcasters.spotify.com/pod/show/ralph-turchiano/support

Aging is often accompanied by a decline in organ function, and the urinary tract is no exception. This video explores how cellular aging within the bladder contributes to increased vulnerability to urinary tract infections (UTIs). By understanding these age-related changes, we aim to identify potential anti-aging strategies that can improve bladder health and reduce the risk of UTIs. Our research offers insights into preserving urinary tract function as we age and highlights the potential of natural compounds like D-mannose in supporting overall well-being. #aging #mannose #urinarytractinfection #UTI #bladderhealth #autophagy #oxidativestress #Dmannose #cellularaging #antiaging #urothelialcells Joshi CS, Salazar AM, Wang C, Ligon MM, Chappidi RR, Fashemi BE, Felder PA, Mora A, Grimm SL, Coarfa C, Mysorekar IU. D-Mannose reduces cellular senescence and NLRP3/GasderminD/IL-1β-driven pyroptotic uroepithelial cell shedding in the murine bladder. Dev Cell. 2024 Jan 8;59(1):33-47.e5. doi: 10.1016/j.devcel.2023.11.017. Epub 2023 Dec 14. PMID: 38101412; PMCID: PMC10872954. Alchepharma,Ralph Turchiano,citation,research,study,aging,urinary tract infection,UTI,bladder health,autophagy,D-mannose,cellular aging,anti-aging,urothelial cells,bladder dysfunction,recurrent UTI,age-related UTI,mannose supplementation,bladder inflammation,urothelium,lysosomes,cellular debris,reactive oxygen species,ROS,cell death,exfoliation,bladder integrity,mouse model,UTI susceptibility,aging process,urinary tract health,D-mannose benefits --- Support this podcast: https://podcasters.spotify.com/pod/show/ralph-turchiano/support

Aging is often accompanied by a decline in organ function, and the urinary tract is no exception. This video explores how cellular aging within the bladder contributes to increased vulnerability to urinary tract infections (UTIs). By understanding these age-related changes, we aim to identify potential anti-aging strategies that can improve bladder health and reduce the risk of UTIs. Our research offers insights into preserving urinary tract function as we age and highlights the potential of natural compounds like D-mannose in supporting overall well-being. #aging #mannose #urinarytractinfection #UTI #bladderhealth #autophagy #oxidativestress #Dmannose #cellularaging #antiaging #urothelialcells Joshi CS, Salazar AM, Wang C, Ligon MM, Chappidi RR, Fashemi BE, Felder PA, Mora A, Grimm SL, Coarfa C, Mysorekar IU. D-Mannose reduces cellular senescence and NLRP3/GasderminD/IL-1β-driven pyroptotic uroepithelial cell shedding in the murine bladder. Dev Cell. 2024 Jan 8;59(1):33-47.e5. doi: 10.1016/j.devcel.2023.11.017. Epub 2023 Dec 14. PMID: 38101412; PMCID: PMC10872954. Alchepharma,Ralph Turchiano,citation,research,study,aging,urinary tract infection,UTI,bladder health,autophagy,D-mannose,cellular aging,anti-aging,urothelial cells,bladder dysfunction,recurrent UTI,age-related UTI,mannose supplementation,bladder inflammation,urothelium,lysosomes,cellular debris,reactive oxygen species,ROS,cell death,exfoliation,bladder integrity,mouse model,UTI susceptibility,aging process,urinary tract health,D-mannose benefits --- Support this podcast: https://podcasters.spotify.com/pod/show/ralph-turchiano/support

A new study shows a butyrate-based supplement can help people with fatty liver disease. Participants with fatty liver and metabolic syndrome took either the supplement or a placebo for 3 months. Those taking the supplement saw significant improvements in liver health markers like FLI and reduced levels of harmful fats in the blood. While more research is needed, these results are promising for finding new treatments for fatty liver disease. #fattyliver #NAFLD #butyrate #metaboliscsyndrome #liverhealth #liverdisease #guthealth #nutritionresearch #supplementation #dietandhealth #zinc #vitamind Fogacci F, Giovannini M, Di Micoli V, Grandi E, Borghi C, Cicero AFG. Effect of Supplementation of a Butyrate-Based Formula in Individuals with Liver Steatosis and Metabolic Syndrome: A Randomized Double-Blind Placebo-Controlled Clinical Trial. Nutrients. 2024; 16(15):2454. https://doi.org/10.3390/nu16152454 butyrate, fatty liver disease, NAFLD, metabolic syndrome, liver steatosis, gut microbiota, short-chain fatty acids, inflammation, insulin resistance, obesity, zinc, vitamin D, clinical trial, randomized controlled trial, placebo-controlled, supplementation, dietary intervention, liver enzymes, lipid profile, quality of life, patient outcomes, hepatic fibrosis --- Support this podcast: https://podcasters.spotify.com/pod/show/ralph-turchiano/support

A new study shows a butyrate-based supplement can help people with fatty liver disease. Participants with fatty liver and metabolic syndrome took either the supplement or a placebo for 3 months. Those taking the supplement saw significant improvements in liver health markers like FLI and reduced levels of harmful fats in the blood. While more research is needed, these results are promising for finding new treatments for fatty liver disease. #fattyliver #NAFLD #butyrate #metaboliscsyndrome #liverhealth #liverdisease #guthealth #nutritionresearch #supplementation #dietandhealth #zinc #vitamind Fogacci F, Giovannini M, Di Micoli V, Grandi E, Borghi C, Cicero AFG. Effect of Supplementation of a Butyrate-Based Formula in Individuals with Liver Steatosis and Metabolic Syndrome: A Randomized Double-Blind Placebo-Controlled Clinical Trial. Nutrients. 2024; 16(15):2454. https://doi.org/10.3390/nu16152454 butyrate, fatty liver disease, NAFLD, metabolic syndrome, liver steatosis, gut microbiota, short-chain fatty acids, inflammation, insulin resistance, obesity, zinc, vitamin D, clinical trial, randomized controlled trial, placebo-controlled, supplementation, dietary intervention, liver enzymes, lipid profile, quality of life, patient outcomes, hepatic fibrosis --- Support this podcast: https://podcasters.spotify.com/pod/show/ralph-turchiano/support

A groundbreaking study reveals that the over-the-counter supplement nicotinamide riboside can significantly improve walking ability in patients with peripheral artery disease (PAD). Participants in a six-month trial experienced a remarkable increase in walking distance, while those taking a placebo saw a decline. This affordable and accessible supplement offers new hope for millions living with this debilitating condition, potentially revolutionizing treatment options. #nicotinamide_riboside #peripheral_artery_disease #PAD #clinical_trial #vitamin_B3 McDermott, M.M., Martens, C.R., Domanchuk, K.J. et al. Nicotinamide riboside for peripheral artery disease: the NICE randomized clinical trial. Nat Commun 15, 5046 (2024). https://doi.org/10.1038/s41467-024-49092-5 nicotinamide riboside, peripheral artery disease, PAD, walking endurance, clinical trial, NAD, energy metabolism, muscle function, blood flow, DNA repair, randomized controlled trial, placebo, gastrocnemius, satellite cells, supplement, vitamin B3, over-the-counter, chronic leg disease, treatment options, exercise, rehabilitation, patient outcomes, quality of life, cost-effectiveness, healthcare, geriatrics, cardiology --- Support this podcast: https://podcasters.spotify.com/pod/show/ralph-turchiano/support

A groundbreaking study reveals that the over-the-counter supplement nicotinamide riboside can significantly improve walking ability in patients with peripheral artery disease (PAD). Participants in a six-month trial experienced a remarkable increase in walking distance, while those taking a placebo saw a decline. This affordable and accessible supplement offers new hope for millions living with this debilitating condition, potentially revolutionizing treatment options. #nicotinamide_riboside #peripheral_artery_disease #PAD #clinical_trial #vitamin_B3 McDermott, M.M., Martens, C.R., Domanchuk, K.J. et al. Nicotinamide riboside for peripheral artery disease: the NICE randomized clinical trial. Nat Commun 15, 5046 (2024). https://doi.org/10.1038/s41467-024-49092-5 nicotinamide riboside, peripheral artery disease, PAD, walking endurance, clinical trial, NAD, energy metabolism, muscle function, blood flow, DNA repair, randomized controlled trial, placebo, gastrocnemius, satellite cells, supplement, vitamin B3, over-the-counter, chronic leg disease, treatment options, exercise, rehabilitation, patient outcomes, quality of life, cost-effectiveness, healthcare, geriatrics, cardiology --- Support this podcast: https://podcasters.spotify.com/pod/show/ralph-turchiano/support