Podcasts about Albin

This week Andre Arian and Albin talk about the week of football that we just saw and the final regular season weekend.Örebro showed that Carlstad can indeed be beaten, Tyresö made quick work of Limhamn, Gothernburg and Kristianstad had a interesting game and Stockholm crushed AIK in a way we havent seen in a while!We also talk about the games that are being played this week and the playoff implications the games have and each senario that can happen!

"I think it's very important to stand for something. If I die today or tomorrow, will I be missed? And if the answer is no, what am I doing here? I need to change what I'm doing. I want to be liked. And that's the same for us as a brand."Episode summaryOur Pulse Special series features the hottest content from the UK's leading ecommerce event, including panel discussions with respected brands and technology vendors.Exclusive to Inside Commerce, these discussions share interesting insights from respected industry practitioners.In this episode, Axel Arigato's CEO & co-founder, Albin Johansson, shares the ambitious steps he took to transform a small Swedish label into a worldwide phenomenon, from launching the “drop of the week” strategy to opening stores in London, New York and Dubai.Most brands chase fleeting attention; Axel Arigato's story proves that a sustained focus on authenticity, community and physical presence can turn a niche brand into a global icon.Discover how they built their brand on the principles of genuine connection and staying true to their roots, despite scaling in a noisy, distracted digital world.We break down the importance of “top of mind” thinking, the power of physical spaces in a digital era, and why authenticity beats superficial trends every time. You'll learn how Axel Arigato navigated turning a risky brick-and-mortar expansion into a success, and why their deliberate, community-focused approach keeps them relevant, even after more than a decade of growth.If you're wondering how to stand out without sacrificing your core values, this episode will inspire you to get back to basics. Albin's journey is proof that genuine, purposeful brand building can cut through the noise and create a lasting global footprint.Podcast HighlightsBuilding with Intent: Albin discusses the importance of authenticity and being genuine in brand building, emphasizing the need to own something unique in the market.From Digital to Physical: The transition from a 100% digital brand to opening physical stores, highlighting the importance of meeting customers in person and presenting the brand's universe.Lessons Learned: Albin reflects on the mistakes made during rapid scaling, emphasizing the need to return to the brand's core values and not accept mediocrity.Community and Authenticity: The focus on building and inspiring a community, and the challenges of maintaining authenticity in a crowded market.

Har den förre landslagsmittfältaren Albin Ekdal en gudfar med väldigt bra pigment? Klickar hans pappa inte med ”Granens” pappa? Och stod han på samma studentflak som en kille som senare skulle komma att dömas för ekobrott? Hosted on Acast. See acast.com/privacy for more information.

Zum dritten Mal in 16 Monaten hat der Kosovo ein neues Parlament gewählt. Gewonnen hat die Partei Vetevendosje von Regierungschef Albin Kurtin. Die freie Journalistin Adelina Gashi erklärt, warum Kurtin nach wie vor viel Unterstützung im Kosovo geniesst. · Russland rationiert Treibstoffe, vor allem auf der annektierten Halbinsel Krim und im besetzten ukrainischen Gebiet Luhansk. Und auch in Moskau sprechen Tankstellenbetreiber von Versorgungsengpässen. Wie knapp ist der Treibstoff in Russland und in den besetzten Gebieten momentan? Und wie erklären die Behörden die Engpässe? Die Einschätzung von Osteuropa-Korrespondent Calum MacKenzie. · Der starke Schweizer Franken drückt der Schweizer Exportwirtschaft auf die Stimmung. Ihre Produkte werden im Ausland teurer – und das müssen die Schweizer Firmen teilweise bei ihrer Marge kompensieren. Am Swiss Economic Forum SEF haben wir unter anderem mit Claudia Moerker gesprochen. Sie ist Geschäftsleiterin des Verbands Swiss Export. Wir haben sie gefragt, wie gut die Unternehmen den starken Franken momentan wegstecken können. · Dass der Schweizer Franken so stark ist, hat auch historische Gründe. Zum Beispiel eine relativ niedrige Inflationsrate. Der Ökonom Adriel Jost erklärt, warum die Schweiz eine so stabile Währung hat – und wer davon profitiert.

This week Andre, Albin and Arian talk about the games that were and the games that are coming!Stockholm went down south to Malmö and came home with victory against a tough running Limhamn, Kristianstad traveled north to Bergshamra in the Toilet Bowl where AIK showed that they may have found their QB for the final stretch of the season and Örebro welcomed a high powered Tyresö passing attack to Behrn Arena, but its what happened long after the final whistle that has the potential to change EVERYTHING!

Fluent Fiction - Swedish: Santorini Surprise: A Necklace's Journey of Friendship Find the full episode transcript, vocabulary words, and more:fluentfiction.com/sv/episode/2026-05-30-07-38-19-sv Story Transcript:Sv: Solen sken starkt över Santorini den här vårdagen.En: The sun shone brightly over Santorini on this spring day.Sv: Maja och Albin vandrade genom den livliga medelhavsmarknaden.En: Maja and Albin walked through the bustling Mediterranean market.Sv: Runtomkring dem doftade det av oliver, kryddor och solvarma tomater.En: Around them, the air was filled with the scent of olives, spices, and sun-warmed tomatoes.Sv: Smala, kullerstensgator fylldes av både turister och greker som njöt av det behagliga vädret.En: Narrow, cobblestone streets were filled with both tourists and Greeks enjoying the pleasant weather.Sv: Albin, som älskade att resa och samla på unika fynd, hade ett särskilt mål i sikte.En: Albin, who loved to travel and collect unique finds, had a specific goal in mind.Sv: Maja, däremot, letade efter en speciell gåva till sin syster Elin.En: Maja, on the other hand, was looking for a special gift for her sister Elin.Sv: Elin älskade kulturföremål, men hon hade sagt till Maja att inte stressa över en present – "En symbolisk gåva räcker", hade hon sagt.En: Elin loved cultural items, but she had told Maja not to stress about a present – "A symbolic gift is enough," she had said.Sv: När de vandrade från stall till stall, stannade Albin plötsligt.En: As they wandered from stall to stall, Albin suddenly stopped.Sv: Där, bland mängder av smycken, låg ett vackert traditionellt grekiskt halsband.En: There, among a multitude of jewelry, lay a beautiful traditional Greek necklace.Sv: Det lyste i solen, smyckat med blå emalj och små silverdetaljer.En: It gleamed in the sun, adorned with blue enamel and small silver details.Sv: Albin kände sitt hjärta slå snabbare.En: Albin felt his heart beat faster.Sv: Detta var den minnessak han sökte.En: This was the keepsake he sought.Sv: Men Maja hade också sett det.En: But Maja had also seen it.Sv: Hennes tankar snurrade – det skulle vara perfekt för Elins födelsedag.En: Her thoughts whirled—it would be perfect for Elin's birthday.Sv: Hon såg sig omkring.En: She looked around.Sv: Det var det sista halsbandet i sitt slag.En: It was the last necklace of its kind.Sv: Albin och Maja stirrade på varandra och insåg att de delade samma önskan.En: Albin and Maja stared at each other and realized they shared the same desire.Sv: De hade båda en begränsad budget och inget annat föremål på marknaden tilltalade dem på samma sätt.En: They both had a limited budget, and nothing else at the market appealed to them in the same way.Sv: Ingen av dem ville förstöra dagen för den andra.En: Neither of them wanted to ruin the day for the other.Sv: Som de grälade vänligt, dök en idé upp i Albins huvud.En: As they argued amicably, an idea popped into Albin's head.Sv: "Vi kan köpa det tillsammans", föreslog han, lite försiktigt.En: "We can buy it together," he suggested, a bit cautiously.Sv: Maja log, lättad över att han tagit initiativet.En: Maja smiled, relieved that he had taken the initiative.Sv: "Ja, varför inte?En: "Yes, why not?Sv: Vi kan dela på kostnaden."En: We can split the cost."Sv: Med bestämdhet närmade de sig säljaren, en livlig man som entusiastiskt började prata om halsbandet.En: With determination, they approached the vendor, a lively man who enthusiastically began talking about the necklace.Sv: Deras gemensamma erbjudande fick honom att skratta.En: Their joint offer made him laugh.Sv: "Dela både glädje och skönhet, det är klokt", sade han med en blinkning och accepterade deras pengar.En: "Sharing both joy and beauty, that's wise," he said with a wink and accepted their money.Sv: Efteråt satte sig Albin och Maja vid ett litet café med utsikt över det azurblå Egeiska havet.En: Afterwards, Albin and Maja sat down at a small café with a view of the azure Aegean Sea.Sv: De delade några baklava, den söta, krispiga skvättande dessert, och skrattade åt deras roliga stund vid marknadsståndet.En: They shared some baklava, the sweet, crispy, syrupy dessert, and laughed about their funny moment at the market stall.Sv: När de njöt av den sista tuggan, insåg Albin att det var värt mer att dela dessa ögonblick än att ta med sig en ensam souvenir hem.En: As they enjoyed the last bite, Albin realized that sharing these moments was worth more than bringing back a solitary souvenir.Sv: Maja upptäckte glädjen i att samarbeta, istället för att tävla.En: Maja discovered the joy of collaborating instead of competing.Sv: De tittade på halsbandet igen, nu deras gemensamma minne från Santorini.En: They looked at the necklace again, now their shared memory from Santorini.Sv: Under den soliga himlen kom de överens om att ibland är det finare att dela.En: Under the sunny sky, they agreed that sometimes it is nicer to share.Sv: De skulle turas om att bära halsbandet, varannan födelsedag, som en symbol för deras vänskap och det fina med att hitta en lösning tillsammans.En: They would take turns wearing the necklace, every other birthday, as a symbol of their friendship and the beauty of finding a solution together.Sv: Med marknadens sorl och havets brus i bakgrunden, slutade deras dag lika vacker som den hade börjat.En: With the market's chatter and the sea's murmurs in the background, their day ended as beautifully as it had begun. Vocabulary Words:bustling: livligacobblestone: kullerstenspleasant: behagligacollect: samlaunique: unikawandered: vandrademultitude: mängdergleamed: lysteadorned: smyckatkeepsake: minnessakwhirled: snurradestared: stirradeappealed: tilltaladeargued: gräladeamicably: vänligtcautiously: försiktigtinitiative: initiativetdetermination: bestämdhetvendor: säljarenenthusiastically: entusiastisktjoint: gemensammarelieved: lättadazure: azurblåbaklava: baklavasweet: sötcrispy: krispigasyrupy: skvättandesolitary: ensamcompeting: tävlasymbol: symbol

 “Failure to protect” charges are criminal prosecutions where one parent is accused of allowing another parent, or spouse, to abuse a child. For many, such as Deborah Albin, they may also be survivors of abuse, but are unable to raise that within their defense. Albin’s significant other, Andrew Oaks, is facing second-degree murder charges for their daughter Opal’s death. Andrew had previously threatened to kill Deborah and was accused by Albin of physically assaulting her. Despite this, courts are not allowing Albin to bring these incidents in her defense. This is part of a larger pattern of prosecutions against women using “failure to protect” laws.   Kaylee Tornay is an investigative reporter with Investigate West and has been following Deborah Albin’s case. She joins us to share more.  

Royal Pop, prestige och drömklockor på Stockholms AuktionsverkVad får ett av världens mest prestigefyllda klockhus att samarbeta med ett lekfullt och betydligt mer tillgängligt varumärke? I veckans avsnitt av Eqotime Podcast pratar Albin och Andreas om den oväntade satsningen bakom Royal Pop och försöker förstå vad samarbetet faktiskt betyder för Audemars Piguet. Handlar det om att nå nya kunder, skapa rubriker eller om något större kring framtidens lyxkonsumtion?Samtidigt riktas blicken mot Stockholms Auktionsverk och årets Fine Watch Sale. Vi går igenom auktionen, väljer våra personliga favoriter bland ovanliga och riktigt tunga objekt, och diskuterar varför vissa klockor fortsätter fascinera samlare långt efter att de lämnat butikshyllorna.I avsnittet diskuteras:• Royal Pop och varför samarbetet väcker så starka reaktioner• Vad Audemars Piguet faktiskt kan vinna på att utmana sin egen exklusivitet• Är detta framtiden för lyxklockor eller bara en tillfällig hype?• Höjdpunkter från Fine Watch Sale hos Stockholms Auktionsverk• Våra favoritobjekt från auktionen – från ikoniska samlarklockor till mer oväntade val Hosted on Acast. See acast.com/privacy for more information.

Gudstjänst

Au programme de l'émission du 13 mai : avec Sabine Zovighian, réalisatrice sonore, et Michael Liot, musicien (rediffusion) Pour commencer l'émission, éclairage sur les raisons de la grève des bibliothèques de la Ville de Paris la semaine dernière.▪️▪️▪️▪️Lire l'article d'Actualitté À FLEUR D'OREILLES - chronique de Laura Cattabianchi - c'est à 10 min✅Pour ce sixième épisode du projet mené cette année par Laura autour des sons de papier à l'Institut D'Education Sensorielle jeunes déficients visuels à Paris, les jeunes ont interviewé leur éducatrice Bénédicte. Elle a évoqué le son qu'elle aime et celui qu'elle n'aime pas ; puis, avec une feuille de papier qu'elle a choisi de chiffonner, elle a imaginé le début d'une histoire à partir du son produit..▪️▪️▪️▪️Site de l'IDESSPECTACLE - chronique de Véronique Soulé - c'est à 18 min✅Jean-Chat voit dans le noir est d'abord une histoire écrite et racontée par Sabine Zovighian sur un podcast en écoute depuis 2024 sur le site de Arte Radio. C'est aussi un album, illustré par Nathaniel H'limi (L'école des loisirs, 2024), et depuis la rentrée dernière, c'est également un spectacle. Un soir, un petit garçon part dans la ville à la recherche de son chat bien-aimé qui a disparu. Pour le retrouver il lui faudra apprendre à voir dans le noir et monter sur les toits de la ville.On retrouve dans le spectacle, une fiction sonore et dessinée, ce qui fait l'originalité du podcast : Sabine Zovighian raconte et bruite, en dialogue constant avec Grégoire Terrier derrière ses synthés et sa guitare, qui mêle compositions électro-acoustiques, sons doux et feutrés, bruitages, voix d'Hector, et une musique un rien mélancolique qui sied bien à la nuit, à la poésie et l'humour de l'histoire. Mais dimension supplémentaire, l'illustrateur Nathaniel H'limi, réalise en direct les dessins, projetés sur grand écran, dans une palette de bleus, de gris et de noirs.Dans ce spectacle doux et poétique, Sabine Zovighian sait drôlement bien capter l'attention et l'écoute des enfants, dès 3 ou 4 ans, par des sollicitations discrètes et des ruptures de rythme, tout comme le font l'image en train de s'esquisser sous leurs yeux, les bruitages, la musique, la chanson de Michael Liot qui revient en ritournelle. Tout l'imaginaire des enfants est en éveil !La dernière de la saison en région parisienne : mercredi prochain, 11 h, au théâtre de Vitry-sur-Seine. Dates de la prochaine saison à guetter sur le site de L'Armada productions.▪️▪️▪️▪️Site de L'Amarda Productions▪️▪️▪️▪️Site du théâtre Jean Vilar de Vitry-sur-SeinePODCAST - interview de Sabine Zovighian et Michael Liot (rediffusion) - c'est à 27 min✅ Sabine Zovighian est autrice et réalisatrice sonore de nombreuses fictions radiophoniques, en particulier jeunesse, pour Arte Radio d'abord, et depuis peu pour Radio France. L'année dernière, en avril, elle a adapté et réalisé, avec le musicien et compositeur Michael Liot, Les Malheurs de Sophie, qu'on a pu écouter sur les ondes de France Culture et disponible en podcast sur le site de Radio France. Une formidable comédie musicale, en 5 épisodes, qui dépoussière sacrément le roman de la comtesse.

Gudstjänst

In episode 145, Arian, Albin and Andre discuss the full slate from last weekend, including Carlstad's dominance down in Kristianstad, the exciting Stockholm derby, a low-scoring affair for our newcomers in Örebro, and an AIK no-show when Limhamn ran them off the field in Malmö. Then the guys get into the upcoming games, and make their predictions.

I dagens avsnitt får vi höra den spännande sagan "Jedi-Albin", önskad av Albin, 6 år från Sävedalen.Följ med Albin på ett galaktiskt äventyr! Mitt under ett spelpass sugs han plötsligt in i skärmen och landar i självaste Lego Star Wars. Där möter han mäster Yoda, som ger honom en grön lightsaber och ett viktigt uppdrag: för att öppna portalen hem måste han låsa upp tre magiska lås. Albin slåss mot kloss-droider och bygger höga legotrappor, innan han till slut ställs öga mot öga med Darth Vader. Men Albin inser att en riktig jedi inte alltid behöver besegra sin motståndare – ibland räcker det med att vara smart nog att ta sig förbi!I kvällens avsnitt firar vi Star Wars-dagen! "May the 4th be with you", som man brukar säga. Tobias övar på sin allra bästa (och mest burkiga) Darth Vader-röst, och Aida bjuder på otrolig bakom-kulisserna-fakta om hur man skapar ljudeffekter och filmtricks till rymdfilmer. Vi lär oss hur Chewbaccas legendariska röst skapades, att rymdskeppen från början byggdes av gamla plastleksaker och hur man lyckades få till andningsljudet för Darth Vader!Stötta podden och få tillgång till nya sagor! Gå med i Magiska Godnattsagor-klubben!Skicka in förslag på kommande sagor via www.magiskagodnattsagor.seSökord: magiska godnattsagor, godnattsaga, barn, läggdags, podcast för barn, barnlitteratur, ai, godnatt, star wars, may the 4th, lego, jedi

För drygt tio år sedan fick rapparen Albin Johnsén ett dundergenombrott med låten ”Min soldat”. Men vägen dit var allt annat än enkel. Han fick tidigt en destruktiv relation till alkohol och droger som fyllde det tomrum och självhat Albin kände inom sig. Det ledde också in honom på en kriminell bana som han hade svårt att ta sig ur.Livet som hyllad rappare med pengar, uppmärksamhet och utsålda spelningar blev en ny sorts knark. Tomheten och självhatet fanns kvar och en dag rasade allt.Idag har Albin Johnsén tagit steget in bakom scenen och är en i teamet bakom Mellovinnaren Felicia. Vi pratar också om vad Melodifestivalen betyder för svenskarna under årets mörkaste tid, vikten av vuxnas närvaro, gangsterrap, AIK, att sätta familjen först och vad Orminge och fritidsgårdarna betytt för Albin.Välkommen till ett samtal med många kloka tankar och reflexioner med rapparen och musikproducenten Albin Johnsén!Moderator: Gunnar OesterreichMusik: Mattias Klasson/Daniel OlsenDistribution: AcastSamarbetspartners: Life Genomics, Gröna Gårdar, FunmedHitta allt om podden: Websida: https://spannandemoten.se/Instagram: @spannandemotenFacebook: https://www.facebook.com/spannandemotenLinkedin: https://www.linkedin.com/in/gunnar-oesterreich/Kontakt: gunnar@oesterreich.se eller via sociala medier Hosted on Acast. See acast.com/privacy for more information.

I detta avsnitt av Eqotime Podcast rapporterar redaktionen från Watches & Wonders 2026.Andreas och Albin diskuterar mässan och allt omkring, klockorna som presenterats, möten och nyheter. Ni hittar alltid alla artiklar på Eqotime.com Hosted on Acast. See acast.com/privacy for more information.

Andakterna den här veckan tar avstamp i de fem världsreligionerna och har Våren som tema. Idag med prästen och psykoterapeuten Albin Tanke. Lyssna på alla avsnitt i Sveriges Radios app. Ur andakten:Påsken har kommit med sin återuppståndelse och livskraft! Den som våren just nu gestaltar för fullt med trädens knoppning, fågelsång och de vackra, ljusa morgnarna. Trots att allt detta nu har brutit igenom, så är det precis som om det inte riktigt når fram till mig.Vårens ljus har trängt igenom vintermörkret, värmen har vunnit kampen över kylan och livet har besegrat döden – varför har jag så svårt för att ta in detta budskap i min egen kropp? Det gäller ju även mig! Det är som om jag omedvetet håller fast vid vintermörkret och inte vågar släppa det. Som om jag är rädd för vad ”hoppet om det nya” ska innebära?Text:Höga Visan 2:11-12Musik:Prague's Ballet av Marius Neset med Marius Neset, Leif Ove Andsnes och Louisa TuckProducent:Susanna Némethliv@sverigesradio.se

I dagens avsnitt får vi höra den fina sagan "Trollet Krull och lejonet Leo", önskad av Albin, 5 år från Karlshamn.Följ med det lilla skogstrollet Krull och lejonet Leo som båda råkat gå vilse i den stora Vildmarksskogen under en vild lek. När de oväntat springer på varandra bland träden blir de först förskräckta, men upptäcker snabbt att de kan hjälpa varandra att hitta tillbaka. Genom att samarbeta hittar de inte bara hem till sina vänner, utan de upptäcker också att en vilsen promenad kan leda till en alldeles ny bästis! En varm och mysig berättelse om vänskap över gränserna.I kvällens avsnitt uppmärksammar vi Berätta en saga-dagen! Poddtrion försöker sig på leken att berätta en saga med ett ord i taget, vilket slutar i ett mycket märkligt äventyr om en anka med optimerad processorkraft. Dessutom lär vi oss spännande fakta om polisbilar, önskat av lyssnaren William! Vi tar reda på varför svenska polisbilar är blågula, hur världens snabbaste polisbil ser ut och det fantastiska faktumet att den allra första polisbilen var en elbil.​Stötta podden och få tillgång till nya sagor! Gå med i Magiska Godnattsagor-klubben!​Skicka in förslag på kommande sagor via www.magiskagodnattsagor.seSökord: magiska godnattsagor, godnattsaga, barn, läggdags, podcast för barn, barnlitteratur, ai, godnatt, troll, lejon, vänskap, polisbilar.

Patty highlights the Spring Indian Taco Supper April 27th on WRAM.

Man gönnt sich ja sonst nichts. Während die Branche zwischen Buchungsflaute und Preisschock balanciert, traf sich der DRV zur Jahrestagung auf den Azoren. Mitten im Atlantik, wo der Wind bekanntlich etwas rauer weht – eigentlich das perfekte Biotop für einen Mann, der seit kurzem am Ruder des Verbandes steht. Ich konnte Albin Loidl nach seiner ersten Keynote als DRV Präsident für den WAS MIT REISEN Podcast gewinnen, um mal unter die Oberfläche des „Überzeugungsoptimisten“ zu schauen. Vom Hurrikan Gilbert zum Verbands-Tornado Loidl ist kein Mann für das sanfte Gleiten im Sonnenuntergang. Er selbst bezeichnet sich im Gespräch fast schon kokett als „Schlechtwetterkapitän“. Und wer ihm zuhört, merkt schnell: Der Mann hat das Krisen-Gen. Ob er 1988 in Mexiko nach dem Hurrikan Gilbert den Gästen am weggeblasenen Strand von Yucatan erklärte, das Beste aus der neuen Realität zu machen oder nachts um zwei Uhr am Wiener Flughafen am lebenden Objekt einer 150-köpfigen Reisegruppe provisorisch und pragmatisch die Trümmer der Aero-Lloyd-Insolvenz zusammenkehrte – Loidl scheint das Chaos nicht zu fürchten, um zur Hochform aufzulaufen. Dass er nun ausgerechnet in einer Zeit den DRV übernahm, in der die Geopolitik nicht nur den Ferien-Flugplan diktiert, scheint fast schon Schicksal zu sein. Seine Botschaft an die Zweifler: Krisenbewältigung ist heute das eigentliche Pfund, mit dem die organisierte Reise wuchern kann. Urlaub als Luxusgut? Soziale Frage im Handgepäck Wir haben im Reiseradio-Podcast die Krise der Reisebranche besprochen, ohne uns an der aktuellen Kriegskrise abzuarbeiten: Die Passagierzahlen bröckeln, während die Umsätze nur dank der sehr stark gestiegenen Preise noch stabil aussehen. Loidl warnt deutlich: „Urlaub darf nicht zum Luxus werden“. Ein hehrer Wunsch, doch die Realität der Preisanstiege als „Gute-Laune-Killer“ lässt sich nicht einfach wegatmen. Er sieht das Reisen als stabilisierenden Faktor in einer global vernetzten Welt – fast schon eine diplomatische Mission. Doch wenn der innere Abstand vom Alltag für den Durchschnittsverdiener unbezahlbar wird, nutzt auch der schönste räumliche Abstand auf den Azoren wenig. Die Demokratisierung des Reisens steht auf dem Prüfstand. Boutique-Feeling statt Buchungs-Hieroglyphen Besonders spannend wird es, wenn wir über die Zukunft des klassischen Vertriebs sprechen. Loidl fordert einen Abschied vom Jammern über die digitale Konkurrenz. Seine Vision? Das Reisebüro als Boutique. Er liebt das Beispiel einer Kollegin aus Hamburg, die von ihrer Boutique-Besitzerin angerufen wird, weil die neue Herbstmode wahrscheinlich perfekt zu ihr passen würde. „Inspiration statt Preisvergleich“ lautet das Mantra. Dass dafür Künstliche Intelligenz kein nettes Extra, sondern die nackte Überlebensstrategie ist, lässt er keinen Moment bezweifeln. Wer heute noch nur Buchungsmasken ausfüllt, hat gegen den Algorithmus schon verloren. Strategieprozesse im Maschinenraum des Verbands Auch intern weht ein neuer Wind. Der DRV rüttelt an seinen eigenen Grundfesten. Ob die alte Säulenstruktur noch zeitgemäß ist oder ob sich die „Säule E“ der Digitalen nicht längst mit den klassischen Playern vermischt hat, ist Teil eines laufenden Strategieprozesses. Loidl gibt sich hier diplomatisch, lässt aber durchblicken, dass Stillstand keine Option ist. Die Branche dürfe sich nicht im Jammern über digitale Konkurrenz verlieren, sondern müsse die Digitalisierung als gemeinsames „Erbrecht“ begreifen. Fazit: Ein Optimist mit Realitätssinn Am Ende bleibt das Bild eines Präsidenten, der den „Überzeugungsoptimismus“ zur Maxime erhebt. Nicht aus Naivität, sondern mangels Alternative. Die Botschaft der Azoren-Tagung ist klar: Die Reiselust ist ungebrochen, doch die Branche muss lernen, in einer dauerhaft volatilen Welt zu navigieren. Ob das Prinzip Hoffnung reicht, um die steigenden Kosten und geopolitischen Tornados zu überstehen, bleibt die spannende Frage der nächsten Monate. Eines steht fest: Der Schlechtwetterkapitän mit der sanften Stimme möchte das Steuer fest in die Hand nehmen. Um den Podcast mit Albin Loidl zu hören, bitte auf das Kopfhörer-Symbol im Titelbild klicken Der Beitrag Schlechtwetter-Kapitän im Atlantik DRV-Präsident Albin Loidl und das Prinzip Hoffnung erschien zuerst auf Was mit Reisen.

Gudstjänst - Vårfest!

Novel MRI biomarkers, including cortical lesions, the central vein sign, and paramagnetic rim lesions, are highly specific for MS and can aid diagnosis in select clinical scenarios, particularly early in the disease course or in atypical presentations. When used with appropriate MRI sequences, these markers can improve diagnostic sensitivity while helping prevent misdiagnosis. In this episode, Casey Albin, MD, speaks with Jiwon Oh, MD, PhD, FRCPC, FAAN, author of the article "Diagnostic Neuroimaging Biomarkers for Multiple Sclerosis" in the Continuum® April 2026 Multiple Sclerosis and Related Disorders issue. Dr. Albin is a Continuum® Audio interviewer, associate editor of media engagement, and an assistant professor of neurology and neurosurgery at Emory University School of Medicine in Atlanta, Georgia. Dr. Oh is the medical director of the Barlo Multiple Sclerosis Program at St. Michael's Hospital and an associate professor at the University of Toronto in Toronto, Ontario, Canada. Additional Resources Read the article: Diagnostic Neuroimaging Biomarkers for Multiple Sclerosis Subscribe to Continuum®: shop.lww.com/Continuum Earn CME (available only to AAN members): continpub.com/AudioCME Continuum® Aloud (verbatim audio-book style recordings of articles available only to Continuum® subscribers): continpub.com/Aloud More about the American Academy of Neurology: aan.com Social Media facebook.com/continuumcme @ContinuumAAN Host: @caseyalbin Full episode transcript available here Dr Albin: Spend any time in a neurology conference, and you are certain to hear about the new central vein sign, which, as I learn, is not actually all that new. But have you heard about cortical lesions or these paramagnetic rim lesions? Because today I have the privilege of talking to Dr Jiwon Oh about her article, and we're going to unpack all these new biomarkers in MS. Dr Jones: This is Dr Lyell Jones, editor in chief of Continuum. Thank you for listening to Continuum Audio. Be sure to visit the links in the episode notes for information about earning CME, subscribing to the journal, and exclusive access to interviews not featured on the podcast. Dr Albin: Hello, this is Dr Casey Albin. Today I'm interviewing Dr Jiwon Oh about her article on diagnostic neuroimaging biomarkers for Multiple Sclerosis, which appears in the April 2026 Continuum issue on multiple sclerosis. Welcome to the podcast. Thank you so much for being here. I'd love to start by having you introduce yourself to our listeners.  Dr Oh: Thanks, Casey. Hi, everybody. My name is Jiwon Oh and I'm a neurologist, mainly an MS specialist at Saint Michael's Hospital at the University of Toronto, and I'm the medical director of our MS program. Dr Albin: And you have written a really fantastic article that dives deep into some of the nitty gritty about these new diagnostic biomarkers that we find on the MRI that we're getting for our patients with multiple sclerosis. And I think we are going to get into a lot of that nitty gritty. How do we look for them? How do they improve our diagnostic specificity? This is really come a long way in shaping the advances for multiple sclerosis. And I'd kind of like to just start with the big picture. Like why do we need these more specific biomarkers?  Dr Oh: This set of diagnostic criteria in MS, it's actually a huge change in the field, and particularly for people like me who are really interested in developing new MRI measures, we're really, really excited because it's actually the first time since MRI was officially incorporated into the MS Diagnostic criteria, which was way back in 2001. It's the first time that we've actually been able to get newer, more advanced imaging measures beyond just simply detecting, new T2 lesions in the MS diagnostic criteria. So, it's a big moment in the field, and many of us are really excited about it in terms of why we need some of these newer, more specific imaging measures. Well, you know, diagnostic criteria always evolve over time for any disease state, and MS is one that we've recognized over the years. By the time someone actually presents with typical clinical symptoms and has diagnosed, whatever has been happening from a patho-biological standpoint has been happening probably for almost 5 to 10 years before that individual actually presents. And so, because of this recognition in the field and the fact that we're recognizing how important it is to first diagnose MS and then treat MS earlier and earlier, because we know that early treatment helps prevent more clinical outcomes. Diagnostic criteria over time have become much more permissive, meaning that we're doing everything that we can to try to facilitate a diagnosis of MS when we know that someone biologically has MS. But the problem with making diagnostic criteria more permissive, and it's obviously a good thing because you want to capture as many people with MS as early on as possible. The problem with making it permissive is there is this terrible risk of misdiagnosis. As clinicians, we all think we never make mistakes. But it turns out when you actually do studies, you do. And even at MS specialty centers, when studies have been done, 10% to 20% of people with MS are misdiagnosed. So, this is exactly why we need in diagnostic criteria that really help to facilitate a diagnosis. We need things that help us prevent misdiagnosis as well. And these are these specific imaging measures that have now been incorporated into the diagnostic criteria in many settings that will help to facilitate a diagnosis. But the really big perk is if you use them, you can help to prevent misdiagnosis as well.  Dr Albin: Yeah, that really shone through in your article that this was such a big step in towards being more specific about who were diagnosing. Also capturing more people, right? Trying to get those people that we, we don't want to miss because of all the things you say, you know, that allows them to accumulate more disability, have worse outcomes. Early diagnosis is so important. But I really did take away from your article just how critical these are and sharping our diagnostic acumen. And so just to jump right in, and you describe these three new biomarkers, these cortical lesions the central vein sign and paramagnetic rim lesions. And so just to kick things off let's start with cortical lesions I sort of conceptualize multiple sclerosis a disease of white matter. So, what's going on here?  Dr Oh: Yes. MS classically has always been described as a white matter disease. But it turns out when you look at brain and spinal cord tissue, as well as when you use kind of better sequences to actually look for lesions in the gray matter, it actually turns out there's a ton of lesions in the gray matter as well. And in fact, what's interesting is that regardless of whether it's the cortex or the deep gray matter, it's lesions within these areas that seem to have the highest relevance for clinical disability in MS. So, all this to say, of course, MS is a lesion that does affect white matter, but it also affects gray matter a lot. And maybe pathology within the gray matter is even more relevant to clinical disability. So, this is why we're really interested in being able to develop methods using MRI to more accurately visualize the gray matter, particularly the cortex, as well as deep gray matter structures like the thalamus. I should add the caveat that cortical lesions were actually included in the 2017 diagnostic criteria revisions, but they were included together with juxtacortical lesions, which are a typical area that MS lesions form. And so, this imaging measure, despite the fact that it is relatively novel and we consider it advanced, it hasn't been used that much only because it's not that easy to detect lesions within the cortex. And reasons for this include that you usually need higher field magnet platforms. And so, the typical clinical MRI scanners that are available kind of widely, regardless of whether you're at an academic center or a community center, are 1.5 Tesla magnets. And cortical lesions are actually really difficult to detect on those typical scanners. But when you get to like, say, three Tesla or seven Tesla, they're a lot easier to detect. But obviously that's a big hindrance to widespread use. And then you actually need very specialized sequences to adequately visualize cortical lesions. And these are not sequences that are usually collected for clinical purposes. So, it kind of requires convincing your radiologists that you need this additional sequence. And then it actually takes a lot of time and training to be able to adequately, accurately detect cortical lesions. So, despite the fact that it's actually very useful when you do have the appropriate MRI sequences and scanners to detect cortical lesions, even though they were incorporated into the 2017 criteria outside of specialty centers, they're not actually widely used. But when you do have the appropriate sequences, cortical lesions are actually pretty specific for MS. So, very helpful for a diagnosis in certain settings. But there's all these practical limitations that have really limited its widespread use. Dr Albin: That is a beautiful summary. So, it sounds like once we kind of get up to speed in terms of like the protocols for this, having the magnet strength for this, this will be really a game changer in terms of increasing the specificity and also maybe finding things that impact patient's clinical presentation and therefore quite meaningful. But it sounds like for most of us, this is probably not something that they're going to be adopting right away. Is that a fair assessment?  Dr Oh: Yes. And you know, they were included in the last diagnostic criteria revisions. And it really hasn't changed things very much, only because of these difficulties with, you know, requiring higher field magnet strengths and these specialized sequences and then needing training to kind of figure out how you can adequately detect cortical lesions. Dr Albin: Totally. So, the other thing we've heard a lot about, and I have to say, I was in the AAN fall conference not too long ago, and this came up quite a bit, was the central vein sign and the fascination with that, because it tells us a lot about the MS pathophysiology and again, increasing that specificity. And it seems like maybe this is one that we can more easily adopt in clinical practice. So, tell our listeners about what that is, how they detect it. How many do you need to find?  Dr Oh: Sure. And so, this is one of the imaging measures I'm really excited about. So, the central vein sign heard about it recently. And probably in the last ten years particularly in the MS field we're talking about it all the time. But just wanted to emphasize that the central vein sign is not something that is new. Even back in the 1800s, when Charcot described MS lesions in these ancient textbooks, he actually very clearly described that MS lesions form around the central vein. And that makes sense, because we know that these waves of peripherally mediated inflammation somehow get through the blood-brain barrier and cause this cascade of events leading to inflammation in the brain and spinal cord, which is what MS is. But we know that B cells in T cells require veins to get into the central nervous system. And so, it's no surprise, really, that MS lesions form around veins. And so, this is something that's been known pathologically. But the reason we're so excited about it now is because we actually have good enough iron-sensitive MRI sequences that allow us to see a central vein when it is present within a white matter lesion. As a neurologist, we know that there's probably hundreds and hundreds of different things that can cause white matter lesions in the brain. But when you use an appropriate iron-sensitive sequence and you see that many of them, if not most of them, actually have visible central veins, that tells you that this person very likely has MS. And so that's why we're so excited about it, because there have been many studies done in the last ten years. In fact, so much evidence generated in the last ten years that there have been I think it's now four systematic reviews and meta analyzes. Looking at the diagnostic properties of the central vein sign. And, you know, it turns out that when you look at people with MS, most of them have a pretty high proportion of white matter lesions that have visible central veins. And there's a lot of questions about, you know, how to best use the central vein sign. But when 40% or more of the white matter lesions that you see have visible central veins, then the likelihood of a diagnosis of MS is very high. So, this is why we're so excited about it in the MS field because it's a really useful diagnostic tool. You know, again when you have appropriate ion sensitive sequences, if you see someone with white matter lesions and you see that 40% or more of them have visible central veins, this tells you that this person very likely has MS.  Dr Albin: So, Dr Oh, I hear you say, you know, 40% of the lesions. Does that mean the neuro radiologist needs to look at every single lesion and then count how many have the central veins, or is there an easier way to do this? Dr Oh: Great question. Casey, there is definitely an easier way because our neuro radiologists would not be our friends anymore if we made them look at every white matter lesion and make sure that 40% of them had the central vein sign. So, because it's so time-consuming to use that 40% threshold, there's an easier criterion that has actually made it into the diagnostic criteria. And it's called Select Six. And what this means is when you have more than ten lesions, as long as you show that six of them have a visible central vein, you just have to count six with the central vein. Then you're done. So that means you're Select Six positive or central veins nine positive. However, if you have ten or fewer lesions, as long as you show that more than 50% of them show a visible central vein, then you are select six positive, and then you're done. So, as you can see, it's a much simpler criterion to apply, and it seems to perform almost as well as that 40% threshold, which is why that is the criterion that's made it into the new diagnostic criteria.  Dr Albin: Perfect. I love that we definitely do not want to make enemies with our neuro radiology colleagues, but yet they do so much for us. So perfect. I'm glad that we can, make their jobs a little easier without losing any specificity there, or just losing a touch of specificity there. All right. If I am working with a, you know, in a center that maybe doesn't do this all the time, am I just getting a run of the mill SWI sequence? Do I need to ask my radiologist for a special sequence? Or is this just, you know, you can get it from the typical array of what our patients are getting.  Dr Oh: You know, SWI is a widely available commercial sequence that's iron-sensitive, the ones that are typically commercially available, they can detect central veins, but there actually are little tweaks that you can do to make it a little more optimal. With the recent diagnostic criteria publication, which was, led by Xavier Montalban and recently published in Lancet Neurology. There's actually a companion MRI paper that was led by Frederick Barkov and Danny Wright. And the reason I'm specifically citing those papers is in that companion MRI paper, there's a table that has kind of optimal sequence parameters that you can use even with a conventional SWI sequence, to try to best detect the central vein sign. And then there's a wide range of different iron-sensitive sequences, and SWI is one of them, but the one that seems to have emerged as most sensitive to detect the central vein sign is something called the 3D T2*-EPI sequence. But the bottom line is there's a whole bunch of different iron-sensitive sequences that you can use, little tweaks that you can do to make them optimal, to be able to visualize central veins when they're present within white matter lesions. Dr Albin: Incredible. So like partner with your neuro radiologist, there is a great sounds like a field guide almost to this. So, it makes it easy to pick up in your standard of care so that you can make sure that you are detecting them at the optimal level to see that more specific diagnostic biomarker.  Dr Oh: Yes. And you know, in contrast to what we were talking about with cortical lesions, you can actually detect central veins when you use these iron-sensitive sequences at any field magnet. So even at 1.5 Tesla, particularly when you use contrast, which is often given with the diagnostic scan anyway, you can very easily detect a central vein. So that's a huge benefit because it allows for widespread use. As long as you work with your radiologist to get the right iron-sensitive sequences in.  Dr Albin: Yeah, that's incredible. I mean, I think that it really will be practice-changing. And then the last one that I think was honestly new to me, I feel like I had heard a lot about the central vein sign, but the whole new to me term was this paramagnetic rim lesion. So, what does that tell us about the underlying biology of MS? And are there any other things that might also have this finding that we should sort of be aware of? And how specific is it?  Dr Oh: You know, the central vein sign is kind of the main, really new imaging measure that's made it into every part of the MS diagnostic criteria. And then together with that paramagnetic rim lesions or we call them PRL or pearls for short, they've made it as well, but in a much more limited way only because there's not as much evidence that has accumulated over time to support the diagnostic utility of pearls. But first of all, what are pearls? So, people in the MS field are really excited about pearls, because we know that they capture a subset of what we call chronic active lesions. So, MS lesions will form acutely and over time, some of them will become inactive. And then some of them are chronic active lesions, meaning that they have this rim of activated microglia around them. Over time, they continue to slowly expand. And it's almost like this slow burn. And the reason why we focus a lot on chronic active lesions is because we know that they're a driver of progressive disease biology and MS, meaning that in people who have progressive MS or who have pretty severe disability, global disability or cognitive disability, we know that they have a high burden of pearls. And so that's why there's so much excitement in MS about being able to image chronic active lesions. It's because we're always looking for an imaging measure that allows us to accurately predict progression or to, measure progression over time. So that's why there's so much excitement in MS about pearls. But as kind of an added bonus, it turns out pearls are also really specific for MS. And so, when you use the same iron-sensitive sequences, by the way, that's used to detect the central vein sign when you use appropriate iron‑sensitive sequence. And if you see that someone has a pearl, the likelihood of a diagnosis of MS is very high. The one exception to that is Susac syndrome, where pearls have been observed. But other than that, with many other white matter diseases like neuro rheumatology disease, NMOSD, MOGAD, you really don't see pearls. And so, this is why it's made it into the new diagnostic criteria. In contrast to the central vein sign, though, not everybody with MS has a pearl, so the sensitivity isn't as high. However, it's really, really specific in the range of, you know, 90 to 95%. So, this is why it's been added as, an imaging measure in certain settings. It can help facilitate a diagnosis. But the real utility, again, is when you use it, it helps you to prevent misdiagnosis.  Dr Albin: It's fantastic. And hearing you talk about that, this one stands out to me as a biomarker that not only helps increase our diagnostic specificity, but also may really inform if the patient has having progression despite the treatment they're on, that this could play a role in helping you say, look, there probably is something that we need to switch because we can still see this ongoing progression. Dr Oh: Yes. And especially in this new era of treatment in MS. I think, you know, MS as a field, we've been so fortunate to have so many treatments emerge over the years that mainly target relapsing disease. But we hopefully, in the next little while, in short order, I hope we'll have treatments that target these progressive disease biologies. And so, not only is it helpful as a diagnostic marker, but there's a lot of evidence accumulating, showing that it may have a lot of prognostic value and will also help guide treatment decisions, exactly as you said.  Dr Albin: It truly does sound like it's a great time to be an MS doctor there. So, so many new advances in the field. There is so much more that we can do for these patients in our limited time left. I'd love to ask you, what is it that you're most excited about now with the change in the biomarkers, the change in the treatment, what makes you really excited to be a doctor specializing in MS right now? Dr Oh: I feel like we're on the brink of a new era of treatment. I think, you know, in the last two decades, MS care has changed so dramatically. I remember, you know, way back when, as a medical student, when I did my first neurology elective, this was when the first treatments for MS were emerging. And the prognosis that we were talking to patients about at that time is like night and day compared to what we talk to them about now. But we're going to do even better in the next couple of years. And so, there's a number of new treatments that hopefully will be approved soon that, for the first time, have shown an effect in clinical trials where it seems to be decreasing progression that is independent of relapsing activity. And that's really the greatest unmet treatment need that we have. And it seems like we might have some therapies on the horizon that can actually target that aspect of progression. It's really exciting, and even more that we're going to be able to do for our patients to completely change the way, we look at and the way we treat MS in the years to come.  Dr Albin: Dr Oh, this has just been fantastic. To all of our listeners, I really want to point you to the article because obviously, as an imaging biomarker article, there are so many beautiful images. There are great examples. There are some fantastic cases that show how applying these new biomarkers can help get you to the right diagnosis. This is truly a tour de force of how imaging has really shifted the care that we provide patients with MS, and so please go and check it out. It is one that you do not want to miss. And again, today I've been interviewing Dr Jiwon Oh about her article on diagnostic neuroimaging biomarkers for multiple sclerosis, which appears in the April 2026 Continuum issue on multiple sclerosis. Thank you again, Dr Oh, this has just been such a delight.  Dr Oh: Thank you for having me on the show, Casey, and look forward to people reading the article. Dr Monteith: This is Dr Teshamae Monteith, associate editor of Continuum Audio. If you've enjoyed this episode, you'll love the journal, which is full of in-depth and clinically relevant information important for neurology practitioners. Use the link in the episode notes to learn more and subscribe. AAN members, you can get CME for listening to this interview by completing the evaluation at continpub.com/audioCME. Thank you for listening to Continuum Audio.

Fluent Fiction - Swedish: Spring Confessions: A Dance of Hearts in Uppsala Find the full episode transcript, vocabulary words, and more:fluentfiction.com/sv/episode/2026-04-07-07-38-19-sv Story Transcript:Sv: Våren var i full blom i Uppsala.En: Spring was in full bloom in Uppsala.Sv: Solen värmde skolans gula tegelväggar och träden hade redan fått sina gröna knoppar.En: The sun warmed the school's yellow brick walls, and the trees had already sprouted their green buds.Sv: Skoldansen skulle hållas i gympasalen, som var dekorerad med pastellfärgade pappersgirlanger och stora påskägg.En: The school dance would be held in the gymnasium, which was decorated with pastel-colored paper garlands and large Easter eggs.Sv: Musik hördes långt bort i korridorerna, och många elever samlades för att avsluta skolveckan med en festlig kväll.En: Music was heard far down the corridors, and many students gathered to end the school week with a festive evening.Sv: Albin ställde sig vid ingången till gympasalen.En: Albin stood at the entrance to the gymnasium.Sv: Han var nervös.En: He was nervous.Sv: Han såg sig omkring och letade efter Sigrid.En: He looked around and searched for Sigrid.Sv: Hon stod vid ett bord längst bak i salen, och i hennes närhet fanns Nils.En: She stood by a table at the back of the hall, and nearby was Nils.Sv: Nils var en god vän, men ibland gjorde hans självsäkra retsamhet det svårt för Albin.En: Nils was a good friend, but sometimes his confident teasing made things difficult for Albin.Sv: "Har du skrivit kortet?"En: "Have you written the card?"Sv: frågade Nils och puttade Albin i sidan.En: asked Nils, nudging Albin in the side.Sv: "Ja," svarade Albin tyst och rodnade.En: "Yes," replied Albin quietly, blushing.Sv: Kortet, ett anonymt påskkort, fanns gömt i Sigrids skåp tidigare samma dag.En: The card, an anonymous Easter card, had been hidden in Sigrid's locker earlier that day.Sv: Albin mindes hur han hade suttit uppe kvällen innan för att skriva kortet med sina känslor.En: Albin remembered how he had stayed up the night before to write the card with his feelings.Sv: "Glad Påsk," hade han börjat, följt av några nervöst formulerade rader om hur mycket han tyckte om henne.En: "Happy Easter," he had started, followed by a few nervously phrased lines about how much he liked her.Sv: Nils fnissade.En: Nils snickered.Sv: "Du borde bara spela det cool."En: "You should just play it cool."Sv: Albin tvekade i dörröppningen.En: Albin hesitated in the doorway.Sv: Han visste att detta var hans chans.En: He knew this was his chance.Sv: Han kunde höra musiken och skratten, men hans hjärta slog så hårt att ljudet av musik nästan överröstades.En: He could hear the music and laughter, but his heart was pounding so hard that it almost drowned out the sound of the music.Sv: Plötsligt såg han Sigrid gå mot honom.En: Suddenly, he saw Sigrid walking toward him.Sv: Hon log, och något i hennes ögon sa att hon visste.En: She smiled, and something in her eyes said that she knew.Sv: När hon kom närmare höll hon upp kortet med ett leende.En: As she came closer, she held up the card with a smile.Sv: "Var det du som skrev detta?"En: "Was it you who wrote this?"Sv: frågade hon försiktigt, men det fanns en glimt av förväntan i hennes röst.En: she asked cautiously, but there was a hint of anticipation in her voice.Sv: Albin kände hur kinderna brann.En: Albin felt his cheeks burn.Sv: Här var beslutet.En: Here was the decision.Sv: Han kunde säga att det var ett skämt och gå vidare, eller han kunde satsa allt och säga sanningen.En: He could say it was a joke and move on, or he could risk everything and tell the truth.Sv: Med ett djupt andetag mötte han hennes blick.En: With a deep breath, he met her gaze.Sv: "Ja, det var jag," sa han tillslut, övervinnande rädslan som burit på honom så länge.En: "Yes, it was me," he finally said, overcoming the fear that had burdened him for so long.Sv: "Jag har velat säga det länge.En: "I've wanted to say it for a long time.Sv: Jag gillar dig, Sigrid."En: I like you, Sigrid."Sv: Sigrid log stort nu, och det var ett leende som fick hans mod att växa.En: Sigrid was smiling broadly now, and it was a smile that made his courage grow.Sv: "Jag är glad att du sa det," svarade hon.En: "I'm glad you said it," she replied.Sv: "Jag har hoppats att du skulle fråga mig."En: "I was hoping you would ask me."Sv: De tog varandras händer och gick ut på dansgolvet.En: They took each other's hands and stepped onto the dance floor.Sv: Musikens rytm fyllde gympasalen, och de dansade under de mjuka ljusen och de färgglada dekorationerna.En: The rhythm of the music filled the gymnasium, and they danced under the soft lights and the colorful decorations.Sv: För Albin var det som om världen runt honom försvann.En: For Albin, it was as if the world around him disappeared.Sv: Han hade tagit steget, vunnit över sina tvivel och var där med Sigrid.En: He had taken the step, conquered his doubts, and was there with Sigrid.Sv: När kvällen fortskred, insåg Albin att sanningen, även om den ibland kunde kännas läskig, hade gett honom mer än han någonsin kunnat hoppas på.En: As the evening went on, Albin realized that the truth, even if sometimes it felt scary, had given him more than he could ever have hoped for. Vocabulary Words:bloom: blomsprouted: fåttgymnasium: gympasalengarlands: pappersgirlangercorridors: korridorernagathered: samladesfestive: festlignervous: nervösblushing: rodnadeanonymous: anonymtphrased: formuleradelaughter: skrattenpounding: slogdrowned out: överröstadesanticipation: förväntancautiously: försiktigtgaze: blickburdened: buritconquered: vunnit överdoubts: tvivelrealized: insågtruth: sanningenscary: läskigwarmed: värmdeconfident: självsäkrateasing: retsamhetsnickered: fnissadehesitated: tvekadebroadly: stortcourage: mod

Äntligen är det här, avsnittet då vi nördar ner oss i fjädring. Med mig har jag Albin Kumlin från Kumlin Suspension. Lämna gärna en kommentar om ni gillar avsnittet.

Påskdagens Gudstjänst

Fluent Fiction - Swedish: Facing Fears and Finding Friendship at the Akropolis Find the full episode transcript, vocabulary words, and more:fluentfiction.com/sv/episode/2026-03-30-07-38-19-sv Story Transcript:Sv: Den varma vårsolen sken klart över Akropolis i Aten.En: The warm spring sun shone brightly over the Akropolis in Aten.Sv: Linnea, Albin och Saga hade beslutat sig för att utforska denna historiska plats tillsammans.En: Linnea, Albin, and Saga had decided to explore this historical site together.Sv: Linnea, en blyg men vetgirig student i historia, hade en målsättning.En: Linnea, a shy but curious history student, had a goal.Sv: Hon ville få ny insikt om det antika Greklands historia för sin avhandling.En: She wanted to gain new insights into ancient Greece's history for her thesis.Sv: Albin, en modig resenär, kämpade med sin hemliga rädsla för höga höjder.En: Albin, a brave traveler, was struggling with his secret fear of heights.Sv: Saga, en empatisk konstnär, sökte inspiration till sina målningar.En: Saga, an empathetic artist, sought inspiration for her paintings.Sv: De tre vännerna vandrade upp för den steniga vägen till Akropolis.En: The three friends walked up the rocky path to the Akropolis.Sv: Omgivningen var fylld med andra turister som också ville uppleva historiens vingslag.En: The surroundings were filled with other tourists who also wanted to experience the wings of history.Sv: De majestätiska marmorkolonnerna reste sig mot den klara, blå himlen.En: The majestic marble columns rose against the clear blue sky.Sv: Akropolis var verkligen en syn att skåda.En: Akropolis was truly a sight to behold.Sv: Linnea kände sig lite osäker.En: Linnea felt a bit uncertain.Sv: Hon ville fråga Albin och Saga om deras åsikter om de olika historiska artefakterna, men hennes blyghet höll henne tillbaka.En: She wanted to ask Albin and Saga about their opinions on the various historical artifacts, but her shyness held her back.Sv: Samtidigt försökte Albin hålla sin panik i schack.En: Meanwhile, Albin was trying to keep his panic at bay.Sv: Han såg upp mot Parthenon-templets höga pelare och kunde känna det familjära pirret av skräck i magen.En: He looked up at the tall pillars of the Parthenon temple and could feel the familiar flutter of fear in his stomach.Sv: Under vandringen märkte Saga att Albin började saktna efter.En: During the hike, Saga noticed that Albin was starting to lag behind.Sv: Hon lade märkte till hur han vitnade i ansiktet.En: She noticed how his face turned pale.Sv: "Albin, är du okej?En: "Albin, are you okay?"Sv: " frågade hon försiktigt.En: she asked cautiously.Sv: "Jag.En: "I...Sv: jag tror det," svarade han.En: I think so," he replied.Sv: "Men det är högre än vad jag trodde.En: "But it's higher than I thought."Sv: "Linnea hörde deras samtal och såg det här som en chans att hjälpa till.En: Linnea heard their conversation and saw this as a chance to help.Sv: Hon vände sig till Albin och sa, "Vi kan ta det lugnt.En: She turned to Albin and said, "We can take it easy.Sv: Jag har en karta och vi kan stanna när som helst.En: I have a map, and we can stop at any time."Sv: "Albin kände sig lättad av Linneas stöd.En: Albin felt relieved by Linnea's support.Sv: De tog ett ögonblick för att blicka ut över Aten.En: They took a moment to gaze out over Aten.Sv: Staden bredde ut sig som ett lapptäcke av vita byggnader och grönska.En: The city spread out like a patchwork of white buildings and greenery.Sv: När de nådde toppen, kände Albins rädsla sitt crescendos.En: When they reached the top, Albin's fear reached its crescendo.Sv: Men Linnea tog ledningen.En: But Linnea took the lead.Sv: Hon beskrev historian bakom Akropolis med en sådan passion att Albin kunde fokusera på hennes berättelse istället för höjden.En: She described the history behind Akropolis with such passion that Albin could focus on her story instead of the height.Sv: Sakta men säkert försvann hans rädsla.En: Slowly but surely, his fear faded away.Sv: De stod där tillsammans, Linnea, Albin och Saga, och såg ut över Aten.En: They stood there together, Linnea, Albin, and Saga, looking out over Aten.Sv: Solens strålar värmde deras ansikten, och en lätt bris smekte deras kinder.En: The sun's rays warmed their faces, and a gentle breeze caressed their cheeks.Sv: Det var en tyst stund fylld av förståelse och vänskap.En: It was a silent moment filled with understanding and friendship.Sv: Linnea insåg att hon inte bara hade lärt sig om det antika Grekland utan också om viktigheten av att öppna upp sig för andra.En: Linnea realized that she had not only learned about ancient Greece but also about the importance of opening up to others.Sv: Albin i sin tur, hade övervunnit en del av sin rädsla och kunde nu njuta av utsikten.En: Albin, in turn, had overcome part of his fear and could now enjoy the view.Sv: Saga fann sin inspiration i deras gemensamma upplevelse.En: Saga found her inspiration in their shared experience.Sv: När de började vandra ner för Akropolis, kände de sig alla lite förändrade.En: As they began to descend from the Akropolis, they all felt a little changed.Sv: Inte bara hade de fått kunskap om det förflutna, men de hade också skapat nya band med varandra.En: They had not only gained knowledge about the past, but they had also formed new bonds with each other.Sv: Det var en resa de sent skulle glömma.En: It was a journey they would not soon forget. Vocabulary Words:sun: solenthesis: avhandlingshy: blyginsight: insiktcurious: vetgiriggoal: målsättningfear: rädslaheights: höjderempathetic: empatiskinspiration: inspirationpath: vägmarble: marmorcolumns: kolonnernauncertain: osäkershyness: blyghetpanic: panikpillar: pelareflutter: pirretstomach: magencautiously: försiktigtrelieved: lättadsupport: stödbreeze: brisembrace: smekteunderstanding: förståelsejourney: resadescribed: beskrevpassion: passiongaze: blickashared: gemensamma

Andakterna den här veckan hålls av prästen och psykoterapeuten Albin Tanke från Malmö. Idag handlar andakten om mötet i vardagen. Lyssna på alla avsnitt i Sveriges Radios app. Ur andakten:Har du tänkt på att så många varhus idag har snurr-ingångar? Gamla vanliga dörrar finns knappt längre, utan det är de här stora snurrorna som det gäller att parera när vi går in i –och så leds vi långsamt runt utan att behöva se någon i ögonen på vår väg fram. I dessa snurr-ingångar slipper vi mötas och krocka. Vi går runt varandra och i mitten blir det tomt. Men vad händer där i centrum, i vårt innersta? Vad händer med blickar som aldrig möts och vad händer med oss om vi aldrig behöver korsa varandras vägar?Vi skulle kunna mötas och visa hänsyn när vi stöter ihop med varandra och kanske få syn på något som är till befrielse och till glädje? Att ta hand om den värme som avges när vi stöter ihop och liksom försöka leda den rätt, i kärlekens namn, kan kanske ge oanade möjligheter?Text:1 Joh 3:18-24Musik:Chess av och med Benny AnderssonProducent:Susanna Némethliv@sverigesradio.se

Andakterna den här veckan hålls av prästen och psykoterapeuten Albin Tanke från Malmö. Idag om ett viktigt ögonblick på ett konfirmandläger. Lyssna på alla avsnitt i Sveriges Radios app. Ur andakten:Vi satt på golvet i det vackra lilla kapellet, trettio konfirmander och några ledare. Det var lite trångt men rummet gav frid och ro. Det var sent och vi skulle har kvällsandakt en av de sista kvällarna på konfirmandlägret. Stearinljusen brann stillsamt som enda belysning i det gamla 1800-talskapellet. Tystnaden som lade sig i rummet när gitarren klingat ut den sista tonen, var magisk. Det var som ett förklarat ögonblick. Gemenskapen, orden, musiken, tystnaden och framför allt vänskapen som växt sig starkt under lägret, fick nog alla att känna att denna stund var helig, att liksom tiden stod still. Livet med en djup meningsfullhet sjönk in i oss alla – och det var som om tillgången till att verkligen kunna ta emot den frid som vi sjöng om, talade och bad om, verkligen öppnades för var och en.Text:Joh 15:12-17Musik:Chess av och med Benny AnderssonProducent:Susanna Némethliv@sverigesradio.se

Andakterna den här veckan hålls av prästen och psykoterapeuten Albin Tanke från Malmö. Temat för veckan är Vägar till liv. Lyssna på alla avsnitt i Sveriges Radios app. Ur andakten:Gymnasieskolans aula var fylld av elever. Fler hundra ungdomar hade samlats för en temadag om andlighet och tro. Jag var inbjuden som talare tillsammans med några andra religiösa företrädare. När vi ställde oss på scenen tog det inte lång stund för sorlet att tystna. Det var tydligt att ämnet vi skulle tala om engagerade ungdomarna. Frågorna från eleverna kom främst att handla om tillit, om meningen med livet och om det finns något liv efter döden? Jag tänkte att dessa frågor nog skulle komma upp, därför hade jag förberett mig och tagit med ett litet ägg för att åskådliggöra mina tankar om livet och döden. Ägget är en urgammal symbol för liv. Fylld med kraft sprängs gränserna för det redan kända. Livet som övervinner döden. Att det finns mer att se än det vi just nu kan fatta.När jag hade talat en stund så räckte en kille, som satt ganska långt fram, försiktigt upp sin hand och frågade lite trevande: ”Så du menar alltså att det kan betyda att det inte alltid behöver kännas i livet precis så som det känns just nu?” Text:Ps 16:11Musik:Chess av och med Benny AnderssonProducent:Susanna Némethliv@sverigesradio.se

Fluent Fiction - Swedish: Spring Revelations: A Heartfelt Journey at Gröna Lund Find the full episode transcript, vocabulary words, and more:fluentfiction.com/sv/episode/2026-03-21-22-34-01-sv Story Transcript:Sv: Gröna Lund var fyllt av vårens glädje och påskens färger.En: Gröna Lund was filled with the joy of spring and the colors of Easter.Sv: Det var en perfekt dag för att njuta av Stockholm i april.En: It was a perfect day to enjoy Stockholm in April.Sv: Elin, Albin och Sofia promenerade längsmed den livliga parken med skratt och glädje i luften.En: Elin, Albin, and Sofia strolled along the lively park with laughter and joy in the air.Sv: De såg sig omkring och kände doften av nybakat bröd och hörde sockervaddsmaskiner som surrade.En: They looked around and smelled freshly baked bread and heard the cotton candy machines whirring.Sv: Elin försökte att vara glad och njöt av dagen med sina vänner, men inom sig var hon orolig.En: Elin tried to be happy and enjoy the day with her friends, but inside she was worried.Sv: Den envisa hostan hade följt henne i flera veckor.En: The persistent cough had followed her for several weeks.Sv: Ibland kände hon sig så trött att hon knappt kunde koncentrera sig på de roliga karusellerna.En: Sometimes she felt so tired that she could barely concentrate on the fun rides.Sv: De tre vännerna stannade vid ett stånd och åt prasslande påskägg medan barnen runt dem letade efter godis i sina korgar.En: The three friends stopped at a stand and ate crackling Easter eggs while the children around them searched for candy in their baskets.Sv: Sofia märkte att Elin verkade lite disträ.En: Sofia noticed that Elin seemed a bit distracted.Sv: "Är allt okej, Elin?"En: "Is everything okay, Elin?"Sv: frågade hon försiktigt.En: she asked cautiously.Sv: Elin skrattade, men hostade snart igen.En: Elin laughed, but soon coughed again.Sv: "Jo, jag är bara lite trött," svarade hon och torkade en tår från ögat.En: "Yes, I'm just a little tired," she replied, wiping a tear from her eye.Sv: Albin böjde sig närmare.En: Albin leaned in closer.Sv: "Du vet att du kan prata med oss, eller hur?"En: "You know you can talk to us, right?"Sv: sa han lugnt.En: he said softly.Sv: En stund senare satt de alla i en färgglad vagn på pariserhjulet.En: A moment later, they were all sitting in a colorful carriage on the Ferris wheel.Sv: Hjulet började röra sig sakta upp mot den klara vårhimlen.En: The wheel began to move slowly up towards the clear spring sky.Sv: Det var något med den lugna utsikten över Stockholm som gjorde Elin modigare.En: There was something about the calm view over Stockholm that made Elin braver.Sv: "Jag har något att berätta," sa hon plötsligt när de nådde toppen.En: "I have something to tell," she said suddenly when they reached the top.Sv: "Den här hostan... den oroar mig.En: "This cough... it worries me.Sv: Jag försöker att inte tänka på det, men jag kan inte låta bli att undra."En: I'm trying not to think about it, but I can't help but wonder."Sv: Albin lade sin hand på hennes axel.En: Albin placed his hand on her shoulder.Sv: "Det är bra att du berättar.En: "It's good that you're telling us.Sv: Vi finns här för dig."En: We're here for you."Sv: Sofia nickade.En: Sofia nodded.Sv: "Vi kanske ska besöka en läkare.En: "Maybe we should visit a doctor.Sv: Vi kan följa med dig."En: We can go with you."Sv: Elin kände en våg av lättnad skölja över sig.En: Elin felt a wave of relief wash over her.Sv: "Tack.En: "Thanks.Sv: Jag tror att jag behöver göra det," sa hon med ett svagt leende.En: I think I need to do that," she said with a faint smile.Sv: När hjulet långsamt nådde marken igen kände Elin sig lättare.En: As the wheel slowly reached the ground again, Elin felt lighter.Sv: Hon visste nu att hon hade stöd.En: She now knew she had support.Sv: Kanske var det dags att ta itu med sitt bekymmer på riktigt.En: Maybe it was time to really address her concern.Sv: Gröna Lund fortsatte att surra med energi när de lämnade pariserhjulet.En: Gröna Lund continued to buzz with energy as they left the Ferris wheel.Sv: Elin kramade Albin och Sofia, glad över att ha dem som vänner.En: Elin hugged Albin and Sofia, glad to have them as friends.Sv: Påsken handlade om nytt liv och hopp, och nu kände hon att det fanns nytt hopp för henne också.En: Easter was about new life and hope, and now she felt there was new hope for her too.Sv: De tre vännerna avslutade dagen med ett löfte: de skulle ta hand om varandra, oavsett vad.En: The three friends ended the day with a promise: they would take care of each other, no matter what.Sv: Det äventyret, precis som alla andra i deras liv, skulle de möta tillsammans.En: That adventure, just like all others in their lives, they would face together. Vocabulary Words:filled: fylltjoy: glädjecolors: färgerstrolled: promeneradelively: livligasmelled: kände doftenfreshly: nybakatwhirring: surradepersistent: envisbarely: knapptconcentrate: koncentreracrackling: prasslandedistracted: disträcautiously: försiktigtwiping: torkadetear: tårleaned: böjdecarriage: vagnbraver: modigaresuddenly: plötsligtplaced: ladewave: vågrelief: lättnadfaint: svagtlighter: lättaresupport: stödaddress: ta itu medconcern: bekymmerbuzz: surrapromise: löfte

Many serious medical illnesses are associated with some degree of serum electrolyte abnormality, renal impairment, or both. The neurologist must determine if the patient's neurologic symptoms are related to the renal and electrolyte disturbances or whether a concurrent primary neurologic process is at play. In this episode, Casey Albin, MD, speaks with Eelco F. M. Wijdicks, MD, PhD, FAAN, FACP, FNCS, author of the article "Neurologic Manifestations of Renal and Electrolyte Disorders" in the Continuum® February 2026 Neurology of Systemic Disease issue. Dr. Albin is a Continuum® Audio interviewer, associate editor of media engagement, and an assistant professor of neurology and neurosurgery at Emory University School of Medicine in Atlanta, Georgia. Dr. Wijdicks is a professor of neurology and attending neurointensivist for the Neurosciences Intensive Care Unit at Mayo Clinic in Rochester, Minnesota. Additional Resources Read the article: Neurologic Manifestations of Renal and Electrolyte Disorders Subscribe to Continuum®: shop.lww.com/Continuum Earn CME (available only to AAN members): continpub.com/AudioCME Continuum® Aloud (verbatim audio-book style recordings of articles available only to Continuum® subscribers): continpub.com/Aloud More about the American Academy of Neurology: aan.com Social Media facebook.com/continuumcme @ContinuumAAN Host: @caseyalbin Guest: @EWijdicks Full episode transcript available here

Här kommer ett kärleksbrev till dig, min kära lyssnare. En påminnelse om att romantik behövs och att den gör livet lite härligare. Och kanske viktigast av allt: romantik är något vi kan öva på, lite mer, varje dag.I det här avsnittet hyllar jag de små gesterna som gör störst skillnad och hur vi uppvaktar varandra i vardagen. Med mig har jag några personer jag tycker väldigt mycket om som delar sina tankar om romantik, kärleksbrev, presenter och romantisk mat.Du hör Ebba Kleberg von Sydow, Hanaw Rashid, Martin Hansson och Adam & Albin. Ett avsnitt om pirr, värme och valet att om och om igen bjuda in mer romantik i livet.

Why are Americans getting sicker, heavier, and more stressed? In this episode of The Ana Cruz Show, Ana Cruz talks with Dr. Jaclyn Albin, a pediatrician and lifestyle medicine expert, about how food impacts our body, mind, and overall health. They discuss what's missing from the average American plate, how processed foods fuel chronic disease and depression, and practical tips to eat smarter every day. Follow @‌anacruzshow on Instagram and TikTok for more, and visit www.rollosdemujeres.com for updates and resources! Check out more of Dr. Albin's work on her LinkedIn page. Here are some delicious recipes from the culinarymedicine.org and a podcast on culinary medicine to learn more! Learn more about your ad choices. Visit megaphone.fm/adchoices

Clinicians and patients are in a state of prognostic uncertainty when they are unsure about the future course of an illness. By embracing uncertainty while cultivating prognostic awareness, neurologists can serve the critical role of supporting patients and families through the living and dying process. In this episode, Casey Albin, MD, speaks with Robert G. Holloway, MD, MPH, FAAN, author of the article "Managing Prognostic Uncertainty in Neurologic Disease" in the Continuum® December 2025 Neuropalliative Care issue. Dr. Albin is a Continuum® Audio interviewer, associate editor of media engagement, and an assistant professor of neurology and neurosurgery at Emory University School of Medicine in Atlanta, Georgia. Dr. Holloway is the Edward and Alma Vollertsen Rykenboer Chair and a professor of neurology in the department of neurology at the University of Rochester School of Medicine and Dentistry in Rochester, New York. Additional Resources Read the article: Managing Prognostic Uncertainty in Neurologic Disease Subscribe to Continuum®: shop.lww.com/Continuum Earn CME (available only to AAN members): continpub.com/AudioCME Continuum® Aloud (verbatim audio-book style recordings of articles available only to Continuum® subscribers): continpub.com/Aloud More about the American Academy of Neurology: aan.com Social Media facebook.com/continuumcme @ContinuumAAN Host: @caseyalbin Full episode transcript available here Dr Jones: This is Dr Lyell Jones, Editor-in-Chief of Continuum. Thank you for listening to Continuum Audio. Be sure to visit the links in the episode notes for information about earning CME, subscribing to the journal, and exclusive access to interviews not featured on the podcast. Dr Albin: Hello, this is Dr Casey Albin. Today I'm interviewing Dr Bob Holloway about his article on managing prognostic uncertainty in neurologic disease, which appears in the December 2025 Continuum issue on neuropalliative care. Welcome to the podcast, and please introduce yourself to our audience. Dr Holloway: Hi, Casey, and thank you. Again, my name is Bob Holloway. I'm a clinician and neurologist up in Rochester, New York, and I've been doing both neurology and palliative care for many years. Dr Albin: Well, that's fantastic. And I really wanted to emphasize how much I really enjoyed reading this article. I know that we're going to get into some of the pearls that you offer, but I really want to tell the listeners, like, this is a great one to read because not only does it have sort of a philosophical take, but you also really provide some pragmatic tips of how we can help our patients manage this prognostic uncertainty. But maybe just tell us a little bit, what is prognostic uncertainty? Dr Holloway: Yes, thank you. Well, I think everyone has a sense of what prognostic uncertainty is. And it's just the uncertain futures that we as clinicians and our patients face. And I would just say that a way to summarize it is just, how do we manage the "not yet" of neurologic illness? Dr Albin: I love that. In neurologic illness, there is so much "not yet" and there are so many unknowns. And what I thought was really helpful about your article is you kind of give us three buckets in which we can think about the different types of uncertainty our patients are facing. What are those? Dr Holloway: This is, I think, an area that really is of interest to me, thinking about how to organize the prognostic "not yet" or that landscape. And one way I've tried to simplify it is to think about it as data-centered. And that's the world that we mostly live in as neurologists. That's the probability distributions. We also have kind of system-level uncertainties, and that's the uncertainties that our health system affords for our patients. And then we have, also, the patient-centered uncertainties and the uncertainties that those two prior categories cause for our patients. And that's a big uncertainty that we often don't address. Dr Albin: In reading the article, I was really struck by, we spend a lot of time thinking about data uncertainty. Can we get population-based research? Can we sort of look at prognostication scoring? I live in the ICU, and so we think a lot about these, like, scoring metrics and putting patients into buckets and helping us derive their care based on where their severity index is. And I'm sure that is true in many of the divisions of neurology. But what I did not really appreciate---and I thought you did a really fantastic job of kind of drawing our attention to---is there's a lot of system-centered uncertainty. Can you give us a little bit of examples, like, what is system-based uncertainty? Dr Holloway: I think system-level uncertainties just encompass the practical information gaps that may arise during our healthcare encounter. And a lot of, I think, the uncertainty that our patients face and families, they actually describe it as they feel captive by the uncertainty. And it's just the unknowns, not just what affords from the actual information about the disease and its prognosis in the future, but actually the level of the system, like, who's going to take care of them? How do you manage arranging for nurses to come into the home or all those practical-level uncertainties that the system provides that sometimes we don't do a good job of road-mapping for patients. Dr Albin: Absolutely. Because I feel like we have a little bit of a gap in that often as physicians. Like, the family asks, what will hospice at home look like? Well, you know, that's a question for case management. I think they'll come in and they'll tell you. But it strikes me that that's a real gap of my being able to walk patients through. Will they get home health care? Will they have transportation set up? Will there be a nurse who comes in to check? How often are they available? What's the cost going to be? All of these practical aspects of dealing with an illness that are beyond sort of our scope of knowledge, but probably have a huge practical impact to the patient. Dr Holloway: Without question, every encounter patients wonder about, that kind of future wish landscape that we- all our future-oriented desires and hopes. And so much of that is the practical aspects of our health system, which is often fragmented, kind of unknown, uncertain. And that's a huge source of uncertainty for our patients and families. And then that leads to many other uncertainties that we need to address. Dr Albin: Absolutely. I think another one that we, again, maybe don't spend quite as much time thinking about is this patient-level uncertainty. What's going on there? Dr Holloway: Yeah. So, I think patient-level uncertainty is that uncertainty that they experience when confronted with the two other types of uncertainty: the actual data-centered uncertainty and the system-level uncertainty. And that's that, kind of, very huge kind of uncertainty about what it means for them and their family and their future futures. And that's a source of huge stress and anxiety, and often frankly bordering on dread and fear for our patients and families. That actually gets into very levels of uncertainty that I would call maybe over even in the existential realm. Patient-level uncertainty in the actual existential questions or the fear and the dread or the kind of just unnerving aspect of it is actually even more important to patients than the scientific or data-centered uncertainty that we focus most of our attention on. Dr Albin: Yeah, I think this is, to me, was getting towards that, like, what does the patient care about and how are they coping with what is in many times a really dramatic shift in their life expectancy or morbidity expectations and this sort of radical renegotiation about what it means to have a neurologic illness? And how does that shift their thinking about who they are and their priorities in the world? Is that right? Dr Holloway: One thousand percent, and in fact, I will say---and I think is one of the main take home messages is that, you know, managing prognostic certainty is not an end in itself. It really is to help patients and families adaptively cope to their new and often harsh new reality, that we could help them adapt to their new normal. I think that is one of our main tasks as neurologists in our care teams is to help patients find and ultimately maybe achieve existential or spiritual or well-being even in their new health states. You know, that you certainly often see in the intensive care unit, but we often always see in the outpatient realm as well, and all our other diseases. Dr Albin: I think that's really hard to do. I think those conversations are incredibly difficult and trying to navigate where patients want to be, what would bring meaning, what would bring value. I think many of us struggle to have these pretty real and intense conversations with families about what really is important. And one of the things I really liked about this article is you kind of walk us through some steps that we as clinicians can take to get a little bit more comfortable. Maybe just walk us through, what are some of the things that you have found most helpful in trying to get families and patients to open up about what brings them meaning? How are they navigating this new, really uncertain time in their life? Dr Holloway: Yeah, so I do kind of have a ten-point recommendations of how to help cultivate a more integrated awareness of an uncertain future. I mean, I think the most important thing is actually just recognizing that embracing uncertainty as an amazingly remarkable cognitive tool. I mean, let's face it, uncertainty, when it happens with neurologic illness and disease, is often fearful. It's scary. It kind of changes our world. But on the flip side of it, it's a remarkable cognitive tool that actually can help us find new ways and new paths and new creativity. And I think we can use that kind of opposites to help our patients find new meaning in very difficult situations. So, thinking about uncertainty, kind of being courageous, leaning into it and recognizing that it does create anxieties and fear, but it also can kind of help create new solutions and new ideas to help people navigate. Dr Albin: I was hoping that maybe you could give us an example of, like, how would you do that? If a patient comes in and they're dealing with, you know, a new diagnosis and they're navigating this new uncertainty, what are some of the things that you ask to help them reframe that, to kind of take some of the good about that uncertainty? How do you navigate that? Dr Holloway: One of the other recommendations is actually just resetting the timeline and expectations for these conversations. That it shouldn't be expected that patients should accept their harsh new reality immediately, that it takes time in a trusted environment. And that there's this, like, oscillating nature of hopes and fears and dread, and you've just got to work with them over time. And with time, and once you understand who the patient and family are and understand where they find meaning and where they find, actually, joy in their life, or what actually brings them meaning, you can start recasting their futures into credible narratives in their kind of future landscape in ways that I think can help them enter into their new realities within the, you know, framework of disease management that you can offer them within your healthcare team or your healthcare system or wherever you are in the world and the available resources that you have to offer patients and families. Dr Albin: So, this sounds like a lot to me like active listening and really trying to get to know what is important to the family, what is important to the patient. And I guess probably just creating that space even in that busy clinical environment. Do I have that right? Dr Holloway: You can absolutely do that, right. You know, and honestly, active listening, we are challenged in our busy healthcare system to do this, but I think with the right listening skills and the appropriate ways of paying attention, you can definitely illuminate these possible, kind of future-oriented worlds for patients and help them navigate those new terrains with them. Frankly, I think that's a real new space for us in neurology. We don't think about and train how to create credible narratives for patients and families. We do it on the fly, but I think there's so much more work to do. How do you actually keep, you know, that best-case, worst-case, most likely credible narratives for patients that can help them adapt to their new realities and support them on their new journeys? Dr Albin: I love that best-case, worst-case, most likely case. I find that framework really helpful. But you talk in your article, it's not just about using that best case or worst case or most likely, but it's actually building some forecasting into that and having some real data to kind of support what you're saying. And there's a lot of growth towards actually becoming good as a medical forecaster. Can you describe a little bit, what did you mean by that? Dr Holloway: You're absolutely right. I think, actually, one of the skillsets of becoming and managing prognostic uncertainty is actually becoming a skilled medical forecaster. And it's a really tall order. So, we've got to be both good medical forecasters as well as helping patients adaptively cope to their new reality. But the good medical forecasting is actually now going more quantitative in thinking about the data that's available to help think about the important outcomes for patients and families and then predicting what their probabilities are so you can shape those futures around. So, yes, we do have to have an open mindset. We do have to actually look at the data that's available and actually think about, what are those long-term probabilities and outcomes? And we can be honest about those and even communicate them with families. But it's a really good skill set to have. Dr Albin: Yeah. This to me was a little bit about, how do you bring in the data knowledge that we try to get over time as we develop our expertise? You're developing not just a reliance on population-based data, but in my experience, I have seen this. And that sort of ability to kind of look at the patient in front of you, think about the big picture, but also a little bit about their unique medical comorbidities or prior life experiences. So, some of that database knowledge, and then bringing in and getting to know what is important to the patient. And so, sort of marrying that data-centric/patient-centric mindset. Dr Holloway: I love it. I guess the other way of saying that, too, is we need to think with precision, but communicate in narratives. And it's okay to gently put more precise estimates on our probability predictions with patients and families, what we think is the most likely case, best and worst case. Because patients and families want us to be more precise. We often shy away from it, but- so, it's okay to think in precisions, but we've got to put those in narratives in the most likely, best-, and worst-case scenarios. And don't be afraid if you think in terms of ninety percents, ten percents, fifty percents; most patients and families don't mind that. And what they're telling us is they actually want to hear that, if you are comfortable talking in those terms. Dr Albin: Yeah, absolutely. And giving a sense of the humility to say, like, this is my best guess based on medical data and my experience, I would say, but again, none of us have a crystal ball. And I do think families, as long as you're sort of couching your expectations into the sort of imperfect, but I'm doing my best, really appreciate that. Dr Holloway: They totally do all the time. Just say, I simply don't know for certain, but these are my best estimates. That's a good way of just phrasing that. Dr Albin: Yeah. So powerful. I don't know for certain. And then I wanted to just kind of close out, because there's this one term that you use that I thought was so interesting. And I wanted you to kind of tell our listeners a little bit about what you mean here, which is that, when you're actively open-minded, you're using this, quote, "dragonfly eyes." What do you mean by that? Dr Holloway: So, the dragonfly eyes, as you know, they can look at three sixty around them and they just, they move in all directions. Being actively open minded, I guess the biggest example I would say is, I don't like the term prognostic discordance, which means that there's a difference of subjective estimates of prognosis between patients and families. Being openly minded is actually embracing the potential information that the family has about prognosis and incorporating that into your estimates. So, I wouldn't say it's discordances, per se; I think being really actively open-minded is taking that all in and utilizing that as, you know what, they know more than you do about the patient and their loved ones, and they may have insights that can inform your best estimates of prognosis. So, the true dragonfly prognosticator actually is one who embraces and doesn't consider it discord, but considers it kind of new, useful information that I just need to weigh in so I can help the family in my best professional way in terms of developing a prognosis, whatever the condition may be. Dr Albin: I can imagine this is just so challenging and something that takes a long time to sort of perfect all of this. I think you say right below that, you need a growth mindset to do this because it is hard, and it's going to take an active participation and an active desire to get better at these conversations with our families. Dr Holloway: One thousand percent. You are so right that it takes time, effort, and not feeling like you're being challenged, but that actually you are including them in your entire body of knowledge, that you're just- it's part of all you're collecting. And even, I was on service last week, and I talked to residents and students about that very issue. It's like take their prognosis. And someone who came in, we thought CJB, very sad, tragic case, but we were thinking about what the future may look like and how do we actually work with the family who had very what we thought was unrealistic expectations. I said, well, no, this is not discordance. This is just useful information that we can take understand where they're coming from and incorporate that into the ways we want to build relationships, build trust, and over time we'll get to a point where we hopefully can work with them and have them have that fully integrated awareness of their future. Dr Albin: Yeah, that's beautiful. It really is this ongoing negotiation that really requires so much listening, understanding, and then obviously information and expertise about the data that we're presenting and the likelihood outcome, recognizing that there's a lot of uncertainty in all of this. Which, you know, again, this is kind of a 360 talk. At every level there is uncertainty, and that's what makes it so hard. Dr Holloway: Yeah, you're absolutely right. And actually, even in the article I kind of used the term radical uncertainty as that, no matter how resolvable all this uncertainty is, there will always still remain that radical element of our existence which we have to actually incorporate and be prepared for. And actually, not only of ourselves, but actually for patients and families and helping manage that. Using narratives and credible narratives and kind of ranges of possibilities is the best way to do that in a personalized way. Dr Albin: Well, this has been a fantastic conversation, and I know that we are running a bit short on time. So, as we wrap up and you think about this topic, are there any key take-home messages that you hope our listeners will walk away with? Dr Holloway: I think one main emphasis is that despite all the successes we feel we have in neurology, is that we all have to recognize that prognostic uncertainty is just going to increase in the future. But this is going to be for several reasons. One is that, just, the illness uncertainty of all of our great therapies are just going to be creating more uncertainty for the future. And precision medicine is paradoxical, and that actually it creates more uncertainty. So, I think we need to be prepared that we have to manage prognostic uncertainty better, because it's definitely going to increase. And two, it's what I said earlier, is that actually managing prognostic uncertainty is not an end to itself. It's actually helping patients and families adapt to their new and sometimes harsh new reality and actually help them to ultimately get to a place where maybe either their condition is neither dreaded, but actually they can accept it as their new reality and actually achieve some sort of existential well-being and existential health. I think that we have a lot more to emphasize in this area. And for far too long, we've focused on the certainty aspect of our field and not enough on the uncertainty in the world of medicine to help our patients and families. Dr Albin: And gosh, isn't there just so much uncertainty? And I think this has been beautiful. So, thank you again for coming and sharing your expertise. Dr Holloway: Thank you very much. It's been a pleasure. Dr Albin: For all of our listeners out there, this is a truly fantastic article, and I would just like to direct you to going to read the cases because not only do the cases offer a little bit of practical advice, but there's one that's actually sort of a philosophical discussion about, what does it mean to be alive and confront death? There's some beautiful artwork that's featured as well. So this is just a really unique article, and I'm excited for our listeners to have a chance to check it out. So again, today I've been interviewing Dr Bob Holloway about his article on managing prognostic uncertainty in neurologic disease, which appears in the December 2025 Continuum issue on neuropalliative care. Be sure to check out Continuum Audio episodes from this and other issues. Dr Monteith: This is Dr Teshamae Monteith, Associate Editor of Continuum Audio. If you've enjoyed this episode, you'll love the journal, which is full of in-depth and clinically relevant information important for neurology practitioners. Use the link in the episode notes to learn more and subscribe. AAN members, you can get CME for listening to this interview by completing the evaluation at continpub.com/audioCME. Thank you for listening to Continuum Audio.

ALBINÃO e GORILÃO são podcasters, RICARDINHO ACF é engenheiro mecânico e TIAGO TCAR é empresário. Eles vão bater um papo sobre tudo e sobre nada ao mesmo tempo. O Vilela teve que voltar das férias pra fazer esse episódio e provavelmente vai dormir o tempo todo.

When we talk about it, it makes you want to smile, but at the same time your eyes can fill with tears. And, speaking about saudade, I have a lot. Sunday is a saudade called Minas Gerais. Of the dreams I dreamed, of others that I didn't even allow myself to dream. In any corner of the world, saudade follows me, but especially in autumn. This sensation of things lost, past and future, grips me in the present. Sometimes it flows through my fingers, run over by the rush of everyday life. Saudade is what proves to us that we love, that we lived moments that were worthwhile, and that we have stories that deserve to be remembered. It's what connects us with what we were and who we were. Sunday is a day to remember everything you had, have and could have had. It's a time to be grateful, despite anything else. To me, this mix conveys a feeling not only of nostalgia but also the alchemy of saudade into a deep moment of rest and introspection. Watch the sun's rays come in through the window and smell the lush birth of a new day. I hope this selection brings warmth and spurs energy for your day. Words by @albindj Tracklist: U.e. - Froggy Explorer (28912, 2025) Ross Alexander - Fresh Ice Cream (Sucata Tapes, 2017) Stone - Achey (3 X L, 2025) Black Sabbath - Planet Caravan (Vertigo Records, 1970) Lars Barkuhn - Massai (Utopia Records, 2017) Ezra Feinberg - Soft Power ft. David Lackner (Tonal Union, 2024) Deux Filles - The Letter (Humbug, 1993) Joanne Robertson and Oliver Coates - Gown (AD 93, 2025) Unchained - Largo (A Colourful Storm, 2024) Purelink - First Iota ft. Angelina Nonaj (Peak Oil, 2025) Ark Noir - Anthocyanin (Molten Moods, 2023) Milton Nascimento e Jobim Trio - Dias Azuis (Blue Note, 2008) Skeleten - E Tusk (Self Release, 2025) Robert Rich - Whispers Of Eden (Hearts Of Space, 1994) Ludvig Cimbrelius - A Summer Yet To Come (Stereoscenic Records, 2024) LAVURN - Kill +1 (Self Release, 2025) Officer John - Handle (Wah Wah Wino, 2025) Skeleten - World Facing (Self Release, 2025) Sir Was - In The Midst (City Slang, 2017) conforter2 - How To Arrive (Nous'klaer Audio, 2023) Qur'an Shaheed - Dreams (Leaving Records, 2025) Herbert & Momoko - Need To Run (Accidental Records, 2025) Tom Skinner - The Maxim feat. Meshell Ndegeocello (International Anthem, 2025) Follow us on social media: @itsdelayed linktr.ee/delayed www.delayed.nyc www.facebook.com/itsdelayed www.instagram.com/_____delayed www.youtube.com/@_____delayed Contact us: info@delayed.nyc

Tisdag! Albin har viktigare saker för sig, men kakorna är inte mindre brända för det. Det blir dejting, fyrverkerier och äldrevård.Har du ett skvaller som fler borde få höra? Maila det till kafferepetpod@gmail.comMissa inte vår månatliga systerpodd Cigarrummet. Bli prenumerant på www.underproduktion.se/cigarrummet2:45 - Dålig dejt i Surte7:40 - Kaninen och raketen 9:40 - Det är Karin Hosted on Acast. See acast.com/privacy for more information.

durée : 01:29:10 - Cabaret 42e Rue : Laurent Laffite et la troupe de " La Cage Aux Folles " - par : Laurent Valière - Laurent Lafitte incarnera Albin et Zaza, rôle créé par Michel Serrault, dans l'adaptation française de "La Cage aux Folles" au théâtre du Châtelet en décembre, mise en scène par Olivier Py. Aux côtés de la troupe, il nous présente en avant première une sélection d'extraits en version acoustique. - réalisé par : Céline Parfenoff Vous aimez ce podcast ? Pour écouter tous les autres épisodes sans limite, rendez-vous sur Radio France.

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EPISODE 235 Charlotte Head Coach Tim Albin previews the Charlotte-ECU game on Saturday by Pirate Radio 92.7FM Greenville

Dans la sélection musicale de Brice Albin : Pepe Oleka, Nikanor, Fanicko, First King feat Fanicko, OPA, OPA feat T.Gang, Vano Baby, Bobo Wé, Axel Merryl et Credo. Pour visionner les clips, cliquez sur les titres des chansons :  Pepe Oleka - Sêbla koko Nikanor - Veux-tu m'épouser ? Fanicko - Origine First King feat Fanicko - Jago life OPA - Che Che Che OPA feat T.Gang le technicien - Pause Vano Baby - Fitè Bobo Wé - Mea culpa Axel Merryl feat Mia Guisse et Bass Thioung - Titulaire Credo - Dudedji Retrouvez la playlist officielle de RFI Musique.

While genetic testing has replaced muscle biopsy in the diagnosis of many genetic myopathies, clinical assessment and the integration of clinical and laboratory findings remain key elements for the diagnosis and treatment of muscle diseases. In this episode, Casey Albin, MD, speaks with Margherita Milone, MD, PhD, FAAN, FANA, author of the article “A Pattern Recognition Approach to Myopathy” in the Continuum® October 2025 Muscle and Neuromuscular Junction Disorders issue. Dr. Albin is a Continuum® Audio interviewer, associate editor of media engagement, and an assistant professor of neurology and neurosurgery at Emory University School of Medicine in Atlanta, Georgia. Dr. Milone is a professor of neurology and the director of the Muscle Pathology Laboratory at Mayo Clinic College of Medicine and Science in Rochester, Minnesota. Additional Resources Read the article: A Pattern Recognition Approach to Myopathy Subscribe to Continuum®: shop.lww.com/Continuum Earn CME (available only to AAN members): continpub.com/AudioCME Continuum® Aloud (verbatim audio-book style recordings of articles available only to Continuum® subscribers): continpub.com/Aloud More about the American Academy of Neurology: aan.com Social Media facebook.com/continuumcme @ContinuumAAN Host: @caseyalbin Full episode transcript available here Dr Jones: This is Dr Lyell Jones, Editor-in-Chief of Continuum. Thank you for listening to Continuum Audio. Be sure to visit the links in the episode notes for information about earning CME, subscribing to the journal, and exclusive access to interviews not featured on the podcast. Dr Albin: Hello, this is Dr Casey Albin. Today I'm interviewing Dr Margherita Milone on her article on a pattern recognition approach to myopathy, which appears in the October 2025 Continuum issue on muscle and neuromuscular junction disorders. Welcome to the podcast, Dr Milone. Thank you so much for joining us. I'll start off by having you introduce yourself to our listeners. Dr Milone: Hello Casey, thank you so much for this interview and for bringing the attention to the article on muscle diseases. So, I'm Margherita Milone. I'm one of the neuromuscular neurologists at Mayo Clinic in Rochester. I have been interested in muscle disorders since I was a neurology resident many years ago. Muscle diseases are the focus of my clinical practice and research interest. Dr Albin: Wonderful. Thank you so much. When I think about myopathies, I generally tend to think of three large buckets: the genetic myopathy, the inflammatory myopathies, and then the necrotizing myopathies. Is that a reasonable approach to conceptualizing these myopathies? Dr Milone: Yeah, the ideology of the myopathies can be quite broad. And yes, we have a large group of genetic muscle diseases, which are the most common. And then we have immune-mediated muscle diseases, which include inflammatory myopathies as well as some form of necrotizing myopathies. Then we have some metabolic myopathies, which could be acquired or could be genetic. And then there are muscle diseases that are due to toxins as well as to infection. Dr Albin: Wow. So, lots of different etiologies. And that really struck me about your article, is that these can present in really heterogeneous ways, and some of them don't really read the rule book. So, we have to have a really high level of suspicion, for someone who's coming in with weakness, to remember to think about a myopathy. One of the things that I like to do is try to take us through a little bit of a case to sort of walk us through how you would approach if someone comes in. So, let's say you get, you know, a forty-year-old woman, and she's presenting with several months of progressive weakness. And she says that even recently she's noted just a little bit of difficulty swallowing. It feels to her like things are getting stuck. What are some of the things when you are approaching the history that would help you tease this to a myopathy instead of so many other things that can cause a patient to be weak? Dr Milone: Yes. So, as you mentioned, people who have a muscle disease have the muscle weakness often, but the muscle weakness is not just specific for a muscle disease. Because you can have a mass weakness in somebody who has a neurogenic paralysis. The problem with diagnosis of muscle diseases is that patients with these disorders have a limited number of symptom and sign that does not match the large heterogeneity of the etiology. So, in someone who has weakness, that weakness could represent a muscle disease, could represent an anterior horn cell disease, could represent a defect of neuromuscular junction. The clinical history of weakness is not sufficient by itself to make you think about a muscle disease. You have to keep that in the differential diagnosis. But your examination will help in corroborating your suspicion of a muscle disease. Let's say if you have a patient, the patient that you described, with six months' history of progressive weakness, dysphagia, and that patient has normal reflexes, and the patient has no clinical evidence for muscle fatigability and no sensory loss, then the probability that that patient has a myopathy increases. Dr Albin: Ah, that's really helpful. I'm hearing a lot of it is actually the lack of other findings. In some ways it's asking, you know, have you experienced numbness and tingling? And if not, that's sort of eliminating that this might not be a neuropathy problem. And then again, that fatigability- obviously fatigability is not specific to a neuromuscular junction, but knowing that is a hallmark of myasthenia, the most common of neuromuscular disorders. Getting that off the table helps you say, okay, well, it's not a neuromuscular junction problem, perhaps. Now we have to think more about, is this a muscle problem itself? Are there any patterns that the patients describe? I have difficulty getting up from a chair, or I have difficulty brushing my hair. When I think of myopathies, I historically have thought of, sort of, more proximal weakness. Is that always true, or not so much? Dr Milone: Yeah. So, there are muscle diseases that involve predominantly proximal weakness. For example, the patient you mentioned earlier could have, for example, an autoimmune muscle disease, a necrotizing autoimmune myopathy; could have, perhaps, dermatomyositis if there are skin changes. But a patient with muscle disease can also present with a different pattern of weakness. So, myopathies can lead to this weakness, and foot drop myopathies can cause- can manifest with the weakness of the calf muscles. So, you may have a patient presenting to the clinic who has no the inability to stand on tiptoes, or you may have a patient who has just facial weakness, who has noted the difficulty sealing their lips on the glasses when they drink and experiencing some drooling in that setting, plus some hand weakness. So, the muscle involved in muscle diseases can vary depending on the underlying cause of the muscle disease. Dr Albin: That's really helpful. So, it really is really keeping an open mind and looking for some supporting features, whether it's bulbar involvement, extraocular eye muscle involvement; looking, you know, is it proximal, is it distal? And then remembering that any of those patterns can also be a muscle problem, even if sometimes we think of distal being more neuropathy and proximal myopathy. Really, there's a host of ranges for this. I really took that away from your article. This is, unfortunately, not just a neat way to box these. We really have to have that broad differential. Let me ask another question about your history. How often do you find that patients complain of, sort of, muscular cramping or muscle pain? And does that help you in terms of deciding what type of myopathy they may have? Dr Milone: Many patients with muscle disease have muscle pain. The muscle pain could signal a presence of inflammation in skeletal muscle, could be the result of overuse from a muscle that is not functioning normally. People who have myotonia experience muscle stiffness and muscle pain. Patients who have a metabolic myopathy usually have exercise-induced muscle pain. But, as we know, muscle pain is also very nonspecific, so we have to try to find out from the patient in what setting the pain specifically occurs. Dr Albin: That's really helpful. So, it's asking a little bit more details about the type of cramping that they have, the type of pain they may be experiencing, to help you refine that differential. Similarly, one of the things that I historically have always associated with myopathies is an elevation in the CK, or the creatinine kinase. How sensitive and specific is that, and how do you as the expert sort of take into account, you know, what their CK may be? Dr Milone: So, this is a very good point. And the elevation of creatine kinase can provide a clue that the patient has a muscle disease, but it is nonspecific for muscle disease because we know that elevation of creatine kinase can occur in the setting of a neurogenic process. For example, we can see elevation of the creatine kinase in patients who have ALS or in patients who have spinal muscular atrophy. And in these patients---for example, those with spinal muscular atrophy---the CK elevation can be also of significantly elevated up to a couple of thousand. Conversely, we can have muscle diseases where the CK elevation does not occur. Examples of these are some genetic muscle disease, but also some acquired muscle diseases. If we think of, for example, cases where inflammation in the muscle occurs in between muscle fibers, more in the interstitium of the muscle, that disease may not lead to significant elevation of the CK. Dr Albin: That's super helpful. So, I'm hearing you say CK may be helpful, but it's neither completely sensitive nor completely specific when we're thinking about myopathic disorders. Dr Milone: You are correct. Dr Albin: Great. So, coming back to our patients, you know, she says that she has this dysphasia. How do bulbar involvement or extraocular eye movement involvement, how do those help narrow your differential? And what sort of disorders are you thinking of for patients who may have that bulbar or extraocular muscle involvement? Dr Milone: Regarding dysphagia, that can occur in the setting of acquired myopathies relatively frequent; for example, in inclusion body myositis or in other forms of inflammatory myopathy. Your patient, I believe, was in their forties, so it's a little bit too young for inclusion body myositis. Involvement of the extraocular muscles is usually much more common in genetic muscle diseases and much less frequent in hereditary muscle disease. So, if there is involvement of the extraocular muscles, and if there is a dysphagia, and if there is a proximal weakness, you may think about oculopharyngeal muscular dystrophy, for example. But obviously, in a patient who has only six months of history, we have to pay attention of the degree of weakness the patient has developed since the symptom onset. Because if the degree of weakness is mild, yes, it could still be a genetic or could be an acquired disease. But if we have a patient who, in six months, from being normal became unable to climb stairs, then we worry much more about an acquired muscle disease. Dr Albin: That's really helpful. So, the time force of this is really important. And when you're trying to think about, do I put this in sort of a hereditary form of muscle disease, thinking more of an indolent core, something that's going to be slowly progressive versus one of those inflammatory or necrotizing pathologies, that's going to be a much more quick onset, rapidly progressive, Do I have that right? Dr Milone: In general, the statement is correct. They tend, acquired muscle disease, to have a faster course compared to a muscular dystrophy. But there are exceptions. There have been patients with immune mediated necrotizing myopathy who have been misdiagnosed as having limb-girdle muscular dystrophy just because the disease has been very slowly progressive, and vice versa. There may be some genetic muscle diseases that can present in a relatively fast way. And one of these is a lipid storage myopathy, where some patients may develop subacutely weakness, dysphagia, and even respiratory difficulties. Dr Albin: Again, I'm hearing you say that we really have to have an open mind that myopathies can present in a whole bunch of different ways with a bunch of different phenotypes. And so, keeping that in mind, once you suspect someone has a myopathy, looking at the testing from the EMG perspective and then maybe laboratory testing, how do you use that information to guide your work up? Dr Milone: The EMG has a crucial role in the diagnosis of muscle diseases. Because, as we said earlier, weakness could be the result of muscle disease or other form of neuromuscular disease. If the EMG study will show evidence of muscle disease supporting your diagnostic hypothesis, now you have to decide, is this an acquired muscle disease or is this a genetic muscle disease? If you think that, based on clinical history of, perhaps, subacute pores, it is more likely that the patient has an acquired muscle disease, then I would request a muscle biopsy. The muscle biopsy will look for structural abnormalities that could help in narrowing down the type of muscle disease that the patient has. Dr Albin: That's really helpful. When we're sending people to get muscle biopsies, are there any tips that you would give the listeners in terms of what site to biopsy or what site, maybe, not to biopsy? Dr Milone: This is a very important point. A muscle biopsy has the highest diagnostic yield if it's done in a muscle that is weak. And because muscle diseases can result in proximal or distal weakness, if your patient has distal weakness, you should really biopsy a distal muscle. However, we do not wish to biopsy a muscle that is too weak, because otherwise the biopsy sample will result just in fibrous and fatty connected tissue. So, we want to biopsy a muscle that has mild to moderate weakness. Dr Albin: Great. So, a little Goldilocks phenomenon: has to be some weak, but not too weak. You got to get just the right feature there. I love that. That's a really good pearl for our listeners to take. What about on the flip side? Let's say you don't think it's an acquired a muscular disease. How are you handling testing in that situation? Dr Milone: If you think the patient has a genetic muscle disease, you pay a lot of attention to the distribution of the weakness. Ask yourself, what is the best pattern that represent the patient's weakness? So, if I have a patient who has facial weakness, dysphagia, muscle cramping, and then on examination represent myotonia, then at that point we can go straight to a genetic test for myotonic dystrophy type one. Dr Albin: That's super helpful. Dr Milone: So, you request directly that generic test and wait for the result. If positive, you will have proof that your diagnostic hypothesis was correct. Dr Albin: You're using the genetic testing to confirm your hypothesis, not just sending a whole panel of them. You're really informing that testing based on the patient's pattern of weakness and the exam findings, and sometimes even the EMG findings as well. Is that correct? Dr Milone: You are correct, and ideally, yes. And this is true for certain muscle diseases. In addition to myotonic dystrophy type one, for example, if you have a patient who has fascial scapulohumeral muscular weakness, you can directly request a test for FSHD. So, the characterization of the clinical phenotype is crucial before selecting the genetic test for diagnosis. Dr Albin: Wonderful. Dr Milone: However, this is not always possible, because you may have a patient who has just a limb-girdle weakness, and the limb-girdle weakness can be limb-girdle muscular dystrophy. But we know that there are many, many types of limb-girdle muscular dystrophies. Therefore, the phenotype is not sufficient to request specific genetic tests for one specific form of a limb-girdle muscular dystrophy. And in those cases, more complex next-generation sequencing panels have a higher chance of providing the answer. Dr Albin: Got it, that makes sense. So, sometimes we're using a specific genetic test; sometimes, it is unfortunate that we just cannot narrow down to one disease that we might be looking for, and we may need a panel in that situation. Dr Milone: You are correct. Dr Albin: Fantastic. Well, as we wrap up, is there anything on the horizon for muscular disorders that you're really excited about? Dr Milone: Yes, there are a lot of exciting studies ongoing for gene therapy, gene editing. So, these studies are very promising for the treatment of genetic muscle disease, and I'm sure there will be therapists that will improve the patient's quality of life and the disease outcome. Dr Albin: It's really exciting. Well, thank you again. Today I've been interviewing Dr Margarita Malone on her article on a pattern recognition approach to myopathy, which appears in the October 2025 Continuum issue on muscle and neuromuscular junction disorders. Be sure to check out Continuum Audio episodes from this and other issues, and thank you to our listeners for joining us today. And thank you, Dr Milone. Dr Milone: Thank you, Casey. Very nice chatting with you about this. Dr Monteith: This is Dr Teshamae Monteith, Associate Editor of Continuum Audio. If you've enjoyed this episode, you'll love the journal, which is full of in-depth and clinically relevant information important for neurology practitioners. Use the link in the episode notes to learn more and subscribe. AAN members, you can get CME for listening to this interview by completing the evaluation at continpub.com/audioCME. Thank you for listening to Continuum Audio.

In this episode, host Bill Calkins is joined by industry strategist and co-founder of A24 Consulting, Clint Albin, to discuss the artificial intelligence (AI) in the greenhouse and garden center industry. Bill and Clint explore the challenges faced by green industry businesses, including seasonal fluctuations and changing consumer behaviors and how AI can provide solutions to enhance customer engagement and streamline operations—what Clint refers to as “the front door and the overhead door”. The conversation emphasizes the importance of integrating AI thoughtfully and creatively into existing processes, the need for immediate customer feedback and some potential risks associated with AI implementation. Clint shares insights on future Green Profit article and podcast topics related to procurement and local marketing strategies, highlighting the significance of innovation in the horticulture sector. Some key takeaways from this episode: AI can empower businesses of all shapes and sizes. Our industry faces challenges due to seasonal business cycles. Customer visits to garden centers need to be increased. Immediate customer feedback is crucial for improvement. AI should not be applied to broken systems. The essence of abundance in AI can save time or make money. A policy on AI usage is necessary for each business. Understanding customer needs is always a key to success. This podcast supplements an article series in Green Profit magazine. Why You Need AI, No Matter Your Size (September 2025)

Join Nick Lamagna on The A Game Podcast with our guest Nick Albin, aka "Chewy," one of the most well known Brazilian Jiu Jitsu Black Belts and entrepreneurs on the internet today!  He is an entrepreneur, business owner, podcast host and coach fighting out of Louisville, Kentucky!  After a traumatic experience where he was jumped in high school, he lacked self confidence and a sense of safety and self worth.  He was eventually brought back out of his shell and gained his confidence back through wrestling, weight lifting and martial arts eventually earning a black belt in Brazilian Jiu Jitsu in 2011. This self proclaimed meathead at heart has an extensive background in martial arts, health, nutrition and fitness.  He has a gift for explaining things in an entertaining and relatable way which has caught on like wild fire where he has earned a blackbelt in branding business and marketing.  He continually finds ways to grow his academy and podcast sharing his love of Brazilian jiu jitsu, health and fitness with the world through his academy, Derby City Mixed Martial Arts and his wildly popular Youtube Channel and social media, where athletes and business owners can relate to the parallels of the stress of humanity and he is connecting the bridges of the brains of the civilian and the combat sport competitor to show us that we're all the same and can help each other do better He also has a popular tournament, The Chewjitsu Open he puts on and is gaining a lot of traction in the competition circles.   You know him through his Chewjitsu brand,The Chewjitsu Podcast and his successful Chew Crew Newsletter, welcome to the A Game Podcast, BJJ Royalty Nick Albin! Topics for this episode include: ✅ An important question you must answer before you go into business ✅ The answer to successful branding that no one wants to hear ✅ How to deal with fear and anxiety in life and business ✅ Learn the superpower to embrace the things you don't enjoy ✅ What to look for when you're trying to find a great mentor + more! Check the show notes to connect with all things Chewy!   Connect with Nick "Chewy" Albin: www.chewjitsu.net Nick Albin on Facebook Nick Albin on Instagram Nick Albin on Twitter Nick Albin on LinkedIn Nick Albin on TikTok Nick Albin on Youtube Free Focused BJJ Ebook Subscribe to the Chew Crew Newsletter!   Connect with ChewJitsu Podcast: ChewJitsu Podcast Chewjitsu Podcast on Facebook Chewjitsu Podcast on Instagram Chewjitsu Podcast on Threads Chewjitsu Podcast on Youtube   Connect with Derby City: Derby City Mixed Martial Arts Derby City Mixed Martial Arts on Facebook Derby City MMA on Instagram Derby City MMA on Threads Derby City Mixed Martial Arts on Youtube     Connect with other Chewy Jitsu Open Tournament: The Chewjitsu Open On Facebook Chewjitsu Open on Instagram Chewjistu Open on Threads --- Connect with Nick Lamagna www.nicknicknick.com Text Nick (516)540-5733 Connect on ALL Social Media and Podcast Platforms Here FREE Checklist on how to bring more value to your buyers  

Our friend Albin Sadar joins us to discuss his recent article "Some People Are Still Oblivious to the Obvious".The article criticizes modern gender norms as rejecting self-evident truths and urges Christians to actively defend traditional values.See omnystudio.com/listener for privacy information.

Albin shares a 4th of July Fun Facts Friday!See omnystudio.com/listener for privacy information.

Albin joins us again this week for a Fun Facts Friday specialSee omnystudio.com/listener for privacy information.

Eric is interviews by Albin about his book Fish out of Water See omnystudio.com/listener for privacy information.

Albin Sadar Recaps the High Seas Hijinks on the Greek Cruise with EricSee omnystudio.com/listener for privacy information.

Albin Sadar returns with his latest articles including "Silence isn’t peace — it’s just surrender in slow motion." https://www.theblaze.com/columns/opinion/silence-isnt-peace-its-just-surrender-in-slow-motionSee omnystudio.com/listener for privacy information.