Podcasts about devic

OUR going home to Heaven is nearer then when we began our race, it is not time to give up but to continue to persevere through daily repenting and weekly fasting believing God's word, please join us every Mondays, Wednesdays and Fridays in our Corporate Fasting, servant of the Lord Jesus,,, Tonight Elvi Zapata will share with you what God has been showing him through dreams and visions regarding the end time, what is about to happen in Israel and around World The Lord Jesus showed me in a vision that when people support this program, The Lords Hour'' He would bless them abundantly, he showed me blessings coming to people's lives from different directions, it was amazing to see what our God can do for his sons and daughters. by supporting this program, you also support, the Poor of Israel Matthew 6:20 but lay up for yourselves treasures in Heaven, where neither moth nor rust doth corrupt, and where thieves do not break through nor steal. Malachi 3:11 And I will rebuke the devourer for your sakes, and he shall not destroy the fruits of your ground, neither shall your vine cast her fruit before the time in the field,” saith the Lord of hosts. To Support IsraelPoor &Our Ministry www.thelordshour.org Donate@Treasures in Heaven, For Zelle Support Email; zapa999@msn also zapa9999@gmail.com shalom all NEW P.O BOX ,,,,,,THE LORDSHOUR  P.O BOX 6283 ASHEVILLE NC 28816   ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BASIC INSTRUCTION BEFORE LEAVING THE EARTH

This class will help you deepen your connection to goddess Parvati, followed by kirtan and meditation.

In this class, we explore stories and new ways of relating to the Deities of our lineage, followed by kirtan and meditation. A deeper connection to our Deities - these powerful, loving spiritual forces - is always available, and our relationship to them is ever-changing. Today's episode will open your heart to a greater and more expansive understanding of Shiva. Tonights Chants: Shiva Shiva Mahadeva Namah Shivaya Sada Shiva Refrain: Om Namah Shivaya Namah Shivaya Shiva Shiva Shankara Om Namah Shivaya Jaya Hara Hara Maha-dev Shiva Shiva Shankara Om Namah Shivaya

In this exciting new class rotation, we explore stories and new ways of relating to the Deities of our lineage, followed by kirtan and meditation. A deeper connection to our Deities - these powerful, loving spiritual forces - is always available, and our relationship to them is ever-changing. (Text continues below video). Today's class is all about the jolly, elephant-headed remover of obstacles Deity, Ganesh. Sangha member Chaitanya offers insights into approaching Ganesh simultaneously as a sweet, innocent child as well as an unimaginably powerful force of the universe. Ganesh being the child of Shiva and Parvati/Shakti, Chaitanya explains how befriending a child and gaining their trust is a guaranteed way to win over the affections of the mother. In this way, reaching out to Ganesh sincerely and directly (as a child would reach out to their mother) is one way to connect to Shiva/Shakti, our Inner Self, Universal Consciousness. We can also think of Ganesh as representing the wish to grow, what lineage teacher Rudi called “the most powerful force in the universe.” Like Ganesh, the wish to grow sits right in our hearts, and is a pure, innocent and unwavering longing of the heart. When we reach out to Ganesh before starting any puja or practice, we can do so with our sincere desire to grow, asking for his guidance and support. Building this connection with Ganesh will strengthen us on our journey of spiritual growth, and ultimately has the power to take us directly to union with our Inner Self.

Cullen is an Empathic Intuitive, Visionary, and Interstellar Communicator. Cullen has participated with non-ordinary states of reality with interstellar beings and Pan's kingdom since early childhood. Cullen began using energy to support the healing of others when he was four years old. Preceding the magical Findhorn Gardens in Scotland by a decade, he co-created a magical Findhorn-like Garden with the cooperation of the Devic kingdom in his own backyard at the age of seven. Cullen has focused his life on assisting the evolutionary movement of all towards unity. He joins Pia Orleane in the joy of bringing forth Laarkmaa's wisdom to the world. When Laarkmaa began communicating messages of love to Cullen and Pia, they were simultaneously stunned and excited! Years of interstellar-human communication were recorded and transcribed into the Wisdom From the StarsTM book series that includes: Conversations With Laarkmaa–A Pleiadian View of the New Reality; Remembering Who We Are–Laarkmaa's Guidance on Healing the Human Condition, and Pleiadian Manual for Accelerated Evolution & Ascension–Laarkmaa's Step-by-Step Guide. They also authored the COVR Gold Award winning book, Pleiadian-Earth Energy Astrology–Charting the Spirals of Consciousness, which brings Pleiadian guidance on navigating our lives through the use of energy rather than time! To accompany this revelatory new book, Pia and Cullen created a yearly Pleiadian-Earth Energy Calendar, showing how to navigate the spiral energy patterns of the Universe and Earthly relationships for spiritual advancement and conscious evolution. ⚡ Join us at our annual in-person Portal to Ascension Conference: https://ascensionconference.com ⚡Join us at our Glastonbury, UK Conference: https://ascensionglastonbury.com ❤️ Follow PTA on Instagram: https://www.instagram.com/portaltoascension

Compositeur, pianiste et musicologue, Karol Beffa a été élu compositeur de l'année aux Victoires de la musique classique. En 2016,  il remporte le Grand Prix lycéen des compositeurs. Historien de la littérature et des idées au CNRS, Guillaume Métayer est aussi poète et traducteur littéraire.  Une grande sœur et son petit frère partent à la découverte des chefs-d'œuvre de la musique classique et de leurs compositeurs… des histoires créées par Karol Beffa et Guillaume Métayer et illustrées par Odilon Thorel.  Dans Le Bal au clair de Lune, les deux enfants font la rencontre de Beethoven. "Des mois que Sol et Rémi rêvent du bal masqué que donnera Tante Élise dans son manoir. Ils imaginent déjà les velours et les soies, les danses et les rires de tous ces personnages venus du passé, baignés par le clair de lune. Rien à voir avec les cours de M. Devic, leur professeur, qui leur rebat les oreilles avec ce satané Beethoven ! Mais qu'a-t-il au juste de si génial ? Créée par des passionnés de musique classique, la collection Sol & Rémi offre de joyeuses aventures à lire seul ou accompagné. Chaque volume invite à découvrir de manière inédite l'œuvre d'un grand compositeur à travers une fiction illustrée, suivie d'un volet documentaire accessible aux enfants.  En scannant le QR code à la fin de l'ouvrage, le lecteur pourra accéder à des playlists en streaming, imaginées par les auteurs et les experts d'Universal Music, en lien avec le livre. L'enfant pourra ainsi prolonger le plaisir de la lecture par une exploration musicale ludique et originale. À lire accompagné dès 6 ans et seul à partir de 8 ans." (Présentation des éditions Seghers) Dans Le Mystérieux Boléro, les deux enfants font la rencontre de Maurice Ravel. "Rien ne serait arrivé si leur ballon n'avait atterri de l'autre côté du mur, chez cet étrange inconnu. «Personne ne doit déranger le maître, menace une gouvernante revêche, il travaille sur son boléro.» Un boléro ? Mais de quoi diable s'agit-il ? Une chaise ? Un chapeau ?  Dévorés par la curiosité, Sol et Rémi décident de mener l'enquête… Créée par des passionnés de musique classique, la collection Sol & Rémi offre de joyeuses aventures à lire seul ou accompagné. Chaque volume invite à découvrir de manière inédite l'œuvre d'un grand compositeur à travers une fiction illustrée, suivie d'un volet documentaire accessible aux enfants.  En scannant le QR code à la fin de l'ouvrage, le lecteur pourra accéder à des playlists en streaming, imaginées par les auteurs et les experts d'Universal Music, en lien avec le livre. L'enfant pourra ainsi prolonger le plaisir de la lecture par une exploration musicale ludique et originale À lire accompagné dès 6 ans et seul à partir de 8 ans." (Présentation des éditions Seghers)

durée : 00:51:37 - Accès direct, l'été - Partez en voyage au cœur du cosmos !

What does it mean to have a Pleidian spirituality? In this episode of Wisdom of Ages, host Ayn Cates Sullivan sits with guests Pia Orleane & Cullen Baird Smith to talk about Pleiadians, a soul group that is supportive of humanity's ongoing awakening. Pia and Cullen are interstellar communicators in touch with Devic and Star beings. Together, they communicate messages of love from a Peleaidian star being called Laarkmaa. In this merging of energies, they bring forth messages of love, hope, and peace. They have written many books and today, we are discussing their new oracle cards. Tune in to know if you have the Pleiadian DNA within you!

an extravagant mailbag, featuring talk of Canons and bulk-loading3D-printable leader-trimmers from Thingiverse:One for normal film: https://www.thingiverse.com/thing:4557581/filesABLON style, for Leica bottom-loaders: https://www.thingiverse.com/thing:1951048Gabe went to the Morrison Hotel Gallery show and met legendary rock photographers Bob Gruen and Henry DiltzJeff made a pilgrimage to the KEH brick-and-mortar store in Atlanta and came away with a Konica Auto S3 rangefinder and a 28mm Nikonos superwide lens which can only be used underwaterhe also got a lovely Canonflex R2000 on eBay, report to follow…however! the Canon Dial Rapid he bought from a guy in Portugal did not work, and the seller initially refused to pay for the return shipping. Remember, gang: eBay policy is, if a seller fails to provide means of returning the item, eBay can issue a refund without you returning the item first.finally, our interview with brilliant Toronto-based photographer Jessica Devic

This episode's a few days late, so Rolfe Tessem gave us a hard time: “Who do you think you are — Moonlighting?” YES! Here's a show worth waiting for: an extravagant mailbag, featuring talk of Canons and bulk-loading 3D-printable leader-trimmers from Thingiverse:One for normal film: https://www.thingiverse.com/thing:4557581/files ABLON style, for Leica bottom-loaders: https://www.thingiverse.com/thing:1951048 Gabe went to the Morrison Hotel Gallery show and met legendary rock photographers Bob Gruen and Henry Diltz Jeff made a pilgrimage to the KEH brick-and-mortar store in Atlanta and came away with a Konica Auto S3 rangefinder and a 28mm Nikonos superwide lens which can only be used underwater he also got a lovely Canonflex R2000 on eBay, report to follow… however! the Canon Dial Rapid he bought from a guy in Portugal did not work, and the seller initially refused to pay for the return shipping. Remember, gang: eBay policy is, if a seller fails to provide means of returning the item, eBay can issue a refund without you returning the item first. finally, our interview with brilliant Toronto-based photographer Jessica Devic

Our guest in this episode is curator, author, and educator Ana Devic. She is best known as a member of the curatorial collective What, How and for Whom (WHW). Formed in 1999, WHW is an exemplary case in the history of curatorial studies.Ana Devic is also in charge of the international study program for young artists called WHW Akademija based in Zagreb. With Ana, we'll further our exploration into other modes of engaging with artistic practice and hear about other possibilities, within and through art and politics. Her take on collectivity, as a spark rather than a value in and of itself; her emphasis on encounters and accessibility, and formal and informal modes of learning were really thought-provoking.EPISODE NOTES AND LINKSThis episode's conversation is part of the collaborative project ‘Communities of Learning, Bridging the Gap of Isolation', initiated by WHW and supported by the Culture of Solidarity Fund of the European Cultural Foundation.Ana Devic is a curator, writer, and teacher Ana Dević and a member of the curatorial collective What, How and from Whom (WHW). https://www.whw.hr/novosti/index.html#Formed in 1999, the curatorial collective What, How and for Whom (WHW) is an exemplary case in the history of curatorial studies. They were one of the pioneer groups who were influential in saving curatorial practice from going obsolete in a moment in which author curators (often white and male) reluctant to operate in plural forms were dominating the field of contemporary art. It's members are Ivet Ćurlin, Ana Dević, Nataša Ilić, Sabina Sabolović and designer and publicist Dejan Kršić. Based in Zagreb, WHW Academija is an international study program for young artists. The tuition-free academy takes up to 12 fellows per year intending to work on new forms of self-determination based on modes of critical reflection, curiosity, and encounters among artists, artworks, arts professionals, scholars, and practitioners. This program consists of a series of intensives, experimental exercises, workshops, and seminars, as well as a range of exhibitions, performances, and other forms of discursive programs. http://whw-akademija.whw.hr/about-whw/IRWIN is a highly influential artist collective, whose paintings, actions and installations played a crucial role in Balkan and Eastern European conceptual art, especially in the definitive era of 90's and the Post-Yugoslavian context. They were a part of NSK, along with the legendary band Laibach. https://www.irwin-nsk.org/about/Gezi Park Protests occurred in Turkey in 2013 to contest the urban development plan for Istanbul's Taksim Gezi Park. https://creativetimereports.org/2013/06/14/here-we-are-the-imagination-of-public-space-in-gezi-park/Christine Tohme is a curator and the founding director of Ashkal Alwan. The Home Workspace Program is a tuition-free annual arts study program targeting emerging artists and cultural practitioners wishing to develop their critical skills and practice in a supportive environment in Beirut. https://ashkalalwan.org/about.php#Mladen Stilinović (1947-2016) was a conceptual artist and one of the leading figures of the so-called "New Art Practice" in Croatia.Sanja Iveković is a photographer, performer, sculptor and installation artist.Tomislav Gotovac (1937-2010) was a film director, actor, performer, multimedia and conceptual artist.Goran Trbuljak is a cinematographer, photographer and conceptual artist.Decolonizing Architecture Art Research (DAAR) is an artistic practice situated between architecture, art, pedagogy and politics in the struggle for justice and equality http://www.decolonizing.ps/site/about/Alessandro Petti is an architect and researcher. He is one of the cofounders of DAAR.Sandi Hilal is an architect and researcher. She is one of the cofounders of DAAR.Conducted by Sandi Hilal and Alessandro Petti, The Tree School is a place where people can gather for communal learning and the production of knowledge grounded in lived experience and connected to communities. http://www.decolonizing.ps/site/the-tree-school/The artist group Etcetera Collective, was founded by Loreto Garín Guzmán and Federico Zukerfeld in 1997. In 2005 they founded Fundación del Movimiento Internacional Errorista (International Errorist Movement Foundation) with other artists and activists which seeks to consolidate error as a life philosophy.Known for his seminal pedagogical work Deschooling Society, Ivan Dominic Illich (1926 - 2002) was a priest, theologian, philosopher, and social critic.The Alternative Art School (TAAS) is an affordable learning program run by a stellar faculty offering intimate class sizes. TAAS emphasizes group work, community building, and dynamic modes of socializing and art-making. www.thealternativeartschool.net/how-it-works-1RAW Académie is an experimental residential program for the research and study of artistic and curatorial practice and thought in Dakar. http://www.rawmaterialcompany.org/_RAW_Academy?lang=enDAI ROAMING ACADEMY, is an itinerant program that fosters a variety of praxes at the intersections of art and theory (both seen as un-disciplines), and invigorates (collective) thinking, researching, performing, curating, writing, voicing, making and publishing. https://dutchartinstitute.eu/program/aboutThe Nuova Accademia di Belle Arti, "New Academy of Fine Arts", also known as NABA, is a privately run university in Milan.Marco Scotini is a curator, researcher, teacher, and writer.Decentralized Autonomous Organization (DAO) is a type of organization represented by rules encoded as a computer program that is transparent, controlled by the organization members, and not influenced by a central government.Pirate Care is a transnational research project and a network of activists, scholars, and practitioners who stand against the criminalization of solidarity & for a common care infrastructure. https://pirate.care/pages/concept/Memory of the World/Public Library is a case for the institution of public library and its principle of universal access to knowledge. https://www.memoryoftheworld.org/blog/2015/05/27/repertorium_public_library/Curated by WHW in 2014, “Really Useful Knowledge” was an exhibition that had taken place at Reina Sofia, Madrid which sought to highlight the collective utilization of public resources, activities, and experiments, either forgotten or under threat of eradication, taking the museum as a pedagogical site devoted to the analysis of artistic forms interconnected with actual or desired social relations. https://www.museoreinasofia.es/en/exhibitions/really-useful-knowledgeNato Thompson is an author, curator, and self-proclaimed “cultural infrastructure builder”. Nato was also the guest of Ahali Conversations Episode 18: https://www.ahali.space/episodes/episode-18-nato-thompsonSound.xyz is a startup aiming to support recording artists to monetize their projects through NFTs. https://www.sound.xyz/PleasrDAO is a decentralized autonomous organization that purchases and collects work that is relevant to the digital and crypto culture. https://pleasr.org/terra0 is an evolving prototype built on the Ethereum network that aims to provide automated ecosystem resilience frameworks. https://terra0.org/Black Swan is an experimental digital initiative designed to eat the art world by channeling resources from established institutions to cultural practitioners. https://www.goethe.de/ins/gb/en/kul/zut/dao/dab.htmlTor, short for The Onion Router, is free and open-source software for enabling anonymous communication. https://www.torproject.orgPeter Lamborn Wilson aka Hakim Bey is an anarchist author and poet, primarily known for his concept of Temporary Autonomous Zones, short-lived spaces which elude formal structures of control. https://www.amazon.com/TAZ-Temporary-Autonomous-Ontological-Autonomedia/dp/1570271518https://theanarchistlibrary.org/library/hakim-bey-t-a-z-the-temporary-autonomous-zone-ontological-anarchy-poetic-terrorismEpisode recorded on Zoom in December 2021. Interview by Can Altay. Produced by Aslı Altay & Sarp Renk Özer. Music by Grup Ses.

What kinds of unicorns, devas, and fairies step forward for this season? The Fae and Devic realm just love any opportunity to have our attention to connect in joy and to co-manifest! Fae Whisperer, Tricia Carr, will teaches about and attunes to the magickal realm of faeries and nature devas. We chat about what kinds of cosmic and nature spirts step forward for the Yuletide season. Live readings are given toward the end and these contain messages for whomever listens at whatever time.This excerpt from a livestream is a faerie celebration!Tricia Carr is a spiritual teacher, empathic channel, multidimensional medium, certified hypnotherapist and animal telepath.--> The 2022 Intuitive Intensive Begins January 23, 2022 -- Register now!https://class.lightshineacademy.com/2022ii/--> Mystic Arts Academy with Tricia Carr, Register or Subscribehttps://triciacarrcharm.com/mystic-arts-academy/ Notes from Episode(Earth) Gnomes of Abundance and their Wood ElvesEarth Element Unicorns - pale orange, peach, salmon (Water) Undines of Crystallization and their Ice FaeriesWater Element Unicorns - ice blue, pearlescent white, violet blended with white(Air) Blustery Sylphs and their Shadow Faeries Air Element Unicorns - white with golden manes, white/grey eyes(Fire) Salamanders of Prayer, Peace, and ReleaseFire Element Unicorns - brick orange/brown, black, heather grey (soot)--> Lightshine Development Circle - A sacred place for spiritual seekers to practice giving and receiving readings.https://class.lightshineacademy.com/circle/--> Tricia Carr:www.triciacarrcharm.comhttps://podcasts.apple.com/us/podcast/charmed-life-with-tricia-carr/id1173744974https://www.facebook.com/TriciaCarrCharmhttps://www.instagram.com/triciacarrcharm/--> Join the Charmed Life Mailing List for Spirit guidance, show announcements, special offers and free giftshttps://app.convertkit.com/landing_pages/444740?v=7--> Charmed Meditation Storehttps://triciacarrcharm.com/store/--> The Lightshine PodcastiTunes https://rb.gy/txw4e8YouTube https://www.youtube.com/channel/UChZ9xJNbH9NYhGhz4nVDkVgInstagram https://www.instagram.com/lightshinespiritualacademy/--> Join the Lightshine Lab!https://www.facebook.com/groups/thelightworkerslab

Scott Morris is a Regional Vise President of sales with AURA. AURA is a digital identity theft and fraud protection company that aids in the safekeeping of your finances, personal info for you and your family and is very easy to understand and is simple to set up and is your one-stop shop when it comes to digital protection for you and yours.AURA keeps your identity safe with very extensive monitoring of your personal information, accounts, and much more. They will monitor everything and alert you in real-time to all new inquires on your credit file, like new credit cards or bank loans.I've personally used many different services in the past for my digital protection but never have I seen a company that does it all under one umbrella. AURA has gone as far as acquiring other companies to ensure a smooth and easy process in order to protect you and your family's digital fingerprint. Like identity theft protection, Financial Fraud Protection, Devic and Network Protection (VPNs), and in my opinion the icing on the cake the Family Protection.Your family can rest assured they can stay safe from malware, including viruses, ransomware, trojans and so many harmful threats that can not only cause you to have your identity stolen but also lose sleep and cause you to jump through hoops in order to fix the issue. AURA lets you set up and protect yourself and up to 10 family members all in under one plan. You'll get alerted to fraud and breaches of online accounts and credit files, plus every adult member gets $1 Million in identity theft insurance. AURA will notify you if your child's Social Security Number or online accounts have been stolen or found on the dark web.Follow my Instagram page and stay tuned and look for a link for you to get your own AURA account for you and your family.@scrolling_through_life

On this weeks episode we had the honour of sitting down with Jodie Fletcher of The Devic connection. Jodie is a spiritual guide who works with her devic connection to bring you psychic readings. What we found so fascinating in this episode is that Jodie spent two whole years bed bound due to chronic illness and is still such a ray of light. We really get into how she dealt with this and leant into her power when her body was working against her. Jodie has also kindly offered all pod listeners 20% off a reading by following the link below  https://www.thedevicconnection.com/mindset-and-me-podcast We can't wait to hear what you think. As ever every share or review means so much to us. We are truly grateful. Follow Jodie on Instagram: http://www.instagram.com/thedevicconnection Follow Kirsty on Instagram: http://www.instagram.com/kirstyraynor Follow Mindset + Me Podcast on Instagram: http://www.instagram.com/mindseetandmepodcast Join the private facebook group: https://www.facebook.com/groups/391805211788110/?ref=pages_profile_groups_tab&source_id=1557434561196014 Update Descript

Jodie has created a beautiful page just for Soulful Nourishers on her website here: https://www.thedevicconnection.com/nourishing-soulfully-podcast

Dr. Brian Weinshenker joined GG deFiebre of SRNA and Jacinta Behne of The Guthy-Jackson Charitable Foundation for an ABCs of NMOSD podcast entitled, "History, Diagnosis, and Management of NMOSD." Dr. Weinshenker began with a history of NMOSD and how the aquaporin-4 antibody was discovered as a biomarker for NMO. He discussed other diagnoses that were historically used before NMOSD was coined, and he discussed the differences between how NMOSD is understood today since Dr. Devic's first understanding of the disease. Dr. Weinshenker talked about how a diagnosis of NMOSD is made, including the clinical makeup and diagnostic tests used. Finally, Dr. Weinshenker explained the acute and long-term treatments used and symptom management for NMOSD.

Amazon India and Flipkart will likely take a hit if the consumer affairs department's proposed changes—including a ban on flash sales and curbs on scaling up private labels—get the go-ahead. Also in the programme, Byju's raises $50 million more; Facebook starts rolling out Live Audio Rooms; and Srikanth Sola, a cardiac surgeon turned entrepreneur discusses plans ahead at his venture Devic Earth.

Coming Au̇t with Liz and Eddie (EP#3 THE SPIRIT OF PACHAMAMA) clipFull episode available now! All new episode every Monday where ever you stream your podcast!Download, Subscribe and ListenLink below:https://linktr.ee/comingautpodcast/

Your host moving beyond Dawn's initial Journey to Devic's and letting her listeners know Dawn's Journey is a continuation. Your host thanking everyone for tuning in to Freedom. shecklesdivaproductions@yahoo.com www.anchor.fm.com/shecklesdivaproduces --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app --- Send in a voice message: https://anchor.fm/shecklesdivaproduces/message Support this podcast: https://anchor.fm/shecklesdivaproduces/support

durée : 00:08:16 - Circuits courts en Gascogne - La spiruline de Julie Devic à Campagne, un produit 100% made in Landes et un véritable atout santé à consommer en circuit court pour favoriser l'économie locale et booster votre organisme.

Decree to disconnect from the influences of the lower energies of the astral plane. Authored by Roger Hobday. Do not alter the wording as this will alter the intent and the purity of the decree. To Clear Astral energy interference. Repeat the following aloud a minimum 7 times with patient strong intention!! “I (state all your names), call forward my Temple of Divinity, my Divine Presence and all of my higher consciousness to embody me now. I call forward all Christ Conscious Beings to assist me now. I recognize the God/Goddess that I am, that is within me, that I am within. I call forward any quarantine healing pods that maybe required, to be brought in and automatically activated on my behalf and any inlay activations that may be required to be brought in and automatically activated on my behalf”. (Sit in this for a minute or two for the first cycle only, focus on strengthening your grounding cord and your connection to the Divine.) “I strengthen my grounding cord and my connection to the Divine Heart”. “I (state all you names), withdraw all permissions granted to or assumed by any being that connects me and any part of my consciousness to the Astral plane. I demand a complete disconnection to all astral energies or frequencies that are not in alignment with my Divine plan and free will choices. I demand the safe passage of my bodies Devic energy through the astral frequency that it may be untainted by any energy or consciousness as its frequency is stepped down into the physicality”. “I now consciously choose to exercise my Sovereign Free Will right to disconnect and to be disconnected from, any and all energies and consciousnesses that reside or are anchored in or on the Astral plane that do not honour my Divine plan and free will choices. Any part of my being that requires assistance to leave the astral plane I now lovingly hand over to the Karmic Board and my Family of light, that they may receive the assistance they require to elevate their own frequency beyond that of the astral energies”. “I request assistance from the Karmic board, my Family of Light and ascended beings to remove any and all mechanisms, attachments, implants, mindsets, belief systems, promises, vows and contracts, connected to the Astral frequencies as quickly and as gently as possible”. “This decree shall stand until I, as a being that has achieved 7th dimensional consciousness or greater, chooses to rescind this decree to assist those choosing to leave the Astral plane”. “I decree this is so now. So it is. So it is. So it is.” On the last cycle: “I call for this to be sealed, blessed and anchored in alignment with my Sovereign Free Will choice, through every part of my Being, under Universal Law.” Authored by Roger Hobday. Join us for psychic readings and healing meditations every Tuesday night at 8pm Eastern USA/NY time at IntuiTalks.com

Introduction of Dawn, a Survivor of Devic's Disease. In this interview, Dawn speaks about how she believes a car accident manifested her diagnosis. --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app --- Send in a voice message: https://anchor.fm/shecklesdivaproduces/message Support this podcast: https://anchor.fm/shecklesdivaproduces/support

In this episode, I will be talking about what our first series will be about and a brief description of what Devic's is. Also what our listeners can expect in the next episode. --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app --- Send in a voice message: https://anchor.fm/shecklesdivaproduces/message Support this podcast: https://anchor.fm/shecklesdivaproduces/support

Having troubles with your third eye or financial debt? Find out how iolite can help alleviate those struggles. If you require a little extra luck or auric cleansing, peridot is the perfect stone for such things and find out how it can assist you in finding your spiritual purpose and enhance your healing practice! This week, Lorelei dives into the Kingdom of the Devas. Learn about these incredible beings and how different planes of existence are explained through some scientific exploration. Anybody in for a little Sci-Fi fun? Sure why not!  --- Support this podcast: https://anchor.fm/3rdeyewithlorelei/support

This session was about the past lives I had in Lemuria and in the Devic realm. My Higher Self explains how early humans and animals were created and the fact that it was sometimes using principles that went against nature. It describes what Lemurian bodies were like and also about the Devic /Fairy realm. This was not a past life regression to that time, but a channeling session. where I asked my Higher Self where it came from and what the first lives were like. It would seem that this is the original Lemuria when human bodies were first being manipulated but it is possible that there were civilizations before this one that were wiped out. --- Support this podcast: https://anchor.fm/janice5013/support

Having a Masters degree in physics he was influenced by his father’s books on the Rosicrucians that then took him into yoga and also to becoming a musician and experimenting with sound and understanding what constitutes sound, that some of the great masters brought through, as with Mozart.  When invited to work with Geoffrey Hodgson, originally from England, one of the most respected clairvoyants of the 20th century, Murray’s insight and understanding of the energies and frequencies that pervade and saturate the universe - took him deeply into the unseen world of Geoffrey Hodson. That - beyond the ‘filmiest of screens’* are other agencies of a higher order - devic beings - some call them landscape angels - that have in essence been over lighting evolution since life emerged onto our planet. Healthy Skepticism and not Dogmatic Scepticism Murray also talks about skepticism and what is healthy skepticism and not dogmatic scepticism - which like religions - especially Christianity it was very dogmatic until recently - that there is now a merger of science and religion. But that science too has now become so skeptical that it too follows the traits of becoming exceptionally dogmatic.  Meaning, if you cannot see it and measure it, is not definitely not there. Albert Einstein, who Murray mentions had mystical understandings was classified as a pantheist by the British Pantheist Society according to Tim’s communications with them back in 1996. That when NZ’s Lord Rutherford split the atom, Einstein said - that “Rutherford was the first person to tunnel into God.”  Also mentioned in this interview was Nikola Tesla’s statement  “The day science begins to study non-physical phenomena, it will make more progress in one decade than in all the previous centuries of its existence.”   Well, as we know - our universities are overburdened with subject matter as it is, thus science has made no real effort as things that are invisible, are also very difficult to commercialise.  Reductionist and Mechanistic Science Murray talks about science today following a reductionist mechanical model - that by breaking down everything to its constituent parts to finally after cells we have atoms and subatomic particles. They say in the dissecting of an animal - it just works as a machine - and thus every living creature is seen as a machine. That this is actually valid - our bodies do act as machines - however the human body has been said for thousands of years, as always having a soul - or a spiritual essence. The ancient Greeks from whom much of our scientific and biological language derive from, talk of ‘psyche’ as in psychology and psychiatrist - it means ‘soul’ - yet 90% of doctors may not believe in a soul, because they do not cover this or mention it, in their many years of medical school from 7 years to 13 years.        World Soul is Mentioned  The world soul (Greek: ψυχὴ κόσμου psuchè kósmou, Latin: anima mundi) is, according to several systems of thought, an intrinsic connection between all living things on the planet, which relates to the world in much the same way as the soul is connected to the human body. Plato adhered to this idea, so did Pythagoras. However, back in 1957 in the then Soviet Union, Psychic Discoveries Behind the Iron Curtain was published in America  by Lynn Schroeder and Sheila Ostrander - this book really opened the eyes of the West - that not only were the Soviets studying psychokinesis they were researching telepathy and many other taboo subjects too. However, unknown to most, the American’s were also working on some of these hidden ‘occult’ subjects as well. Harold Puthoff and Russell Targ of the Stanford Research Institute in California - were looking at ‘Remote Viewing’ and other scientific ways to access the hidden. https://www.ourplanet.org/greenplanetfm/russell-targ-ex-cia-researcher-on-esp-and-remote-viewing Murray mentions Charles Leadbeater who was a clairvoyant who was able to, in a deep meditative state - zero down and look into the heart of the atom. ThIs is a phenomenon that is outside of scientific man’s imagination. This is where Leadbeater was able to painstakingly count the number of protons in the nucleus of different atoms.   This momentous work on describing the structure of atoms - working through the periodic table to describe how many protons certain atoms had. This is very important - because he discovered the exact number of isotopes that were not know at the time, but subsequently we have now identified isotopes that now fill exactly those slots. https://www.ts-adyar.org/content/charles-webster-leadbeater-1854-1934   Though this information too has not come out to the general public, due to MSM not wanting to delve into such data. Murray’s ranging interview then covered his time with Geoffrey Hodson   http://geoffreyhodson.com/ Here he talked about his experiments he did with sound and colour as like the book - 'Music Forms’ - tells of how clairvoyants see the profusion of colour when certain music is played, in this instance the ‘hallelujah chorus’  (listen) Devas or Landscape Angels The interview went on to cover the great energies of ‘devas' that over lighted mountain tops (as well as in certain cases natural power points on the planetary energy grid.  The books, ‘Kingdom of the Gods’ and ‘Clairvoyant Investigations’ - the latter writing, with drawings of the great beings or landscape angels that are present in NZ, over Rangitoto Island, and Ngāuruhoe, immediately behind Tongariro.  etc (Listen) It was also Geoffrey Hodson who introduced vegetarianism to NZ in 1943, because as a seer, he witnessed the dark clouds or thought forms that hung over abattoir’s and especially one giant one he saw over the huge abattoir in Chicago. This was a very enjoyable interview with Murray. It is a realm that I have a keen interest in too. There is also a follow up - coming ...

Our planet has 5 kingdoms – the Mineral kingdom, the Plant kingdom, the Devic kingdom, the Animal kingdom and the kingdom of Man. Discover the allegiance between the Mineral kingdom and the kingdom of Man that allows us to bridge the distance between where we are and Universal Truth… for the good of all.

Tragically 3 were wounded in the YouTube shooting. The YouTube shooter also took her own life after injuring the others. The name of the YouTube shooter was Nasim Ahgdam who shot 3 innocents because she Ahgdam felt she was wrongfully singled out by YouTube and their new rules for a higher standard. I also talk about my experience with YouTube and what I have seen.Sinclair Broadcasting is under fire for giving dozens of news anchors a script regarding fake news. A mashup of all the news anchors reading this is located here https://www.youtube.com/watch?v=_fHfgU8oMSo Ronda Rousey is in the news again after she made an interview very worthy of your cringe. Ronda Rousey is now a WWE wrestler and is set for a multiyear deal with the WWE. Ronda Rousey seemed to be upset when asked any MMA questions. Watch it here https://www.youtube.com/watch?v=2B3RSkM2tskA Tesla Model X crashed into a concrete divider on Highway 101 in Mountain View. The driver of the Tesla did not live through the incident. Tesla still needs to upgrade it systems and seems to be working on the issue. Tesla stated the driver had a chance to correct this but ignored or didn’t hear the alarms when the Tesla Model X sounded them. For more information on Devic’s Disease or NMO please visit https://guthyjacksonfoundation.org/spectrum/devics-disease-neuromyelitis-opticanmo-notes/ or https://my.clevelandclinic.org/health/diseases/9858-devics-disease-neuromyelitis and other sites regarding this rare disease. For more of my work please go to iTunes - https://itunes.apple.com/us/podcast/dom-b-podcast/id1313384769?mt=2 Dom B Website - http://www.dombphotography.com/ Dom B Instagram - @dombphotography Dom B Twitter - @dombpodcast Dom B Facebook (Business) - https://www.facebook.com/Dom-B-Photography-484353875094683/?ref=bookmarks Dom B Facebook Personal - https://www.facebook.com/profile.php?id=100010289703861

[intro music] Host – Dan Keller Hello, and welcome to Episode Seventy-four of Multiple Sclerosis Discovery, the podcast of the MS Discovery Forum. I’m Dan Keller. Today's interview features Dr. Markus Reindl, an Associate Professor of Neuroscience at Innsbruck Medical University in Innsbruck, Austria. We discuss autoantibodies to myelin oligodendrocyte glycoprotein, or MOG, a protein component of myelin. These anti-MOG antibodies are particularly important in pediatric demyelinating diseases. Interviewer – Dan Keller First of all, why don't you define MOG for our audience. Interviewee – Markus Reindl MOG is myelin oligodendrocyte glycoprotein, and it's a myelin protein which was discovered about 30 years ago. It is of enormous interest to people working in neuroimmunology, because it's one of the main autoantigens used in experimental models for multiple sclerosis. And about 20 to 30 years ago, a lot of people started to work on autoantibodies against MOG in the field of MS because it was suspected to be a key autoantigen. And at that time, there were a lot of papers published with somewhat contradictory results. About five years, six years ago, the interest of MOG was rediscovered again when people developed more specific assays to detect these antibodies. And surprisingly, it was found that they're not present in classical multiple sclerosis but rather in pediatric demyelinating diseases, such as acute disseminated encephalomyelitis, ADEM, or neuromyelitis spectrum disorders. MSDF And what does finding anti-MOG antibodies tell you? Dr. Reindl At the moment, it just tells you that if you have these antibodies the risk that you develop MS is minor. So it points to the direction of a different demyelinating disease, which is in most cases monophasic with a good outcome. Or if it's recurrent, it's often recurrent optic neuritis on multiphasic ADEM. Altogether, all this with a good recovery from relapse. Severe disease causes are rare. MSDF So in the early stages of MS – something like clinically isolated syndrome – does MOG tell you which direction to go in if you find it? Dr. Reindl Usually if you have a clinically isolated syndrome that fulfills the current criteria for multiple sclerosis, looking at the MRI or at the cerebrospinal fluid, it will typically be negative for MOG and autoantibodies, so it's just an exclusion criteria. If you look at the CIS [clinically isolated syndrome], whether it could go to the direction of multiple sclerosis or not, if MOG antibodies are present, the answer would be rather not. MSDF Does it fit into neuromyelitis optica, especially seronegative, where there's no anti-aquaporin-4 antibodies? Dr. Reindl Yes, it can also be observed in cases with neuromyelitis optica that are aquaporin-4 antibodies negative, particularly in pediatric cases, and often in cases that present with simultaneous optic neuritis and transverse myelitis at onset. So the classical description of neuromyelitis optica by Devic back in the 19th century would rather have been a MOG antibody positive case than an aquaporin-4 antibody positive case. And the pathology of both diseases is entirely different. So in aquaporin-4 mediated neuromyelitis optica, you have an astrocytopathy under high risk of future relapses and disease deterioration. Whereas in the case of MOG antibodies, it's often monophasic, and the recovery is much better. MSDF So it sounds like anti-MOG antibodies are not just a marker, but they're actually pathognomonic or pathogenic of the disease. Dr. Reindl This is currently under investigation. So what we know from neuropathology there are currently five cases – if I'm correct, or as far as I know – that have been analyzed for neuropathology. These were in most biopsies/autopsies where MOG antibodies were present. And their pathology was in multiple sclerosis type II pathology, which points to the direction of antibody-mediated pathology. So from a neuropathological point of view, looks like MS. If you look at the clinical criteria that are currently valid for multiple sclerosis, it's clearly not MS. If you look at the pathogenesis, this is currently under investigation. From the in vitro studies, we know that these antibodies can, of course, activate compliment. They also have an affect on oligodendrocyte cell function. In vivo models are currently ongoing, and I expect there to be more results by next year on this. MSDF What is the clinical utility at this point? Is it ready for clinical use, or what more needs to be done? Dr. Reindl I think particular people working in the pediatric field are using it more and more. Because if you look, for an example, at ADEM, earlier this year we published a study that children with ADEM that are positive for MOG antibodies they have certain features in neuroradiology but also in their clinical presentation and their clinical recovery, which could aid the clinician. In particular, in the European countries, many laboratories are now setting up assays for MOG antibodies and using it in clinical routine. What has to be done now is better development of the assay, a comparison of the assays like it has been done for aquaporin-4 antibodies, like international validation experiments. We're currently setting up such an experiment for next year, together with the people in Oxford and other centers. But, my expectation would be that this antibody would have a similar use like aquaporin-4 antibody has. Also, aquaporin-4 antibodies are more specific for a specific type of disease. MSDF You've discussed anti-MOG antibodies in terms of diagnosis. You mentioned prognosis, better course. Can they be useful for following therapy? Do the antibodies actually disappear with immunosuppression, or are they always present? Dr. Reindl The point is in the monophasic cases the antibodies disappear anyway. So, I guess in 70% to 80% of all patients – particular the pediatric patients – they have these antibodies at disease onset at high titers, and with time they disappear. They only are persistent if there is a bad recovery or if there's a recurrent disease cause, like recurrent optic neuritis would be an excellent example for this. If you look at therapies, of course, therapies like plasma exchange or corticosteroid used at high doses will lead to a disappearance or a drop of antibody titers. I think we have no really long-term experience, at the moment, because these antibodies were just discovered a few years ago, until long-term studies are ongoing. MSDF Is there any work on what triggers these antibodies; whether there's exposure of antigens, what agents may be involved—environmental, genetic, viral? Dr. Reindl This is the $100 million question. Of course, we would be happy to know it. It's the similar situation like with aquaporin-4 antibodies. Also there we still don't know it. What is particular interesting is that this is most frequently observed in children at the age under 10 years. These are children that are frequently exposed to infections – the respiratory infections and other infection – therefore it's highly likely that the underlying cause is infectious. But at the moment, as far as I know, there were a couple of studies, at least, but no real systematic study using a lot of patients and with a good epidemiological setup. MSDF If there's an infectious agent, is it that it is causing damage to myelin, which is exposing antigens, or there's some crossreactivity with the infecting agent itself? Dr. Reindl Both things I think could be possible. The animal models tell us a lot of this. This is work published by Hartmut Wekerle’s group three years ago where they discovered that in transgenic animals – animals that are transgenic for MOG T cells – gut bacteria activate these T cells that go into the brain, and then MOG is released, transported out by dendritic cells to the cervical lymph nodes. And at this stage, the antibodies are induced and built. So it's a rather secondary phenomenon, which is caused by T-cell damage and T-cell destruction. I could imagine that a similar phenomenon could also help in the human situation, particularly if you consider ADEM, which has large lesions, a lot of inflammation going on there. I think it's highly likely that antigen is released, and MOG is one of the most antigenic components of the central nervous system. MSDF So what are the big lines of research right now – two or three of them – or the big questions that people are approaching? Dr. Reindl At the moment, of course, a better developmental definition of the assay—I guess this is one of the most important—is we're working together – a lot of laboratories, a couple of groups – to improve our assays to come to a common standard and to develop an assay which could be used by different laboratories in the world. The second is, of course, to better define the clinical and neuropathological diagnosis of the patients presenting with these antibodies. Because at the moment, it's rather diffuse. You have children with ADEM, you have children with optic neuritis, children with myelitis. You have adults with NMO-like symptoms. And to put this together in a better way is, of course, highly challenging, and this is work ongoing at the moment. I think we will have more results of this by the next year. And of course, the third thing is just to look better at the long-term prognosis of these patients. How these antibodies fits in their long-term prognosis, if they are rather beneficial or not. And this is also work that only can be clarified using larger cohorts of patients and international studies. MSDF So is it fairly rare to find anti-MOG antibodies? Dr. Reindl In adults, yes. In children, no. So if you look at children presenting with demyelinating syndromes, from our own ongoing study cohort in Germany and Austria—we know it's about a third of all children presenting with demyelinating syndromes—more than a third have these antibodies. If you look at adults, it's much more rare. I guess it's about 5% or less. MSDF Well, thank you very much. Dr. Reindl You're most welcome. [transition music] MSDF Thank you for listening to Episode Seventy-four of Multiple Sclerosis Discovery. This podcast was produced by the MS Discovery Forum, MSDF, the premier source of independent news and information on MS research. MSDF’s executive editor is Carol Cruzan Morton. Msdiscovery.org is part of the non-profit Accelerated Cure Project for Multiple Sclerosis. Robert McBurney is our President and CEO, and Hollie Schmidt is vice president of scientific operations. Msdiscovery.org aims to focus attention on what is known and not yet known about the causes of MS and related conditions, their pathological mechanisms, and potential ways to intervene. By communicating this information in a way that builds bridges among different disciplines, we hope to open new routes toward significant clinical advances. We’re interested in your opinions. Please join the discussion on one of our online forums or send comments, criticisms, and suggestions to editor@msdiscovery.org. For Multiple Sclerosis Discovery, I'm Dan Keller. [outro music]

In this episode of the Mystic FM podcast Tanya Solberg takes us into the fascinating unseen world of the devic kingdom. Tanya will reveal, based on her study of Dr King's work, insights into this little known aspect of life on Earth. In this podcast you will hear: What the devas and nature spirits [...]

[intro music]   Hello, and welcome to Episode Forty-Two of Multiple Sclerosis Discovery, the podcast of the MS Discovery Forum. I’m your host, Dan Keller.   This week’s podcast features an interview with Dr. Lawrence Steinman, who discusses a surprising result involving amyloid, a molecule typically associated with destruction in Alzheimer’s disease, in an animal model of MS.   Our Drug-Development Pipeline includes continually updated information on 44 investigational agents for MS. During the past week we added 1 new trial and 16 other pieces of information. The drugs with important additions are dimethyl fumarate, daclizumab, glatiramer acetate, and natalizumab. To find information on all 44 compounds, visit msdiscovery.org and click first on Research Resources and then on Drug-Development Pipeline.   According to our curated list of the latest scientific articles related to MS, 50 such articles were published last week. To see last week’s list, go to msdiscovery.org and click on Papers. We selected one of those papers as an Editors’ Pick. It’s a meta-analysis of epidemiological studies of neuromyelitis optica, also called NMO or Devic’s disease. The conclusion of the meta-analysis is that there’s a high level of heterogeneity among the 9 studies that met the inclusion criteria. The prevalence of NMO in the studies ranged from 0.51 per hundred thousand in Cuba to 4.4 per hundred thousand in southern Denmark.   Will you be attending the annual meeting of the Consortium of Multiple Sclerosis Centers in Indianapolis next week? If so, please come visit us at the Accelerated Cure Project’s booth. We’ll be demonstrating some of our latest data visualizations along with other features of the MS Discovery Forum. You’ll find the booth in the hallway close to the main entrance to the exhibit hall, and we look forward to meeting you.   [transition music]   Now to the interview. I spoke with Dr. Lawrence Steinman, professor of neurology and neurological sciences, pediatrics, and genetics at Stanford University, who has a new twist on amyloid, this time in MS.   Interviewer – Dan Keller Dr. Steinman, you have proposed that amyloid can be a protective molecule as well as what’s commonly viewed as a destructive molecule. How did you come upon this?   Interviewee – Lawrence Steinman We came about it serendipitously or by accident. I had a graduate student and I thought I would give that student some low-hanging fruit, and the low-hanging fruit was to take the conventional animal model that we use for multiple sclerosis called experimental autoimmune encephalomyelitis – EAE. And when she put in these long peptides from an infamous protein named amyloid beta – A-beta – she put it into the animals with EAE at the time they were paralyzed, and I thought well, these are molecules that cause even more inflammation in the central nervous system, so they should make the disease worse, or perhaps they’ll have no effect and then we’ll have to think of another project for her PhD. So the student, Jacqueline Grant, came back and said, “Well, I gave the A-beta peptides and the animals are all better, they’re walking around.” And I first reacted, no, you must have confused the cages, let’s do it again. And when we did it again there was the same result, so then we were off to the races.   There was a second reason besides the low-hanging fruit description. May Han, my colleague, and I had reported the proteomics of MS lesions; so we took well-defined MS lesions, May cut frozen sections and then removed the lesion area with a laser tool, and then we trypsinized, fragmented the proteins, and used a modern technique, mass spectroscopy, to get the proteome, a list of all the proteins in the lesions. So amyloid proteins such as amyloid precursor protein and cal protein are found in the lesions themselves, so I thought that that was a second opportunity, a second foundation for doing these experiments in EAE; let’s see what happens when we augment, if you will, a naturally occurring protein found in the lesion to see perhaps what it’s doing. But, again, my bias, based on the dominant theory in Alzheimer’s disease is that amyloid was going to cause harm in MS as well as Alzheimer’s.   MSDF In these experiments, the amyloid was injected IV so it seems to circulate, but does it get to the brain in these mouse EAE models?   Dr. Steinman Actually, it does not get to the brain. We’ve actually put it into the brain directly to see if it would spread throughout the brain, and in our hands the molecules we’re working with do not spread. Most of these experiments showing a prion-like spread of amyloid is done in animals that are overexpressing the amyloid proteins in the brain so that they’re sort of tilting the balance to enhance spread if it’s going to occur, but we don’t get these amyloid molecules into the brain when we inject them intravenously, nor do we spread them around when we injected them directly into the brain.   MSDF So if you’re injecting them peripherally, do you think that there is some direct effect, or do you think they’re acting through lymphocytes or other circulating cells?   Dr. Steinman Well, we now know that there are at least two mechanisms. One is that when we are injecting them peripherally, these amyloid-like molecules, they go to sites of inflammation and this could include sites of inflammation within the brain. But remember, they’re on the vascular side of the lesion. And they act in a way like molecular sponges. The amyloid molecule is very sticky; in fact, when you try to work with some of the amyloid molecules, they’re like bricks, they stick to the walls of test tubes, and more importantly, they stick to each other and form these long, brick-like fibrils.   So what they’re doing when we put them into the circulation is they’re sopping up many of the inflammatory mediators that appear in the circulation during inflammatory diseases, including inflammatory diseases of the brain. These inflammatory mediators include the complement proteins and some of the famous apolipoproteins that we’ve heard about in reference to Alzheimer’s, we’ve heard the most about apolipoprotein E. So these amyloid molecules, when they’re in the circulation, actually stick and take away, precipitate away these inflammatory mediators. So I call it a molecular sponge.   There’s another set of mechanisms that we’re learning about that we’re able to use these amyloid proteins to do a couple of things to lymphocytes. One, it sets up a type 1 interferon response in lymphocytes. So the amyloid fibrils are a known trigger for the production of type 1 interferon, and type 1 interferon is actually beneficial for neuroinflammation; we have approved drugs. It’s doing another thing that we’re on the verge of publishing, but I’ll sort of give the headline without too many details; it’s setting up a type of lymphocyte that has a more regulatory function. So these are all rather unexpected roles for amyloid proteins.   MSDF And you have done adoptive transfer of some of these lymphocytes and find similar effects?   Dr. Steinman Yes. And the adoptive transfer experiments are very interesting. When we set up the system to produce a lot of type 1 interferon after we give an amyloid fibril, if the type of disease is what’s called the Th17 disease, the increased beta interferon actually worsens that, and if we create a disease that is called T-helper 1 – Th1 – then the type 1 interferon is beneficial. So we’ve engineered some amyloid structures so that they trigger less type 1 interferon, and when they trigger less type 1 interferon, then they work in both the Th1 and Th17 models. We published on that in the Journal of Experimental Medicine. But, again, even here with the type 1 interferon, the effect is nuanced and we can engineer these amyloid structures to be really beneficial and to take away the harm.   I wanted to say one thing, that clinicians and working scientists generally understand amyloid very well. Amyloid-beta that’s well known. Other amyloid proteins that people are, of course, familiar with are tau, prion protein, alpha-synuclein. But an amyloid structure is a general description of a protein that forms beta sheet, so the beta strand structure allows through hydrogen bonds the formation of what you should think of as a venetian blind, these monotonously parallel sheets that actually intercalate dyes, like Congo red or thioflavin T, so that when you shine polarized light on them they refract it in a polarized way. So we can make these structures, if you will, they’re organized nano particulars, to be more or less water-soluble, to be greater or lesser inducers of type 1 interferon. So there’s a whole armamentarium of very interesting amyloid structures that we can engineer to provide benefit in different situations.   Now what does this all mean for the Alzheimer’s hypothesis? And we’re doing an audio interview, so I’m sort of smiling wryly. I don’t want to get into that because we haven’t done the experiment in the amyloid-beta overproducing transgenic mice that have served as the model system to test whether various amyloid-lowering procedures will provide benefit, we just haven’t done that. And we’ve tried our particular approach in a number of other conditions ranging from stroke to EAE, as I said, to experimental heart attacks. And in the systems that we’ve studied, we see benefit.   MSDF But as a further proof of concept of what you have found in the protective effect of amyloid, you’ve looked at amyloid precursor protein knockout mice. Is that right?   Dr. Steinman Yes. Well, that’s a whole interesting story, and thanks for reminding me. So in a series of experiments that we have done and others have done, we first noticed that amyloid precursor protein knockout mice, they had worse EAE. Another person in Australia, Colin Masters, who’s actually one of the leaders in the field of Alzheimer’s research, looked at experimental head trauma, and in the amyloid precursor protein knockout mouse, they had a worse condition after head trauma that was alleviated by giving amyloid precursor protein in its soluble form. And then other people have shown that experimental encephalomyelitis is worse in prion knockout animals and in tau knockout animals.   We had been working with a protein called alpha-B crystallin, which is also an amyloid-forming protein, and we noticed that EAE was worse in the absence of alpha-B crystallin. So there’s a long series of experiments that loss of function, loss of the parent protein of these amyloid-producing molecules, leads to worsened inflammation, whether it’s EAE, head trauma, or somebody else did it in experimental heart attack. And we also did it in experimental stroke, so under a variety of conditions.   So this makes the argument even stronger, suggesting that amyloid structures when augmented can provide benefit and reduce inflammation, and when absent can actually exacerbate inflammation; so gain of function better, loss of function worse. So you have to look at the amyloid molecule as something that is not always harmful and pathologic. Whether it is the main culprit in Alzheimer’s, whether Alzheimer’s is an example of neuroinflammation, I leave it to people in that field because I really don’t want to take them on headlong at this point in time when we have all these fascinating results elsewhere. But I let the listeners draw their own conclusion based on the published work that I’m talking about, not only from my own lab but from other investigators all over the world.   One might want to think a little bit differently the next time one thinks about the deleterious effects of amyloid in Alzheimer’s, but I’m not going to be the one that takes on that massive scientific opinion, we’ll just have to see how it works out. I hope everyone’s been right over all these years because we certainly need some answers in that field. And if they are right, then we’ll have to integrate the kinds of things that we’re understanding about the role of amyloid proteins in other types of inflammatory conditions with a positive result in Alzheimer’s when it’s taken into the clinic. If it turns out that the experiments do not succeed in Alzheimer’s, then it will be easier to reconcile these different outcomes. But I think we’ll have to be patient; science doesn’t move as fast as some of us would like to have it move.   MSDF What was the time course of seeing a result by injecting the amyloid in your EAE models?   Dr. Steinman It’s very fast. When you inject the amyloid, it’s within 48 hours. If you stop giving the amyloid – we like to give it every day – if you stop giving it for a few days, the inflammation recurs, and that suggests that these amyloid structures are acting like a pharmaceutical. It’s not one of these situations that you sometimes see in science; you give the molecule once or twice and the disease goes away forever. This seems to be suppressing ongoing inflammation while it circulates, and when you take it away the effect is gone and the disease recurs, so that’s very interesting.   MSDF The effect seems to be too quick for remyelination to be occurring as the answer, but when you give it chronically do you see remyelination?   Dr. Steinman So far, we haven’t looked for long enough periods of time or with sensitive enough techniques. Your question triggers an experiment and we should really take a look at that. I would imagine that if you can abrogate inflammation that you’ll allow for remyelination if there’s anything left in the oligodendrocyte precursor to remyelinate itself, or if you need a little augmentation, it would be good to do a stem cell type of therapy under the protection of this kind of antiinflammatory approach.   MSDF Are you planning any early human trials?   Dr. Steinman Ha! I chuckle because this is a tough one to bring into the clinic. I’ve been funded by people who first scolded me for saying don’t take this too fast into the clinic, because I like to translate results. In this one, we’ll have to be more cautious than we might for other types of therapies.   MSDF Is there anything important to add?   Dr. Steinman I thought the questions were very comprehensive. And as you can see from where our matters stand now, there’s a lot of positive leads to pursue. And I think we’ll have to be cautious about translating in the fields of multiple sclerosis or stroke because of the infamy of the molecule I’m working with, but we’ll get there. Thank you.   MSDF Thank you.   [transition music]   Thank you for listening to Episode Forty-two of Multiple Sclerosis Discovery. This podcast was produced by the MS Discovery Forum, MSDF, the premier source of independent news and information on MS research. MSDF’s executive editor is Robert Finn. Msdiscovery.org is part of the non-profit Accelerated Cure Project for Multiple Sclerosis. Robert McBurney is our President and CEO, and Hollie Schmidt is vice president of scientific operations.   Msdiscovery.org aims to focus attention on what is known and not yet known about the causes of MS and related conditions, their pathological mechanisms, and potential ways to intervene. By communicating this information in a way that builds bridges among different disciplines, we hope to open new routes toward significant clinical advances.   We’re interested in your opinions. Please join the discussion on one of our online forums or send comments, criticisms, and suggestions to editor@msdiscovery.org.    [outro music]

Multiple sclerosis (MS) is an autoimmune inflammatory disease of the central nervous system (CNS). Myelin antigen(s) specific T cells, B cells, and antibodies are thought to play a role in the pathogenesis of MS. While the influence of autoantigenspecific CD4+ T cells has been extensively studied in animal models, the relevance of autoantigen specific B cells and their interactions with pathogenic T cells are largely unknown. The original aim of the present study was to create a new mouse model with which to investigate the interaction of myelin autoantigen specific B and T cells and their role in MS pathogenesis. The study was further expanded to analyze the nature and triggers of spontaneous disease and similarity of the mouse lesion pattern to that in human disease. The double-transgenic mouse (“Devic mouse”) strain presented here contains myelin oligodendrocyte glycoprotein (MOG)-specific T as well as B cells. A significant proportion (>50%) of these mice showed spontaneous experimentalautoimmune encephalomyelitis (EAE)-like disease at a young age. In contrast, all single transgenic littermates were free of clinical disease. Spontaneous EAE requires both MOG-specific T and B cells, since the breeding of MOG-specific Ig heavy chain knock-in mice with ovalbumin specific T cell receptor (TCR) transgenic mice did not develop any disease. Histological analysis of the CNS of affected mice revealed restricted localization of lesions in the spinal cord and optic nerves as well as severe demyelination and axonal damage that spared brain and cerebellum. The inflammatory infiltrates were predominantly composed of macrophages and CD4+ T cells, but occasionally also eosinophils. This peculiar localization of the demyelinating lesions and infiltration profile differ from classic EAE and is reminiscent of Devic’s neuromyelitis optica, a variant of classic MS in humans. It is not well understood what triggers the initiation of spontaneous EAE. The microbial environment does not significantly affect the clinical disease. Stimulation of the innate immune system with toll-like receptor (TLR) ligands or depletion of putative regulatory cells did not significantly affect EAE development. The (re-)activation of lymphocytes in sick Devic mice mainly occurs in the CNS without evidence of priming in the peripheral lymphoid organs. MOG-specific B and T cells cooperate by means of several mechanisms. MOGspecific B cells, which bind MOG but not the immunodominant peptide MOG 35-55 via their surface immunoglobulin (Ig), efficiently presented even high dilutions of MOG to T cells. This resulted in the enhanced proliferation of T and B cells as well as rapid activation. Stimulated T, but not B cells, secreted large amounts of Th1 cytokines IFNg and IL-2 along with small amounts of Th2 cytokine IL-5. In addition, MOG-stimulated T and B cells expressed a set of co-stimulatory molecules, which further help to modulate the proliferation and activation. Surprisingly, the doubletransgenic Devic mice, but not their single transgenic littermates, had high titers of MOG-specific IgG1 antibodies in the serum, which indicates a previous encounter with antigen in vivo. However, similar MOG-specific serum IgG1 titers were present irrespective of the clinical status. The transfer of EAE by Devic splenocytes in immunodeficient mice or by bone marrow reconstitution in wild-type mice further supported the in vivo cooperation of MOG-specific T and B cells to induce spontaneous EAE. In summary, Devic mice show several salient features that are important for study of the pathogenic mechanisms of CNS autoimmunity. As a model of spontaneous autoimmunity, they may allow us to study the triggering factors of autoimmunity as well as the factors that determine restricted infiltration of immune cells into the CNS.In addition, the model may be useful for validating novel therapies for autoimmune CNS diseases.