Podcasts about Truitt

In this episode of the Epigenetics Podcast, we talked with Erica Korb from the University of Pennsylvania about her work on BRD4 and the histone variant H2BE, which influences synaptic genes and neuronal activity. Dr. Korb discusses the focus of her lab, which centers on epigenetic mechanisms impacting gene regulation in neurons. Her research primarily examines histone biology and its connection to neurodevelopmental disorders, including autism spectrum disorder and intellectual disabilities. Dr. Korb expounds on the collaborative environment at UPenn's Epigenetics Institute, emphasizing how the rich diversity of research topics fosters innovative ideas and projects within the community. Reflecting on her earlier work from her postdoctoral studies, Dr. Korb discusses her first significant findings regarding the protein BRD4. This work demonstrated BRD4's role in mediating transcriptional regulation crucial for learning and memory processes. She explains how disrupting this protein's function in neurons hindered critical gene activations required for memory formation in mice. This foundational understanding opened avenues for exploring the broader implications of chromatin regulation in various neurodevelopmental conditions. Transitioning into her current research endeavors, Dr. Korb reveals how she aims to expand her focus beyond Fragile X syndrome. With her lab now investigating multiple chromatin regulators implicated in various forms of autism spectrum disorders, she describes a recent project where RNA sequencing exposed substantial overlaps in gene expression changes associated with five distinct chromatin modifiers, each contributing uniquely to neuronal function while collectively demonstrating sensitivity to chromatin disruptions. A significant portion of the discussion centers around Dr. Korb's unexpected exploration into how COVID-19 intersects with chromatin biology through a phenomenon known as histone mimicry. Leveraging bioinformatic tools during the pandemic, her lab discovered that certain viral proteins mimic histone sequences, which may lead to altered transcriptional outputs in host cells. This coincidental finding illustrates both the creative adaptability needed in scientific research and the importance of collaborative efforts across disciplines to uncover new insights. The conversation also delves into Dr. Korb's recent work regarding the histone variant H2BE, initiated by one of her graduate students. She explains how prior research only recognized H2BE's expression in the olfactory system, yet her lab has demonstrated its significant role in regulating synaptic genes and memory formation throughout broader neuronal contexts. Notably, they identified a single amino acid change that influences H2BE's function in chromatin accessibility and gene transcription, emphasizing its potential evolutionary conservation across species. In terms of H2BE's role, Dr. Korb elucidates that its activity is integral in response to extracellular stimuli, particularly within the context of neuronal activation. Intriguingly, they found that H2BE expression decreases in reaction to long-term neuronal stimulation, suggesting a complex mechanism of homeostatic plasticity crucial for regulating neuronal activity levels. This research not only advances understanding of chromatin dynamics but also holds implications for neuronal health and disease mechanisms.   References Feierman, E. R., Louzon, S., Prescott, N. A., Biaco, T., Gao, Q., Qiu, Q., Choi, K., Palozola, K. C., Voss, A. J., Mehta, S. D., Quaye, C. N., Lynch, K. T., Fuccillo, M. V., Wu, H., David, Y., & Korb, E. (2024). Histone variant H2BE enhances chromatin accessibility in neurons to promote synaptic gene expression and long-term memory. Molecular cell, 84(15), 2822–2837.e11. https://doi.org/10.1016/j.molcel.2024.06.025 Korb, E., Herre, M., Zucker-Scharff, I., Gresack, J., Allis, C. D., & Darnell, R. B. (2017). Excess Translation of Epigenetic Regulators Contributes to Fragile X Syndrome and Is Alleviated by Brd4 Inhibition. Cell, 170(6), 1209–1223.e20. https://doi.org/10.1016/j.cell.2017.07.033 Kee, J., Thudium, S., Renner, D. M., Glastad, K., Palozola, K., Zhang, Z., Li, Y., Lan, Y., Cesare, J., Poleshko, A., Kiseleva, A. A., Truitt, R., Cardenas-Diaz, F. L., Zhang, X., Xie, X., Kotton, D. N., Alysandratos, K. D., Epstein, J. A., Shi, P. Y., Yang, W., … Korb, E. (2022). SARS-CoV-2 disrupts host epigenetic regulation via histone mimicry. Nature, 610(7931), 381–388. https://doi.org/10.1038/s41586-022-05282-z Feierman, E. R., Paranjapye, A., Su, S., Qiu, Q., Wu, H., & Korb, E. (2024). Histone variant H2BE controls activity-dependent gene expression and homeostatic scaling. bioRxiv : the preprint server for biology, 2024.11.01.620920. https://doi.org/10.1101/2024.11.01.620920   Related Episodes Neuroepigenetic Mechanisms and Primate Epigenome Evolution (Boyan Bonev) DNA Methylation Alterations in Neurodegenerative Diseases (Paula Desplats) The Role of Histone Dopaminylation and Serotinylation in Neuronal Plasticity (Ian Maze)   Contact Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Dr. Stefan Dillinger on LinkedIn Active Motif on LinkedIn Active Motif on Bluesky Email: podcast@activemotif.com

What seemingly always starts as a good idea turns out local control is far too often the causality.

Will the real Michael Truitt Stand up?

Let's talk an honest look at what is happening in the world of agricultural trade around the world and how we have some ground to make up

How many understand the impacts of policy makers decisions in other states that really affects your daily food consumptions.

Listen in as Jim interviews Chris Sayre

The State of Texas has paved the way for God and Silver to be used as currency, but has there path been the correct direction for where we are today? Is it just a Digital Prison?

The yoyo effect is in full action with the open and closing of the U.S. - Mexico border to feeder calves.

Jay is delivering granite and headed to Colorado which makes for interesting stories to come. We also look at the true system we have today in DC.

Another interview with Michael Truitt?

How can a state claim "States Rights" if 20% plus of their revenue comes from the Federal Government. I say they can't what say you?

After a great discussion about the U.S. prison system and the sense of pride in accomplishment we actually get into HR1.

Jim Puls interviews Michael Truitt?

Jay brings a wealth of knowledge and experience in working with government at every level and sees the limitations.

Jay Truitt gives a great explanition on how the Budget Reconciliation bill is supposed to progress through the legislative process.

USDA Sec of Agriculture Brook Rollins has just completed a visit to Nebraska and said alot of things that they were going to do. Jay Truitt says maybe the North wing of the USDA building should be gone.

Jay Truitt actually spent some time living in London so understands the UK perspective.

Part two of our conversation with Hannah Bontrager and Brigetta Truitt touches on ways to reach the next generation for Christ. Hannah and Brigetta speak to their generation and practical methods they are putting in place to see those around them find their hope and peace in Him. You don't want to miss this!

Jay brings a lifetime of experience in the world of lobbying DC to the forefront and Jay and Trent do not agree on Executive Orders by the White House.

This week on Beyond the Building, Debbie and Laura and talking with Hannah Bontrager and Brigetta Truitt, two amazing young women who are part of the God's Girls Bible study. This week is part one in a two part episode. Their stories and passion for Jesus will inspire you in your walk and reignite your hope in what God is doing in the next generation. Join us for a lively, faith filled conversation!

We need all policy makers to spend more time thinking about the unintended consequence's of their actions.

Of course, it is helpful to have the theory and principles behind inclusive marketing to give you a strong foundation for growth. I'm a big believer in learning from real-world situations and issues and hearing the voices of real people.  I often feel that these stories from real people will not only help you connect the dots and bring the theory to life for you in a more vivid way, but it also makes it easier for you to be in the lookout for areas to give special attention to when you put what you've learned about inclusive marketing into practice. In today's episode, you're going to hear my chat with Danielle Monae Truitt, who plays who plays Sergeant Ayanna Bell on Peacock's upcoming fifth season of the iconic series starring Christopher Meloni, Law & Order: Organized Crime.  Of course we talked a little bit about some interesting things related to the show – but I found so much of what Danielle had to say extremely relevant to you and your efforts on making your marketing more inclusive. We touched on authenticity, production – specifically as it relates to Black women's hair. We covered representation – and what good representation looks like (because lets face it, a lot of representation falls short). Many of the themes Danielle mentioned as it relates to Black women's hair, and what good representation looks like, were things consumers specifically spoke about as part of the representation in marketing research study I conducted. If you haven't had a look at that, no worries, I'll link it up for you in the show notes, as well as another article that covers how to do representation in marketing the right way. Get the Inclusion & Marketing Newsletter Law & Order Organized Crime Season 5 trailer Representation in Marketing Study (2021) How to do representation in marketing the right way

All animal owners need to stay tuned with the continual attack of targeted animal ownership such as deer & elk. The parallels between CWD and HPAI are stark. It is a backdoor approach to end animal ownership.

Clinical psychologist and applied neuroscientist Dr. Kate Truitt shares the powerful science behind telling your story as a method of healing from traumatic events. To access Dr. Truitt’s “CPR for the Amygdala” exercises, including mindful touch and cognitive distractions, visit Dr. Truitt’s YouTube channel or the free resources section at www.drkatetruitt.com. Her memoir “Keep Breathing: A Psychologist’s Intimate Journey Through Loss, Trauma, and Rediscovering Life” is available now. If you would like to reach out to the Betrayal Team, email us at betrayalpod@gmail.com and follow us on Instagram at @betrayalpod See omnystudio.com/listener for privacy information.

Good Enough is a company that makes Rails apps. They have quite a few products and all of them are built on Rails. Today James and Cade join the show to tell us about building a small software company with Rails. Show Notes * letsjelly.com/rails * https://goodenough.us/ Sponsors Hosting for The Ruby on Rails Podcast is provided by Fireside.fm. If you want to start a podcast and are looking for hosting, visit fireside.fm/rails (http://fireside.fm/rails) to get started. Alright, let's talk about deploying code without having a full-blown panic attack. You ever push something live and immediately regret it? Like, ‘Oh no, I just nuked the homepage'? Well, guess what—Flipper's got your back. Ship your code whenever you want, roll out features on your schedule, and if something goes sideways? Boom. Roll it back. No redeploy, no drama. Plus, you get multi-environment sync, audit history, and fine-grained permissions, so you don't wake up to a ‘WTF happened?' Slack message. Best part? Sign up at http://flippercloud.io/rails (http:flippercloud.io/rails) and get 10% off your first year. Flip the switch and chill out.

Smoot-Hawley says that tariffs will lead to another Great Depression, but is that the whole story? We dig, you can weigh in as well.

Today's guest is Truitt Taylor, diagnosed with colorectal cancer at age 31. He's owner of the design/build firm, Taylor Construction + Design, and cofounder of Beauty and the Builder, an Atlanta based non-profit organization focusing on serving the community, especially victims of sex trafficking, with skincare, self-care training, and providing essential living items and assisting with home maintenance.Colon cancer, as well as many other cancers, has been affecting more and more young people and Truitt and I talk all about that, as well as the emotional aspect of cancer, navigating fears, having a community around you, new beginnings, and so much more.Truitt is now a twelve year cancer survivor, lover of life, and a source of support and compassion for so many. I know you are going to love our conversation!ResourcesTruitt's Instagram https://www.instagram.com/w.truitt/Truitt's Email: hello@beautyandthebuilder.orgTaylor Construction + Design - www.taylorconstructiondesign.coBeauty and the Builder - www.beautyandthebuilder.orgFollow:Follow me: https://www.instagram.com/melissagrosboll/My website: https://melissagrosboll.comEmail me: drmelissagrosboll@gmail.com

Macey Truitt shares what a childlike faith looks like to her. Matthew 18:1-4

Catch up with Cheyne on IG @tradecraftphoto buy is new book "Fade into Reach"patreon.com/letstokeaboutitwww.lordbongtimore.com

I we completely support the effort to support and choose the local food route. With that said who thinks local ONLY will feed the United States population let alone the world?

The jobber, the oil company all the above are living on the backs of the farmer in the fuel market. Hey look the farmer who still owns part of the ethanol plant can't even buy fuel for his own use. We need reform.

So have you thought about the energy requirements of food production from Farm to Fork? It is mindboggling actually.

Jay Truitt has spent a life time in the world of understanding how the policy makers interact, or don't with the real world of production.

Distinguished psychologist and neuroscientist Dr. Kate Truitt takes her expert hat off and lets her hair down in today's candid conversation with Sarah. The bestselling author of Healing in Your Hands and the new title Keep Beathing lays bare her personal odyssey through loss and trauma as well as the key to her renewal- the realization that she wasn't the problem; her brain was. Wired from years of trauma to keep her ‘safe', “Amy the Amygdala” was actually keeping her caught in a cycle of negative, intrusive thoughts. Listen to Sarah and Dr. Kate talk about the tenacity of that cycle and how to break it. Two phoenixes in their own right, Sarah and Dr Kate get raw and real, inviting all cycle breakers to join their odyssey (Thanks to Dr. Kate, we now know that a group of phoenixes is called an odyssey!). Learn more at www.DrKateTruitt.com  

The discussion starts with coffee from El Salvador and we end up on the trade deficit and what we need to fix it ASAP. Plus the massive number of ingredients' in some of the processed foods.

Jay Truitt has spent a career as a lobbyist and weighs in today on issues in Nebraska and Colorado. A direct violation of the Constitution in about to happen in Colorado on the 2nd Amendment.

We the people have not demanded accountability for generations and now we see the results, it is not pretty.

We cover a massive amount of territory in this one conversation. Including Nebraska The Beef State and why exactly that honored is earned.

Do we fully understand the risk of the collapse of the beef industry? I am not talking about high cattle prices either, I am talking about the dwindling inventory that we are going to have a hard time in replacing.

In this episode I cover our newly published Co-Managed IT Sales Presentation. If you're currently meeting with co-managed prospects or plan to in the future, I promise this one is worth listening to! I go into detail about how we positioned Co-Managed to the different personas you may be presenting to, important talking points that MUST be included in these presentations, and WHY we included each slide. I hope this helps you close all the Co-Managed IT deals! P.S. sorry about missing last week. My wife gave birth to our third child last week. A healthy baby boy named Truitt!

Joining us on this special fifth-anniversary episode of Living Off Rentals is an attorney with over 15 years of experience helping high-net-worth individuals protect their assets and grow their wealth.  Glenn Truitt is the co-founder of Private Wealth Law, where he focuses on everything from Mergers and Acquisitions to Corporate Governance and Asset Protection.  Born in the suburbs of Chicago and growing up in Denver, Glenn is a proud graduate of the U.S. Naval Academy (graduating 8th in his class) and served as a Ballistic Missile Submarine Officer in the Navy before earning his law degree from Stanford Law School.  In this episode, Glenn breaks down the corporate governance strategies that real estate investors need to know. From choosing the right LLC structure to understanding Series LLCs and Family Limited Partnerships, Glenn shares tips to help you reduce your risk while saving time and money in the long run. If you're serious about protecting your investments, this is an episode you don't want to miss. Listen and enjoy the show! Key Takeaways: [03:10] Introducing Glenn Truitt and his background [08:40] Common Misconceptions for Business Law for Real Estate Investors [15:56] About piercing in real estate [25:11] Series LLC vs Individual [36:37] Glenn's recommendations on the best way to partner in business [42:00] Unsaid expectations, pre-planned problems [48:18] Family Limited Partnership (FLP) [54:33] Connect with Glenn Guest Links: Website: https://privatewealthlawinc.com/  Email: gtruitt@privatewealthlawinc.com The ABCs of LLCs: https://privatewealthlawinc.com/insights/#papers  Show Links: Living Off Rentals YouTube Channel – youtube.com/c/LivingOffRentals  Living Off Rentals YouTube Podcast Channel - youtube.com/c/LivingOffRentalsPodcast  Living Off Rentals Facebook Group – facebook.com/groups/livingoffrentals  Living Off Rentals Website – https://www.livingoffrentals.com/  Living Off Rentals Instagram – instagram.com/livingoffrentals  Living Off Rentals TikTok – tiktok.com/@livingoffrentals   

California continues to be the course study on how not to manage a state with great resources.

Broadcasting from the National Western Stock Show and Rodeo.

Jay Truitt spent 34 years as a Lobbyist in the Nations Capitol is an very qualified to make an observation about the changes in DC over the year.

If Trump only accomplishes one thing as President for me it would be to fix the massive problem we have with the military.

Dr. Kate Truitt is a psychologist and neuroscientist, visiting the show for the second time. In this episode, she opens up about being childless in our current culture and shares personal stories that have shaped her life. She also discusses her research on the amygdala and a healing method called Brain Partnership.More About Dr. TruittCEO & Founder, Dr. Kate Truitt & AssociatesCEO, Trauma Counseling Center of Los AngelesCEO & Founder, The Amy Research FoundationExecutive Director & Founder, The Truitt InstituteYouTube Channel: Empowering Brain Smart Mental Health for AllHealing Workbook: Healing in Your Hands: Self-Havening Exercises to Harness Neuroplasticity, Heal Traumatic Stress, and Build ResilienceNew book! Keep Breathing: A Psychologist's Intimate Journey Through Loss, Trauma, and Rediscovering LifeIf you're interested in seeing or buying the furniture that Paul designs and makes follow his IG for his woodworking which is transitioning from @MIHHfurniture to its new handle @ShapedFurniture WAYS TO HELP THE MIHH PODCASTSubscribe via iTunes. It costs nothing. It's extremely helpful to have your subscription set to download all episodes automatically. https://itunes.apple.com/us/podcast/mental-illness-happy-hour/id427377900?mt=2Spread the word via social media. It costs nothing.Our website is www.mentalpod.com our FB is www.Facebook.com/mentalpod and our Twitter and Instagram are both @MentalpodBecome a much-needed Patreon monthly-donor (with occasional rewards) for as little as $1/month at www.Patreon.com/mentalpodBecome a one-time or monthly donor via PayPal at https://mentalpod.com/donateYou can also donate via Zelle (make payment to mentalpod@gmail.com)To donate via Venmo make payment to @Mentalpod See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Merry Christmas to all from Jay Truitt and Trent Loos. Thank you Jesus for coming to earth for our Salvation.

The holidays look different this year for so many of us. With the loss of loved ones comes changes in how we approach the holidays – and navigating that grief can feel impossible this time of year. In this episode, Dr. Kate shares tools we can use to navigate grief and trauma this holiday season, like allowing your emotions to exist, fostering a sense of community, and making time for self-compassion. Guest: Dr. Kate Truitt: Clinical Psychologist, Applied Neuroscientist, and the author of “Healing In Your Hands” and “Keep Breathing” https://drtruitt.com/ https://truittinstitute.com/ https://traumacounseling.com/ --- Support this podcast: https://podcasters.spotify.com/pod/show/normalizetheconversation/support

What is the emissions status of the illegals that come into the USA? You might be surprised.

After a ton of jovial equine discussion about things gone by we cover some of the biggest concerns about our farming future.