Podcasts about ReNu

After Rishi Vamdatt's conversation with Bill and Jackie, his parents Renu and Raag step out from behind the scenes to share how their son became the 16-year-old financial educator behind Easy Peasy Finance. They believe raising a financially savvy kid has less to do with giving money lectures and more to do with letting them swipe the credit card at the grocery store and ask "what happens next"? Their approach was surprisingly simple: money was never taboo, questions were always welcome, and Rishi was allowed to follow his curiosity rather than being scheduled into oblivion. For late-starting parents, the reassuring message here is that you don't need to raise another Rishi. Just talk openly, model your values, and follow the child. This episode covers How Renu and Raag recognized Rishi's unusual interest in money from a very young age Why money, income, mortgages, and family finances were never treated as taboo How everyday activities like grocery shopping became natural financial lessons The family effort behind the early years of Easy Peasy Finance Why Rishi has turned down sponsorships, including significant offers, to protect audience trust How Rishi's parents balance his mathematical approach with the emotional side of money Why letting children lead their interests can be more powerful than filling every hour with activities How Rishi balanced finance with theater, travel, fishing, scuba diving, video games, and being a regular kid What parents can do differently to build financial fluency in the next generation How financial values and openness traveled from grandparents to parents to Rishi   . === SUPPORT  THE  SHOW ===

Posebno pereč problem, ki je posledica suše, so izsušene rečne struge. Tovor, ki se običajno prevaža po rekah, stoji. Nizki vodostaji po Evropi so razkrili marsikaj: stare ladje, v Srbiji denimo nemške bojne ladje iz druge svetovne vojne, v Budimpešti posmrtne ostanke dveh nemških vojakov in mine, tudi v Kölnu so deaktivirali neeksplodirano bombo v Renu. Zlasti zanimivi v Nemčiji pa so kamni, ki pridejo na plan ob nizkih gladinah rek in svarijo pred lakoto.

Two years after researchers identified ReNU syndrome, where are we now?   In 2024, two independent research teams identified the genetic cause of ReNU syndrome, a rare neurodevelopmental condition affecting thousands of people worldwide. The discovery marked the beginning of a new chapter for families searching for answers and opened up exciting new avenues for research.  In this episode, host Sharon Jones revisits the story to explore what has happened since that breakthrough. She is joined by: Professor Nicky Whiffin, Associate Professor and Wellcome Career Development Fellow at Big Data Institute and Centre for Human Genetics, University of Oxford Christina Cox, Co-founder of ReNU Syndrome UK and parent of a child with ReNU syndrome Dr Ana Lisa Tavares, Clinical Lead for Rare Disease at Genomics England Together, they discuss how researchers around the world have built on the original discovery to deepen our understanding of ReNU syndrome, why studying the non-coding regions of our DNA is revealing previously unknown rare conditions, and how collaboration between researchers, clinicians and families is accelerating progress. They also explore how the growing ReNU community is supporting newly diagnosed families and what the future could hold for new treatments.  Links:  Previous episode detailing the discovery of ReNU Syndrome  ReNU Syndrome UK's website  Original research paper from Nicky's team in Oxford  Original research paper from the team based in New York   “It's been only two years since our paper came out about this, and in that time, there are now patient family groups that have been set up all around the world. There is the one in the UK led by Christina and the others. There's the one in the US that's led by a group of four women, and there are ones in France, Spain, like, literally all around the world. And all of these groups are also somewhat coordinated. The leads of these groups meet with each other. They've organised meetups. I've been to ones in the US, the UK, and in France. So the fact that they can mobilise all of that and create such a community so quickly is absolutely incredible.”  You can download the transcript, or read it below. [00:00:00] Sharon: In 2024, two independent research teams identified a genetic cause of a rare neurodevelopmental condition affecting thousands of people around the world. Since then, that initial groundbreaking discovery has grown into something much bigger, bringing together families, researchers, and clinicians, and building a clearer picture of what we now know as ReNU syndrome.  [00:00:26] Sharon: Welcome to Behind the Genes, the podcast that covers everything from cutting-edge research to real-life stories in genomic healthcare. I'm Sharon Jones, and in today's episode, we're looking at what's happened since that discovery, what researchers are continuing to learn, and what the future could hold for people living with  ReNU Syndrome and their families.  [00:00:46] Sharon: To help us understand more, I'm joined by Professor Nicky Whiffin, Christina Cox, and Dr. Ana Lisa Tavares. So, two papers were published around the same time for this condition. To start us off, Nicky, you worked on one of these papers. Could you explain how this journey first began?   [00:01:05] Nicky: Yeah, so this was two years ago now, back in early 2024, where two research teams, so us based in Oxford and a, a group based in New York, were both looking at the data within the National Genomics Research Library, and we both kind of somewhat simultaneously found that there was variance in this very, very small gene, it's called RNU4-2, were found in individuals with previously undiagnosed neurodevelopmental disorders.  [00:01:39] Nicky: And this was very, very striking because we initially actually identified the same single DNA change or mutation in 40 or so different individuals within the National Genomics Research Library, and we normally expect to see a whole host of different variants. We don't expect to see the same one.  [00:01:59] Nicky: So this was a really, really surprising finding. And it was through a collaboration, large scale collaboration across the world where we started contacting our other collaborators who have similar collections of patients who have been genome sequenced to ask if they had any individuals with DNA changes in this gene.  [00:02:17] Nicky: And we found some in the US, some in, in Australia, some in France and Germany. So very, very quickly built up this, this complete picture of variants in this gene, causing this rare neurodevelopmental disorder   [00:02:35] Sharon: of people finding it at the same time, what, what did that feel like?  [00:02:39] Sharon: Like, give us a ense of, like, that compelling, "We think we found something." What was that like?   [00:02:46] Nicky: I didn't believe it initially. You're always told when you're a scientist that if it looks too good to be true, it's, it's not true, and this basically lit up like a beacon. There's this particularly one DNA change that we found in, um, I think it was about 40 different individuals, and we don't really expect that to be the case.  [00:03:04] Nicky: We normally expect these genetic variants to be somewhat randomly distributed across the genome. So to find 40 individuals with exactly the same DNA change was very, very surprising. So initially, I didn't believe it. The whole team, including folks at Genomics England, spent a lot of time trying to check that these variants were real and tried to disprove the result, tried to find any other way in which any other reason why we would be seeing this.  [00:03:31] Nicky: And after a little while, we had to concede that we couldn't disprove it, so it must be true, and that, that was a very exciting moment.   [00:03:38] Sharon Jones: Was it the case that over in the States, the exact same thing was happening?   [00:03:42] Nicky: I think we found out when we were both speaking at the same conference, actually. So we didn't actually know that we, that we'd both come across the same result.  [00:03:49] Sharon: If you want to check out our previous episode on this initial discovery, you'll find a link to it in the episode description.  [00:04:00] Sharon: So Christina, tell us a bit about your situation, your family situation, and for our listeners, what ReNU is.   [00:04:05] Christina: So ReNU is, to us, is a family. We got a family when we got diagnosed with  ReNU. Beau - Arabella - already had other diagnosises, but people had always said to us, "Oh, there's something else. There's something else.  [00:04:20] Christina: We're not sure what it is, but there will be something." And then when we got  ReNU, it was like, "Oh, okay, amazing. What do we do? What is it?" Because there was only four lines on Wikipedia when we first got told about it, and there wasn't anything that, ourselves could find. So we kind of went onto Facebook and looked for groups and different people, and there wasn't really anything except for Jess in America.  [00:04:46] Christina: And then it grew, and then it kind of, we ended up finding more people in the UK and, like, all over. But for us, it didn't really change how we perceived Beau. It just made life easier. Like, knowing there was other families out there that we could find advice from and support from, and that we kind of knew what we had and going forward then, like, finding researchers and connecting with everybody.  [00:05:15] Sharon: Yeah. And for those who don't know, can you talk about what  ReNU is? Like, how does it affect Beau?   [00:05:20] Christina: So with Beau and  ReNU , it affects her with developmental delay. She's non-verbal. She's incontinent. She suffers for walking, so she can do a little bit of walking, but she needs a wheelchair It affects her mood swings.  [00:05:38] Christina: It just affects everything. Although she has it, she's still a happy, outgoing, very stubborn, just kind of "keep-going" child. But it affects her in everything, like eating, sleeping.   [00:05:51] Sharon: It sounds like life is, you know, very challenging on a day-to-day basis, lots of considerations. How did you feel when you finally got this diagnosis after years of wondering and waiting, not knowing?  [00:06:02] Christina: Finding out was, like, really emotional because it was like, "Oh, wow, so we have this diagnosis. Now what? What are we looking for? What's going to happen?" And then we were kind of like, "Oh, but there's not many people that had it." Because we found out in the August, so then it was trying to find people. But it has been life-changing to know that we're not on our own and that there is other people around.  [00:06:28] Sharon: Yeah, tell us a bit more about that. How did it feel to get that diagnosis?   [00:06:32] Christina: It was quite strange because our pediatrician rang us and said, "Oh, we've got a diagnosis. She's got RNU4-2." And we were like, "Okay, so what's that?" And she's like, "I don't really know. There's four lines on Wikipedia at the moment."  [00:06:46] Christina: She goes, "I don't like Wikipedia," but we still kind of... That was it. So then we went on a mission to find and look for where we could find support and find other families.   [00:06:58] Christina: At that point, I didn't know of anybody in the UK, and my husband found Jessica in America. What then, kind of, we had somebody to talk to, and then families in the UK kind of started appearing.  [00:07:09] Christina: So we ended up getting a whole network of people to bounce ideas off and talk about how it affects their children and what's for the future and things like that. It was really nice.   [00:07:22] Sharon: Yeah, yeah, I can imagine. So Ana Lisa, how do these findings contribute to a growing understanding of the condition?  [00:07:29] Ana Lisa: So this was an amazing discovery. Although we're finding new rare conditions quite often, not on this sort of scale. It was also an amazing finding because a lot of the genes that we know are associated with rare conditions are genes that encode proteins, and in the 100,000 Genomes Project, we were doing whole genome sequencing, and Nicky and her team were looking in the parts of the genome that don't encode for proteins.  [00:08:03] Ana Lisa: And so this was, uh, exciting from that point of view as well. So the vast majority of our genome, more than 98%, does not encode for proteins, but it's relatively unexplored. And if we think about our genome and the letter code that makes it up, which is the manual for how our bodies are built, and grow and function day-to-day.  [00:08:30] Ana Lisa: Those 3 billion letters, if you, if you printed them out in a 12 font regular print, it would stretch so far you could fly, I think, from London to Paris several times, maybe three times or something. And so, this actual gene is a very, very small gene, less than 150 of those letters. So again, it was incredible to find that by comparing across many, many different genomes in the National Genomic Research Library.  [00:09:00] Ana Lisa: Going back to your question about a growing understanding of a condition, it was a completely new condition, but it also opened up looking at other related genes and actually now more disorders that are being found, like RNU2-2 by colleagues in the US, and that might be one of the most common recessive genetic neurodevelopmental disorders.  [00:09:27] Ana Lisa: So it's really, really opened up this understanding about these types of disorders and also those non-coding parts of our genome and the power of collaboration and being able to look across many different whole genomes at the same time.   [00:09:44] Sharon: Yeah. And Nicky, you've been involved in much of this research journey.  [00:09:50] Sharon: What have been some of the biggest advances or learnings for you so far?   [00:09:55] Nicky: I think the biggest one is just how common, or how frequent, these disorders are. So what we discovered recently in terms of new genetic disorders were rarer and rarer conditions, and that's why we hadn't seen them before. But from going from looking at the protein coding genes to looking at these non-coding genes, we found something that was as frequent as disorders that were found in the early 2010s when we first had large-scale sequencing projects that looked at the protein coding genes.  [00:10:26] Nicky: So that was really, really surprising. And we now know there's this whole class of disorders. So RN4-2, this gene encodes this -- Well, it produces this small RNA that works in this huge molecular machine that is called the Splicer Zone, that mediates the processing of most of the other genes across the genome.  [00:10:50] Nicky: And there are lots of these little RNAs that work in this molecular machine that are called the small nuclear RNAs or the snRNAs And we now know that there are a whole multitude of different disorders associated with different ones of these spliceosomal small nuclear RNAs, and that's really incredible.  [00:11:09] Nicky: And for RNU4-2 itself, we also now know that there are, there's not just RENE syndrome, uh, which is a dominant disorder caused by chance de novo variants that are newly arisen in a child, but also a recessive disorder where a child inherits one, uh, gene mutation from each parent. And also another finding that there is a region of the gene where we find DNA changes that cause retinitis pigmentosa, so a retinal phenotype. So we now know a huge amount more about this single gene, but also all of this different class of genes or RNAs that work in the same molecular machine, uh, which is, is really fascinating biologically   [00:11:52] Ana Lisa: Vicky, while you were talking, I was thinking about the splicing and how a bit like this podcast recording, you're going to splice out the kind of extreme, the noise that wasn't supposed to be there.  [00:12:03] Ana Lisa: And actually, you could make slightly different versions of this podcast, couldn't you? And that's, that's what, what's happening in our bodies for a lot of our genes that, that the kind of output can be varied slightly.   [00:12:15] Sharon: So Christina, how has collaboration been involved across the community and with researchers?  [00:12:21] Sharon: You know, what sort of things have you been doing?   [00:12:23] Christina Cox: So it's amazing to have researchers that are so open and amazing to work with the families. So at the moment, we are just putting together like a panel to discuss questions from families, to then be able to answer families, to work very closely with the researchers for what things are happening and the progress within.  [00:12:47] Christina: It's just amazing to be able to work with researchers. They're just fantastic.   [00:12:52] Sharon: And from what I understand, like, you, you have a charity, don't you? Can you tell us a bit more about that and how that came about?   [00:12:58] Christina: So we have ReNU Syndrome UK, and it came about as there was a group of us parents that were like, we wanted to be able to support other families, knowing what it was like for us when we first started.  [00:13:12] Christina: It was very difficult. So we wanted to start a charity that can support families and signpost them, give them the opportunity to have family meetups once or twice a year, so we can work with scientists and specialists to keep everybody in the community, like the ReNU family, up to date. But being able to connect with so many families, because a lot of the doctors don't really know of ReNU Syndrome yet.  [00:13:46] Christina: So if we have a problem or a question, we put it in the WhatsApp group, and then somebody can answer it because they've been through it, or they, they've just asked the question. So it's just an amazing resource for everybody   [00:14:02] Sharon Jones: That sounds amazing, and it sounds like you've all obviously become experts by experience.  [00:14:04] Sharon: So, like you say, you kind of know more, you know, as the science develops, but you're living it every single day   [00:14:10] Christina: It's kind of, you go into the hospital and they're like, "Oh, what's ReNU Syndrome?" And then you're like, "Ugh." So, then you just have to say it all. But, and then it's kind of them bringing, teaching new people who don't know about it in the medical professional.  [00:14:26] Christina: We always give them the website so that they can go and then find, but being able to put more medical stuff on the website, it just helps everybody, and it's just broadening it out to as many people as possible. Because there's still a lot of people undiagnosed with RNU syndrome. It's, now it's easier to be signposted, but it's just keeping that connection.  [00:14:49] Sharon: Yeah. And, and from what I understand, it's got quite an interesting sort of origin of a name, RNU. Where did that... Do you know much more about where that came from?   [00:14:57] Christina: So, Nicky is the amazing person who, um, sorted the name and um, the origin. So, I'll pass that over to Nicky to answer that question because she's just amazing   [00:15:11] Nicky: Uh, so the name ReNU syndrome is an interesting story.  [00:15:13] Nicky: So, a lot of disorders or diseases are named after people. So, we all know Alzheimer's, Parkinson's, etc. And they're often scientists or clinicians that have spent a lot of time working on them. I think that's a little bit odd. I don't think it's the first thing that somebody should know about a disorder, is the name of somebody who's, who's worked on it or studied it.  [00:15:36] Nicky: But they're a very, it's very hard to find an alternative. When we were initially doing the press release around our paper, we had a quote from one of the mothers, Nicole Cedar, who has a, a wonderful daughter called Mia Joy, and she said that within their family, they like to refer to RNU, to RNU4-2 as ReNU, which is a really nice play on the RNU in the gene name.  [00:16:00] Nicky: So then I had an idea, okay, let's just change the spelling to make the, the kind of big R, little E, large N-U, then it would link to the gene name, but also would be a name that speaks to hope and the renewed hope of being given a diagnosis.   [00:16:13] Sharon: Yeah, absolutely, and that's a great, a great story and a great way of kind of making it feel like there is, there is always hope.  [00:16:20] Sharon: So, you know, Nicky, you're now part of the patient community. In a way. You know, so how does it feel to be on that other side of it from that sort of research perspective and now kind of, you know, in that, in that community?   [00:16:34] Nicky: It's amazing. I've got a new family as well. It's not, not just Christina and everybody.  [00:16:39] Nicky: I kind of, I'm a, a basic scientist. I'm not a clinician. Up until this point, we've always been one or two steps removed from actually interacting with the families themselves. Um, so my life has changed an awful lot over the last couple of years, uh, where now, um, I kind of talk to Christina or the folks in the US, really regularly, kind of on a weekly basis.  [00:17:02] Nicky: Um, so that's really different. And I just kind of want to highlight just what these families have achieved. So it's been only two years since our paper came out about this, and in that time, there are now patient family groups that have been set up all around the world. There is the one in the UK led by Christina and and the others.  [00:17:26] Nicky: Um, there's the one in the US that's led by a group of four women, and there are ones in France, Spain, like, literally all around the world. And all of these groups are also somewhat coordinated. The leads of these groups meet with each other. They've organised meetups. I've been to ones in the US, the UK, and in France.  [00:17:46] Nicky: So the fact that they can mobilise all of that and create such a community so quickly is absolutely incredible. And they've got families, they've got so many researchers that are interested in the cause. They're interacting with the pharma companies. They've upskilled themselves to learn so much about genetics.  [00:18:04] Nicky: And it's just an absolutely incredible thing to watch. They're so, so inspiring.   [00:18:09] Sharon: And from what I understand, Christina, you feel, you know, very passionate about Nicky in the same way, about your paths crossing in this way.   [00:18:16] Christina: Oh, my, yes. Every time I see Nicky, I've met her a couple of times, like, in person now, I just cry.  [00:18:22] Christina: I literally, we saw her at the UK meetup, and she walked in the door, and that was it. I was done. I was like, it's just meeting somebody who has changed so many lives and brought a community to other families. It's just amazing. And the support that Nicky's giving us weekly, daily, is just amazing. It is just life-changing for all of us.  [00:18:49] Sharon Jones: It's such a powerful connection. So Ana Lisa, why is collaboration between researchers, clinicians, and families so valuable in the rare disease research space? You know, and what role do large scale research projects and data sharing play in discoveries like this?   [00:19:06] Ana Lisa: Collaboration is completely incredibly valuable and for progress in the rare disease space where there's just so much still to learn.  [00:19:16] Ana Lisa: So more than half of patients and families where, uh, they're seeking a potential diagnosis, we're not yet able to, to find one, and there's so much yet that we still need to learn, and collaboration in so many different spaces and directions and across different spheres enables this progress. So for example, the fact that we have a really connected, uh, National Health Service and really close working between the NHS and Genomics England so that we can, for those patients and families that, that consent to their de-identified data being shared in the National Genomic Research Library, be able to work with many, many different researchers, uh, whether they're academic, institutions, industry, and try and find all the patients that could benefit from a new diagnosis and, uh, potentially new therapies in future clinical trials.  [00:20:21] Ana Lisa: And without that collaboration, it would be really, really hard to find all those people So because we sort of have a clinical research interface where we can go back to clinical teams and therefore to patients and families, even if there's a really, really ultra-rare condition with very few people known to have it that could be under different specialties in different regions, we would be able to contact their clinical team.  [00:20:51] Ana Lisa: So I think that, that collaborative working with the NHS is really powerful across researchers worldwide. Like in this example where a group in Oxford and a group in US were able to make this finding and then all the other findings that are coming from it. And really, without being able to compare across thousands of genomes, one wouldn't have been able to see this, this particular signal and see that there were more than 100 patients, and that was really powerful.  [00:21:20] Ana Lisa: If you just had one genome, you could never have made this novel discovery. I think the other thing is that, and Nicky will say that, you know, she, she then contacted her collaborators who also had access to, to, to data that had been shared by other families and could compare. And again, it's a whole sort of network across the globe.  [00:21:41] Ana Lisa: And we know that there are going to be many more diagnoses to be found. But also, um, I think collaboration will allow us to find new, new treatments. So if we can start to design treatments that target the DNA and RNA at, at source, then actually you could collaborate and say, "Well, this type of genetic mechanism could be targeted in the same way, potentially across even more than one rare condition and reach even more patients."  [00:22:13] Ana Lisa: And actually the power of collaboration across the ecosystem is that hopefully we'll end up with a pathway that can actually go from finding a new genetic finding, like Nicky and her team made, to helping all the people who could benefit from a diagnosis, having one, and then can one develop a treatment and get it to as many patients?  [00:22:42] Ana Lisa: And, and I think that will really demonstrate the power of collaboration.   [00:22:47] Sharon: Yeah. Absolutely, and it can only, you know, benefit those families who have to wait such a incredible amount of time.   [00:22:55] Ana Lisa: There's been such a diagnostic odyssey, and as more diagnoses are made, it becomes obvious that there's, uh...  [00:23:03] Ana Lisa: and it was, it's already well-described, the therapeutic odyssey. Um, but hopefully these sort of novel understanding of our genome and opening up new biological avenues to treat, um, hopefully will also enable many more new treatments to be developed.   [00:23:21] Sharon: Absolutely, and that is the key word there is, is that hope.  [00:23:24] Sharon: So, so looking ahead, Nicky, what developments are you most hopeful about over the next few years?   [00:23:31] Nicky: That's a difficult question. There's so much, so much happening. One thing is that we are gearing up to do large scale studies across the world to understand more about the progression of ReNU. So you might call them large scale natural history studies or just large scale profiling studies where we can do a range of different tests on ReNU patients and, and monitor them over time.  [00:24:02] Nicky: So do those at regular, regular intervals over time so we can see what the progression looks like. And that's really important for trying to think about whether we can treat RNeU syndrome. And on that note, I'm very also excited about the potential for therapeutics. There's lots of people all around the world, both, uh, in academic settings, but also in pharma companies trying to work out whether this is something that we can treat.  [00:24:30] Nicky: There's some very promising early data to show that we can selectively remove the RNA containing the mutation from cells, uh, leaving the copy of the RNA that doesn't contain the mutation intact so that can do the correct function. And biologically, we think this should be an effective treatment.  [00:24:54] Nicky: Um, so we can do that in cells in a dish. We don't yet know whether we can do that in a patient with ReNU. Uh, but that's really, really promising early data. Um, so I'm very hopeful about where that, those studies might lead.   [00:25:08] Sharon: And Ana Lisa, what role will genomics continue to play in improving understanding and care for rare conditions like this?  [00:25:15] Ana Lisa: So following on from what Nicky said, I think the really big hope is that we will be able to develop many, many new treatments collaboratively across the world. And whether these are individualised treatments made for one patient but then shared because we can find perhaps other patients who could benefit from the same treatment, whether we understand the genetics better so that we can design treatments from the start that will work for a lot of patients.  [00:25:46] Ana Lisa: So I think there will be sort of fancier and fancier ways of targeting rare conditions. And right now we're in a phase where the ecosystem is trying to work out how could we make an end-to-end pathway with initiatives like the Rare Therapies Launchpad in the UK, and that's going to require truly collaborative working.  [00:26:08] Ana Lisa: No single organisation can do that. And I think having these incredible use cases will be really powerful for turbocharging the development of these pathways. And the hope is that once you've worked out how to do this across a range of different rare conditions, that one might reach a stage where one could do that a lot faster for many other rare conditions.  [00:26:35] Ana Lisa: Because at the moment they're so underserved in terms of treatments available and there's a huge gap between being able to make a genetic diagnosis and then having treatments. The big hope is that understanding the genetics better will help to open up new pathways to treatment. I do hope that we'll also understand other aspects.  [00:27:02] Ana Lisa: So for example, it might be that understanding the genetics better also helps us to understand different ways a condition might manifest in somebody, why it may be different from one person to another, why somebody might be more mildly affected and somebody perhaps more severely. And that might, may also help us to understand ways to treat a condition by getting, gaining these insights which are, are useful in and of themselves and may also lead to new therapeutic, uh, possibilities.  [00:27:36] Ana Lisa: I think that would be one of my hopes that a lot of these areas overlap and lead to real benefit for patients and families, that we can translate that hope into concrete improvements in treatment for rare conditions.  [00:27:57] Sharon: Do you have a sense of time, how long you think this could all take, that amount of collaboration?  [00:28:06] Ana Lisa: Yeah, and I think this is actually another reason why sometimes it's quite tricky to make progress in this area because being able to predict those timelines is notoriously difficult when you look back historically. I'd like to hope that we're on the cusp of having an explosion of novel treatments that can target DNA and RNA, for example, or treatments that target something in the underlying biology that we now understand that we didn't before.  [00:28:34] Ana Lisa: And I do think that there is going to be a big shift. But I think that the sort of confidence intervals around how big that range of time might be is very hard to predict. And that's why I think Christina and Nicky being able to share these stories and about their collaborative working really shines a spotlight on, on what could be done and how progress can happen.  [00:29:02] Ana Lisa: That's really exciting. The other day at a conference, someone from industry stood up and said, "Oh, actually, we set up a clinical trial in the UK because we knew there were patients who could benefit from our work in the National Genomic Research Library," and that was really exciting for us because that's what we want to do; move forwards the opportunities for treatment for patients.  [00:29:28] Sharon: And so finally, Christina, as a parent and member of this community, what are your hopes for the future, and what would you say to families who may still be searching for answers today?   [00:29:39] Christina: It is a long journey, but there is the support and the help out there. If you have any inclination that you think you might have ReNU, reach out to your paediatrician or your doctor to see if you can get your genetic testing done because it's fighting to get the test, to go to people and say, "I think this is what we may have. Can we look into getting it tested?" And reach out to other families and the website and things because it's all about community and supporting and helping people find that diagnosis.   [00:30:16] Sharon: Thank you, Christina, and we'll put the website in the episode description. A huge thank you to Professor Nicky Whiffin, Christina Cox, and Dr. Ana Lisa Tavares for joining me today and sharing their insights and experiences. To learn more about ReNU Syndrome, visit renusyndromeuk.org. If you'd like to hear more stories about the people, research, and discoveries helping to shape the future of healthcare, subscribe to Behind the Genes on your favourite podcast app.  [00:30:45] Sharon: Thank you for listening. I've been your host, Sharon Jones. Behind the Genes is produced by Deanna Barac, Florence Cornish, Sophie McLachlan, and Katie Revell at Bespoken Media. 

Leta 2020 se je končal čezmejni evropski projekt »CLAUSTRA +« med hrvaškimi in slovenskimi dediščinskimi in v sodobno podobo turizma usmerjenimi ustanovami. Šlo je za poskus trasiranja dostopnih delov 17 stoletij stare poznoantične zapore Claustra Alpium Iuliarum, ki je potekala od Kvarnerja do doline Soče. Na novinarski predstavitvi takrat nove pohodniške poti ob tako imenovanem Ajdovskem zidu nad Vrhniko smo se pogovarjali z vodjo projekta, arheologinjo dr. Katharino Zanier, ki je takrat zastopala nosilca projekta Zavod za varstvo kulturne dediščine Slovenije in pozneje postala predstojnica Katedre za arheologijo na ljubljanski Filozofski fakulteti. Na terenu pa je bil tudi njen kolega iz Narodnega muzeja Slovenije dr. Jure Kusetič. Posebnost tega zidu, ki ni bil limes – starorimska zapora meja imperija od tretjega stoletja pa do propada v petem – kot na primer Hadrijanov ali zid ob Renu oziroma ob Donavi, temveč je šlo za nekaj, kar je cesarski Rim postavil znotraj takratne X. regije Venetia et Histria, torej na pragu vstopa v osrednji del države. Zakaj se je to dogajalo, je na začetku pojasnjeval arheolog dr. Jure Kusetič. FOTO: Območje poznorimske zapore znotraj Regio X. je označeno na zemljevidu imperija VIR: https://sl.wikipedia.org/wiki/Claustra_Alpium_Iuliarum#/media/Slika:Claustra_Alpium_Iuliarum.jpg

Welcome back Rana McKay! Renu was on a flight to Europe this week so Rana jumped into her seat in the GU Cast studio this week to have a chat about the intriguing ARASEC trial which she presented at the AUA Annual Meeting recently. Plus her thoughts on the ARACOG data presented at ASCO last month. And then a great chat with our other studio guest, Professor Renea Taylor, translational scientist at Peter Mac and Monash University, about the very interesting Early Onset Prostate Cancer project, an international collaboration which herself and Rana are both very involved with, looking at the reasons behind why younger men are turning up with aggressive prostate cancer. This is a Themed Podcast supported by our Gold Partners, Bayer Pharmaceuticals. Even better on our YouTube channelLinks:ARASEC trial at AUA 2026 ARACOG trial at ASCO 2026 

El que mantiene su mente abierta para aprender, descubrirá que la vida nunca se estanca y siempre se renueva.

IANR 2626 062726 Line Up4-6pm INTERVIEWSHere's the guest line-up for Sat, June 27, 2026 from 4 to 6pm CST on Indo American News Radio (www.IndoAmerican-news.com), a production of Indo American News. We are on 98.7 FM and you can also listen on the masalaradio app.By Monday, hear the recorded show on Podcast uploaded on Spotify, Apple Podcasts, Pocket Casts, Radio Public and Breaker or go to our website and click on the IANR link. OurPodcast has been rated #2 among 100 Podcasts in Houston by feedspot.com and rated in the Top 20 Apple Podcasts in 13 countries by Podstatus.com. In 6 years and with over 1200 Podcasts, we have had thousands of hits.TO SUPPORT THE SHOW, SELECT FOLLOW ON OUR FREE PODCAST CHANNEL AND YOU'LL BE NOTIFIED OF NEW UPDATES.4:20 pm Freddy Guerra serves as Director of Government Affairs for Harris County Precinct 4, where he works to build partnerships that improve the lives of residents across one of the nation's fastest-growing regions. His work focuses on bringing together local governments, schools, nonprofitorganizations, business leaders, and state and federal agencies to advance infrastructure investments, strengthen community services, expand economic opportunity, and address regional challenges that no single organization can solve alone. He joins us today in the studio to tell us more.4:50 pm The International Day of Yoga was celebrated on the Summer Solstice last Sunday, June 21, and has grown into aworldwide phenomenon attracting thousands of people. Now in its 12th year, the event drew in many enthusiasts at over 30 events citywide and in Austin. To tell us how the month-long activities and events went, we are joined by ardent yoga practitioner and instructor and Facilitator of the Discovery Green event, Saumil Manek.  He is also a versatilesinging bowls artist who performs every Wednesday at the Buffalo Bayou Cisterns.5:20 pm We turn now to our favorite psychic, Miss Renu, from Bangalore, who made a prediction late last year that come this March, all hell was going to break loose as the world would come to war and hard times would follow. Well, she was right on target as the Middle East war drones on and prices have soared for all sorts of goods. We turn to her again today to hear what she has to say about the rest of the year and also hear from listeners who want her predictions of their problems. Miss Renu calls in LIVE from Bangalore - at 4:50 in the morning - to give her predictions for 2026, what you should do and what not to do.Also stay tuned in for news roundup, views, sports and movie reviews.TO BE FEATURED ON THE SHOW, OR TO ADVERTISE, PLEASE CONTACT US AT 713-789-NEWS or 6397 or at indoamericannews@yahoo.comPlease pick up the print edition of Indo American News which is available all across town at grocery stores. Also visit our website indoamerican-news.com which gets 90,000+ hits to track all current stories.And remember to visit our digital archives from over 18 years.  Plus, our entire 45 years of hard copy archives are available in the Fondren Library at Rice University.

Hot topics in a hot city!! Declan and Renu escaped from deep Winter in Melbourne and landed into the hottest day on record in Berlin!! We are here to help with the Astellas Global Prostate Cancer Masterclass, a wonderful two day meeting focussing on advanced prostate cancer. Delegates from all over the world and a top class local and International faculty. We catch up with great friends of GU Cast Stephen Freedland (Cedars-Sinai Medical Centre, Los Angeles) and Bertrand Tombal (UC Louvain, Brussels), to pick their brains on hot topics in this hot city.This is a Themed Podcast supported by our Platinum Partner, Astellas.Even better on our YouTube channel

Renu had been to an excellent Bayer Apex meeting in Europe in the past, so was very happy to hear Apex was coming to us for its first Asia-Pacific outing! A wonderful prostate cancer Faculty headlined by Neal Shore, Dan George, Derya Tilki, Fred Saad, Amit Bahl, Tamim Niazi to name but a few, plus almost 200 delegates from across the APAC region. Your usual hosts Renu Eapen and Declan Murphy catch up with some of the speakers and bring you conference highlights.This is a Themed Podcast, supported by our Gold Partner, Bayer Pharmaceuticals.

Breaking News podcast just after the long-awaited PROTEUS trial reads out at the ASCO Plenary in Chicago! Plus a simultaneous NEJM paper! Huge day for prostate cancer surgery. Declan and Renu are joined by lead author Dr Mary-Ellen Taplin (Dana Farber Cancer Institute & Harvard University), to tell us about her decades long journey to this huge moment today. PROTEUS is a huge (2,100 men) phase III RCT of men undergoing radical prostatectomy for high-risk prostate cancer, randomised to receive peri-operative ADT + placebo, or ADT plus apalutamide. Mary-Ellen talks to us about the top-line results, and we consider whether this is truly a practice-changing study. Declan also had the honour of being the Discussant at teh ASCO Plenary so he is well placed to give his opinion. Your usual hosts are Declan Murphy & Renu Eapen. Even better on our YouTube channel This is a Themed Podcast supported by our Gold Partner, Johnson & Johnson.Links:PROTEUS NEJM paper

Jeebanrakshya 2083-01-14 Dr Renu & Suraj Final

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Our biggest live show to date! Taking to the huge eUro 2 auditorium at this month's EAU Annual Meeting in London, Declan and Renu bring you a fast-paced, high-energy session packed with favourite guests, controversial topics, behind-the-scenes stories, and lots of great giveaways, all boosted by having hundreds of our loyal supporters there in the audience with us.Huge thanks to Maarten Albersen and all at the EAU Scientific Office for this invitation, and to everyone at MediAVentures, M-Events, Congress Consultants, Soma Studios and CMDM Media for helping us put it together. And to our own team including David Chen, Carlos Delgado, and Elena Berg for their help and for being with us in London.This one for sure best enjoyed on our YouTube channel

It is the eve of the USANZ ASM here in Melbourne (which Renu is Convening!), and some of the 27 International guests are already into town. So we grabbed Anders Bjartell (Lund University/University Hospital Malmo, SWE), for a sit down chat in studio. Anders has been a huge name in prostate cancer research in Europe for the past couple of decades, including as a senior investigator on TITAN. so we decided to pick his brain on three topical areas in prostate cancer:1. ADT/ARPI doublets in mHSPC - can we adopt an intermittent approach before the trials read out? What about docetaxel triplet therapy?2. The SPARC consensus on PSMA PET/CT reporting - Anders led this initiative which recently publihsed in Eur Urol. What is this and why does it matter?3. Organised Prostate Testing - what is the difference between screening and organised prostate testing? With usual hosts Renu Eapen and Declan MurphyThis is a Themed Podcast supported by our Gold Partners, Johnson & Johnson. Links:SPARC consensus paper in European Urology 

What if the biggest risk to your marketing AI strategy isn't the technology itself, but the org chart it's fracturing?Agility requires more than just speed; it demands a framework of trust and collaboration. When it comes to AI, this means your ability to innovate is directly tied to your ability to partner effectively across the organization, especially with IT and security.Today, we're going to talk about a critical tension point in the modern enterprise: Marketing is moving at the speed of AI, adopting powerful, often low-code tools to drive results. But this speed creates new complexities and risks, disrupting traditional roles and processes. Success is no longer just about having the best tech stack; it's about forging a strategic partnership between the CMO and IT leaders to balance innovation with governance, and productivity with security.To help me discuss this topic, I'd like to welcome, Renu Upadhyay, Chief Marketing Officer at Omnissa. About Renu Upadhyay Renu Upadhyay is SVP & CMO at Omnissa, leading global marketing strategy, demand generation, product and solution marketing and brand to establish Omnissa as the leading digital work platform company. Renu is an experienced technology marketer with a deep understanding of products, industry, and customers spanning mobile, wireless networking and collaboration solutions across large and mid-size organizations. Prior to Omnissa, she served as vice president of Marketing for VMware's End-user Computing (EUC) business. In that role, she led marketing strategy and was responsible for customer messaging, demand, content marketing, sales and technical enablement, and product pricing strategy. She oversaw marketing programs and campaigns for EUC's comprehensive portfolio of solutions including employee engagement programs. Prior to VMware, Renu held senior product marketing roles at leading companies including Good Technology, Cisco Systems and AT&T Wireless. Renu Upadhyay on LinkedIn: https://www.linkedin.com/in/renuupadhyay/ Resources Omnissa: https://www.omnissa.com/ Take your personal data back with Incogni! Use code AGILE at the link below and get 60% off an annual plan: https://incogni.com/agile The Agile Brand podcast is brought to you by TEKsystems. Learn more here: https://www.teksystems.com/versionnextnow Catch the future of e-commerce at eTail Palm Springs, Feb 23-26 in Palm Springs, CA. Go here for more details: https://etailwest.wbresearch.com/Drive your customers to new horizons at the premier retail event of the year for Retail and Brand marketers. Learn more at CRMC 2026, June 1-3. https://www.thecrmc.com/ Enjoyed the show? Tell us more at and give us a rating so others can find the show at: https://advertalize.com/r/faaed112fc9887f3 Connect with Greg on LinkedIn: https://www.linkedin.com/in/gregkihlstromDon't miss a thing: get the latest episodes, sign up for our newsletter and more: https://www.theagilebrand.showCheck out The Agile Brand Guide website with articles, insights, and Martechipedia, the wiki for marketing technology: https://www.agilebrandguide.com The Agile Brand is produced by Missing Link—a Latina-owned strategy-driven, creatively fueled production co-op. From ideation to creation, they craft human connections through intelligent, engaging and informative content. https://www.missinglink.company Hosted on Acast. See acast.com/privacy for more information.

What if the biggest risk to your marketing AI strategy isn't the technology itself, but the org chart it's fracturing? Agility requires more than just speed; it demands a framework of trust and collaboration. When it comes to AI, this means your ability to innovate is directly tied to your ability to partner effectively across the organization, especially with IT and security. Today, we're going to talk about a critical tension point in the modern enterprise: Marketing is moving at the speed of AI, adopting powerful, often low-code tools to drive results. But this speed creates new complexities and risks, disrupting traditional roles and processes. Success is no longer just about having the best tech stack; it's about forging a strategic partnership between the CMO and IT leaders to balance innovation with governance, and productivity with security. To help me discuss this topic, I'd like to welcome, Renu Upadhyay, Chief Marketing Officer at Omnissa. About Renu Upadhyay Renu Upadhyay is senior vice president of Marketing at Omnissa, leading global marketing strategy, demand generation, product and solution marketing and brand to establish Omnissa as the leading digital work platform company. Renu is an experienced technology marketer with a deep understanding of products, industry, and customers spanning mobile, wireless networking and collaboration solutions across large and mid-size organizations. Prior to Omnissa, she served as vice president of Marketing for VMware's End-user Computing (EUC) business. In that role, she led marketing strategy and was responsible for customer messaging, demand, content marketing, sales and technical enablement, and product pricing strategy. She oversaw marketing programs and campaigns for EUC's comprehensive portfolio of solutions including employee engagement programs. Prior to VMware, Renu held senior product marketing roles at leading companies including Good Technology, Cisco Systems and AT&T Wireless. ,Yes,This will be completed shortly Renu Upadhyay on LinkedIn: https://www.linkedin.com/in/renuupadhyay/ Resources Omnissa: https://www.omnissa.com/ Take your personal data back with Incogni! Use code AGILE at the link below and get 60% off an annual plan: https://incogni.com/agile The Agile Brand podcast is brought to you by TEKsystems. Learn more here: https://www.teksystems.com/versionnextnow Catch the future of e-commerce at eTail Palm Springs, Feb 23-26 in Palm Springs, CA. Go here for more details: https://etailwest.wbresearch.com/Drive your customers to new horizons at the premier retail event of the year for Retail and Brand marketers. Learn more at CRMC 2026, June 1-3. https://www.thecrmc.com/ Enjoyed the show? Tell us more at and give us a rating so others can find the show at: https://advertalize.com/r/faaed112fc9887f3 Connect with Greg on LinkedIn: https://www.linkedin.com/in/gregkihlstromDon't miss a thing: get the latest episodes, sign up for our newsletter and more: https://www.theagilebrand.showCheck out The Agile Brand Guide website with articles, insights, and Martechipedia, the wiki for marketing technology: https://www.agilebrandguide.com The Agile Brand is produced by Missing Link—a Latina-owned strategy-driven, creatively fueled production co-op. From ideation to creation, they craft human connections through intelligent, engaging and informative content. https://www.missinglink.company

Así como la serpiente engañó a Eva por los sentidos (2 Co 11:3), hoy el mundo nos programa con ideas que moldean identidad y hábitos. Levanta el escudo de la fe (Ef 6:16) y renueva tu mente (Ro 12:2): vuelve a tu identidad en Cristo (aceptado, seguro, significativo) y deprograma pensamientos que no vienen de Dios. Pasos: corta una entrada nociva, reemplázala con Palabra (lee y escribe una verdad y una acción), responde a cada dardo con un versículo, y actúa acorde a “Soy hijo de Dios”. Quizá no “encajes”, pero vivirás libre y firme.

Bichula welcomes Chuy the Podcaster to discuss a well-known classic movie by Alfred Hitchcock, Psycho. Sources—> Flitterman-Lewis, Sandy. "Psychoanalysis, Film, and Television." Channels of discourse: Television and contemporary criticism (1987): 172-210. PDF download.Mondal, Subarna. “‘Did He Smile His Work to See?'—Gothicism, Alfred Hitchcock's Psycho and the Art of Taxidermy.” Humanities & Social Sciences Communications, vol. 3, no. 1, 17044, 2017, https://doi.org/10.1057/palcomms.2017.44.Mukhiya, Renu. Failure of American Materialistic Culture in Alfred Hitchcock's Psycho. Diss. 2016. https://elibrary.tucl.edu.np/ JQ99OgQIizUxyjI9nB0on9OyLkqsGIf4/api/core/ bitstreams/31e85404-523a-4009-8bcb-6315fa6748ec/contentRebello, Stephen. "Alfred Hitchcock and the making of Psycho." (2010). https://www.google. com/ books/edition/Alfred_Hitchcock_and_the_Making_of_ Psych/slQbvBz8YNwC? hl=en&gbpv=1&pg=PT20&printsec=frontcover

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An exclusive behind-the-scenes look at the world-famous ORSI Academy in Belgium! Declan and Renu travelled to this remarkable facility just outside Ghent in Belgium, jammed full of tens of millions of dollars worth of robotic surgery technology from the world's top providers - Intuitive Surgical, Medtronic, Microport and more. Every day, surgeons from all around the world are getting hands-on experience using the latest robotic surgery technology in an array of training environments. Plus ORSI Academy hosts many academic programs, live surgery events, telesurgery demonstrations, and is actually expanding to do even more! We get a superb tour of the building hosted by Urologist, Dr Ruben de Groote, who also tells us about Surgquest, the digital arm of ORSI Academy, which hosts an incredible library of surgical education videos, and we also chat with ORSI Academy founder and CEO, Dr Alex Mottrie, world-renowned urologist and pioneer of robotic surgery. Plus we hear first hand from senior Urology Fellows, Dr Edoardo Beatrici, and Dr Mario de Angelis, about how the ORSI Academy proficiency-based progression training works in practice. This one much better enjoyed on our YouTube channel! Links:ORSI Academy Surgquest 

Autoimmune diseases can feel isolating and unpredictable, but yoga offers both science and hope. I sit down with yoga therapist and researcher Renu Jain to explore how stress, the gut, and the immune system are connected; and how personalized yoga, pranayama, and mindfulness can support healing from the inside out.Episode Highlights:Introduction to guest Renu Jain and her background at Kaivalyadhama.Understanding what autoimmune diseases are and how they affect the body.Exploring common shared patterns and root causes behind autoimmune conditions.Exploring the connection between stress, the gut, and immune function.Understanding the pranic system and how energetic imbalance mirrors physical symptoms.The role of yoga in managing autoimmune conditions holistically.Importance of personalization in yoga therapy: why no one-size-fits-all approach works.Go-to questions yoga teachers should ask students before planning a practice.Pranayama practices that support balance and calm for autoimmune health.Restorative yoga, relaxation, and mindfulness as healing tools.How meditation helps regulate the nervous system and supports emotional healing.The mindset and empathy yoga teachers need when working with these students.Why yoga philosophy and ethics should always guide therapeutic teaching.Final reflections on patience, compassion, and using yoga as a bridge between science and spirit.Waitlist for the Online 300-Hour Yoga Teacher Training (launching January)Free upcoming workshop: “Queuing for Yoga Teachers – From Gross to Subtle” (November 14, 10 a.m. PT)Join our mailing listFind all the resources mentioned in this episodeConnect with us on Instagram

Hay etapas donde sentimos que todo se ha derrumbado —sueños, relaciones, fuerzas— y parece que ya no hay nada que rescatar. Pero cuando dejamos que Dios entre en las ruinas, Él no solo restaura… ¡hace resplandecer!

Especial sobre Salud Mental.

In this explainer episode, we've asked Dr Emily Perry, research engagement manager at Genomics England, to explain what the Genomics England Research Environment is. You can also find a series of short videos explaining some of the common terms you might encounter about genomics on our YouTube channel. You can listen to the previous episodes mentioned in this podcast How has a groundbreaking genomic discovery impacted thousands worldwide? What is the National Genomic Research Library If you've got any questions, or have any other topics you'd like us to explain, let us know on podcast@genomicsengland.co.uk. You can download the transcript or read it below. Florence: What is the Genomics England Research Environment? My name is Florence Cornish and I'm here with Emily Perry, Research Engagement Manager at Genomics England, to find out more. So Emily, before we dive into the Research Environment, let's set some context. Could you explain what Genomics England is aiming to do as an organisation? Emily: So, Genomics England provides genome sequencing in a healthcare setting for the National Health Service in England. As we sequence genomes for healthcare, the benefit is that we can also put that genomic and clinical data out for research in a controlled manner, and then that can also feed back into healthcare as well. So, it's really, this kind of cyclical process that Genomics England is responsible for. Florence: And so, what do we mean when we say Research Environment? Emily: So, the Research Environment is how our researchers can get access to that clinical and genomic data that we get through healthcare. So, it's a controlled environment, it's completely locked down, so it's kind of like a computer inside a computer. And in there, the researchers can access all of the data that we have and also a lot of tools for working with it in order to do their research. We refer to the data as the National Genomics Research Library, or the NGRL. The NGRL data is provided inside the Research Environment Florence:  So you mentioned the National Genomic Research Library. If any listeners want to learn more about this, you can check out our previous Genomics 101 podcast: What is the National Genomic Research Library? And so Emily, could you talk about what kind of data is stored in this library? Emily: So the library is made up of both genomic data and clinical data, which the researchers use alongside each other. The genomic data includes what we call alignments, which is where we match the reads from sequencing onto a reference sequence, and variants, which is where we identify where those alignments differ from the reference sequence, and this is what we are looking for in genomic research. The clinical data includes the data that was taken from our participants at recruitment, so details of the rare disease, the cancer, that they have, but also medical history data. So, we work with the NHS and we're able to get full medical history for our participants as well. This is all fully anonymised, so there's no names, there's no dates of birth, there's no NHS numbers. It's just these identifiers which are used only inside the Research Environment and have no link to the outside world. Florence: And so how is this clinical and genomic data secured? Emily: So, as I said there's no names, there's no NHS numbers, there's no dates of birth.  And we have very strict criteria for how people can use the data. So researchers, in order to get access to the Research Environment, they have to be a member of a registered institution, they have to submit a project proposal for what it is that they want to study with the data. There's also restrictions on how they can get the data out, so they do all their research inside, there's no way that they can do things like copy and paste stuff out or move files. The only way that they can get data out of the Research Environment is going through a process called Airlock, which is where they submit the files that they want to export to our committee, who then analyse it, check that it's in accordance with our rules and it protects our participants' safety and that only then would they allow them to export it. Florence: Who has access to the Research Environment? Emily: We have researchers working with the Research Environment all over the world. There's 2 kind of major groups. One of them is academia, so this will be researchers working in universities and academic institutions. The other side of it would is industry - so this will be biotech, startups, pharma companies, things like that. Florence: And finally, can you tell us about some of the discoveries that have been made using this data? Emily: There's lots of really cool things that have come out of the Research Environment.  A recent story that came out of the Research Environment was the ReNU syndrome, it was initially just one family that they identified this in, and they were able to extend this discovery across and identify huge numbers of individuals who had this same disorder because they had their genomes within the Research Environment. Florence: You can hear more about this research in our previous Behind the Genes podcast: How has a groundbreaking genomic discovery impacted thousands worldwide? So, we'll wrap up there. Thank you so much, Emily, for sharing more about what we mean by the Genomics England Research Environment. If you'd like to hear more explain episodes like this, you can find them on our website, at www.genomicsengland.co.uk or wherever you get your podcasts. Thank you for listening.  

Send us a textThis week on Three Kitchens Podcast, we welcome Renu Bhardwaj, a UK-based food blogger and author of Celebrate Diwali: Recipes, Activities, and Crafts for the Entire Family.Celebrate Diwali includes crafts, celebration tips, and of course, recipes: delicious, accessible Indian dishes that blend tradition with a modern, family-friendly approach. Renu shares her memories of learning to cook alongside her mother, and the dishes that take her right back to those regular family dinners, and annual Diwali festivals. We make one of her favourites, chole bhatura. As Renu describes it in her book: "The irresistible combination of spiced chickpeas and puffy, deep-fried bread makes chole bhatura a cherished and very popular Punjabi dish, especially at Diwali. Chickpeas are simmered and infused with aromatics and spices, and the dough needs to rest before being fried to create the pillowy bhatura, so I reserve this for special occasions like Diwali. Chole bhatura is also sure to wow guests with its layers of flavors and textures, bringing a celebratory mood and an atmosphere of joy, gratitude, and togetherness—and that crisp, hot-from-the-pan bread always tempts me into a gratifying second helping."We enjoyed making (and eating!) chole bhatura at home. The chickpeas couldn't be easier, and while the bread will take a little practice, we recommend giving it a try. It's everything Renu says it is -- warm, comforting and worthy of going back in for seconds. Ask your local bookstore for Celebrate Diwali: Recipes, Activities, and Crafts for the Entire Family by Renu Bhardwaj , or grab your copy online at Indigo or Amazon. Follow Renu on Instagram here.Get the recipe: Chole Bhatura************************************Three Kitchens Podcast - a home cooking showCheck out our website where you can listen to all of our episodes and find recipes on our blog: www.threekitchenspodcast.comYou can support the show with a small donation at Buy Me A Coffee.Want to be a gues Three Kitchens Podcast - a home cooking showCheck out our website where you can listen to all of our episodes and find recipes on our blog: www.threekitchenspodcast.comYou can support the show with a small donation at Buy Me A Coffee.Want to be a guest? We want to hear from you! Join us on our socials!Instagram @three_kitchens_podcastFacebook @threekitchenspodcastYouTube @threekitchenspodcastTikTok @threekitchenspodcastRate, review, follow, subscribe and tell your friends!

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They started off by introducing themselves as The Three Horsemen of the Apocalypse - what could possibly go wrong!! Declan couldn't resist the opportunity to invite three very eminent radiation oncologists into the studio when they all happened to be in Melbourne, even if he was particularly outnumbered while Renu was away! Vedang Murthy (Tata Memorial, India), Andrew Loblaw (Sunnybrook Hospital, Canada), and Sarat Chander (Peter Mac, Melbourne) are all highly specialised in prostate radiation, so Declan invited them into the GU Cast studio to pick their brains on three big areas in prostate radiation:1. Hypofractionation in 2025 - Who and How?2. Who needs ADT and for how long when having prostate radiation?3. Metastasis-directed therapy for oligometastatic disease - is there any point??Tune in to find out how Urologist Declan Murphy fared up against these three Radiation Oncologists!!! Even better on our YouTube channelThis podcast is supported by our Bronze Partner, Icon Cancer Centre.

Fundación Vasca Cooperante, Asociación Elkartea

Here it is, the first of our new series called GU Cast Journal Club! A dedicated GU Cast Journal Club has been suggested by many of our listeners and viewers over the years, and we are really pleased to kick off today with the first monthly episode. And we are particularly pleased to introduce our GU Cast Journal Club Editors, Dr Carlso Delgado (Melbourne, AUS), and Dr Elena Berg (Munich, GER). Declan Murphy is anchoring today's episode while Renu is busy elsewhere. Each month, two papers will be discussed, each of which are of importance to the GU Oncology community. These may be recent papers, or occasionally we will chose a classic landmark paper in GU OncologyThe objective is to draw attention to important papers in GU Oncology, and critique these in a robust mannerThe key target audience is trainees working in Urology, Medical Oncology, Radiation Oncology, Nuclear Medicine, and diagnostic specialties such as Radiology and Pathology. But any of our regular audience are likely to enjoy this Journal Club series. For this inaugural epsiode, we have selected two very important recent papers:1. Active Surveillance for Screen-detected Low- and Intermediate-risk Prostate Cancer: Extended Follow-up up to 25 Years in the GÖTEBORG-1 Trial 2. Standard or Extended Lymphadenectomy for Muscle-Invasive Bladder Cancer GU Cast Journal Club is supported by our Partner, MSD, through an unrestricted educational grant. 

In the next 25 years, the International Organization for Migration estimates that one billion people will be displaced from their homes due to climate-related events. From island nations underwater to inland areas too hot and extreme to sustain life, the individuals and communities in these areas will need somewhere new to live. Where will these people go, and how will this mass migration add further pressure to the stability of nations and the world?  In this episode, Nate is joined by environmental and migration historian, Sunil Amrith, to explore the complex history of human movement – and what it reveals about the looming wave of climate-driven migration. Sunil explains how the historical record shows migration has always been a defining feature of human life, not an exception. Together, they examine projections for future migration trends and the urgent need for acceptance, planning, and infrastructure to support the integration of new communities. What lessons can we draw from past environmental crises that forced people to move, and how do today's challenges overlap or differ? How have countries historically responded to large-scale migration, and what long-term impacts did those choices have on their stability and prosperity? Ultimately, how might a more open and welcoming mindset help us face the unprecedented migrations ahead, as well as transform them into opportunities for survival, resilience, and shared thriving? (Conversation recorded on August 14th, 2025)     About Sunil Amrith: Sunil Amrith is the Renu and Anand Dhawan Professor of History at Yale University, with a secondary appointment as Professor at the Yale School of the Environment. He is the current Henry R. Luce Director of the Whitney and Betty MacMillan Center for International and Area Studies at Yale. Sunil's research focuses on the movements of people and the ecological processes that have connected South and Southeast Asia, and has expanded to encompass global environmental history. He has published in the fields of environmental history, the history of migration, and the history of public health. Sunil's most recent book The Burning Earth, an environmental history of the modern world that foregrounds the experiences of the Global South, was named a 2024 “essential read” by The New Yorker, and a “book we love” 2024 by NPR. Additionally, Sunil's four previous books include Unruly Waters and Crossing the Bay of Bengal: The Furies of Nature and the Fortunes of Migrants.    Show Notes and More Watch this video episode on YouTube   Want to learn the broad overview of The Great Simplification in 30 minutes? Watch our Animated Movie.   ---   Support The Institute for the Study of Energy and Our Future Join our Substack newsletter Join our Hylo channel and connect with other listeners  

Listen with Irfan (LwI)A tapestry of voices and stories, spun with careSupport LwI — a soulful creation shaped by affection, thriving on the warmth of its listeners. Your contribution helps keep this free, bringing global stories, rare sound recordings, and personal music archives to all without paywalls. I curate voices, readings from literature, and cultural studies with immense care.Through my recent initiative, Read Aloud Collective, voices from around the world are coming together in celebration of spoken word.Grateful for your love -keep listening, keep supporting!  Bank Name: State Bank Of IndiaName: SYED MOHD IRFANAccount No:32188719331Branch: State Bank of India, Vaishali Sec 4, GhaziabadIFSC–SBIN0013238UPI/Gpay ID irfan.rstv-2@oksbiSupport LwI by contributing:  https://rzp.io/rzp/MemorywalaPayPal ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠paypal.me/farah121116⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Your comments and feedback are welcome. Write to ramrotiaaloo@gmail.com

Passagens Complementares:Lucas 14,33I Timóteo 6,10Filipenses 3,7-8Marcos 8,36

Nayibe Rico conversa con "María" una mujer víctima de violencia intrafamiliar.

250830 - Renuévate by Vokaribe Radio

Renu was in Taipei recently and caught up with Prof Jacob Pang, Urologist and President of the Urological Association of Asia Annual meeting which takes place in Taipei from 14-17 August 2025. Find out why you should attend in this quick pod! UAA 2025 Congress website 

250705 - Renuévate by Vokaribe Radio

250621 - Renuévate by Vokaribe Radio

In this episode, we sit down with the team from Renu MediSpa, a Hudson Valley aesthetic practice offering Botox, fillers, skin tightening, and more. We dive into how they got started, what drives their passion for helping clients feel their best, and what being a local small business means to them. Plus, we talk about our recent giveaway collaboration and their commitment to community connection.   Whether you're curious about non-surgical treatments or just love a good local business success story, this one's for you.

Orinar en espacios públicos?Los BCS en este episodio se sumergen en la profundidad de todo lo que puede suceder en espacios públicos. Tendrías relaciones sexuales en un parque ? , lasoficinas de gobierno son espacios pueblicos o son elinfierno …Renuévate y deja tu otro yo para convertirte en lapeor versión de ti, o la mejor según tu propia creatividad …te casarías en un monumento ?, cual ?

Dios nos ha llamado a ir de gloria en gloria y como resultado de la reinvención y restauración Dios nos llevará a nuevos niveles.

Renu Gidoomal is a gifted singer, composer, producer and beautiful mimicry artist who has done over 1000 concerts in more than 25 countries in the last three and half decades. She had never dreamt that one day she would be part of the Sri Sathya Sai Kids World of the Sri Sathya Sai Media Centre. How this blessing came to her is one of her life's brightest OMS moments. As she recounts that episode, she also enthrals us with her sweet mimicry - the song that was her first offering to the SSS Media Centre.

Si algo no se renueva simplemente se estanca, y Por eso la importancia de identificar que área de tu vida requiere atención para que no te pierdas de las bendiciones que traen cada temporada de tu vida. Asi que descubramos cómo, qué y cuándo renovarnos para ser todo aquello que fuimos llamados a ser.

In this episode of the Insurtech Leadership Podcast, recorded live at the InsureTech Connect (ITC) conference, host Josh Hollander sits down with Bobbie Shrivastav and Renu Ann Joseph to discuss the launch of their groundbreaking book series, Momentum. The first book,  Makers and Builders Edition, showcases ten unfiltered stories from women making waves in insurtech, from bootstrapped founders to venture-backed entrepreneurs.    Through personal narratives and powerful imagery, this series documents the journeys of women founders who are reshaping the industry's future, addressing the stark reality of the 2% venture capital funding gap, and creating pathways for the next generation of female innovators.   Key Insights:  Overview of the "Momentum" book series and its mission to amplify women's voices in insurtech Unique structured-yet-unfiltered approach to sharing founders' experiences Strategic use of visual storytelling to make complex industry narratives accessible Celebration of diverse paths to success, from bootstrapped to venture-backed founders Impact of representation on inspiring young girls in tech and insurance Personal stories of resilience, including cancer survivors and industry pioneers Building a supportive ecosystem for women in insurtech Power of physical printed books in creating lasting impact and inspiration Plans for future editions focusing on resilience, leadership, and Gen Z innovators   Key Topics Covered: - [00:10] Introduction to Momentum and its mission - [01:09] Inspirational stories and unfiltered narratives - [02:44] Unique storytelling format combining photos and personal stories - [03:33] Launch experience and community support - [04:27] Impact of physical books on next generation - [06:08] Diverse founder journeys and paths to success - [08:59] Breaking through industry barriers and challenges - [10:08] Venture funding gaps and alternative success metrics - [11:18] Future plans for amplifying more voices - [13:33] Maintaining authenticity in storytelling Notable Quotes: "My daughter was telling me, 'How many books did you print?' I said, '150.' She asked, 'Can I be the 150th person to receive the book?' She's nine, and she's truly been my inspiration for my startups." - [03:33] - Bobbie   "There is a background on their own personal journey. How did they grow up? Why did they fall into insurance? How did they pick the ideas they worked on, and what are the barriers? It's very, very personal." - [06:08] - Renu   "One of them said, 'I did it,' because she almost backed out of writing her story, thinking she wasn't there yet. I told her, 'Your story needs to be told. You will get there.'" - [10:01] - Bobbie   "Many of these women have great businesses without taking a single penny of investor money. For me, that is a success story." - [11:11] - Renu   About Our Guests: Bobbie Shrivastav is a dynamic leader in the insurance and technology sectors, strongly focusing on promoting diversity and inclusion within the industry. As co-founder of Momentum, a groundbreaking book series, she works to amplify the voices of women, founders, and innovators shaping the future of insurtech. Through her work, Bobbie is dedicated to inspiring the next generation of leaders, advocating for resilience, creativity, and leadership in insurance and technology.   Dr. Renu Ann Joseph is a passionate advocate for diversity and innovation in the insurance and technology sectors. As co-founder of Momentum, a transformative book series, she amplifies the stories of women, founders, and industry leaders shaping the future of insurtech. Renu's commitment to leadership, resilience, and creativity drives her work to inspire future generations and break barriers for underrepresented voices in the tech and insurance fields.   Resources: Bobbie Shrivastav https://www.linkedin.com/in/bobbieshrivastav/ https://beacons.ai/bshrivastav https://themomentumbook.com/   Renu Ann Joseph https://www.linkedin.com/in/renu-ann-joseph-changemaker1/ https://themomentumbook.com/     Josh Hollander https://www.linkedin.com/in/joshuarhollander/ https://www.horton-usa.com/ https://www.linkedin.com/showcase/insurtech-leadership-show/?viewAsMember=true  https://www.insurtechassociation.org/  https://innsure.org/  Mentioned Momentum: Makers and Builders  

This week we are so excited to be joined again by Dr. Renu to talk all about health and wellness and how to maximize your health through your hormones.Be sure to tune in to hear the secret sauce.For more info on how RAW Fitness can help you live life with confidence through health and fitness go to Https://Madeatrawfitness.comTo connect with us more, be sure to follow us on out social media accounts.Instagram - www.instagram.com/madeatrawfitness

This week we are so excited to be joined by Dr. Renu to talk all about health and wellness and how to maximize your health through your hormones.Be sure to tune in to hear the secret sauce.For more info on how RAW Fitness can help you live life with confidence through health and fitness go to Https://Madeatrawfitness.comTo connect with us more, be sure to follow us on out social media accounts.Instagram - www.instagram.com/madeatrawfitness

On this episode of Talk Nerdy, Cara is joined by Renu and Anand Dhawan Professor of History at Yale University and professor at the Yale School of the Environment, Dr. Sunil Amrith. Sunil is the author of five books, and we discuss his newest one, “The Burning Earth: A History.” Follow Sunil: @sunilamrith

There can be many different paths along your walk of life. It is along these roads we have chosen where we may lose sight of what our life can be sometimes.  My guest this week, the delightful & lovely Renu Mehta Cheng, aims to help her clients to reconnect with their true potential and the limitless possibilities for themselves.  Her work offers a chance to shift, transform and heal in a deeper, longer lasting way.  Clearing and openness can offer a new world to those who are ready to move forward and start a new day with a fresh perspective and deep strength within.On this guest episode, Renu and I become fast friends (we chatted for an hour before finally hitting record!) and explore a vast array of topics including spiritual awakenings, what happens when a soul is on a healing journey, why we have to go through the dark night of the soul and what happens when we do. Renu tells us how we can utilize the Akashic Records and Energy Healing to transform our lives in the here and nowand how you can work with the akashic and energetic Realms , the energy in your body, and the blocks you are holding in your energy field. She also explains how working with the Akashic Records can help a person have a better relationship with themselves.Renu Mehta Cheng is a highly regarded spiritual teacher and energy healer with a profound understanding of the ascension process. With years of experience in the field, Renu has dedicated her life to helping individuals achieve holistic well-being and spiritual growth.Renu's journey began with her own personal transformation, which ignited a deep passion for exploring the realms of spirituality and energy healing. Through extensive training and continuous learning, she has developed a unique approach that combines ancient wisdom with modern techniques.As a spiritual teacher, Renu guides her students on a transformative path through the spiritual awakening process, empowering them to tap into their inner wisdom and discover their true potential.As an energy healer, Renu possesses a remarkable ability to channel and manipulate energy for healing purposes and she helps teach clients and students how to use energy healing to become their own best guide and healer. She works with individuals to identify and release energetic blockages, promoting balance and harmony within the body, mind, and spirit. Renu's healing sessions are known for their profound effects, leaving her clients feeling rejuvenated and aligned.When Renu isn't speaking, teaching or working with clients you can find her playing and hiking with her beautiful family.Connect with Renu here & check out here free gift:Spiritual Awakening Kit | Discover the path to awakening your true selfwww.embracetherapy.com

This week on Nation, we are talking with one of my favorite people on the planet…Cody from Glass Renu all about scratched glass. You know for a fact you will run into it. AND most of us have no idea that something can be done about it. Not only is there MAD money to be made, but also its a great insurance policy! So lets talk scratches! Need supplies? Let me know! I would love to do that for you! Text/Call: 862-312-2026 https://windowcleaner.com/?sca_ref=3020234.dl0aAoVJ1A Want a subscription to The American Window Cleaner Magazine? Here you go! https://awcmag.com/sub/ Want to get a sweet discount on Responsibid? Find that here: https://bids.responsibid.com/SignUp?promo=joshcronin