Podcasts about gerasimenko

En este episodio abordo la farmacología en neurorrehabilitación del adulto desde una perspectiva clínica y realista, pensada especialmente para profesionales no médicos que conviven a diario con informes, pautas y nombres de fármacos sin disponer siempre de un marco claro para interpretarlos. Recorremos los principales medicamentos utilizados en patologías neurológicas frecuentes —ictus, lesión medular, esclerosis múltiple, enfermedad de Parkinson, ELA, distonías y traumatismo craneoencefálico— diferenciando entre tratamientos agudos, terapias modificadoras de la enfermedad y manejo farmacológico de secuelas. A lo largo del episodio explico de forma progresiva los mecanismos de acción, la base neurofisiológica y el estado actual de la evidencia, poniendo especial énfasis en qué fármacos realmente cambian el pronóstico y cuáles cumplen un papel fundamentalmente sintomático. El objetivo no es prescribir, sino entender mejor cómo la farmacología condiciona la recuperación, la participación en terapia y la toma de decisiones en neurorrehabilitación, con una mirada crítica y basada en la evidencia disponible. Referencias del episodio: 1.     Adams, M. M., & Hicks, A. L. (2005). Spasticity after spinal cord injury. Spinal cord, 43(10), 577–586. https://doi.org/10.1038/sj.sc.3101757 (https://pubmed.ncbi.nlm.nih.gov/15838527/). 2.     AFFINITY Trial Collaboration (2020). Safety and efficacy of fluoxetine on functional outcome after acute stroke (AFFINITY): a randomised, double-blind, placebo-controlled trial. The Lancet. Neurology, 19(8), 651–660. https://doi.org/10.1016/S1474-4422(20)30207-6 (https://pubmed.ncbi.nlm.nih.gov/32702334/). 3.     Angeli, C. A., Edgerton, V. R., Gerasimenko, Y. P., & Harkema, S. J. (2014). Altering spinal cord excitability enables voluntary movements after chronic complete paralysis in humans. Brain : a journal of neurology, 137(Pt 5), 1394–1409. https://doi.org/10.1093/brain/awu038 (https://pubmed.ncbi.nlm.nih.gov/24713270/). 4.     Bracken, M. B., Shepard, M. J., Collins, W. F., Holford, T. R., Young, W., Baskin, D. S., Eisenberg, H. M., Flamm, E., Leo-Summers, L., & Maroon, J. (1990). A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal-cord injury. Results of the Second National Acute Spinal Cord Injury Study. The New England journal of medicine, 322(20), 1405–1411. https://doi.org/10.1056/NEJM199005173222001 (https://pubmed.ncbi.nlm.nih.gov/2278545/). 5.     Bracken, M. B., Shepard, M. J., Holford, T. R., Leo-Summers, L., Aldrich, E. F., Fazl, M., Fehlings, M., Herr, D. L., Hitchon, P. W., Marshall, L. F., Nockels, R. P., Pascale, V., Perot, P. L., Jr, Piepmeier, J., Sonntag, V. K., Wagner, F., Wilberger, J. E., Winn, H. R., & Young, W. (1997). Administration of methylprednisolone for 24 or 48 hours or tirilazad mesylate for 48 hours in the treatment of acute spinal cord injury. Results of the Third National Acute Spinal Cord Injury Randomized Controlled Trial. National Acute Spinal Cord Injury Study. JAMA, 277(20), 1597–1604 (https://pubmed.ncbi.nlm.nih.gov/9168289/). 6.     Cardenas, D. D., Ditunno, J. F., Graziani, V., McLain, A. B., Lammertse, D. P., Potter, P. J., Alexander, M. S., Cohen, R., & Blight, A. R. (2014). Two phase 3, multicenter, randomized, placebo-controlled clinical trials of fampridine-SR for treatment of spasticity in chronic spinal cord injury. Spinal cord, 52(1), 70–76. https://doi.org/10.1038/sc.2013.137 (https://pubmed.ncbi.nlm.nih.gov/24216616/). 7.     Chollet, F., Tardy, J., Albucher, J. F., Thalamas, C., Berard, E., Lamy, C., Bejot, Y., Deltour, S., Jaillard, A., Niclot, P., Guillon, B., Moulin, T., Marque, P., Pariente, J., Arnaud, C., & Loubinoux, I. (2011). Fluoxetine for motor recovery after acute ischaemic stroke (FLAME): a randomised placebo-controlled trial. The Lancet. Neurology, 10(2), 123–130. https://doi.org/10.1016/S1474-4422(10)70314-8 (https://pubmed.ncbi.nlm.nih.gov/21216670/). 8.     Dávalos, A., Alvarez-Sabín, J., Castillo, J., Díez-Tejedor, E., Ferro, J., Martínez-Vila, E., Serena, J., Segura, T., Cruz, V. T., Masjuan, J., Cobo, E., Secades, J. J., & International Citicoline Trial on acUte Stroke (ICTUS) trial investigators (2012). Citicoline in the treatment of acute ischaemic stroke: an international, randomised, multicentre, placebo-controlled study (ICTUS trial). Lancet (London, England), 380(9839), 349–357. https://doi.org/10.1016/S0140-6736(12)60813-7 (https://pubmed.ncbi.nlm.nih.gov/22691567/). 9.     EFFECTS Trial Collaboration (2020). Safety and efficacy of fluoxetine on functional recovery after acute stroke (EFFECTS): a randomised, double-blind, placebo-controlled trial. The Lancet. Neurology, 19(8), 661–669. https://doi.org/10.1016/S1474-4422(20)30219-2 (https://pubmed.ncbi.nlm.nih.gov/32702335/). 10.  Fehlings, M. G., Theodore, N., Harrop, J., Maurais, G., Kuntz, C., Shaffrey, C. I., Kwon, B. K., Chapman, J., Yee, A., Tighe, A., & McKerracher, L. (2011). A phase I/IIa clinical trial of a recombinant Rho protein antagonist in acute spinal cord injury. Journal of neurotrauma, 28(5), 787–796. https://doi.org/10.1089/neu.2011.1765 (https://pubmed.ncbi.nlm.nih.gov/21381984/). 11.  FOCUS Trial Collaboration (2019). Effects of fluoxetine on functional outcomes after acute stroke (FOCUS): a pragmatic, double-blind, randomised, controlled trial. Lancet (London, England), 393(10168), 265–274. https://doi.org/10.1016/S0140-6736(18)32823-X (https://pubmed.ncbi.nlm.nih.gov/30528472/). 12.  Forgione, N., & Fehlings, M. G. (2014). Rho-ROCK inhibition in the treatment of spinal cord injury. World neurosurgery, 82(3-4), e535–e539. https://doi.org/10.1016/j.wneu.2013.01.009 (http://pubmed.ncbi.nlm.nih.gov/23298675/). 13.  Fournier, A. E., Takizawa, B. T., & Strittmatter, S. M. (2003). Rho kinase inhibition enhances axonal regeneration in the injured CNS. The Journal of neuroscience : the official journal of the Society for Neuroscience, 23(4), 1416–1423. https://doi.org/10.1523/JNEUROSCI.23-04-01416.2003 (https://pubmed.ncbi.nlm.nih.gov/12598630/). 14.  Giacino, J. T., Whyte, J., Bagiella, E., Kalmar, K., Childs, N., Khademi, A., Eifert, B., Long, D., Katz, D. I., Cho, S., Yablon, S. A., Luther, M., Hammond, F. M., Nordenbo, A., Novak, P., Mercer, W., Maurer-Karattup, P., & Sherer, M. (2012). Placebo-controlled trial of amantadine for severe traumatic brain injury. The New England journal of medicine, 366(9), 819–826. https://doi.org/10.1056/NEJMoa1102609 (https://pubmed.ncbi.nlm.nih.gov/22375973/). 15.  Goodman, A. D., Brown, T. R., Krupp, L. B., Schapiro, R. T., Schwid, S. R., Cohen, R., Marinucci, L. N., Blight, A. R., & Fampridine MS-F203 Investigators (2009). Sustained-release oral fampridine in multiple sclerosis: a randomised, double-blind, controlled trial. Lancet (London, England), 373(9665), 732–738. https://doi.org/10.1016/S0140-6736(09)60442-6 (https://pubmed.ncbi.nlm.nih.gov/19249634/). 16.  Goodman, A. D., Brown, T. R., Edwards, K. R., Krupp, L. B., Schapiro, R. T., Cohen, R., Marinucci, L. N., Blight, A. R., & MSF204 Investigators (2010). A phase 3 trial of extended release oral dalfampridine in multiple sclerosis. Annals of neurology, 68(4), 494–502. https://doi.org/10.1002/ana.22240 (https://pubmed.ncbi.nlm.nih.gov/20976768/). 17.  Hurlbert, R. J., Hadley, M. N., Walters, B. C., Aarabi, B., Dhall, S. S., Gelb, D. E., Rozzelle, C. J., Ryken, T. C., & Theodore, N. (2013). Pharmacological therapy for acute spinal cord injury. Neurosurgery, 72 Suppl 2, 93–105. https://doi.org/10.1227/NEU.0b013e31827765c6 (https://pubmed.ncbi.nlm.nih.gov/23417182/). 18.  Johnston, S. C., Amarenco, P., Denison, H., Evans, S. R., Himmelmann, A., James, S., Knutsson, M., Ladenvall, P., Molina, C. A., Wang, Y., & THALES Investigators (2020). Ticagrelor and Aspirin or Aspirin Alone in Acute Ischemic Stroke or TIA. The New England journal of medicine, 383(3), 207–217. https://doi.org/10.1056/NEJMoa1916870 (https://pubmed.ncbi.nlm.nih.gov/32668111/). 19.  Kheder, A., & Nair, K. P. (2012). Spasticity: pathophysiology, evaluation and management. Practical neurology, 12(5), 289–298. https://doi.org/10.1136/practneurol-2011-000155 (https://pubmed.ncbi.nlm.nih.gov/22976059/). 20.  Kirkman, M. A., Day, J., Gehring, K., Zienius, K., Grosshans, D., Taphoorn, M., Li, J., & Brown, P. D. (2022). Interventions for preventing and ameliorating cognitive deficits in adults treated with cranial irradiation. The Cochrane database of systematic reviews, 11(11), CD011335. https://doi.org/10.1002/14651858.CD011335.pub3 (https://pubmed.ncbi.nlm.nih.gov/36427235/). 21.  Martinsson L, Hårdemark H, Eksborg S. Amphetamines for improving recovery after stroke. Cochrane Database Syst Rev. 2007 Jan 24;2007(1):CD002090. doi: 10.1002/14651858.CD002090.pub2. PMID: 17253474; PMCID: PMC12278358 (https://pubmed.ncbi.nlm.nih.gov/17253474/). 22.  Miller, T. M., Cudkowicz, M. E., Genge, A., Shaw, P. J., Sobue, G., Bucelli, R. C., Chiò, A., Van Damme, P., Ludolph, A. C., Glass, J. D., Andrews, J. A., Babu, S., Benatar, M., McDermott, C. J., Cochrane, T., Chary, S., Chew, S., Zhu, H., Wu, F., Nestorov, I., … VALOR and OLE Working Group (2022). Trial of Antisense Oligonucleotide Tofersen for SOD1 ALS. The New England journal of medicine, 387(12), 1099–1110. https://doi.org/10.1056/NEJMoa2204705 (https://pubmed.ncbi.nlm.nih.gov/36129998/). 23.  Mueller, B. K., Mack, H., & Teusch, N. (2005). Rho kinase, a promising drug target for neurological disorders. Nature reviews. Drug discovery, 4(5), 387–398. https://doi.org/10.1038/nrd1719 (https://pubmed.ncbi.nlm.nih.gov/15864268/). 24.  Nourbakhsh, B., Revirajan, N., & Waubant, E. (2018). Treatment of fatigue with methylphenidate, modafinil and amantadine in multiple sclerosis (TRIUMPHANT-MS): Study design for a pragmatic, randomized, double-blind, crossover clinical trial. Contemporary clinical trials, 64, 67–76. https://doi.org/10.1016/j.cct.2017.11.005 (https://pubmed.ncbi.nlm.nih.gov/29113955/). 25.  Paganoni, S., Hendrix, S., Dickson, S. P., Knowlton, N., Macklin, E. A., Berry, J. D., Elliott, M. A., Maiser, S., Karam, C., Caress, J. B., Owegi, M. A., Quick, A., Wymer, J., Goutman, S. A., Heitzman, D., Heiman-Patterson, T. D., Jackson, C. E., Quinn, C., Rothstein, J. D., Kasarskis, E. J., … Cudkowicz, M. E. (2021). Long-term survival of participants in the CENTAUR trial of sodium phenylbutyrate-taurursodiol in amyotrophic lateral sclerosis. Muscle & nerve, 63(1), 31–39. https://doi.org/10.1002/mus.27091 (https://pubmed.ncbi.nlm.nih.gov/33063909/). 26.  Schwab M. E. (2004). Nogo and axon regeneration. Current opinion in neurobiology, 14(1), 118–124. https://doi.org/10.1016/j.conb.2004.01.004 (https://pubmed.ncbi.nlm.nih.gov/15018947/). 27.  Shneider, N. A., Harms, M. B., Korobeynikov, V. A., Rifai, O. M., Hoover, B. N., Harrington, E. A., Aziz-Zaman, S., Singleton, J., Jamil, A., Madan, V. R., Lee, I., Andrews, J. A., Smiley, R. M., Alam, M. M., Black, L. E., Shin, M., Watts, J. K., Walk, D., Newman, D., Pascuzzi, R. M., … Bennett, C. F. (2025). Antisense oligonucleotide jacifusen for FUS-ALS: an investigator-initiated, multicentre, open-label case series. Lancet (London, England), 405(10494), 2075–2086. https://doi.org/10.1016/S0140-6736(25)00513-6 (https://pubmed.ncbi.nlm.nih.gov/40414239/). 28.  Stocchi, F., Bravi, D., Emmi, A., & Antonini, A. (2024). Parkinson disease therapy: current strategies and future research priorities. Nature reviews. Neurology, 20(12), 695–707. https://doi.org/10.1038/s41582-024-01034-x (https://pubmed.ncbi.nlm.nih.gov/39496848/).

Im Jahr 1969 entdeckt Swetlana Gerasimenko gemeinsam mit ihrem Kollegen Klim Tschurjumow einen Kometen. Dieser wird mehr als 40 Jahre später zufällig Ziel der ESA-Kometenmission Rosetta – und beschert der ukrainischen Astronomin weltweiten Ruhm. Lorenzen, Dirk www.deutschlandfunk.de, Sternzeit

CTO Series: Sergey's Leadership Insights—Bridging Innovation and Strategy as CTO of CrateDB   In this BONUS episode, we sit down with Sergey, the forward-thinking CTO of CrateDB, to unpack his journey from Nokia to CrateDB and his leadership philosophy that blends technical expertise with strategic foresight. We dive into the key moments that shaped his career, the challenges of scaling technology in a competitive market, and how Sergey aligns his team's efforts with broader business goals while staying adaptable in an ever-evolving tech landscape.   The Defining Moment in Sergey's Leadership Journey   “Being a cheerleader, servant, and strategist for your team creates an environment where innovation can thrive.”   Sergey shares how working at Nokia with an inspiring people manager, Sotiris, influenced his leadership approach. Sotiris embodied servant leadership and made strategic thinking a team-wide responsibility. Sergey reflects on how this mindset helped him approach his current role at CrateDB, emphasizing the importance of not only building great products but ensuring they resonate in the market through thoughtful sales and marketing alignment. “The best leaders help their teams see what's next—not just solve today's problems.” Navigating Product-Market Fit for Technical Products “For technical products, adoption is not just about features—it's about connecting with both developers and decision-makers.”   Sergey breaks down the challenges of achieving product-market fit for developer-centric solutions like CrateDB. He explains the dual approach of engaging both top-down decision-makers, like CTOs, and bottom-up developer communities. By drawing from his startup experience, Sergey underscores the importance of building trust and delivering a developer experience that wins over early adopters.   “The real challenge is bridging the gap between leadership adoption and the developers who use the product every day.”   The Impact of AI on Developer Experience “AI's true transformation lies in how it enhances the products we already use, often invisibly.”   When asked about AI's current role, Sergey reflects on the potential of AI-powered tools to transform workflows over the next few years. While not yet life-changing for his daily routine, he anticipates that AI's influence will soon be felt through the optimization of background processes in everyday tools and databases.   “The future isn't about flashy AI features—it's about smarter tools that simplify complex workflows.”   Aligning Tech Strategy with Business Goals “A strong strategy needs to be a story that teams can rally around and imagine themselves in.”   Sergey details CrateDB's unique approach to strategic planning, inspired by open-source RFCs (Request for Comments). Instead of rigid OKRs, they craft stories that clarify priorities and invite feedback from across the organization. He highlights the importance of quarterly check-ins and building checkpoints to validate assumptions along the way.   Key tips in this segment: Document the assumptions behind the strategy. Break initiatives into steps to test their feasibility. Avoid deadline-driven development; focus on value-driven milestones.   Fostering Collaboration Between Tech and Business Units “Collaboration thrives when both sides understand the trade-offs involved in strategic decisions.”   Sergey explains how collaboration between engineering and business leaders is fostered through transparency and communication. Product managers and engineering leads play key roles in advocating for priorities and ensuring alignment across teams. Sergey emphasizes the value of making trade-offs explicit to avoid silos.   “The best partnerships between tech and business come from mutual understanding—not just of goals, but of constraints.”   Staying Ahead with Strategic Roadmapping   “A good strategy diagnoses the situation, sets guiding policies, and outlines coherent actions.”   Sergey highlights the importance of competitive intelligence in staying ahead of market trends without reacting impulsively. In the world of databases, long adoption cycles offer the advantage of thoughtful strategic planning. He references the book Good Strategy/Bad Strategy and describes how CrateDB maintains an evergreen list of initiatives that can be prioritized when needed.   “Don't just chase trends—create a strategy that withstands change by focusing on long-term coherence.”   Overcoming the Challenges of the CTO Role   “The CTO role is often ambiguous—define it based on your organization's needs.”   Sergey candidly discusses the challenge of imposter syndrome and the ambiguity that comes with the CTO title. He outlines two common archetypes: the technical expert versus the team builder and cultural leader. He stresses the importance of adjusting the role to the organization's maturity and goals.   “Your leadership role isn't static—adapt your approach to meet your organization where it is.”   Books That Shaped Sergey's Leadership Approach   “Most tech problems are people problems disguised as engineering issues.”   Sergey shares the books that influenced his leadership style: Peopleware by Tom DeMarco: Reinforces the idea that technical challenges often stem from team dynamics. Drive by Daniel Pink: Highlights the importance of autonomy, mastery, and purpose in motivating teams. Good to Great by Jim Collins: Explores what makes some companies thrive while others stagnate. About Sergey Gerasimenko Sergey is the innovative CTO of CrateDB, leading the charge in real-time analytics and hybrid search. Previously, he was VP of Engineering at MongoDB, shaping the edge device strategy, and at Realm, a leading open-source mobile/embedded database acquired by MongoDB in 2019. With a career spanning groundbreaking roles at Brainly and Nokia, Sergey co-founded two companies and holds a patent. His leadership continues to push the boundaries of tech innovation. You can link with Sergey Gerasimenko on LinkedIn.

En el episodio de hoy, tratamos de responder a la pregunta que formulamos, sobre todo matizando la autonomía o no de esos CPGs en la médula humana. Revisamos los principales autores y estudios sobre el tema y ahondamos en la evidencia más actual sobre el sistema de interneuronas que conforman los CPGs y las implicaciones para la neurorrehabilitación (estimulación epidural y terapia intensiva). Referencias del episodio: 1. Angeli, C. A., Edgerton, V. R., Gerasimenko, Y. P., & Harkema, S. J. (2014). Altering spinal cord excitability enables voluntary movements after chronic complete paralysis in humans. Brain : a journal of neurology, 137(Pt 5), 1394–1409. https://doi.org/10.1093/brain/awu038 (https://pubmed.ncbi.nlm.nih.gov/24713270/). 2. Barkan, C. L., & Zornik, E. (2019). Feedback to the future: motor neuron contributions to central pattern generator function. The Journal of experimental biology, 222(Pt 16), jeb193318. https://doi.org/10.1242/jeb.193318 (https://pmc.ncbi.nlm.nih.gov/articles/PMC6739810/). 3. Brown, T. G. (1911). The Intrinsic Factors in the Act of Progression in the Mammal. Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character, 84(572), 308–319. http://www.jstor.org/stable/80647 (https://www.jstor.org/stable/80647). 4. Cherni, Y., Begon, M., Chababe, H., & Moissenet, F. (2017). Use of electromyography to optimize Lokomat® settings for subject-specific gait rehabilitation in post-stroke hemiparetic patients: A proof-of-concept study. Neurophysiologie clinique = Clinical neurophysiology, 47(4), 293–299. https://doi.org/10.1016/j.neucli.2017.01.008 (https://pubmed.ncbi.nlm.nih.gov/28318816/). 5. Courtine, G., Gerasimenko, Y., van den Brand, R., Yew, A., Musienko, P., Zhong, H., Song, B., Ao, Y., Ichiyama, R. M., Lavrov, I., Roy, R. R., Sofroniew, M. V., & Edgerton, V. R. (2009). Transformation of nonfunctional spinal circuits into functional states after the loss of brain input. Nature neuroscience, 12(10), 1333–1342. https://doi.org/10.1038/nn.2401 (https://pubmed.ncbi.nlm.nih.gov/19767747/). 6. Dietz V. (2010). Behavior of spinal neurons deprived of supraspinal input. Nature reviews. Neurology, 6(3), 167–174. https://doi.org/10.1038/nrneurol.2009.227 (https://pubmed.ncbi.nlm.nih.gov/20101254/). 7. Dimitrijevic, M. R., Gerasimenko, Y., & Pinter, M. M. (1998). Evidence for a spinal central pattern generator in humans. Annals of the New York Academy of Sciences, 860, 360–376. https://doi.org/10.1111/j.1749-6632.1998.tb09062.x (https://pubmed.ncbi.nlm.nih.gov/9928325/). 8. Dzeladini, F., van den Kieboom, J., & Ijspeert, A. (2014). The contribution of a central pattern generator in a reflex-based neuromuscular model. Frontiers in human neuroscience, 8, 371. https://doi.org/10.3389/fnhum.2014.00371 (https://pmc.ncbi.nlm.nih.gov/articles/PMC4071613/). 9. Gizzi, L., Nielsen, J. F., Felici, F., Moreno, J. C., Pons, J. L., & Farina, D. (2012). Motor modules in robot-aided walking. Journal of neuroengineering and rehabilitation, 9, 76. https://doi.org/10.1186/1743-0003-9-76 (https://pubmed.ncbi.nlm.nih.gov/23043818/). 10. Gosgnach S. (2022). Synaptic connectivity amongst components of the locomotor central pattern generator. Frontiers in neural circuits, 16, 1076766. https://doi.org/10.3389/fncir.2022.1076766 (https://pmc.ncbi.nlm.nih.gov/articles/PMC9730330/). 11. Grillner, S. (1981). Control of Locomotion in Bipeds, Tetrapods, and Fish. Comprehensive Physiology, 1179-1236 (https://onlinelibrary.wiley.com/doi/10.1002/cphy.cp010226). 12. Guertin P. A. (2014). Preclinical evidence supporting the clinical development of central pattern generator-modulating therapies for chronic spinal cord-injured patients. Frontiers in human neuroscience, 8, 272. https://doi.org/10.3389/fnhum.2014.00272 (https://pubmed.ncbi.nlm.nih.gov/24910602/). 13. Harkema, S., Gerasimenko, Y., Hodes, J., Burdick, J., Angeli, C., Chen, Y., Ferreira, C., Willhite, A., Rejc, E., Grossman, R. G., & Edgerton, V. R. (2011). Effect of epidural stimulation of the lumbosacral spinal cord on voluntary movement, standing, and assisted stepping after motor complete paraplegia: a case study. Lancet (London, England), 377(9781), 1938–1947. https://doi.org/10.1016/S0140-6736(11)60547-3 (https://pubmed.ncbi.nlm.nih.gov/21601270/). 14. Kathe, C., Skinnider, M. A., Hutson, T. H., Regazzi, N., Gautier, M., Demesmaeker, R., Komi, S., Ceto, S., James, N. D., Cho, N., Baud, L., Galan, K., Matson, K. J. E., Rowald, A., Kim, K., Wang, R., Minassian, K., Prior, J. O., Asboth, L., Barraud, Q., … Courtine, G. (2022). The neurons that restore walking after paralysis. Nature, 611(7936), 540–547. https://doi.org/10.1038/s41586-022-05385-7 (https://pubmed.ncbi.nlm.nih.gov/36352232/). 15. Minassian, K., Jilge, B., Rattay, F., Pinter, M. M., Binder, H., Gerstenbrand, F., & Dimitrijevic, M. R. (2004). Stepping-like movements in humans with complete spinal cord injury induced by epidural stimulation of the lumbar cord: electromyographic study of compound muscle action potentials. Spinal cord, 42(7), 401–416. https://doi.org/10.1038/sj.sc.3101615 (https://pubmed.ncbi.nlm.nih.gov/15124000/). 16. Minassian, K., Persy, I., Rattay, F., Dimitrijevic, M. R., Hofer, C., & Kern, H. (2007). Posterior root-muscle reflexes elicited by transcutaneous stimulation of the human lumbosacral cord. Muscle & nerve, 35(3), 327–336. https://doi.org/10.1002/mus.20700 (https://pubmed.ncbi.nlm.nih.gov/17117411/). 17. Radhakrishna, M., Steuer, I., Prince, F., Roberts, M., Mongeon, D., Kia, M., Dyck, S., Matte, G., Vaillancourt, M., & Guertin, P. A. (2017). Double-Blind, Placebo-Controlled, Randomized Phase I/IIa Study (Safety and Efficacy) with Buspirone/Levodopa/Carbidopa (SpinalonTM) in Subjects with Complete AIS A or Motor-Complete AIS B Spinal Cord Injury. Current pharmaceutical design, 23(12), 1789–1804. https://doi.org/10.2174/1381612822666161227152200 (https://pubmed.ncbi.nlm.nih.gov/28025945/). 18. Reier, P. J., Howland, D. R., Mitchell, G., Wolpaw, J. R., Hoh, D., & Lane, M. A. (2017). Spinal cord injury: repair, plasticity and rehabilitation. eLS, 1-12 (https://onlinelibrary.wiley.com/doi/abs/10.1002/9780470015902.a0021403.pub2).

Episode 97:This week we're continuing Russia in Revolution An Empire in Crisis 1890 - 1928 by S. A. Smith[Part 1]Introduction[Part 2-5]1. Roots of Revolution, 1880s–1905[Part 6-8]2. From Reform to War, 1906-1917[Part 9 - This Week]3. From February to October 1917 - 0:30Dual Power - 8:48[Part 9 - 11?]3. From February to October 1917[Part 12 - 15?]4. Civil War and Bolshevik Power[Part 16 - 18?]5. War Communism[Part 19 - 21?]6. The New Economic Policy: Politics and the Economy[Part 22 - 25?]7. The New Economic Policy: Society and Culture[Part 26?]ConclusionFigure 3.1 - 6:12[see the image here]Caption: Soldiers' wives demonstrate for an increased ration. Their banners read: ‘An increased ration to the families of soldiers, the defenders of freedom and of a people's peace'; and ‘Feed the children of the defenders of the motherland'.Footnotes:1) 0:50Tsuyoshi Hasegawa, The February Revolution: Petrograd 1917 (Seattle: University of Washington Press, 1981).2) 3:06Cited Figes, People's Tragedy, 323.3) 4:27A. B. Nikolaev, Revoliutsiia i vlast': IV Gosudarstvennaia duma 27 fevralia–3 marta 1917 goda (St Petersburg: Izd-vo RGPU, 2005).4) 6:05Pethybridge, Witnesses, 76, 78, 119–20.5) 6:41Orlando Figes and Boris Kolonitskii, Interpreting the Russian Revolution: The Language and Symbols of 1917 (New Haven, CT: Yale University Press, 1999), ch. 1; Pavel G. Rogoznyi, ‘The Russian Orthodox Church during the First World War and Revolutionary Turmoil, 1914–1921', in Murray Frame et al. (eds), Russian Culture in War and Revolution, 1914–22, 1 (Bloomington, IN: Slavica, 2014), 349–76.6) 7:16Nadezhda Krupskaya, Reminiscences of Lenin, .7) 7:41I. L. Arkhipov, ‘Obshchestvennaia psikhologiia petrogradskikh obyvatelei v 1917 godu', Voprosy istorii, 7 (1994), 49–58 (52).8) 9:05Rex Wade, The Russian Revolution, 1917 (Cambridge: Cambridge University Press, 2000), ch. 3.9) 9:48V. I. Startsev, Vnutrenniaia politika vremennogo pravitel'stva pervogo sostava (Leningrad: Nauka, 1980), 116.10) 11:21William G. Rosenberg, Liberals in the Russian Revolution: The Constitutional Democratic Party, 1917–1921 (Princeton, NJ: Princeton University Press, 1974).11) 11:50Starstev, Vnutrenniaia politika, 208–45. I am indebted to Ian Thatcher for this point.12) 13:19Ziva Galili y Garcia, The Menshevik Leaders in the Russian Revolution: Social Realities and Political Strategies (Princeton, NJ: Princeton University Press, 1989).13) 14:47William G. Rosenberg, ‘Social Mediation and State Construction(s) in Revolutionary Russia', Social History, 19:2 (1994), 168–88.14) 15:37For the Soviet proclamation see Alfred Golder (ed.), Documents of Russian History, 1914–1917 (New York: The Century Co., 1927), 325–6.15) 16:31Rex A. Wade, The Russian Search for Peace: February to October 1917 (Stanford, CA: Stanford University Press, 1969).16) 16:37Starstev, Vnutrenniaia politika, 204.17) 17:18G. A. Gerasimenko, Pervy akt narodovlastiia v Rossii: obshchestvennye ispolnitel'nye komitety 1917g. (Moscow: Nika, 1992), 82.18) 17:34Gerasimenko, Pervy akt, 106.19) 18:31William G. Rosenberg, ‘The Russian Municipal Duma Elections of 1917', Soviet Studies, 21:2 (1969), 131–63, 157.20) 19:07Nikolai N. Smirnov, ‘The Soviets', in Edward Acton et al. (eds), Critical Companion to the Russian Revolution, 1914–1921 (London: Arnold, 1997), 429–37 (432).21) 20:50Smirnov, ‘Soviets', 434.22) 21:16V. I. Lenin, State and Revolution, .23) 22:14A. F. Zhukov, Ideino-politicheskii krakh eserovskogo maksimalizma (Leningrad: Izd-vo Leningradskogo universiteta, 1979), 49.24) 23:05Leopold H. Haimson et al. (eds), Men'sheviki v 1917 godu (3 vols), vol. 2 (Moscow: Progress-Akademiia, 1995), 48–9.25) 24:25Michael Melancon, ‘The Socialist Revolutionary Party, 1917–1920', in Acton et al. (eds), Critical Companion to the Russian Revolution, 281–90; Kh. M. Astrakhan, Bol'sheviki i ikh politicheskie protivniki v 1917g. (Leningrad: Leninizdat, 1973), 233.

Scaletta:

When a trend takes off in the affiliate marketing industry, everyone one flocks to the masses. Zeropark has been able to cut against the grain and differentiate themselves from the crowd for years. Push traffic is no exception to the hype and Zeropark has been able to stay at the forefront. As one of the fastest-growing businesses, we had to dive deeper into the mad minds behind the growth of this Company. We got a few minutes to speak with Alexander Gerasimenko and figure out how the team at Codewise keeps the bankroll flowing in for affiliates. You may find it interesting that Alex started from the entry ranks as an Account Manager and hustled his way up to the top in is current COO position with Zeropark. Now he is in charge of structuring a dynamic platform for all parties that are involved in making this company a success. If you have an ounce of doubt on whether you can trust Zeropark, this podcast should change your perspective. The idea that one of the largest push notification databases is run by such a tight-knit team will amaze you. Alex will also drop some major golden nuggets on: some geos that you would not have expected to be top converting and his tips for how to get an affiliate manager with zeropark even if you aren't dishing out $2k a month in ad spend. best performing verticals for affiliates right now Zeropark stands tall in a consistently changing environment where regulations and citations can whiplash a company into arrears. Fortunately, Zeropark adopted a business model that not only guarantees quality from their traffic sources but builds trust with their clients. Focusing on quality over quantity has been one of the core drivers of their longterm profitability and success with this new traffic source. Coming into push traffic from pop and domain redirect was not an easy transition even though it was smooth internal client adaptation. Keeping the quality as the main focus has proven itself to be one major recurring benefit to affiliates who run traffic with Zeropark besides their easy interface and extensive volume that they can deliver. What will motivate you to get started with push traffic? Do possess any of the qualities that Alex says the 'ideal affiliate' would have? Tune in to this episode of Affiliate Hustle and find out everything you need to know about how to make serious profits with push notifications on Zeropark.

L'intervista al giornalista de La Stampa Domenico Latagliata sulla vicenda dell'Auxilium, esclusa dalla Lega Basket in seguito alla cessione della società all'imprenditore russo Gerasimenko.

Nella nuova puntata, con noi Piero Guerrini di Tuttosport per analizzare la situazione della Fiat Torino.Questi i temi trattati:- L'inizio con Larry Brown, cosa non ha funzionato- La gestione Forni- I problemi evidenti ma non corretti per tempo- Il rischio della sparizione- L'intervento di Gerasimenko e una nuova vita- Pillole di NBA attuale

A BDP un graditissimo ritorno con Werther Pedrazzi, penna del Corriere della sera, profondo conoscitore di pallacanestro e appassionato di lunga data. Con lui abbiamo toccato diversi temi :- Nunnally e il 20-0 di Pistoia Milano- La Cantù allo sbando di Gerasimenko: i motivi- Il caso Mike Hall tra razzismo e società

We take a look at one of the major symptoms of the impending death of newspapers, and the celebrate the fact that we (humans) hit a comet with a robot.   Show Notes: Old People now rule the funnies! http://www.timesdispatch.com/entertainment-life/judge-parker-rex-morgan-mark-trail-win-reader-vote-on/article_cb536c63-a05f-5b66-85e7-a2fe8b3d2fcb.html   Rosetta: Ambition: The Film: http://www.youtube.com/watch?v=H08tGjXNHO4