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4 episodes with type iii
3 episodes with type iii
2 episodes with type iii
2 episodes with type iii
2 episodes with type iii
3 episodes with type iii
3 episodes with type iii
3 episodes with type iii
2 episodes with type iii
Long time, Southern California, Volkswagen, mechanic and air cooled Aficionado Paul Ricketts sits down with Cameron to talk all things VW.Questions? Thoughts? Guest suggestions?Email us at aircooledlegendspodcast@gmail.comSubscribe to our newsletter:https://bio.site/aircooledlegendspodQuestions? Thoughts? Guest suggestions? Email us at aircooledlegendspodcast@gmail.comSubscribe to our newsletter:https://bio.site/aircooledlegendspod
Benjamin is the Founder of cap.In this episode, we dive into how Cap aims to unlock a new era of scalable stablecoin yield generation on Ethereum and MegaETH, by tapping into competitive markets and institutional players like Susquehanna, Franklin Templeton, and potentially DeFi powerhouses like Ethena and Maker.------
MCHD recently rolled out Ceftriaxone for long-bone open fracture care. The podcast crew welcomes our new assistant medical director, Dr. Mike DePasquale, to discuss some background evidence and danger spots within this protocol. REFERENCES: Lack, W. D., Karunakar, M. A., Angerame, M. R., Seymour, R. B., Sims, S., Kellam, J. F., & Bosse, M. J. (2015). Type III open tibia fractures: immediate antibiotic prophylaxis minimizes infection. Journal of orthopaedic trauma, 29(1), 1–6. Johnson, J. P., Oliphant, B. W., Dodd, J., Duckworth, R. L., Goodloe, J. M., Lyng, J. W., Sagraves, S. G., & Fischer, P. E. (2024). Prehospital Antibiotic Administration for Suspected Open Fractures: Joint COT/OTA/ACEP/NAEMSP/NAEMT Position Statement. Prehospital emergency care, 28(8), 1063–1067. Muniz, A. D., Gregorio, D. J., Studebaker, S. A., Peth, A. M., Camacho, C. G., Williams, B., Kupas, D. F., & Brown, L. H. (2024). Time Savings and Safety of EMS Administration of Antibiotics for Open Fractures. Prehospital emergency care, 28(8), 1046–1052.
We're thinking about changing our narrator's voice.There are three new voices on the shortlist. They're all similarly good in terms of comprehension, emphasis, error rate, etc. They just sound different—like people do. We think they all sound similarly agreeable. But, thousands of listening hours are at stake, so we thought it'd be worth giving listeners an opportunity to vote—just in case there's a strong collective preference. Listen and votePlease listen here:https://files.type3.audio/ea-forum-poll/ And vote here:https://forms.gle/m7Ffk3EGorUn4XU46 It'll take 1-10 minutes, depending on how much of the sample you decide to listen to.We'll collect votes until Monday December 16th. Thanks! ---Outline:(00:47) Listen and vote(01:11) Other feedback?The original text contained 1 footnote which was omitted from this narration. --- First published: December 10th, 2024 Source: https://forum.effectivealtruism.org/posts/Bhd5GMyyGbusB22Hp/ea-forum-audio-help-us-choose-the-new-voice --- Narrated by TYPE III AUDIO.
We are all assuming something about the nature of reality. Our core assumptions exist because there isn't definitive proof for any belief system. In this thought-provoking episode, Catherine and her guest, David Richardson, take a deep dive into the core assumptions that shape our beliefs about reality. In his first book Transparent: How to See Through the Powerful Assumptions That Control You, Dave defines the three primary types of assumers: Type I, Type II, and Type III, each with distinct perspectives on the nature of reality. Type I Assumers believe in a materialistic world where only physical matter and energy are considered real and important. This perspective is the foundation for understanding the world through a purely physical lens. Type II Assumers view reality as primarily non-physical, emphasizing beliefs that focus on spiritual or idealistic objectives. This perspective leads to beliefs in spiritual evolution or sociopolitical perfection as driving forces in the universe. Type III Assumers recognize a dual reality where both physical and non-physical aspects coexist, all created by a higher power. This perspective highlights the importance of acknowledging the Creator and creation in shaping one's view of reality. The impact of these core assumptions are vast and explain virtually everything that is going on in our world today, like how extreme progressives are siding with radical Islamists on college campuses. Have you been wondering why that is? If you look at what Islam teaches, it is the opposite of what Progressivism preaches. They are diametrically opposed. Dave explains how such divergent belief systems are finding a kinship on college campuses across the country. Spoiler alert: It has something to do with their underlying assumptions. Dave also shares his critical assumptions test, an invaluable evangelistic tool that helps individuals evaluate a person's core assumptions and their alignment with reality. This test consists of eight questions that prompt someone to reflect on their beliefs about the nature of reality, the origin of knowledge, and the purpose of human existence. By engaging with this test, you can quickly assess what a person believes and see how their core assumptions affirm or deny reality. Guest bio: David Richardson, author of Transparent: How to See Through the Powerful Assumptions That Control You, is the founder of the Assumptions Institute and its Chief Executive Officer. Prior to founding the Assumptions Institute, Richardson served for 30 years on the staff of Cru, formerly known as Campus Crusade for Christ, devoting most of his ministry to university professors. He holds a B.A. degree in Interdisciplinary Studies from the University of Portland, and an M.A. degree in Theological Studies from the International School of Theology. Richardson also holds an MTh. degree in Applied Theology from the University of Oxford. EPISODE RESOURCES & LINKS: UC Berkeley's campus is in turmoil. It's unlike anything in recent memory – Politico (4/21/24) BLM spent at least $12M on luxury properties in LA, Toronto – New York Post (5/17/22) Black Lives Matter Secretly Bought a $6 Million House – New York Mag: Intelligencer ((4/4/22) Jennifer Fulwiler Testimony - From Atheist to A Daughter of God – Godstrong Faith SCRIPTURE PASSAGES REFERENCED: Gen. 11 – The Tower of Babel Rom. 7:18 Discover more Christian podcasts at lifeaudio.com and inquire about advertising opportunities at lifeaudio.com/contact-us.
In dieser Folge sprechen wir über das Thema Hypermobilität? Was ist das eigentlich, wie finde ich heraus, ob ich vielleicht hypermobil bin und was kann ich dagegen tun? Was ist das Ehlers-Danlos Syndrom und was hat das ganze mit ADHS und Autismus zu tun? Außerdem gehen wir auf ein paar interessante Belgleitsymptome wie chronische Schmerzen, Kopfschmerzen und die gehäufte Verletzungsgefahr ein. Schaue auf Instagram bei @paula.klisiewicz vorbei! Hier lernst du noch mehr zum Thema Hypermobilität. Quellen: Tinkle et al.: Hypermobile Ehlers–Danlos Syndrome (a.k.a. Ehlers–Danlos syndrome Type III and Ehlers–Danlos syndrome hypermobility type): Clinical description and natural history https://doi.org/10.1002/ajmg.c.31538 Carroll, Matthew: Hypermobility spectrum disorders: A review https://doi.org/10.2478/rir-2023-0010 Wolf et al.: Impact of joint laxity and hypermobility on the musculoskeletal system https://journals.lww.com/jaaos/fulltext/2011/08000/impact_of_joint_laxity_and_hypermobility_on_the.2.aspx Baeza-Velasco et al.: Autism, Joint Hypermobility-Related Disorders and Pain https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2018.00656/full
“Blood sugar is like comparing water to Kool-Aid – while water flows through our body, Kool-Aid can't flow as well because it's stickier. When we have too much sugar in our bloodstream, our body has a harder time carrying out the processes it needs to.” - Dr. Georgia Nab About 1 in 5 people in the United States have diabetes but don't know it, according to the CDC. While people generally know sugar isn't good for the body, most people don't know why our consumption of it needs to be managed – not eliminated. In today's show, Dr. Michelle Robin invites Dr. Georgia Nab – a Functional Medicine doctor at Your Wellness Connection – to help people understand what's really happening in the body once we consume sugar and why it's then converted to blood sugar. If you have ever wondered what glycemic and glucose mean – or the difference between metabolic syndrome (prediabetes), Type I, Type I.5, Type II, and Type III – this week's episode will give you a clearer understanding of each one in very simple terms. Dr. Nab even dives into how our blood sugar numbers have a tremendous impact on our hormonal levels and anxiety issues in today's world. She encourages listeners that small changes can make a big difference. At the end of the episode, Dr. Nab will also share why sleep and movement matter in managing your blood sugar – ending with some tips that can help you get on a better path toward wellness. About Today's Guest: Dr. Georgia Nab entered the chiropractic industry in 1992 by owning a chiropractic clinic in Wichita, Kansas. From 2012 through 2017, she joined a manufacturing facility in Wisconsin to provide chiropractic care, nutritional counseling, and educational training to the employees at the company's corporate headquarters. While there, she authored her book called 1 Degree of Change, in addition to numerous other publications. In 2015, she graduated with her Master's degree in Human Nutrition and Functional Medicine degree. She is currently an adjunct professor at the University of Western States for their Master's program. Dr. Nab is a Certified Nutrition Specialist from the Board for Nutrition Specialist and works with Affiliated Monitors, an independent monitoring company for professionals. Mentioned in the Episode: Your Wellness Connection 1 Degree of Change book by Dr. Georgia Nab – contact Dr. Nab for a free PDF version
Air Cooled Legends travels to the OCTO Show (Orange County Transporter Organization) Winter Meet 2024. This event is exclusively for 1967 and earlier Volkswagen buses, taking place at Long Beach Veteran's Memorial Stadium in Long Beach, CA, where enthusiasts gather to swap parts and showcase their vehicles. We go inside and talk to organizers, vendors, VW owners and even other podcast hosts!Find out more about OCTO here: http://octo.org/Questions? Thoughts? Guest suggestions? Email us at aircooledlegendspodcast@gmail.comSubscribe to our newsletter:https://bio.site/aircooledlegendspod
Step into the extraordinary with The Box of Oddities podcast! This captivating episode delves into four intriguing and bizarre topics that will leave you spellbound. First, we unravel the enigmatic USS Stein Incident, where a naval vessel encountered a mysterious force lurking in the ocean's depths. Join us as we explore the eerie details and uncover the truth behind this strange maritime anomaly. Next, we journey to the Nordic regions to uncover the peculiar tradition of leaving babies outside in the winter cold. Discover the cultural significance and surprising benefits of this age-old practice that continues to baffle and intrigue. Then, prepare to expand your mind as we discuss the Kardashev Scale of civilization and contemplate mankind's potential future. From Type I to Type III civilizations and beyond, we ponder the technological advancements and cosmic possibilities that await humanity. And finally, we uncover the chilling tale of Asa Snow, a man who shocked the world by digging up his own deceased family. What drove him to such a macabre act? Join us as we unravel the mystery and explore the dark depths of human psychology. Climb into The Box of Oddities podcast for a mind-bending journey through the weird and wonderful world of the unexplained. Don't miss out on this eclectic mix of curiosities and oddities that will leave you both amazed and bewildered. This Box contains the following ingredients: USS Stein Incident, Nordic baby tradition, Kardashev Scale, future of mankind, Asa Snow, strange, bizarre, mysterious, unexplained, curiosity, oddity, macabre, folklore, paranormal, phenomenon, maritime, culture, civilization, psychology. If you would like to advertise on The Box of Oddities, contact sales@advertisecast.com http://www.airwavemedia.com Learn more about your ad choices. Visit megaphone.fm/adchoices
Chris Holman welcomes back Rodney Cole, President DTE Foundation and DTE Corporate Citizenship at DTE Energy, Detroit, MI. In their conversation, Chris wanted to learn several things from Rodney: We're still in the beginning of 2024, so tell me about the DTE Foundation's impact in 2023? What can we look forward to from the DTE Foundation in 2024? What was the driving factor for launching this program? What are the outcomes you're looking for from the Community Transformation grant program? What else can we expect from the DTE Foundation this year? DTE is sharing further information as well in a release: DTE Energy Foundation invites community transformation-focused nonprofits to apply for $150K in grant support Detroit, Mich. (March 1, 2024) – The DTE Energy Foundation today invited Michigan nonprofits that serve local communities to submit Letters of Intent for a chance to be selected for a grant that will support community transformation efforts. The DTE Foundation will provide up to $150,000 to be shared across two or more Michigan nonprofits focused on local, community transformation and revitalization. Letters of Intent will be accepted now through 5 p.m. on Wednesday, May 1. Nonprofit organizations interested in applying can do so at the link here. The winning nonprofits will be notified by Friday, Oct. 4. “Community Transformation is a key focus of the DTE Foundation, and we understand each city in Michigan has needs specific to residents and their location,” said Rodney Cole, president of the DTE Foundation. “That's why it's important for us to hear from the nonprofit applicants, ensuring we support their unique mission and community needs. “ The DTE Foundation transforms lives by helping area communities renew, refresh, or create community space, restore safety, beautify blocks, and increase community health and well-being. It focuses on community spaces, safety and security, and community development. Grants will be considered when meeting the following criteria: · Applicants must be legally established 501(c)(3) public charities by the Internal Revenue Service and have the capacity to directly receive and manage the grant to be eligible. · Fiduciary, fiscal sponsor payment arrangements and Type III supporting organizations are not eligible. · The organization must be located in and directly benefit a project in Michigan. · The DTE Foundation must be the majority contributor to the overall project. · Submitted projects cannot be energy-related in any way. · The organization must provide a long-term sustainability plan for any future needs of the project. · The grantee must provide an annual report detailing the community impact of the grant. · The organization must be willing to fulfill press release and grant presentation requests. About the DTE Energy Foundation The DTE Foundation is the philanthropic arm of DTE Energy, continuing the legacy of community support and involvement of its electric and natural gas utilities, which serve 2.3 million electric customers in Southeast Michigan and 1.3 million natural gas customers in Michigan. In 2023, the DTE Energy Foundation provided more than $17 million in grant support to nearly 300 nonprofits where the company has a business presence with a focus on driving positive, meaningful change in key areas like jobs, equity, human needs and the environment. As one of Michigan's leading corporate citizens, DTE aspires not only to be the best in the world, but the best for the world, serving as a force for growth and prosperity in the communities across Michigan. Visit DTEFoundation.com to learn more. ### » Visit MBN website: www.michiganbusinessnetwork.com/ » Subscribe to MBN's YouTube: www.youtube.com/channel/UCqNX… » Like MBN: www.facebook.com/mibiznetwork » Follow MBN: twitter.com/MIBizNetwork/ » MBN Instagram: www.instagram.com/mibiznetwork/
Kengal Mehar Shrestha, the talented singer who captured hearts on Nepal Idol Season 1, and her band Type III delve into the dynamic world of the music industry. From their creative process to memorable stories from their time together, they offer a unique glimpse into the life of musicians.
Proper treatment of Type III AC Joint Separations has been a topic of ongoing debate. In OJSM's August edition, Drs. Mark Tauber, Phillipp Moroder and their team from the German Shoulder Center in Munich, Germany, published, “Prospective Multicenter Randomized Controlled Trial of Surgical Versus Nonsurgical Treatment of Acute Rockwood Type 3 Acromioclavicular Injury,” a high-level study that showed no difference in outcomes between surgical and nonsurgical management of this injury. We are joined by two of the finest surgeons in California's Central Valley, Shoulder/Elbow Specialist Dr. Julia Lee, MD from Sierra Pacific Orthopedics and Traumatologist Dr. JT Christensen, MD from Kaiser Permanente to discuss this study and share their insights and practices.
Today we talk to Alex, the owner/founder at ISP West in Carson, California. they're a full service shop that works on any kind of Volkswagen, but specialize in Type III. You can bring your car in and they'll do a tune up but what they really like to do is full blown, nut and bolt restoration.Find Alex at https://vwispwest.com/Questions? Thoughts? Guest suggestions? Email us at aircooledlegendspodcast@gmail.comSubscribe to our newsletter:https://bio.site/aircooledlegendspod
Welcome to EO Radio Show - Your Nonprofit Legal Resource. I'm Cynthia Rowland, and today's episode discusses highly technical Supporting Organization rules for public charity qualifications for charitable organizations. Last year, episodes 23 and 24 of EO Radio Show covered the complex rules that describe supporting organizations, which are a special classification of public charity for US federal income tax purposes. All supporting organizations must pass complicated tests intended to ensure that the supported organization is not effectively a private foundation. These rules were initially enacted in 2006, and proposed regulations were published in 2016. On October 13, 2023, the US Treasury released new final regulations that make minor changes to the Type I test and more significant clarifications to the Type III requirements. This episode outlines the changes made in these final regulations applicable to certain parts of the qualification criteria for supporting organizations. Resources: Federal Register: Requirements for Type I and Type III Supporting Organizations EO Radio Show EP 23: Nonprofit Basics: Supporting Organizations - Part 1 EO Radio Show EP 24: Nonprofit Basics: Supporting Organizations Part 2 - Orientation for Understanding Type III Supporting Organizations If you have suggestions for topics you would like us to discuss, please email us at eoradioshow@fbm.com. Additional episodes can be found at EORadioShowByFarella.com. DISCLAIMER: This podcast is for general informational purposes only. It is not intended to be, nor should it be interpreted as, legal advice or opinion.
For most, working out is something we don't always love in the moment, but we do appreciate it after the fact. There's a term for that — "Type II fun" — and we're talking about that, as well as Type I and Type III fun, in today's episode and HOW they all apply to fitness. Subscribe to the Podcast on YouTube! Ready to STAY CONSISTENT? Join the next free Tough Love Mom Consistency Challenge! One habit, one month. Take on the Free Consistency Challenge! Frustrated and falling off the wagon every time you try to lose weight? Ready to simplify your journey so you can finally stay consistent for good? Join Starting Point School! Get tough love texts from me each week to keep you motivated and encouraged! Text "tough love" to 205-809-7300! Are you ready to make this journey SIMPLE so you can stop feeling overwhelmed and START getting disciplined, consistent, and confident? Book your Starting Point Session and let's get you back on track! COMMUNITY: Join The Tough Love Mom Squad on FB! Connect: support@thetoughlovemom.com Learn more: thetoughlovemom.com Instagram: @mrslizhenderson
How much does collagen count toward your protein needs? It's an excellent question. There are a couple things to keep in mind with protein. It's like a prescription med in that if you don't have enough of it, you don't get the benefit. You'd never take an Rx med just half now and half later if it is supposed to be taken 3x a day in the full dose. Likewise with protein. If you don't get enough for the muscle protein synthesis, that is, the ability to boost an anabolic reaction in the muscle, you may support satiety and blood sugar stabilization but not preserve your lean muscle mass. Second, all protein is not created equal. Animal protein per calorie has a far higher level of essential amino acids than does plant. All animal protein is not even the same. And though collagen protein is animal, it's a lower level than plant. Not all collagen protein is a complete essential amino acid source. But even so, it can be deceptive if you're thinking, adding that scoop to your coffee covers your protein needs for morning. So, let's unpack this in today's episode and a lesser known fact that a Protein Digestibility-corrected Amino Acid Score could also have an effect on your ability to use what you consume. Are you in? The Stronger Program is open for enrollment! Start Now: https://www.flippingfifty.com/getstronger More than 20 strains of collagen have been identified. These 5 are most common in those on the shelves you may be staring at literally or virtually. Type I – present in bones and muscles Type II – cartilage and bones Type III – blood vessels (and other “hollow” organs) Type VI – skin Type V – prime protein in skeletal muscle and corneal stroma Type I represents 90% of total collagen content of the body. How Much Collagen for Best Results May Depend on This PDCAAS (Protein Digestibility-corrected Amino Acid Score), collagen protein lacks one indispensable amino acid (tryptophan) and is therefore categorized as an incomplete protein source. Collagen protein displays a low indispensable amino acid profile, yet as a functional food, collagen is a source of physiologically active peptides and conditionally indispensable amino acids that have the potential to optimize health and address physiological needs posed by aging and exercise. “36% of collagen peptides can be used as protein substitution in the daily diet while ensuring indispensable amino acid requirements are met. This study suggests that the effective amounts of functional collagen peptides (2.5 to 15 g per day) observed in the literature are below the maximum level of collagen that may be incorporated in the standard American diet.” Numerous Studies on Collagen Have Shown: · improvement in skin elasticity · recovery of lost cartilage tissue · reduced activity-related joint pain · strengthened tendons and ligaments · increased lean body mass in elderly men and premenopausal women · increased bone mineral density in postmenopausal women “These studies have investigated supplementation with doses of 2.5 to 15 g of bioactive collagen peptides over periods of three to 18 months. The benefits are reportedly due to bioactive collagen peptides to upregulate the synthesis of extracellular matrix proteins in various tissues via a stimulatory cell effect while providing the specific amino acid building blocks for body collagens.” Ideally, the amino acid scores (AAS) of a protein or protein mixture should not exceed 1.0, i.e., fulfill 100% of the indispensable amino acid requirements while minimizing excess. This is due to the fact that the body's metabolic needs include both indispensable and dispensable amino acids. As a consequence, if one or more of the indispensable amino acids are present in excess of requirements, the diet becomes limited in dispensable amino acids, thus unbalanced, even though the PDCAAS remains equal to 1.0. So, How Much Collagen Based on SAD A level as high as 36% of collagen peptides may be used as protein substitution while maintaining the indispensable amino acid balance and the high protein quality score of the standard American diet (PDCAAS equals to 1.0). The PDCAAS calculation of the daily protein mixture contained 36% collagen peptides and 64% mixed proteins from the standard American diet. More Collagen to Consider: Peptides vs Powders Considering the two, peptides are short strings of amino acids – two or three joined together – making them even easier to digest and absorb. For regeneration of connective tissue in joints, ligaments, bone and skin, or gut collagen peptides are what you want. Without getting too much into “other” subjects here there are also creatine peptides that support muscle strength, recovery, short bursts of power and supports ATP (energy central). References: https://www.mdpi.com/2306-5354/9/5/193 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566836/ Resources: STRONGER 12-week program: https://www.flippingfifty.com/getstronger Other Episodes You Might Like: What to know about CREATINE Supplementation Over 50: https://www.flippingfifty.com/?s=creatine Collagen or Protein Shakes for Lean Muscles After 50?: https://www.flippingfifty.com/?s=collagen Protein Supplements for Muscle Building: What, When & Why to Exercise for Women 40+: https://www.flippingfifty.com/?s=protein
Do You Have Sagging Facial Skin? Here's why COLLAGEN PEPTIDES are so great at maintaining healthy, glowing skin!** Collagen is a naturally occurring protein that plays a crucial role in keeping your skin firm and plump, which is why it makes up to three-quarters of your skin's dry weight. Although your skin naturally produces its own supply of collagen, this production noticeably slows down as you age. Fortunately, you can boost your body's collagen levels by regularly consuming high-quality collagen peptides, thereby supporting the growth of healthy, glowing skin. To help you maintain optimal collagen levels and support healthy skin, Collagen peptides** Making up 25-35% of your body's total protein content, collagen is a structural protein that is the most abundant protein in the human body. Often found in your skin, bones, muscles, tendons, ligaments, cartilage, teeth and blood vessels, this structural protein serves as the main component of your bones and connective tissues. Your body naturally produces collagen but as you age, your body's collagen production declines considerably. Collagen peptides are a bioavailable form of collagen produced through a process called hydrolysis. This process breaks down collagen into smaller, more digestible pieces that your body can more easily use as building blocks to repair and rejuvenate your aging tissues. Hydrolysis makes collagen more easily digestible without diminishing its nutritional content. The most important and abundant types of collagen are Type I and Type III collagen. Considered the strongest type of collagen, Type I collagen consists of fibers that make up your skin, bones, muscles, tendons, ligaments and other body parts. It is also responsible for supporting optimal skin health and elasticity. Furthermore, Type I collagen contains 19 amino acids, including alanine, glycine, proline and hydroxyproline. Meanwhile, Type III collagen is a fibrillary collagen that is primarily found in your skin, lungs, intestines, bowels, vascular system and other connective tissues. #collagen #skincare #beauty #antiaging #collagendrink #skin #vitaminc #glutathione #kolagen #glowingskin #pemutihkulit #whitening #skincareroutine #pemutihbadan #healthyskin #serum #health #collagenpowder #vitamin #acne #gluta #vgspremium #pemutihwajah #healthylifestyle #in #glowing #glutax #pemutih #fitness #facial --- Send in a voice message: https://podcasters.spotify.com/pod/show/bhsales/message
Running a Non-Profit Charity The Piper Trust w/ Steve Zabilski - BRT S04 EP27 (190) 7-9-2023 What We Learned This Week: Virginia G. Piper Trust - Virginia & husband Bob Galvin (founder Motorola) created in 2000 Charity Grants application process Investment to grow Trust Fund of $400m Phx Dream Ctr staff are largely made up of former victims giving back St Vincent helps the Homeless Population In Phx A for Arizona celebrates educators Guest: Stephen J. Zabilski, President & CEO https://pipertrust.org/about-us/officers-and-staff/ As President and CEO, Steve Zabilski leads Virginia G. Piper Charitable Trust's mission to enrich health, well-being, and opportunity for the people of Maricopa County. Steve joins Piper Trust as its fourth CEO after providing more than 17 years of dedicated service as a Trustee and member of the organization's Investment and Audit Committees. For the past 25 years, Steve served as CEO of the Society of St. Vincent de Paul—Phoenix Diocesan Council. His decades of private sector experience, coupled with his talent to lead with compassion and humility, continue to make an indelible mark on this community. Steve's ability to bring people together and catalyze the strengths of thousands of Vincentians, volunteers, employees, and donors significantly advanced the mission and services of St. Vincent de Paul. During Steve's tenure, St. Vincent de Paul's health clinic space doubled, enabling treatment for many more people; dining rooms served meals 365 days a year; three urban farms were installed that provide scores of food-insecure people with fresh produce daily; and, a transitional shelter and resource center was established. Further, the St. Vincent de Paul community created an inspiring environment where people find purpose and joy through myriad volunteer opportunities. St. Vincent de Paul received a President George H.W. Bush Points of Light Award in 2001 for having one of the most family-friendly volunteer programs in the country. Prior positions include senior vice president with Transamerica Insurance Group and audit manager for the accounting firm KPMG (formerly Peat Marwick). Steve is a member of the board of trustees of St. Vincent de Paul and Great Hearts Arizona. He is a past member of the American Institute of Certified Public Accountants and the FBI Citizen's Academy and has served as president of the board of trustees of Ville de Marie Academy among several school and parish advisory councils. Steve was honored by Grand Canyon University's Colangelo College of Business with a Colangelo Servant Leadership Award in January 2023. History of Piper Trust Philanthropy and Vision The wife of Motorola founder Paul V. Galvin, Virginia Galvin Piper sought to follow her husband's philanthropic example by establishing a charitable legacy of her own. “For me,” she wrote, “managing the stewardship of charitable giving is a moment-to-moment dignified responsibility of a truly high calling in human affairs and human relations.” · For the last three decades of her life Mrs. Piper lived in Paradise Valley, Arizona, where she moved from Chicago with her second husband, Kenneth M. Piper. During that time she worked quietly and steadily at strengthening Phoenix-area nonprofits. · Mrs. Piper established the Trust in 1995 and appointed four lifetime trustees to oversee the work of the foundation. Shortly after Mrs. Piper's death in 1999 the trustees began the formal work of the Trust. · Upon settlement of Mrs. Piper's estate in 2000 the Trust received approximately $600 million. This sum made the Trust one of the nation's 100 largest foundations. Devotedly, Virginia: The Life of Virginia Galvin Piper compiles over 100 interviews with people who knew Mrs. Piper. Grantmaking · In December 2000 a select group of organizations, which Mrs. Piper had supported over the years, received from the trustees eight Cornerstone Grants. These grants totaled $41 million. · February 2002 saw trustees award the first round of competitive grants, which totaled $11.5 million, to 68 organizations. · Each year nonprofits serving the people of Maricopa County receive an average of $25 million from Piper Trust. Since the Trust began awarding grants in 2000, it has invested more than $684 million in local nonprofits and programs as of as of July 2022. Notes: Seg. 1 History of the Trust Steve Zabilski bio and past work at St. Vincent Was on the board at Piper Trust, now on the board at St. Vincent Investment portfolio of $400 mil, fiduciary responsibility to grow funds Per non-profit rules, IRS Code 5013C, must give away 5% of the fund per year, or $20 mil + other expenses of Trust Prudent investments of stocks, bonds, private equity, venture capital, hedge funds, some alternative investments Some funds, investment is illiquid, cannot get funds easily Work with 1 financial group who oversees the fund Seg. 2 In 2020, Covid hit organizations hard, and difficult to get donations Higher education grants, ex. – Creighton University, built med school in Phoenix Only donate to business in Maricopa County Health and medical research – ASU, TGen Senior needs and older adults – food assistance, St. Vincent homeless shelter Boys & Girls Club, Boys Hope & Girls Hope, High School orgs Board Meeting every month, lasts 3 hours and is very involved Financial statement review, investment portfolio update Program Updates – who to fund, how much, is it a multi-year grant Chronicle of Philanthropy news Audit Committee- internal controls, Mgmt letters Finance Committee Breakfast meeting monthly Seg. 3 Special Day in Sep. 2021 – donated $123 mil, average donation in a year, 5% or $20 mil From April 2020 to June 2021, fund had grown $123 mil, made decision to give away 100% of funds, Sep. 2021 met with 71 charities, had long term donations and make the $123m donation, unrestricted funds, charities could use the $ for whatever they needed Restricted Funds – when a donation is for a specific purpose or project, building a center, etc. Grant Cycle – App process, FAQ on website https://pipertrust.org/grant-process/faq/ Q: What does Piper Trust fund? A: Piper Trust makes grants to projects that intervene in the following areas: · Arts and Culture · Children · Education · Healthcare and Medical Research · Older Adults · Religious Organizations Piper Trust's particular interest lies with projects that benefit young children, adolescents and older adults in Maricopa County. The Trust makes grants to faith-based organizations that serve these target populations in a manner consistent with program guidelines. Q: What types of organizations does Piper Trust fund? A: Piper Trust makes grants to actively operating Section 501(c)(3) organizations in Maricopa County. These organizations must have been in operation for at least three years from the effective date of their IRS ruling. Special rules apply to private foundations and 509(a)(3)(Type III) organizations. Letter of Inquiry, then Submit application for review: Q's and decision process, must meet guidelines, longer process for new request, due diligence, how org runs, check paperwork, financials, tax returns, confirm status of 5013C, internal reviews, need budgets and plan for money take 2 months Piper Trust has ongoing relationships with charities, where grant process can be quicker, usually donates to same org every other year Multiyear Grant – could be ongoing donation Seg. 4 – Charity Show Flashback BRT Holiday Show – We Give Thanks & Give Back - BRT S02 EP 46 (93) 11-14-21 Guest: Steve Zabilski, Executive Director of St Vincent DePaulhttps://www.stvincentdepaul.net/about/our-board Homeless Population in Phx Struggling and How to Help Help to Feed, Clothe, House, Heal those who need it most Things We Learned This Week: · St Vincent DePaul helps feed and clothe the homeless population · St Vincent also provides financial assistance to families in need, and has clinics on site · MAM is helping the average military family get by · Hope & A Future helps foster kids find a brighter future · A for Arizona is working with teachers who are improving education Steve Zabilski has served as the Society of St. Vincent de Paul's Executive Director since 1997. Prior positions include senior vice president with Transamerica Insurance Group and audit manager for the accounting firm KPMG LLC. Steve Zabilski embodies the philosophy of serving those in need. And appropriately, he is well-situated to live out those precepts of charity as CEO of the Society of St. Vincent de Paul (SVDP) Phoenix, where he oversees the day-to-day operation of the organization's 250 employees and thousands of volunteers throughout Arizona. The Society of St. Vincent de Paul is dedicated to feeding, clothing, housing and healing individuals and families in our community who have nowhere else to turn for help. As important, SVdP provides meaningful opportunities for volunteers to serve their neighbors in need with love and compassion. Phoenix Dream Center – from 7/18/2021, Seg. 2 Guest: Michelle Tipton, Public Relations/ Volunteer Coordinator, Phoenix Dream Center https://phoenixdreamcenter.org/ https://phoenixdreamcenter.org/story/ https://phoenixdreamcenter.org/kfnx/ - to help & donate, tax deductible The problem of Human Traffic is a bigger issue than most people realize. Emily Anne Gullickson, CEO of A for Arizona - www.aforarizona.org As employers, innovators, and investors in the future, we remain committed to ensuring business leaders stay engaged as education champions. We aim to continue to educate and build wider support from the business community on the ambitious, aggressive, and comprehensive education reform possibilities designed from the needs and best practices of Arizona's exceptional educators Full Show: HERE For More Info and Community Shows or to Help: https://brt-show.libsyn.com/category/Community ‘Best Of' Topic: https://brt-show.libsyn.com/category/Best+of+BRT Thanks for Listening. Please Subscribe to the BRT Podcast. Business Roundtable with Matt Battaglia The show where Entrepreneurs, High Level Executives, Business Owners, and Investors come to share insight and ideas about the future of business. BRT 2.0 looks at the new trends in business, and how classic industries are evolving. Common Topics Discussed: Business, Entrepreneurship, Investing, Stocks, Cannabis, Tech, Blockchain / Crypto, Real Estate, Legal, Sales, Charity, and more… BRT Podcast Home Page: https://brt-show.libsyn.com/ ‘Best Of' BRT Podcast: Click Here BRT Podcast on Google: Click Here BRT Podcast on Spotify: Click Here More Info: https://www.economicknight.com/podcast-brt-home/ KFNX Info: https://1100kfnx.com/weekend-featured-shows/ Disclaimer: The views and opinions expressed in this program are those of the Hosts, Guests and Speakers, and do not necessarily reflect the views or positions of any entities they represent (or affiliates, members, managers, employees or partners), or any Station, Podcast Platform, Website or Social Media that this show may air on. All information provided is for educational and entertainment purposes. Nothing said on this program should be considered advice or recommendations in: business, legal, real estate, crypto, tax accounting, investment, etc. Always seek the advice of a professional in all business ventures, including but not limited to: investments, tax, loans, legal, accounting, real estate, crypto, contracts, sales, marketing, other business arrangements, etc.
In this episode, Alexander and Jason will embark on an exciting journey to explore the diverse types of civilizations that may exist beyond our planet. The universe is a vast expanse, teeming with countless stars and galaxies. With such an immense cosmic landscape, it's difficult to imagine that Earth is the only planet hosting life. Scientists and thinkers have long pondered the possibility of extraterrestrial civilizations, sparking our curiosity about the different forms they could take. In our quest to understand these potential civilizations, let's delve into three broad categories that scientists and theorists often discuss: Type I, Type II, and Type III civilizations, as originally proposed by the physicist Kardashev. Let's break it down: Type I civilization is one that harnesses and utilizes all the energy resources available on its home planet. This civilization would have advanced technology, clean and efficient energy sources, and global unity in managing their planet's resources. As a comparison, Earth is not yet a Type I civilization but is gradually making strides toward achieving this status. Type II civilization takes the concept of harnessing energy to a cosmic scale. They would be capable of utilizing and controlling the energy output of an entire star, like our Sun. This level of advancement would require the ability to construct megastructures, such as a Dyson sphere, to capture a significant portion of a star's energy. With this incredible power at their disposal, Type II civilizations could explore their galaxy and potentially make contact with other advanced civilizations. Type III civilization would have complete mastery over the energy of an entire galaxy. They would possess technology far beyond our comprehension, enabling them to harness the energy of billions of stars and traverse vast cosmic distances effortlessly. Their knowledge and capabilities would be virtually limitless, and they may even possess the ability to manipulate space-time itself. Type IV would almost be able to harness the energy content of the entire universe and with that, they could traverse the accelerating expansion of space. Type V is suggested to be advanced enough to escape their universe of origin and explore the multiverse. Such a civilization would have mastered the technology to a point where they could simulate or build a custom universe. While the Kardashev scale provides a framework for understanding different types of civilizations, it's important to note that it is based on our current understanding of science and technology. Future discoveries could introduce new categories and dimensions to this classification system. Additionally, there may be other forms of civilizations that exist beyond the Kardashev scale, with unique characteristics and abilities that we can't even fathom at present. Speculating about such civilizations allows our imagination to run wild and sparks wonder and excitement about the possibilities that lie beyond our own world. In conclusion, as we ponder the potential existence of extraterrestrial civilizations, exploring the different types of civilizations provides us with a framework for understanding the range of possibilities. From Type I civilizations harnessing their planet's resources to Type II civilizations manipulating the energy output of stars, and the unfathomable capabilities of Type III civilizations, our exploration of these concepts ignites our imagination and deepens our appreciation for the vastness and diversity of the universe. Let us join Alexander and Jason as they explore different civilizations. www.higherdensityliving.com Click here to Support Higher Density Living - Invest in Expanding Human Consciousness
Today I'm honored to have Sean Liscom, author of The Ranch book series available on Amazon. I've been reading the entire series and thought I might as well ask if the author would be on the show, and surprisingly, he said yes! So today, we have a great chat about the origins of The Ranch series, his writing method, life living off the grid, and the art of living a life of being prepared. Sean has a background in wild land firefighting, and we learn all of the lessons that come from a life of unpredictability. IG @jasonwsterling Sean's Bio: I was born in October of 1970 in California but have lived in northern Nevada since 1977. At an early age, I was bitten by the Fireman bug. In the spring of 1988 I joined the local volunteer fire department. I served in several different capacities from Firefighter I, EMT-B, Engine Operator, Safety Officer, Training Officer, Engine Captain and Type III Incident Commander. I retired on 01-01-11. During the summer of 1989, I found myself joining up with a government contracted engine strike team. I also served with them in different positions that mirrored my volunteer service with the exception of becoming a Strike Team Leader. With 5 Type III engines, two water tenders and two service vehicles under my control, I had to quickly learn how to deal with the "human" element. I must have done okay because they kept asking me to come back to work for them. That lasted until the season ended in 1999. In September of 2016, I sat down with my laptop and started writing. The story that unfolded in my head and on the computer screen is what I submitted to Amazon a year later. Of course, there were re-writes and the inevitable writers block, but I managed to work my way through that with the help and support of my beautiful wife, Denise. Even when she was struggling with the hellish side-effects of chemotherapy, she stood strong and let me bounce ideas off of her. 0:00 - Start 1:30 - Intro to book 3:00 - Craziest thing he saw 11:00 -“I write for a living” 16:30 - How much of the story is autobiographical? 24:41 - How do you outline a story? 33:30 - What inspires your characters? 36:00 - Political themes 44:00 - A Simple cut will kill you 52:00 - What are some realizations in life 54:30 -Composting toilets 1:00:00 - Inspiration for the world building 1:07:30 - The entrepreneurial journey 1:11:20 - Freeform writing ------------ Quickly- I'm Scott Groves - Husband, Father, Loan Officer, Coach, Author, Podcaster, and Blue Belt in Brazilian Jiu-Jitsu. I gave up boxing, where I was 5-0 in amateur fights, when I turned 40. BJJ is safer for old men than getting punched in the head :-) You can find out everything about me HERE: www.LinkTr.ee/ScottLGroves This podcast is paid for and brought to you by.... by me, Scott Groves :-) I am a Mortgage Loan Officer & Loan Officer Coach in real life. It's the money that I earn, from helping home-buyers and home-owners obtain home-loans, that pays for this show. If you, your friends, or your family are looking for a home loan from an honest Loan Officer, please contact me at Scott@ScottGrovesTeam.com or find all my links to connect HERE: www.LinkTr.ee/ScottLGroves I can do the loan for you (our team is licensed in 8 states) - OR - I can refer you to an amazing loan officer in the state where you're searching. ON WITH THE SHOW!!! New Full Episodes are released every THURSDAY at 10:00am and clips are released frequently throughout the week. SO MAKE SURE YOU SUBSCRIBE!!! Don't care for YouTube and prefer listening instead? We got you covered wherever podcasts are found: ----------- Do YOU or SOMEBODY YOU KNOW want to be featured in the podcast? Questions, inquiries, booking a show? Any topics or people you'd like us to cover? Send us an email: scott@ontheedgepodcast.com
Medix Type I, Type II and Type III ambulances deliver the industry's highest possible performance value. Go safely, effectively, and efficiently with ambulance models that provide best-in-class delivery. Learn more at https://medixambulance.com/. Host Sean J. Britton provides an overview of the protections in place to safeguard deposits at banks and credit unions, and consumer protections in place to safeguard against fraudulent debit and credit card purchases. Additionally, you will be presented with three actionable strategies to protect yourself from credit and debit card fraud.
Medix Type I, Type II and Type III ambulances deliver the industry's highest possible performance value. Go safely, effectively, and efficiently with ambulance models that provide best-in-class delivery. Learn more at https://medixambulance.com/. Beyond Lucid Technologies' Jonathon Feit talks with Larkspur (CO) Fire Protection District Chief Stuart Mills. Chief Mills runs an extremely nimble and innovative transporting fire service nestled between Denver and Colorado Springs. This rural department was the first in the U.S. to share real-time consumable data with his hospital partners to participate interactively with a health information exchange. The former Navy man at its helm has a unique management style that empowers every one of his crew members to step up and understand the burdens of leadership.
Medix Type I, Type II and Type III ambulances deliver the industry's highest possible performance value. Go safely, effectively, and efficiently with ambulance models that provide best-in-class delivery. Learn more at https://medixambulance.com/. Eric Chase has a conversation with three-time sudden cardiac arrest survivor Steve Dunn.
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.04.05.535690v1?rss=1 Authors: Kirchenwitz, M., Halfen, J., von Peinen, K., Prettin, S., Kollasser, J., Brakebusch, C. H., Rottner, K., Steffen, A., Stradal, T. Abstract: Salmonella enterica serovar Typhimurium manipulates cellular Rho GTPases for host cell invasion by effector protein translocation via the Type III Secretion System (T3SS). The two Guanine nucleotide exchange (GEF) mimicking factors SopE and -E2 and the inositol phosphate phosphatase (PiPase) SopB activate the Rho GTPases Rac1, Cdc42 and RhoA, thereby mediating bacterial invasion. S. Typhimurium lacking these three effector proteins are largely invasion-defective. Type III secretion is crucial for both early and later phases of the intracellular life of S. Typhimurium. Here we investigated whether and how the small GTPase RhoB, known to localize on endomembrane vesicles and at the invasion site of S. Typhimurium, contributes to bacterial invasion and to subsequent steps relevant for S. Typhimurium lifestyle. We show that RhoB is significantly upregulated within hours of Salmonella infection. This effect depends on the presence of the bacterial effector SopB, but does not require its phosphatase activity. Our data reveal that SopB and RhoB bind to each other, and that RhoB localizes on early phagosomes of intracellular S. Typhimurium. Whereas both SopB and RhoB promote intracellular survival of Salmonella, RhoB is specifically required for Salmonella-induced upregulation of autophagy. Finally, in the absence of RhoB, vacuolar escape and cytosolic hyper-replication of S. Typhimurium is diminished. Our findings thus uncover a role for RhoB in Salmonella-induced autophagy, which supports intracellular survival of the bacterium and is promoted through a positive feedback loop by the Salmonella effector SopB. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
Medix Type I, Type II and Type III ambulances deliver the industry's highest possible performance value. Go safely, effectively, and efficiently with ambulance models that provide best-in-class delivery. Learn more at https://medixambulance.com/. Dov and Raphael delve into some of the challenges and humorous stories that take place in Israel during the spring holiday seasons. They advise how to avoid the pitfalls that many people find themselves in during this time of year. As there currently is a concurrence of three major holidays in Passover, Ramadan, and Easter/Pascha the entire populace is out celebrating the holy and happy time, which means... you guessed it, far more emergency calls. From hiking and water drownings to dehydration and spring/Passover cleaning-related injuries, Dov and Raphael take you behind the scenes into some harrowing calls and talk about how preventable injuries and deaths are really hard to handle.
Chezwick, the 16th person to complete the Eastern Continental Trail and the 5th person to complete the Great Western Loop, takes a load off and sits down with Doc to talk trail. During the discussion, the two range wide and far, covering topics like the state bird of Oregon, the Pyramid of Pain, unique uses for toothpaste in the Himalayas, trail romances ending badly, Doc Campbell's Outpost, Type III fun, and No One and Nothing. You won't believe your ears. --- Support this podcast: https://anchor.fm/johnfreakinmuir/support
“Blood sugar is like comparing water to Kool-Aid – while water flows through our body, Kool-Aid can't flow as well because it's stickier. When we have too much sugar in our bloodstream, our body has a harder time carrying out the processes it needs to.” - Dr. Georgia Nab About 1 in 5 people in the United States have diabetes but don't know it, according to the CDC. While people generally know sugar isn't good for the body, most people don't know why our consumption of it needs to be managed – not eliminated. In today's show, Dr. Michelle Robin invites Dr. Georgia Nab – a Functional Medicine doctor at Your Wellness Connection – to help people understand what's really happening in the body once we consume sugar and why it's then converted to blood sugar. If you have ever wondered what glycemic and glucose mean – or the difference between metabolic syndrome (prediabetes), Type I, Type I.5, Type II, and Type III – this week's episode will give you a clearer understanding of each one in very simple terms. Dr. Nab even dives into how our blood sugar numbers have a tremendous impact on our hormonal levels and anxiety issues in today's world. She encourages listeners that small changes can make a big difference. At the end of the episode, Dr. Nab will also share why sleep and movement matter in managing your blood sugar – ending with some tips that can help you get on a better path toward wellness. About Today's Guest: Dr. Georgia Nab entered the chiropractic industry in 1992 by owning a chiropractic clinic in Wichita, Kansas. From 2012 through 2017, she joined a manufacturing facility in Wisconsin to provide chiropractic care, nutritional counseling, and educational training to the employees at the company's corporate headquarters. While there, she authored her book called 1 Degree of Change, in addition to numerous other publications. In 2015, she graduated with her Master's degree in Human Nutrition and Functional Medicine degree. She is currently an adjunct professor at the University of Western States for their Master's program. Dr. Nab is a Certified Nutrition Specialist from the Board for Nutrition Specialist and works with Affiliated Monitors, an independent monitoring company for professionals. Mentioned in the Episode: Your Wellness Connection 1 Degree of Change book by Dr. Georgia Nab – contact Dr. Nab for a free PDF version
Audio version of my report on existential risk from power-seeking AI. Text here: https://arxiv.org/pdf/2206.13353.pdf. Narration by Type III audio.
Welcome to EO Radio Show – Your Nonprofit Legal Resource. Episode 24 is the second of two parts that discuss supporting organizations as a special type of public charity. All supporting organizations must pass an organizational test, an operational test, a control test, and a relationship test. Supporting organizations are further classified as Type I, Type II, or Type III supporting organizations based on how they satisfy the relationship test. In this episode, I'll recap the basic requirements that apply to all three types and then look more closely at the complex requirements for a Type III supporting organization. Resources: Treasury Regulation Section 1.509(a)-4 Supporting Organizations IRS page Supporting Organizations – Requirements and Types IRS Notice 2014-4 provides interim guidance for Type III supporting organizations to governmental units IRS Form 990 Schedule A and Instructions If you have suggestions for topics you would like us to discuss, please email us at eoradioshow@fbm.com. Additional episodes can be found at EORadioShowByFarella.com. DISCLAIMER: This podcast is for general informational purposes only. It is not intended to be, nor should it be interpreted as, legal advice or opinion.
Welcome to EO Radio Show – Your Nonprofit Legal Resource. This episode is the first of two parts that discuss the definition of supporting organizations as a special type of public charity. All supporting organizations must pass four tests: an organizational test, an operational test, a control test, and a relationship test. Supporting organizations are further classified as Type I, Type II, or Type III supporting organizations based on how they satisfy the relationship test. In this episode, I'll cover the basic requirements that apply to all three types and the additional rules for Type I and Type II. Type III will be covered in more detail in the next episode. So join me now for a dive into the supporting organization rules. Resources: Treasury Regulation Section 1.509(a)-4 Supporting Organizations IRS page Supporting Organizations – Requirements and Types Form 990, Schedule A: Pages 4-7 reporting required for Supporting Organizations If you have suggestions for topics you would like us to discuss, please email us at eoradioshow@fbm.com. Additional episodes can be found at EORadioShowByFarella.com. DISCLAIMER: This podcast is for general informational purposes only. It is not intended to be, nor should it be interpreted as, legal advice or opinion.
Join me in a moving conversation with Rebecca Alexander. In this conversation, Rebecca takes a deep dive into her own life that she has graciously shared in her published book “Not Fade Away: A Memoir of Senses Lost and Found”. Rebecca is a psychotherapist, extreme athlete, and activist. She grew up in Northern California and holds 2 master's degrees from Columbia University. She lives in New York City. She was born with Usher syndrome Type III. In this podcast she shares her incredible story, the importance of feeling emotions and living with adversity, embracing humor in hard circumstances, and surrounding yourself with those who walk beside you. In this podcast, Rebecca shares several stories about her diagnosis of Ushers as well as her journey to getting a cochlear implant. Rebecca sets an example of choosing to be grateful, be happy with what you have today, and be optimistic about tomorrow. Be sure to connect with Rebecca on social media: www.rebalexander.com (can find her book Not Fade Away) www.rebeccaalexandertherapy.com IG: reb_alexander twitter: reb_alexander You can listen to this episode on most podcatchers or at www.3cdigitalmedianetwork.com/empowear-audiology-podcast
Critical Mach Numbers for Magnetohydrodynamic Shocks with Accelerated Particles and Waves by J. Martin Laming. on Tuesday 18 October The first critical fast Mach number is defined for a magnetohydrodynamic shock as the Mach number where the shock transitions from subcritical, laminar, behavior to supercritical behavior, characterized by incident ion reflection from the shock front. The ensuing upstream waves and turbulence are convected downstream leading to a turbulent shock structure. Formally this is the Mach number where plasma resistivity can no longer provide sufficient dissipation to establish a stable shock, and is characterized by the downstream flow speed becoming subsonic. We revisit these calculations, including in the MHD jump conditions terms modeling the plasma energy loss to accelerated particles and the presence of waves associated with these particles. The accelerated particle contributions make an insignificant change, but the associated waves have a more important effect. Upstream waves can be strongly amplified in intensity on passing through the shock, and represent another means of shock dissipation. The presence of such waves therefore increases the first critical fast Mach number, especially at quasi-parallel shock where wave excitation is strongest. These effects may have significance for the solar regions where shock waves accelerate particles and cause Type II and Type III radio bursts, and also contribute to the event-to-event variability of SEP acceleration. arXiv: http://arxiv.org/abs/http://arxiv.org/abs/2210.09365v1
Berberine is a compound found in goldenseal, yellow root, Amur cork tree, Chinese goldthread, prickly poppy, and Californian poppy. I've taken berberine daily for years now. While it doesn't make my Foundational 5 list of the five most essential supplements for health, it would be on my list of the top 10 . This past week, I got a notice for a new paper published in Inflammopharmacology, titled The role of berberine in Covid-19: potential adjunct therapy. The average case of Covid-19 is little more than a strong cold now, but other novel viruses will come along, so I thought it would be helpful to share some of the highlights from this paper. General Health Benefits of Berberine Before addressing the potential effects of berberine in infections like Covid-19, I want to recap its general health benefits. I go into greater detail on these in my article Berberine: Blood Sugar, Body Fat and Other Health Benefits. Research shows berberine: Improves the heart's performance by increasing ejection fraction and left ventricle function in cases of congestive heart failureSupports normal blood pressureIncreases cholesterol excretion and helps improve blood lipid levelsSupports normal blood sugar levels and helps increase glucose transport into muscle cells by acting on Glut-4, which improves insulin sensitivitySupports normal androgen levels in women with PCOSSuppresses the growth of existing fat cells or the development of new fat cellsMay support cognitive health by keeping blood sugar levels in check, thereby reducing the risk of dementia or Alzheimer's Disease (often dubbed Type III diabetes)Enhances the production of brain-derived neurotrophic factor (BDNF), stimulating brain cell production and potentially reducing symptoms of depressionInhibits the brain's reward center after using certain drugs and alcoholImproves diversity of good gut bacteria That's quite a list of health benefits. Now you know why I take berberine every day. Read also: Curcumin: Health Benefits of Turmeric's Key Compound. Berberine and Covid-like Conditions The authors of the new paper summarized berberine's role in COVID-19 as follows: The potential role of BBR in Covid-19 is related to improving the immune response in the early phase of SARS-CoV-2 infection, with suppression of SARS-CoV-2-induced hyper-inflammation in the late phase. Therefore, BBR could be a preventive and therapeutic agent in Covid-19 by targeting inflammatory signaling pathways with suppression of entry/infectivity of SARS-CoV-2.Babalghith AO, et al. Berberine inhibits viral infection early on and may reduce the inflammation-related damage for someone already infected. Such viral infections cause a significant increase in free radicals. With its research-supporter antioxidant effects, berberine may help reduce or prevent free radical damage. The following images come directly from the paper. As you can see, berberine plays multiple roles when tackling inflammation, infection, and free radical damage. Read also: N-acetylcysteine (NAC): Benefits, Usage, and Side Effects. Beyond Covid Covid is no longer seen as the threat it was once was. Most of the public now realizes that it isn't as dangerous as it was made out to be, though there are still a small percentage of people worried enough to wear their masks in public still. I've already seen propaganda promoting the flu's return as this fall's public health threat. Animal research shows that berberine may reduce influenza infection as well. Like any other natural therapy, berberine isn't a miracle cure. If you don't get enough sleep, drink too much alcohol, smoke cigarettes, or are obese, you'll have a much harder time protecting your body from infections. As I often say, No supplement is so good it offsets the effects of a poor diet. No diet is so good it won't benefit from supplementation. With its vast array of health benefits,
Structured type III radio bursts observed in interplanetary space by Immanuel C. Jebaraj et al. on Monday 26 September Context: The last few decades has seen numerous studies dedicated to fine structures of type III radio bursts observed in the metric to decametric wavelengths. Majority of explanations of the structured radio emission involve the propagation of electron beam through the strongly inhomogeneous plasma in the low corona. Until now only few studies of single type III bursts with fine structures, observed in the hecto-kilometric wavelengths, were reported. Aims: Herein we report about existence of numerous structured type III radio bursts observed during the STEREO era by all three WAVES instruments on board STEREO A, B, and Wind. The aim of the study is to report, classify structured type III bursts, and present the characteristics of their fine structures. The final goal is to try to understand the physical mechanism responsible for the generation of structured radio emission. Methods: In this study we used data from all available spacecraft, specifically the STEREO and the Wind spacecraft. We employ 1D density models to obtain the speed of the source of type III radio emission, the electron beam. We also perform spectral analysis of the fine structures in order to compare their characteristics with the metric-decametric fine structures. Results: The presented similarities of the type III fine structures in the metric to decametric and interplanetary wavelengths indicate that the physical processes responsible for the generation of structured type III radio bursts could be the same, at the heights, all the way from the low corona to the interplanetary range. We show that the observed structuring and intermittent nature of the type III bursts can be explained by the variation in the level of density fluctuations, at different distances from the Sun. arXiv: http://arxiv.org/abs/http://arxiv.org/abs/2209.12333v1
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.09.16.508275v1?rss=1 Authors: Kalyanasundar, B., Blonde, G., Spector, A. C., Travers, S. P. Abstract: Recent findings from our laboratory demonstrated that the rostral nucleus of solitary tract (rNST) retains some responsiveness to glutamate (MSG+amiloride-MSGa) and sugars in mice lacking the canonical T1R receptors for these tastants. Here, we recorded from the parabrachial nucleus (PBN) in mice lacking the T1R1+T1R3 heterodimer (KO1+3), using warm stimuli to optimize sugar responses and employing extended concentrations and pharmacological agents to probe mechanisms. MSGa+IMP responses were not synergized in KO1+3 mice but responses to MSGa were similar to those in B6 (WT) mice. Glutamate responses in the neurons tested were unaffected by topical application of an mGluR4 antagonist. PBN T1R-independent sugar responses, including those to concentrated glucose, were more evident than in rNST. Sugar responses were undiminished by phlorizin, an inhibitor of SGLT, a component of a hypothesized alternative glucose-sensing mechanism. There were no sugar/umami "best" neurons in KO1+3 mice, and instead, sugars activated cells that displayed acid and amiloride-insensitive NaCl responses. In WTs, concentrated sugars activated "sugar/umami" cells but also electrolyte-sensitive neurons. The efficacy of hyperosmotic sugars for driving neurons broadly responsive to electrolytes implied an origin from Type III taste bud cells. To test this, we used the carbonic anhydrase (CA) inhibitor dorzolamide (DRZ), previously shown to inhibit amiloride-insensitive sodium responses arising from Type III cells. Dorzolamide had no effect on sugar-elicited responses in WT sugar/umami PBN neurons but strongly suppressed them in WT and KO electrolyte-generalist neurons. These findings suggest a novel T1R-independent mechanism for hyperosmotic sugars, involving a CA-dependent mechanism in Type-III taste bud cells. Copy rights belong to original authors. Visit the link for more info Podcast created by PaperPlayer
Today we are talking about everything collagen! We'll cover what collagen peptides are and the different types of collagen. All this and more in less than 2 minutes. What is collagen? Simply put, collagen is a protein our bodies use to build and repair tissues. It's the most abundant protein found naturally in your body. It provides structural support to our skin, blood vessels, and muscles. It is also found in our bones, teeth, and connective tissues (e.g., tendons, ligaments). We make less collagen as we age, which affects our skin and our joints. But it can be hard to know where to start with so many products available. So before you buy a collagen supplement, there are some important things we think you should know. What are collagen peptides? The collagen found in supplements isn't exactly like the collagen found in your body. Collagen peptides are what is known as hydrolyzed collagen. It's collagen that's been broken down into smaller parts that are easier to digest and dissolve. It's important to know that our body needs different types of collagen to perform many functions. Our bodies are made up of 28 types of collagen. Most of it is type I, II, or III. Type I collagen: Found in your skin, bones, teeth, tendons, ligaments, blood vessels, and eyes. When buying products with Type I collagen- it's good to know that Type I collagen is commonly sourced from (made from) bovine (cow) or porcine (pig) tissues such as bones, tendons, or lungs. Other sources include marine (fish) tissues such as bone, skin, scales, or chicken bones and eggshell membranes (ESM). Type II collagen: Found in your cartilage, the tissue that protects your bones at your joints, your neck, and your spine. When buying products with Type II collagen, keep in mind it's commonly sourced from chicken cartilage. Type III collagen: Found in your muscles and blood vessels. Type III collagen is commonly sourced from bovine tissues. You can find more information at pepties.com. That's peptides without the D. Where we are tying all the peptide information together. Thanks again for listening to The Peptide Podcast. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media. Have a happy, healthy week! Pro Tips We're huge advocates of using daily collagen peptide supplements in your routine to help with skin, nail, bone, and joint health. But what do you know about peptides for health and wellness? Giving yourself a peptide injection can be scary or confusing. But we've got you covered. Check out 6 tips to make peptide injections easier. And, make sure you have the supplies you'll need. This may include syringes, needles, alcohol pads, and a sharps container.
The search term collagen has increased 40% already just in this year alone! So, is all the hype trendy or true? We've done the research and that's the question we answer this week! Did you know that your body naturally produces collagen every day? We dig into why supplementation is even a consideration. Did you know there are several different types of collagen? We've tracked them all down and explain the part each type plays in our body. Is collagen all about less sagging skin? Actually, no it isn't! Tune in to hear about the ways collagen benefits our health. We guarantee some will surprise you. Tune in for more no-nonsense information on what collagens are, how they may benefit your health, and what you need to look for when it comes to the products and foods, you're consuming. Did you know that your body naturally produces collagen every day? We dig into why supplementation is even a consideration. Did you know there are several different types of collagen? We've tracked them all down and explain the part each type plays in our body. Is collagen all about less sagging skin? Actually, no it isn't! Tune in to hear about the ways collagen benefits our health. We guarantee some will surprise you. Tune in for more no-nonsense information on what collagens are, how they may benefit your health, and what you need to look for when it comes to the products and foods, you're consuming. What is collagen? Dictionary result for collagen /ˈkäləjən/ noun the main structural protein found in skin and other connective tissues, widely used in purified form for cosmetic surgical treatments. “vitamin C plays a vital role in the formation of collagen” Different collagen molecules make up about ⅓ of the total protein in a human body Found in bone, skin, muscles, and tendons The substance that connects cells and gives skin elasticity as well as strength Collagen and Aging Your body naturally produces collagen every day. After the age of 25, we break down more collagen than we make. Collagen supplements are an easy way to add more collagen to your diet. Collagen has been shown to reduce wrinkles, keep joints strong and flexible, support strong bones, and increase skin hydration. Why is collagen so good for you? Collagen is vital for maintaining the structure and integrity of your entire body. #1 – Strong Cartilage and Muscles Cartilage is a type of connective tissue that is made up of collagen When you lack collagen, joint instability, stiffness, and pain can result. Likewise, muscles need cartilage to adhere themselves to the ends of bones. This is why muscle aches are one of the most common complaints of individuals with low collagen levels. #2 – Healthy Teeth. Collagen is needed to keep teeth in place in the gums. Loose teeth, toothache, sensitive teeth, and even tooth loss can result from a lack of collagen overall. #3 – Thick Hair Collagen plays an important part in hair growth since it fills in the spaces around each hair follicle. One way to tell if you are collagen deficient is to notice the quality and state of your hair. Dull, thin hair is a sign of low collagen levels. Collagen also helps fight free radicals that can damage hair. #4 – Smooth Skin Wrinkling and cellulite are other unfortunate results of low collagen in the body. Not enough collagen means skin begins to lose elasticity and sag, causing those pesky wrinkles as we age. Cellulite is another telltale sign of low collagen. #5 – Good Gut Health. Collagen helps heal the gut because of its ability to “seal the gut.” Leaky gut has been linked to autoimmune conditions and neurological conditions like autism. Types of Collagens There are over two dozen kinds of collagen, although roughly 85% of the collagen in the body is made up of Type I, II, or III (or a combination of these three types). Type I collagen is the most prevalent type of collagen. It is the substance that makes up the skin, tendons, and bones as well as the structural framework of the organs. It should be your go-to for hair, skin, and nail health, especially for recouping lost collagen stores that occurs naturally as we age. It is also a “well-rounded generalist,” in that it is a good type for supporting overall health. Type I is also found in the digestive tract, which makes it (along with Type II) great for gut healing and repair. Type II collagen is the structural component of cartilage in the body. Because of this, it is great for the joints and to rebuild cartilage in ligaments, tendons, skin, and bones. Type II collagen contains a variety of specific amino acids that are particularly helpful for the body. The first one, again, is glycine, which is beneficial for brain health and metabolism. The second one is proline, which helps clean artery walls. Type II may also be good for the respiratory system, detoxification pathways, and more because it contains arginine, another amino acid that is vital for nitric oxide production. [Note: Nitric oxide is produced in the body and is beneficial for supporting blood flow and lowering blood pressure.] For the most part, Type II collagen is where you want to turn for joint health and possibly even for arthritis support. Type III collagen is typically found where ever Type 1 collagen can be found as well as some other unique places. It is housed in what are called reticular fibers, the substances that make up connective tissue. It is also found in the muscles, bone marrow, blood vessels, and reproductive organs such as the uterus. Type III collagen is also crucial for the healthy functioning of the cardiovascular system. Low Type III collagen has been linked to ruptured blood vessels and can be life-threatening. Type IV collagen helps to strengthen endothelial cells that form the tissue protecting organs as well as muscles and fatty tissue. Endothelial cells also line the majority of the surfaces along the digestive tract and respiratory organs. Type V collagen helps create the surface of cells while Type X helps with bone formation. There are at least a dozen others, all doing their job to keep your body lubricated, moving, and functioning at its best. How to Help Your Body Create Collagen Naturally Eat a diet and live a lifestyle that promotes the healthy synthesizing of your own natural healing and repair mechanisms Avoid UV radiation exposure Do not smoke cigarettes Reduce/Manage stress levels What To Look For In A Collagen Supplement Look for multiple types of collagens Clean sourced and organic Bio-Availability – what is the delivery system – fermented, sprouted Whole food and not synthetic ingredients Contains Vitamin C – Without adequate amounts of dietary vitamin C, the body can't actually form or store collagen Be sure the manufacturer does consistent batch testing for heavy metals Watch out for Natural Flavoring Ingredient List for Organixx Clean Sourced Collagens, Multi-Collagen Blend: Hydrolyzed Grass Fed Pasture-Raised Bovine Collagen Peptides, Bovine Bone Broth Hydrolyzed Protein, Chicken Bone Broth Collagen Concentrate, Clean Marine® Wild Caught Hydrolyzed Fish Collagen Peptides, Eggshell Membrane Collagen, Acerola Cherry (natural source of Vitamin C), Camu Camu (natural source of Vitamin C), Silica from Organic Horsetail, Zinc Gluconate, Fulvic Acid, and Pyroxidine Hydrochloride (Vitamin B6). Natural Flavors – Buyer Beware Important to note, a governmental or independent agency does not approve or oversee the safety of the food flavors. Resources: Organixx Clean Sourced Collagens All Collagen articles and recipes Collagen 101: What It Is and Why Your Body Needs It The Benefits of Collagen for Healthy Skin & Joints (+ 5 Ways to Make More of It) 12 Amazing Benefits of Collagen for Health (and Beauty) Understanding Collagen: The 3 Main Types of Collagen & Their Unique Health Benefits 5 Ways Collagen Can Help Soothe the Gut The Collagen-Boosting Benefits of Zinc Hair Loss or Thinning? Studies Show Collagen Can Help Vitamin C and Collagen: What's the Connection? Collagen: A Natural Solution for Joint Pain? How Collagen Improves Skin Health and Firmness Food Babe - Vani Hari The “Natural” vs. “Natural Flavors” Conflict in Food Labeling: A Regulatory Viewpoint. A randomized, double-blind, multicenter, controlled clinical trial of chicken type II collagen in patients with rheumatoid arthritis Effect of Orally Administered Collagen Peptides from Bovine Bone on Skin Aging in Chronologically Aged Mice An Overview of the Beneficial Effects of Hydrolysed Collagen as a Nutraceutical on Skin Properties: Scientific Background and Clinical Studies Dietary Supplementation with Specific Collagen Peptides Has a Body Mass Index-Dependent Beneficial Effect on Cellulite Morphology 24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain
The search term collagen has increased 40% already just in this year alone! So, is all the hype trendy or true? We've done the research and that's the question we answer this week! Did you know that your body naturally produces collagen every day? We dig into why supplementation is even a consideration. Did you know there are several different types of collagen? We've tracked them all down and explain the part each type plays in our body. Is collagen all about less sagging skin? Actually, no it isn't! Tune in to hear about the ways collagen benefits our health. We guarantee some will surprise you. Tune in for more no-nonsense information on what collagens are, how they may benefit your health, and what you need to look for when it comes to the products and foods, you're consuming. Did you know that your body naturally produces collagen every day? We dig into why supplementation is even a consideration. Did you know there are several different types of collagen? We've tracked them all down and explain the part each type plays in our body. Is collagen all about less sagging skin? Actually, no it isn't! Tune in to hear about the ways collagen benefits our health. We guarantee some will surprise you. Tune in for more no-nonsense information on what collagens are, how they may benefit your health, and what you need to look for when it comes to the products and foods, you're consuming. What is collagen? Dictionary result for collagen /ˈkäləjən/ noun the main structural protein found in skin and other connective tissues, widely used in purified form for cosmetic surgical treatments. “vitamin C plays a vital role in the formation of collagen” Different collagen molecules make up about ⅓ of the total protein in a human body Found in bone, skin, muscles, and tendons The substance that connects cells and gives skin elasticity as well as strength Collagen and Aging Your body naturally produces collagen every day. After the age of 25, we break down more collagen than we make. Collagen supplements are an easy way to add more collagen to your diet. Collagen has been shown to reduce wrinkles, keep joints strong and flexible, support strong bones, and increase skin hydration. Why is collagen so good for you? Collagen is vital for maintaining the structure and integrity of your entire body. #1 – Strong Cartilage and Muscles Cartilage is a type of connective tissue that is made up of collagen When you lack collagen, joint instability, stiffness, and pain can result. Likewise, muscles need cartilage to adhere themselves to the ends of bones. This is why muscle aches are one of the most common complaints of individuals with low collagen levels. #2 – Healthy Teeth. Collagen is needed to keep teeth in place in the gums. Loose teeth, toothache, sensitive teeth, and even tooth loss can result from a lack of collagen overall. #3 – Thick Hair Collagen plays an important part in hair growth since it fills in the spaces around each hair follicle. One way to tell if you are collagen deficient is to notice the quality and state of your hair. Dull, thin hair is a sign of low collagen levels. Collagen also helps fight free radicals that can damage hair. #4 – Smooth Skin Wrinkling and cellulite are other unfortunate results of low collagen in the body. Not enough collagen means skin begins to lose elasticity and sag, causing those pesky wrinkles as we age. Cellulite is another telltale sign of low collagen. #5 – Good Gut Health. Collagen helps heal the gut because of its ability to “seal the gut.” Leaky gut has been linked to autoimmune conditions and neurological conditions like autism. Types of Collagens There are over two dozen kinds of collagen, although roughly 85% of the collagen in the body is made up of Type I, II, or III (or a combination of these three types). Type I collagen is the most prevalent type of collagen. It is the substance that makes up the skin, tendons, and bones as well as the structural framework of the organs. It should be your go-to for hair, skin, and nail health, especially for recouping lost collagen stores that occurs naturally as we age. It is also a “well-rounded generalist,” in that it is a good type for supporting overall health. Type I is also found in the digestive tract, which makes it (along with Type II) great for gut healing and repair. Type II collagen is the structural component of cartilage in the body. Because of this, it is great for the joints and to rebuild cartilage in ligaments, tendons, skin, and bones. Type II collagen contains a variety of specific amino acids that are particularly helpful for the body. The first one, again, is glycine, which is beneficial for brain health and metabolism. The second one is proline, which helps clean artery walls. Type II may also be good for the respiratory system, detoxification pathways, and more because it contains arginine, another amino acid that is vital for nitric oxide production. [Note: Nitric oxide is produced in the body and is beneficial for supporting blood flow and lowering blood pressure.] For the most part, Type II collagen is where you want to turn for joint health and possibly even for arthritis support. Type III collagen is typically found where ever Type 1 collagen can be found as well as some other unique places. It is housed in what are called reticular fibers, the substances that make up connective tissue. It is also found in the muscles, bone marrow, blood vessels, and reproductive organs such as the uterus. Type III collagen is also crucial for the healthy functioning of the cardiovascular system. Low Type III collagen has been linked to ruptured blood vessels and can be life-threatening. Type IV collagen helps to strengthen endothelial cells that form the tissue protecting organs as well as muscles and fatty tissue. Endothelial cells also line the majority of the surfaces along the digestive tract and respiratory organs. Type V collagen helps create the surface of cells while Type X helps with bone formation. There are at least a dozen others, all doing their job to keep your body lubricated, moving, and functioning at its best. How to Help Your Body Create Collagen Naturally Eat a diet and live a lifestyle that promotes the healthy synthesizing of your own natural healing and repair mechanisms Avoid UV radiation exposure Do not smoke cigarettes Reduce/Manage stress levels What To Look For In A Collagen Supplement Look for multiple types of collagens Clean sourced and organic Bio-Availability – what is the delivery system – fermented, sprouted Whole food and not synthetic ingredients Contains Vitamin C – Without adequate amounts of dietary vitamin C, the body can't actually form or store collagen Be sure the manufacturer does consistent batch testing for heavy metals Watch out for Natural Flavoring Ingredient List for Organixx Clean Sourced Collagens, Multi-Collagen Blend: Hydrolyzed Grass Fed Pasture-Raised Bovine Collagen Peptides, Bovine Bone Broth Hydrolyzed Protein, Chicken Bone Broth Collagen Concentrate, Clean Marine® Wild Caught Hydrolyzed Fish Collagen Peptides, Eggshell Membrane Collagen, Acerola Cherry (natural source of Vitamin C), Camu Camu (natural source of Vitamin C), Silica from Organic Horsetail, Zinc Gluconate, Fulvic Acid, and Pyroxidine Hydrochloride (Vitamin B6). Natural Flavors – Buyer Beware Important to note, a governmental or independent agency does not approve or oversee the safety of the food flavors. Resources: Organixx Clean Sourced Collagens All Collagen articles and recipes Collagen 101: What It Is and Why Your Body Needs It The Benefits of Collagen for Healthy Skin & Joints (+ 5 Ways to Make More of It) 12 Amazing Benefits of Collagen for Health (and Beauty) Understanding Collagen: The 3 Main Types of Collagen & Their Unique Health Benefits 5 Ways Collagen Can Help Soothe the Gut The Collagen-Boosting Benefits of Zinc Hair Loss or Thinning? Studies Show Collagen Can Help Vitamin C and Collagen: What's the Connection? Collagen: A Natural Solution for Joint Pain? How Collagen Improves Skin Health and Firmness Food Babe - Vani Hari The “Natural” vs. “Natural Flavors” Conflict in Food Labeling: A Regulatory Viewpoint. A randomized, double-blind, multicenter, controlled clinical trial of chicken type II collagen in patients with rheumatoid arthritis Effect of Orally Administered Collagen Peptides from Bovine Bone on Skin Aging in Chronologically Aged Mice An Overview of the Beneficial Effects of Hydrolysed Collagen as a Nutraceutical on Skin Properties: Scientific Background and Clinical Studies Dietary Supplementation with Specific Collagen Peptides Has a Body Mass Index-Dependent Beneficial Effect on Cellulite Morphology 24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain
In this episode, Jill and Dr. Cathy Pederson discuss the ins and outs of Ehlers-Danlos Syndrome (EDS), Type III (hypermobile) and its relevance for many POTS patients. Many POTS patients also have EDS, a genetic mutation of one or more genes that code for the protein collagen. How can that defect cause so much havoc? To follow along with the diagnosis criteria, please check out this page: https://www.standinguptopots.org/resources/pots-causes You can read the transcript for this episode here: https://tinyurl.com/2p928zz3 Please click the "subscribe" button so that you don't miss an episode of The POTScast. Subscribing also helps us reach other people just like you! If you liked this episode, we hope you will help to support our production costs by donating to Standing Up to POTS at https://www.standinguptopots.org/donate Tell us what you think of The POTScast or send us your idea at info@standinguptopots.org! Find out more about Standing Up to POTS! Check us out on our Website: www.standinguptopots.org Facebook: https://www.facebook.com/standinguptopots/ Instagram: https://www.instagram.com/standinguptopots/ Twitter: https://twitter.com/POTSActivist Pintrest: https://www.pinterest.com/TheStandingUpToPOTS/ Medical Disclaimer: The information provided here is not intended to serve as professional medical advice, diagnosis, or treatment. If you have health related issues, please contact a qualified health professional to get the personalized assessment, advice, and treatment that you need. Standing Up to POTS will not be liable for any direct, indirect, or other damages arising from the use of this podcast.
In this episode, Jill and Dr. Cathy Pederson discuss the ins and outs of Ehlers-Danlos Syndrome (EDS), Type III (hypermobile) and its relevance for many POTS patients. Many POTS patients also have EDS, a genetic mutation of one or more genes that code for the protein collagen. How can that defect cause so much havoc? To follow along with the diagnosis criteria, please check out this page: https://www.standinguptopots.org/resources/pots-causes You can read the transcript for this episode here: https://tinyurl.com/2p928zz3 Please click the "subscribe" button so that you don't miss an episode of The POTScast. Subscribing also helps us reach other people just like you! If you liked this episode, we hope you will help to support our production costs by donating to Standing Up to POTS at https://www.standinguptopots.org/donate Tell us what you think of The POTScast or send us your idea at info@standinguptopots.org! Find out more about Standing Up to POTS! Check us out on our Website: www.standinguptopots.org Facebook: https://www.facebook.com/standinguptopots/ Instagram: https://www.instagram.com/standinguptopots/ Twitter: https://twitter.com/POTSActivist Pintrest: https://www.pinterest.com/TheStandingUpToPOTS/ Medical Disclaimer: The information provided here is not intended to serve as professional medical advice, diagnosis, or treatment. If you have health related issues, please contact a qualified health professional to get the personalized assessment, advice, and treatment that you need. Standing Up to POTS will not be liable for any direct, indirect, or other damages arising from the use of this podcast.
In this episode, Jill and Dr. Cathy Pederson discuss the ins and outs of Ehlers-Danlos Syndrome (EDS), Type III (hypermobile) and its relevance for many POTS patients. Many POTS patients also have EDS, a genetic mutation of one or more genes that code for the protein collagen. How can that defect cause so much havoc? To follow along with the diagnosis criteria, please check out this page: https://www.standinguptopots.org/resources/pots-causes You can read the transcript for this episode here: https://tinyurl.com/2p928zz3 Please click the "subscribe" button so that you don't miss an episode of The POTScast. Subscribing also helps us reach other people just like you! If you liked this episode, we hope you will help to support our production costs by donating to Standing Up to POTS at https://www.standinguptopots.org/donate Tell us what you think of The POTScast or send us your idea at info@standinguptopots.org! Find out more about Standing Up to POTS! Check us out on our Website: www.standinguptopots.org Facebook: https://www.facebook.com/standinguptopots/ Instagram: https://www.instagram.com/standinguptopots/ Twitter: https://twitter.com/POTSActivist Pintrest: https://www.pinterest.com/TheStandingUpToPOTS/ Medical Disclaimer: The information provided here is not intended to serve as professional medical advice, diagnosis, or treatment. If you have health related issues, please contact a qualified health professional to get the personalized assessment, advice, and treatment that you need. Standing Up to POTS will not be liable for any direct, indirect, or other damages arising from the use of this podcast.
In Episode 041, MetalFRO and Addicted take on a classic that made the move from the arcade to home consoles for it's third installment, R-Type III!
On this podcast I share a story about #MyVery1stVW Squarback (Can be seen under that hashtag on Instagram) I've owned my Volkswagen for over 35 years! The car got totaled back in the 90's but somehow some way, I was able to keep it on the road for over 3 decades!!!! Yikes! Did I mention this is my very 1st Car @_@ Never had a car payment, never will :P Oya this episode started 3 days after Type III day on Oct 3rd, 2021. I finally finished it 3 months after, cuz we take (type) 3 seriously :) Honest²
In this episode, I speak to Alison Cossons, a former occupational therapist, who has hypermobile Ehlers Danlos syndrome, which was evident from birth however she was only diagnosed in her late 30s alongside her young son. Alison is a regular Nordic Walker with Nordic4 and attends classes run by both Katie Atkins and Emma Webb. Alison mentions this YouTube clip in her interview: https://youtu.be/YxfkWAPMdg8 Jason Perry - Practical Pacing and Fatigue Management within the Ehlers Danlos Society YouTube account. Further ResourcesThe Ehlers Danlos Society - www.ehlers-danlos.comMedical journal article about hEDS, written by members of the International Consortium on Ehlers-Danlos syndromes and hypermobility spectrum disorders: Hypermobile Ehlers-Danlos syndrome (a.k.a. Ehlers-Danlos syndrome Type III and Ehlers-Danlos syndrome hypermobility type): Clinical description and natural historyEhlers-Danlos Support UK https://www.ehlers-danlos.org/. HMSA - Hypermobility Syndrome Association https://www.hypermobility.org/. Alison's family will be forever grateful to Professor Rodney Grahame (https://www.ehlers-danlos.com/rodney-grahame/ ) who made these diagnoses for them, and later for Alison's daughter. Alison and her family continue to receive online and hydrotherapy physiotherapy from Rachel Lewis (www.physio-hydro.com) who has known Alison following the birth of Alison's son. Find An Instructorhttps://britishnordicwalking.org.uk/apps/store-locatorIf you have enjoyed this podcast, I would be very grateful if you could show your support by buying me a coffee! This enables me to continue producing these podcasts, as it will go towards covering the server and podcast platform licenses. Not only is Nordic Walking a whole body workout, but it is also one of the safest and most sociable way to exercise. Classes always finish up in a cafe enjoying a coffee together. Many thanks, Mary xI'm Mary Tweed, a British Nordic Walking instructor with Nordic Walking East Anglia. If you wish to share your story, do get in touch by emailing hello@walkingonairpodcast.co.uk#NordicWalking #WeAreNordicWalking #BritNW #BritishNordicWalking #INWA #NordicWalkingEastAnglia #onwf #nordicwalkinguk #walx #nordicwalkingaustralia #nordixx #urbanpoling #ANWA #anwaUSA #nordicwalkingnewzealand #nordicpolewalking #nordicpolewalkingnovascotia #nordicacademy #polewalking #lekipoles #exelpoles #fitnesswalking #skiwalking #polewalking #greengym #mentalhealth #mentalwellbeing #weightloss #posture #useitorloseit #activeageing #nutritiousmovement #exerciseanywhere #BetterHealth #GreatOutdoors #fitnessforallages #walkwithease Support the show (https://www.buymeacoffee.com/walkingonair)Support the show (https://www.buymeacoffee.com/walkingonair)
Episode 384. Topic: Type III diabetes. Theme: Diabetes. Did you know there was a type III diabetes? How is it related to type I and II? What are its effects? Do current anti-diabetic drugs also work for it? Twitter: @3minutelessonEmail: 3minutelesson@gmail.comInstagram: 3minutelessonFacebook: 3minutelessonNew episode every Monday, Wednesday, and Friday! Find us everywhere podcasts are found.
Dennis Mossburg has a worked over 17 years in corrections and is an Incident Command System (ICS), Type III Operations Section Chief. Dennis is also the founder of Grey Moose Leadership Group. As a leader, he has supervised staff in corrections, supervising their day-to-day activities and emergency response. As a member of a Type III incident management team, Dennis has responded to emergencies involving contaminated water incidents, computer system breeches, the Kilauea Volcano in Hawai'i and Hurricane Florence in North Carolina. Linked In: https://www.linkedin.com/in/dennis-mossburg/ Facebook: https://www.facebook.com/dennis.mossburg.1 Facebook Page: Grey Moose Leadership Group, LLC Youtube: https://www.youtube.com/channel/UCfYYXlD1TGhtHkjIGALckGg --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app --- Send in a voice message: https://anchor.fm/marieoldfield/message Support this podcast: https://anchor.fm/marieoldfield/support
The search term collagen has increased 40% already just in this year alone! So, is all the hype trendy or true? We've done the research and that's the question we answer this week! Did you know that your body naturally produces collagen every day? We dig into why supplementation is even a consideration. Did you know there are several different types of collagen? We've tracked them all down and explain the part each type plays in our body. Is collagen all about less sagging skin? Actually, no it isn't! Tune in to hear about the ways collagen benefits our health. We guarantee some will surprise you. Tune in for more no-nonsense information on what collagens are, how they may benefit your health, and what you need to look for when it comes to the products and foods, you're consuming. Did you know that your body naturally produces collagen every day? We dig into why supplementation is even a consideration. Did you know there are several different types of collagen? We've tracked them all down and explain the part each type plays in our body. Is collagen all about less sagging skin? Actually, no it isn't! Tune in to hear about the ways collagen benefits our health. We guarantee some will surprise you. Tune in for more no-nonsense information on what collagens are, how they may benefit your health, and what you need to look for when it comes to the products and foods, you're consuming. What is collagen? Dictionary result for collagen /ˈkäləjən/ noun the main structural protein found in skin and other connective tissues, widely used in purified form for cosmetic surgical treatments. “vitamin C plays a vital role in the formation of collagen” Different collagen molecules make up about ⅓ of the total protein in a human body Found in bone, skin, muscles, and tendons The substance that connects cells and gives skin elasticity as well as strength Collagen and Aging Your body naturally produces collagen every day. After the age of 25, we break down more collagen than we make. Collagen supplements are an easy way to add more collagen to your diet. Collagen has been shown to reduce wrinkles, keep joints strong and flexible, support strong bones, and increase skin hydration. Why is collagen so good for you? Collagen is vital for maintaining the structure and integrity of your entire body. #1 – Strong Cartilage and Muscles Cartilage is a type of connective tissue that is made up of collagen When you lack collagen, joint instability, stiffness, and pain can result. Likewise, muscles need cartilage to adhere themselves to the ends of bones. This is why muscle aches are one of the most common complaints of individuals with low collagen levels. #2 – Healthy Teeth. Collagen is needed to keep teeth in place in the gums. Loose teeth, toothache, sensitive teeth, and even tooth loss can result from a lack of collagen overall. #3 – Thick Hair Collagen plays an important part in hair growth since it fills in the spaces around each hair follicle. One way to tell if you are collagen deficient is to notice the quality and state of your hair. Dull, thin hair is a sign of low collagen levels. Collagen also helps fight free radicals that can damage hair. #4 – Smooth Skin Wrinkling and cellulite are other unfortunate results of low collagen in the body. Not enough collagen means skin begins to lose elasticity and sag, causing those pesky wrinkles as we age. Cellulite is another telltale sign of low collagen. #5 – Good Gut Health. Collagen helps heal the gut because of its ability to “seal the gut.” Leaky gut has been linked to autoimmune conditions and neurological conditions like autism. Types of Collagens There are over two dozen kinds of collagen, although roughly 85% of the collagen in the body is made up of Type I, II, or III (or a combination of these three types). Type I collagen is the most prevalent type of collagen. It is the substance that makes up the skin, tendons, and bones as well as the structural framework of the organs. It should be your go-to for hair, skin, and nail health, especially for recouping lost collagen stores that occurs naturally as we age. It is also a “well-rounded generalist,” in that it is a good type for supporting overall health. Type I is also found in the digestive tract, which makes it (along with Type II) great for gut healing and repair. Type II collagen is the structural component of cartilage in the body. Because of this, it is great for the joints and to rebuild cartilage in ligaments, tendons, skin, and bones. Type II collagen contains a variety of specific amino acids that are particularly helpful for the body. The first one, again, is glycine, which is beneficial for brain health and metabolism. The second one is proline, which helps clean artery walls. Type II may also be good for the respiratory system, detoxification pathways, and more because it contains arginine, another amino acid that is vital for nitric oxide production. [Note: Nitric oxide is produced in the body and is beneficial for supporting blood flow and lowering blood pressure.] For the most part, Type II collagen is where you want to turn for joint health and possibly even for arthritis support. Type III collagen is typically found where ever Type 1 collagen can be found as well as some other unique places. It is housed in what are called reticular fibers, the substances that make up connective tissue. It is also found in the muscles, bone marrow, blood vessels, and reproductive organs such as the uterus. Type III collagen is also crucial for the healthy functioning of the cardiovascular system. Low Type III collagen has been linked to ruptured blood vessels and can be life-threatening. Type IV collagen helps to strengthen endothelial cells that form the tissue protecting organs as well as muscles and fatty tissue. Endothelial cells also line the majority of the surfaces along the digestive tract and respiratory organs. Type V collagen helps create the surface of cells while Type X helps with bone formation. There are at least a dozen others, all doing their job to keep your body lubricated, moving, and functioning at its best. How to Help Your Body Create Collagen Naturally Eat a diet and live a lifestyle that promotes the healthy synthesizing of your own natural healing and repair mechanisms Avoid UV radiation exposure Do not smoke cigarettes Reduce/Manage stress levels What To Look For In A Collagen Supplement Look for multiple types of collagens Clean sourced and organic Bio-Availability – what is the delivery system – fermented, sprouted Whole food and not synthetic ingredients Contains Vitamin C – Without adequate amounts of dietary vitamin C, the body can't actually form or store collagen Be sure the manufacturer does consistent batch testing for heavy metals Watch out for Natural Flavoring Ingredient List for Organixx Clean Sourced Collagens, Multi-Collagen Blend: Hydrolyzed Grass Fed Pasture-Raised Bovine Collagen Peptides, Bovine Bone Broth Hydrolyzed Protein, Chicken Bone Broth Collagen Concentrate, Clean Marine® Wild Caught Hydrolyzed Fish Collagen Peptides, Eggshell Membrane Collagen, Acerola Cherry (natural source of Vitamin C), Camu Camu (natural source of Vitamin C), Silica from Organic Horsetail, Zinc Gluconate, Fulvic Acid, and Pyroxidine Hydrochloride (Vitamin B6). Natural Flavors – Buyer Beware Important to note, a governmental or independent agency does not approve or oversee the safety of the food flavors. Resources: Organixx Clean Sourced Collagens All Collagen articles and recipes Collagen 101: What It Is and Why Your Body Needs It The Benefits of Collagen for Healthy Skin & Joints (+ 5 Ways to Make More of It) 12 Amazing Benefits of Collagen for Health (and Beauty) Understanding Collagen: The 3 Main Types of Collagen & Their Unique Health Benefits 5 Ways Collagen Can Help Soothe the Gut The Collagen-Boosting Benefits of Zinc Hair Loss or Thinning? Studies Show Collagen Can Help Vitamin C and Collagen: What's the Connection? Collagen: A Natural Solution for Joint Pain? How Collagen Improves Skin Health and Firmness Food Babe - Vani Hari The “Natural” vs. “Natural Flavors” Conflict in Food Labeling: A Regulatory Viewpoint. A randomized, double-blind, multicenter, controlled clinical trial of chicken type II collagen in patients with rheumatoid arthritis Effect of Orally Administered Collagen Peptides from Bovine Bone on Skin Aging in Chronologically Aged Mice An Overview of the Beneficial Effects of Hydrolysed Collagen as a Nutraceutical on Skin Properties: Scientific Background and Clinical Studies Dietary Supplementation with Specific Collagen Peptides Has a Body Mass Index-Dependent Beneficial Effect on Cellulite Morphology 24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain
The search term collagen has increased 40% already just in this year alone! So, is all the hype trendy or true? We've done the research and that's the question we answer this week! Did you know that your body naturally produces collagen every day? We dig into why supplementation is even a consideration. Did you know there are several different types of collagen? We've tracked them all down and explain the part each type plays in our body. Is collagen all about less sagging skin? Actually, no it isn't! Tune in to hear about the ways collagen benefits our health. We guarantee some will surprise you. Tune in for more no-nonsense information on what collagens are, how they may benefit your health, and what you need to look for when it comes to the products and foods, you're consuming. Did you know that your body naturally produces collagen every day? We dig into why supplementation is even a consideration. Did you know there are several different types of collagen? We've tracked them all down and explain the part each type plays in our body. Is collagen all about less sagging skin? Actually, no it isn't! Tune in to hear about the ways collagen benefits our health. We guarantee some will surprise you. Tune in for more no-nonsense information on what collagens are, how they may benefit your health, and what you need to look for when it comes to the products and foods, you're consuming. What is collagen? Dictionary result for collagen /ˈkäləjən/ noun the main structural protein found in skin and other connective tissues, widely used in purified form for cosmetic surgical treatments. “vitamin C plays a vital role in the formation of collagen” Different collagen molecules make up about ⅓ of the total protein in a human body Found in bone, skin, muscles, and tendons The substance that connects cells and gives skin elasticity as well as strength Collagen and Aging Your body naturally produces collagen every day. After the age of 25, we break down more collagen than we make. Collagen supplements are an easy way to add more collagen to your diet. Collagen has been shown to reduce wrinkles, keep joints strong and flexible, support strong bones, and increase skin hydration. Why is collagen so good for you? Collagen is vital for maintaining the structure and integrity of your entire body. #1 – Strong Cartilage and Muscles Cartilage is a type of connective tissue that is made up of collagen When you lack collagen, joint instability, stiffness, and pain can result. Likewise, muscles need cartilage to adhere themselves to the ends of bones. This is why muscle aches are one of the most common complaints of individuals with low collagen levels. #2 – Healthy Teeth. Collagen is needed to keep teeth in place in the gums. Loose teeth, toothache, sensitive teeth, and even tooth loss can result from a lack of collagen overall. #3 – Thick Hair Collagen plays an important part in hair growth since it fills in the spaces around each hair follicle. One way to tell if you are collagen deficient is to notice the quality and state of your hair. Dull, thin hair is a sign of low collagen levels. Collagen also helps fight free radicals that can damage hair. #4 – Smooth Skin Wrinkling and cellulite are other unfortunate results of low collagen in the body. Not enough collagen means skin begins to lose elasticity and sag, causing those pesky wrinkles as we age. Cellulite is another telltale sign of low collagen. #5 – Good Gut Health. Collagen helps heal the gut because of its ability to “seal the gut.” Leaky gut has been linked to autoimmune conditions and neurological conditions like autism. Types of Collagens There are over two dozen kinds of collagen, although roughly 85% of the collagen in the body is made up of Type I, II, or III (or a combination of these three types). Type I collagen is the most prevalent type of collagen. It is the substance that makes up the skin, tendons, and bones as well as the structural framework of the organs. It should be your go-to for hair, skin, and nail health, especially for recouping lost collagen stores that occurs naturally as we age. It is also a “well-rounded generalist,” in that it is a good type for supporting overall health. Type I is also found in the digestive tract, which makes it (along with Type II) great for gut healing and repair. Type II collagen is the structural component of cartilage in the body. Because of this, it is great for the joints and to rebuild cartilage in ligaments, tendons, skin, and bones. Type II collagen contains a variety of specific amino acids that are particularly helpful for the body. The first one, again, is glycine, which is beneficial for brain health and metabolism. The second one is proline, which helps clean artery walls. Type II may also be good for the respiratory system, detoxification pathways, and more because it contains arginine, another amino acid that is vital for nitric oxide production. [Note: Nitric oxide is produced in the body and is beneficial for supporting blood flow and lowering blood pressure.] For the most part, Type II collagen is where you want to turn for joint health and possibly even for arthritis support. Type III collagen is typically found where ever Type 1 collagen can be found as well as some other unique places. It is housed in what are called reticular fibers, the substances that make up connective tissue. It is also found in the muscles, bone marrow, blood vessels, and reproductive organs such as the uterus. Type III collagen is also crucial for the healthy functioning of the cardiovascular system. Low Type III collagen has been linked to ruptured blood vessels and can be life-threatening. Type IV collagen helps to strengthen endothelial cells that form the tissue protecting organs as well as muscles and fatty tissue. Endothelial cells also line the majority of the surfaces along the digestive tract and respiratory organs. Type V collagen helps create the surface of cells while Type X helps with bone formation. There are at least a dozen others, all doing their job to keep your body lubricated, moving, and functioning at its best. How to Help Your Body Create Collagen Naturally Eat a diet and live a lifestyle that promotes the healthy synthesizing of your own natural healing and repair mechanisms Avoid UV radiation exposure Do not smoke cigarettes Reduce/Manage stress levels What To Look For In A Collagen Supplement Look for multiple types of collagens Clean sourced and organic Bio-Availability – what is the delivery system – fermented, sprouted Whole food and not synthetic ingredients Contains Vitamin C – Without adequate amounts of dietary vitamin C, the body can't actually form or store collagen Be sure the manufacturer does consistent batch testing for heavy metals Watch out for Natural Flavoring Ingredient List for Organixx Clean Sourced Collagens, Multi-Collagen Blend: Hydrolyzed Grass Fed Pasture-Raised Bovine Collagen Peptides, Bovine Bone Broth Hydrolyzed Protein, Chicken Bone Broth Collagen Concentrate, Clean Marine® Wild Caught Hydrolyzed Fish Collagen Peptides, Eggshell Membrane Collagen, Acerola Cherry (natural source of Vitamin C), Camu Camu (natural source of Vitamin C), Silica from Organic Horsetail, Zinc Gluconate, Fulvic Acid, and Pyroxidine Hydrochloride (Vitamin B6). Natural Flavors – Buyer Beware Important to note, a governmental or independent agency does not approve or oversee the safety of the food flavors. Resources: Organixx Clean Sourced Collagens All Collagen articles and recipes Collagen 101: What It Is and Why Your Body Needs It The Benefits of Collagen for Healthy Skin & Joints (+ 5 Ways to Make More of It) 12 Amazing Benefits of Collagen for Health (and Beauty) Understanding Collagen: The 3 Main Types of Collagen & Their Unique Health Benefits 5 Ways Collagen Can Help Soothe the Gut The Collagen-Boosting Benefits of Zinc Hair Loss or Thinning? Studies Show Collagen Can Help Vitamin C and Collagen: What's the Connection? Collagen: A Natural Solution for Joint Pain? How Collagen Improves Skin Health and Firmness Food Babe - Vani Hari The “Natural” vs. “Natural Flavors” Conflict in Food Labeling: A Regulatory Viewpoint. A randomized, double-blind, multicenter, controlled clinical trial of chicken type II collagen in patients with rheumatoid arthritis Effect of Orally Administered Collagen Peptides from Bovine Bone on Skin Aging in Chronologically Aged Mice An Overview of the Beneficial Effects of Hydrolysed Collagen as a Nutraceutical on Skin Properties: Scientific Background and Clinical Studies Dietary Supplementation with Specific Collagen Peptides Has a Body Mass Index-Dependent Beneficial Effect on Cellulite Morphology 24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain
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Dream for you, reality for us. For thousands of years, Devil has been using his sons and helpers to defeat humanity. Sometimes it unleashesefreets on us. Sometimes it gets stuck in us in exchange for our own mistakes... Does our Allah leave mankind helpless? Of course Allah hasn't gave permission this. Allah never authorizes. The inhabitants of the spiritual realm "prophets and guardians" are sent to the Muslims and choosing, teaching them various secret Sciences and methods of fighting "Devil". Aim of These sciences are treatment of diseases, besides illuminating details about the evils that "Jinn and demons".Here you will find the breathtaking experiences of life devoted years to healing people for Allah's consent and then will be found their deep knowledge within the scope of ledun's science. Muslims will have evidence really source of information against the army of Devil and efreet. How can you fight an enemy you don't know? Facebook: https://www.facebook.com/SynergyKendiyas İnstagram: https://instagram.com/synergykendiyas Youtube: https://www.youtube.com/channel/UC_xe-4OhrGjeQkX9dWA96fQ
požadavky - co nejnižší hmotnost, nezávislost na napájecím napětí Typy - Laptop (na klín) - m < 5kg, A3, velikost běžného kufříku, notebook, m < 3 kg, A4, palmtop - do dlaně, m < 1 kg, A5 HISTORIE - IBM PC Portable (1983), velký a těžký zdroj - neuplatnil se, větší popularita po 1985 - LCD displej 640 x 200, obrazovka zabudovaná do základní jednotky počítače (u stolních pc skříň) PCMCIA (Personal Memory Card International Association) - podpora Hot Plug / Swapping a Plug & Play - nástupcem Express Card - 3 typy - Type I - tloušťka 3,3 mm - paměti EEPROM (Electrically Erasable Programmable Read-Only Memory), ROM/OTP (One Time Programmable), RAM, Type II, Type III - hot swapping pevného disku, Card Bus - pozdější 32 bitová verze PCMCIA - disponuje funkcí bus mastering - umožňuje zařízení na kartě přístup přímo do paměti POWER MANAGEMENT - nastavení v BIOSu - vypnutí do pohotovostního režimu (stand-by, sleep mode, režim spánku) - vypne se pevný disk a obrazovka, hibernace - stav paměti, procesoru atp - odloží se na HDD/SSD - po dalším zapnutí se automaticky obnoví, nastavení dalšího rozbíhání HDD (rozbíhání energeticky náročné), monochromatický režim, možnost vypnutí napájení periferií, když jsou nevyužité, nízkonapěťový procesor AKUMULÁTORY - požadavky kapacita/objem a hmotnost, x samovybíjení, x paměťový efekt, dlouhá životnost Typy: NiCd, NiMH, Li-Ion, Li-Po LAPTOP (notebook) - Sloty - rozšíření pomocí dokovací stanice (docking station), sběrnice PCI standard/express, Procesor - nízké napětí, Klávesnice - Fn, polohovací zařízení - miniaturní trackball se dvěma tlačítky, touchpad, Zobrazovací jednotka - 1/2 - 1/3 ceny, dříve 16 - 256 odstínů šedi, dnes 256 - 65 000 barev, pasivní displeje - záleží na úhlu pohledu x aktivní (TFT) displeje - vyšší světelnost, spotřeba, cena, nižší únava očí PDA - PPC Palmtop PC HPC - Handheld PC, Palm OS, přístup ke kontaktům, slovníkům, databázím, tabulkám, emailům ..., nahrazeny tablety, smartphony TABLET - 60. léta - Dynamo, přelom století Microsoft Tablet PC - neúspěch - cena, problém s použitelností 2010 iPad - forma slate -virtuální ne integrovaná fyzická klávesnice 2011 -(Microsoft) TABLET PC - desktopové operační systémy - Windows (procesory Intel x86 - odtud Wintel), Linux Ubuntu, řízen stylusem (vyšší přesnost) x POST PC - Samsung Galaxy Tab, Apple iPad - warm boot times Hardware pro rozpoznávání dotyku: Odprová (Rezistivní) obrazovka - pasivní, 2 tenké vodivé vrstvy - stlačení => pár napěťových děličů - změna el. Proudu - posláno řadiči Kapacitní dotyková obrazovka - panel potažen transparentním vodičem (ITO - slitina oxidu inditého a cíničitého) - dotyk prstu => vznik elektrostatického pole - to je měřitelné jako změna kapacitního odporu, vyžaduje vodivý materiál
CTFO-CELLUVie® -Collagen is a naturally occurring protein that supports healthy skin, bones, muscles, tendons, and overall health. Up to 30% of all the proteins in your body consists of collagen, which can be found in your skin, bones, muscles, tendons, blood vessels, and digestive system.Collagen is located in the skin, bones, cartilage, and other connective tissue of animals, such as fish, chickens, and cattle. And to get the five types you need – through food – would require you eating a lot of these various parts from a range of different sources. That's because no single source provides you all the different collagen types.Research shows you can increase your body's collagen levels again by consuming more collagen in your diet! That's true regardless of age, and that means – in terms of skin, hair, nails, joints, and more – you really can renew and revitalize the way you look and feel and once again enjoy the benefits of healthy collagen levels.Hydrolyzed Type I and III Collagen Your body normally produces its own supply of collagen. However, as you age, your body’s collagen production slows down significantly, leaving you with sagging skin, wrinkles, and other signs of aging. Fortunately, you can now boost your body’s natural levels of collagen with Groovy Bee Collagen Peptides. We have not offered collagen until now because clean sources were difficult to find and verify. Through extensive laboratory testing for glyphosate, heavy metals, microbiology and more, we have finally been able to procure and verify a supply line of clean collagen that contains no detectable levels of glyphosate or AMPA, a glyphosate byproduct. Derived from grass-fed cows, our non-GMO bovine collagen powder delivers Type I and Type III collagen that have been hydrolyzed for easier digestion and absorption. This nutritive supplement naturally contains protein, calcium, iron, and several amino acids. Groovy Bee Collagen Peptides is also meticulously lab tested for glyphosate, AMPA, microbiology, and heavy metals.What are collagen peptides and how can they benefit your body? Collagen peptides are bioavailable forms of collagen produced via hydrolysis. This process breaks collagen down into smaller, more easily digestible pieces without diminishing its nutritional content. When you consume collagen peptides, your body can easily use them as building blocks to rejuvenate your tissues. Scientists have identified at least 28 different types of collagen, but among the most important ones are Types I and III. Type I collagen consists of fibers that make up your skin, tendons, bones, ligaments, and other body parts. This type of collagen contains 19 amino acids, including alanine, proline, hydroxyproline, and glycine. Considered the strongest type of collagen, Type I collagen is responsible for healthy skin function and much more. Type III collagen is a fibrillary collagen that supports healthy hair, nails, skin, and bones. As the second most abundant type of collagen in your body, Type III collagen can mostly be found in your skin, lungs, intestines, vascular system, and other connective tissues. It plays an important role in supporting healthy organs and tissue. Groovy Bee Collagen Peptides contains hydrolyzed Type I and Type III collagen, both of which support healthy skin, bones, muscles, joints, tendons, and other organs. Support optimal health with the power of collagen peptides Health benefits of CCLLAGEN PEPTIDES* https://bhsales.myctfo.com/product_details.html?productcode=celluvie3pk https://bhsales.myctfo.com/shop.html?catekey=celluvieanddermavie https://bhsales.myctfo.com/vie.html --- Send in a voice message: https://anchor.fm/bhsales/message
The search term collagen has increased 40% already just in this year alone! So, is all the hype trendy or true? We’ve done the research and that’s the question we answer this week! Did you know that your body naturally produces collagen every day? We dig into why supplementation is even a consideration. Did you know there are several different types of collagen? We’ve tracked them all down and explain the part each type plays in our body. Is collagen all about less sagging skin? Actually, no it isn’t! Tune in to hear about the ways collagen benefits our health. We guarantee some will surprise you. Tune in for more no-nonsense information on what collagens are, how they may benefit your health, and what you need to look for when it comes to the products and foods, you're consuming. Dictionary result for collagen /ˈkäləjən/ noun the main structural protein found in skin and other connective tissues, widely used in purified form for cosmetic surgical treatments. "vitamin C plays a vital role in the formation of collagen" Different collagen molecules make up about ⅓ of the total protein in a human body Found in bone, skin, muscles, and tendons The substance that connects cells and gives skin elasticity as well as strength Collagen and Aging Your body naturally produces collagen every day. After the age of 25, we break down more collagen than we make. Collagen supplements are an easy way to add more collagen to your diet. Collagen has been shown to reduce wrinkles, keep joints strong and flexible, support strong bones, and increase skin hydration. Why is collagen so good for you? Collagen is vital for maintaining the structure and integrity of your entire body. #1 – Strong Cartilage and Muscles Cartilage is a type of connective tissue that is made up of collagen When you lack collagen, joint instability, stiffness, and pain can result. Likewise, muscles need cartilage to adhere themselves to the ends of bones. This is why muscle aches are one of the most common complaints of individuals with low collagen levels. #2 – Healthy Teeth. Collagen is needed to keep teeth in place in the gums. Loose teeth, toothache, sensitive teeth, and even tooth loss can result from a lack of collagen overall. #3 – Thick Hair Collagen plays an important part in hair growth since it fills in the spaces around each hair follicle. One way to tell if you are collagen deficient is to notice the quality and state of your hair. Dull, thin hair is a sign of low collagen levels. Collagen also helps fight free radicals that can damage hair. #4 – Smooth Skin Wrinkling and cellulite are other unfortunate results of low collagen in the body. Not enough collagen means skin begins to lose elasticity and sag, causing those pesky wrinkles as we age. Cellulite is another telltale sign of low collagen. #5 – Good Gut Health. Collagen helps heal the gut because of its ability to “seal the gut.” Leaky gut has been linked to autoimmune conditions and neurological conditions like autism. Types of Collagens There are over two dozen kinds of collagen, although roughly 85% of the collagen in the body is made up of Type I, II, or III (or a combination of these three types). Type I collagen is the most prevalent type of collagen. It is the substance that makes up the skin, tendons, and bones as well as the structural framework of the organs. It should be your go-to for hair, skin, and nail health, especially for recouping lost collagen stores that occurs naturally as we age. It is also a “well-rounded generalist,” in that it is a good type for supporting overall health. Type I is also found in the digestive tract, which makes it (along with Type II) great for gut healing and repair. Type II collagen is the structural component of cartilage in the body. Because of this, it is great for the joints and to rebuild cartilage in ligaments, tendons, skin, and bones. Type II collagen contains a variety of specific amino acids that are particularly helpful for the body. The first one, again, is glycine, which is beneficial for brain health and metabolism. The second one is proline, which helps clean artery walls. Type II may also be good for the respiratory system, detoxification pathways, and more because it contains arginine, another amino acid that is vital for nitric oxide production. [Note: Nitric oxide is produced in the body and is beneficial for supporting blood flow and lowering blood pressure.] For the most part, Type II collagen is where you want to turn for joint health and possibly even for arthritis support. Type III collagen is typically found where ever Type 1 collagen can be found as well as some other unique places. It is housed in what are called reticular fibers, the substances that make up connective tissue. It is also found in the muscles, bone marrow, blood vessels, and reproductive organs such as the uterus. Type III collagen is also crucial for the healthy functioning of the cardiovascular system. Low Type III collagen has been linked to ruptured blood vessels and can be life-threatening. Type IV collagen helps to strengthen endothelial cells that form the tissue protecting organs as well as muscles and fatty tissue. Endothelial cells also line the majority of the surfaces along the digestive tract and respiratory organs. Type V collagen helps create the surface of cells while Type X helps with bone formation. There are at least a dozen others, all doing their job to keep your body lubricated, moving, and functioning at its best. How to Help Your Body Create Collagen Naturally Eat a diet and live a lifestyle that promotes the healthy synthesizing of your own natural healing and repair mechanisms Avoid UV radiation exposure Do not smoke cigarettes Reduce/Manage stress levels What To Look For In A Collagen Supplement Look for multiple types of collagens Clean sourced and organic Bio-Availability - what is the delivery system - fermented, sprouted Whole food and not synthetic ingredients Contains Vitamin C - Without adequate amounts of dietary vitamin C, the body can’t actually form or store collagen Be sure the manufacturer does consistent batch testing for heavy metals Watch out for Natural Flavoring Ingredient List for Organixx Clean Sourced Collagens, Multi-Collagen Blend: Hydrolyzed Grass Fed Pasture-Raised Bovine Collagen Peptides, Bovine Bone Broth Hydrolyzed Protein, Chicken Bone Broth Collagen Concentrate, Clean Marine® Wild Caught Hydrolyzed Fish Collagen Peptides, Eggshell Membrane Collagen, Acerola Cherry (natural source of Vitamin C), Camu Camu (natural source of Vitamin C), Silica from Organic Horsetail, Zinc Gluconate, Fulvic Acid, and Pyroxidine Hydrochloride (Vitamin B6). Natural Flavors - Buyer Beware Important to note, a governmental or independent agency does not approve or oversee the safety of the food flavors. Deeper Dive Resources INSPIRED Library: All Collagen articles and recipes: https://organixx.com/?s=collagen&selector=art https://organixx.com/what-is-collagen/ https://organixx.com/benefits-of-collagen/ https://organixx.com/collagen-benefits/ https://organixx.com/types-of-collagen/ https://organixx.com/collagen-gut-health/ https://organixx.com/benefits-of-zinc-collagen/ https://organixx.com/collagen-for-hair/ https://organixx.com/vitamin-c-collagen/ https://organixx.com/collagen-for-joints/ https://organixx.com/collagen-skin-health/ Food Babe - Vani Hari https://foodbabe.com/the-differences-between-artificial-flavors-natural-flavors-organic-flavors-and-other-added-flavors/ The “Natural” vs. “Natural Flavors” Conflict in Food Labeling: A Regulatory Viewpoint. https://www.ncbi.nlm.nih.gov/pubmed/29140655 Studies: A randomized, double-blind, multicenter, controlled clinical trial of chicken type II collagen in patients with rheumatoid arthritis.- To assess the efficacy and safety of chicken type II collagen (CCII) in rheumatoid arthritis (RA) compared with methotrexate (MTX). CONCLUSION: CCII is effective in the treatment of RA. CCII is well tolerated, and the incidence of adverse events of CCII is lower than that of MTX. https://www.ncbi.nlm.nih.gov/pubmed/18576295 Effect of Orally Administered Collagen Peptides from Bovine Bone on Skin Aging in Chronologically Aged Mice - In summary, the present study demonstrated oral administration of collagen peptides from bovine bone could improve the laxity of chronologically aged skin by increasing skin collagen content and ratio of type I to type III collagen, but it had no effect on moisture retention of skin. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707681/ An Overview of the Beneficial Effects of Hydrolysed Collagen as a Nutraceutical on Skin Properties: Scientific Background and Clinical Studies - Skin, the main barrier to the external environment, is subject to deterioration caused by dermatological disorders, environmental conditions and the intrinsic ageing process. This damage to both structure and function may be accelerated by smoking, alcohol consumption and chronic sun exposure (extrinsic components). All these factors may lead to the formation of wrinkles, the appearance of brown spots and skin thickening. One effective strategy to managing the skin ageing process is adopting a healthy nutritional approach to life, maintaining a balanced diet and a good supply of food supplements. This can restore the homeostasis of macro and micronutrients and support the physiology of cells and tissues in the skin. Hydrolysed collagen, an increasingly popular nutraceutical, is composed of low molecular weight small peptides, which are easily digestible, absorbed and distributed in the human body. Numerous clinical trials have now been performed showing the efficacy and benefits of collagen peptides on skin properties, such as hydration, elasticity and reduction of wrinkles. As a result, hydrolysed collagen can be considered an important weapon in the everyday fight against skin ageing. https://benthamopen.com/ABSTRACT/TONUTRAJ-8-29 Dietary Supplementation with Specific Collagen Peptides Has a Body Mass Index-Dependent Beneficial Effect on Cellulite Morphology - The results obtained in this study demonstrated that an oral supplementation with specific BCP over a period of 6 months led to a clear improvement of the skin appearance in women suffering from moderate cellulite. In addition, the data showed the marked potential of BCP to improve the skin morphology of cellulite-affected areas, providing new evidence of BCP's beneficial effects and postulating a new therapy strategy for cellulite treatment. https://www.liebertpub.com/doi/full/10.1089/jmf.2015.0022 24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain. - The results of this study have implications for the use of collagen hydrolysate to support joint health and possibly reduce the risk of joint deterioration in a high-risk group. https://www.ncbi.nlm.nih.gov/pubmed/18416885
The search term collagen has increased 40% already just in this year alone! So, is all the hype trendy or true? We’ve done the research and that’s the question we answer this week! Did you know that your body naturally produces collagen every day? We dig into why supplementation is even a consideration. Did you know there are several different types of collagen? We’ve tracked them all down and explain the part each type plays in our body. Is collagen all about less sagging skin? Actually, no it isn’t! Tune in to hear about the ways collagen benefits our health. We guarantee some will surprise you. Tune in for more no-nonsense information on what collagens are, how they may benefit your health, and what you need to look for when it comes to the products and foods, you're consuming. What is collagen? Dictionary result for collagen /ˈkäləjən/ noun the main structural protein found in skin and other connective tissues, widely used in purified form for cosmetic surgical treatments. "vitamin C plays a vital role in the formation of collagen" Different collagen molecules make up about ⅓ of the total protein in a human body Found in bone, skin, muscles, and tendons The substance that connects cells and gives skin elasticity as well as strength Collagen and Aging Your body naturally produces collagen every day. After the age of 25, we break down more collagen than we make. Collagen supplements are an easy way to add more collagen to your diet. Collagen has been shown to reduce wrinkles, keep joints strong and flexible, support strong bones, and increase skin hydration. Why is collagen so good for you? Collagen is vital for maintaining the structure and integrity of your entire body. #1 – Strong Cartilage and Muscles Cartilage is a type of connective tissue that is made up of collagen When you lack collagen, joint instability, stiffness, and pain can result. Likewise, muscles need cartilage to adhere themselves to the ends of bones. This is why muscle aches are one of the most common complaints of individuals with low collagen levels. #2 – Healthy Teeth. Collagen is needed to keep teeth in place in the gums. Loose teeth, toothache, sensitive teeth, and even tooth loss can result from a lack of collagen overall. #3 – Thick Hair Collagen plays an important part in hair growth since it fills in the spaces around each hair follicle. One way to tell if you are collagen deficient is to notice the quality and state of your hair. Dull, thin hair is a sign of low collagen levels. Collagen also helps fight free radicals that can damage hair. #4 – Smooth Skin Wrinkling and cellulite are other unfortunate results of low collagen in the body. Not enough collagen means skin begins to lose elasticity and sag, causing those pesky wrinkles as we age. Cellulite is another telltale sign of low collagen. #5 – Good Gut Health. Collagen helps heal the gut because of its ability to “seal the gut.” Leaky gut has been linked to autoimmune conditions and neurological conditions like autism. Types of Collagens There are over two dozen kinds of collagen, although roughly 85% of the collagen in the body is made up of Type I, II, or III (or a combination of these three types). Type I collagen is the most prevalent type of collagen. It is the substance that makes up the skin, tendons, and bones as well as the structural framework of the organs. It should be your go-to for hair, skin, and nail health, especially for recouping lost collagen stores that occurs naturally as we age. It is also a “well-rounded generalist,” in that it is a good type for supporting overall health. Type I is also found in the digestive tract, which makes it (along with Type II) great for gut healing and repair. Type II collagen is the structural component of cartilage in the body. Because of this, it is great for the joints and to rebuild cartilage in ligaments, tendons, skin, and bones. Type II collagen contains a variety of specific amino acids that are particularly helpful for the body. The first one, again, is glycine, which is beneficial for brain health and metabolism. The second one is proline, which helps clean artery walls. Type II may also be good for the respiratory system, detoxification pathways, and more because it contains arginine, another amino acid that is vital for nitric oxide production. [Note: Nitric oxide is produced in the body and is beneficial for supporting blood flow and lowering blood pressure.] For the most part, Type II collagen is where you want to turn for joint health and possibly even for arthritis support. Type III collagen is typically found where ever Type 1 collagen can be found as well as some other unique places. It is housed in what are called reticular fibers, the substances that make up connective tissue. It is also found in the muscles, bone marrow, blood vessels, and reproductive organs such as the uterus. Type III collagen is also crucial for the healthy functioning of the cardiovascular system. Low Type III collagen has been linked to ruptured blood vessels and can be life-threatening. Type IV collagen helps to strengthen endothelial cells that form the tissue protecting organs as well as muscles and fatty tissue. Endothelial cells also line the majority of the surfaces along the digestive tract and respiratory organs. Type V collagen helps create the surface of cells while Type X helps with bone formation. There are at least a dozen others, all doing their job to keep your body lubricated, moving, and functioning at its best. How to Help Your Body Create Collagen Naturally Eat a diet and live a lifestyle that promotes the healthy synthesizing of your own natural healing and repair mechanisms Avoid UV radiation exposure Do not smoke cigarettes Reduce/Manage stress levels What To Look For In A Collagen Supplement Look for multiple types of collagens Clean sourced and organic Bio-Availability - what is the delivery system - fermented, sprouted Whole food and not synthetic ingredients Contains Vitamin C - Without adequate amounts of dietary vitamin C, the body can’t actually form or store collagen Be sure the manufacturer does consistent batch testing for heavy metals Watch out for Natural Flavoring Ingredient List for Organixx Clean Sourced Collagens, Multi-Collagen Blend: Hydrolyzed Grass Fed Pasture-Raised Bovine Collagen Peptides, Bovine Bone Broth Hydrolyzed Protein, Chicken Bone Broth Collagen Concentrate, Clean Marine® Wild Caught Hydrolyzed Fish Collagen Peptides, Eggshell Membrane Collagen, Acerola Cherry (natural source of Vitamin C), Camu Camu (natural source of Vitamin C), Silica from Organic Horsetail, Zinc Gluconate, Fulvic Acid, and Pyroxidine Hydrochloride (Vitamin B6). Natural Flavors - Buyer Beware Important to note, a governmental or independent agency does not approve or oversee the safety of the food flavors. Deeper Dive Resources INSPIRED Library: All Collagen articles and recipes: https://organixx.com/?s=collagen&selector=art https://organixx.com/what-is-collagen/ https://organixx.com/benefits-of-collagen/ https://organixx.com/collagen-benefits/ https://organixx.com/types-of-collagen/ https://organixx.com/collagen-gut-health/ https://organixx.com/benefits-of-zinc-collagen/ https://organixx.com/collagen-for-hair/ https://organixx.com/vitamin-c-collagen/ https://organixx.com/collagen-for-joints/ https://organixx.com/collagen-skin-health/ Food Babe - Vani Hari https://foodbabe.com/the-differences-between-artificial-flavors-natural-flavors-organic-flavors-and-other-added-flavors/ The “Natural” vs. “Natural Flavors” Conflict in Food Labeling: A Regulatory Viewpoint. https://www.ncbi.nlm.nih.gov/pubmed/29140655 Studies: A randomized, double-blind, multicenter, controlled clinical trial of chicken type II collagen in patients with rheumatoid arthritis.- To assess the efficacy and safety of chicken type II collagen (CCII) in rheumatoid arthritis (RA) compared with methotrexate (MTX). CONCLUSION: CCII is effective in the treatment of RA. CCII is well tolerated, and the incidence of adverse events of CCII is lower than that of MTX. https://www.ncbi.nlm.nih.gov/pubmed/18576295 Effect of Orally Administered Collagen Peptides from Bovine Bone on Skin Aging in Chronologically Aged Mice - In summary, the present study demonstrated oral administration of collagen peptides from bovine bone could improve the laxity of chronologically aged skin by increasing skin collagen content and ratio of type I to type III collagen, but it had no effect on moisture retention of skin. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707681/ An Overview of the Beneficial Effects of Hydrolysed Collagen as a Nutraceutical on Skin Properties: Scientific Background and Clinical Studies - Skin, the main barrier to the external environment, is subject to deterioration caused by dermatological disorders, environmental conditions and the intrinsic ageing process. This damage to both structure and function may be accelerated by smoking, alcohol consumption and chronic sun exposure (extrinsic components). All these factors may lead to the formation of wrinkles, the appearance of brown spots and skin thickening. One effective strategy to managing the skin ageing process is adopting a healthy nutritional approach to life, maintaining a balanced diet and a good supply of food supplements. This can restore the homeostasis of macro and micronutrients and support the physiology of cells and tissues in the skin. Hydrolysed collagen, an increasingly popular nutraceutical, is composed of low molecular weight small peptides, which are easily digestible, absorbed and distributed in the human body. Numerous clinical trials have now been performed showing the efficacy and benefits of collagen peptides on skin properties, such as hydration, elasticity and reduction of wrinkles. As a result, hydrolysed collagen can be considered an important weapon in the everyday fight against skin ageing. https://benthamopen.com/ABSTRACT/TONUTRAJ-8-29 Dietary Supplementation with Specific Collagen Peptides Has a Body Mass Index-Dependent Beneficial Effect on Cellulite Morphology - The results obtained in this study demonstrated that an oral supplementation with specific BCP over a period of 6 months led to a clear improvement of the skin appearance in women suffering from moderate cellulite. In addition, the data showed the marked potential of BCP to improve the skin morphology of cellulite-affected areas, providing new evidence of BCP's beneficial effects and postulating a new therapy strategy for cellulite treatment. https://www.liebertpub.com/doi/full/10.1089/jmf.2015.0022 24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain. - The results of this study have implications for the use of collagen hydrolysate to support joint health and possibly reduce the risk of joint deterioration in a high-risk group. https://www.ncbi.nlm.nih.gov/pubmed/18416885
In this podcast, Dr. Alex Bondoc and Dr. Rae Hanke discuss the intricacies of choledochal cysts. Contributing editor: Dr. Rod Gerardo. 00:00 | Introduction 00:26 | Definition of Choledochal cyst 00:36 | Epidemiology 01:06 | Etiology 02:00 | Todani Classification 03:20 | Presentation 05:08 | Differential diagnosis 05:42 | Workup 07:54 | Why only surgical treatment options? 09:18 | When to operate 10:12 | Preoperative evaluation 11:10 | Surgical goals of care 13:17 | Surgical technique 16:42 | Type II cyst 17:40 | Type III cyst 18:43 | Post operative care 20:29 | Key clinical takeaways Intro and outro tracks are adapted from "I dunno" by grapes, featuring J Lang, Morusque. Artist URL: ccmixter.org/files/grapes/16626
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.09.22.308627v1?rss=1 Authors: Muthuramalingam, M., Whittier, S., Lovell, S., Battaile, K. P., Tachiyama, S., Johnson, D. K., Picking, W. L., Picking, W. D. Abstract: Many Gram-negative bacterial pathogens use type III secretion systems (T3SS) to inject effector proteins into eukaryotic cells to subvert normal cellular functions. The T3SS apparatus (injectisome) shares a common overall architecture in all systems studied thus far, comprising three major components - the cytoplasmic sorting platform, the envelope-spanning basal body and the external needle with controlling tip complex. The sorting platform consists of an ATPase (SctN) connected to "pods" (SctQ) having six-fold symmetry via radial spokes (SctL). These pods interface with the 24-fold symmetric SctD inner membrane ring (IR) via an adaptor protein (SctK). Here we report the first high-resolution structure of a SctK protein family member, PscK from Pseudomonas aeruginosa, as well as the structure of its interacting partner, the cytoplasmic domain of PscD (SctD). The cytoplasmic domain of PscD forms a forkhead-associated (FHA) fold, like that of its homologues from other T3SS. PscK, on the other hand, forms a helix-rich structure that does not resemble any known protein fold. Based on these structural findings, we present the first model for an interaction between proteins from the sorting platform and the IR. We also test the importance of the PscD residues predicted to mediate this electrostatic interaction using a two- hybrid analysis. The functional need for Arg96 in vivo was then confirmed by monitoring secretion of the effector ExoU. These structures will contribute to the development of atomic-resolution models of the entire sorting platform and to our understanding of the mechanistic interface between the sorting platform and the basal body of the injectisome. Copy rights belong to original authors. Visit the link for more info
In today's VETgirl online veterinary continuing education podcast, we review Patent Ductus Arteriosus (PDA) in German Shepherd Dogs (GSD). While this isn't a common problem, GSDs seem to be over-represented. When diagnosing a PDA, it's important that a board-certified veterinary cardiologist perform appropriate diagnostic work up (e.g., echocardiography). Angiographic classification of patent ductus arteriosus (PDA) based on anatomical characteristics is important to determine treatment options. Traditional variations of a conical-shaped PDA (described as types I, IIa, and IIb) allow for successful closure via catheter-based transvascular techniques, whereby a device (such as the Amplatz canine ductal occluder, or ACDO) is used to occlude/embolize the PDA through arterial or venous access. Recently, type IV (multiple narrowings) and type V (all other variations) have been added to the list of anatomical classifications. Type III designation has classically been used to describe a tubular-shaped PDA which does not taper at the distal end (pulmonary artery side) and is not generally amenable to minimally-invasive interventional procedures due to high likelihood of device dislodgement. Closure of type III PDAs is generally performed by direct surgical ligation via thoracotomy as a result.
In today's VETgirl online veterinary continuing education podcast, we review Patent Ductus Arteriosus (PDA) in German Shepherd Dogs (GSD). While this isn't a common problem, GSDs seem to be over-represented. When diagnosing a PDA, it's important that a board-certified veterinary cardiologist perform appropriate diagnostic work up (e.g., echocardiography). Angiographic classification of patent ductus arteriosus (PDA) based on anatomical characteristics is important to determine treatment options. Traditional variations of a conical-shaped PDA (described as types I, IIa, and IIb) allow for successful closure via catheter-based transvascular techniques, whereby a device (such as the Amplatz canine ductal occluder, or ACDO) is used to occlude/embolize the PDA through arterial or venous access. Recently, type IV (multiple narrowings) and type V (all other variations) have been added to the list of anatomical classifications. Type III designation has classically been used to describe a tubular-shaped PDA which does not taper at the distal end (pulmonary artery side) and is not generally amenable to minimally-invasive interventional procedures due to high likelihood of device dislodgement. Closure of type III PDAs is generally performed by direct surgical ligation via thoracotomy as a result.
Health Ranger-Give your body a boost with Collagen Peptides and OptiMSM As you age, your body will need some support to maintain peak physical condition. Aside from regular exercise, maintaining your optimal health and well-being over the years requires an adequate intake of the right supportive nutrients. However, acquiring these vital nutrients is becoming harder than ever before due to the depletion of minerals in our food. That’s why the Health Ranger Store is bringing back your favorite lab-verified supplements for healthy skin, joints and muscles. Chief Originals® OptiMSM Flakes and Capsules make it easy to give your body a boost of sulfur through pure dietary methylsulfonylmethane (MSM). Sulfur is an essential nutrient that acts as one of the body's crucial building blocks, especially when it comes to supporting healthy joints, bones and connective tissues. We’re also offering three different varieties of Groovy Bee® Collagen Peptides that are essential for supporting healthy skin, bones and muscles: Pure Hydrolyzed Type I and Type III Collagen, Collagen Peptides + MCT and Prebiotic Fiber - Unflavored and Collagen Peptides + MCT and Prebiotic Fiber - Chocolate. All these premium supplements are non-GMO and extensively lab tested for glyphosate, heavy metals and microbiology. Stock up on lab-verified supplements for optimal health! Get ultra-clean, lab-verified collagen peptides today! Collagen is a naturally occurring protein that supports healthy skin, bones, muscles, tendons and overall health. Collagen peptides are a highly bioavailable form of collagen produced via hydrolysis. This process breaks collagen down into smaller, more easily digestible pieces without diminishing its nutrient content. Collagen consumed in this form can easily be used by the body as building blocks to naturally rejuvenate aging tissue. The most abundant types of collagen in your body are Type I and Type III collagen. Clean sources of collagen peptides are often difficult to find and verify, but through extensive laboratory testing for glyphosate, heavy metals, microbiology and more, we are able to bring you ultra-clean, lab-verified Groovy Bee® Collagen Peptides derived from grass-fed cows. They have also been hydrolyzed for easier digestion and absorption. GROOVY BEE® COLLAGEN PEPTIDES https://bhsales.vpweb.com --- Send in a voice message: https://anchor.fm/bhsales/message Support this podcast: https://anchor.fm/bhsales/support
Dr. Shalin Shah discusses his perspectives on the patient experience, orthodontic evolution, education, and life philosophies. Dr. Shah maintains two active orthodontic practices in Princeton Junction, NJ and Lawrenceville, PA (Center for Orthodontic Excellence) and was previously serving as a Clinical Associate in the Department of Orthodontics at the University of Pennsylvania for nine years. He received his BA, DMD, Certificate in Orthodontics, and Masters of Science in Oral Biology from the University of Pennsylvania. Dr. Shah is a Diplomate of the American Board of Orthodontics and member of the AAO, ADA, American Cleft Palate and Craniofacial Association, and SCADA among other notable professional organizations. At the University of Pennsylvania, he has lectured on orthodontic records, space analyses, cephalometrics, career development, growth & development, biology of the temporomandibular joint (TMJ), occlusal appliances, practice management, and preventive & interceptive orthodontics as well as various other topics. He also provides didactic and clinical instruction for pre-doctoral students and orthodontic residents. Dr. Shah has received awards for Excellence Clinical Education (2014) and Excellence in Didactic Education (2016) from the University of Pennsylvania. Dr. Shah's research interests primarily include the biological sensitivity of the TMJ. He has conducted novel research on Type III collagen-deficient mice looking at their skeletal development and maintenance, including effects on the TMJ. He is published in various dental and orthodontic peer-reviewed journals. Additionally, he has received several research awards, most notably the 2004 Vernon J. Brightman Research Society Award from the University of Pennsylvania, the 2004 ADA/Dentsply Student Clinician Research Award, the 2006 Quintessence Award for Research Achievement from the University of Pennsylvania, the 2006 Drabkin Memorial Prize for Research in Biochemistry from the University of Pennsylvania, the 2009 Musculoskeletal Disorders Annual Scientific Symposium Poster Award from the University of Pennsylvania, the 2010 Charley Schultz Resident Scholars Award from the American Association of Orthodontists, and the 2010 William S. Kress Award from the Mid-Atlantic Society of Orthodontists. Dr. Shah also maintains a keen interest in the digital workflow, which includes digital scanners, aligner therapy, and 3-D printing. He has comprehensively evaluated orthodontic products and services within these spaces with an intention of improving the user experience while also bringing together current-day CBCT diagnosis to today's aligner treatment. Dr. Shah looks to change the orthodontic practice experience while maximizing the patient treatment outcomes. His passion for research, clinical orthodontics, excellence in patient care, and commitment to education has made him a solicited lecturer at a national and international level. The full liability release statement for the Dental Clinical Companion Podcast is in force. To view the full statement, go to http://www.dentalclinicalcompanion.com/. Support the show (http://mounceendo.com/)
When Rebecca Alexander was 12 years old, she had trouble seeing the blackboard. She made her way from an optometrist to an ophthalmologist and was eventually diagnosed with Retinitis Pigmentosa (RP). Her parents were told that she would be blind by the time she was an adult. Rebecca also had a cookie bite of hearing loss. Through high school, she wore her hearing aids as little and as discreetly as possible. It wasn’t until Rebecca was in college that she experienced extreme tinnitus and saw an otolaryngologist that the diagnosis of Usher syndrome became real. Today, Rebecca Alexander is an award-winning author, psychotherapist, keynote speaker, group fitness instructor, disability advocate, and extreme athlete. She also has Usher syndrome type III, and is almost completely blind and deaf. Her book, Not Fade Away: A Memoir of Senses Lost and Found is being made into a major motion picture. GAP licensed a mantra from her memoir, “Breathe in Peace, Breathe out Fear,” and launched a campaign on International Women’s Day in March 2020, featuring Rebecca as well as another woman with Usher syndrome. The two t-shirts that GAP created have already sold out, but you can see the campaign video here! Have thoughts or a related story you’d like to share? Leave us a short voice message here! We may use your message on a future show. Rebecca Alexander’s website Buy Rebecca's book: Not Fade Away: A Memoir of Senses Lost and Found Connect with Rebecca on Social Media: Rebecca on Twitter: @Reb_Alexander Rebecca on Instagram: @reb_alexander Rebecca on Facebook Resources related to Usher syndrome Usher Syndrome Coalition Usher Syndrome Society Ava’s voice (in NJ) The Foundation Fighting Blindness The Hellen Keller National Center Check out other Patient Stories podcast episodes. Do you want to support Patient Stories? You can now make a donation online! Want to support Patient Stories in a non-monetary way? Leave us a review on iTunes, or share your favorite episodes on Social Media. Patient Stories on Twitter: @GreyGeneticsPod Patient Stories on Instagram: @patientstoriespodcast Are you looking for genetic counseling? Patient Stories is sponsored by Grey Genetics, an independent telehealth genetic counseling and consulting company. Book an appointment with a genetic counselor specialized in your area of concern. All genetic counseling appointments take place over secure, HIPAA-compliant video-conferencing or by phone.
Headaches are a common complaint among patients with whiplash associated disorder (WAD) following a motor vehicle collision, slip and fall, or sports injury. While in some cases, the cause of WAD-associated headache can be a concussion or traumatic brain injury (TBI), in many instances the underlying cause of WAD-related headaches can be injury to the neck. How is this possible? Past research has demonstrated that irritation of the nerves that pass through the top of the cervical spine (C1, C2, and C3) can lead to tension-type or cervicogenic headaches, especially when the C2 nerve is involved. These nerves exit the spine and travel through a thick group of muscles located at the top of the neck/base of the skull or “suboccipital” region. In a 2019 study, a group of anatomists discovered the close relationship of the greater occipital nerve (C2) and a muscle called the obliquus capitus inferior (OCI) and sought to determine how the C2 might get “pinched” in injuries such as whiplash. The authors studied 20 cadavers and found three patterns. The nerves either travelled loosely around the muscle (Type I), were incorporated in the dense muscle fascia (Type II), or travelled directly through a myofascial sleeve within the muscle (Type III). Among the 40 C2 nerves (there is a left and right), the research team found seven instances of Type I, thirty-one instances of Type II, and two instances of Type III. Because of the intimate relationship between the OCI and C2 nerve, it's understandable that during the whiplash process, the stretching of C2 nerve combined with the contraction of the OCI could set the stage for injury to the nerve. Doctors of chiropractic frequently find that WAD patients have a great deal of tenderness in the suboccipital region and respond well to upper cervical spinal manipulation and mobilization. When these muscles are more relaxed, neck pain and headaches often improve. Similarly, exercises that focus specifically on this region help the patient self-manage headaches and neck pain, which reduces the need for medications, many of which have negative side-effects. One such exercise is called the cervical brace. This is done by kneeling on all fours and is broken down as follows: 1) “poke” your chin/head straight down toward the floor; 2) in a smooth scooping motion, tuck your chin down (chin-to-chest); 3) and then scoop your head back up to neutral keeping the chin tucked. Repeat in a smooth scooping motion (avoid doing it “steps”). Repeat until your neck feels loose. You may notice some painless popping, crunching sounds as you do the exercise. As modifiers, try it sitting or standing, with or without resistance applied to the forehead. Studies show neck pain and headaches arising from WAD injuries respond very quickly to chiropractic care. Please consider chiropractic care FIRST in your post-WAD management process! www.PainReliefChiroOnline.com
Ready For Takeoff - Turn Your Aviation Passion Into A Career
From Wikipedia: Deicing fluids come in a variety of types, and are typically composed of ethylene glycol (EG) or propylene glycol (PG), along with other ingredients such as thickening agents, surfactants (wetting agents), corrosion inhibitors, colors, and UV-sensitive dye. Propylene glycol-based fluid is more common due to the fact that it is less toxic than ethylene glycol. Type I fluids have a low viscosity, and are considered "unthickened". They provide only short term protection because they quickly flow off surfaces after use. They are typically sprayed on hot (130–180 °F, 55–80 °C) at high pressure to remove snow, ice, and frost. Usually they are dyed orange to aid in identification and application. Type II fluids are pseudoplastic, which means they contain a polymeric thickening agent to prevent their immediate flow off aircraft surfaces. Typically the fluid film will remain in place until the aircraft attains 100 knots (190 km/h) or so, at which point the viscosity breaks down due to shear stress. The high speeds required for viscosity breakdown means that this type of fluid is useful only for larger aircraft. The use of Type II fluids is diminishing in favor of Type IV. Type II fluids are generally clear in color. Type III fluids can be thought of as a compromise between Type I and Type II fluids. They are intended for use on slower aircraft, with a rotation speed of less than 100 knots. Type III fluids are generally bright yellow in color. Type IV fluids meet the same AMS standards as Type II fluids, but they provide a longer holdover time. They are typically dyed green to aid in the application of a consistent layer of fluid. From NASA: There are four standard aircraft de-icing and anti-icing fluid types: Type I, II, III, and IV. Type I fluids are the thinnest of fluids. As such, they can be used on any aircraft, as they shear/blow off even at low speeds. They also have the shortest hold-over times (HOT) or estimated times of protection in active frost or freezing precipitation. Type II and IV fluids add thickening agents to increase viscosity. The thickeners allow fluid to remain on the aircraft longer to absorb and melt the frost or freezing precipitation. This translates to longer HOT, but it also means a higher speed is required to shear off the fluid. Type III fluids are relatively new and have properties in between Type I and Type II/IV fluids. Type III fluids also contain thickening agents and offer longer HOTs than Type I, but are formulated to shear off at lower speeds. They are designed specifically for small commuter-type aircraft, but work as well for larger aircraft. *Note: Holdover Times (HOT) are published in a range to account for variations in precipitation intensity: shorter time for heavier intensity, longer time for lighter intensit Type I fluids are always applied heated and diluted. For de-icing, it is the heat and hydraulic force that accomplish the task. For anti-icing, it is primarily the heat imparted to the airframe that accomplishes the task. Caution: Type I fluids have the shortest HOT. When a Type I fluid fails, it fails suddenly. Type II and IV fluids may be applied heated or cold, and diluted or full strength. In North America, typically Type IV fluids are applied cold, and only for anti-icing. In the UK, typically Type II or IV fluids are applied heated to accomplish de-icing as well as anti-icing.
Scripture Reading- Exodus 14-Text- Exodus 14-21-31--Israel's Baptism in the Red Sea -Baptism--I. The Event-II. The Type-III. The Result
A lot of people will tell you cognitive decline is inevitable as you age - but is it really? Here to tell us how to fight cognitive decline through diet and technology is an extraordinary health coach duo: Patrick Coady and Silvana Spano. On today's Awesome Health podcast, they'll be sharing technology and nutritional protocols that can slow down or even reverse cognitive decline issues such as brain fog, memory loss, even dementia and Alzheimer's Disease. In this episode of Awesome Health, you'll also hear: What are the 5 areas of the body that must be balanced to achieve optimal health? What is Type III diabetes? What is the best intervention? Is cognitive decline reversible? And much more! More About Awesome Health with Patrick Coady and Silvana Spano Silvana Spano is a trained psychologist who specializes in holistic health; she has integrated her psychotherapy knowledge and physical health. She studies alternative ways of healing, and has apprenticed with indigenous Mayan healers. Patrick Coady is a naturopath with training in lifestyle changes, detoxes, cleanses and nutrition. They've been learning from the top people in the world, and have found the way to optimal health is through a holistic approach that allows the body to tap into its own innate healing abilities. My first question was to find out who is typically impacted by cognitive decline, and what those symptoms look like when they show up. They explain cognitive decline usually starts many years - even decades - before someone seeks help to treat it. It used to happen in people over 60, today they are seeing people as young as in their 30s with symptoms! They began specializing in this area when they moved to Ecuador about 7 years ago. They encountered a population of North American retirees in their area and a lot of cognitive decline issues were affecting these people. Their cognitive problems were only exacerbated by the higher elevation of the area they lived in. The higher the elevation the lower the oxygen levels and lower oxygen levels can make cognitive impairment symptoms worse than if they were at a lower elevation or at sea level. Some of the early stage symptoms Patrick and Silvana would see include forgetting small things like where they placed their keys, forgetting names, difficulty retrieving words they know, plus brain fog and sleep issues like insomnia and poor sleep quality. In fact, they've seen a lot of patients with years of sleep issues prior to being diagnosed with dementia and Alzheimer's disease. The Causes of Cognitive Decline With the increase of people experiencing cognitive decline, I asked them what the reasons are behind this increase. They gave the top two reasons: toxins and high glucose levels. Regarding toxins, we are all exposed to toxins regularly. The biggest culprits are mercury, aluminum, chemicals like bleach, herbicides, pesticides, fungicides and synthetic estrogens. High glucose levels are a problem because people with insulin-related diabetes have a much higher chance of having Alzheimer's or other forms of dementia. They are so related that today Alzheimer's has been commonly called Diabetes Type III. Patrick goes on to explain how inflammation leads to infections and how compromised gut health leads to more infections in our bodies, which in turn leads to more infections in our brains. Techniques For Healing Cognitive Decline But it isn't all dire news, Patrick and Silvana are exceptional at treating cognitive decline in their patients. Their first step when meeting with a new client is to find out if the new patients is truly ready to heal - or not. The patient has to be ready! Typically this person has tried conventional approaches and they haven't worked, or they are the type of person who is naturally inclined to use alternative healing options. If people aren't ready then Patrick and Silvana send those people on to their doctors. They themselves are not doctors, they are health coaches who are there to support and encourage people to take care of themselves. They are educators. When people are ready, Silvia explains they begin to work on the person's diet. The quality of their food is important, as is removing inflammatory foods from the diet. She and Patrick also work with the client to figure out what foods aren't good for that specific person. They do this through techniques like testing, or food journaling to find out how food affects each person. They also work with a patient to help them detoxify their body. They guide their client through basic ways of cleansing and detoxing. When the patient's health allows they move to deeper levels of detoxification. Intermittent fasting is a useful tool here. At this stage they also address the emotional, psychological and energetic aspects of detoxing in their bodies and in other areas of their life like relationships. 5 Surprising Inflammatory Foods Since they raised the topic of inflammatory foods, I also asked them to give us 5 surprising foods that are inflammatory. They gave us 5 inflammation-causing foods most of us aren't aware of including: 1. Beans and legumes. Some people react strong to these and that reaction can cause inflammation in the body and the brain. 2. Seeds. The same thing can happen here. Most people think seeds are healthy, but they are not for everyone so they have to work with their client to find out if seeds help or hurt their health. 3. Eggs. This is a common inflammatory food for a lot of their patients, Patrick explains they see a lot of their patients with antibodies to eggs and that means eggs have to be eliminated. 4. Grains. Surprisingly all of grains have been found to have gluten proteins and can cause inflammation. If someone isn't in good health removing all grains can be beneficial. 5. Grasses. This means all the grasses like alfalfa, and wheat grass. While those two foods are thought of as healthy, they can be inflammatory for some people. On this edition with Patrick Coady and Silvana Spano, you'll also find out if there is a link between psychological trauma and the onset of cognitive decline. Plus, Patrick shares the technological breakthroughs they use, including the next generation of light therapy advancements and the results they see in their patients. Join us for those topics and much more on today's episode of Awesome Health! Episode Resources Patrick Coady and Silvana Spano's web site Email Patrick and Silvana Vielight web site Masszymes web site (promo code shake10)
Episode 20 off 2019! This episode I invited from Portugal QUIZAK this young fella knows how to put things together! QUIZAK is a name derived from Kwisatz Haderach (Kwizatz) given to a fictional character representing a messianic figure in the 1984 cult classic science fiction movie Dune. It’s set in the distant future, a time c.20,000 years from the present day, where all thinking machines have been outlawed. Humans have become a Type III civilization able to travel throughout the galaxy by folding space. This is the theme underpinning QUIZAK’s approach as he blends nuanced techno elements with mastery of production to take you on an interstellar journey of epic proportions. Tracklist 01 Van der Meer - Thisbe 02 Inland - Swerv 03 Selection Natural - Random Mutations 04 Pussyshaver - Ps20 05 James Bong - Anrine 06 Prophn - Animalia 07 Kaiser - Solitude 08 Olexii - Blood Fatality 09 Oscar Mulero - Chasing Shadows 10 QUIZAK - Largo 11 Setaoc Mass - Psychofiller 12 Oscar Mulero - Metalix 13 Wrong Assessment - Eldritch 14 Van der Meer - Irenea 15 Setaoc Mass - Evidence 16 QUIZAK - Lares 17 Olexii - Eastland Acid 18 Sebastian Bayne - Interpolar 19 Inland - Time Leak Support him here https://soundcloud.com/quizakmusic https://www.facebook.com/QuizakMusic/?ref=br_rs See ya al next week for another episode! I'm NOT Normal every Saturday from 17h till 18h Central European Time on http://www.dancetunesradio.com/listen/
Cardiovascular risk is so high in type III hyperlipoproteinemia that is typically a “treat immediately on diagnosis” disorder. In the February 2019 issue of Clinical Chemistry, a paper presented the advantages of a non-high density lipoprotein cholesterol ratio with apolipoprotein B as a diagnostic tool for type III hyperlipoproteinemia. In the same issue, an accompanying editorial entitled “Type III Hyperlipoproteinemia: The Forgotten, Disregarded, Neglected, Overlooked, Ignored but Highly Atherogenic, and Highly Treatable Dyslipo-proteinemia” was also published. The author of that article is Dr. Allan Sniderman, the Edwards Professor of Cardiology at McGill University in Montreal, Quebec, Canada, and he is our guest in this podcast.
Switch the B.S. meter to the "on" position and listen to the wise and powerful Dr. Cate Shanahan address many myths and misconceptions about keto, and other ancestral health practices on this hard-hitting show. Brad has avoided caffeine his whole life so he won't "fry his adrenals." Dr. Cate calls BS. How about eating in the evening--makes you store fat, right? Probably doesn't matter that much. Can you generate ketones on a super high carb diet? Yes you actually can, says Cate. It's all about long periods of fasting or eating in a caloric deficit. Cate gives us some sneak previews from her fabulous new book, The Fat Burn Fix, that will land in 2020 (hold your breath until then, this is bound to be a masterpiece follow up to her landmark mega-bestseller Deep Nutrition. This book was originally self-published in 2009 and helped spur the explosive growth of the primal/paleo movement. In it, Dr. Catepresented her trademarked "Four Pillars of the Human Diet" Oh yeah, you know those headaches that happen during a busy, sugar crash burnout day? This pattern can become a serious matter whereby you suffer from frequent mini-strokes when your brain is deprived of oxygen due to overconsumption of carbs and the brains over-reliance on sugar. Prominent author Dr. David Perlmutter calls Alzheimer's “Type III diabetes” due to the close association between insulin resistance and cognitive decline. Good news shared by Dr. Cate is you can reverse early brain problems and stroke risk by transitioning to a more nutrient-dense, lower sugar, and especially keto-friendly diet. This is no funny business, as Dr. Cate offers the stat the typical western diet derives 66 percent of total calories from the big three main most offensive modern foods: sugars, grains, and refined vegetable oils. Dr. Cate is not afraid to call out entities like Harvard University for aggressively promoting nutrient-deficient diets for decades, spurred by corporate influences and the almighty dollar. This is highly disturbing, and greatly inspiring to take matters of health into your own hands.
Lucie, Niels und Martin philosophieren über das Bydo Empire und Vaginavulkane.
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Back in 2014 we did an interview with Tim Urban of WaitButWhy.com about the Fermi Paradox and it blew our minds. Now we're reaching into the archives, dusting off this interview and playing it today for our newer unbelievers. Is there life out there? With a universe so vast, Where is everybody? Is this even a real show? Follow along with the article from WAITBUTWHY.COM:http://waitbutwhy.com/2014/05/fermi-paradox.htmlThe Monsanto Interview To Mash-Up:https://www.youtube.com/watch?v=ovKw6YjqSfMAnswer this week's poll:http://www.unbelievablepodcast.com/post/145560155136/this-weeks-poll-are-we-alone-in-the-universe------------------The Unbelievable Podcast hosts today were Phoebe Tyers and me Brian Frange. Our Web Producer who runs the Facebook page is Dan Gascon, our Production Coordinator is Nikolas Eristavi, our Wiki Moderators are Michelle Durham and StarFoxMulder, our Larry Sinclair correspondent is Sharky Xmas, and our Senior Space Correspondent is SpaceChode. And this week's episode is brought to you by The Advanced Being Ant Hill Detector. Are you an advanced being who loves exploring the universe but is afraid of the destruction you may leave in your path? Well with our patented ant hill detector you'll be able to avoid crushing any inferior civilizations totally by accident. It's the Advanced Being Ant Hill Detector, just because you're a Type III civilization doesn't mean you have to be a Type II asshole. Beep Beep. You just killed a planet.
Medizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 18/19
Neuregulin-1 (NRG1) type III is a growth factor on the surface of neurons in the peripheral nervous system (PNS). It is required for initial myelination of nerves by Schwann cells after birth and for remyelination after injury. Neuregulin-1 type III is activated by cleavage (shedding) in its extracellular juxtamembrane region generating a membrane-bound N-terminal fragment (NTF) that contains a bioactive epidermal growth factor (EGF)-like domain. This domain signals to neighboring Schwann cells in a contact-dependent manner prompting the cells to initiate myelination. The β-site APP cleaving enzyme 1 (BACE1) was identified as the enzyme that cleaves NRG1 type III and promotes myelination. Consequently, loss of BACE1 cleavage results in dramatically reduced myelin sheaths around nerves in the PNS of BACE1 knockout mice. Besides its role in myelination, BACE1, better known as β-secretase, is also involved in the generation of the neurotoxic amyloid β-peptide (Aβ) which is the main component of amyloid plaques in the brain of patients suffering from Alzheimer’s disease (AD). The Aβ peptide is derived through sequential cleavage of the amyloid precursor protein APP, first by BACE1 in the extracellular domain and subsequently by the γ-secretase in the transmembrane domain (TMD). Inhibition of BACE1 and γ-secretase is therefore considered a promising therapeutic strategy for AD. However, this approach harbors the risk of mechanism-based side effects due to impaired processing of substrates beside APP such as NRG1 type III which is not only a substrate for BACE1 but like APP is also cleaved in its TMD by the γ-secretase. Adding another layer of complexity, ADAM10 and ADAM17, the so-called α-secretases of AD, also cleave NRG1 type III. In the first part of this study, the proteolytic processing of NRG1 type III in its ectodomain was investigated in detail. The precise juxtamembrane shedding sites of BACE1, ADAM10 and ADAM17 were determined by mass spectrometry and two novel cleavage sites of BACE1 and ADAM17 N-terminal of the EGF-like domain were discovered. Cleavage at these novel sites by ADAM17 and BACE1 results in the secretion of the EGF-like domain from NRG1 type III as α-sEGF and β-sEGF, respectively. Using novel monoclonal antibodies generated against the identified cleavage sites the processing of NRG1 type III could also be confirmed in primary neurons. The soluble EGF-like domains were found to be functionally active and induced signaling pathways required for myelination in cultured Schwann cells. Furthermore, β-sEGF rescued the myelination deficit in the PNS of a zebrafish model lacking BACE1, thereby demonstrating its activity in vivo. Using cell culture and the zebrafish model the effects of BACE1- and ADAM17-mediated shedding on the activity of the soluble EGF-like domains were carefully dissected. In contrast to published evidence, however, both the BACE1- as well as the ADAM17-shed sEGF were found to be equally active and to promote myelination in vivo. Together this suggests that NRG1 type III dependent myelination is not only controlled by membrane-retained NRG1 type III but also in a contact-independent manner via proteolytic liberation of the EGF-like domain. The second part of this study investigates the processing of the C-terminal fragment (CTF) which remains after shedding of NRG1 type III. Intramembranous cleavage of the CTF by the γ-secretase was previously shown to release the NRG1 intracellular domain, which acts as transcriptional regulator of proteins involved in neuronal maturation and brain plasticity. Interestingly, a mutation within the TMD of NRG1 type III is associated with an increased risk of schizophrenia linking γ-secretase processing of NRG1 type III to this neurological disorder. Using a novel antibody against the N-terminus of the NRG1 CTF it was possible to detect a NRG1 β-peptide that is secreted during γ-secretase cleavage and could potentially serve as marker for this processing. Moreover, by means of mass spectrometry, the precise cleavage sites within the TMD of NRG1 could be identified. Strikingly, the ɛ-like cleavage site was found to be located exactly at the position of the schizophrenia-associated mutation providing a possible mechanism for the reported interference of this mutation with γ-secretase cleavage. The evidence presented unambiguously establishes NRG1 type III as a γ-secretase substrate and provides a basis for further investigation of the mechanisms which link its processing to the development of schizophrenia. In summary and with regard to BACE1 and γ-secretase being prime targets for a potential AD therapy, the results of this work call for further careful investigation of the consequences of altered NRG1 type III signaling due to chronic treatment with inhibitors.
Background: Ralstonia solanacearum is a soil-borne beta-proteobacterium that causes bacterial wilt disease in many food crops and is a major problem for agriculture in intertropical regions. R. solanacearum is a heterogeneous species, both phenotypically and genetically, and is considered as a species complex. Pathogenicity of R. solanacearum relies on the Type III secretion system that injects Type III effector (T3E) proteins into plant cells. T3E collectively perturb host cell processes and modulate plant immunity to enable bacterial infection. Results: We provide the catalogue of T3E in the R. solanacearum species complex, as well as candidates in newly sequenced strains. 94 T3E orthologous groups were defined on phylogenetic bases and ordered using a uniform nomenclature. This curated T3E catalog is available on a public website and a bioinformatic pipeline has been designed to rapidly predict T3E genes in newly sequenced strains. Systematical analyses were performed to detect lateral T3E gene transfer events and identify T3E genes under positive selection. Our analyses also pinpoint the RipF translocon proteins as major discriminating determinants among the phylogenetic lineages. Conclusions: Establishment of T3E repertoires in strains representatives of the R. solanacearum biodiversity allowed determining a set of 22 T3E present in all the strains but provided no clues on host specificity determinants. The definition of a standardized nomenclature and the optimization of predictive tools will pave the way to understanding how variation of these repertoires is correlated to the diversification of this species complex and how they contribute to the different strain pathotypes.
Objectives: To determine the serum concentrations of procollagen type in peptide in severely injured patients with different outcomes and to evaluate the relationship between serum procollagen type III peptide concentrations, sources of increased posttraumatic fibrotic activity (wounds, lung, liver, kidney), and decreased elimination of procollagen type III peptide (liver). Design: Prospective study. Setting: Surgical ICU, university hospital. Patients: Fifty-seven patients (mean injury severity score: 38.5 points, range 13 to 75 points), between 16 and 70 yrs of age, treated in our institution within 6 hrs after the accident. Measurements: Serial measurements were started on admission and continued on a 6-hr basis. After 48 hrs, the monitoring interval was extended to 24 hrs until recovery (but at least until day 14) or death. At each point of evaluation, pulmonary and circulatory function parameters and chest radiographs (once a day) were evaluated, the results were recorded, and blood samples were drawn to determine procollagen type III peptide, total bilirubin, creatinine, [gamma]-glutamyl transferase, polymorphonuclear elastase, and other parameters. Statistic evaluation was done with the Wilcoxon test, Spearman rank correlation, and a multiple regression model. Results: Mean procollagen type m peptide serum concentrations (+/- sd) were significantly different in patients who died (8.0 +/- 3.8 U/mL) compared with those patients who survived with organ failure (2.7 +/- 1.3 U/mL) or without complications (1.4 +/- 0.5 U/mL), respectively. Significant correlations of procollagen type HI peptide concentrations with the serum bilirubin concentrations (r = .7), days with need of mechanical ventilation (r = .64), Pao2/Fio2 ratio (r = -.6), polymorphonuclear elastase (r = .6), serum creatinine concentrations (r = .55), and injury severity score (r = .33) were observed. There was a tendency toward higher serum procollagen type III peptide concentrations in patients with severe skeletal injuries. Conclusions: Serum procollagen type III peptide concentrations in severely injured patients may be considerably increased in correlation with injury severity and outcome. Procollagen type III peptide serum concentrations seem to reflect the sum of increased collagen formation from wound healing and fibrogenesis of mediator-related organ damage (especially lung) and decreased procollagen type HI peptide excretion due to impaired liver function. Further data are necessary to evaluate the role of hepatic elimination in these patients.
Fibronectin, collagen type III, laminin, and cytokeratin 5 were visualized in normal skin and in skin showing early or advanced signs of autolytic decomposition to prove whether the immunohistochemical analysis of these antigens can provide useful information for an age-estimation of skin wounds obtained from putrified corpses. In cases with early signs of decomposition (visible course of veins, greenish discoloration) and without microscopic alterations like relaxation of the epidermal cell layers or destruction of the blood vessel structures, the staining pattern was identical to that found in normal, non-putrefied skin. In skin already showing microscopic alteration of the tissue structure, fibronectin and collagen type III could not be localized unambiguously. The distribution of laminin and cytokeratin 5, however, was well preserved. In advanced putrefied skin no reliable staining results could be obtained for fibronectin, collagen type III, and laminin. Even though cytokeratin 5 was still detectable in remnants of decomposition-resistant skin appendages, no information useful for an age-estimation of skin wounds can be obtained due to the autolytic detachment of the epidermal layers.
In the present study, we have compared the staining pattern of the Solophenyl-Red 3 BL-method for the visualization of collagen type III with the immunohistochemical staining in serial sections from 7 skin wounds (wound age 3 days up to 4 weeks) to elucidate the specifity of the histochemical staining method. Large amounts of collagen type III were clearly detectable in the investigated wounds using the immunohistochemical technique. In the sections stained with Solophenyl-Red, however, only 3 out of 7 skin lesions showed a significant positive red staining at the wound margin or in the granulation tissue, while the adjacent normal connective tissue revealed a typical intensive staining. Using polarization microscopy no characteristic bright green fibrils, as reported for collagen type 111, could be seen in the wound areas without positive Solophenyl-Red staining. Since the localization of collagen type III detected by immunohistochemistry and the presumed distribution of this collagen type by the Solophenyl-Red method was not identical, the histochemical polarization method has to be regarded as non-specific for visualization of this collagen type.
In 38 traumatic knee joint effusions the proteolytic enzyme PMN-elastase (PMN-E) and the repair marker procollagen III aminoterminal peptide (PIIINP) were determined. According to the period between trauma and first aspiration of the effusion, the patients were divided into 3 groups. Group I (17 patients; period between trauma and first aspiration not longer than 72 hours) showed high concentrations of PMN-E (up to 5400 ng/ml) and low concentrations of PIIINP (
Enjoy my summary of Dr. Robert Lustig's excellent book, The Hacking Of The American Mind. Sir Roger Bannister said, “Struggle gives meaning and richness to life.” But what happens without struggle? In our world, our minds are constantly being hijacked by profit-seeking, corporate entities delivering instant pleasure at the expense of long-term happiness and contentment. Humans are hard-wired to respond to novel stimulation, and our modern, high-tech existence has left us addicted to instant gratification pleasures, at the expense of enjoying our lives. Companies know this well, so they prey on our need for instant gratification by satisfying that need, through the products they’re trying to sell. What you have to watch out for is overdoing things in pursuit of the next dopamine rush...because that is when it becomes actually destructive, and it diminishes our ability to feel happy and content with our lives. So, what exactly is capable of hacking our minds? Sugar, digital technology, caffeine, drugs (from street drugs to weed) as well as prescription drugs, like antidepressants and pain pills. When you indulge in any of these, you hack your dopamine pathway, *which is really like cheating your way to feeling better.* Obviously, while this may make you feel better in the moment, this only hurts you in the long run, because you’re putting a Band-Aid over a bullet hole. It’s like the acne drug, Accutane. Sure, you can take it, but it’s never going to address the root of the cause, which could be a leaky gut, hormone imbalance, eating the wrong foods and/or using the wrong products. Still, thousands and thousands of people sign their life away in order to be able to get this drug. It takes an intense toll on your body, and then your skin clears up for a little...but then, a year or two later, it starts to break out again….and then, like many Accutane users report, they’ve got to go back on the medication. It’s the same concept - you can’t just try a short-term solution - *you have to deal with the problem, not the symptoms that arise out of the said problem.* Another hugely popular stimulant, especially among young men, are video games and pornography. And it’s no wonder, considering they both offer a massive dopamine payoff that seems to be almost perfectly tailored to the male biological drive to “master one’s environment.” Research does suggest that playing video games can offer some positive benefits in terms of brain function because it prompts the user to build certain skills and make decisions quickly. But, ultimately, too much screen time, as well as reacting to, and engaging with an artificial environment, is never going to anyone any favors. Rather, you get a numbed mind, and a (temporary) soother for whatever it is you’re trying to ignore. Chronic exercise is probably one thing you didn’t expect to see on this list, but it is a serious issue many people deal with. Unfortunately, people can become addicted to the high they get from working out. This is a lesson I’ve had to learn: how to appropriately balance stress and rest. Of course exercise is healthy, but be careful of crossing that line: when you start to make unhealthy decisions and push your body too far in pursuit of that next dopamine hit, that is when you know you’ve run into trouble: when you’ll do anything to get that high, no matter the consequences. Obviously, we can’t talk about this issue without mentioning social media, one of the biggest culprits here. The problem with social media is that you can’t pick and choose what comes into your orbit - you go on Facebook or Instagram with the intention of reaching out to one specific person, but then you’re bombarded by all this reactive stimulus. This problem has become even worse considering how prevalent ads are on social media apps these days. Are you familiar with the term *neuro-marketing* ? Basically, corporate America has essentially imprisoned us in a loop of endless desire and suffering, with no obvious escape out of this destructive cycle. And why would they want us to escape? That would mean they can’t continue making more money - which is why these corporations exist in the first place. I won’t be calling out any specific brands, but think about all the packaged foods you see every day in grocery stores, the pre-prepared food that you know is filled with bad oils and tons of sugar. It’s not like companies think their product is healthy - quite the opposite, in fact. They just don’t care. There’s a reason why Americans are so plagued by cognitive diseases. Did you know that all cognitive diseases are marked by dysfunctional glucose metabolism? That’s why Alzheimer’s and dementia are also considered to be “Type III diabetes.” When anyone experiences cognitive decline, it’s a huge load placed on the person suffering from the diseases as well as their family members. You would think that these companies, knowing what their “food” does to human health, would be ashamed and embarrassed to produce such a product. But not in America, where profit is the #1 driving force behind everything! And hey, making (and keeping) people sick means that pharmaceutical companies can extract even more money out of sick people! On the bright side, smoking rates have decreased as wellness and healthy eating have gained more and more popularity in the states. But the bad side is, in turn, tobacco and soda and soft drink companies have switched their focus to pushing their capitalist agenda on smaller, less developed countries. Real nice! Once you become aware of the ways that corporate America tries to insidiously hack both your mind and your bank account, you can take some of your power back. Knowledge is power, and this show will open your eyes and your mind to the bigger picture, and empower you to take a personal stand against all the American companies that are trying to give you your next dopamine rush, all so you’ll buy into what they’re selling. Remember the power you hold as the consumer (or as one who doesn’t consume!). And it’s not just consuming anything tangible or physical - it’s also about being hyper-vigilant about what comes into your space and into your mind, especially since what affects the mind manifests in the body as well. Once you know how certain stimuli affect your body, you can decide what you’re going to do about it, instead of just passively reacting to it. *TIMESTAMPS:* American corporations are trying to hijack our dopamine pathways to make profit [6:50]. Hacking your dopamine pathway can affect long-term healing[12:00]. Shopping is just an innocuous activity, but part of the capitalist cycle [16:38]. How corporations use neuro-marketing against you [21:27]. The difference between pleasure and happiness [25:55]. According to Dr. Sinha, FOMO actually has metabolic consequences on your health [30:24]. Marketing hype will make you purchase things you don’t even need [36:00]. “If you want to cure depression, try something you suck at and try to get better [41:00]. Nothing makes you feel better than contributing and volunteering [43:20]. Why talking while driving is more dangerous than listening to music while driving [46:50]. How to get yourself out of the domaine-trigger trap [50:20]. Support this podcast at — https://redcircle.com/the-get-over-yourself-podcast/donations Advertising Inquiries: https://redcircle.com/brands
Switch the B.S. meter to the “on” position, and listen to the wise and powerful Dr. Cate (DrCate.com) address many myths and misconceptions about keto and other ancestral health practices on this hard-hitting show. Brad has avoided caffeine his whole life so he wouldn’t “fry his adrenals.” Dr. Cate calls BS. How about eating in the evening – that makes you store fat, right? Probably doesn't matter that much, says Cate. We know lots of conventional wisdom that has been shattered in recent years by thought leaders in alternative health like Dr. Cate, Mark Sisson, Robb Wolf , and the rest. Now it’s time to get further nuanced with Cate’s examination of some of the stuff even super cool progressive health folks might be stretching reality on. One example is trying to go keto when you aren’t starting out as a healthy fat burner. Everyone talks about the “ keto flu” as something to endure and tolerate on their journey to the promised land. This is simply not true. Of course, we get deep into Cate’s pet crusade against refined high polyunsaturated vegetable oils, called out as the single worst thing you can ingest. These toxic, highly reactive vegetable oils inflict damage at the DNA level immediately upon ingestion to the extent that Dr. Cate says they are, “literally no different than eating radiation.” Speaking of vegetable oil, you can even generate ketones eating a crap load of toxic vegetable oils. You’ll get a keto gold star, and you’ll also feel fatigued and be inactive, and develop insulin resistance, fatty liver, and increase your risk of stroke. This may counter the recent popularity of “dirty keto ” where you are “allowed” to eat a bunch of junk food as long as you hit the requisite macros. Oh yeah, you know those headaches that happen during a busy, sugar crash burnout day? This pattern can become a serious matter whereby you suffer from frequent mini-strokes when your brain is deprived of oxygen due to overconsumption of carbs and the brains over-reliance on sugar. Prominent author Dr. David Perlmutter calls Alzheimer’s “Type III diabetes” due to the close association between insulin resistance and cognitive decline. Good news shared by Dr. Cate is that you can reverse early brain problems and stroke risk by transitioning to a more nutrient-dense , lower sugar, and especially keto friendly diet. This is no funny business, as Dr. Cate offers the stat the typical western diet derives 66 percent of total calories from the big three main most offensive modern foods: sugars, grains, and refined vegetable oils. Dr. Cate is not afraid to call out entities like Harvard University for aggressively promoting nutrient-deficient diets for decades, spurred by corporate influences and the almighty dollar. This is highly disturbing, and greatly inspiring to take matters of health into your own hands. Listeners, you can’t get any better than Dr. Cate when it comes to learning about breaking science and the practical application of simple, do-able, sustainable health practices free of hype and gimmicks and promoting of longevity. Enjoy the show and get things straight. *TIMESTAMPS:* When you’re insulin resistant, pre-diabetic or diabetic, it's very difficult for your body to produce ketones even while following a ketogenic diet. [05:16] Snacking on fat foods will help keep you away from craving sugar. [07:57] There’s no such thing as a healthy snack. [09:34] If people feel bad when they are fasting, it’s called hypoglycemia. [13:04] Our body makes ketones for the brain. [14:02] Most people are not healthy enough to fast for very long because they have this toxic fat and their body is going to resist burning fat and insist on burning sugar. [16:43] Some studies show that a ketogenic diet made out of vegetable oil instead of good fats, you really get fatter. [18:18] If you are working towards a keto diet but you are hungry for a snack, you have to honor that hunger signal. [19:34] Having frequent headaches when you are carb dependency eating pattern, could be a bad sign. [20:33} 99 percent of people who are overweight have a metabolic problem as a core issue that needs to be resolved before they can really regain control. [29:33] Cate talks about the deceit that came out of Harvard studies on nutrition. [31:13] Basically, if the American Heart Association says it’s “heart healthy,” it’s probably a red flag! [33:48] Calories do matter. {38:57] Alcohol is a precursor to acetate and ketones are also a precursor to acetate. [41:58] What is the benefit of caffeine? [44:27] How do supplements play a role? [49:54] We are in a human experiment, eating junk food and seeing how fast we die! [58:31] Many doctors hand out nutrition information that is incorrect. [01:01:01] What helps longevity? [01:03:44] Support this podcast at — https://redcircle.com/the-get-over-yourself-podcast/donations Advertising Inquiries: https://redcircle.com/brands
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