Podcasts about enteric

The livestock industry has taken a lot of heat in recent years as a major source of greenhouse gas emissions that contributes to climate change.

The livestock industry has taken a lot of heat in recent years as a major source of greenhouse gas emissions that contributes to climate change.

The Missing Piece Everyone Overlooks: Why holistic, functional, and conventional medicine often miss the mark when addressing chronic health issues. Learn about the transformative E.A.S.E. Method, which focuses on balancing the Enteric, Autonomic, Somatic, and Empowered Psychology systems for lifelong health. This in-depth guide explores the limitations of relying solely on testing, supplements, and restrictive diets and emphasizes the critical role of mindset, stress management, nutrition, and movement in achieving sustainable healing. Find practical, actionable steps to reclaim your health and thrive.

Dr. Thomas Kuchenbrod discusses: what is the enteric nervous system & its vital importance to IBD; what are gastrointestinal hormones; and how can we heal the enteric NS? ”You need time, space & energy to heal” ~ Dr. Kuch 

How do low-quality forages affect animal efficiency and enteric methane emissions?  That's the question a student at the University of Guelph has some answers to. Madeline McLennan is studying at the University of Guelph in the Department of Animal Biosciences, focusing on beef nutrition and physiology. Her primary focus right now is on the impact of low-quality forages. For more on this story go to RuralRootsCanada.com

Cows and climate change? You bet! In this Data for Future episode, we explore the role of cow burps in methane emissions and the innovative solutions being developed to tackle this surprisingly significant problem.

In this episode, we explore the critical roles of the enteric nervous system (ENS) and the vagus nerve in digestion and gut motility. We also examine how autonomic nervous system dysfunction can contribute to conditions such as Small Intestinal Bacterial Overgrowth (SIBO). Topics: 1. Introduction to the Nervous System and Its Role in Digestion - Overview of the enteric nervous system (ENS) and vagus nerve - Focus on location, function, and associated dysfunctions 2. Overview of the Enteric Nervous System (ENS) - ENS as one of the three divisions (Sympathetic, Parasympathetic, Enteric) - Location and function overview 3. The Mucosa - Structure and Function of the Mucosa - Epithelium (cells such as enterocytes, goblet cells, enteroendocrine cells) - Lamina propria (loose connective tissue, immune cells) - Smooth muscle layer 4. The Submucosa - Structure and Function of the Submucosa - Thicker connective tissue providing support for blood vessels, lymphatics, and nerves 5. The Submucosal Plexus (Part of the ENS) - Location and Functions of the Submucosal Plexus - Regulation of digestive enzyme secretion, mucin production, and electrolyte balance - Role in creating protective mucus barriers and controlling local blood flow 6. Mucus Secretion and Protection - Role of Goblet Cells - Secretion of mucins and formation of the protective mucus layer 7. Blood Flow Regulation by the Submucosal Plexus - Role in adjusting blood supply during digestion 8. Neuronal Cells of the Submucosal Plexus - Sensory Neurons: Detecting changes in the gut - Interneurons: Processing and integrating sensory input - Secretomotor Neurons 9. Communication Between Neurons and Epithelial Cells - Chemical Signaling and Neurotransmitters - ACh and Vasoactive Intestinal Peptide (VIP) - Serotonin's role in activating sensory neurons and regulating secretion 10. Role of the Vagus Nerve in Digestive Regulation - Vagus Nerve as Part of the ANS - Regulation of digestive secretions, gut motility, and smooth muscle contractions 11. Small Intestinal Bacterial Overgrowth (SIBO) - Connection Between Autonomic Nervous System Dysfunction and SIBO - Reduced motility leading to bacterial overgrowth - Impact on gut environment - Root cause approach Thanks for tuning in! Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Follow Chloe on TikTok @chloe_c_porter Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to purchase products, subscribe to our mailing list, and more! --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support

Rachel Jervis, Foodborne, Enteric, Waterborne, and Wastewater Diseases Program Manager with the Colorado Department of Public Health and Environment, discusses a recent CDC report on foodborne illnesses; Paolo Del Vecchio, Director of SAMHSA's Office of Recovery, outlines the upcoming observances of National Recovery Month; ASTHO welcomes new member Naomi Adeline-Biggs, who was recently appointed as the new Public Health Director for the Oregon Health Authority; and several ASTHO members were quoted in a recent Route Fifty article focused on ASTHO's recent respiratory virus season deskside briefing. CDC Report: Reported Incidence of Infections Caused by Pathogens Transmitted Commonly Through Food SAMHSA Web Page: National Recovery Month 2024 ASTHO Web Page: Naomi Adeline-Biggs Route Fifty News Article: How states can tackle vaccine hesitancy with data  

Our oral board review course includes 100 scenarios that meticulously cover 115 SCORE core topics. Each scenario includes two parts. The first part is a perfectly executed oral board scenario that mimics the real thing. Scenarios are 5 to 7 minutes long and include a variety of tactics and styles. If you are able to achieve this level of performance in your preparation you are sure to pass the oral exam with flying colors. The second part introduces high-yield commentary to each scenario. This commentary includes tips and tricks to help you dominate the most challenging scenarios in addition to practical, easy-to-understand teaching that covers the most confusing topics we face as general surgeons. We are confident you will find this unique, dual format approach a highly effective way to prepare for the test. All of our premium courses are available via our website and apps (iOS and Android).  Users can take notes, pin chapters and download content for offline viewing.   Learn more about the General Surgery Oral Board Review Course at https://app.behindtheknife.org/premium **Institutional Discounts Available - Please email hello@behindtheknife.org to learn more.** Please visit behindtheknife.org to access other high-yield surgical education podcasts, videos and more.  

Along with our regular monthly updates on policy briefs, arable, beef, sheep and milk, In this edition we are also bringing you sector overviews on reducing enteric methane and diversification on a shoestring. We will also be bringing you news on dairy heifers and auction marts. Show Notes 00:45 News in Brief 03:15 Policy Briefs - Crofting Law Consultation, Fly Tipping, red Grouse Licences, Farm Advisory Service Management Grants, Farm Assurance Review 08:01 Arable- Sharp US price falls impact markets, EU and Black Sea harvest progress 12:05 Beef - Finished Price Rebounds in July, BCMS Data, Strong Trade for Stores, MyHerdStats New Feature 15:55 Sheep - Global Meat Outlook, Trade Back In Line 19:56 Sector Focus – Reducing Enteric Methane 25:18 Milk - Production data, prices, 1st cut silage quality, Kingshay annual costings report 30:23 Sector focus – Diversification on a Shoestring 34:30 Inputs – Dairy Heifers 40:35 Management Matters – Marketing Livestock – Auction Marts FAS Resources Agribusiness News August 2024 | Information helping farmers in Scotland | Farm Advisory Service (fas.scot) Other Links: Scottish Government Crofting Law Consultation Wildlife Management & Muirburn (Scotland) Act 2024 Nature Scot website Code of practice for grouse moor management Integrated Land Management Plans (ILMPs) Specialist Advice Farm Assurance Review Survey Kingshay annual costings report The Royal Countryside Fund Royal Countryside Fund 'More than a Mart' report For more information, visit www.FAS.scot Twitter: @FASScot Facebook: @FASScot National Advice Hub Phone: 0300 323 0161 Email: advice@fas.scot

This episode dives into the emerging concept of psychobiotics, exploring how these live (probiotic) microorganisms can positively impact mental health by interacting with the gut-brain axis. We'll provide an in-depth look at the anatomy of the gut lining and the enteric nervous system, explaining how these pathways facilitate communication between the gut and the brain. Additionally, we'll spotlight the psychobiotic Bifidobacterium longum 1714, detailing its mechanisms and benefits for stress and anxiety relief. Topics: 1. General Overview of Psychobiotics - Definition and origin of the term "psychobiotics". - Mental health benefits: alleviating anxiety, depression, enhancing cognitive function, and stress resilience. - Introduction to the gut-brain axis. 2. The Gut-Brain Axis - Detailed explanation of the gut-brain axis. - Overview of the divisions of the nervous system (CNS and PNS). - Further division of the PNS into somatic and autonomic nervous systems. - Division of the autonomic nervous system. - Detailed structure and function of the enteric nervous system (ENS). 3. Gut Lining Anatomy - Layers of the gut lining from the inside out: gut lumen, mucus layers, intestinal epithelium. - Structure and function of the intestinal epithelium and its renewal process. - The role of villi and microvilli in increasing the surface area for nutrient absorption. - Overview of the lamina propria and its immune components. - Overview of the muscularis mucosae 4. Submucosa and Enteric Nervous System (ENS) - Description of the submucosa and its components (blood vessels, lymphatics, nerves). - Detailed structure and function of the submucosal (Meissner's) plexus. - Beyond the submucosa: muscularis externa and the myenteric (Auerbach's) plexus. - Interaction between the ENS and the vagus nerve. 5. Psychobiotics in Action: Bifidobacterium longum 1714 - Introduction to Bifidobacterium longum 1714 and its mental health benefits. - Production of key metabolites (SCFAs, serotonin, GABA) and their roles. - Interaction of metabolites with the ENS and the vagus nerve. - Detailed pathway of signals from the gut to the brain. 6. Other Notable Psychobiotics - Quick overview of other psychobiotics studied for mood regulation: - Lactobacillus rhamnosus GG - Lactobacillus helveticus R0052 - Bifidobacterium breve M-16V - Lactobacillus casei Shirota - Bifidobacterium infantis 35624 - Lactobacillus plantarum PS128 Thank you to our episode sponsor: ⁠⁠Liver Medic⁠⁠⁠ Use code Chloe20 to save 20% on ⁠⁠⁠⁠"Leaky Gut Repair"⁠⁠⁠⁠ ⁠⁠⁠⁠Brendan's YouTube Channel⁠⁠⁠⁠ ⁠⁠⁠⁠https://x.com/livermedic⁠⁠⁠⁠ Thanks for tuning in! Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Follow Chloe on TikTok @chloe_c_porter Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to purchase products, subscribe to our mailing list, and more! --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support

Maik Kindermann, the inventor of the methane inhibitor 3-NOP or  Bovaer®. Earlier this week it was announced that Boaver has been approved for use by the FDA adding the United States to the other 59 countries where its available. Following a directive in 2008 from Feike Sifbesma, the former Chairman and CEO of dsm-firmenich Maik began working on a product to inhibit enteric methane. 16 years later Maik and his team have completed trials 119  and published 80 peer reviewed papers with another 31 in the pipeline. I recently caught up with Maik to hear about his journey developing Boaver and how the conversation on enteric methane has changed over that time. You can listen too our conversation here.

The enteric nervous system describes the nerves of the gastrointestinal tract that autonomously regulate much of its function. Sometimes called the second brain it is a complex network of sensory inputs linked to motor outputs organised into two major plexuses running the entire length of the gut.

In episode 7 we discuss the role of the gut microbiome in weight management, and how weight loss injections like Ozempic and Wegovy are inspired by the body's own hormones. Chris Damman is Clinical Associate Professor and a practising gastroenterologist at the University of Washington in the Department of Medicine/Division of Gastroenterology and editor-in-chief at Gut Bites MD.   He is former Initiative Lead of Gut Health in the Enteric and Diarrheal Diseases team at the Bill & Melinda Gates Foundation.  He holds an M.D. from Columbia University, an M.A. in Molecular Biology & Biochemistry from Wesleyan University, and is board certified in Gastroenterology.  Chris holds research interests focused on food- and microbiome-based therapeutics for metabolic disease. He is a frequent contributor to the press as an expert in gut microbiome. To connect with Chris: www.gutbites.org https://www.linkedin.com/in/chris-damman Studies/ Articles  Discussed: https://theconversation.com/your-body-already-has-a-built-in-weight-loss-system-that-works-like-wegovy-ozempic-and-mounjaro-food-and-your-gut-microbiome-220272 https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)02750-2/fulltext https://www.cell.com/cell/fulltext/S0092-8674(21)00754-6

Capsules for Targeted Therapy: A Game-Changer in Modern Medicine  In this episode we are joined by Vincent Jannin, Lonza's R&D Director, to explore Enprotect, the Award-Nominated Capsule Technology.  Imagine starting your day with a simple capsule that goes beyond simply dissolving in your stomach to reach the place in your body where it is needed most before releasing its medicine. That's just what Lonza's Enprotect enteric capsules do. They are designed to release medication directly into the small intestine, which represents a significant leap in pharmaceutical delivery. They improve patient compliance without increasing production costs and offer targeted delivery for specific therapies such as live biotherapeutic products. This targeted approach is crucial for treatments that require local delivery, for example for Crohn's disease, exocrine pancreatic insufficiency, or Clostridium difficile infection.    In this episode we hear from Vincent Jannin about how advances in polymer science have ushered in this new era of capsules capable of targeted drug delivery. This marvel of modern medicine combines the fields of chemistry, nanoscience, biology, and physics. The creation of a bilayer capsule—comprised of a structural layer for shape and a functional layer for targeted release—both required the development of new technologies and could itself serve as an enabling technology for future therapies.    Vincent Jannin and his team have published several peer-reviewed studies in open access scientific journals, which were mentioned in the podcast:  In Vivo Evaluation of a Gastro-Resistant Enprotect Capsule under Postprandial Conditions (https://www.mdpi.com/1999-4923/15/11/2576)  In Vivo Evaluation of a Gastro-Resistant HPMC-Based “Next Generation Enteric” Capsule (https://www.mdpi.com/1999-4923/14/10/1999)  In vitro evaluation of the gastrointestinal delivery of acid-sensitive pancrelipase in a next generation enteric capsule using an exocrine pancreatic insufficiency disease model (https://www.sciencedirect.com/science/article/pii/S0378517322009966)  Curious to Know More?  Join us this episode as we explore the journey from a simple capsule to a sophisticated drug delivery system and how this advancement reflects a remarkable fusion of science and innovation. Discover how the Enprotect technology not only offers hope for more effective treatments but also exemplifies the relentless pursuit of medical advancement for the benefit of patients everywhere.     KEY TERMS IN CONTEXT:  An enteric capsule is a type of capsule specifically designed to bypass the acidic environment of the stomach and release its contents into the small intestine. The term 'enteric' relates to the small intestine. These capsules are formulated to remain intact in the stomach and dissolve only when they reach the more neutral pH levels of the intestine, ensuring targeted drug delivery.  Enteric polymers are materials used in the construction of enteric capsules. They are chosen for their ability to withstand acidic conditions (like those in the stomach) and dissolve at higher pH levels like those found in the small intestine. HPMC Acetate Succinate is an example of an enteric polymer used for the outer layer of the capsule to ensure the treatment's proper dissolution and release in the intestine.  Live Biotherapeutics (LBPs) refer to live microorganisms used for therapeutic purposes. They are designed to interact with the human microbiome, particularly in the small intestine, and are sensitive to stomach environments. The protection LBPs need before their release in the desired intestinal location is facilitated by specialized capsules.  Fecal Material Transfer refers to a medical treatment involving the transfer of fecal matter from a healthy donor to a patient, often used for conditions like Clostridium difficile infections. The podcast highlighted the potential use of enteric capsules for the delivery of such treatments directly to the small intestine, thereby offering an alternative to more invasive procedures. 

In this episode I talk about the Enteric Brain which is located in your gut. Many of us experience having a gut feeling about things. The enteric brain can help you make decisions and in this episode I tell you how. Making decisions is not always easy and when we make a bad decision it is important not to live in regret about it. See what you can learn from the decisions you make and move forward applying what you've learned. "Truth is Love, Love is Truth" candle is NOW available! Thank you for listening and have a successful week! PLEASE SUBSCRIBE AND SHARE PLEASE FOLLOW THE PODCAST Email: HeartRepairPodcast@gmail.com Follow: @doc_savage_lyfe or @one_yacht_doc

In today's Mind Your Health podcast episode, we explore the intricate workings of the Enteric Nervous System (ENS) and its influence on our health. The journey begins with an in-depth look at the ENS, a complex network of neurons in our gastrointestinal tract that is fundamental in managing the digestive process. We delve into the complex role of the ENS in various stages of digestion, including swallowing, stomach functioning, and bowel movements. The episode also sheds light on the ENS's vital role in regulating the defecation reflex and how it affects our overall digestive health. We get into how the gut's production of serotonin can indirectly influence brain function, affecting our mood and mental health. This leads us to explore the intriguing relationship between gut health and anxiety, revealing how stress and anxiety can alter gut motility and neurotransmitter production. The episode also highlights the importance of the ENS in maintaining a balanced immune response and its overarching effect on the body. Throughout the episode, you will discover:

Lonza Capsules and Health Ingredients is the global leader in the capsule manufacturing market, says Julien Lamps, Associate Director of Global Product Management. Speaking on the PharmaSource podcast, Julien explains how Lonza support the pharmaceutical industry with a range of science-backed capsule innovations. “We are the most well-known in the market for our Capsugel® brand products” says Julien. “Our manufacturing footprint is well established. We have 10 manufacturing sites worldwide, in every region of the world, producing 250 billion capsules a year” This scale means Lonza are able to deliver products worldwide to any pharmaceutical customer regardless of geography or regulatory requirements. “We are really focused on bringing innovations to the market. We helping our customers find new ways of delivering drugs and enabling people and patients to live a better life” Along with pharmaceutical business, Lonza have a large customer-base in the nutrition industry where their capsules are used for vitamins and minerals. Why capsules are the patient-friendly option The common challenges that pharmaceutical manufacturers face is to “improve the bioavailability of drugs” says Julien. “Making sure that they are delivered with the smallest amount within the body, with efficient and consistent delivery” “Capsule are by essence the easiest dosage form. They are very convenient to store, to ship and to get into your body in a simple way.” Julien points out that capsules are a far better patient experience than using syringes and injection, with all the complications this involves for patients and clinics. Enteric-coated capsules The biggest products in the Lonza portfolio are capsules that dissolve in the stomach to deliver their contents in either liquid or solid form. Julien explains that recently they have developed a new range of Capsugel® Enprotect® capsules, which are designed for release in the intestines. “Capsugel® Enprotect® capsules are our latest innovation in the pharmaceutical space. It is a dual-layer capsule that will withstand the acid media of your stomach and will deliver only once it has reached the small intestine.” Enteric properties are built in, the capsule eliminates the need for additional enteric manufacturing steps such as adding solvents. Smart Pills are on the way Julien confirmed that ‘Smart Pills' are a key trend he believes will become a mainstream reality in the next five years, with some projects already in progress. “Smart capsules communicate more information to patients and healthcare professions. They can share information which can help to improve the efficacy of the treatment and ultimately improve patient adherence” he says. Collaboration with customers Collaborating with partners is key for Lonza Capsules and Health Ingredients, Julien says. To help collaborate with customers, Lonza have recently launched the Lonza Capsule Application Lab, a physical facility in France where customers can visit to define their needs, develop projects and launch a proof of concept is done. His advice is to look for parter with a strong regulatory background, who will help you understand what constraints and opportunities you face in the pharmaceutical industry, and who can prove the performance of their products with data. “In capsules there are many players, but customers need to ensure they speak to suppliers who are backed up with scientific research” says Julien. Read more on PharmaSource

Following is a conversation with Dr Indrani Mukhopadhyay, a lecturer at the Institute of Medical Sciences Microbiology and Immunology Group at the University of Aberdeen. Over the last ten years, we've started to understand more and more about why the virome is important in both health and disease. Indrani is an expert in the viral and has been involved in some of the seminal research to characterise profiles and help us understand why the virus is important. So if you're interested in that, this is a great episode for you. We also spoke about probiotics and what a next-generation probiotic might be in terms of its composition, structure and function. We spoke about Indrani's career progression. She's been all over the world involved in exciting research and setting up her new lab recently here in Aberdeen. So we covered a range of topics.  Finally, we spoke about inflammatory bowel disease, how the viral elements of the microbiome might be important and how specific depletions of bacteria might be important too.  As always, I wanted to thank you, the listener, for tuning in and for supporting the podcast. It's fantastic to get the feedback we've been getting about people enjoying it and if you are enjoying it and haven't yet liked and subscribed, please do that. Timestamps: 00:00:00 - Intro 00:01:52 - How did you get into the field of the microbiome? 00:06:32 - Research into developing vaccines 00:12:58 - Effectiveness of vaccines 00:14:24 - Complexity of the rotavirus 00:16:28 - Seasonal flu 00:20:01 - Viruses in our gut 00:24:17 - Viral metagenomics 00:33:06 - Knowledge of viruses greater than of bacteria 00:35:53 - What's the most important part of the microbiome? 00:37:06 - Bacteriophages 00:40:15 - Enteric viruses 00:41:29 - Fungus in the gut 00:42:39 - Viruses keep bacteria in check 00:43:07 - Most exciting development in microbiome research 00:46:10 - Women in science 00:47:00 - Immunomodulator's effects on gut viruses. 00:49:23 - Next-generation probiotics 00:52:20 - Taking probiotic supplements 00:54:28 - Manufacturing bacteria to treat patients 00:55:39 - Benefits of single strain vs consortia 00:56:34 - Universally beneficial probiotic? 01:00:25 - Thanks and conclusion

There are numerous formulations of aspirin available over-the-counter often advertised to decrease gastric issues. Join host, Geoff Wall, as he evaluates a new study to see if enteric aspirin is worth the extra money and effort. The GameChangerBuffered and coated aspirin are purported to cause fewer gastric adverse events. However, no efficacy or safety differences exist in the various formulations of aspirin. HostGeoff Wall, PharmD, BCPS, FCCP, BCGPProfessor of Pharmacy Practice, Drake UniversityInternal Medicine/Critical Care, UnityPoint Health ReferenceSleem A, Effron MB, Stebbins A, et al. Effectiveness and Safety of Enteric-Coated vs Uncoated Aspirin in Patients With Cardiovascular Disease: A Secondary Analysis of the ADAPTABLE Randomized Clinical Trial. JAMA Cardiol. Published online October 04, 2023. doi:10.1001/jamacardio.2023.3364https://jamanetwork.com/journals/jamacardiology/fullarticle/2809795?resultClick=1 Pharmacist Members, REDEEM YOUR CPE HERE! Not a member? Get a Pharmacist Membership & earn CE for GameChangers Podcast episodes! (30 mins/episode)CPE Information Learning ObjectivesUpon successful completion of this knowledge-based activity, participants should be able to:1. Discuss the history of various formulations of aspirin on the US market 2. Discuss the results and limitations of the ADAPTABLE study 0.05 CEU/0.5 HrUAN: 0107-0000-23-331-H01-PInitial release date: 10/30/2023Expiration date: 10/30/2024Additional CPE details can be found here.Follow CEimpact on Social Media:LinkedInInstagramDownload the CEimpact App for Free Continuing Education + so much more!

Wellness + Wisdom Podcast Host and Wellness Force Media CEO, Josh Trent, shares why our gut is the second brain and: In this solocast, you will learn: How making decisions and judgments are related to our nervous system. What the enteric nervous system (ENS) is and why it is our second brain. Brain-gut connection through the vagus nerve. The new studies that are being done on the ENS and microbiome. What the function of neurotransmitters is in the ENS. How fermented foods positively affect our gut and therefore also the ENS, the vagus nerve, and the brain. What our gut feeling truly is and why it gives us false information if we have dysbiosis. How our mental health is involved in the enteric nervous system. The relation between serotonin imbalances and depression. What the consequences of our diet are on our mental health. How Ion Biome supplements support our gut health. Why we should avoid using sunscreen with aluminum. How breathwork stimulates the vagus nerve. Electronic stimulation of the vagus nerve. Why vagus nerve stimulation (VNS) through the ear makes a shift in your nervous system, and why you need to be in communion with your body to see results. Limited Edition: Gold Pumpkin Spice from Organifi Save 20% with code "WELLNESSFORCE" on everyone's favorite Fall treat is here! Pumpkin Spice is more than just a taste phenomenon: it's a portal directly into the nostalgia of fall. With Gold Pumpkin Spice, that taste can also help promote relaxation and restful sleep, nourish the body, and support nightly recovery from a hard day's work.  Click HERE to order your Organifi today including the Green, Red, and traditional Gold! Are You Stressed Out Lately? Take a deep breath with the M21™ wellness guide: a simple yet powerful 21 minute morning system that melts stress and gives you more energy through 6 science-backed practices and breathwork. Click HERE to download for free. Experience Red Light Therapy at HomeSave 10% on your SaunaSpace order with the code "JOSH10" Unlike the traditional methods, near-infrared light works with your body's biology to create radiant heat from the inside out. By using near-infrared's shorter wavelengths in a way that mimics natural sunlight, the light penetrates deeply to raise your core temperature faster. *Review The Wellness + Wisdom Podcast & WIN $150 in wellness prizes! *Join The Facebook Group   BREATHE: Breath & Wellness Program Get 33% off of the BREATHE: Breath & Wellness Program with the code PODCAST33 Boost your immunity and calm your mind with freedom from chronic stress in the modern world. A 21 day guided breath and wellness program using ancient wisdom to boost your immunity, calm your mind, and give you freedom from chronic stress in the modern world. Combining special breathwork infused with safe vape cannabidiol, BREATHE gives you everything you need to let go of old weight, de-stress, and build immunity so you can live your best life. In this special (limited time) offer, you will receive: - Lifetime access to BREATHE - Free upgrades to all future training modules - Free additional training modules - Special VIP coupons for safe vape, essential oils, CBD, nootropics and more - Private WF group access   Josh's Trusted Products | Up To 40% Off Shop All Wellness + Wisdom Approved Products SiPhox - Save 10% with code "JOSH" Holy Hydrogen - Save $100 with code "JOSH" SinuSonic - Use code "JOSH15" for 15% off Tru Kava - Use code "JOSH20" for 20% off MANNA Vitality - 20% off with the code "JOSH20" Mendi.io - 20% off with the code "JOSH20" Adapt Naturals - Save 15% with code "WELLNESSFORCE" BREATHE - 33% off with the code “PODCAST33” MitoZen – 10% off with the code “WELLNESSFORCE” Organifi –20% off with the code ‘WELLNESSFORCE' PLUNGE - $150 off with the code “WELLNESSFORCE" QI-Shield EMF Device- 20% off with the code "JOSH" SEED Synbiotic - 30% off with the code "JOSHTRENT" BON CHARGE - 15% off with the code "JOSH15" SpectraSculpt - 15% off with the code "JOSH15" SaunaSpace - 10% off with the code "JOSH10" Cured Nutrition CBD - 20% off with the code "WELLNESS FORCE" LiftMode - 10% off with the code "JOSH10" Paleovalley – 15% off with the link only NOOTOPIA - 10% off with the code "JOSH10" Activation Products - 20% off with the code “WELLNESSFORCE” SENSATE - $25 off with the code "JOSH25" BiOptimizers - 10% off with the code "JOSH10" ION - 15% off with the code ‘JOSH1KS' Feel Free from Botanic Tonics - $40 off with the code "WELLNESS40" Essential Oil Wizardry - 10% off with the code "WELLNESSFORCE" ALIVE WATERS - 33% off your first order with the code "JOSH33" DRY FARM WINES - Get an extra bottle of Pure Natural Wine with your order for just 1¢ Drink LMNT – Zero Sugar Hydration: Get your free LMNT Sample Pack, with any purchase Earth Runner Shoes - Save 10% with code "JOSH10"  

Dr. Moses Chao is a professor at the New York University School of Medicine. His lab studies how the environment, neuronal activity, inflammation, injury and disease affect the nervous system. They discuss topics related to his new book, "Peripheral: How Your Nervous System Predicts and Protects Against Disease." Topics include: how the peripheral nervous system differs from the central nervous system; the enteric nervous system & gut health; pain sensation; exercise & neuroplasticity; neurodegenerative disease; and more.Support the showSign up for the free weekly Mind & Matter newsletter:[https://mindandmatter.substack.com/?sort=top]Learn how you can further support the podcast: [https://mindandmatter.substack.com/p/how-to-support-mind-and-matter]Become a Premium Subscriber to access full content library, including full premium episodes:[https://mindandmatter.substack.com/subscribe?utm_source=menu&simple=true&next=https%3A%2F%2Fmindandmatter.substack.com%2F]Try the Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for $50 off:[https://www.lumen.me/shop?fid=8731&utm_source=influencer&utm_medium=influencer&discount=MIND]

You may have never thought about the water you flush down your toilet or wash down your shower drain. Turns out, signs of disease can be detected in our wastewater systems from these very sources. Monitoring and analyzing wastewater helps public health experts inform and keep the public healthy. Listen in to learn more about the science of wastewater surveillance.This episode features Jen Hatmaker, an American author, speaker, blogger, and television presenter, in conversation with Supriya Kumar, Program Officer in Global Health at the Bill & Melinda Gates Foundation. Supriya shares how wastewater surveillance can allow countries and communities to understand what pathogens (which cause diseases) are transmitting in the community by analyzing their wastewater (sewage). This provides a more realistic, cost-effective, and equitable picture of where diseases are spreading because it includes information from all populations - including those that don't have access to healthcare. This also allows for countries to take early action to slow the spread of pathogens. In this way, disease surveillance systems will help to prevent the next pandemic by enabling countries to effectively collect, analyze, and share data with their citizens as well as other countries to make informed national and individual health decisions (e.g. staying home, making more tests available, etc).Make Me Care About is produced by Magnificent Noise in partnership with The Bill and Melinda Gates Foundation.To learn more about our show: https://www.gatesfoundation.org/podcast/make-me-care-aboutFor more on The Bill and Melinda Gates Foundation's work: https://www.gatesfoundation.orgTo learn more about wastewater surveillance:Enteric and Diarrheal Diseases Strategy: https://www.gatesfoundation.org/our-work/programs/global-health/enteric-and-diarrheal-diseasesFor more on the work of our guest, Supriya Kumar: https://www.linkedin.com/in/supriyakumar1/Learn more about our host, Jen Hatmaker: https://jenhatmaker.comOur production staff includes Sabrina Farhi, Hiwote Getaneh, Julia Natt, and our sound designer Kristin Mueller. Our Executive Producer is Eric Nuzum and the host is Jen Hatmaker. Hosted on Acast. See acast.com/privacy for more information.

Have you ever thought about why some feelings might be described as gut-wrenching? Or why do the first feelings of love make you feel butterflies in the stomach? It's time to explore how your gut and your brain are connected!Please rate, review, and subscribe and if you have any questions, comments, concerns, queries, or complaints, please email me at neuroscienceamateurhour@gmail.com or DM me at NeuroscienceAmateurHour on Instagram.Also if you have the means/desire to financially support this podcast - please go to https://www.buymeacoffee.com/neuroscienceI really appreciate it!!!Citations and relevant papers are below!Enteric nervous system. qbi.uq.edu.au. Published October 15, 2018. Accessed May 22, 2023. https://qbi.uq.edu.au/brain/brain-anatomy/peripheral-nervous-system/enteric-nervous-system#:~:text=The%20enteric%20nervous%20system%20neuronsCleveland Clinic. Cranial Nerves: Function, Anatomy and Location. Cleveland Clinic. Published October 27, 2021. https://my.clevelandclinic.org/health/body/21998-cranial-nervesMayer EA. Gut feelings: the emerging biology of gut–brain communication. Nature Reviews Neuroscience. 2011;12(8):453-466. doi:https://doi.org/10.1038/nrn3071Carabotti M, Scirocco A, Maselli MA, Severi C. The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems. Annals of gastroenterology. 2015;28(2):203-209.Oligschlaeger Y, Yadati T, Houben T, Condello Oliván CM, Shiri-Sverdlov R. Inflammatory Bowel Disease: A Stressed “Gut/Feeling.” Cells. 2019;8(7):659. doi:https://doi.org/10.3390/cells8070659Vancamelbeke M, Vermeire S. The intestinal barrier: a fundamental role in health and disease. Expert Review of Gastroenterology & Hepatology. 2017;11(9):821-834. doi:https://doi.org/10.1080/17474124.2017.1343143Clapp M, Aurora N, Herrera L, Bhatia M, Wilen E, Wakefield S. Gut microbiota's effect on mental health: the gut-brain axis. Clinics and Practice. 2017;7(4). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641835/‌Zoppi S, Madrigal JLM, Pérez-Nievas BG, et al. Endogenous cannabinoid system regulates intestinal barrier function in vivo through cannabinoid type 1 receptor activation. Am J Physiol Gastr L 2012;302:565.Radjabzadeh D, Bosch JA, Uitterlinden AG, et al. Gut microbiome-wide association study of depressive symptoms. Nature Communications. 2022;13(1):7128. doi:https://doi.org/10.1038/s41467-022-34502-3Wapner J. The link between our food, gut microbiome and depression. Washington Post. https://www.washingtonpost.com/wellness/2023/01/31/gut-microbiome-anxiety-depression/. Published January 31, 2023.Fond G, Loundou A, Hamdani N, et al. Anxiety and depression comorbidities in irritable bowel syndrome (IBS): a systematic review and meta-analysis. European Archives of Psychiatry and Clinical Neuroscience. 2014;264(8):651-660. doi:https://doi.org/10.1007/s00406-014-0502-zWhat's the Difference Between Probiotics and Prebiotics? www.sclhealth.org. https://www.sclhealth.org/blog/2019/07/difference-between-probiotics-and-prebiotics/Liu RT, Walsh RFL, Sheehan AE. Prebiotics and probiotics for depression and anxiety: A systematic review and meta-analysis of controlled clinical trials. Neuroscience & Biobehavioral Reviews. 2019;102:13-23. doi:https://doi.org/10.1016/j.neubiorev.2019.03.023Doll JPK, VázqSupport the show

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.04.19.537136v1?rss=1 Authors: Osorio, N., Martineau, M., Fortea, M., Rouget, C., Penalba, V., Lee, C. J., Boesmans, W., Rolli-Derkinderen, M., Patel, A. V., Mondielli, G., Conrod, S., Labat-Gest, V., Papin, A., Sasabe, J., Sweedler, J. V., Vanden Berghe, P., Delmas, P., MOTHET, J.-P. Abstract: The enteric nervous system (ENS) is a complex network of diverse molecularly defined classes of neurons embedded in the gastrointestinal wall and responsible for controlling the major functions of the gut. As in the central nervous system, the vast array of ENS neurons is interconnected by chemical synapses. Despite several studies reporting the expression of ionotropic glutamate receptors in the ENS, their roles in the gut remain elusive. Here, by using an array of immunohistochemistry, molecular profiling and functional assays, we uncover a new role for D-serine (D-Ser) and non-conventional GluN1-GluN3 N-methyl D-aspartate receptors (NMDARs) in regulating ENS functions. We demonstrate that D-Ser is produced by serine racemase (SR) expressed in enteric neurons. By using both in situ patch clamp recording and calcium imaging, we show that D-Ser alone acts as an excitatory neurotransmitter in the ENS independently of the conventional GluN1-GluN2 NMDARs. Instead, D-Ser directly gates the non-conventional GluN1-GluN3 NMDARs in enteric neurons from both mouse and guinea-pig. Pharmacological inhibition or potentiation of GluN1-GluN3 NMDARs had opposite effects on mouse colonic motor activities, while genetically driven loss of SR impairs gut transit and fluid content of pellet output. Our results demonstrate the existence of native GluN1-GluN3 NMDARs in enteric neurons and open new perspectives on the exploration of excitatory D-Ser receptors in gut function and diseases. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

In this episode, I am joined by Dr. Chris Damman, Chief Medical & Scientific officer at UR Labs, and Marc Washington the Founder & CEO of Supergut. We discuss gut health and why it's essential for overall health. They explain that the gut is not just about digestion but a portal to whole health. They also discuss how what we eat and breathe can affect our gut and body health. The episode highlights the importance of understanding gut health and how healthcare professionals should incorporate this information into patient care.   Show notes:  [00:01:01] Gut health and whole health. [00:04:34] Gut health and total health. [00:07:45] The gut and immune system. [00:12:23] Gut health and nutrition decisions. [00:15:11] Four F's of Longevity. [00:19:03] Probiotics and Gut Health. [00:24:51] Different types of fiber. [00:28:00] Blood sugar spikes and fiber. [00:31:11] Chronic conditions and mind-body connection. [00:36:10] Double burden of disease. [00:40:23] Gut health and interconnectedness. [00:43:46] Following your passions.   More About Dr. Damman: Chris Damman is Chief Medical & Scientific officer at UR Labs.  Prior to joining UR Labs, he was Initiative Lead of Gut Health in the Enteric and Diarrheal Diseases team at the Bill & Melinda Gates Foundation.  He holds an M.D. from Columbia University and an M.A. in Molecular Biology & Biochemistry from Wesleyan University.  He moved west to complete his residency in internal medicine and fellowship in gastroenterology at the University of Washington.  Chris continued on at the University of Washington with a joint appointment in the Division of Gastroenterology and The Fred Hutchinson Cancer Research Center.  He maintains an academic appointment with the University of Washington with research interests focused on investigating the role of diet and microbiome-directed therapies as treatments for inflammatory bowel disease.  Past research activities have included early drug discovery work at Pfizer's Discovery Technology Center in Cambridge, MA and epidemiological surveillance work characterizing Plasmodium drug resistance genes at the Armed Forces Research Institute of Medical Sciences in Bangkok, Thailand. Outside of work, Dr. Damman likes to spend his time running, cooking, eating, and spending time with his wife and three daughters.    More About Marc: Marc Washington is the Founder & CEO of Supergut. His background spans a wide variety of consumer health businesses, including serving as the CEO of Irwin Naturals, a $100M+ supplements company and leading producer of soft-gel herbal formulas sold in over 90,000 retail outlets; President & COO of Beachbody, a $1B+ nutrition and fitness company with products including Shakeology health shakes, P90X, and the Beachbody-on-Demand digital platform; and working 9 years at The Wonderful Co, a $4B agriculture and food & beverage holding company, where he served in a variety of roles including CFO (corporate), EVP Sales (Teleflora), and Direct of Strategy & Operations (FIJI Water). Marc's deep experience in the wellness industry inspired him to found Supergut to help people regain control of their health by harnessing the powerful science of the gut biome. Marc holds an M.B.A. from Harvard Business School and B.S. from Princeton University.  Marc's areas of expertise: Entrepreneurship, Health & Wellness, Gut Health, Metabolic Health, Nutrition, Prebiotic Fiber & Resistant Starch, Food As Medicine, Nutrition & Public Health, Multicultural Health Disparities, Diversity & Inclusion   Resources from this Episode:  Website Our recently peer-reviewed and published clinical study SuperGut on Instagram SuperGut on TikTok SuperGut on Twitter   Follow Dr. Karen Litzy on Social Media: Karen's Twitter Karen's Instagram   Subscribe to Healthy, Wealthy & Smart: YouTube Website Apple Podcast Spotify SoundCloud Stitcher iHeart Radio      

Guests: Dr. Joe McFadden, Cornell University and Dr. Peri Rosenstein, Environmental Defense FundJoining together around the pub to discuss methane emission metrics are experts Dr. Joe McFadden and Dr. Peri Rosenstein. Dr. McFadden, an animal science professor at Cornell University, has focused much of his research and career on studying the interactions between nutrition, environment and animal food production. After discussing mitigating enteric methane emissions during the Real Science Lecture series, more than 600 people listened to the episode. In fact, Dr. McFadden's research in defending the dairy industry has been highlighted in both The Hill and Time magazines. Dr. McFadden began the conversation by mentioning he ultimately believes a percentage of total greenhouse gas emissions is methane. He went on to mention that reducing methane emissions does enhance production, and the industry should be in favor of the shift. 9:04While methane remains a major contributor to agricultural food production, livestock emissions from the glimpse of total greenhouse gas emissions remain relatively low, raising questions on where the focus of enteric methane mitigation should be. Progress is moving the needle from management, genetics, nutrition and enhanced efficiency. Dr. Rosenstein and Dr. McFadden's research focuses on South Asia, specifically India, as there are nearly 75 million small dairy farmers and about 300 million buffalo. Dr. McFadden shared that while the country produces around 20% of total global dairy production, it is also the highest producer of methane. 15:30Cattle are a source of national food security and are a way of life for many people, Dr. Rosenstein added, mentioning the goal is not to pivot completely but instead offer resources to optimize cattle productivity through nutrition, animal health and breeding. 20:22In addition to the Environmental Defense Fund studies in South Asia, Scott Sorrell, podcast host and director of global marketing for Balchem, asked about any other current research taking place. 22:03Just recently, Dr. McFadden said the plans and proposals for the additional construction at the Cornell University research facility were implemented. He added he believes the opportunity to pivot not only allows his team the position to test the next solutions that reduce enteric methane but to continue acquiring various green feeding units. 23:25Dr. McFadden then shifted the conversation to highlight the importance in studying feed duration through green feed study trials. Whether three weeks or three months long, he mentioned they offer a greater understanding when analyzing lactation, supplementation or even replacement strategies. 28:21When discussing strategies for enteric methane mitigation, Dr. Rosenstein mentioned they not only have to have proper feed additives but also be safe for both humans and animals alike. 32:31Wrapping up the conversation, Dr. McFadden summarized the urgency in being transparent on effective additives and encouraged feed manufacturing and feed additive companies to think about markets in new countries as an opportunity to collaborate and expand. 44:10Please subscribe and share with your industry friends to bring more people to join us around the Real Science Exchange virtual pub table.  If you want one of our new Real Science Exchange t-shirts, screenshot your rating, review, or subscription, and email a picture to anh.marketing@balchem.com. Include your size and mailing address, and we'll get a shirt in the mail to you.

Alexia Akbay is the founder & CEO of Symbrosia, a startup producing a seaweed feed supplement for ruminants that can reduce their methane emissions by 90%Ruminent livestock (cows, beef, sheep, goat) are responsible for ~14% of total greenhouse gas emissions (~7Gt of CO2-eq). Enteric fermentation, which is part of the ruminant's digestive process, drives ~40% of these livestock emissions as methane - a highly potent gas with intense short-term warming effectsWith global livestock numbers on the rise in spite of the emergence of meat substitutes and milk alternatives, practical solutions like Symbrosia are needed by food brands and farmers farmers to reduce the climate impact of their activitiesIn this episode, we talk with Alexia about:how her idea started from reading a research paper, evolved into a school project at Yale to become a 20 people strong company operating in Hawaiiwhy is red seaweed so difficult to farm and how is Symbrosia's technology enabling an efficient and consistent seaweed productionhow can this farming model scale up from one the latest facility supplying 1M cows to addressing the 1.5B cows across the globe todayEnjoy the show!To learn more about Symbrosia and livestock farming:Salesforce Ecopreneur show on Symbrosia, including a view of the product & production facilities in Hawaii (video, ~10mn)Concentration and Power in the Food System, by Philip Howard (book, ~200 pages)

S4E11: The Enteric Fight Continues  | Anja Raudabaugh In this episode, Allison Tristao interviews Anja Raudabaugh, CEO of Western United Dairies. They discuss the monumental strides the California dairy industry has made to decrease enteric methane and the challenges that still lie ahead.   For questions about this episode, please contact Anja at anja@wudairies.com or Allison at allison@wudairies.com. To learn more about Western United Dairies, visit wudairies.com. Click Here to become a member!

AABP Executive Director Dr. Fred Gingrich is joined by Dr. Sara Place, an associate professor in Animal Sciences at Colorado State University and affiliated with Ag Next which is focused on sustainable solutions in animal agriculture, to discuss an exciting molecule called 3- nitrooxypropanoal or 3-NOP. Methane is the number one greenhouse gas (GHG) associated with dairy and beef production. The primary source of methanogenesis in beef and dairy cattle is the rumen. If we look at all activities associated with beef production, it is 3.7% of U.S. GHG emissions and about 2% for dairy. This includes enteric methane as well as feed, transportation, manure and other inputs. The primary driver of GHG in the U.S. is burning fossil fuels and release of CO2 into the atmosphere and not animal agriculture, however methane has 28 times the warming potential of CO2, but the half-life is only 10 years, much less than CO2. 3-NOP has a very specific mode of action in the rumen to competitively inhibit the last step of methanogenesis. Research has consistently shown that 3-NOP decreases rumen methanogenesis by 30% in dairy cattle and up to 50% in feedlot cattle. 3-NOP has a different mode of action to ionophores such as monensin. We discuss that 6% of the energy fed to dairy cows and 3.5% of the energy fed to beef cows is lost to methane. Research has not demonstrated an increase in milk production or dry matter intake, but it has had some impact on milk components. We also discuss the practical application of 3-NOP in dairy cows, pastoral beef systems, pre-weaned calves and its impact on future lifetime production of methane, and during the finishing phase of beef production. We also discuss that 3-NOP is a new concept with proven reductions in methane production but there is opportunity for future research to demonstrate potential benefits to producers, animals and consumers as well as the environment. Related publications: Summary of scientific papers from DSM on 3-nitrooxypropanoal DSM sustainability website Use of 3-nitrooxypropanol as feed additive for mitigating enteric methane emissions from ruminants: a meta-analysis The effects of feeding 3-nitrooxypropanol on methane emissions and productivity of Holstein cows in mid lactationA meta-analysis of effects of 3-nitrooxypropanol on methane production, yield, and intensity in dairy cattle Use of 3-nitrooxypropanol in a commercial feedlot to decrease enteric methane emissions from cattle fed a corn-based finishing diet    

You might not know it, but you have a second brain! New gut-brain research shows that neurons in the digestive system communicate directly with those in the brain. In this episode, we do a deep dive into the gut-brain connection and why it matters.Join us for an interview with Fred Travis, PhD, one of our era's leading researchers in the fields of neurophysiology and meditation. In 2015, Dr. Travis co-authored a study on the three Ayurvedic dosha types and how they correspond to three different brain types, which impact everything from a person's gut health and metabolism to their behavioral functioning, and more. You'll learn: All about the gut-brain connectionWhy the enteric nervous system is a second brainWhat Ayurveda has to say about gut healthSigns your gut health is great, vs signs you could use a tune-upWhat your dosha type has to do with your gut health and brain health What foods support brain health and gut healthAnd more!

Wellness + Wisdom Podcast Host and Wellness Force Media CEO, Josh Trent, shares why our gut is the second brain and: In this solocast, you will learn: How making decisions and judgments are related to our nervous system. What the enteric nervous system (ENS) is and why it is our second brain. Brain-gut connection through the vagus nerve. The new studies that are being done on the ENS and microbiome. What the function of neurotransmitters is in the ENS. How fermented foods positively affect our gut and therefore also the ENS, the vagus nerve, and the brain. What our gut feeling truly is and why it gives us false information if we have dysbiosis. How our mental health is involved in the enteric nervous system. The relation between serotonin imbalances and depression. What the consequences of our diet are on our mental health. How Ion Biome supplements support our gut health. Why we should avoid using sunscreen with aluminum. How breathwork stimulates the vagus nerve. Electronic stimulation of the vagus nerve. Why vagus nerve stimulation (VNS) through the ear makes a shift in your nervous system, and why you need to be in communion with your body to see results. Are You Stressed Out Lately? Take a deep breath with the M21™ wellness guide: a simple yet powerful 21 minute morning system that melts stress and gives you more energy through 6 science-backed practices and breathwork. Click HERE to download for free. Is Your Energy Low? Get more superfoods to improve your energy, digestion, gut health plus also reduce inflammation and blood sugar. Click HERE to try Paleovalley's Apple Cider Vinegar Complex + Save 15% with the code 'JOSH' *Review The WF Podcast & WIN $150 in wellness prizes! *Join The Facebook Group BREATHE: Breath & Wellness Program Get 25% off of the BREATHE: Breath & Wellness Program with the code PODCAST25 [spacer height="20px" id="2"] Boost your immunity and calm your mind with freedom from chronic stress in the modern world. A 21 day guided breath and wellness program using ancient wisdom to boost your immunity, calm your mind, and give you freedom from chronic stress in the modern world. Combining special breathwork infused with safe vape cannabidiol, BREATHE gives you everything you need to let go of old weight, de-stress, and build immunity so you can live your best life. In this special (limited time) offer, you will receive: - Lifetime access to BREATHE - Free upgrades to all future training modules - Free additional training modules - Special VIP coupons for safe vape, essential oils, CBD, nootropics and more - Private WF group access   Links From Today's Show  Shop the Wellness Force Store breathwork.io PLUNGE – Save $150 with the code “WELLNESSFORCE" HIGHER DOSE INFRARED MAT - Get 15% off with the code “WELLNESSFORCE15“ Organifi – Special 20% off to our listeners with the code ‘WELLNESSFORCE' MitoZen – Save 10% with the code “WELLNESSFORCE” Paleovalley – Save 15% on your ACV Complex with the code ‘JOSH' NOOTOPIA - Save 10% with the code "JOSH10" Activation Products – Save 20% with the code “WELLNESSFORCE” NEUVANA - Save 15% with the code “WELLNESSFORCE” SENSATE - Save $25 on your order with the code "JOSH25" DRY FARM WINES - Get an extra bottle of Pure Natural Wine with your order for just 1¢ CHILISLEEP - Save 25% on Josh's favorite ChiliSleep products with the code "JOSH" ION - Save 15% off sitewide with the code ‘JOSH1KS' TOUPS - Save 15% with the code "JOSH" Feel Free from Botanic Tonics – Save 40% when you use the code ‘WELLNESS40′ Drink LMNT – Zero Sugar Hydration: Get your free LMNT Sample Pack, with any purchase BREATHE - Save 20% by using the code “PODCAST20” Essential Oil Wizardry: Save 10% with the code ‘WELLNESSFORCE' MY GREEN MATTRESS - Save up to $125 on your order with the code "JOSH" NEUROHACKER - Save 15% with the code "WELLNESSFORCE" ALIVE WATER - Save 33% on your first order with the code "JOSH33" M21 Wellness Guide Wellness Force Community Leave Wellness + Wisdom a review on Apple Podcasts   Shop the BEST Organic Snacks at PaleoValley   Save 15% with the code 'JOSH'   PaleoValley's 100% Grass-Fed Beef Sticks Paleovalley 100% Grass Fed Beef Sticks are the only beef sticks in the USA made from 100% grass fed/grass finished beef and organic spices that are naturally fermented. Their 100% Grass Fed Beef Sticks are unlike anything else on the market. In fact, they were recently voted in Paleo Magazine as one of the top snacks of the year. The reason is that they are committed to making the highest quality, clean products that are free from problematic ingredients. Their beef comes from 100% grass fed cows raised entirely on natural grass pastures by family farmers right here in the USA. As a result they are healthy and happy.   PaleoValley's Pasture-Raised Turkey Sticks Paleovalley Pasture-Raised Turkey Sticks were created to make healthy snacking easier. Their turkey sticks are made from turkeys who are allowed to live as nature intended... on organic grass pastures with plenty of sunshine, fresh air and room to exercise. The result of raising turkeys in such a natural way is a much healthier, clean protein with higher levels of vitamins, minerals, and omega-3s. Unfortunately, virtually all turkey in the USA is conventionally raised with a small portion being "free range" – a virtually meaningless term that simply means the turkeys were allowed access to the outdoors. However, most "free range" turkeys only have access to an outdoor dirt field with no pasture in sight. Their truly pasture-raised turkeys are given full access to outdoor, pesticide-free pasture with plenty of grass and insects for them to nibble on.

Methane is a potent greenhouse gas that traps energy far more efficiently than carbon dioxide. Reduction of methane emissions is thus essential to slowing climate change, and livestock are a major source of these emissions. Dr. Phil Cardoso talks with Dr. Alex Hristov of Penn State University about nutritional strategies for mitigating production of methane by dairy cattle. They discuss the effectiveness of several different feed additives at reducing methane emissions and their effects on DMI and milk production.PaperCast is also available as an audio podcast!Find us on: Apple Podcasts: https://podcasts.apple.com/us/podcast/dairy-focus-papercast/id1530748959Spotify: https://open.spotify.com/show/223Pv4qwRcMFyyy3CXdL3rPodcast Addict: https://podcastaddict.com/podcast/3098543Podchaser: https://www.podchaser.com/podcasts/dairy-focus-papercast-1420022RSS: https://feeds.buzzsprout.com/1327510.rssLinks to papers and other sources mentioned in this video --------------------------------------------------------------- Hristov et al. 2022. Symposium review: Effective nutritional strategies to mitigate enteric methane in dairy cattle.DOI: 10.3168/jds.2021-21398https://www.journalofdairyscience.org/article/S0022-0302(22)00392-7/fulltextInternational Methane Emissions Observatory (IMEO) https://www.unep.org/explore-topics/energy/what-we-do/imeoJoint EU-US Statement on the Global Methane Pledge https://ec.europa.eu/commission/presscorner/detail/en/statement_21_5206Hristov et al. 2015, An inhibitor persistently decreased enteric methane emission from dairy cows with no negative effect on milk production.DOI: 10.1073/pnas.1504124112https://www.pnas.org/doi/10.1073/pnas.150412411273rd Annual Meeting of EAAP. Porto, Portugal, September 5–9 2022.https://eaap2022.org/docs/Final_Programme_EAAP22.pdf#page=53Arndt et al. 2022, Full adoption of the most effective strategies to mitigate methane emissions by ruminants can help meet the 1.5 °C target by 2030 but not 2050.DOI: 10.1073/pnas.2111294119https://www.pnas.org/doi/10.1073/pnas.2111294119Duin et al. 2016, Mode of action uncovered for the specific reduction of methane emissions from ruminants by the small molecule 3-nitrooxypropanol.DOI: 10.1073/pnas.1600298113Pitta et al. 2022, The effect of 3-nitrooxypropanol, a potent methane inhibitor, on ruminal microbial gene expression profiles in dairy cows.DOI: 10.1186/s40168-022-01341-9https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-022-01341-9FAO-IPCC Expert Meeting on Climate Change, Land Use and Food Security. Rome, Italy January 23–25 2017.https://www.fao.org/3/i7068e/i7068e.pdfHristov and Melgar 2020, Short communication: Relationship of dry matter intake with enteric methane emission measured with the GreenFeed system in dairy cows receiving a diet without or with 3-nitrooxypropanol.DOI: 10.1017/S1751731120001731https://www.sciencedirect.com/science/article/pii/S1751731120001731?via%3Dihubhttps://globalresearchalliance.org/research/livestock/networks/feed-nutrition-network/Hammond et al. 2016, Review of current in vivo measurement techniques for quantifying enteric methane emission from ruminants.DOI: 10.1016/j.anifeedsci.2016.05.018https://www.sciencedirect.com/science/article/abs/pii/S0377840116302048Roque et al. 2019, Inclusion of Asparagopsis armata in lactating dairy cows' diet reduces enteric methane emission by over 50 percent.https://www.sciencedirect.com/science/article/abs/pii/S0959652619321559DOI: 10.1016/j.jclepro.2019.06.193Martins et al. 2022, Effects of feeding method and frequency on lactationalperformance and enteric methane emission in dairy cows.https://www.adsa.org/Portals/0/SiteContent/Docs/Meetings/2022ADSA/Abst

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.10.11.511819v1?rss=1 Authors: Kareva, I. Abstract: While the causes of autism spectrum disorder (ASD) remain unclear, some studies have shown that serotonin-mediated effects on enteric nervous system (ENT) correlate with ASD-like behavioral phenotype in mice. Introduced here is a mathematical model of interactions between gut serotonin and its impact on ENT. The model was used to identify three key factors that affect ENT size, namely, serotonin production, its clearance, and its ability to act as a growth factor on ENT. The model was used to reproduce experimentally reported results from a mouse model by Margolis et al. (2016), which connected serotonin-mediated ENT hypoplasia to an ASD phenotype. The proposed mathematical model was used to scale the quantified relationship from mice to humans to show how the combination of these three factors can translate to a quantifiable metric that could potentially be correlated to ASD spectrum. A detailed discussion of how ENT hypoplasia could mechanistically affect CNS activity concludes this paper. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

https://medicienterprises.com/2022/10/01/show-593/

The enteric nervous system is a web-like structure of nerves that can function independent of the sympathetic or parasympathetic nervous systems and is mostly responsible for digestion and its regulation. In this fast-facts episode, Edward reviews the Enteric Nervous System's form and function, as well as the key features that make us who we are.To create this episode, I used information provided by Waxenbaum, Reddy, and Varacallo, 2021 in StatPearls through NCBI Bookshelf, and Mayer, 2011, which can be found here: https://www.ncbi.nlm.nih.gov/books/NBK539845/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3845678/No statement, phrase, or episode of this series—or any episode in this podcast—are intended to treat, diagnose, cure, prevent, or otherwise change your mind or body in any form or manner. This podcast—and this series especially—is meant purely for education purposes for the common person. Please do not rely on any of the information I share in this podcast in any way for your medical or psychological treatment. If you feel that you may have a condition mentioned or not mentioned in this podcast, do not come to me. Instead, immediately go to a trusted psychiatrist, psychologist, therapist, counselor, or other reliable source of information and help for further guidance. Never disregard professional, psychological, or medical advice—nor delay in the seeking of this advice—because of something that you have heard or read from this podcast, this podcast's episode descriptions, this podcast's promotional materials, or any other information explicitly or implicitly generated from this podcast.-----If you love this podcast, show your support by rating, subscribing, and downloading!  The best way to support me is by sharing this podcast with others—the more people can learn, the better we can understand the crazy world we live in :D

00:47 Enteric viruses may spread through salivaEnteric viruses, such as norovirus, cause a significant health burden around the world and are generally considered to only spread via the faecal-oral route. However, new research in mice suggests that saliva may also be a route of transmission for these viruses, which the authors say could have important public health implications.Research Article: Ghosh et al.08:59 Research HighlightsHow devouring space rocks helped Jupiter to get so big, and what analysing teeth has revealed about the diet of the extinct super-sized megalodon shark.Research Highlight: The heavy diet that made Jupiter so bigResearch Highlight: What did megalodon the mega-toothed shark eat? Anything it wanted11:24 Making the tetraneutronFor decades there have been hints of the existence of tetraneutrons, strange systems composed of four neutrons, and now researchers may have created one in the lab. This breakthrough could tell us more about the strong nuclear force that holds matter together.Research article: Duer et al.News and Views: Collisions hint that four neutrons form a transient isolated entity18:46 After Roe v. WadeLast Friday the US supreme court struck down the constitutional right to abortion. In the wake of this ruling, Nature has been turning to research to ask what we can expect in the coming weeks and months.News: After Roe v. Wade: US researchers warn of what's to comeEditorial: The US Supreme Court abortion verdict is a tragedy. This is how research organizations can helpAdditional show linksVideo: The pandemic's unequal tollCollection: The science of inequalitySubscribe to Nature Briefing, an unmissable daily round-up of science news, opinion and analysis free in your inbox every weekday. See acast.com/privacy for privacy and opt-out information.

Dr. Martin answers questions sent in by our listeners. Some of today's topics include: Keto & kidney stones Aloe vera Enteric coated capsules Thinning hair in women Constipation High testosterone in women Polymorphous light eruptions (PMLE) Abdominal cramping Trigger finger  

Dr. Sameer Berry is the Chief Medical Officer of Oshi Health, and he shines a light on the challenges patients face from gastrointestinal conditions and the lack of effective treatments available from doctors for GI-related symptoms. While the reimbursement and payment model discourages a team approach to treating these patients, Oshi Health is taking a multidisciplinary integrated healthcare approach with a focus on the enteric nervous system.  Sameer explains, "Where this comes from is the understanding that anatomically, there's actually an entirely separate nervous system that exists in the GI tract, and it's called the enteric nervous system. So, these are nerve cells, the same types of nerve cells that are in your spinal cord, in your brain, those nerve cells are in your gut. And just like the nerves in your brain respond to environmental stressors that might cause you to feel anxious, depressed, sad, happy, these nerves that are in your gut can respond to environmental stressors. But instead of causing you to feel anxious or depressed, they can cause GI symptoms." "I don't see the use of drugs diminishing. I see us refining the molecular targets for the future of pharmacology and functional GI conditions. Where those drugs target, I think, will start to incorporate our understanding of the enteric nervous system and the interplay of the enteric nervous system with both the parasympathetic and the sympathetic nervous system." @OshiHealth #GITwitter #MedTwitter #GI #IBS #GutHealth #MindGut #EntericNervousSystem OshiHealth.com Download the transcript here

Dr. Sameer Berry is the Chief Medical Officer of Oshi Health, and he shines a light on the challenges patients face from gastrointestinal conditions and the lack of effective treatments available from doctors for GI-related symptoms. While the reimbursement and payment model discourages a team approach to treating these patients, Oshi Health is taking a multidisciplinary integrated healthcare approach with a focus on the enteric nervous system.  Sameer explains, "Where this comes from is the understanding that anatomically, there's actually an entirely separate nervous system that exists in the GI tract, and it's called the enteric nervous system. So, these are nerve cells, the same types of nerve cells that are in your spinal cord, in your brain, those nerve cells are in your gut. And just like the nerves in your brain respond to environmental stressors that might cause you to feel anxious, depressed, sad, happy, these nerves that are in your gut can respond to environmental stressors. But instead of causing you to feel anxious or depressed, they can cause GI symptoms." "I don't see the use of drugs diminishing. I see us refining the molecular targets for the future of pharmacology and functional GI conditions. Where those drugs target, I think, will start to incorporate our understanding of the enteric nervous system and the interplay of the enteric nervous system with both the parasympathetic and the sympathetic nervous system." @OshiHealth #GITwitter #MedTwitter #GI #IBS #GutHealth #MindGut #EntericNervousSystem OshiHealth.com Listen to the podcast here  

While coccidia is the big player in problem protozoa for ruminants, there are a couple other guys I see around that I sometimes care about as well, so Entamoeba and Giardia get a couple minutes of attention in this episode and I also spend some time discussing considerations for treating enteric protozoa in general- why, why, how, and what to consider when you are doing it. Questions, comments, just wanna say hi and send me cute goat pics online? www.goatdoc.com, goatdoccara@gmail.com, Insta: @goat_docSupport this show http://supporter.acast.com/goatdoc. See acast.com/privacy for privacy and opt-out information.

It's been a while, but I'm back for at least a few episodes to talk about enteric protozoans - single celled critters that live in the guts, and may or may not be a problem. First things first- Coccidia. I managed to get a little long winded here talking about these guys and options for treating them when you may have a problem. Questions, comments, just wanna say hi and send me cute goat pics online? www.goatdoc.com, goatdoccara@gmail.com, Insta: @goat_docSupport this show http://supporter.acast.com/goatdoc. See acast.com/privacy for privacy and opt-out information.

In this short episode I summarise a paper entitled "Psychedelics as a novel approach to treating autoimmune conditions". The authors discuss how psychedelics may potentially offer an efficacious strategy for relieving and perhaps even resolving autoimmunity by targeting: - Psychospiritual origins. - Maladaptive chronic stress responses. - Inflammatory pathways. - Immune modulation. - Enteric microbiome populations.

Tim Hand joins Immune to discuss the work from his laboratory showing that environmental enteric dysfunction, a disease caused by chronic malnutrition and infection, and which is associated with reduced growth and oral vaccine failure, is controlled by an increase in intestinal regulatory T cells. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker Guest: Timothy Hand Click arrow to play Download Immune 48 (43 MB .mp3, 71 min) Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Mouse model for EED (Immunity) Time stamps by Jolene. Thanks! Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Today's guest on IBD Heal is Robyn Chuter and our topic for the show is the gut microbiome! Robyn and Shukul are going to do a deep dive into our gut friends and find out what it takes to create a healthy gut flora. We will also cover some of the dos and don'ts of how diet and medication use can affect our Microbiome. Free consultation with High Carb Health: https://www.highcarbhealth.com/healthsurvey/ About Robyn: Robyn Chuter is a university-qualified health practitioner, with a Bachelor of Health Science (and the Dean's Medal for Outstanding Academic Achievement) from the University of New England, a Bachelor of Health Science (Honours) with First Class Honours from Edith Cowan University, and a Diploma of Naturopathy from the Australasian College of Natural Therapies. She is also an Australasian Society of Lifestyle Medicine-Certified Lifestyle Medicine Practitioner, and proud to be a Fellow of the Australasian Society of Lifestyle Medicine. Robyn has an extensive library of articles on her website about the gut microbiome and we highly recommend you take a look: https://empowertotalhealth.com.au/article-library-gut-microbiome/ The gut microbiome has been the hot topic of scientific research in the last few decades. In fact, the field of gut microbiota research has mushroomed so dramatically, that a scientific paper published in 2018 (https://gut.bmj.com/content/67/9/1716) calculated that over four-fifths of the total number of scientific publications focusing on the gut microbiota over the previous 40 years were published in just four years – 2013-2017. And now, so many scientific articles on the topic are published every day that it's impossible to keep up with them all. In just a few decades, researchers have come to understand that the communities of bacteria, archaea, protists, fungi and viruses that live inside our gastrointestinal tract (our gut microbiota), and their collective genetic material (our gut microbiome) are so vital to healthy function that they constitute a distinct organ of the human body. Here are just some of the roles played by the 100 trillion microorganisms that populate our gut: Immune functions: Formation of the gut-associated lymphoid tissue, or GALT (a key component of the immune system in the gut) and ‘training' of our immune cells to distinguish self from non-self, and friend from foe. Gut functions: Maintaining the intestinal barrier (i.e. preventing and repairing leaky gut); digesting complex carbohydrates found in human breast milk and plants; producing short-chain fatty acids which feed the cells that line our colon; keeping disease-causing bacteria, yeasts and fungi at bay; regulating muscle movement in the intestinal tract (motility), and protecting against colon cancer. Metabolic functions: Regulating serum cholesterol, blood glucose levels and appetite. Vitamin production: Producing vitamins B1, B2, B12 and K, along with biotin, folate and alpha-lipoic acid. Central nervous system functions: Stimulating the development of parts of the brain, especially the hippocampus (which plays key roles in motivation, emotion, learning, and memory); and producing chemicals that affect areas of the brain involved in appetite control and food cravings. Enteric nervous system (‘gut brain') functions: Producing neurotransmitters – chemicals that nerve cells use to talk to each other, and to muscles and glands – including GABA, serotonin and dopamine, and influencing the neuroendocrine cells in the gut that also release these neurotransmitters. We hope you enjoy our latest episode, eat plants and lots of them!

Series 2 – Episode 15: BODY AS BRAIN – This week, Julia Seal explores the Mind:Body Connection, what it's all about & what understanding it means for coaching & living into our long lasting Happiness. It's an episode full of surprising delights about our Midlife bodies – from how visualisation can build us muscles even if we're still in lockdown, away from the gym – where does most of our happiness hormone, Serotonin come from (it's not what you think) – do we really have a second brain - how can a physical nerve build our feelings of compassion – who are the 40 trillion organisms free-riding in our gut... Julia shares several ideas on how you can use the power of this Mind:Body puzzle. You can start tapping into the flow between your mind & body – purposefully & intentionally – as part of crafting your Wholebeing Happiness in Midlife. Join Julia here on the podcast to start living into your best life, today. "May you be Happy, May you be Free - there is no better time to coach together!" DON'T MISS an episode. SUBSCRIBE for free & have each one delivered to your device automatically. Subscribe to Julia's Coaching Notes by eMail Subscribe on your favorite podcast player – search for ‘Happiness Matters in Midlife' to finds us Find Everything at: https://happiness-matters.coach/  

In this week's episode, Rachel explains how she begins to work with her clients in her “Restoring Harmony” program. She discusses what it means when she says she is an “Intuitive” and “Holistic” coach.Rachel also explains that she works with her clients through Body, Mind, and Spirit. Through the next few weeks, she will be giving you all a clearer picture of how she weaves these three components into the program and what that looks like for her clients. This week she speaks specifically about the Gut Biome, Microbiome, Gut-Brain. She goes into depth on what this is, how it operates, and how we can best nourish it. Rachel gives some tips and tricks that you can begin doing today to maintain, restore, or replenish health into the gut-brain in order for it to begin working at its optimal capacity.She ends the episode by offering you a challenge of chewing your food slowly, at least 20 times for each bite, gradually working your way up to 40. If you accept this challenge she would love to hear how it went!You can connect with Rachel through the following:IG: @liveyourrawlifeF: Live Your RAW Life (**New Private Facebook Group-Join Today!)E: liveyourrawlife@gmail.comWeb: www.liveyourrawlife.comYour support for the podcast is greatly appreciated:Patreon link:https://www.patreon.com/liveyourrawlifeIf something resonated with you from this week's episode please subscribe to the show and leave a review while you are there. Every time a review or rating is received it opens up the platform that allows the show to reach a wider range of listeners. Your support is greatly appreciated.

This episode covers enteric nerve plexuses!

This episode covers lactose fermenting enteric bacteria!

FDA 连续批准2个治疗胆管癌的靶向药 Lancet 细胞海绵-三叶因子3监测法筛查Barrett食管Nature 胃肠道也有独立的神经系统培米加替尼（Pemigatinib）约20%的肝内胆管癌患者存在成纤维细胞生长因子受体（FGFR）2融合基因突变，培米加替尼（Pemigatinib）是一种选择性FGFR抑制剂。2020年4月，FDA批准培米加替尼治疗复发性的FGFR2基因融合或重排的局部晚期胆管癌。《FIGHT-202研究：培米加替尼治疗晚期胆管癌的临床研究》Lancet Oncology，2020年5月 (1)这个多中心、非盲、单臂、2阶段研究纳入FGFR2融合或重排的晚期胆管癌患者、其他FGF/FGFR基因突变的患者、和没有FGF/FGFR基因突变的患者肱146人。所有入组患者均接受培米加替尼治疗直到疾病进展、不可接受的毒性、撤回同意或医生决定。中位随访17·8个月，FGFR2融合或重排患者中35·5%达到客观缓解（其中3例完全缓解，35人部分缓解）。高磷酸盐血症是最常见的不良事件，49%的患者在研究期间死亡，最常见的原因是疾病进展，与治疗无关。结论：培米加替尼在以前治疗过的发生FGFR2融合或重排的胆管癌患者中均有一定疗效。艾伏尼布（ivosidenib）基因组分析表明，胆管癌中有13%的患者存在IDH1基因突变，艾伏尼布（ivosidenib）是一种新型的小分子靶向异柠檬酸脱氢酶1（IDH1）抑制剂。艾伏尼布2018年被FDA批准用于急性髓细胞性白血病的一线治疗，2020年4月批准用于胆管癌靶向治疗药物。《ClarIDHy研究：针对胆管癌异柠檬酸脱氢酶1（IDH-1）突变的新型靶向疗法的3期临床研究》Lancet Oncology，2020年8月 (2)胆管癌是一种对化疗敏感的癌症。尽管吉西他滨联合顺铂的一线化疗是标准治疗方案，但二线治疗却效果有限。这项国际性、双盲、安慰剂对照的、随机的、3期临床试验中，招募了185例携带IDH-1突变的胆管癌患者，其中大部分患者原发性肝内胆管癌（90%～95%）伴远处转移（92%～93%），随机接受艾伏尼布或安慰剂治疗。中位随访6.9个月时，艾伏尼布组的中位无进展生存期优于安慰剂组（2.7个月 vs 1.4个月，P