Podcasts about Hash

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  • 1,037PODCASTS
  • 2,670EPISODES
  • 47mAVG DURATION
  • 2DAILY NEW EPISODES
  • Aug 6, 2022LATEST

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Best podcasts about Hash

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Latest podcast episodes about Hash

Late Confirmation by CoinDesk
THE HASH: Headlines - Top Stories of the Week

Late Confirmation by CoinDesk

Play Episode Listen Later Aug 6, 2022 31:03


A roundup of the week's most valuable crypto stories for Saturday, Aug. 6, 2022.Missed any episodes of “The Hash” this week? Today's recap episode will get you caught up.“Hash Headlines” rounds up this week's headline stories, including:Tiffany Unveils $50K CryptoPunk NecklaceNomad Bridge ExploitRobinhood Cuts Workforce by Nearly a QuarterCoinbase Shares Soar Amid BlackRock Partnership NewsIndia Gov't Probing Crypto Exchange WazirX Over Alleged Money LaunderingSee also:Jewelry Brand Tiffany and Co. Unveils $50K CryptoPunk NecklacesCrypto Bridge Nomad Drained of Nearly $200M in ExploitBroker Robinhood Slashing Nearly One-Quarter of WorkforceBlackRock to Offer Crypto for Institutional Investors Through Coinbase PrimeIndian Government Raids Director of Binance-Owned Crypto Exchange WazirX, Freezes $8.14MThis episode has been produced and edited by Michele Musso. Our executive producer is Jared Schwartz. Our theme song is by Matt Wigton “Angeles Crest.”See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

The Adam Dunn Show
TADS072922- Adam Dunn Show - 07 - 29 - 22

The Adam Dunn Show

Play Episode Listen Later Aug 6, 2022 171:29


Hash Rules Everything Around Me…. If you're a grower and you love Cannabis then eventually you figure out that what you really love is hash and my two guests today have definitely walked that path. First we have Pedro @mr.rosins.neighborhood from Pedro‘s Grow Room Pedro is definitely a renaissance man when it comes to Cannabis. He grows it he washes it he presses it he does it all, his passion for the plant is obvious and will make it a point to find out where that all came from as we delve into our Hash episode. Also joining the Hashy conversation Nick Rakkem @rakkems will be telling us what he does to produce the amazing Rosin on his ig page it looks so good you wanna smoke your phone…we will also get an update from @rosindogs from “@Thebestofnewyork” event going down in the big apple he's been working hard, hopefully it's narrowed down to a couple of top contenders. Speaking of which it's that time of the month the last Friday, which means it's another @Iluminarlighting LED light giveaway Tune in and find out who wins and if you entered it could possibly be you! #sagemastaselect #iluminarlighting #SEEEDSHERENOW #Culturedbiologix #pedrosgrowroom #rakkem #warpt4life #davesstillhere #flickinbeans #herbanhouse #landladyproducer

Late Confirmation by CoinDesk
THE HASH: Meta's NFT Push, and India Gov't Probing Crypto Exchange WazirX Over Alleged Money Laundering

Late Confirmation by CoinDesk

Play Episode Listen Later Aug 5, 2022 16:46 Very Popular


The most valuable crypto stories for Friday, Aug. 5, 2022."The Hash" hosts unpack Meta's NFT integration on Instagram platform now live across 100 countries, and Indian authorities freeze the assets of crypto-exchange WazirX.See also: Meta Confirms NFT Rollout Across 100 Countries Amid Coinbase IntegrationIndian Government Raids Director of Binance-Owned Crypto Exchange WazirX, Freezes $8.14MThis episode has been edited by Michele Musso. Our executive producer is Jared Schwartz. Our theme song is “Neon Beach.”See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Empiricus Puro Malte
#102 - É proibido proibir: ghosting, Marx e fintechs quebradas

Empiricus Puro Malte

Play Episode Listen Later Aug 5, 2022 65:21


O papo do quarteto começou com uma reflexão sobre qual é a responsabilidade do Venture Capital quando a investida dá errado. Nas últimas semanas, duas fintechs validadas por grandes placas do VC quebraram -- a Hash e a Virtus. Eles saíram deste tema para outro: em alguma hipótese o ghosting é válido? A pergunta do ouvinte foi sobre FII de tijolo. No quadro Tudo Nosso X Nada deles: telemedicina X ir no consultório; MAC X PC; whey x creatina. Pra encerrar, dicas culturais.- Filme Eduardo e Mônica, no GloboPlay - Disco Dois, do Legião Urbana- Série The Office, episódio sobre budget- Podcast De Carona na Carreira, episódio com Leila Velez- Filme Taxi Driver, na Netlix- Jogo entre Corinthians e Flamengo pela Libertadores, de terça-feira (02/08)- Filme Lightyear, no Disney Plus- Livro Sabor, de Stanley Tucci- Podcast Café com tri, episódio com João Paulo Diniz- Instagram @victorpontes.photoart

Late Confirmation by CoinDesk
THE HASH: Coinbase Shares Soar Amid BlackRock Partnership News, and Robinhood CEO Shuts Down FTX Merger Chatter

Late Confirmation by CoinDesk

Play Episode Listen Later Aug 4, 2022 25:10 Very Popular


The most valuable crypto stories for Thursday, Aug. 4, 2022."The Hash" team unpacks asset management giant BlackRock's (BLK) partnership with crypto exchange Coinbase (COIN) and the Robinhood (HOOD) CEO's response to FTX acquisition rumors.See also: BlackRock to Offer Crypto for Institutional Investors Through Coinbase PrimeRobinhood CEO Shuts Down FTX M&A Chatter, Says He Has Money to Do His Own DealsThis episode has been edited by Michele Musso. Our executive producer is Jared Schwartz. Our theme song is “Neon Beach.”See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Late Confirmation by CoinDesk
THE HASH: Facebook Bets Big on the Creator Economy While Robinhood Cuts Workforce by Nearly a Quarter

Late Confirmation by CoinDesk

Play Episode Listen Later Aug 3, 2022 25:48 Very Popular


The most valuable crypto stories for Wednesday, August 3, 2022."The Hash" hosts discuss a Wall Street Journal report saying that Facebook will bet big on the creator economy. Also, they dive into the Solana wallets hack and the staff layoff at broker Robinhood.See also: Solana Wallets Targeted in Latest Multimillion-Dollar HackBroker Robinhood Slashing Nearly One-Quarter of WorkforceThis episode has been edited by Michele Musso. Our executive producer is Jared Schwartz. Our theme song is “Neon Beach.”See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

The Marty Smith Podcast on Outsider
Hash Browns or Grits?

The Marty Smith Podcast on Outsider

Play Episode Listen Later Aug 2, 2022 88:05 Very Popular


Marty, Wes and Travis chat about Luke Combs' concert, Summer Slam and their go to order at Waffle House. Plus, Colin O'Brady, professional endurance athlete joins the guy to chat about his path to holding 10 world records, rowing across the Drake Passage, walking across Antartica, his new book and a whole lot more.

Late Confirmation by CoinDesk
THE HASH: NFT Platform Magic Eden Expands and Nomad Bridge Exploit

Late Confirmation by CoinDesk

Play Episode Listen Later Aug 2, 2022 20:29 Very Popular


The most valuable crypto stories for Tuesday, August 2, 2022."The Hash" hosts discuss today's top stories, including Solana-based non-fungible token (NFT) marketplace Magic Eden going multichain and the Nomad Bridge exploit that cost the platform nearly $200 million.This episode has been edited by Eleanor Pahl. Our executive producer is Jared Schwartz. Our theme song is “Neon Beach.”See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Late Confirmation by CoinDesk
THE HASH: Tiffany Unveils $50K CryptoPunk Necklace, and OneOf Adds American Express as New Backer

Late Confirmation by CoinDesk

Play Episode Listen Later Aug 1, 2022 19:02 Very Popular


The most valuable crypto stories for Monday, August 1, 2022."The Hash" hosts discuss jewelry maker Tiffany & Co. selling 250 customized, diamond-encrusted CryptoPunk pendant necklaces for 30 ETH a pop to holders of the NFT, and NFT platform OneOf's latest funding round led by the American Express.See also: Jewelry Brand Tiffany and Co. Unveils $50K CryptoPunk NecklacesThis episode has been edited by Michele Musso. Our executive producer is Jared Schwartz. Our theme song is “Neon Beach.”See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Late Confirmation by CoinDesk
THE HASH: HEADLINES - Top Stories of the Week

Late Confirmation by CoinDesk

Play Episode Listen Later Jul 30, 2022 25:29 Very Popular


A roundup of the week's most valuable crypto stories for Saturday, July 30, 2022.Missed any episodes of “The Hash” this week? Today's recap episode will get you caught up.“Hash Headlines” rounds up this week's headline stories, including:The U.S. Federal Reserve raised rates another 75 basis points. A reported Securities and Exchange Commission investigation into crypto exchange Coinbase on suspicions that it allowed trading of unregistered securities.Cathie Wood's Ark Investment Management sold more than 1.4 million shares of Coinbase Global.Facebook parent Meta Platforms lost $2.8 billion on its metaverse division in the second quarter.See also:Federal Reserve Hikes US Interest Rate by 0.75 Percentage PointSEC Probing Coinbase for Allegedly Listing Securities: ReportCathie Wood's Ark Invest Offloads Over 1.4M Coinbase Shares as COIN Price FallsFacebook Parent Meta Loses $2.8B on Metaverse Division in Q2This episode has been produced and edited by Michele Musso. Our executive producer is Jared Schwartz. Our theme song is by Matt Wigton “Angeles Crest.”See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Late Confirmation by CoinDesk
THE HASH: Babel Finance Reportedly Lost $280M Trading Customer Funds, and KuCoin to Offer NFT ETFs

Late Confirmation by CoinDesk

Play Episode Listen Later Jul 29, 2022 26:38 Very Popular


The most valuable crypto stories for Friday, July 29, 2022."The Hash" group discuss a report that troubled crypto lender Babel Finance has lost $280 million in customer funds through proprietary trades, and crypto exchange KuCoin offering retail investors fractional ownership of top non-fungible tokens (NFTs) in the form of an exchange-traded fund (ETF).See also: Babel Finance Lost $280M Trading Customer Funds: ReportKuCoin Claims Bragging Rights as First Exchange to Offer NFT ETFsThis episode has been edited by Michele Musso. Our executive producer is Jared Schwartz. Our theme song is “Neon Beach.”See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Mastering Runeterra
Ep 15 - The Squadcast: A Meta where Ashe Leblanc hit Rank 1 w/ Special Guest Hash

Mastering Runeterra

Play Episode Listen Later Jul 29, 2022 70:03


The Squad have a special guest; Hash! They go over the apocalyptic rise of Bard Illaoi, how Ashe Leblanc got rank one, and how they would like to see Kai'sa 'touched' by the balance team The Squadcast is brought to you by https://masteringruneterra.com/ TimeStamp 0:00 The Squad featuring Special Guest Hash! 0:45 Ladder has Changed... Bard Illaoi's rise 8:30 Monte's Prediction; Bard Illaoi + Jayce Heimer will be the pivotal lineup core 10:30 Bard Illaoi is proving to be quite skill expressive 19:20 TF Annie is more annoying than Bard Illaoi 24:00 Irelia Azir & Kaisa are still big; THE SHURIMAN DESERT REIGNS 31:50 Yasuo is IN THE META... As a non-champion for the hillock deck 38:20 Ashe Leblanc is a valid meta call 42:00 Roundtable on how to fix/nerf Kai'sa 58:35 Lulu PnZ is good.... except with Bard Illaoi EVERYWHERE 1:08:00 Final Thoughts Patreon Team: https://www.patreon.com/MasteringRuneterra Join Discord! https://discord.gg/TqnntWF728 Podcast: https://podcasts.apple.com/ca/podcast/mastering-runeterra/id1556960343 https://open.spotify.com/show/49xjHNbzVwG9ZEurUQH8Qn Twitter: https://twitter.com/MasterRuneterra Guest Hash's Socials: https://twitter.com/hashx27 MonteXristo's Socials: https://twitter.com/MonteXristoLoR https://www.twitch.tv/Monte_Xristo Shadawx's Socials: https://twitter.com/shadawx https://twitch.tv/shadawx https://www.youtube.com/channel/UCpgbie3tmI07MZJ5X5b5MYQ CardGamer's Social: https://twitter.com/CardGamerLoR Phansora's Socials: https://twitter.com/phansoraLOR Discord: Phansora8075 SantaTCG's Social: https://twitter.com/santatcg Cameron Hanzo's Social: https://twitter.com/CameronHanzo Prodigy's Socials: https://twitter.com/prodigy_lor #LegendsofRuneterra #LoR #PlayRuneterra #LoRPodcast

Good Risings
62.5. Hash It Out: Understanding Physical Affection

Good Risings

Play Episode Listen Later Jul 29, 2022 3:59


Good Risings is a mindset. Join Elizabeth Earnshaw for a daily dose of Advice.   Presented By: Cavalry Audio.    Producers: Jason Seagraves & Margot Carmichael.       Audio Editing: Revision Sound.   Music: Gramoscope Music.    Executive Producers: Elizabeth Earnshaw, Dana Brunetti & Keegan Rosenberger.    You can now search all of the Good Risings episodes on Fathom.fm/GoodRisings!See omnystudio.com/listener for privacy information.

Good Risings
62.4. Hash It Out: Healing from an Abusive Past

Good Risings

Play Episode Listen Later Jul 28, 2022 6:07


Good Risings is a mindset. Join Elizabeth Earnshaw for a daily dose of Advice.   Presented By: Cavalry Audio.    Producers: Jason Seagraves & Margot Carmichael.       Audio Editing: Revision Sound.   Music: Gramoscope Music.    Executive Producers: Elizabeth Earnshaw, Dana Brunetti & Keegan Rosenberger.    You can now search all of the Good Risings episodes on Fathom.fm/GoodRisings!See omnystudio.com/listener for privacy information.

Hill-Man Morning Show Audio
Jared Weiss joins the show to hash things out with Wiggy

Hill-Man Morning Show Audio

Play Episode Listen Later Jul 28, 2022 41:40


Hour 3 Wiggy heard grumblings that Jaylen was displeased with the Celtics front office that is leading many to believe these last trade offers to obtain KD might have been the last straw for Jaylen to remain in Boston once his contract is up. Is it fair for players to hold grudges against their employers?  Jared Weiss calls in to go over what Wiggy had shared on Twitter and the resulting article in The Athletic. Sam Kennedy made the claim that Cora and Chaim are the best manager-GM duo he's seen despite being around for Theo and Francona.

Late Confirmation by CoinDesk
THE HASH: Bitcoin Tops $23K Amid US Recession and Facebook Parent Meta Loses $2.8B on Metaverse Division in Q2

Late Confirmation by CoinDesk

Play Episode Listen Later Jul 28, 2022 28:53


The most valuable crypto stories for Thursday, July 28, 2022Gross domestic product declined at an annualized pace of 0.9% in the second quarter, marking two consecutive quarters of economic contraction. "The Hash" team discusses what that means for the crypto market. Plus, a closer look at Meta Platform's latest earnings results.See also: Facebook Parent Meta Loses $2.8B on Metaverse Division in Q2Bitcoin Market Awaits US GDP After Biggest Single-Day Gain in 6 WeeksThis episode was edited by Michele Musso and our executive producer is Jared Schwartz. Our theme song is “Neon Beach.”See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Late Confirmation by CoinDesk
THE HASH: Ethereum's Mainnet Shadow Fork 10 Goes Live, and Cathie Wood's Ark Invest Offloads 1.4M Coinbase Shares

Late Confirmation by CoinDesk

Play Episode Listen Later Jul 27, 2022 18:40 Very Popular


The most valuable crypto stories for Wednesday, July 27, 2022."The Hash" team discusses Ethereum's 10th shadow fork going into effect 26 hours earlier than expected and Cathie Wood's Ark Investment Management selling more than 1.4 million shares of Coinbase Global on Tuesday.See also: Cathie Wood's Ark Invest Offloads Over 1.4M Coinbase Shares as COIN Price Falls Ethereum's Rollup Race: What is a ‘True' zkEVM?This episode was edited by Michele Musso and our executive producer is Jared Schwartz. Our theme song is “Neon Beach.”See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Good Risings
62.3. Hash It Out: Reasons for Affairs

Good Risings

Play Episode Listen Later Jul 27, 2022 5:20


Good Risings is a mindset. Join Elizabeth Earnshaw for a daily dose of Advice.   Presented By: Cavalry Audio.    Producers: Jason Seagraves & Margot Carmichael.       Audio Editing: Revision Sound.   Music: Gramoscope Music.    Executive Producers: Elizabeth Earnshaw, Dana Brunetti & Keegan Rosenberger.    You can now search all of the Good Risings episodes on Fathom.fm/GoodRisings!See omnystudio.com/listener for privacy information.

Late Confirmation by CoinDesk
THE HASH: Coinbase Shares Fall Amid Reported SEC Probe, and Chipotle Pushes Into Crypto Space

Late Confirmation by CoinDesk

Play Episode Listen Later Jul 26, 2022 21:16 Very Popular


The most valuable crypto stories for Tuesday, July 26, 2022."The Hash" hosts discuss a reported SEC investigation into crypto exchange Coinbase on suspicions that it allowed U.S. persons to trade unregistered securities. And the latest interactive game that allows users to win up to $200,000 in crypto rewards is from Chipotle. See also: SEC Probing Coinbase for Allegedly Listing Securities: ReportThis episode was edited by Michele Musso and our executive producer is Jared Schwartz. Our theme song is “Neon Beach.”See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Dom, Meg & Randell Catchup Podcast - The Edge
FULL SHOW - 26 JULY 2022: Buying 100 Hash Browns?!

Dom, Meg & Randell Catchup Podcast - The Edge

Play Episode Listen Later Jul 26, 2022 71:35


Yo yo!  On today's show, we tried to buy 100 hash browns from maccas, we found out if Nickson's wife Sarah actually likes her engagement ring and we were the first people in the world to hear some new songs...  Enjoy! See omnystudio.com/listener for privacy information.

West Coast Cookbook & Speakeasy
West Coast Cookbook and Speakeasy - River City Hash Mondays 25 July 22

West Coast Cookbook & Speakeasy

Play Episode Listen Later Jul 26, 2022 63:04


West Coast Cookbook & Speakeasy is Now Open! 8am-9am PT/ 11am-Noon ET for our especially special Daily Specials; River City Hash Mondays!Starting off in the Bistro Cafe, despite warnings from Liz Cheney, all signs point to Republicans standing by Donald Trump as he hints at running for President again.Then, on the rest of the menu, energy experts say the Republican outrage over petroleum reserve sales is overblown; GOP representative Ted Budd of North Carolina got big bucks for opposing consumer protections against predatory lending, despite his own state prohibiting the practice; and, the FBI says it busted a big crypto Ponzi scam, but then they discovered it was even bigger.After the break, we move to the Chef's Table where Japan's nuclear regulator approved a planned release of treated radioactive wastewater from the still-wrecked Fukushima nuclear power plant into the sea next year; and, China launched one of two laboratory modules to complete its permanent orbiting space station.All that and more, on West Coast Cookbook & Speakeasy with Chef de Cuisine Justice Putnam.Bon Appétit!~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~"I was never a spy. I was with the OSS organization. We had a number of women, but we were all office help." -- Julia Child~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~Show Notes & Links: https://www.dailykos.com/stories/2022/7/25/2112386/-West-Coast-Cookbook-amp-Speakeasy-Daily-Special-River-City-Hash-Mondays

Good Risings
62.2. Hash It Out: Stages of a Relationship

Good Risings

Play Episode Listen Later Jul 26, 2022 3:43


What does it mean to love other people in normal day to day lives.  It's normal to feel anxiety as your relationship moves into another stage.   Good Risings is a mindset. Join Elizabeth Earnshaw for a daily dose of Advice. Presented By: Cavalry Audio.  Producers: Jason Seagraves & Margot Carmichael.   Audio Editing: Revision Sound. Music: Gramoscope Music.  Executive Producers: Elizabeth Earnshaw, Dana Brunetti & Keegan Rosenberger.  Learn more about your ad-choices at https://www.iheartpodcastnetwork.com You can now search all of the Good Risings episodes on Fathom.fm/GoodRisings! See omnystudio.com/listener for privacy information.

Late Confirmation by CoinDesk
THE HASH: Bitcoin Drops as Markets Await Another Fed Rate Hike, and a Twitter Data Breach

Late Confirmation by CoinDesk

Play Episode Listen Later Jul 25, 2022 19:47 Very Popular


The most valuable crypto stories for Monday, July 25, 2022."The Hash" team dissects today's top stories. The Federal Reserve is expected to raise rates another 75 basis points, as tech giants Alphabet and Meta Platforms report their second-quarter earnings. A huge data breach at Twitter exposes contact details of 5.4 million accounts. Plus, can Aptos Labs bring the Diem blockchain back to life after announcing a $150 million funding round? This episode was edited by Michele Musso and our executive producer is Jared Schwartz. Our theme song is “Neon Beach.”See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

CSO Perspectives (public)
Enterprise backups around the Hash Table.

CSO Perspectives (public)

Play Episode Listen Later Jul 25, 2022 23:07


Enterprise backups as a cybersecurity first principle strategy. This session covers the riveting topic of enterprise backup schemes to improve resilience. Rick discusses the value of data backups, workflow models, recent ransomware trends, and platforms for each use case. The Hash Table provides tangible enterprise backup strategies that encompass centralized, decentralized, and DevSecOps techniques, business continuity and disaster recovery plans, and engaging the Executive team in crisis scenarios and recovery training. In data backups, nothing is easy, but Rick breaks it down to first principles and makes it understandable. With Rick Howard, the CyberWire's CSO and Chief Analyst, joined by Jerry Archer, the Sallie Mae CSO, and Jaclyn Miller, the CISO for NTT, discuss enterprise backups as a first principle strategy. Cybersecurity professional development and continued education. You will learn about: backup tools and platforms, workflow responsibilities and models, disaster recovery and business continuity plans, backups as a tool to improve resilience CyberWire is the world's most trusted news source for cybersecurity information and situational awareness. Join the conversation with Rick Howard on LinkedIn and Twitter, and follow CyberWire on social media and join our community of security professionals: LinkedIn, Twitter, Youtube, Facebook, Instagram Additional first principles resources for your cybersecurity program. For more enterprise backups and cybersecurity first principles resources, check the topic essay.

Good Risings
62.1. Hash It Out: How Could You Even Ask?

Good Risings

Play Episode Listen Later Jul 25, 2022 4:56


How to start difficult conversation in the "just right way." Good Risings is a mindset. Join Elizabeth Earnshaw for a daily dose of Advice. Presented By: Cavalry Audio.  Producers: Jason Seagraves & Margot Carmichael.   Audio Editing: Revision Sound. Music: Gramoscope Music.  Executive Producers: Elizabeth Earnshaw, Dana Brunetti & Keegan Rosenberger.  Learn more about your ad-choices at https://www.iheartpodcastnetwork.com You can now search all of the Good Risings episodes on Fathom.fm/GoodRisings! See omnystudio.com/listener for privacy information.

Late Confirmation by CoinDesk
THE HASH: Hash Headlines – Top Stories of the Week

Late Confirmation by CoinDesk

Play Episode Listen Later Jul 23, 2022 39:27 Very Popular


A roundup of the week's most valuable crypto stories for Saturday, July 23, 2022.Missed any episodes of “The Hash” this week? Today's recap episode will get you caught up.“Hash Headlines” rounds up this week's headline stories, including:Celsius Network outlining its next steps as the insolvent crypto lender's bankruptcy hearing starts.Court documents indicate a connection between crypto trading firm TPS Capital and Three Arrows Capital.The latest on inflation in the U.S.The arrest of a former Coinbase product manager on charges of wire fraud and insider trading.The founders of insolvent crypto hedge fund Three Arrows Capital have broken their silence in an interview with Bloomberg.This episode was edited by Eleanor Pahl and our executive producer is Jared Schwartz. Our theme song is “Neon Beach.”See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Late Confirmation by CoinDesk
THE HASH: Crypto Fund Three Arrows Capital Founders Break Their Silence and Lender Nexo Faces Declining Deposits

Late Confirmation by CoinDesk

Play Episode Listen Later Jul 22, 2022 27:13 Very Popular


The most valuable crypto stories for Friday, July 22, 2022.The founders of insolvent crypto hedge fund Three Arrows Capital have broken their silence in an interview with Bloomberg. "The Hash" team discusses the latest revelations as the duo denies claims they pulled money from the fund before its collapse. Plus, a closer look at crypto lender Nexo's attestations.This episode was edited by Eleanor Pahl and our executive producer is Jared Schwartz. Our theme song is “Neon Beach.”See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Late Confirmation by CoinDesk
THE HASH: Ex-Coinbase Manager Among 3 Arrested on Crypto Insider Trading Charges; Tesla Sells 75% of Its Bitcoin

Late Confirmation by CoinDesk

Play Episode Listen Later Jul 21, 2022 27:16 Very Popular


The most valuable crypto stories for Thursday, July 21, 2022."The Hash" discusses the top stories of the day, including the arrest of a former Coinbase product manager on charges of wire fraud and insider trading. Plus, the panel weighs in on Tesla CEO Elon Musk's future bitcoin (BTC) plans, after the electric vehicle maker sold the majority of its BTC holdings in the second quarter.This episode was edited by Eleanor Pahl and our executive producer is Jared Schwartz. Our theme song is “Neon Beach.”See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Discover CircRes
July 2022 Discover Circ Res

Discover CircRes

Play Episode Listen Later Jul 21, 2022 38:42


This month on Episode 38 of Discover CircRes, host Cynthia St. Hilaire highlights original research articles featured in the Jue 24th, July 8th and July 22nd issues of the journal. This episode also features an interview with the 2022 BCBS Outstanding Early Career Investigator Award finalists, Dr Hisayuki Hashimoto, Dr Matthew DeBerge and Dr Anja Karlstadt.   Article highlights:   Nguyen, et al. miR-223 in Atherosclerosis.   Choi, et al. Mechanism for Piezo1-Mediated Lymphatic Sprouting   Kamtchum-Tatuene, et al.  Plasma Interleukin-6 and High-Risk Carotid Plaques   Li, et al. 3-MST Modulates BCAA Catabolism in HFrEF   Cindy St. Hilaire:        Hi, and welcome to Discover CircRes, the podcast of the American Heart Association's journal, Circulation Research. I'm your host, Dr Cindy St. Hilaire, from the Vascular Medicine Institute at the University of Pittsburgh. And today I'm going to be highlighting articles from our June 24th, July 8th and July 22nd issues of Circulation Research. I'm also going to have a chat with the finalists for the 2022 BCBS Outstanding Early Career Investigator Award, Dr Hisayuki Hashimoto, Dr Matthew DeBerge and Dr Anja Karlstadt.   Cindy St. Hilaire:        The first article I want to share is from our June 24th issue and is titled, miR-223 Exerts Translational Control of Proatherogenic Genes in Macrophages. The first authors are My-Anh Nguyen and Huy-Dung Hoang, and the corresponding author is Katey Rayner and they're from the University of Ottawa. A combination of cholesterol accumulation in the blood vessels and subsequent chronic inflammation that's derived from this accumulation drive the progression of atherosclerosis. Unfortunately, current standard medications tackle just one of these factors, the cholesterol. And this might explain why many patients on such drugs still have vascular plaques. In considering treatments that work on both aspects of the disease, meaning lipid accumulation and inflammation, this group investigated the micro RNA 223 or miR-223, which is a small regulatory RNA that has been shown to suppress expression of genes involved in both cholesterol uptake and inflammatory pathways in both liver and immune cells.   Cindy St. Hilaire:        The team showed that mouse macrophages deficient in miR-223, exhibited increased expression of pro-inflammatory cytokines and reduced cholesterol efflux compared with control cells. Overexpression of miR-223 had the opposite effects. Furthermore, atherosclerosis prone mice, whose hematopoietic cells lacked miR-223, had worse atherosclerosis with larger plaques and higher levels of pro-inflammatory cytokines than to control animals with normal levels of miR-223. These findings highlight miR-223's dual prompt, antiatherogenic action, which could be leveraged for future therapies.   Cindy St. Hilaire:        The second article I want to share is from our July 8th issue of Circulation Research and is titled, Piezo1-Regulated Mechanotransduction Controls Flow-Activated Lymph Expansion. The first author is Dongwon Choi and the corresponding author is Young-Kwon Hong, and they're from UCLA.   As well as being super highways for immune cells, lymph vessels are drainage channels that help maintain fluid homeostasis in the tissues. This network of branching tubes grows as fluids begin to flow in the developing embryo. This fluid flow induces calcium influx into the lymphatic endothelial cells, which in turn promotes proliferation and migration of these cells, leading to the sprouting of lymph tubules. But how do LECs, the lymphatic endothelial cells, detect fluid flow in the first place? Piezo1 is a flow and mechanosensing protein known for its role in blood vessel development and certain mutations in Piezo1 cause abnormal lymphatic growth in humans.   Cindy St. Hilaire:        This script found that Piezo1 is expressed in the embryonic mouse LECs and that the suppression of Piezo1 inhibits both flow activated calcium entry via the channel ORAI1, as well as downstream target gene activation. Overexpression of Piezo1, by contrast, induced the target genes. The team went on to show that mice lacking either Piezo1 or ORAI1 had lymphatic sprouting defects and that pharmacological activation of Piezo1 in mice enhanced lymphogenesis and prevented edema after tail surgery. Together, the results confirmed Piezo1's role in flow dependent lymphatic growth and suggest it might be a target for treating lymphedema.   Cindy St. Hilaire:        The third article I want to share is also from our July 8th issue and is titled, Interleukin-6 Predicts Carotid Plaque Severity, Vulnerability and Progression. The first and corresponding author of this study is Joseph Kamtchum-Tatuene from University of Alberta.   Excessive plasma cholesterol and systemic inflammation are contributing factors in atherosclerosis. While traditional remedies have been aimed at lowering patient's lipid levels, drugs that tackle inflammation are now under investigation, including those that suppress Interleukin-6, which is an inflammatory cytokine implicated in the disease. Focusing on carotid artery disease, this group conducted a prospective study to determine whether IL-6 levels correlated with disease severity. 4,334 individuals were enrolled in the cardiovascular health study cohort. They had their blood drawn and ultrasounds taken at the start of the study and five years later. This group found IL-6 was robustly correlated with and predicted plaque severity independent of other cardiovascular risk factors. This study also determined that an IL-6 blood plasma level of 2.0 picograms/mls, identified individuals with the highest likelihood of plaque, vulnerability and progression. This threshold value could be used to select patients who might benefit from novel IL-6 lowering medications.   Cindy St. Hilaire:        The last article I want to share is from our July 22nd issue of Circulation Research and is titled, Mitochondrial H2S Regulates BCAA Catabolism in Heart Failure. The first author is Zhen Li, and the corresponding author is David Lefer from Louisiana State University. Hydrogen sulfide, or H2S, is a compound that exerts mitochondrial specific actions that include the preservation of oxidative phosphorylation, mitochondrial biogenesis and ATP synthesis, as well as inhibiting cell death. 3-mercaptopyruvate sulfurtransferase, or 3-MST, is a mitochondrial H2S producing enzyme, whose functions in cardiovascular disease are not fully understood.   Cindy St. Hilaire:        This group investigated the global effects of 3-MST deficiency in the setting of pressure overload induced heart failure. They found that 3-MST was significantly reduced in the myocardium of patients with heart failure, compared with non failing controls. 3-MST knockout mice exhibited increased accumulation of branch chain amino acids in the myocardium, which was associated with reduced myocardial respiration and ATP synthesis, exacerbated cardiac and vascular dysfunction, and worsened exercise performance, following transverse aortic constriction. Restoring myocardial branched-chain amino acid catabolism, or administration of a potent H2S donor, ameliorated the detrimental effects of 3-MST deficiency and heart failure with reduced injection fraction. These data suggest that 3-MST derived mitochondrial H2S, may play a regulatory role in branch chain amino acid catabolism, and mediate critical cardiovascular protection in heart failure.   Cindy St. Hilaire:        Today, I'm really excited to have our guests, who are the finalists for the BCVS Outstanding Early Career Investigator Awards. Welcome everyone.   Hisayuki Hashimoto:   Thank you.   Anja Karlstaedt:          Hi.   Hisayuki Hashimoto:   Hi.   Matthew DeBerge:      Hello. Thank you.   Cindy St. Hilaire:        So the finalists who are with me today are Dr Hisayuki Hashimoto from Keio University School of Medicine in Tokyo, Japan, Dr Matthew Deberge from Northwestern University in Chicago and Dr Anja Karlstaedt from Cedar Sinai Medical Center in LA. Thank you again. Congratulations. And I'm really excited to talk about your science.   Hisayuki Hashimoto:   Thank you. Yes. Thanks, first of all for this opportunity to join this really exciting group and to talk about myself and ourselves. I am Hisayuki Hashimoto, I'm from Tokyo, Japan. I actually learned my English... I went to an American school in a country called Zaire in Africa and also Paris, France because my father was a diplomat and I learned English there. After coming back to Japan, I went to medical school. During my first year of rotation, I was really interested in cardiology, so I decided to take a specialized course for cardiology. Then I got interested in basic science, so I took a PhD course, and that's what brought me to this cardiology cardiovascular research field.   Matthew DeBerge:      So I'm currently a research assistant professor at Northwestern University. I'm actually from the Chicagoland area, so I'm really excited to welcome you all to my hometown for the BCVS meeting.   Cindy St. Hilaire:        Oh, that's right. And AHA is also there too this year. So you'll see a lot of everybody.   Matthew DeBerge:      I guess I get the home field advantage, so to speak. So, I grew up here, I did my undergrad here, and then went out in the east coast, Dartmouth College in New Hampshire for my PhD training. And actually, I was a viral immunologist by training, so I did T cells. When I was looking for a postdoctoral position, I was looking for a little bit of something different and came across Dr Edward Thorpe's lab at Northwestern university, where the interest and the focus is macrophages in tissue repair after MI. So, got into the macrophages in the heart and have really enjoyed the studies here and have arisen as a research assistant professor now within the Thorpe lab. Now we're looking to transition my own independent trajectory. Kind of now looking beyond just the heart and focusing how cardiovascular disease affects other organs, including the brain. That's kind of where I'm starting to go now. Next is looking at the cardiovascular crosstalk with brain and how this influences neuroinflammation.   Anja Karlstaedt:          I am like Hisayuki, I'm also a medical doctor. I did my medical training and my PhD in Berlin at the Charité University Medicine in Berlin, which is a medical faculty from Humboldt University and Freie University. II got really interested in mathematical modeling of complex biological systems. And so I started doing my PhD around cardiac metabolism and that was a purely core and computationally based PhD. And while I was doing this, I got really hooked into metabolism. I wanted to do my own experiments to further advance the model, but also to study more in crosstalk cardiac metabolism. I joined Dr Heinrich Taegteyer lab at the University of Texas in the Texas Medical Center, and stayed there for a couple of years. And while I was discovering some of the very first interactions between leukemia cells and the heart, I decided I cannot stop. I cannot go back just after a year. I need to continue this project and need to get funding. And so after an AHA fellowship and NIHK99, I am now here at Cedars Sinai, an assistant professor in cardiology and also with a cross appointment at the cancer center and basically living the dream of doing translational research and working in cardio-oncology.   Cindy St. Hilaire:        Great. So, Dr Hashimoto, the title of your submission is, Cardiac Reprogramming Inducer ZNF281 is Indispensable for Heart Development by Interacting with Key Cardiac Transcriptional Factors. This is obviously focused on reprogramming, but why do we care about cardiac reprogramming and what exactly did you find about this inducer ZNF281?   Hisayuki Hashimoto:   Thank you for the question. So, I mean, as I said, I'm a cardiologist and I was always interested in working heart regeneration. At first, I was working with pluripotent stem cells derived cardiomyocyte, but then I changed my field during my postdoc into directly programming by making cardiomyocyte-like cells from fiberblast. But after working in that field, I kind of found that it was a very interesting field that we do artificially make a cardiomyocyte-like cell. But when I dissected the enhanced landscape, epigenetic analysis showed that there are very strong commonalities between cardiac reprogramming and heart development. So I thought that, hey, maybe we can use this as a tool to discover new networks of heart development. And the strength is that cardiac reprogramming in vitro assay hardly opens in vivo assay, so it's really time consuming. But using dark programming, we can save a lot of time and money to study the cardiac transitional networks. And we found this DNF281 from an unbiased screen, out of 1000 human open reading frames. And we found that this gene was a very strong cardiac reprogramming inducer, but there was no study reporting about any functioning heart development. We decided to study this gene in heart development, and we found out that it is an essential gene in heart development and we were kind of able to discover a new network in heart development.   Cindy St. Hilaire:        And you actually used, I think it was three different CRE drivers? Was that correct to study?   Hisayuki Hashimoto:   Ah, yes. Yeah.   Cindy St. Hilaire:        How did you pick those different drivers and what, I guess, cell population or progenitor cell population did those drivers target?   Hisayuki Hashimoto:   So I decided to use a mesodermal Cre-driver, which is a Mesp1Cre and a cardiac precursor Cre-driver, which is the Nkx2-5 Cre and the cardiomyocyte Cre, which is the Myh6-Cre. So three differentiation stages during heart development, and we found out that actually, DNF281 is an essential factor during mesodermal to cardiac precursor differentiation state. We're still trying to dig into the molecular mechanism, but at that stage, if the DNF281 is not there, we are not able to make up the heart.   Cindy St. Hilaire:        That is so interesting. Did you look at any of the strains that survived anyway? Did you look at any phenotypes that might present in adulthood? Is there anything where the various strains might have survived, but then there's a kind of longer-term disease implicating phenotype that's observed.   Hisayuki Hashimoto:   Well, thank you for the question. Actually, the mesodermal Cre-driver knocking out the DNF281 in that stage is embryonic lethal, and it does make different congenital heart disease. And they cannot survive until after embryonic day 14.5. The later stage Nkx2-5 Cre and Myh6-Cre, interestingly, they do survive after birth. And then in adult stage, I did also look into the tissues, but the heart is functioning normally. I haven't stressed them, but they develop and they're alive after one year. It looks like there's really no like phenotype at like the homeostatic status.   Cindy St. Hilaire:        Interesting. So it's kind of like, once they get over that developmental hump, they're okay.   Hisayuki Hashimoto:   Exactly. That might also give us an answer. What kind of network is important for cardiac reprogramming?   Cindy St. Hilaire:        So what are you going to do next?   Hisayuki Hashimoto:   Thank you. I'm actually trying to dig into the transitional network of what kind of cardiac transitional network the ZNF281 is interacting with, so that maybe I can find a new answer to any etiology of congenital heart disease, because even from a single gene, different mutation, different variants arise different phenotypes in congenital heart disease. Maybe if I find a new interaction with any key cardiac transitional factors, maybe I could find a new etiology of congenital heart disease phenotype.   Cindy St. Hilaire:        That would be wonderful. Well, best of luck with that. Congratulations on an excellent study. Hisayuki Hashimoto:   Thank you.   Cindy St. Hilaire:        Dr DeBerge, your study was titled, Unbiased Discovery of Allograft Inflammatory Factor-1 as a New and Critical Immuno Metabolic Regulatory Node During Cardiac Injury. Congrats on this very cool study. You were really kind of focused on macrophages in myocardial infarction. And macrophages, they're a Jeckel Hyde kind of cell, right? They're good. They're bad. They can be both, almost at the same time, sometimes it seems like. So why were you interested in macrophages particularly in myocardial infarction, and what did you discover about this allograft inflammatory factor-1, or AIF1 protein?   Matthew DeBerge:      Thank you. That's the great question. You really kind of alluded to why we're interested in macrophages in the heart after tissue repair. I mean, they really are the central mediators at both pro-inflammatory and anti-inflammatory responses after myocardial infarction. Decades of research before this have shown that inflammation has increased acutely after MI and has also increased in heart failure patients, which really has led to the development of clinical efforts to target inflammatory mediators after MI. Now, unfortunately, the results to target inflammation after MI, thus far, have been modest or disappointing, I guess, at worst, in the respect that broadly targeting macrophage function, again, hasn't achieved results. Again, because these cells have both pro and anti-inflammatory functions and targeting specific mediators has been somewhat effective, but really hasn't achieved the results we want to see.   Matthew DeBerge:      I think what we've learned is that the key, I guess, the targeting macrophage after MI, is really to target their specific function. And this led us to sort of pursue novel proteins that are mediating macrophage factor function after MI. To accomplish this, we similarly performed an unbiased screen collecting peri-infarct tissue from a patient that was undergoing heart transplantation for end stage heart failure and had suffered an MI years previously. And this led to the discovery of allograft inflammatory factor-1, or AIF1, specifically within cardiac macrophages compared to other cardiac cell clusters from our specimen. And following up with this with post-mortem specimens after acute MI to show that AIF1 was specifically increased in macrophages after MI and then subsequently then testing causality with both murine model of permanent inclusion MI, as well as in vitro studies using bone marrow drive macrophages to dig deeper mechanistically, we found that AIF1 was crucial in regulating inflammatory programing macrophages, which ultimately culminated in worse in cardiac repair after MI.   Cindy St. Hilaire:        That's really interesting. And I love how you start with the human and then figure out what the heck it's doing in the human. And one of the things you ended up doing in the mouse was knocking out this protein AIF1, specifically in macrophage cells or cells that make the macrophage lineage. But is this factor in other cells? I was reading, it can be intracellular, it can be secreted. Are there perhaps other things that are also going on outside of the macrophage?   Matthew DeBerge:      It's a great question. First, I guess in terms of specificity, within the hematopoietic compartment, previous studies, as well as publicly available databases, have shown that AIF1 is really predominantly expressed within macrophages. We were able to leverage bone marrow chimera mice to isolate this defect to the deficiency to macrophages. But you do bring up a great point that other studies have shown that AIF1 may be expressed in other radio-resistant cell populations. I mean, such as cardiomyocytes or other treatable cells within the heart. We can't completely rule out a role for AIF1 and other cell populations. I can tell you that we did do the whole body knockout complementary to our bone marrow hematopoetic deficient knockouts, and saw that deficiency of AIF1 within the whole animal, recapitulate the effects we saw within the AIF1 deficiency within hematopoietic department.   Matthew DeBerge:      It was encouraging to us that, again, the overall role of AIF1 is pro-inflammatory after MI.   Cindy St. Hilaire:        I mean, I know it's early days, but is there a hint of any translational potential of these findings or of this protein?   Matthew DeBerge:      Yeah, I think so. To answer your question, we were fortunate enough to be able to partner with Ionis that develops these anti-sensible nucleotides so that we could specifically target AIF1 after the acute phase during MI. We saw that utilizing these anti-sensible nucleotides to deplete AIF1, again, within the whole mouse, that we were able to reduce inflammation, reduce in heart size and preserve stock function. I think there really is, hopefully a therapeutic opportunity here. And again, with it being, perhaps macrophage specific is, even much more important as we think about targeting the specific function of these cells within the heart.   Cindy St. Hilaire:        Very cool stuff. Dr Karlstaedt, the title of your submission is, ATP Dependent Citrate Lyase Drives Metabolic Remodeling in the Heart During Cancer. So this I found was really interesting because you were talking about, the two major killers in the world, right? Cardiovascular disease and cancer, and you're just going to tackle both of them, which I love. So obviously this is built on a lot of prior observations about the effects of cancer on cardiac metabolic remodeling. Can you maybe just tell us a little bit about what is that link that was there and what was known before you started?   Anja Karlstaedt:          Yeah. Happy to take that question. I think it's a very important one and I'm not sure if I will have a comprehensive answer to this, because like I mentioned at the beginning, cardio-oncology is a very new field. And the reason why we are starting to be more aware of cancer patients and their specific cardiovascular problems is because the cancer field has done such a great job of developing all these new therapeutics. And we have far more options of treating patients with various different types of cancers in particular, also leukemias, but also solid tumors. And what has that led to is an understanding that patients survive the tumors, but then 10, 20 years later, are dying of cardiovascular diseases. Those are particular cardiomyopathies and congestive heart failure patients. What we are trying, or what my lab is trying to do, is understanding what is driving this remodeling. And is there a way that we can develop therapies that can basically, at the beginning of the therapy, protect the heart so that this remodeling does not happen, or it is not as severe.   Anja Karlstaedt:          Also, identifying patients that are at risk, because not every tumor is created equally and tumors are very heterogeneous, even within the same group. To get to your question, what we found is, in collaboration actually with a group at Baylor College of Medicine, Peggy Goodell's group, who is primarily working on myeloid malignancies, is that certain types of leukemias are associated with cardiomyopathies. And so when they were focusing on the understanding drivers of leukemia, they noticed that the hearts of these animals in their murine models are enlarged on and actually developing cardiomyopathies. And I joined this project just very early on during my postdoc, which was very fortunate and I feel very lucky of having met them. What my lab is now studying here at Cedars is how basically those physiological stress and mutations coming from the tumors are leading to metabolic dysregulation in the heart and then eventually disease.   Anja Karlstaedt:          And we really think that metabolism is at the center of those disease progressions and also, because it's at the center, it should be part of the solution. We can use it as a way to identify patients that are at risk, but also potentially develop new therapies. And what was really striking for us is that when we knock down ACLY that in a willdtype heart where the mouse doesn't have any tumor disease, ACLY actually is critically important for energy substrate metabolism, which seems counterintuitive, because it's far away from the mitochondria, it's not part of directly ADP provision. It's not part of the Kreb cycle. But what we found is that when we knock it out using a CRISPR-Cas9 model, it leads to cardiomyopathy and critically disrupts energy substrate metabolism. And that is not necessarily the case when the mouse has leukemia or has a colorectal cancer, which upregulated in the beginning, this enzyme expression. And so we have now developed models that show us that this could be potentially also therapeutic target to disrupt the adverse remodeling by the tumor.   Cindy St. Hilaire:        That is so interesting. So one of the things I was thinking about too is we know that, I mean, your study is showing that, the tumor itself is causing cardiac remodeling, but we also know therapies, right? Radiation, chemotherapy, probably some immune modulatory compounds. Those probably do similar, maybe not exactly similar, but they also cause, adverse cardiac remodeling. Do you have any insights as to what is same and what is different between tumor driven and therapy driven adverse remodeling?   Anja Karlstaedt:          So we do not know a lot yet. It's still an open question about all the different types of chemotherapeutics, how they are leading to cardio toxicities. But what we know, at least from the classic anti-cyclic treatments, is right now at the core, the knowledge is that this is primarily disrupting cardiac mitochondrial function. And through that again, impairing energy provision and the interaction, again, with the immune system is fairly unknown, but we know through studies from Kathryn Moore and some very interesting work by Rimson is that myocardial infarction itself can lead to an increase in risk for tumor progression. And what they have shown as independent of each other, is that the activation of the immune system in itself can lead to an acceleration of both diseases, both the cardiac remodeling, and then also the tumor disease. We don't fully understand which drivers are involved, but we do know that a lot of the cardiomyopathies on cardiotoxicities that are chemotherapeutically driven, all have also metabolic component.   Cindy St. Hilaire:        Nice. Thank you. When I prepare for these interviews, I obviously read the abstracts for the papers, but I found myself also Googling other things after I read each of your abstracts. It was a rabbit hole of science, which was really exciting.                               I now want to transition to kind of a career angle. You all are obviously quite successful, scientifically, at the bench, right? But now you are pivoting to a kind of completely opposite slash new job, right? That of, independent researcher. I would love to hear from each of you, if there was any interesting challenge that you kind of overcame that you grew from, or if there was any bit of advice that you wish you knew ahead of time or anything like that, that some of our trainee listeners and actually frankly, faculty who can pass that information onto their trainees, can benefit from.   Anja Karlstaedt:          I think the biggest challenge for me in transitioning was actually the pandemic. Because I don't know how it was for Hisa and Matt, but trying to establish a lab, but also applying for faculty position during a major global pandemic, is challenging is not quite something that I expected that would happen. And so I think saying that and looking more conceptually and philosophically at this as, you can prepare as much as you want, but then when life just kicks in and things happen, they do happen. And I think the best is to prepare as much as you can. And then simply go with the flow. Sometimes one of my mentors, Dave Nikon, mentioned that to me when I was applying for faculty positions, it's sometimes good to just go with the flow. And as a metabolism person, I absolutely agree. And there are some things that you can do as a junior investigator.   Anja Karlstaedt:          We need to have a good network. So just very important to have good mentors. I was blessed with have those mentors, Peggy Goodell's one of them, Heinrich Taegtmeyer was another. And now with this study that we are publishing, Jim Martin and Dave Nikon were incredible. Without them, this study wouldn't have been possible and I would not be here at Cedars.   Anja Karlstaedt:          You need to reach out to other people because those mentors have the experience. They have been through some of this before. Even if they have never had a major event, like COVID-19 in their life before, because none of us had before, they had other experiences and you can rely on them and they set you then up for overcoming these challenges. And the other thing I would say, is put yourself out there, go and talk to as many people as possible or set conferences, present a poster, not only talks. Don't be disappointed if you don't get a talk, posters are really great to build this network and find other people that you probably wouldn't have encountered and apply for funding. Just again, put yourself out there and try to get the funding for your research. Even if it's small foundations, it builds up over time and it is a good practice to then write those more competitive grants.     Cindy St. Hilaire:        Dr Hashimoto, would you like to go next?   Hisayuki Hashimoto:   Just my advice is that, could be like a culture of difference, but in east Asia, like in Japan, we were taught to, do not disturb people, don't interrupt people and help people. But I realized that I wasn't really good at asking for help. After I am still not like fully independent, but I do have my own group and I have to do grant writing. I still work at the bench and then have to teach grad students, doing everything myself. I just realized it's just impossible. I didn't have time. I need like 48 hours a day. Otherwise, you won't finish it. I just realized that I wasn't really good at asking for help. So my advice would be, don't hesitate to ask for help. It's not a shame. You can't do everything by just yourself. I think, even from the postdoc, even from grad school, I think, ask for help and then get used to that. And then of course, help others. And that is the way I think to probably not get overwhelmed and not stress yourself. Science should be something fun. And if you don't ask for help and if you don't help someone, I think you are losing the chance of getting some fun part from the science.   Cindy St. Hilaire:        That's great advice. I really like that, especially because I find at least, I started my lab seven years ago now. And I remember the first couple months/year, it was extremely hard to let go, right? Like I taught my new people how to do the primary cell culture we needed, but I was terrified of them doing it wrong or wasting money or making too many mistakes. But you realize, you got to learn to trust people. Like you said, you got to learn to ask for help. And sometimes that help is letting them do it. And you doing, you're being paid now to write grants and papers. That's a big brain, you're not paid to do the smaller things. That's really great advice. I like that. Thank you. Dr DeBerge, how about you?   Matthew DeBerge:      So I guess towards a bit of life advice, I think two obvious things is one, be kind, science is hard enough as it is. So I think we should try to lift each other up and not knock each other down. And along those lines as the others have alluded to as well, one of the mantras we sort of adapted on the lab, is a rising tide raises all ships, this idea that we can work together to elevate each other's science and really, again, collaborate.   Towards the career side of things I'll just touch on, because I guess one thing I'll add, there's more than one path, I guess, to achieving your goals. I've been fortunate enough to have an NIH post-doctoral fellowship and had an AHA career development award, but I'm not a K99 recipient. Oftentimes, I think this is the golden ticket to getting the faculty job, so I'm trying to, I guess, buck trend, I just submitted an RO1. So fingers crossed that leads to some opportunity.   Even beyond academia, I'm not certain how much everyone here is involved in science Twitter, it's really become a thing over the last couple years, but I think, kind of the elephant in the room is that academia, it's really hard on the trainees nowadays to have a living wage, to go through this. I mean, I'm really excited to see my, fellow finalists here are starting their own groups and stuff, but for many, that's not the reality for many, it's just not financially feasible. So I think, kind of keeping in mind that there's many, many alternative careers, whether it's industry, whether it's consulting, science writing, etcetera, going back to what Dr Hash says, find what you love and really pursue that with passion.   Cindy St. Hilaire:        I think it's something only, I don't know, five to 10% of people go into or rather stay in academia. And that means, 90 to 95% of our trainees, we need to prepare them for other opportunities, which I think is exciting, because it means it can expand our network for those of us in academia.   Anja Karlstaedt:          I think right now it's even worse because it's about 2% of old postdocs that are actually staying and becoming independent researchers, independent or tenure track or research track. And I think I second, as what Matt said, because I play cello. I do music as a hobby and people always ask me if I'm a musician. And at the beginning I felt like, no, of course not. I'm not like Yoyo Ma. I'm just playing, it's a hobby. And then I, that got me thinking. I was like, no, of course you are because there's so many different types. And what we need to understand is that scientists, like you are always a scientist. It doesn't matter if you are working at Pfizer or if you are working at a small undergrad institution and you're teaching those next generation scientists, you are still scientist and we all need those different types of scientists because otherwise, if everybody is just a soloist, you are never going to listen to symphony. You need those different people and what we need to normalize beyond having those different career paths, is also that people are staying in academia and becoming those really incredible resources for the institutions and labs, quite frankly, of being able to retain those technologies and techniques within an institution. And I think that's something to also look forward to, that even if you're not the PI necessarily, you're the one who is driving those projects. And I hope to pass this on at some point also to my trainees that they can be a scientist, even if they're not running a lab and they become an Institute director and that's also critically important.   Cindy St. Hilaire:        There's lots of ways to do science. Thank you all so much for joining me today. Either waking up at 5:00 AM or staying up past midnight, I think it is now in Japan or close to it. So Matt and I kind of made it out okay. It's like 8:00 or 9:00 AM.   Matthew DeBerge:      Thank you.   Hisayuki Hashimoto:   My apologies for this time zone difference.   Cindy St. Hilaire:        I'm very glad to make it work. Congratulations to all of you, your presentations. I forget which day of the week they are on at BCVS, but we are looking forward to the oral presentations of these and congratulations to all of you. You are amazing scientists and I know I'm really looking forward to seeing your future work so best of luck.   Matthew DeBerge:      Thank you.   Hisayuki Hashimoto:   Thank you.   Anja Karlstaedt:          Thank you so much.   Cindy St. Hilaire:        That's it for the highlights from the June 24th, July 8th and July 22nd issues of Circulation Research. Thank you for listening. Please check out the CircRes Facebook page and follow us on Twitter and Instagram with the handle at CircRes and hashtag Discover CircRes. Thank you to our guests. The BCVS Outstanding Early Career Investigator Award Finalists, Dr Hisayuki Hashimoto, Dr Matthew DeBerge and Dr Anja Karlstaedt. This podcast is produced by Ashara Ratnayaka, edited by Melissa Stoner and supported by the editorial team of Circulation Research. Some of the copy text for the highlighted articles is provided by Ruth Williams. I'm your host, Dr Cindy St. Hilaire. And this is Discover CircRes, you're on the go source for the most exciting discoveries in basic cardiovascular research. This program is copyright of the American Heart Association, 2022. The opinions expressed by speakers in this podcast are their own and not necessarily those of the editors or of the American Heart Association. For more information visit ahajournals.org.  

Late Confirmation by CoinDesk
THE HASH: 7 Korean Exchanges Reportedly Raided Amid Terra Probe and a Startup Uses AI to Authenticate NFTs

Late Confirmation by CoinDesk

Play Episode Listen Later Jul 20, 2022 27:32 Very Popular


The most valuable crypto stories for Wednesday, July 20, 2022."The Hash" team discusses the top stories of the day, including a report that seven cryptocurrency exchanges in South Korea have been raided by prosecutors probing a fraud case in connection with the collapse of terraUSD (UST) and LUNA. Plus, a closer look at a startup using artificial intelligence to authenticate non-fungible tokens (NFT).This episode was edited by Eleanor Pahl and our executive producer is Jared Schwartz. Our theme song is “Neon Beach.”See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Talk Energy
#133: Hash Bender

Talk Energy

Play Episode Listen Later Jul 20, 2022 68:42


This episode's guest is Nick Hanson the CEO & co-founder of Luxor. Nick started the company with a bootstrapped business model back in 2017 and has grown Luxor into one of the more recognizable brands in Bitcoin mining and analytics. This episode we talk about Nick's views on the intersection between energy and Bitcoin mining. We discuss the 3-part series he is writing about energy. He gives the history of Luxor and the vision for the company into the future. Lastly, we talk about how Bitcoin mining is incentivizing innovations in the energy industry and will play a critical role in how power providers and energy producers think about the future of energy. Hope you enjoy the show! Talk.Energy Podcast: https://talk.energy/ Twitter: https://twitter.com/max_gagliardi Twitter: https://twitter.com/talkenergypod LinkedIn: https://www.linkedin.com/company/talkenergy YouTube: https://www.youtube.com/c/TalkEnergyPodcast Blockware Solutions' Twitter: https://twitter.com/BlockwareTeam Are you looking to mine Bitcoin? Mining is the best way to dollar cost average into Bitcoin at a discount. Blockware Solutions offers new and used mining rigs from leading manufacturers with an optional turnkey hosting package. With Bitcoin mining experience dating back to 2013, Blockware Solutions has sold over 250,000 ASICs, hosted 200+ MW of clients, and mined thousands of BTC from the Blockware Mining Pool.

Late Confirmation by CoinDesk
THE HASH: Report Reveals Behind-the-Scenes Concerns at Crypto Lender Celsius, Dubai Unveils Metaverse Strategy

Late Confirmation by CoinDesk

Play Episode Listen Later Jul 19, 2022 29:23 Very Popular


The most valuable crypto stories for Tuesday, July 19, 2022.Former Celsius Network employees reveal internal concerns with the company in a new report from CNBC. The investigation details some of the firm's alleged missteps years before it filed for bankruptcy. "The Hash" hosts discuss the latest headlines surrounding Celsius and crypto hedge fund Three Arrows Capital. Plus, a look at Dubai's bet in becoming one of the world's top 10 metaverse economies.This episode was edited by Eleanor Pahl and our executive producer is Jared Schwartz. Our theme song is “Neon Beach.”See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Brutal Vulnerability
Vodka, Cocaine, & Women's Clothing W/ Kenneth Hash & James St. James

Brutal Vulnerability

Play Episode Listen Later Jul 19, 2022 74:47


Two of the original influencers, Kenneth Hash (partygay turned tinsel town costumer) & James St James (the first celebutante turned author turned producer) join Rebecca & Lauren to discuss the Original Club Kids as they pertain to the theme of belonging and the courage to be fully who you are. The audacity to spread joy during the AIDS crisis, finding your tribe, a land before cell phones, and when the party truly does not start until you walk in. James is the author of Disco Bloodbath, the book from which the film Party Monster starring MaCauley Culkin is based. Lauren discovered both book and movie as an angsty teen & the pure relief of knowing that somewhere, there was a place she would belong. More on this era of Lauren's adolescence on ($5/month for personal video episodes on each episode, access to our instagram close friends list, yoga, and more on) Patreon!  Instas: @jamesstjames1 @kennethhash @brutalvulnerability Please review the pod if you've a moment & enjoyed listening! XOXO

Late Confirmation by CoinDesk
THE HASH: What's Next for Celsius Customers; Crypto VC Investments Drop 26% in First Half of 2022

Late Confirmation by CoinDesk

Play Episode Listen Later Jul 18, 2022 26:21 Very Popular


The most valuable crypto stories for Monday, July 18, 2022."The Hash" team discusses today's top stories, including Celsius Network outlining its next steps as the insolvent crypto lender's bankruptcy hearing starts. Plus, a closer look at venture capital (VC) investments in crypto companies, as funding drops 26% in the first half of the year.This episode was edited by Eleanor Pahl and our executive producer is Jared Schwartz. Our theme song is “Neon Beach.”See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Those Guys From Wichita
Conradio Presents: Melissa Wedman (Molly Coddled Hash Slinger)

Those Guys From Wichita

Play Episode Listen Later Jul 18, 2022 36:22


We are joined by the owner of Molly Coddled Hash Slinger in OKC. Melissa Wedman. Melissa takes us through her story of being a food blogger, to becoming the owner of the coolest named Carmel shop in Oklahoma. We talk the best part of owning your own business and on the flip side some of the struggles that come with it. We find out that she is married to a Yukon Oklahoma drug dealer... (pharmacist), who doesn't wear a lab coat, but does drink coffee and listen to Joe Rogan, and that every once in a while you have to pinch a Toblerone or have a drunk Taco Bell run. Her treats are available nationwide and can be found here: www.mollycoddledhashslinger.net or stay in touch with the shop's social media: www.instagram.com/mollycoddledhashslinger www.Facebook.com/mollycoddledhashslinger Subscribe to Conradio for free here on Youtube or: Apple Podcast: https://podcasts.apple.com/us/podcast/conradio/id772967885 Spotify: https://open.spotify.com/show/7InK6IzBqK3KVK2uSHkLdA?si=97ea8f1be2634786 Support the show by visiting our Patreon www.patreon.com/conradio Connect With us on Social Media: www.Facebook.com/conradio www.Instgram.com/conradio_show https://twitter.com/conradioshow Website: https://www.oktacocompany.com/podcasts  

It Came From The Radio
71822-Syndicated-RayFelix

It Came From The Radio

Play Episode Listen Later Jul 18, 2022 53:44


Mark, Fishy Sarcasm's Dominic Sparano, Senior Correspondent Charlie Saladino and Jenny Feldy discuss the news, a new Jaybird and Lee segment, at the Cradle Con Jen interviews EVO Comic's Hash and Comic Creator Ray Felix

West Coast Cookbook & Speakeasy
West Coast Cookbook and Speakeasy - River City Hash Mondays 18 July 22fa

West Coast Cookbook & Speakeasy

Play Episode Listen Later Jul 18, 2022 63:49


West Coast Cookbook & Speakeasy is Now Open! 8am-9am PT/ 11am-Noon ET for our especially special Daily Specials; River City Hash Mondays!Starting off in the Bistro Cafe, Kinzinger says the J6 Committee has "filled in the blanks" and this week's hearing will “open people's eyes in a big way.”Then, on the rest of the menu, Maryland Dems are eager to break the Republican stranglehold on the governor's office; a survey of state election officials across the US found the expanded use of drop boxes for mailed ballots during the 2020 election did not lead to any widespread problems; and, a state-chartered bailout fund is seeking to borrow $600 million after seven Louisiana insurers went bust following 2021′s Hurricane Ida.After the break, we move to the Chef's Table where Thai pro-democracy activists had their cell phones or other devices infected and attacked with government-sponsored Pegasus spyware; and, French holocaust survivors marked eighty years since the mass Paris roundup.All that and more, on West Coast Cookbook & Speakeasy with Chef de Cuisine Justice Putnam.Bon Appétit!~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~"I was never a spy. I was with the OSS organization. We had a number of women, but we were all office help." -- Julia Child~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~Show Notes & Links:https://www.dailykos.com/stories/2022/7/18/2110977/-West-Coast-Cookbook-amp-Speakeasy-Daily-Special-River-City-Hash-Mondays

Late Confirmation by CoinDesk
THE HASH: Hash Headlines – Top Stories of the Week

Late Confirmation by CoinDesk

Play Episode Listen Later Jul 16, 2022 35:30 Very Popular


A roundup of the week's most valuable crypto stories for Saturday, July 16, 2022.Missed any episodes of “The Hash” this week? Today's recap episode will get you caught up.“Hash Headlines” rounds up this week's headline stories, including:Fans of the National Basketball Association's Dallas Mavericks calling out owner Mark Cuban over a partnership with bankrupt crypto platform Voyager Digital.The latest court order regarding Three Arrows Capital.U.S. inflation hits fresh 40-year high at 9.1% in June.Celsius Network co-founder and CEO Alex Mashinsky responding to the crypto lender filing for bankruptcy protection.Celsius owed $439 million by Indianapolis-based private lending platform EquitiesFirst, according to the Financial Times.This episode was edited by Michele Musso and Eleanor Pahl and our executive producer is Jared Schwartz. Our theme song is “Neon Beach.”See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Late Confirmation by CoinDesk
THE HASH: Celsius Network Reportedly Owed $439M by Lending Firm EquitiesFirst, South Park Movie Mocks Celebrity Crypto Endorsement

Late Confirmation by CoinDesk

Play Episode Listen Later Jul 15, 2022 28:15 Very Popular


The most valuable crypto stories for Friday, July 15, 2022.Beleaguered crypto lending firm Celsius Network is owed $439 million by Indianapolis-based private lending platform EquitiesFirst, according to the Financial Times. This comes as Celsius' first bankruptcy case hearing is expected to take place on Monday. "The Hash" team discusses this developing story. Plus, what does the latest “South Park” movie have to do with crypto?This episode was edited by Eleanor Pahl and our executive producer is Jared Schwartz. Our theme song is “Neon Beach.”See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Good Risings
60.5. Hash It Out: Come As You Are - Mismatched Libidos

Good Risings

Play Episode Listen Later Jul 15, 2022 5:34


Good Risings is a mindset. Join Elizabeth Earnshaw for a daily dose of Advice. Presented By: Cavalry Audio.  Producers: Jason Seagraves & Margot Carmichael.     Audio Editing: Revision Sound. Music: Gramoscope Music.  Executive Producers: Elizabeth Earnshaw, Dana Brunetti & Keegan Rosenberger.  You can now search all of the Good Risings episodes on Fathom.fm/GoodRisings! See omnystudio.com/listener for privacy information.

Good Risings
60.4. Hash It Out: Getting Over a Crush

Good Risings

Play Episode Listen Later Jul 14, 2022 4:17


Good Risings is a mindset. Join Elizabeth Earnshaw for a daily dose of Advice. Presented By: Cavalry Audio.  Producers: Jason Seagraves & Margot Carmichael.     Audio Editing: Revision Sound. Music: Gramoscope Music.  Executive Producers: Elizabeth Earnshaw, Dana Brunetti & Keegan Rosenberger.  You can now search all of the Good Risings episodes on Fathom.fm/GoodRisings! See omnystudio.com/listener for privacy information.

Late Confirmation by CoinDesk
THE HASH: Celsius Network CEO Says Bankruptcy Filing 'the Right Decision' and Polygon Joins Disney's Accelerator Program

Late Confirmation by CoinDesk

Play Episode Listen Later Jul 14, 2022 28:20


The most valuable crypto stories for Thursday, July 14, 2022."The Hash" team discusses Celsius Network co-founder and CEO Alex Mashinsky responding to the crypto lender filing for bankruptcy protection by noting in a press release that it's the "right decision for our community and company.” Plus, Disney's latest push into the metaverse.This episode was edited by Michele Musso and our executive producer is Jared Schwartz. Our theme song is “Neon Beach.”See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Good Risings
60.3. Hash It Out: Betrayal with Lacking Emotion

Good Risings

Play Episode Listen Later Jul 13, 2022 4:33


Good Risings is a mindset. Join Elizabeth Earnshaw for a daily dose of Advice. Presented By: Cavalry Audio.  Producers: Jason Seagraves & Margot Carmichael.     Audio Editing: Revision Sound. Music: Gramoscope Music.  Executive Producers: Elizabeth Earnshaw, Dana Brunetti & Keegan Rosenberger.  You can now search all of the Good Risings episodes on Fathom.fm/GoodRisings! See omnystudio.com/listener for privacy information.

Late Confirmation by CoinDesk
THE HASH: Charlie Munger Calls Crypto an ‘Investment in Nothing,' and Tony Hawk Enters the Metaverse

Late Confirmation by CoinDesk

Play Episode Listen Later Jul 13, 2022 28:54


The most valuable crypto stories for Wednesday, July 13, 2022.In an interview with the Australian Financial Review, billionaire investor Charlie Munger calls crypto an "investment in nothing." Plus, famed skateboarder Tony Hawk heads to the metaverse with a skatepark and 3D avatar collection in The Sandbox. Those stories and more on "The Hash."This episode was edited by Michele Musso and our executive producer is Jared Schwartz. Our theme song is “Neon Beach.”See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Late Confirmation by CoinDesk
THE HASH: Three Arrows Creditors Get Emergency Hearing and GameStop's NFT Marketplace Goes Live

Late Confirmation by CoinDesk

Play Episode Listen Later Jul 12, 2022 26:08 Very Popular


The most valuable crypto stories for Tuesday, July 12, 2022."The Hash" team discusses the latest court order regarding Three Arrows Capital, GameStop's NFT marketplace and more.This episode was edited by Michele Musso and our executive producer is Jared Schwartz. Our theme song is “Neon Beach.”See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Good Risings
60.2. Hash It Out: The Break-Up Conversation

Good Risings

Play Episode