Podcasts about Pags

A tragic mass shooting unfolded today during a school-wide Mass at Annunciation Catholic School in Minneapolis. Two children—ages 8 and 10—were killed, and 17 others were wounded, including 14 students and three elderly parishioners. Pags brings the hard-hitting analysis that media avoids—understanding motives, questioning school security, and demanding accountability. It's gut-punching, necessary coverage you won't want to miss. Learn more about your ad choices. Visit megaphone.fm/adchoices

Pags opens the hour with the latest on the horrific shooting at Annunciation Catholic School in Minneapolis — two children killed and 17 more wounded, in what investigators are calling a possible hate crime against Catholics. Joe breaks down the unanswered questions, the failures in prevention, and what the mainstream media is leaving out. Then, Liz Collin of Alpha News joins with powerful reporting you won't hear anywhere else. She brings new details on the attack, explains how weak leadership in Minnesota is making communities less safe, and lays out why radical ideology is gripping the city. It's a fact-driven, no-spin hour you can't miss. Learn more about your ad choices. Visit megaphone.fm/adchoices

Pags kicks off with wallet-friendly news: Labor Day gas prices are projected to be the lowest in five years (around $3.15/gal on average), and he explains why it's happening now. Then he breaks down President Trump's push to consider RICO against George Soros and his son—what that would mean legally and politically. To cap the hour, USCIS Director Joseph B. Edlow joins to clarify how citizenship works in practice: eligibility vetting, when green cards can be revoked, and what a real pathway to citizenship looks like, straight from the agency that runs the system. Learn more about your ad choices. Visit megaphone.fm/adchoices

Big news as Steve Friend and Garret O'Boyle are reinstated in the FBI — a huge win for accountability and the rule of law, and Pags is cheering the move. Then, the show turns to a fiery debate: should Washington, D.C. bring back capital punishment for murders in the capital? Pags breaks it all down and opens the lines to callers across America for their take. It's an action-packed hour of news, opinion, and real voices you won't want to miss. Learn more about your ad choices. Visit megaphone.fm/adchoices

Pags dives into a fun conversation on old movies that could never be made today — is comedy changing for good, or is there still hope for fearless humor? Then, actor and filmmaker Dean Cain joins the show after his big announcement of joining ICE. Cain walks Pags through the agent training course he completed, what he experienced firsthand, and why he took on the challenge. It's a mix of laughs, nostalgia, and a fascinating look behind the scenes you won't want to miss. Learn more about your ad choices. Visit megaphone.fm/adchoices

Pags kicks off with the story lighting up headlines everywhere — Taylor Swift is engaged! But engaged to who? Joe has some fun with the biggest pop-culture news in the world. Then, he shifts gears to politics and breaks down President Trump's surprising approval for 600,000 Chinese students to study in America — what it means, and why it has people asking serious questions. Finally, Brent Sadler from The Heritage Foundation joins Pags for a full-throated conversation on the biggest issues across the globe — Russia and Ukraine, Gaza and Israel, China, India, energy policy, and whether our Navy is truly prepared for the challenges ahead. It's a fast, fiery hour you won't want to miss. Learn more about your ad choices. Visit megaphone.fm/adchoices

Pags has the latest update as Killmar Abrego Garcia is arrested by ICE yet again — and this time the details will leave you shaking your head. Then, Pags turns to the bigger picture: what is the Democratic Party really showing right now? Strength, or a whole lot of weakness? He breaks it down with the straight talk and sharp analysis you count on. Learn more about your ad choices. Visit megaphone.fm/adchoices

Pags breaks down an urgent question: can President Trump really send the National Guard anywhere, for any reason? The answer is no — and Joe explains why those limits matter for state sovereignty, safety, and the fight over America's crime crisis. Then, Rep. Laurel Lee of Florida joins the show to weigh in on crime in D.C., why she supports the “Alligator Alcatraz Act,” the debate over safety measures like body cams for lawmakers, and the latest House probe into the Democrats' primary fundraising machine. It's a packed hour of straight talk and sharp insight you can't miss. Learn more about your ad choices. Visit megaphone.fm/adchoices

Pags breaks down President Trump's wave of executive orders — including a fiery one banning flag burning, a direct challenge to the Supreme Court's recent ruling protecting it under free speech. Joe explains why he disagrees with the premise, but finds himself nodding at the president's own wording. Then, Kay Hill joins the show for a lively conversation on the return of American masculinity — from leaders setting the tone to everyday people getting back in shape. Plus, an update on the Cracker Barrel debate, and a must-hear story of a North Carolina mom in Italy whose purse was stolen — and her unforgettable “mom mode” reaction that's inspiring. Learn more about your ad choices. Visit megaphone.fm/adchoices

California thought they could clap back at Texas with their own redistricting scheme — but Pags reveals why the plan is already falling apart. Then, buckle up: retired police Major Travis Yates joins Pags for a jaw-dropping interview. From Maricopa County to D.C., Yates exposes how past DOJ administrations cooked the crime numbers, hiding the truth from the American people. He's trained cops nationwide, he's got the receipts, and he's not holding back. This explosive uncovering will leave you stunned — and you won't hear it anywhere else. Learn more about your ad choices. Visit megaphone.fm/adchoices

President Trump scores a major legal win as a New York appeals court tosses out Attorney General Letitia James' massive $500 million civil fraud penalty, ruling the fine was unconstitutional under the Eighth Amendment. Pags breaks down what this means for Trump moving forward. Then, all eyes turn to Gavin Newsom — is he quietly positioning for a presidential run? Pags tears into Newsom's latest moves and delivers a fiery takedown you have to hear. Learn more about your ad choices. Visit megaphone.fm/adchoices

Did Cracker Barrel really go woke? Some conservative commentators say yes — but Pags isn't so sure. In a lively debate on rebranding and business, Joe delivers a life lesson for anyone thinking about chasing trends: not so fast! Then, Congressman Chip Roy drops big news — he's not running for reelection to Congress. Instead, he's going home to Texas and running for Attorney General. Roy joins Pags to explain why he's leaving D.C., what pulled him back to Texas full-time, and why he believes the fight for America's future starts in the Lone Star State. Learn more about your ad choices. Visit megaphone.fm/adchoices

Pags and Polo go head-to-head in a fiery debate over Trump's plan to paint the border wall black — who do you agree with? Then, breaking news out of Texas as lawmakers vote to pass new redistricting maps with major political fallout. And Stephen Miller pulls no punches on protecting Americans, backing the National Guard's move into D.C. to restore order. It's a packed hour of arguments, analysis, and straight talk you won't want to miss. Learn more about your ad choices. Visit megaphone.fm/adchoices

The Joe Pags Show is on fire this hour! VP J.D. Vance, Pete Hegseth, and Stephen Miller hit Union Station in D.C. to stand with the National Guard — and face off with protestors. One heckler tried to shout them down, and Vance's quick quip had the crowd buzzing. Then, Senator Eric Schmitt joins Pags for a no-holds-barred conversation about his new book The Last Line of Defense. They dig into Article III, who's going to pay for the Russiagate hoax, and why his book is the ultimate guide for crushing the left's machine. It's sharp, it's fun, and it's everything you tune in for. Learn more about your ad choices. Visit megaphone.fm/adchoices

It's a spit-fire news hour on the Joe Pags Show! First, we remember Judge Frank Caprio — the viral “kind judge” whose heartfelt courtroom clips touched millions — after news of his passing. Then, Pags dives into a wild lawsuit: an airline passenger is suing for buying a “window seat” that didn't actually have a window. Frivolous or justified? The staff weighs in with hilarious hot takes. And finally, Joe Pags sits down with Matt Bowyer — the man who pled guilty in a massive sports betting scandal tied to Shohei Ohtani's translator. Bowyer opens up about taking millions in bets, facing prison time, and his new book Recalibrate. From gambling to motivation to prison walls, this is one story you can't miss. Learn more about your ad choices. Visit megaphone.fm/adchoices

Pags is all over MSNBC's split from NBC — and their new name “MS Now” is such a disaster the staff can't stop laughing. Then, Tulsi Gabbard drops a political bombshell by yanking security clearances from nearly 40 former officials. Who's on that explosive list? Pags breaks it down name by name. And Karoline Leavitt shocks the press by torching clueless pundits live. One hour of laughs, fire, and facts you won't get anywhere else. Learn more about your ad choices. Visit megaphone.fm/adchoices

Breaking news out of Texas — a Democrat lawmaker is making headlines for literally sleeping inside the state Capitol, but even her protest hit pause after a reported active shooter threat forced an evacuation. Pags breaks it all down live. Plus, the State Department just revoked thousands of visas, including cases tied to crime and even terror concerns — Pags explains why it matters. And Rep. Randy Fine of Florida joins to talk about his new bill that would ensure the U.S. Census counts only citizens and legal residents, a move he says is simple common sense. Learn more about your ad choices. Visit megaphone.fm/adchoices

Boston Mayor Michelle Wu delivers a head-scratching speech where she defends protections for illegal immigrants while leaving American citizens behind. Pags breaks it down as nothing more than political word salad. Then, former Capitol Police Chief Steven Sund joins to set the record straight on January 6. A 25-year DC policing veteran, Sund reveals how Pelosi tried to pin the chaos on him — but he's now pushing back with receipts. An important hour of facts, context, and candor you won't see elsewhere. Learn more about your ad choices. Visit megaphone.fm/adchoices

It's a packed day of breaking news! President Trump met with Zelenskyy and top NATO leaders in Washington, pushing bold new security guarantees for Ukraine instead of full NATO membership, while setting the stage for a potential Trump-Putin-Zelenskyy summit that could redefine peace talks. Meanwhile, in Texas, Democrats have finally decided to return after their stunt of fleeing the state—but Pags isn't letting them off the hook. Their walkout cost taxpayers big money, and the question remains: will they still be forced to pay their daily fines? Don't miss Pags' fiery breakdown of international diplomacy colliding with political games at home. Learn more about your ad choices. Visit megaphone.fm/adchoices

Revved-up Rumblings and Fit Foretelling! Tune in with Pags for a hysterical breakdown of today's “How Not to Drive” comedy — because let's face it, American drivers are a national spectacle. Then, hold on tight: are cell phones finally being banned in classrooms? Pags dives into that debate head-first. But don't look away — Pags also spotted RFK Jr. and Pete Hegseth going rep for rep in an unforgettable Pentagon push-up/pull-up showdown that might just be the start of Make America Healthy Again taking off. Kay Hill joins Pags with the inside scoop: she grew up in Europe, now lives here in the States, and delivers her unique perspective on why the Presidential Fitness Test is back — and how Europe views Trump's explosive summit with Zelenskyy and NATO. Learn more about your ad choices. Visit megaphone.fm/adchoices

Pags dives into the explosive meetings in Washington where President Trump hosted NATO leaders and Ukrainian President Volodymyr Zelenskyy. What really went down behind closed doors? Later, Victoria Coates joins the show to explain what these high-stakes talks mean for America's future — from our security to our role on the world stage. A power-packed hour of news and entertainment you can't miss! Learn more about your ad choices. Visit megaphone.fm/adchoices

President Trump and Vladimir Putin shocked the world with a joint press conference announcing they've reached an understanding — and Pags breaks down the raw audio in real time, cutting through the spin with expert analysis on what it means for global peace. Then, House Judiciary Chair Jim Jordan joins Pags for a fiery interview, torching “auto-pen pardons,” demanding stronger police protection in D.C., and blasting the left for crying foul while refusing to stop crime. One electric hour of history, hard truths, and no-nonsense talk you can't miss! Learn more about your ad choices. Visit megaphone.fm/adchoices

Pags breaks down the historic Alaska meeting with the hard facts the media won't give you. Then, Kash Patel slams DC's failed policies and scorches local leaders in a fiery take. And don't miss Pags' in-studio sit-down with Rep. Tony Gonzales—two Texas patriots pulling no punches as they expose Democrat failures, the state of the border under Trump, and the truth about crime in DC. A must-hear conversation packed with fire and facts. Learn more about your ad choices. Visit megaphone.fm/adchoices

It's a historic day — President Trump and Russian President Vladimir Putin are set to meet in Alaska, and Pags is locked in with fiery predictions and sharp analysis. Will the two leaders strike an understanding? What's really at stake for America and the world? For an entire electric hour, Pags takes you through the tension, the possibilities, and the political chess game unfolding in real time. Then — just as the waiting builds to its peak — the two presidents finally walk out. This is one of those moments you'll never forget, and one thrilling hour of radio you simply cannot miss! Learn more about your ad choices. Visit megaphone.fm/adchoices

POTUS Trump calls in the National Guard to restore order in Washington, D.C., and Pags isn't holding back. He digs up a throwback of Karine Jean-Pierre from the “auto-pen/Harris” days, exposing the administration's weak stance on crime. From D.C. to Chicago, liberal leaders have let chaos thrive while spinning empty sound bites to protect their image. Pags calls it out, names names, and shreds the soft-on-crime agenda that's been failing Americans for far too long. This fiery breakdown will have you shaking your head — and cheering for real leadership. Learn more about your ad choices. Visit megaphone.fm/adchoices

On the 90th anniversary of Social Security, President Trump pledges to strengthen the program for all Americans — especially our seniors. Pags breaks down the history, why it matters, and what changes could be coming. Then, Senator Markwayne Mullin joins for a no-holds-barred conversation on skyrocketing crime in D.C., the push to federalize the police, and tomorrow's high-stakes sit-down with Putin in Alaska. They dive into the role of the BBB in keeping America safe and why decisive leadership is critical right now. This one's packed with history, policy, and hard truths you need to hear. Learn more about your ad choices. Visit megaphone.fm/adchoices

President Vladimir Putin has touched down in Alaska ahead of his historic meeting with President Trump — and Pags is breaking down the significance of this high-stakes moment. Meanwhile, California Governor Gavin Newsom is busy taking shots at Trump instead of fixing his state's spiraling crime and homelessness. Is he angling for higher office? Pags digs into the political gamesmanship. PLUS — Florida Attorney General James Uthmeier joins Pags for a fiery conversation about the uproar over “Alligator Alcatraz,” media lies about immigration facilities, and Governor Ron DeSantis' new Deportation Depot. Uthmeier lays out Florida's tough-on-crime approach and their plan to deport dangerous criminals to keep Americans safe. Learn more about your ad choices. Visit megaphone.fm/adchoices

Joe Pags takes you through a whirlwind of today's biggest headlines—from Melania Trump suing Hunter Biden to President Trump's upcoming meeting with Russian President Vladimir Putin this Friday. Pags gives you the straight truth, cutting through the noise and delivering the facts you need. Then, Dr. Jesse Lopez joins the show to reveal jaw-dropping details about the Department of Health and Human Services, including his claim that 73% of FDA-approved medications may not actually work for their intended purpose. You won't want to miss this explosive mix of politics, global news, and hard-hitting medical revelations. Learn more about your ad choices. Visit megaphone.fm/adchoices

A DC police commissioner is accused of manipulating crime statistics—sparking outrage and prompting President Trump to call in the National Guard to help restore order in the nation's capital. While the left cries foul, Joe Pags breaks down why this move could be exactly what DC needs to get safer streets. From political spin to hard facts, Pags asks the tough question—who actually benefits from higher crime? The answer may shock you. Learn more about your ad choices. Visit megaphone.fm/adchoices

Joe Pags kicks things off with a fun dive into a new social media feature that lets you see exactly who's liking your content—and the surprise celebrity who enjoys his conservative takes. Then, things turn serious as Texas AG Ken Paxton joins the show to break down the latest stunt from Texas Democrats, who were supposedly coming back… but now aren't. Paxton lays out why he wants charges brought against Beto O'Rourke, how this could lead to changes in quorum rules, and who's responsible for making sure lawmakers pay the $500-a-day fines. Plus—can other states follow Texas in redistricting? And what's this settlement with Kellogg's all about? Pags and Paxton cover it all. Learn more about your ad choices. Visit megaphone.fm/adchoices

Joe Pags rips into Texas Democrats still dodging redistricting votes—hoping the $500-a-day fines actually stick and these lawmakers finally face real consequences for their shameless obstruction. Could this be the political purge Texas has been waiting for? Then, former EPA Chief of Staff Mandy Gunasekara joins Pags to deliver an unfiltered takedown of the “Green New Scam.” As the author of Y'all Fired, she breaks down the true cost of overzealous environmental policies, why bringing manufacturing back to America is essential, and how energy independence can secure our future. This is a must-hear powerhouse interview! Learn more about your ad choices. Visit megaphone.fm/adchoices

Joe Pags breaks down the truth behind President Trump's move to bring the National Guard to Washington, D.C.—and why it's nothing like the left's fearmongering headlines suggest. From rising crime rates to the real constitutional authority at play, Pags cuts through the spin to show why this decision makes sense. Plus, Press Secretary Karoline Leavitt reveals shocking crime stats and explain why bringing in more law enforcement isn't just legal—it's the right move to protect Americans. This is a conversation you won't hear anywhere else. Learn more about your ad choices. Visit megaphone.fm/adchoices

Major League Baseball just made headlines with its first female umpire—and while Pags says “who cares,” he admits there's one surprising reason hedoes care, and you'll want to hear it. Then, Kay Hill joins the show for a sharp, engaging discussion as President Trump considers the legality of marijuana. From federal law to state policy battles, Kay brings her insight to a debate that's heating up fast. This hour delivers sports, politics, and a whole lot of unexpected perspective. Learn more about your ad choices. Visit megaphone.fm/adchoices

Texas Democrats remain out of state, refusing to return and break the GOP's redistricting push, and Pags has the latest on where they are—and what's next. Meanwhile, President Trump has authorized the deployment of the National Guard to assist DC police as violent crime spikes in the capital. The move has the left in an uproar, but Pags breaks down why this decision could reshape the conversation on law and order in America's cities. An hour packed with political drama, real-time updates, and sharp analysis you won't hear anywhere else. Learn more about your ad choices. Visit megaphone.fm/adchoices

Ghislaine Maxwell knows Epstein's darkest secrets—so why can't we hear from her? Pags digs into sealed filings, explains why a judge is blocking releases (yes, the “Obama judge” question gets answered), and does live fact‑checks on the rumor mill so you know what's real and what's spin. Then he pivots to a lightning‑rod topic: is gay marriage actually on the chopping block at the Supreme Court? Pags breaks down what's on the docket, what would have to happen to revisit precedent, and why his take might shock you. It's fiery, clear, and loaded with receipts—exactly why you can trust Joe Pags. Learn more about your ad choices. Visit megaphone.fm/adchoices

Joe Pags blasts through a rapid-fire news hour—California's response to Texas Democrats on the run, to Texas AG Ken Paxton's major court victory! Then, author and filmmaker Salvador Litvak joins to discuss his hit film Guns and Moses, so popular it's headed back to theaters. From Israel's challenges to the rise of antisemitism, Litvak delivers a fascinating, insightful conversation you won't forget. Learn more about your ad choices. Visit megaphone.fm/adchoices

Joe Pags breaks down exactly what a RICO case is—in plain, no-nonsense terms—and why he thinks the Russia-gate hoax could be a textbook example. Then, he pivots to Texas politics, giving the latest update on the runaway Democrats who fled the state to avoid doing their jobs. Who's come back so far? Spoiler: not a single one. Pags calls it like it is, exposing the political theater and the real consequences for Texans left waiting. Learn more about your ad choices. Visit megaphone.fm/adchoices

The UK is actually pushing to let 16-year-olds vote—and Pags isn't holding back! He rips into why handing the ballot box to teenagers is a disaster waiting to happen, then throws it to YOU: would you trust high school sophomores with America's future? And buckle up—Assistant AG Harmeet Dhillon steps in and absolutely unloads on the runaway Texas Democrats, exposes why the AG is 100% right, and warns that even deep-blue states may be forced to change their maps. It's fiery, it's funny, and it's the kind of hour you'll be talking about all week. Learn more about your ad choices. Visit megaphone.fm/adchoices

Joe Pags tackles two explosive stories in this can't-miss hour. First up, is Superman now an ICE agent? Dean Cain claims he's in—Pags breaks down the viral twist and what DHS Secretary Kristi Noem's change in ICE policy really means. Then, attorney Tom Renz joins the show with shocking insights into the mRNA vaccine rollout, government overreach, and how he stood before SCOTUS to fight back. He risked it all—and he's not done yet. You won't hear this anywhere else. Learn more about your ad choices. Visit megaphone.fm/adchoices

Governor Greg Abbott joins Joe Pags for a powerful live interview about Texas' redistricting plan—why it's legal, why it's happening now, and how the left is melting down despite doing the same for decades. Meanwhile, Maine's governor is threatening to redraw lines in an already deeply gerrymandered state where Republicans have zero real representation. Pags dives into the hypocrisy, the headlines, and what this power play means for 2026 and beyond. Don't miss this jam-packed hour full of facts the legacy media won't touch. Learn more about your ad choices. Visit megaphone.fm/adchoices

Pags unpacks a major update in the Russia-Ukraine conflict as Sen. Marco Rubio confirms White House negotiations with Russia are set to begin this week. But while international tension heats up, the real war may be on the home front—Rep. Burgess Owens joins Pags to expose the ongoing fight for America's students. From student loan forgiveness to school choice and the latest on the Big Beautiful Bill (BBB), Owens reveals how the education committee is pushing back against radical overreach. An interview filled with facts, fire, and the future of our children's education. Learn more about your ad choices. Visit megaphone.fm/adchoices

Pags dives into a double-header you won't want to miss—DNI Tulsi Gabbard exposes shocking new revelations about the DOJ's demands in the Russia hoax fallout, raising serious questions about accountability and justice. Then, former model and commentator Kay Hill joins Pags to break down the viral Sydney Sweeney controversy—what really happened, and why the media meltdown says more about Hollywood than her. This is one juicy, headline-ripping hour! Learn more about your ad choices. Visit megaphone.fm/adchoices

Al Green is once again calling for Trump's impeachment—yawn. Joe Pags isn't letting this nonsense slide. He exposes how the left is obsessed with everything except helping the American people. Plus, Rep. Tim Burchett joins Pags to slam the Texas Dems for fleeing the state and gives his raw, no-holds-barred take on their cowardice. Oh—and did someone say a new Pags parody is on the way? Stay tuned. Learn more about your ad choices. Visit megaphone.fm/adchoices

Joe Pags breaks down how congressional representation actually works—revealing how the left has been gerrymandering for decades while crying foul the moment Republicans follow suit. Broadcasting straight from his Texas studio—where redistricting is the hot topic—Pags exposes the double standard, the hypocrisy, and the centuries-old game Democrats have mastered. So why play victim now? Pags lays it all out with clarity, facts, and a whole lot of common sense. Learn more about your ad choices. Visit megaphone.fm/adchoices

Is the U.S. preparing to put nuclear energy on the moon? Pags breaks down a wild new proposal from Secretary Sean Duffy and dives deep into the real energy conversation with Daniel Turner, founder of Power the Future—a leading voice on American energy independence. Turner exposes surprising truths about carbon levels today vs the dinosaur era, outlines the new LNG trade deal with the EU, and explains why the Green Agenda is putting America at risk. From nuclear power to natural gas, this interview covers the future of energy like you've never heard before. Learn more about your ad choices. Visit megaphone.fm/adchoices

Texas Democrats are on the run—literally. Legislators fled the state to avoid a perfectly legal redistricting vote… and now New York's Kathy Hochul is weighing in? Joe Pags breaks down why this is business as usual for Texas Republicans and exposes the absurd lies coming from the left and their media allies. You won't believe the spin they're using to paint this as a crisis. Pags gives you the facts the legacy media refuses to cover. This is the real story behind the redistricting meltdown—don't miss it. Learn more about your ad choices. Visit megaphone.fm/adchoices

Democrats in the Texas legislature are on the run—literally. Pags breaks down why they fled the state to block redistricting and what Governor Greg Abbott is doing about it. Spoiler: He's calling for their arrest. PLUS—Rep. Nancy Mace joins Joe Pags LIVE to make a stunning announcement: she's running for Governor! You'll hear it all straight from her—why now, what she's fighting for, and how she plans to win. Learn more about your ad choices. Visit megaphone.fm/adchoices

Pags breaks down the developing story of an active shooter in NYC - and how CNN is already botching the facts. He also calls out a Florida school board member's cruel social media post celebrating Hulk Hogan's death as “one less MAGA,” pointing out how disturbing it is that someone who would say something so callous is trusted to help guide children. Plus, he shuts down the outrage over Florida's Alligator Alcatraz after a state senator calls it unsafe, reminding listeners that if you don't break the law, you won't end up there. PLUS, Kay Hill joins for Cray News with Kay to talk the new Happy Gilmore movie, entertainment headlines, and more. Learn more about your ad choices. Visit megaphone.fm/adchoices

Joe Pags uncovers a shocking report involving Boston Children's Hospital and raises one major question: why are they getting so much of your tax money? With disturbing allegations and jaw-dropping funding numbers, Pags calls for immediate defunding and explains exactly why this institution should no longer receive federal support. AND – Dr. Scott Jensen joins the show with a bold mission: flip Minnesota red. The former gubernatorial candidate lays into Governor Tim Walz, exposing the failures of current leadership and laying out his plan to restore safety, security, and sanity in the state. Learn more about your ad choices. Visit megaphone.fm/adchoices

July 16, 2025. Week 29. What is a natural history study (NHS)?  And why do we care? We care because we haven't done this before, heal those born with disease. Natural history studies, which examine the progression of a disease over time, can be either retrospective or prospective. Retrospective studies analyze existing data, like medical records, while prospective studies collect new data over time. Both types are valuable for understanding a disease's course and informing research and treatment strategies. ⁠NHS are critical for clinical trial design.  Size and Quality matter.  Validated scales are better than PROs regardless of what the current rhetoric is. What's going on now? USA - https://curesyngap1.org/resources/studies/syngap1-ProMMiS/ - 135+ over three sites, some with FOUR visits, and counting - Adding GCP - Collaborating with world class institutions and excellent clinicians at Stanford, Children's Colorado and, of course, CHOP. USA - https://Citizen.Health/partners/srf has almost 300 patients! Retrospective Health Data. USA - https://rare-x.org/syngap1/ is where we collect PROs. Australia - Dr. Sheffer is running a study, talk to her or Dani. Latin America - SYNGAP1 Argentina with others joining. Europe - https://www.patre.info/syngap1/  Key takeaways for Industry SYNGAP1 is well positioned to work with… Vlasskamp and Wiltrout are published, Citizen Health is growing & ProMMiS is truly exceptional – and growing, and Rare-X is collecting eight key PROs.   Additionally, there are significant international efforts in Australia, Latin America & Europe. Census: https://curesyngap1.org/blog/syngap1-census-2025-update-55-in-q2-2025-total-1636/  If you are in industry and thinking about starting another NHS for your asset, please don't.  Please instead partner with existing PAGs and NHS studies in your key geographies to move faster, have bigger N and not waste precious patients time, we need to accelerate drug development not slow it down by diluting patients and clinicians between too many studies. Baseline papers on SYNGAP1: 1998 - Huganir - SynGAP: a synaptic RasGAP that associates with the PSD-95/SAP90 protein family - https://pubmed.ncbi.nlm.nih.gov/9581761/ 2009 - Michaud - Mutations in SYNGAP1 in autosomal nonsyndromic mental retardation - https://pubmed.ncbi.nlm.nih.gov/19196676/ 2013 - Carvill - Targeted resequencing in epileptic encephalopathies identifies de novo mutations in CHD2 and SYNGAP1 - https://pubmed.ncbi.nlm.nih.gov/23708187/ 2019 - Vlasskamp - SYNGAP1 encephalopathy: A distinctive generalized developmental and epileptic encephalopathy - https://pubmed.ncbi.nlm.nih.gov/30541864/ 2023 - Rong - Adult Phenotype of SYNGAP1-DEE - https://pubmed.ncbi.nlm.nih.gov/38045990/ 2024 - Wiltrout - Comprehensive phenotypes of patients with SYNGAP1-related disorder reveals high rates of epilepsy and autism - https://pubmed.ncbi.nlm.nih.gov/38470175/ Pubmed is at 28 (so less than one a week…) https://pubmed.ncbi.nlm.nih.gov/?term=syngap1&filter=years.2025-2025&timeline=expanded&sort=date&sort_order=asc   CURE SYNGAP1 CONNECT https://curesyngap1.org/curesyngap1connect/   SHARE BLOOD TO THE SRF BIOBANK AT CB! Read here for more information: https://curesyngap1.org/blog/fueling-research-syngap1-combinedbrain-biorepository-roadshow/    VOLUNTEER  Join us: https://curesyngap1.org/volunteer-with-srf/    SOCIAL MATTERS - 4,238 LinkedIn.  https://www.linkedin.com/company/curesyngap1/  - 1,400 followers with 575 Videos on YouTube.  https://www.youtube.com/@CureSYNGAP1    - 11,302 Twitter https://twitter.com/cureSYNGAP1  - 46k Insta https://www.instagram.com/curesyngap1/    NEWLY DIAGNOSED? New families have resources here! https://syngap.fund/Resources      Podcasts, give all of these a five star review! https://cureSYNGAP1.org/SRFApple   https://podcasts.apple.com/us/channel/syngap1-podcasts-by-srf/id6464522917    Episode 175 of #Syngap10  #RareDisease #PatientAdvocacy #SYNGAP1 #SynGAP #ProMMiS