POPULARITY
In the latest episode of Bugs and Drugs, let's dive into the microscopic world of Entamoeba histolytica. What is Entamoeba histolytica you ask? It is a parasitic infection that primarily affects the large intestine but can also travel to other organs like the liver. It can come from contaminated water and/or foods cooked with contaminated water. The signs and symptoms to look for range from mild diarrhea to severe dysentery with abdominal pain and bloody stool. In order to diagnose, you'll have to order a stool microscopy, antigen detection tests and PCR. The best way to treat Amoebiasis will depend on the severity of the infection, including antibiotics and antiparasitic medications. The best way is to prevent the infection in the first place with proper hygiene and safe water consumption. Join Dr. Niket Sonpal as he dives into this common yet complex gut dweller, known as Entamoeba histolytica. February 5, 2024 — Do you work in primary care medicine? Primary Care Medicine Essentials is our brand new program specifically designed for primary care providers to increase their core medical knowledge & improve patient flow optimization. Learn more here: Primary Care Essentials —
I read from entamoeba to enter. The word of the episode is "entelechy". https://en.wiktionary.org/wiki/entelechy https://www.newworldencyclopedia.org/entry/Entelechy Theme music from Jonah Kraut https://jonahkraut.bandcamp.com/ Merchandising! https://www.teepublic.com/user/spejampar "The Dictionary - Letter A" on YouTube "The Dictionary - Letter B" on YouTube "The Dictionary - Letter C" on YouTube "The Dictionary - Letter D" on YouTube "The Dictionary - Letter E" on YouTube Featured in a Top 10 Dictionary Podcasts list! https://blog.feedspot.com/dictionary_podcasts/ Backwards Talking on YouTube: https://www.youtube.com/playlist?list=PLmIujMwEDbgZUexyR90jaTEEVmAYcCzuq https://linktr.ee/spejampar dictionarypod@gmail.com https://www.facebook.com/thedictionarypod/ https://www.threads.net/@dictionarypod https://twitter.com/dictionarypod https://www.instagram.com/dictionarypod/ https://www.patreon.com/spejampar https://www.tiktok.com/@spejampar 917-727-5757
The topic of intestinal parasites and their prevalence is hotly debated in functional medicine. Furthermore, the increasing trend of people performing a ‘parasite cleanse' of the GI tract can be dangerous. Parasites are diagnosed in the stool using microscopy, direct exam, and PCR – but even then, not all parasites should be treated. Some can cause significant illness, yet others are not invasive, self-limiting, and considered nonpathogenic. In today's episode, we give a refresher course on gut parasites, discuss different ways to assess them, and introduce the topic of nonpathogenic parasites that don't need to be treated. Today on The Lab Report: 3:50 Prevalence and transmission of parasites 6:45 What is a parasite? Are there nonpathogenic parasites? 8:10 3 main classes of parasites 10:20 Detecting parasites in the stool 13:10 Nonpathogenic parasites Chilomastix mesnili, Endolimax nana, Entamoeba coli, Entamoeba dispar, Entamoeba hartmanni, Entamoeba polecki, Iodamoeba buetschlii 16:50 Potentially pathogenic parasites 19:25 Question of the Day Why doesn't Genova offer sensitivities for parasites on the GI Effects? Additional Resources: GI Effects Stool Profile Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week's episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don't forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: podcast@gdx.net. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests. See omnystudio.com/listener for privacy information.
TWiV describes how a viral capsid protein activates a bacterial innate immune system that interferes with protein synthesis, and human-associated redondoviruses that infect the commensal protozoan Entamoeba gingivalis. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Jolene Ramsey Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Research assistant position in Rosenfeld Lab CBER/FDA (pdf) Anti-phage defense via capsid detection (Nature) Redondoviruses infect commensal amoebae (Cell Host Micro) A host for redondoviruses (Nat Rev Micro) Letters read on TWiV 1039 Timestamps by Jolene. Thanks! Weekly Picks Dickson – “Cosmic Time Machine” Netflix documentary Kathy – Antarctican accents Rich – Cymothoa exigua, or the tongue-eating louse, Week of wonder: The case for preserving parasites Jolene – Perspective article on best practices for improving graduate admissions Vincent – Why Chandrayaan-3 landed near the moon's south pole — and why everyone else wants to get there too Listener Picks Douglas – On Climate Change and (Active) Climate Management Matt – This Scientist Tracked Bats for Decades and Solved a Mystery About a Deadly Disease Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
The topic of intestinal parasites and their prevalence is hotly debated in functional medicine. Furthermore, the increasing trend of people performing a ‘parasite cleanse' of the GI tract can be dangerous. Parasites are diagnosed in the stool using microscopy, direct exam, and PCR – but even then, not all parasites should be treated. Some can cause significant illness, yet others are not invasive, self-limiting, and considered nonpathogenic. In today's episode, we give a refresher course on gut parasites, discuss different ways to assess them, and introduce the topic of nonpathogenic parasites that don't need to be treated. Today on The Lab Report: 3:50 Prevalence and transmission of parasites 6:45 What is a parasite? Are there nonpathogenic parasites? 8:10 3 main classes of parasites 10:20 Detecting parasites in the stool 13:10 Nonpathogenic parasites Chilomastix mesnili, Endolimax nana, Entamoeba coli, Entamoeba dispar, Entamoeba hartmanni, Entamoeba polecki, Iodamoeba buetschlii 16:50 Potentially pathogenic parasites 19:25 Question of the Day Why doesn't Genova offer sensitivities for parasites on the GI Effects? Additional Resources: GI Effects Stool Profile Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week's episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don't forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: podcast@gdx.net. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests. See omnystudio.com/listener for privacy information.
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.06.29.547007v1?rss=1 Authors: Anders, J., König, C., Lender, C., Hellhund, A., Nehls, S., Shalabi, I., Honecker, B., Lorenzen, S., Meyer, M., Matthiesen, J., Cadar, D., Roeder, T., Metwally, N. G., Lotter, H., Bruchhaus, I. Abstract: Recently, two genes involved in pathogenicity in a mouse model of amoebic liver abscess were identified based on their differential expression between non-pathogenic (A1np) and pathogenic (B2p) clones of the Entamoeba histolytica isolate HM:1-IMSS. While overexpression of a gene encoding the metallopeptidase EhMP8-2 decreases the virulence of the pathogenic clone B2p, overexpression of the gene ehi_127670 (ehhp127), encoding a hypothetical protein, increases the virulence of the non-pathogenic clone A1np, while silencing this gene in B2p decreases virulence. To understand the role of both molecules in determining the pathogenicity of E. histolytica, silencing and overexpression transfectants were characterized in detail. Silencing of ehmp8-2, of the homologous gene ehmp8-1, or of both together in A1np trophozoites significantly altered the transcript levels of 60-350 genes. This strong change in the expression profile caused by the silencing of ehmp8-1 and/or ehmp8-2 implies that these peptidases regulate expression of numerous genes. Consequently, numerous phenotypic characteristics including cytopathic, hemolytic and cysteine peptidase activity were changed in response to their silencing. Silencing of ehhp127 in B2p trophozoites did not affect other genes, whereas overexpression in A1np trophozoites results in an altered expression of approximately 140 genes. EhHP127 appears to be important for trophozoite movement, as silencing negatively affects and overexpression positively affects trophozoite motility. Interestingly, the specific silencing of ehhp127 also impairs cytopathic activity, cysteine peptidase and hemolytic activity. All three molecules of interest, namely EhMP8-1, EhMP8-2, and EhHP127 can be detected in amoeba vesicles. Our results clearly show that the proteins studied here influence the pathogenicity of amoebae in different ways and use entirely different mechanisms to do so. Author summary: The human pathogen Entamoeba histolytica can live asymptomatically in the intestine or become invasive and cause fatal liver abscesses. Approximately 15,000 people die each year as a result of an amoebic infection. Recently, two clones with different pathogenicity (A1np: non-pathogenic; B2p: pathogenic) derived from the E. histolytica isolate HM:1-IMSS were compared at the transcriptome level. Two highly differentially expressed genes (ehhp127 encoding a hypothetical protein and ehmp82 encoding a metallopeptidase) were identified. Analysis of E. histolytica transfectants showed that silencing of ehhp127 and overexpression of ehmp8-2 in B2p trophozoites reduced amoebic liver abscess formation in the mouse model. In this study, we characterized E. histolytica silencing and overexpression transfectants of ehmp8-2, as well as of the homologous gene ehmp8-1 and of ehhp127. It was shown that the altered expression of the metallopeptidase genes has a strong influence on the expression of a large number of genes and that the phenotype is strongly altered as a result. Silencing of ehhp127 does not affect the overall expression profile. However, specific silencing has a negative effect on motility, cysteine peptidase, hemolytic and cytopathic activity. All three molecules were shown to be localized in trophozoite vesicles. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
Today, I am blessed to have here with me Damon Sununtnasuk. He is the founder and CEO of the Sunt Group and Palmara Health which is previously named Nature Cure Labs. He has received numerous awards and recognitions in 2020. These awards include but are not limited to Company of the Year - Health Products & Services, Health & Wellness Nutrition Manufacturer of the Year, 10 Most Influential CEOs in 2022, and many more. Damon is also part of the board of directors of the University of Florida Alumni Association. Damon was born and raised in Florida where he graduated Magna Cum Laude from the University of Florida with the degree of Bachelor of Science in Business Administration. He had an opportunity to live overseas which is why he was able to take his Master of Business Administration at the University of Cambridge. After living overseas, Damon came back to the United States in the year 2015. During this time, he experienced various serendipity. One of them is not having a way of looking after his health. At the time, he was also surrounded by the technological industry, entrepreneurial spirit, and startups. Aside from that, his group of friends was also into MCTs for health purposes which triggered his curiosity. There was even a time when he discovered "oil pulling" which is the process of putting coconut oil in the mouth for 10 minutes before spitting it out to help remove dirt and help maintain the health of your teeth and gums. After these events, he began to research MCTs where he was able to discover the different therapeutic benefits of Medium-Chain Triglycerides. Together with his desire to improve his health and the will to help others, he was able to establish his company in 2015. Currently, they have 3 manufacturing facilities and 35 warehouses in the United States. In this episode, Damon discusses Medium-Chain Triglycerides, specifically Monolaurin, and their role and benefits to the body. He talks about different studies about it and briefly discusses how these supplements are collected and made. He also mentions the Monolaurin product that his company offers. Get your monolaurin supplements with a discount here: Visit https://www.naturalcurelabs.com/products/?ref=KetoKamp Use the coupon code ketokamp for 10% off Take my FREE toxicity quiz to determine your level of toxicity. Visit www.toxicmiami.com for the free quiz. / / E P I S O D E S P ON S O R S Paleo Valley beef sticks, apple cider vinegar complex, organ meat complex & more. Use the coupon code KETOKAMP15 over at https://paleovalley.com/ to receive 15% off your entire order. Upgraded Formulas Upgraded Magnesium & Charge Electrolyte Supplements: http://www.upgradedformulas.com Use KK15 at checkout for 15% off your order. Text me the words "Podcast" +1 (786) 364-5002 to be added to my contacts list. [03:36] Medium Chain Triglycerides and its Benefits in the Body Plant fats contain medium chain triglycerides, coconut oil is a common example. 90% of the fats in coconut oil are saturated fats in which 50% of these saturated fats are MCTs. The health benefits of MCTs have been studied over the years. Some people put it on their coffee, protein shakes, food and etc. When MCTs have been converted in the body, it becomes monolaurin. The three main types of MCTs are Capric, Caprylic, and Lauric Acid. They bring benefits to the body by giving immune support and regulation as well as an aid in ketosis. Damon is focusing on Lauric Acid as based on their research, it helps in immune, digestive, and inflammatory support. [11:33] Everything About Monolaurin: Role and Benefits in the Body Damon read a study about the use of Monolaurin to fight off Giardia Lamblia, one of the most common causes of malnutrition. One of the studies Damon has read used Monolaurin to try cure Giardia Lamblia on animal subjects in which the cure rates reached over 90%. On the other hand, Damon has also read another study wherein Monolaurin was used on the animal subjects first before giving Giardia Lamblia. 60% of the test subjects didn't get sick. Research shows that Monolaurin helps in breaking down the protective envelope of the DNA and RNA viruses. Breast milk contains 6.5% of Monolaurin. Monolaurin can be found on coconut oil and palm oil. However, palm oil can only be harvested on sensitive environments which can affect natural habitats which is why coconut oil is more preferred. [20:21] The Different Ways You Can Take Monolaurin Before taking any supplements, you must contact a health professional in order to determine the right dosage for you to take. Introductory dose - Taking Monolaurin once a day, once every other day, and slowly increasing that up into the therapeutic dosage you're looking to get as an individual. Maintenance - In this way, monolaurin is taken daily to help maintain and regulate the healthy immune response. Some people also take Monolaurin when they feel sick or immunocompromised. [25:30] How Safe is Monolaurin for the Body? Monolaurin, under its chemical name 'Glycerol Monolaurin', is included on the 'Generally Recognized as Safe' list of the FDA. Different studies have not indicated a limit on the use of Monolaurin. Monolaurin impacts gut health. Research suggests that the continuous use of Monolaurin does not creates resistance in the body. [27:38] What Should You Do Before Buying a Product? Check out product testimonials posted on the website or marketplaces. Some product reviews are incentivized and not true so you should try and search about it first. Research through trusted websites like PubMed, familiarized yourself on different products, the science, the background, then the mechanics of it all and sort of trust the science and not necessarily someone's opinion. AND MUCH MORE! Resources from this episode: Website Get your monolaurin supplements with a discount here: Visit https://www.naturalcurelabs.com/products/?ref=KetoKamp Use the coupon code ketokamp for 10% off Check out Nature Cure Labs on social meida Facebook: https://www.facebook.com/NaturalCureLabs Instagram: https://www.instagram.com/naturalcurelabs/ Check out Damon Sununtnasuk LinkedIn: https://www.linkedin.com/in/damonsun/ Academic Resources: PubMed: https://pubmed.ncbi.nlm.nih.gov/ Monolaurin and More: https://www.monolaurinandmore.com/articles/monolaurin-keto-diet Studies referenced: Using monolaurin pre- and post- infection: Fahmy ZH, Aly E, Shalsh I, Mohamed AH. The effect of medium chain saturated fatty acid (monolaurin) on levels of the cytokines on experimental animal in Entamoeba histolytica and Giardia lamblia infection. African Journal of Pharmacy and Pharmacology. January 2014. https://academicjournals.org/journal/AJPP/article-abstract/0C0410F43049 Monolaurin and Ketosis: Avgerinos, Konstantinos I, et al. “Medium Chain Triglycerides induce mild ketosis and may improve cognition in Alzheimer's disease. A systematic review and meta-analysis of human studies.” Ageing Research Reviews, 2020. https://pubmed.ncbi.nlm.nih.gov/31870908/ Customer Reviews: (you can choose to read a couple testimonials in the intro / outro) 600mg Premium Monolaurin: https://www.amazon.com/Natural-Cure-Labs-Premium-Monolaurin/dp/B017RHHEVG?ref_=ast_sto_dp&th=1#customerReviews 800mg Extra Strength: https://www.amazon.com/Natural-Cure-Labs-Strength-Monolaurin/dp/B07GQ1RQHW?ref_=ast_sto_dp&th=1#customerReviews 1:1 L-Lysine + Monolaurin: https://www.amazon.com/Natural-Cure-Labs-L-Lysine-Monolaurin/dp/B07VNV2ZKP?ref_=ast_sto_dp#customerReviews Monolaurin mechanisms in the body: Research on monolaurin's impact on cell mechanisms or organs (ie: liver) is limited, but here is some research. Please don't attribute this to me, as it could be seen as a disease claim. “When monolaurin is consumed, it circulates in the bloodstream & is metabolized in a delayed fashion over 8-12 hours. Monolaurin is not excreted or detoxified out of the body. Instead, it is turned into energy in the form of ketones, [which in turn can] support ketone levels in the body.” - https://dralexrinehart.com/articles/monolaurin-a-secret-coconut-oil-compound-with-powerful-immune-benefits/ “When coconut oil is consumed, the medium-chain triglycerides (MCTs) are broken down into individual medium chain fatty acids and monoglycerides, which can kill or inactivate pathogenic microorganisms inside the body. The antiviral action, attributed to monolaurin (the monoglyceride of lauric acid), is that of solubilizing the lipids and phospholipids in the envelope of the pathogenic organisms causing the disintegration of their outer membrane. There is also evidence that MCFA interfere with the organism's signal transduction and the antimicrobial effect in viruses is due to interference with virus assembly and viral maturation.” - Arora, Rajesh, et al. “Potential of Complementary and Alternative Medicine in Preventive Management of Novel H1N1 Flu (Swine Flu) Pandemic: Thwarting Potential Disasters in the Bud.” Evidence-Based Complementary and Alternative Medicine, 13 Oct. 2010. “[Monolaurin] removes the M protein from the virus envelope resulted in loss of envelope integrity, which is essential for virus infectivity… the loss of envelope integrity results in loss of infectious virus titer” - Hierholzer, John C, and Jon J Kabara. “In Vitro Effects of Monolaurin Compounds on Enveloped DNA and RNA Viruses.” Journal of Food Safety, vol. 4, no. 1, Mar. 1982, pp. 1–12. “Medium-chain saturated and long-chain unsaturated fatty acids, on the other hand, were all highly active against the enveloped viruses... Antiviral fatty acids were found to affect the viral envelope, causing leakage and at higher concentrations, a complete disintegration of the envelope and the viral particles. They also caused disintegration of the plasma membranes of tissue culture cells resulting in cell lysis and death.” - Thormar, H, and et al. “Inactivation of Enveloped Viruses and Killing of Cells by Fatty Acids and Monoglycerides.” Antimicrobial Agents and Chemotherapy, doi:10.1128/AAC.31.1.27. Watch Keto Kamp on YouTube: https://www.youtube.com/channel/UCUh_MOM621MvpW_HLtfkLyQ Take my FREE toxicity quiz to determine your level of toxicity. Visit www.toxicmiami.com for the free quiz. / / E P I S O D E S P ON S O R S Paleo Valley beef sticks, apple cider vinegar complex, organ meat complex & more. Use the coupon code KETOKAMP15 over at https://paleovalley.com/ to receive 15% off your entire order. Upgraded Formulas Upgraded Magnesium & Charge Electrolyte Supplements: http://www.upgradedformulas.com Use KK15 at checkout for 15% off your order. Text me the words "Podcast" +1 (786) 364-5002 to be added to my contacts list. *Some Links Are Affiliates* // F O L L O W ▸ instagram | @thebenazadi | http://bit.ly/2B1NXKW ▸ facebook | /thebenazadi | http://bit.ly/2BVvvW6 ▸ twitter | @thebenazadi http://bit.ly/2USE0so ▸ tiktok | @thebenazadi https://www.tiktok.com/@thebenazadi Disclaimer: This podcast is for information purposes only. Statements and views expressed on this podcast are not medical advice. This podcast including Ben Azadi disclaim responsibility from any possible adverse effects from the use of information contained herein. Opinions of guests are their own, and this podcast does not accept responsibility of statements made by guests. This podcast does not make any representations or warranties about guests qualifications or credibility. Individuals on this podcast may have a direct or non-direct interest in products or services referred to herein. If you think you have a medical problem, consult a licensed physician.
Thank you for joining us for our 2nd Cabral HouseCall of the weekend! I'm looking forward to sharing with you some of our community's questions that have come in over the past few weeks… Anonymous: I wrote in on FB and your support email and was referred to ask here. Can you tell me why the Omega 3 capsules and liquid has different EPA/DHA ratios and the liquid has added DPA. What would be the reason a person would select one option or the other besides not wanting a capsule or liquid? Rani: I have searched the podcast archives and haven't found anything on this topic so I was wondering if you could touch on it. Could you explain the reticuloendothelial system (RES)? Specifically the iron recycling system. I see many practitioners talk about the iron recycling system & how supplementing with iron is unnecessary and possibly dangerous. I would love to get your explanation on this topic. Thank you as I value your knowledge and wisdom. Samantha: Hi Dr. Cabral, Thank you for your time. 10 years ago I had what I thought was painful dermatitis/eczema on my hands, but looks like Chilblains. 2 years ago, my family and I found out we had mold toxicity and are still working through protocol with a functional practitioner (my suspicion is years ago, chilblains was my first symptom from an overactive immune response due to the unknown ongoing mold exposure). Do you have any insight on what root cause(s) is for chilblains and if it's related to histamine and what can be done to heal from the disease, not just manage it. Thank you, Samantha Alicja (Ah-leets-yah): Hi Dr. Cabral, My question today is about protocols and sleep. I started CBO protocol and my sleep got worse. Every day when I took CBO supplements I woke up between 3:00-3:30 am. When I'm up at this time - there is no chance for me to go back to sleep. I took a break from the supplements and my sleep went back to normal. I'm not sure what that means. Meantime I got my stool test results that detected one protozoa (Entamoeba coli) so I decided to do parasite protocol. The same thing happened. I started taking supplements (Para Support) and I started waking up between 3:00-3:30am. What do you think is happening? Any thoughts how to work around that? I need my sleep for proper healing. As always I appreciate your help and thank you greatly! Alicja (Ah-leets-yah):One more question: My test results also showed I have very low levels of pancreatic enzyme: elastase. (It should be more than 200 ug/mL and I only have 28) I take digestive enzymes with every meal. Is there anything else I could do? Do you think HCL would be better for me? Or should I take HCL together with digestive enzymes? Is low elastase reversible or most likely I'm gonna be stuck with low numbers for the rest of my life and rely on digestive enzymes for the rest of my life too? I would love to hear your thoughts. I trust your knowledge very much. Thank you for you your amazing work. Summer: Hi Dr. Cabral! I'd love to hear your thoughts on plant based protein powders. I don't know if I can use actual company names or not, but I've used Genuine Health and Sun Warrior over the last few years and I notice that I CAN tolerated plant based protein in a powder but CANNOT tolerate most plant proteins in whole food form. Looks like both companies are calling their products fermented which also raises a couple of questions. I know you suggest cutting anything fermented if you have gut dysbiosis, but how could any of those ‘good healthy' fermented bacteria survive the processing required to make these powders? So is it necessary to cut these powders with gut dysbiosis? Is the purpose of the fermentation in these cases meant to purely break down the plant into a more digestible form rather than trying to use it to repopulate the gut with good fermented bacteria as you would do with homemade ferments like sauerkraut? I can understand that it might help break down the plant, but I don't see how any good bacteria would ever survive that processing. Thanks so much, and have a great day! Thank you for tuning into this weekend's Cabral HouseCalls and be sure to check back tomorrow for our Mindset & Motivation Monday show to get your week started off right! - - - Show Notes and Resources: StephenCabral.com/2347 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!
While coccidia is the big player in problem protozoa for ruminants, there are a couple other guys I see around that I sometimes care about as well, so Entamoeba and Giardia get a couple minutes of attention in this episode and I also spend some time discussing considerations for treating enteric protozoa in general- why, why, how, and what to consider when you are doing it. Questions, comments, just wanna say hi and send me cute goat pics online? www.goatdoc.com, goatdoccara@gmail.com, Insta: @goat_docSupport this show http://supporter.acast.com/goatdoc. See acast.com/privacy for privacy and opt-out information.
Episode 83: Solitary Rectal Ulcer. Dr Singh explains how we can diagnose and treat solitary rectal ulcer syndrome (SURS) and Brandy gave an introduction regarding Elvis Presley's death. Introduction: Did Elvis Die Pooping?By Brandy Truong, MS4, Ross University School of Medicine. A pop culture trivia fact I always found interesting was that Elvis Presley may have died from trying to have a bowel movement. There are different statements on the cause of death ranging from cardiac arrest, drug overdose, anaphylactic shock, and straining to have a bowel movement. But we're not here to figure out which one is accurate or debate all that. Elvis was found in the bathroom on the floor and many people described it as if he was on the toilet and then fell forward. If he died from pooping, how does that even happen? We're going to explore that a little.When we strain to have a bowel movement, it's called the Valsalva maneuver. This maneuver is divided into 4 stages. Phase 1 is when one first starts straining or bears down. This causes an increase in chest pressure and blood being forced out from the large veins. This is reflected in a rise in blood pressure and a decrease in heart rate. In phase 2, there is reduced venous return to the heart because the blood was forced out of the large veins. Because there is less return to the heart, the heart doesn't pump out as much as it normally would which leads to a fall in blood pressure. The body senses this fall in blood pressure and will compensate by increasing the heart rate significantly. Phase 3 is when one stops bearing down which results in a release of chest pressure. This causes a fall in blood pressure which causes the heart rate to increase as a reflex. In phase 4, the decreased venous return seen in phase 2 is now restored, which causes an increase in blood pressure. The heart rate then decreases as a reflex response. Both blood pressure and heart rate will return to normal. This entire process occurs over a span of a little over 10 seconds.Elvis was known to have a drug addiction and later some doctors found that he had hypertrophic cardiomyopathy which is a condition in which the heart is unable to pump blood well. He abused a variety of pain medications including opioids. Opioids often cause constipation; therefore, if Elvis was constipated and straining, the Valsalva maneuver compounded by heart disease and other unhealthy lifestyles he had would have caused his cardiac arrest. Intense straining during the process of defecation can result in subarachnoid hemorrhage in people with congenital berry aneurysms, for example. If you end up googling to find out how Elvis died, let us know what you think and if you think he died from pooping. This is Rio Bravo qWeek, your weekly dose of knowledge brought to you by the Rio Bravo Family Medicine Residency Program from Bakersfield, California. Our program is affiliated with UCLA, and it's sponsored by Clinica Sierra Vista, Let Us Be Your Healthcare Home. Solitary Rectal Ulcer Syndrome. By Parneeta Singh, MD, Ross University School of Medicine. Discussed with Hector Arreaza, MD.Solitary Rectal Ulcer Syndrome (SRUS) is a benign, rare, underdiagnosed disorder that can mimic and be incorrectly diagnosed as inflammatory bowel disease (IBD) or rectal cancer. The exact prevalence is unknown but in general, it is reported as an annual prevalence of one in 100,000 people. It mostly occurs in the third decade in men and fourth decade in women, with men and women being equally affected. However, cases have been identified in the pediatric and geriatric populations as well. SRUS is a misnomer because although some patients may present with a solitary ulcer, many present with multiple ulcers that may also involve the sigmoid colon. Presentation. Rectal bleeding (with the amount varying from a little fresh blood to severe hemorrhage that may require blood transfusions), mucus discharge, excessive straining, abdominal and perineal pain, constipation, or diarrhea, feeling of incomplete defecation, tenesmus, and rarely rectal prolapse are clinical symptoms associated with SRUS. Presentation may resemble intestinal parasites such as Entamoeba histolytica (amebiasis) and Enterobius vermicularis (pinworm).The underlying etiology is unknown, but a number of mechanisms have been suggested including ischemic injury from the pressure of impacted fecal matter and local trauma due to repetitive self-digitation, although the latter remains unproven. Ulcers usually occur in the mid-rectum which cannot be reached by self-digitation. Additionally, it has been proposed that the perineum's descent along with the abnormal contraction of the puborectalis muscle during defecation results in trauma or a prolapsed rectum with mucosal prolapse being the most common underlying pathogenesis in SRUS. Diagnosis. The diagnosis of SRUS is based on clinical features and proctosigmoidoscopy findings, with histological examination and biopsies being the key to the diagnosis. Imaging studies including defecating proctography, dynamic MRI and anorectal functional studies also aid in the diagnosis with the latter showing that 25% to 82% of SRUS patients have dyssynergia with paradoxical anal contraction. A thorough evaluation is important in ruling out IBD, ischemic colitis, and malignancy.Histology evaluation of biopsy establishes the diagnosis of solitary rectal ulcer syndrome. Findings include fibromuscular obliteration of the lamina propria. This obliteration causes hypertrophy and disorganization of the muscularis mucosa and regenerative changes. There is an abnormal crypt organization. In cases were polypoid lesions are prevalent, the mucosa has a villiform configuration, and in some cases, the glands may be trapped in the submucosa, which is called colitis cystica profunda.Treatments.Various treatment options are available for SRUS with the treatment choice depending on symptom severity and the presence of rectal prolapse. The initial steps, especially in asymptomatic patients, include patient education and behavioral modifications which include a high-fiber diet, straining discontinuation, and a discussion of psychosocial factors. Biofeedback is the next step in those who fail to respond to conservative measures. Biofeedback seems to help by altering efferent autonomic pathways to the gut that reduces straining with defecation by correcting abnormal pelvic-floor behavior. Topical treatments used include corticosteroids, salicylate, sulfasalazine, mesalazine, sucralfate suppositories and topical fibrin sealant. Unfortunately, surgery is necessary in almost one-third of adults with associated rectal prolapse who do not respond to the above treatment options. Surgical treatments include ulcer excision, treatment of internal or overt rectal prolapse, and de-functioning colostomy. Open rectopexy and mucosal resection have shown a success rate of 42% to 100%. In conclusion, SRUS is an uncommon disease that can mimic IBD and rectal cancer. Thus, a thorough and complete patient history and work-up is required to accurately diagnose SRUS, following which patient education, reassurance that the lesion is benign and a conservative, stepwise individualized approach is important in the management of this syndrome.Conclusion: Now we conclude our episode number 83 “Solitary Rectal Ulcer.” Rectal bleeding, constipation, diarrhea, abdominal pain… yes, it sounds like Chron's syndrome, but your list of differentials may be very long. You may want to add to that list Single Rectal Ulcer Syndrome. The treatment goes beyond medications for inflammation and includes pelvic floor training. Even without trying, every night you go to bed being a little wiser.Thanks for listening to Rio Bravo qWeek. If you have any feedback about this podcast, contact us by email RioBravoqWeek@clinicasierravista.org, or visit our website riobravofmrp.org/qweek. This podcast was created for educational purposes only. Visit your primary care physician for additional medical advice. This week we thank Hector Arreaza, Brandy Truong, and Parneeta Singh. Audio edition: Suraj Amrutia. See you next week! _____________________References:“Elvis Presley.” Wikipedia, Wikimedia Foundation, 21 Jan. 2022, https://en.wikipedia.org/wiki/Elvis_Presley#Cause_of_death. Markel, Dr. Howard. “Elvis' Addiction Was The Perfect Prescription for an Early Death.” PBS, Public Broadcasting Service, 16 Aug. 2018, https://www.pbs.org/newshour/health/elvis-addiction-was-the-perfect-prescription-for-an-early-death. Srivastav, Shival. “Valsalva Maneuver.” StatPearls [Internet]., U.S. National Library of Medicine, 28 July 2021, www.ncbi.nlm.nih.gov/books/NBK537248/. Zipes, Douglas. “Valsalva Maneuver.” Valsalva Maneuver - an Overview, ScienceDirect Topics, www.sciencedirect.com/topics/neuroscience/valsalva-maneuver . Qing-Chao Zhu, Rong-Rong Shen, Huan-Long, Yu Wang. Solitary rectal ulcer syndrome: Clinical features, pathophysiology, diagnosis, and treatment strategies. World J Gastroenterology. 2014 Jan 21; 20(3): 738–744. doi: 10.3748/wjg.v20.i3.738. PMID: 24574747; PMCID: PMC3921483. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921483/ Young Min Choi, Hyun Joo Song, Min Jung Kim, Weon Young Chang, Bong Soo Kim, Chang Lim Hyun. Solitary Rectal Ulcer Syndrome Mimicking Rectal Cancer. The Ewha Medical Journal. 2016 Jan 29; 39(1): 28-31. doi: https://doi.org/10.12771/emj.2016.39.1.28. Department of Internal Medicine, Surgery, Radiology and Pathology, Jeju National University School of Medicine, Jeju, Korea. https://synapse.koreamed.org/articles/1058669 Sachin B Ingle, Yogesh G Patle, Hemant G Murdeshwar, Chitra R Hinge Ingle. An unusual case of solitary rectal ulcer syndrome mimicking inflammatory bowel disease and malignancy. Arab J Gastroenterol. 2012 Jun 13(2):102. doi: 10.1016/j.ajg.2012.02.004. Epub 2012 Apr 11. Department of Pathology. PMID: 22980604. https://pubmed.ncbi.nlm.nih.gov/22980604/
In this radiology lecture, we discuss the ultrasound and CT appearance of amebic liver abscess. Key points include: Entamoeba histolytica The post Radiology Case of the Week: Ultrasound & CT of Amebic Liver Abscess appeared first on Radiologist Headquarters.
Chou A, Austin RL. Entamoeba Histolytica. [Updated 2021 Apr 25]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK557718/ --- Send in a voice message: https://anchor.fm/las-poderosas-celulas-nk/message
Es una infección intestinal. Es causada por el parásito microscópico Entamoeba histolytica. En Clínica Abierta, el Dr. Elmo Rodríguez, doctor en medicina, ofrece sabios consejos de salud, así como efectivos remedios basados en la medicina natural. Su co-animadora, Lorraine Vázquez, mantiene el ameno curso del programa con sus interesantes preguntas y comentarios.
This episode covers entamoeba histolytica!
Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin The podcastellani hosts solve the case of the Sailor With Dysentery, and reveal the first virus discovered in Plasmodium species. Subscribe (free): iTunes, Google Podcasts, RSS, email Links for this episode: Matryoshka RNA virus of Plasmodium (bioRxiv) Hero: Rose Gana Fomban Leke Letters read on TWiP 173 Become a patron of TWiP. Case Study for TWiP 173 Successful individual in NY area with 9 months of epigastric pain. Did upper endoscopy, saw in stomach several small mobile white serpiginous moving objects. 2.8 mm. Seem to be trying to burrow into gastric mucosa. One grabbed and sent to lab. History: curious habit of curing his own protein sources. Send your case diagnosis, questions and comments to twip@microbe.tv Music by Ronald Jenkees
The Giardians of the Galaxy solve the case of the Woman With a Colonic Stowaway from Hispaniola, and discuss activation of intestinal tuft cells by Trichinella spiralis. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiP. Links for this episode: T. spiralisand intestinal tuft cells (PNAS) Hero: Carl Theodore Ernst Van Siebold Letters read on TWiP 168 Case Study for TWiP 168 18 month old child, on medical mission for previous year with older sibling and 2 parents. Back in US for 2-3 months, just as leaving remote location were given dose of allbendazole. Call comes to Mom, child is at child care and has passed something. It is serpiginous, 5-6 inches in length, moving a bit. Not flat, but round. Child otherwise fine. Send your case diagnosis, questions and comments to twip@microbe.tv Music by Ronald Jenkees
The TWiPlets solve the case of the Electrician from Tamil Nadu with a Liver Mass, and reveal that dogs and humans share a common Chadian Guinea worm. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiP. Links for this episode: Chadian Guinea worms in humans and dogs (PLoS NTD) Hero: Karl George Friedrich Rudolf Leuckart Image credit Letters read on TWiP 160 Case Study for TWiP 160 Referred to Daniel for consult, 40 yo immigrant from Brazil, a farmer had worked there, family in US. While here 1 y ago sees physician for increased heart rate, arrythmia, premature ventricular contractions, A-fib and flutter, treated by cardiologist then gets implantable defibrillator. Diagnostics: EKG, right bundle branch block; Echo shows heart is dilated with apical aneurysm; thrombosis. Send your case diagnosis, questions and comments to twip@microbe.tv Music by Ronald Jenkees
Vincent and Daniel solve the case of the Panamanian Farmer with Three Weeks of Diarrhea, and discuss how microbes egested during bites of sand flies exacerbate the severity of leishmaniasis. Hosts: Vincent Racanielloand Daniel Griffin Become a patron of TWiP. Links for this episode: Sand fly microbesand leishmaniasis severity (Cell Host Micr) Letters read on TWiP 153 Case Study for TWiP 153 Man in clinic, in city recently, developed rash in groin area, concerned about this. Lives in open relationship with male partner, had sexual encounter with another male. Few weeks. Rash is in the pubic hair, is very itchy. Mostly around umbilicus, can see blue spots in this area. These are skin changes. Buys magnifying glass to look and describes seeing things which we see as well. No notable medical history. Send your case diagnosis, questions and comments to twip@microbe.tv Music by Ronald Jenkees
Montezuma's revenge - Aztec Two Step - whatever nicknames it may be called, if you've experienced it, you know exactly what I'm talking about. Traveler's diarrhea is the most common medical issue that people complain of while traveling in less developed countries. One of parasitic causes of travelers diarrhea is amebiasis, caused by the protozoan parasite, Entamoeba histolytica. According to the Centers for Disease Control and Prevention (CDC), Entamoeba histolytica is well recognized as a pathogenic ameba, associated with intestinal and extraintestinal infections. In this latest installment of the Parasites 101 series on the podcast, Parasitology teacher and author of Parasites: Tales of Humanity's Most Unwelcome Guests, Rosemary Drisdelle joined me to discuss amebiasis.
Vincent, Dickson, and Daniel solve the case about the 33 year old Chinese male with watery diarrhea, and discuss whether arsenic in drinking water might lead to treatment failures for Leishmania infections. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Links for this episode: TWiP 17: Entamoeba histolytica Arsenic exposure and Leishmania treatment outcomes (PLoS NTD) TWiP 14: Leishmania Letters read on TWiP 95 This episode is sponsored by ASMGAP. Case study for TWiP 95 Daniel's patient for this week is a 28 yo single female, returns from beach vacation with new boyfriend. Two weeks in Central America (Belize). Often found secluded beaches. Good health, noticed upon her return had small nodules/papules on front of thighs. Thought were insect bites, became very itchy. Noticed serpiginous red lines forming, radiating out from bumps. Felt things moving in her skin. Benadryl did not help. Daniel say something similar occurs in Lima. Healthy, no allergies, surgeries, no relevant family history, using barrier contraception, sexually active. Only drinks alcohol socially. Boyfriend did not report symptoms. She did lie on sand, used thin fabric. Stayed in hotel. There were wild dogs on beach. During her stay she ate ceviche. No intestinal symptoms. Send your diagnosis to twip@twiv.tv Contact Send your questions and comments (email or mp3 file) to twip@twiv.tv Subscribe Subscribe to TWiP (free) in iTunes, by the RSS feed or by email
Trogocitosis, una nueva manera de “comer”. Investigadores de la Universidad de Virginia han publicado en la revista Nature el hallazgo de una nueva manera por la que algunas células primitivas captan nutrientes. Una ameba, que lleva por nombre Entamoeba histolytica, establece contacto con las células intestinales, pero no las fagocita ni las mata con toxinas, sino que simplemente “mordisquea” la membrana de la célula intestinal y le arrebata pequeños fragmentos que son ingeridos.
Vincent and Dickson discuss how nibbling of human cells by Entamoeba histolytica, a process called amoebic trogocytosis, contributes to cell killing and tissue invasion. Hosts: Vincent Racaniello and Dickson Despommier Links for this episode: Trogocytosis by E. histolytica (Nature) Trogocytosis Entamoeba histolytica (TWiP 17) Entamoeba histolytica life cycle (jpg) Image: E. histolytica nibbling a green cell (credit) Letters read on TWiP 73 Contact Send your questions and comments (email or mp3 file) to twip@twiv.tv Subscribe Subscribe to TWiP (free) in iTunes, by the RSS feed or by email
Vincent and Dickson continue their discussion of protozoan parasites that cause diarrhea with a review of amebic dysentery caused by Entamoeba histolytica. Host links: Vincent Racaniello and Dickson Despommier Links for this episode: Entamoeba histolytica cyst (jpg) Entamoeba histolytica trophozoite (jpg) Entamoeba histolytica life cycle (jpg) Galactose prevents attachment of amoebae to cells (jpg) Entamoeba histolytica life cycle (jpg) Charcot-Leyden crystal (jpg) Letters read on TWiP 17 Contact Send your questions and comments (email or mp3 file) to twip@twiv.tv. Subscribe (free) Click here to receive an email notification when a new episode of TWiP is published.
Discrimination of pathogenic and nonpathogenic Entamoeba histolytica is of great clinical importance. A simple and rapid DNA extraction method that can be used directly with stool specimens was developed without the need for prior cultivation of the parasites. The entire protocol can be performed at room temperature in a 1.5-ml microcentrifuge tube format. There is no DNA precipitation step. The subsequent nested polymerase chain reaction consists of an initial E. histolytica-specific amplification, followed by two separate amplifications using two primer pairs specific for pathogenic and nonpathogenic E. histolytica, respectively. Amplification products can be verified by restriction endonuclease digests. There is no need for hybridizations or the use of radionucleotides. One trophozoite per milligram of stool sample could be detected and differentiated in a 0.1-g specimen.