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Needle-Free Peptides, US Manufacturing, BPC-157, Thymosin Alpha-1, GLP-1s, Microneedle Patches, and How to Avoid Contaminated Peptides Peptides are one of the most powerful tools in biohacking and anti-aging medicine, and until now, most people couldn't access them safely, legally, or without a needle. This episode changes that. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR -Go to Aminoinnovations.com and use “asprey20” for a discount through the next 7 days Host Dave Asprey sits down with Justin Kirkland, a longevity medicine expert with over 30 years in drug development and pharmaceutical innovation. Kirkland holds multiple drug synthesis and formulation patents, has founded multiple pharmaceutical companies, and is one of the few people in the world manufacturing peptides entirely on US soil, controlling every step of the synthesis process from raw amino acids to finished product. If you want to understand what is really inside your peptides and why it matters for your longevity and human performance, he is the person to listen to. Dave and Justin go deep on why most peptides on the gray market contain dangerous residual compounds that can spike liver enzymes and cause real harm, why Chinese-sourced APIs are not always what they claim to be, and how a new generation of needle-free delivery systems including microneedle patches and auto-injectors is making peptide therapy accessible to anyone serious about longevity and human performance. They also cover how AI and functional medicine are converging to make peptide protocols personalized based on genetics and microbiome status, why the thymus gland is one of the most overlooked anti-aging targets in the body, and what the suppression of peptide research reveals about who really controls your access to health tools. You Will Learn: Why many gray market peptides contain toxic residual acids that damage the liver and how to identify clean products How microneedle patches and auto-injectors are replacing traditional injections for peptide delivery Which peptides are most effective for longevity, immune system repair, and human performance including BPC-157, Thymosin Alpha-1, and growth hormone secretagogues Why your genetics and gut microbiome determine whether a peptide will work for you at all How the thymus gland controls your immune system and why it disappears by your mid-20s What the suppression of peptide research tells you about Big Pharma's control over your supplement and nootropics access Why US-manufactured peptides represent a new standard for safety and quality in biohacking How AI is transforming personalized peptide protocols in functional medicine Which peptides are overhyped and which ones actually move the needle on anti-aging and recovery How to store, mix, and dose peptides correctly to avoid the mistakes most people using them are making right now Thank you to our sponsors! - Danger Coffee | Grab yours at DangerCoffee.comand use code DAVEPOD at checkout for 15% off. - The One Device | Use code DAVE for $10 off at theonedevice.com/dave - Fatty15 is on a mission to support Healthy Aging for All, including all ages and stages of life. You can get an additional 15% off their 90-day subscription Starter Kit by going to fatty15.com DAVE and using code DAVE at checkout. - ENERGYbits | If you want a simpler, smarter way to support your body… this is it. Head to ENERGYbits.com and use code ASPREY for 20% off your order. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Justin Kirkland, peptides, needle-free peptides, microneedle patch, BPC-157, Thymosin Alpha-1, ipamorelin, CJC-1295, PT-141, KPV peptide, Dihexa, growth hormone secretagogue, peptide purity, TFA contamination, gray market peptides, US manufactured peptides, oral peptides, transdermal delivery, thymus gland, anti-aging, biohacking, longevity, functional medicine, peptide auto-injector, compounding pharmacy Resources: • Go to Aminoinnovations.com and use “asprey20” for a discount through the next 7 days • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Intro & Guest Welcome 01:55 – Censorship & Platform Bans 06:20 – Peptide Science & Bioavailability 07:20 – Delivery Methods 14:30 – Supply Chain & US Manufacturing 17:01 – Manufacturing Risks & Contamination 24:43 – Peptide Stacks 28:41 – Immune Peptides & Thymus 30:57 – Overhyped Peptides 41:00 – Alternative Delivery (Patches, Nasal, Rectal) 47:25 – Side Effects & Risk 50:30 – Mixing & Storage Tips 54:05 – Wrap-Up & Where to Buy See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
La creatina es el suplemento más vendido del mundo.Y hay una conversación que nadie en la industria quiere tener sobre ella y el cáncer.En este episodio Carlos Muñoz habla sin filtros con un experto en medicina de frontera sobre lo que realmente alarga la vida — y lo que te están vendiendo que no funciona.━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
Contacto: dr.vic@sunsetsocial.mxDr. Perez Galaz: https://www.instagram.com/drperezgalaz?igsh=MW50ZHA0MHR4cGYxaQ==¿Son los péptidos el secreto de la eterna juventud o una bomba de tiempo para tu salud?
Join the Loss crew tonight for a quick and dirty look at the brand new and old-new profiles for the upcoming Operation Mazebreaker release! Will OSS and CJC get the much needed love they deserve? Watch and find out! Thanks for Watching ! If you'd like to get some sweet Infinity Dice check out Baron of Dice! Use code "Loss" to get 5% off at checkout! https://baronofdice.com/?ref=LOSS Facebook: https://www.facebook.com/LossofLieutenant Patreon: https://www.patreon.com/lossoflieutenant Discord: https://discord.gg/MBG4hesQZt
Today we are talking about CJC 1295 and its potential benefits. Read the Full Episode Transcript: https://pepties.com/the-power-of-cjc-1295/ Related Links/Products Mentioned: Peptide Podcast Partners Page https://pepties.com/partners/ Buy Peptides online at BioLongevity Labs: Use our link and enter COUPON CODE: PEPTIDEPODCAST at checkout to receive 15% off your total order: https://go.biolongevitylabs.com/SH5C Momentous Supplements (we use Creatine, Vital Aminos, Whey Protein) https://crrnt.app/MOME/OqGQOxGA LMNT – More Salt, Not Less. https://elementallabs.refr.cc/default/u/johnjavit Thorne Supplements (we use Omega-3 with CoQ10, Red Yeast Rice, Zinc) https://get.aspr.app/SH1KvW Organifi Creatine and Shilajit Gummies http://rwrd.io/rlbkajm?c MitoZen (methylene blue for Cognitive Function, Anti-Aging, Mental Clarity) https://www.mitozen.com/ref/cnlwiztypt/ For skin and hair health (Copper Tripeptide-1) Visit Luminose by Entera for an exclusive offer for Peptide Podcast listeners! ** Promo code PEPTIDEPODCAST at checkout for 10% off an order or 10% off the first month of a subscribe-and-save. ** https://www.enteraskincare.com/?rfsn=8906839.f93c72 NAD+ Push Patch: https://www.pushpatch.com/
CJC-1295 is one of the more popular peptides that helps to release natural growth hormone. Others include Sermorelin and Tesamoralin. But can it replace synthetic growth hormone?https://i-prevailsupps.com/ discount code S&S10#johnlivia #anabolicacademy #seriousandsillinessbodybuilding #HGH #CJC_1295Support the show
Hosts: Ed Jones (Owner – Nutrition World) & Clint Powell A variety of topics all related to living a healthy life Presented by: Nutrition World www.nutritionw.com Broadcasting from the Nooga Dentistry Studio www.noogadentistry.com Production of: Whitfield Media Group www.vitalhealthradio.com Title: All About Peptides, & The Good, Bad & Ugly of GLP-1's [0:00:00] Ed's Restaurant Story & Healthy Eating Choices Ed's recurring bit: “Where did Ed eat this week?” Long‑time favorite restaurant Epicurean. Discussion of consistent healthy ordering and making good choices at long‑standing, family‑owned restaurants. [0:03:13] Building a Health “Team” & Ed's Top Learning Resources Tease of today's main topic: peptides with local expert Noel Lawson, NP. Ed stresses “team approach” to aging—no single practitioner has all the answers. Learners vs. non‑learners: why ongoing self‑education is critical for health. Ed's 4 favorite online resources: Mercola.com – more cutting‑edge, sometimes controversial content. DrJockers.com – accessible, visual education on ailments and nutrients. GreenMedInfo.com – indexed medical literature backing natural claims. Nutrition World Instagram – short, practical health “snippets”. Story: Nutrition World wins a surprise $10,000 award from Ancient Nutrition for #1 sales growth in the U.S., tied to belief in product quality. [0:10:38] Introducing Noel Lawson & “What Are Peptides?” Introduction of Noel Lawson, NP (Double Bridges Health & Wellness), now practicing on the Nutrition World campus. Noel's background: Transition from traditional medicine to functional medicine due to patient frustration, worsening chronic illness, and provider burnout. Goal: more prevention and root‑cause care. Orthopedic background led her to peptides. What is a peptide? Peptides are like the body's Morse code—specific chains of amino acids acting as signals. Under ~40 amino acids = peptide; longer chains = protein. Body breaks down dietary protein into amino acids and re‑assembles them into peptides as needed (e.g., for repair). As we age, the body produces fewer peptides, which is why we heal slower and are more prone to injury and inflammation. [0:19:26] Functional Medicine + Peptides: Approach, Expectations & Use Noel's approach: Combines functional medicine with peptides. Peptides only work well if the materials (sleep, nutrients, stress management, movement) are in place. Uses comprehensive labs to optimize baseline health first. Delivery & protocols: ~90% of peptides are injectable (tiny insulin‑type needle, usually daily). Some oral options exist Local injections near the injury area Expectations & timelines First 2–3 weeks: less inflammation, modest improvement in pain, sleep, and energy. 6–8 weeks: improved range of motion and strength. After 3 months: realistic minimum for true tissue change; peptides can't shortcut normal cell‑turnover timelines. [0:21:41] Specific Peptides & Treatment Logistics High‑demand musculoskeletal peptides: BPC‑157 and TB‑500: commonly used for tendons, ligaments, muscle and injury recovery. Growth hormone related peptides: Examples: samorelin, CJC, ipamorelin, tesamorelin. Stimulate the pituitary to release natural human growth hormone (HGH) rather than supplying exogenous HGH. Potential benefits: lean muscle mass, better body composition, cardiometabolic support. Monitored via IGF‑1 levels to avoid excess. PT‑141 for sexual health: Crosses the blood–brain barrier and activates pleasure/desire centers. Can cause nausea in some people; alternative forms (nasal spray, sublingual troche) may reduce side effects. How Noel works with patients: Website: doublebridgeswellness.com Contact form → email → optional free 20‑minute expectations call to see if there's a good fit. 1‑hour new patient visits, not rushed; she practices on the Nutrition World campus. [0:35:01] GLP‑1 Drugs (Ozempic, Trulicity, Mounjaro): Good, Bad & Ugly Case study: 65‑year‑old woman with pre‑existing gastroparesis put on Trulicity. Developed severe vomiting, dehydration, abdominal pain; was initially reassured to “get used to it.” Second dose led to life‑threatening pancreatitis, requiring hospitalization. Later prescribed Mounjaro by same clinic despite this history. The “Good” of GLP‑1s: In Curt's clinic, used selectively for: Poorly controlled diabetes (A1c > 10, average sugars in the 300s). Significant obesity. Can lower blood sugar and drive weight loss, by suppressing appetite The “Bad”: Common GI side effects (up to ~50% of users): Nausea, vomiting, constipation. Worsening gastroparesis (slow gut motility). Rapid weight loss often includes loss of muscle and bone, not just fat—hurts longevity and functional strength. Ozempic face: gaunt facial appearance from aggressive fat/muscle loss. Risk of hypoglycemia Visual issues, including increased macular degeneration risk. Psychiatric concerns: Emerging data on increased suicidal ideation, especially notable because trials excluded psychiatric patients. The “Ugly”: Pancreatitis, gallbladder problems. Thyroid tumors in some models. Possible cardiac atrophy. Massive growth in use: tens of millions prescribed, with many discontinuing within a year due to side effects or cost. Risk that people treat GLP‑1s as a “magic bullet” without nutrition or lifestyle change—and regain ~85% of lost weight after stopping. Curt's conclusion: GLP‑1s should be reserved for specific, high‑risk cases and paired with close coaching. For most people, there are safer, natural options. [0:50:12] “Nature's Ozempic,” Gut Health & Upcoming Events Ed and Curt on supporting GLP‑1 pathways naturally: Berberine – “nature's Ozempic” for blood sugar and metabolic support. Akkermansia (probiotic strain) – gut health, metabolic benefits, GLP‑1 stimulation. Butyrate – short‑chain fatty acid that: Supports gut lining / leaky gut repair. Improves colon health and may help increase GLP‑1. Ed reports best bowel function of his life using 2 caps/day. People who start GLP‑1s often increase supplement use, but tend to stop supplements when the drug stops. Coaching is needed so they maintain nutrition and supplementation after GLP‑1 discontinuation. Practical tips & announcements: Colonoscopies: clear protein drinks are now typically allowed on prep day—can help preserve muscle and stabilize blood sugar. Upcoming Lunch & Learn (online): Topic: “The Microbiome's Impact on Longevity”. Format: Instagram Live (@NutritionWorld), Tuesday, May 5 at 12:15 PM. Upcoming in‑person lecture at Nutrition World campus: Topic: “Taming the Yeast: Candida‑Reducing Strategies”. Thursday, May 21 at 5:30 PM. Registration via nutritionw.com → Events. Closing: Ed and Clint wrap up, reiterating their mission of clear, actionable health guidance and noting the show will be out on major podcast platforms. The post Radio Show / Podcast – May 3, 2026 first appeared on Vital Health Radio.
Peptides are everywhere right now, but are they the breakthrough they claim to be or just another wave of hype?In this episode of the Functional Longevity Podcast, Chris Borda cuts through the noise to explain what peptides actually are, how they work in the body, and the critical difference between FDA-approved therapies and the gray market options flooding the industry. He also breaks down what current research says about popular compounds like BPC 157 and CJC 1295.More importantly, you will walk away with a simple, practical framework to evaluate any supplement or therapy before you put it in your body. If you are over 40 and want to make smarter, more confident decisions about your health, recovery, and performance, this episode is a must-listen.#FunctionalLongevity #Over40Fitness #LongevityHealth #Peptides #RecoveryScience #HealthyAging #StrengthAfter40 #FitnessOver40 #Biohacking#SupplementTruth #EvidenceBasedFitness #MetabolicHealth #HormoneHealth #TrainForLife#MuscleAfter40 #LongevityLifestyle #OptimizeYourHealth#ChrisBorda #YESFitness #FarmingtonValleyFitness
In this solo episode, I'm sharing my personal experience with peptides, what they are, how I've used them, and why they've made such a big difference in the way I feel.I talk about GHK-Cu, BPC-157, and CJC-1295, what they are meant to support, and what I've noticed in my own body through recovery, sleep, training, and healing.This is not a medical deep dive, and it is definitely not advice from a doctor. It is a real conversation about what has helped me, what surprised me, and why I think peptides are worth understanding if you care about performance, recovery, and aging well.Highlights:(02:06) - What peptides actually are, and why they are not the same as GLP-1s(04:35) - My experience with GHK-Cu for skin, hair, and recovery(08:49) - Why BPC-157 impressed me so much for injury healing(13:12) - How CJC-1295 supports growth hormone, sleep, and recovery(14:56) - The changes I noticed in my body within the first couple of weeks(21:54) - The back pain story that made me a believer in peptidesFIT AMINOS: LINK AND CODE (NICOLES) https://fitaminos.com/ref/nicole.sciacca/ELLIEMD: LINK AND no code needed: https://elliemd.com/nicolesciaccaQualia Mind - click hereCoupon Code: SHOCKANDYALL (15% off any purchase)Visit Nicole's on demand fitness platform for live weekly classes and a recorded library of yoga, strength training, guided audio meditations and mobility (Kinstretch) classes, as well: https://www.sweatandstillness.comGrab Nicole's bestselling children's book and enter your email for A FREE GIFT: https://www.yolkedbook.comFind Nicole on Instagram:https://www.instagram.com/nicolesciacca/Tik Tok: https://www.tiktok.com/@thenicolesciaccaFacebook: https://www.facebook.com/nicolesciaccayoga/Youtube:https://www.youtube.com/channel/UC1X8PPWCQa2werd4unex1eAPractice yoga with Nicole in person in Santa Monica, CA at Aviator Nation Ride. Get the App to book in: https://apps.apple.com/us/app/aviator-nation-ride/id1610561929Book a discovery call or virtual assessment with Nicole here: https://www.calendly.com/nicolesciaccaThis Podcast is proudly produced by Wavemakers Audio
Most disciplined executives and entrepreneurs aren't struggling with fat loss because of effort or willpower. They're struggling because they're out of sequence—jumping straight to peptides, compounds, and advanced protocols before the three biological levers that actually drive fat loss are even stable.In this episode, Julian Hayes II breaks down the exact three mechanisms that determine whether your body gets lean and stays lean—and how to pull each one in the right direction before layering in anything advanced.You'll walk away understanding why fat loss is a sequencing problem, not a knowledge problem, and what it actually looks like to build a metabolic foundation that performs the way your business does. For executives and entrepreneurs operating in high-stakes environments, this episode connects biology directly to business performance.— Episode Chapter Big Ideas (timing may not be exact) —0:00 – Why disciplined high performers still don't look the part 1:57 – The three biological levers behind sustainable fat loss2:51 – About Julian and Executive Health3:26 – Who this conversation is actually for 4:49 – Lever 1: Nutrient Partitioning: where do your calories actually go?6:04 – The capital allocation analogy: investing in lean tissue vs. storing fat6:50 – The four factors that determine partitioning efficiency12:26 – Practical foundation: how to optimize partitioning before going advanced13:19 – Earning your carbs: the Charles Poliquin philosophy15:30 – GLP-1 receptor agonists and nutrient partitioning15:49 – Testosterone and hormonal optimization: Why hormones make everything go18:06 – Lever 2: Recovery Signaling: Where most high performers self-sabotage19:09 – What recovery signaling actually controls in a deficit19:33 – Cortisol21:02 – Growth hormone22:07 – Thyroid conversion: the T4 to T3 problem nobody talks about24:15 – HRV: your autonomic nervous system's engine light27:07 – Practical recovery: sleep timing and maximizing slow-wave GH pulses28:53 – Protein in a deficit: the primary defense against muscle loss29:39 – Electrolytes, magnesium, and why micronutrients matter more on GLPs32:51 – Advanced layer: CJC-1295 and Ipamorelin34:17 – Exogenous HGH: beyond bodybuilding34:54 – BPC-157 and TB-500: the gateway peptides for recovery35:58 – The 90/95 rule: foundation is the work, advanced tools are the amplifier36:34 – Lever 3: Appetite and Energy Regulation: the compliance lever37:22 – Why fat loss is a compliance problem, not a knowledge problem37:34 – Food noise is biological, not psychological38:51 – What poor appetite regulation actually costs executives40:24 – How aggressive deficits suppress testosterone41:15 – Performance as the feedback loop for energy regulation43:00 – Fiber, gut health, and natural GLP-1 secretion44:06 – Meal timing and circadian biology46:52 – Advanced layer: Semaglutide, Tirzepatide, and Retatrutide explained50:30 – Muscle loss, GI risk, and why lifestyle habits are the real variable51:24 – Genetics and fat loss52:47 – Low-dose Naltrexone54:19 – Thymosin Alpha-1 and emerging peptide research on energy regulation55:36 – Tying it all together: Foundation First, Amplification Second57:01 – The cost of skipping a sequence59:05 – The executive case for fat loss beyond aesthetics1:01:30 – How to work with Julian privately— Connect with Julian and Executive Health —LinkedIn — https://www.linkedin.com/in/julianhayesii/X — https://x.com/thejulianhayesReady to take your health, leadership, and performance to the next level? Book an exploratory call —https://www.executivehealth.io/contactWebsite — https://www.executivehealth.io/***DISCLAIMER: The information shared is not meant to treat or diagnose any condition. This is for educational, informational, and entertainment purposes. The content here is not intended to replace your relationship with your doctor and/or medical practitioner. Consult your provider before making any decisions.
Stop looking for the magic pill and start fixing the foundation that's actually killing your progress. Yale-trained neurovascular physiologist Dr. Dwayne Jackson returns to expose why your high-tech peptide stack and "science-based" training mean nothing if you haven't mastered the internal metrics of auto-regulation. From surviving stage four kidney failure to walking away from the Ivy League "iron curtain," Jackson breaks down what it actually takes to perform at an elite level—without destroying your health in the process. INSIDE THE EPISODE: The Auto-Regulation Blueprint Learn how to bridge the gap between perceived effort and physiological reality—and avoid the ego-lifting plateau. Peptide Truth Bombs A deep dive into BPC-157, CJC-1295, and why most "mitochondria activation" content is hype. The Kidney Crisis Dr. Jackson shares his transplant story and the hidden health markers strength athletes ignore. The Anabolic Rebound Why healthier bodies build more muscle—and how lowering your dose can improve your physique. Psychological Compartmentalization Using the gym to build resilience without turning it into an escape mechanism. MEET THE GUEST: Dr. Dwayne N. Jackson, PhD, is a Yale-trained medical scientist with over 30 years of experience in competitive bodybuilding and professional motocross. After retiring as a tenured professor, he now serves as the Nutrition Director at Pre-Script and consults with elite athletes facing complex health challenges. As a kidney transplant recipient, his work focuses on balancing high performance with long-term metabolic health and survival. SUPPORT THE SHOW: Become an elitefts channel member for early access and exclusive perks: ➡️ @eliteftsofficial FULL Crew Access: https://www.elitefts.com/join-the-crew Limited Edition Apparel: https://www.elitefts.com/shop/apparel/limited-edition.html Programs & More: https://www.elitefts.com/shop/dave-tate-s-table-talk-crew.html TYAO Application: https://www.elitefts.com/dave-tate-s-tyao-application BEST-SELLING ELITEFTS PRODUCTS: Pro Resistance Bands: https://www.elitefts.com/shop/bands.html Specialty Barbells: https://www.elitefts.com/shop/bars-weights/specialty-bars.html Wraps, Straps, Sleeves: https://www.elitefts.com/shop/power-gear.html SPONSORS: elitefts (Code: TABLE TALK – 10% OFF): https://www.elitefts.com/ Marek Health Labs (Code: TABLETALK – 10% OFF): https://marekhealth.com/tabletalk LMNT (Free Sample Pack): http://www.drinklmnt.com/tabletalk Massenomics: https://www.massenomics.com/ MASS Research Review (Code: ELITEFTS20 – 20% OFF): https://massresearchreview.com/ RP Hypertrophy App (Code: TABLE TALK – 10% OFF): https://rpstrength.com/pages/hypertrophy-app
In March 2026, the largest gray-market peptide vendor in the U.S. went dark overnight. No refunds, and a wave of uncertainty about what these products actually are, how they're sourced, and whether they're worth the risk.In this episode, Jeff works through what peptides actually are, where the science holds up and where it doesn't, and what the gray-market collapse means for anyone paying attention to this space. Topics covered: BPC-157, CJC-1295, ipamorelin, and TB-500: what the research actually shows Why are oral peptide capsules mostly expensive amino acids The sourcing landscape: FDA-approved, compounding pharmacies, and gray market Who peptide therapy may be right for, and who should wait Free, evidence-backed alternatives for GH optimization and injury recovery This episode is for anyone who's been curious about peptide injections and wants the honest answer, not the Joe Rogan version. This episode was made possible by: Sunlighten: Visit sunlighten.com/commune Up to 2,100 off saunas and $50 off Red Light Products with code “COMMUNE” Bon Charge: Get 15% off when you order at boncharge.com and use promo code COMMUNE Stemregen: Get 20% off your first order at stemregen.co/commune with the code COMMUNEPOD Vivobarefoot: Try Vivobarefoot risk-free with a 100-day return guarantee, and get 15% off your order at vivobarefoot.com/commune. Beyond Biohacking: Save $400 on any ticket with code COMMUNE400 at beyondconference.com.
View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this "Ask Me Anything" (AMA) episode, Peter explores the topic of gray-market peptides, one of the most requested and most confusing topics he's covered on The Drive. Peptides sit at the intersection of biological plausibility, clinical promise, and aggressive commercialization, and are often marketed as cutting-edge therapies for everything from muscle repair and longevity to cosmetic enhancement. Rather than promoting or dismissing peptides wholesale, Peter lays out a clear, repeatable framework for evaluating any peptide or drug—covering mechanism, intended effects, safety, dosing, and alternatives. He distinguishes FDA-approved peptide therapeutics from the loosely regulated "peptides" common in biohacking culture; examines the strengths and limitations of animal and human evidence; unpacks manufacturing, gray-market sales, "research use only" labeling, and third-party testing; addresses oral peptides and absorption challenges; and explains how patents and incentives shape which compounds advance through clinical pipelines. The discussion concludes with a sober look at what would need to change for peptides to become broadly usable therapies, where legitimate peptide therapeutics may expand next, and which areas of medicine stand to benefit most right now. If you're not a subscriber and are listening on a podcast player, you'll only be able to hear a preview of the AMA. If you're a subscriber, you can now listen to this full episode on your private RSS feed or our website at the AMA #83 show notes page. If you are not a subscriber, you can learn more about the subscriber benefits here. We discuss: Setting the framework for evaluating peptides, and explaining the goal of this discussion [3:15]; What peptides are: basic definitions, biological roles, and therapeutic foundations [5:30]; A framework for evaluating peptides: mechanism, evidence, safety, and regulatory context [10:00]; Peptide case study—SS-31: mechanism of action, approved use in Barth syndrome, and other claimed effects [18:15]; Does the mechanistic rationale for SS-31 translate into measurable benefits? [22:15]; SS-31 continued: safety considerations, gray market risks, the balance of risk versus reward, and why it belongs in bucket #3 [26:00]; Peptide case study—melanotan-II: claimed effects, mechanism of action, safety, and side effects [30:45]; Melanotan-II continued: weighing the potential risks versus benefits and why it belongs in bucket #2 [36:30]; Peptide case study—CJC-1295: growth hormone–stimulating mechanism, claimed effects, and limited human data [40:15]; CJC-1295 continued: dosing uncertainty, risk-reward analysis, lack of long-term safety data, limited approved options, and why it belongs in bucket #2 [49:30]; Peptide case study—BPC 157: uncertain origins, broad claims, and weak mechanistic evidence [57:45]; BPC 157 continued: review of human evidence, lack of replication of animal data, safety considerations, risk-reward analysis, and why it belongs in bucket #1 [1:03:15]; Other popular "gray market" peptides and why they mostly fail when under scrutiny [1:11:15]; How the evidence on peptides compares to rapamycin, and why the lack of data is the biggest concern [1:20:00]; Understanding peptide regulation: FDA approval, supplement oversight, and the risks of gray-market compounds [1:23:00]; Inside the gray market: how peptides are sold, regulated, and why testing cannot guarantee safety [1:26:45]; Limitations of oral peptides, and examples of peptides in bucket #4 [1:31:45]; The future of peptides: real therapeutic potential versus hype in the wellness market [1:35:00]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube
Website: https://hunterwilliamshealth.com/Get my FREE Cheatsheet: https://hunterwilliamshealth.com/peptidecheatsheetJoin My Private Group: https://theaxioncollective.manus.space/Get My Book On Amazon: https://a.co/d/avbaV48DownloadSupplement Sources: https://hunterwilliamssupplements.carrd.co/Amazon Storefront: https://www.amazon.com/shop/hunterwilliams/list/WE16G2223BXA?ref_=cm_sw_r_cp_ud_aipsflist_R7QWQC0P1RACB2ETY3DYSocials:Instagram: https://www.instagram.com/hunterwilliamscoaching/Video Topic Request: https://hunterwilliamsvideotopic.carrd.co/One of the most common questions I get is which peptides I actually hate. And honestly, it's a fair thing to ask. You're spending real money on these compounds, so you deserve to know which ones might not be worth it.In this episode, I break down my five most overrated peptides. None of these are dangerous. Most have legitimate research behind them. They've just been surpassed by better compounds that cost about the same and work significantly better.I cover AOD-9604 and why the clinical trials underwhelmed, GHRP-2 and GHRP-6 and the cortisol and hunger problems they create, HGH Frag 176-191 and why it's somehow worse than AOD, Sermorelin and why I think it persists despite better options being available, and oral 5-Amino-1MQ capsules versus the injectable form.For each one, I share what I'd use instead. Tesamorelin, GLP-1 agonists, Ipamorelin with CJC-1295, and the injectable version of 5-Amino are all on the table.This isn't a hit piece. Every peptide on this list works for someone. I just don't think most people are getting their money's worth. Take it as one peer's honest opinion and test things for yourself.
Hunter Williams answers your March 2026 submitted questions across six categories — GLP-1s, growth hormone secretagogues, healing & injury recovery, metabolic peptides, men's health, and autoimmune support.Topics covered in this episode:Tirzepatide at max dose (15mg) — what to do when you've plateaued and how to transition to retatrutide safelyRetatrutide side effects — nausea, gut shutdown, sensitivity after restarting, and dose adjustmentsStacking tirzepatide and retatrutide — why it's not dangerous and the strategic reason to combine themCagrilintide + tirzepatide for appetite suppression and A1C managementGLP-1 non-responders — why some people don't respond and what to use insteadJardiance (SGLT2) alongside retatrutide — red blood cell considerations and cyclingBest peptide stacks for muscle building and body recomp on GLP-1sTesamorelin vs CJC-1295/Ipamorelin for belly fat and visceral fat reductionHGH vs peptide secretagogues for women 55+ — longevity, muscle, and brain healthGH secretagogues for female athletes with RED-S and absent menstrual cycleBPC-157 and anhedonia — dopamine effects and alternatives (TB-500, Cardilax, PEG-MGF, GHK)Pre and post-op peptide protocols for faster surgical recoveryMOTS-c, methylation mutations (MTHFR/COMT), and why some people feel more fatigued5-Amino-1MQ stacked with retatrutide — dosing caution and injectable vs oralMethylene blue, 9-ME-BC, Adamax, and Semax as nootropicsPeptides for hypothalamus and pituitary repair after brain tumor removalSelank, Noopept, and oxytocin for social anxiety and confidenceThymosin Alpha-1 for autoimmune disorders like lupusPost-prostatectomy libido restoration — testosterone, DHT, estradiol, and provironUrolithin-A and spermidine dosing for mitophagy and autophagyJoin the Axion Collective for live coaching calls every Thursday at 8PM Eastern. Submit your questions for next month's Q&A via the link in the description.Website: https://hunterwilliamshealth.com/Get my FREE Cheatsheet: https://hunterwilliamshealth.com/peptidecheatsheetJoin My Private Group: https://theaxioncollective.manus.space/Get My Book On Amazon: https://a.co/d/avbaV48DownloadSupplement Sources: https://hunterwilliamssupplements.carrd.co/Amazon Storefront: https://www.amazon.com/shop/hunterwilliams/list/WE16G2223BXA?ref_=cm_sw_r_cp_ud_aipsflist_R7QWQC0P1RACB2ETY3DYSocials:Instagram: https://www.instagram.com/hunterwilliamscoaching/Video Topic Request: https://hunterwilliamsvideotopic.carrd.co/
In this episode of Bathroom Diaries, I sit down again with Dr. Rob Frankel to talk about something most people have never heard of — somatopause. We talk a lot about menopause and andropause. But there is another hormonal shift that affects both men and women starting as early as their 30s: the gradual decline in growth hormone. This conversation is Part 4 of my Peptide Playbook series, where we explore how growth hormone signaling changes over time, why IGF-1 testing matters, and how peptides like tesamorelin, CJC-ipamorelin, and sermorelin may support the body's own natural growth hormone production. In this episode, we discuss: ✨ What somatopause actually is ✨ Why IGF-1 is the most useful marker to evaluate growth hormone decline ✨ How muscle loss, fat gain, fatigue, poor sleep, and brain fog may be connected ✨ The role of growth hormone analog peptides ✨ Why sleep quality and sugar intake affect nighttime hormone release ✨ How GLP-1 therapies support metabolic health and hormone balance ✨ The connection between fatty liver, insulin resistance, and longevity ✨ Who is (and is not) a candidate for peptide-based support ✨ The real clinical studies behind these therapies My goal with this series is simple: to demystify longevity medicine and bring medically responsible conversations about peptides into the open — so patients can make informed decisions with qualified physicians. Somatopause is rarely discussed, but understanding it can change how we think about aging, metabolism, cognition, and strength across the lifespan. If you're interested in hormone optimization, peptide therapy, or proactive aging strategies, this episode is for you. 00:00 Introduction – What is Somatopause? 02:05 Why Growth Hormone Declines After Age 30 04:10 IGF-1 Explained: The Best Marker for Growth Hormone 07:05 Symptoms of Somatopause (Muscle Loss, Fat Gain, Memory Changes) 10:20 Why Doctors Rarely Test Growth Hormone 13:05 Growth Hormone vs Growth Hormone Analogs 16:10 Tesamorelin, CJC-Ipamorelin & Sermorelin Explained 19:15 Are Growth Hormone Peptides Safe? 22:10 Growth Hormone Use in Athletes – What's Appropriate? 25:00 Why Peptides Are Cycled (Receptor Sensitivity Explained) 28:05 Sleep, Sugar & Somatostatin: Hidden Hormone Blockers 31:10 How Sugar Reduces Growth Hormone Production 33:20 GLP-1 Medications & Their Role in Hormone Optimization 36:15 Fatty Liver, Insulin Resistance & Longevity Risk 39:20 Tesamorelin Study: Reducing Visceral Fat by 40% 42:05 Traumatic Brain Injury Study & Growth Hormone Deficiency 45:00 Memory, Cognition & Executive Function Improvements 47:15 Who Should NOT Take Growth Hormone Peptides 49:05 Cost of Growth Hormone Analog Therapy 51:10 Best Blood Tests to Evaluate Somatopause (IGF-1 & Fasting Insulin) 53:00 Final Thoughts: Why Somatopause Matters for Longevity
Chris is out, Amy is in as are Hancock and Kelley for the whole first hour of the show; how awesome was Opening Day?; Michael and Matt partied hard; CJC locks don't work?; St Louis region sees a population loss, what can be done to stop that slippage?; what is the point of TSA?
Chris is out, Amy, Michael Kelley & John Hancock are in. Recapping the joy from Opening day; issues with the CJC; abolish the TSA?; Sarah Fenske from St Louis Magazine; Jen Siess talks CITY SC; plus why is America so miserable?
**In this webinar, industry experts explore the evolving regulatory landscape surrounding peptides like BPC-157, CJC, and other high-interest compounds that could potentially become eligible for pharmacy compounding and dispensing. ** **Show Notes:** 1. **Introduction and Housekeeping** [0:00] 2. ** Potential Legal Status Changes** [4:46] 3. **Impact of Legal Status Change** [11:35] 4. **Olympia Pharmaceuticals Update** [18:37] 5. **Product Offerings and Stability Testing** [24:10] 6. **Preparing for Peptide Market** [47:31] 7. **Legal and Compliance Considerations** [48:55] 8. **Q&A and Closing Remarks** [1:08:10] ----- #### **Becoming a Badass Pharmacy Owner Podcast is a Proud to be Apart of the Pharmacy Podcast Network**
On today's show, host Dana Pellebon is in conversation with District Attorney Ismael Ozanne about his office and the new community court that will help reduce racial disparities and recidivism in Dane County. DA Ozanne has a long history in Madison, from playing soccer at UW-Madison to overseeing the report on racial disparities commissioned by Governor Doyle. He says that in a city with a growing population and growing law enforcement, there aren't enough public defenders to represent the community. His office has 30 total prosecutors, but there should be 1 prosecutor for every 10,000 residents. Many of these positions are funded by the state, but others like the Victim Witness Program and Crime Response Program are funded by the county. DA Ozanne discusses how these offices work together and how they will connect to a new initiative out of the Community Justice Council (CJC). The CJC was created in 2008 and now works to take criminal justice decisions out of the criminal courts. The CJC is composed of major criminal justice leaders and aims to make evidence-based improvements and expand restorative courts with the goal of slashing recidivism rates, like similar programs in New York City and Chicago did. However, laws in Wisconsin mean that community courts have to take place in a courthouse, not in a more relaxed community setting. The new community court will be led by Circuit Judge Nia Trammell. District Attorney Ismael Ozanne is a lifelong resident of Madison, Wisconsin. He received his law degree from the UW Madison Law School in 1998 and was appointed as the Executive Assistant for the Department of Corrections (DOC), the largest cabinet agency in the state, by Governor Doyle in 2008. In 2010, he was appointed by Gov. Doyle to Dane County District Attorney and is the first African American District Attorney in Wisconsin's history. Featured image of District Attorney Ismael Ozanne. Did you enjoy this story? Your funding makes great, local journalism like this possible. Donate hereThe post A New Community Court is Coming to Dane County appeared first on WORT-FM 89.9.
Want the FULL deep dive on peptides? Join my exclusive peptide webinar and get the complete 2026 Peptide Reference Guide https://checkout.muscleintelligence.com/peptides Peptides are the future of healthcare — but what no one is telling you could be putting your health at risk. In this episode of the Muscle Intelligence Podcast, Ben Pakulski breaks down the entire 2026 peptide landscape, including the FDA status of 19 commonly used peptides, RFK Jr.'s recent announcement on Joe Rogan about reclassifying some common peptides, and why buying research-grade peptides from China could expose you to dangerous toxins hidden in that "99% pure" vial you're injecting. Ben walks through all 9 categories of peptides — from GH secretagogues like CJC-1295, ipamorelin, and sermorelin, to tissue repair peptides like BPC-157, TB-500, and GHK-Cu, to mitochondrial and longevity peptides like SS31 — explaining the critical difference between pharmaceutical-grade, compounding pharmacy products, and research-use-only sourcing. Whether you're exploring peptides for fat loss, muscle building, injury recovery, anti-aging, or brain optimization, this episode gives you the no-BS, science-backed framework to make informed decisions about peptide safety, peptide purity testing, and proper peptide sourcing in 2026. I f you're interested in working with Ben. ben@muscleintelligence.com Join 200,000 men in their prime, reading our weekly newsletter: http://muscleintelligence.com/newsletter
In this highly educational episode of Beauty Bytes, I sit down with Dr. Jason Pencek, a chiropractor and nurse practitioner who is highly trained in IV therapies and peptide protocols. We are tackling the "Wild West" of the current wellness space. With everyone from Pilates instructors to airline stewardesses suddenly selling peptides on social media, we break down exactly why you cannot afford to crowdsource your medical advice. We take a deep dive into the massive safety risks of buying "research grade" peptides online to save a few bucks, explaining how dangerous endotoxins and poor manufacturing can land you in the hospital. Jason outlines exactly what you need to look for in a legitimate 503A or 503B compounding pharmacy, including FDA registration and GMP certification. We also explore the nuances of hormone optimization. Jason explains why he prefers using Growth Hormone Secretagogues (like Tesamorelin and CJC-1295) to wake up your body's dormant cells, rather than shutting down your natural production with straight human growth hormone. Plus, we cover the most effective ways to administer NAD+ without sitting through a four-hour IV drip, and why checking your methylation and homocysteine levels first is an absolute must.
Dr Deb Muth 00:03Well, welcome back to Let’s Talk Wellness Now. I am your host, Dr. Deb. And what is the most talked-about peptides in functional medicine? aren’t actually FDA approved. Not because they don’t work, but because no one’s funded the research to prove it yet. The truth is, some of the compounds that dominate wellness forums, BPC-157, TB-500, thymosin beta-4, epitalin, occupy a fascinating space between breakthrough science and unregulated experimentation. In today’s episode, we’re stepping into that grey zone, the world of investigational peptides, to separate mechanism from marketing. I’m going to walk you through the science that actually shows and where it stops, how to evaluate claims when human data don’t yet exist, and the quality, purity, and safety red flags that you need to recognise. Dr Deb Muth 01:06I created it in a previous episode, so go check that one out. And why honesty is the most important prescription in peptide medicine. If you’ve ever wondered whether these research-only peptides are the frontier of healing or the next functional medicine fad, this episode is for you. So grab your cup of tea or coffee, get comfortable, and let’s talk about what it really means to use peptides that are promising but still under investigation. So we’re going to break just for a second here and have a word from our sponsor. It is because of them that we stay on the air. So thank you for this. And we will be right back. Did you know sweating can literally heal your cells? Infrared saunas don’t just relax you. They detox your body, balance hormones, and boost mitochondrial energy. I’m obsessed with my Health Tech sauna. And right now, you can save $500 with my code at healthtechhealth.com slash dr-muth-req-25. Dr. Deb Muth 02:15All right, guys, welcome back. Let’s dive into investigational peptides, the evidence gap. So the following peptides we’re about ready to discuss are extensively in integrative, functional, and regenerative medicine circles. They may have intriguing mechanisms and promising preclinical data. However, they lack FDA approval, and the evidence quality varies dramatically. from interesting preliminary research to essentially no human data at all. And this distinction is really critical for maintaining scientific integrity. So let’s talk about immune-modulating peptides. There’s thymus and alpha-1, and this is an international story on the thymic peptides. Thymusin alpha-1, known as TA1, is marketed internationally as zidaxin. Dr. Deb Muth 03:16It’s a 28-amino acid polypeptide originally isolated from thymusin fraction 5, which was extracted from bovine thymus tissue. Modern production uses synthetic peptide synthesis. The thymus gland is located behind the sternum and is the primary site for T cell maturation, and thymic peptides like TA1 play roles in human system development and regulation. Now, I love thymus peptides. I love thymus glandular products. I’ve used thymus glandular products for decades. Ground-up animal thymus gland is basically what it is. There are a couple of different supplement companies that I’ve used over the years that are amazing with this. And they do a fantastic job, and they really do help to support the immune system. So when thymus peptides came out, it was really exciting because it took the whole idea of thymus support to a new level. Dr. Deb Muth 04:17The mechanism actually behind the thymus in alpha-1 is complex and involves multiple aspects of immune function. At the cellular level, TA1 enhances T cell maturation and differentiation, particularly the development of helper T cells and cytotoxic T cells. It modulates T cell receptor expression and can influence the balance between Th1 cell-mediated immunity and Th2 humoral immunity responses. And it also enhances the natural killer cell activity and modulates dendritic cell function, which are critical for antigen presentation. and initiation of adaptive immune responses. And on the cytokine level, TA1 influences production of interleukin-2, IL-2, interferon gamma, IFN-γ, and interleukin-10, IL-10. Dr. Deb Muth 05:19These create immune modulatory rather than simple immune stimulatory effects. This is a very important distinction because TA1 appears to help balance the immune system rather than simply ramping this up, which theoretically makes it safer in conditions where immune overstimulation would be a problem, such as an autoimmune disease. Hashimoto’s, autoimmune, lupus, Sjogren’s, any of those autoimmune diseases, we don’t want to overstimulate their immune system. So you want to use a product like this that’s non-stimulating. Now, the regulatory status on TA1 is geographically variable and represents one of the challenges in discussing this peptide with patients. It is not FDA-approved in the United States. However, it is approved in several other countries for specific conditions. Dr. Deb Muth 06:19In Italy, it’s approved for the treatment of chronic hepatitis B and hepatitis C. In China, it’s approved for chronic hepatitis B and adjunct immune compromised patients receiving vaccinations or suffering from certain infections. It has an orphan drug designation in the United States for certain cancer indications, but its designation does not constitute approval. It simply provides regulatory incentives for further development. So the evidence base for thymosin alpha-1 is substantial in some areas but comes primarily from non-US populations and research groups, which creates challenges in evaluating quality and generalizable information. So in hepatitis B and C, multiple clinical trials, many conducted in China and Italy, have examined TA1 as an adjunct to antiviral therapy. Dr. Deb Muth 07:21A meta-analysis by Wu and colleagues published in the Journal of Viral Hepatitis in 2013 examined 23 randomized controlled trials, including over 2,000 patients with chronic hepatitis B. The analysis found that combining TA1 with nucleoside analogs like LAMVDUDE or an and TCAVAR improved the hepatitis antigen seroconversion rates by HBV DNA clearance compared to its nucleoside analogs alone. And the effect sizes were modest but statistically significant, with the HBE-AG seroconversion rates improving from about 24% with antivirals alone to 38% in combined therapy. Now in hepatitis C, early trials before the development of direct-acting antivirals showed that TA1 combined with interferon alpha improved sustained virological responses, and compared to interferon alpha, Dr. Deb Muth 08:30Furon alone, particularly in difficult-to-treat populations like those with a genotype one or a high viral load. However, the advent of highly effective direct acting antivirals that achieve SRV rates, sorry, SVR rates exceeding 95%, the role of TA1 in hepatitis C has become less clear. Now in sepsis and critical illness, more recent interest has focused on TA1 in severe cases of sepsis and septic shock. Ren and colleagues published a systematic review and meta-analysis in the Frontiers of Immunology in 2022, analyzing 18 randomized controlled trials, including 1787 patients with severe sepsis or septic shock the pooled analysis showed that ta1 administration was associated with reduced 28-day mortality relative risk at 0.70 meaning a 30 reduction in mortality compared to the standard care alone and the effect appeared Dr. Deb Muth 09:39most pronounced in patients with sepsis-induced immunosuppression measured by HLA-DR expression in monocytes. Now, this is amazing because going forward, we’re going to talk about something that’s commonly known as cytokine storm. Now, cytokine storm really became apparent since 2020 with the viral infection that we’re dealing with in the world today. But they were already looking at this kind of cytokine storm produced by sepsis or sepsis-induced immunosuppression. And it triggered this hyperinflammatory response called the cytokine storm. And many patients who survived the initial phase of the immune suppressed stata, characterized by a T cell exhaustion, reduced antigen presentation, and increased susceptibility to secondary infections. Thymusin alpha-1, TA1, may help restore this immune competence in this phase. However, it’s important to note that patient selection and timing are critical. Dr. Deb Muth 10:43Giving this immune stimulant during a hyperinflammatory phase could theoretically worsen outcomes. So you don’t want to give it to them while they’re in the flare up or the sepsis or the infection, but given to them during the immunosuppression phase afterwards might be beneficial. Now there is also some cancer immunotherapy that we see with TA1 and has been studied as an adjunct in cancer treatment with the hypothesis that it could enhance immune surveillance and response to tumors. And a comprehensive review of Garci and colleagues published in Expert Opinion on Biological Therapy in 2007 examined multiple trials in melanoma, lung cancer, hepatocellular carcinoma, and other malignancies. And the results were mixed. Some trials showed improvement in the immune parameters, increased CD4 in T-cells. improved lymphocyte proliferation responses and some actually showed trends toward improved progression free survival but overall survival benefits were inconsistent and the heterogeneity of the cancer types treatment protocols and outcome measures makes a definitive conclusion difficult as a vaccine adjunct several studies particularly from china have examined ta1 as an adjunct to enhance vaccine responses Dr. Deb Muth 12:11in immune-compromised populations, including the elderly, dialysis patients, and transplant recipients. The rationale is sound. These populations often mount suboptimal antibody responses to vaccines, and TA1’s immune-enhancing effects might improve protection. There are small trials. They have shown improvement in seroconversion rates of hepatitis B vaccines and influenza vaccine in these populations. And though large-scale confirmatory studies are limited, there is a possibility here. Now, on their safety profile, one of the appealing aspects of thymusin alpha-A TA1 is that it’s apparently favorable safety profile in clinical trials. There are some injection site reactions with a little redness, a mild discomfort, and most commonly reported adverse effects. is that their severe adverse events attributable to TA1 have been rare in published trials. However, comprehensive long-term safety data are limited Dr. Deb Muth 13:13And theoretically, concern exists that immune modulation could potentially trigger or exasperate autoimmune conditions in susceptible individuals. Though this hasn’t been clearly demonstrated in clinical trials, integrative medicine considerations for integrative practitioners concerning the thymus and alpha-1, several factors require careful thought. First, sourcing and quality control are critical concerns. Since it’s not FDA approved, TA1 available in the United States typically will come from a compounding pharmacy or an international supplier with variable quality assurance. And pharmaceutical grade product with certificates of analysis showing purity, sterility, and endotoxin testing is essential, but it is readily available from many of these companies. Second, patient selection matters immensely. TA1 should be considered in complex cases where conventional approaches have been insufficient, such as chronic viral infections not responding adequately Dr. Deb Muth 14:21to standard antivirals, post-viral syndromes with evidence of immune dysfunction, cancer patients with immune suppression in consultation with oncology, and it should generally be avoided in active autoimmune disease unless there’s a compelling rationale and close monitoring. Now, TA1 is not a standalone therapy. In cases of chronic viral infection, Comprehensive immune support includes addressing nutritional deficiencies, optimizing vitamin D levels to be between 50 and 80, adequate zinc, selenium, and vitamin A, optimizing gut health since 80% of our immune function is in the gut, you need to optimize gut function. Managing stress from the HPA access dysfunction, chronic cortisol elevation, suppression, and immunity, ensuring adequate sleep, immune memory consolidations during sleep, addressing any metabolic dysfunction, insulin resistance, repairs in the immune function, and the bottom line on thymus and alpha-1 is Dr. Deb Muth 15:26is that it represents legitimate medicine in other countries with a substantial evidence base in specific contexts, but it remains experimental in the U.S., and practitioners using it should provide comprehensive, informed consent about its regulatory status, evidence quality, and source verification. while ensuring it’s part of comprehensive protocols. It is not a magic bullet. And again, what you’re gonna hear me say quite often here is that many of these peptides should be used in conjunction with something else. They should not be used alone. And can peptides be stacked? The answer is yes, they can. So if somebody has an insulin resistance, or a metabolic dysfunction, they can tier TA1 with a GLP-1 like terzepatide or semiglutide. That is not a problem to do that. You need to just work with a practitioner that understands how to do that effectively. So let’s look at BPC-157. Dr. Deb Muth 16:26This is a phenomenon I love BPC-157. Let’s separate it from marketing to actual mechanism of actions here. So BPC-157 stands for Body Protection Compound 157. It is a chain of 15 amino acids that are described as a partial sequence of body protection compound, a protein found in human gastric juice. It has become one of the most hyped peptides in regenerative medicine inside the athletic performance and biohacking communities with claims ranging from healing tendons and ligaments to repairing gut lining or reversing organ damage. The challenge is separating the legitimate mechanisms of science from the marketing hype. The proposed mechanism of BPC-157 are biologically plausible and intriguing. The research suggests that it may influence several growth factor pathways, including vascular endothelial growth factor, VEGF, which promotes new blood vessel formation and has improved better supply of blood flow to injured tissues, theoretically accelerating healing. Dr. Deb Muth 17:40It may also affect fibrous blast growth factor, FGF, and transforming growth factor beta, TGF beta pathways. both involved in tissue repair and remodeling. And some studies actually suggest that BPC-157 modulates inflammatory cascades, potentially reducing excessive inflammation while promoting the resolution phase that allows tissue rebuilding. Now I want to talk just a few moments here about these different tests that we’re talking about tgf beta veg f for those of you who are in our mold world you are very familiar with these uh lab tests we do this to see if you have a mold exposure what’s happening to your body and it’s been very challenging to try to heal this part of the mold illness and manipulate these VEGFs and TGF betas. And so with the fact that BPC helps us modulate this inflammatory cascade, BPC can be very helpful in the world of mold or mycotoxin illness in repairing those parts of the body that have been damaged by the mycotoxins. Dr. Deb Muth 18:48Now there is animal research on BPC-157. It is extensive and primarily from a research group led by pre-drag, oh, I can never say these names, Cyrek at the University of Zagreb in Croatia. Published studies in animal models have shown accelerated healing in a remarkable variety of injury types. A 2011 paper by Chang and colleagues in the Journal of Applied Physiology demonstrated that BPC-157 improved therapy tendon healing in rats with Achilles tendon injuries, and the treated rats showed increased tendon outgrowth, better cell survival in the injured area, enhanced cell migration to the injury site, and improved biochemical strength of the healed tendon compared to controls. Multiple other animal studies have shown similar promising effects. Ligament tears, healing faster in rabbits, muscle damage recovering more quickly in rodent models, gastric ulcers healing in rats given experimental induced ulcerations, inflammatory bowel lesions improving in mouse models of colitis, and even bone to tendon healing showing enhancement in animal studies. Dr. Deb Muth 20:02The breadth of injury types showing benefit in preclinical models explains the enthusiasm of this peptide. However, this is critical. These animal studies, primarily in rodents and rabbits, animal models of injury healing don’t reliably translate to human clinical outcomes. And the doses used in these animal studies when converted to human equivalent doses vary widely. And optimal human dosing is completely unknown at this point. it is all considered experimental and perhaps most importantly there are essentially no peer-reviewed controlled clinical trials in human published in humans published in major medical journals in a 2001 review of arthroscopy and the journal of arthroscopic and related surgery specifically examined in the evidence of bpc 157 and other peptides in musculoskeletal medicine The authors concluded bluntly that BPC-157 lacks evidence from randomized controlled trials and has an unknown safety profile in humans. Dr. Deb Muth 21:09 They emphasized that the jump from animal data to recommending peptides for humans use bypasses the fundamental requirement for Phase I safety studies, Phase II dose-finding studies, and Phase III efficacy trials that would establish whether BPC-157 actually works in humans and whether or not it’s safe. The absence of human safety data is particularly concerning given BPC-157’s proposed mechanisms. Peptides that influence growth factor signaling and angiogenesis could theoretically have off-target effects. Uncontrolled angiogenesis, for instance, is a hallmark of cancer progression. Tumors require blood vessel formation to grow beyond a certain size. And while there’s no evidence that BPC 157 promotes cancer, The complete absence of long term human safety studies means we simply don’t know. This isn’t fear mongering. It’s acknowledging uncertainty and uncertainty exists and understanding that if you’re choosing to use peptides like BPC 157, you are doing it in an experimental model. Dr. Deb Muth 22:17We’re experimenting with the doses that are being used. And there is potential for it to cause cancer cells in your body to grow. And you need to be aware of this and understand the risks that you’re taking when you’re using an investigational or off label use peptide. Now, quality control issues with BPC also exist. It’s not FDA approved for any indication in the US. It’s not approved in any major regulatory jurisdiction worldwide. It’s marketed as a research chemical explicitly to bypass FDA oversight. And commercial sources selling BPC-157 range from compounding pharmacies, which have some quality standards but are not FDA inspected. You can take that for what you want to believe on that one. to overseas suppliers operating with absolutely no quality assurance whatsoever. If you are choosing to use BPC-157, you have to understand who’s manufacturing it for you, where you are getting it from, how pure it is. Dr. Deb Muth 23:26You want to make sure that you have the certificate of analysis and that it does not contain bacterial endotoxins that can contaminate the peptide or degrade the peptide and cause other issues for you. So when you talk about peptides with patients regarding BPC-157 or if you’re listening to this and you’re already using BPC-157 or other peptides, that are quote-unquote not for human consumption, an evidence-based response acknowledges both the appeal and the limitations. And you want to talk about the animal data that’s definitely showing some progress and some potential, but we don’t know what we don’t know in humans. If people are willing to take that risk, that is up to them to do that. But using BPC right now is experimental and people need to be aware of that. Are there evidence-based alternatives for patients with tendon or ligament injuries? Dr. Deb Muth 24:26And there are. There’s PRP, which has been studied in multiple randomized controlled trials. for conditions like lateral epicondylitis, tennis elbow, Achilles issues, patellar issues, knee issues. However, I want to caution you on this too. So the study that was done by Cox and colleagues in muscles, ligaments, and tendons in the Journal of 2014 showed modest benefits in pain and function compared to controls. And though the effects vary by injury type, PRP preparations can be helpful. You have to understand that a lot of times when people are doing PRP injections in their office, they are not doing it exactly the same way it was done in the study. And not to mention, if you’re using your own PRP to heal a ligament or a tendon or help your arthritis and you’re 60 or 70 years old, That is not good quality protein rich plasma. It is old protein rich plasma. And you’re not going to see necessarily the same benefits that you would see if you were using placental tissue or umbilical tissue. Dr. Deb Muth 25:33You also want to address the nutritional deficiencies or support that’s needed for connective tissue healing. And these are collagen peptides dosed at 15 grams a day. And this has been shown in a study by Shaw and colleagues in the American Journal of Clinical Nutrition in 2017 to augment collagen synthesis when combined with intermittent loading. Vitamin C is also an essential cofactor for collagen production and stabilization of collagen structure at a dose of around 500 to 1000 milligrams a day to support this process. You also need to have good adequate intake of copper and zinc. These are cofactors in collagen. Silica is also important. This comes from horsetail extract. This provides additional support as well. So more importantly, I think remembering that rehabilitation matters as well. Doing these protocols without doing some rehab is not going to get you where you want to go. Dr. Deb Muth 26:33There’s a research study by Alfredson and others for Achilles tendinopathy using the control lengthening of muscle tendon units under load to promote tendon remodeling and healing. These protocols have solid evidence and cost nothing beyond professional guidance from a physical therapist. They are important for patients seeking cutting edge regenerative approaches. Stem cell therapies, growth factors, concentrates derived from patients’ own tissues like PRP. These have a lot of good endogenous materials and they have good safety profiles. BPC-157 represents the perfect example of how promising Preclinical science gets marketed far beyond the evidence and it may eventually prove to be valuable. I think it will. But right now that determination does require some human studies and hopefully with the administration that we have right now and Bobby Kennedy, we will actually start to see some of that occur. Now the next peptide I want to talk about is TB4, thymus and beta-4. Dr. Deb Muth 27:36This is a wound healing peptide. It is a 43 amino acid peptide that’s naturally present in virtually all human cells except red blood cells. It’s actually one of the most abundant peptides in the human body, particularly concentrated in blood platelets, wound fluid, and many tissues. It’s naturally ubiquity makes it mechanistically interesting. The body wouldn’t produce it in such abundance if it didn’t serve a function. So the primary role of TB4 involves building G-actin. It’s a form of monomeric actin. And it’s structural protein that forms the microfilaments within the cells, providing cellular structure and enabling cell movement. TB4 prevents from F-actin filaments. I’m not going to talk too much about this. It’s really critical for wound healing as cells need to migrate into the injury sites. Dr. Deb Muth 28:37so the cell shape changes and the cellular response to the injury. So think of this as though you tore your meniscus and the body created all this TB4 to come to that injury to try to heal that site. That’s exactly what the TB4 is doing inside the body when there’s an injury. It’s been shown in research to help produce new blood vessel formation, promote endothelial cells, It helps modulate inflammatory cytokines, potentially reducing TNF-alpha, IL-1, and possibly protecting in programmed cell death, which we call apoptosis. And some studies suggest that it is cardioprotective in its effects in animal models of myocardial infarction, so heart attack, and neuroprotective in other models for brain injury. Now, these remain to be preliminary, but they are being seen. So the regulatory status on TB4 can create some confusion. Dr. Deb Muth 29:40The natural TB4 molecule itself is not FDA approved as a drug. However, TB4 based drug candidates called RGN259, formerly TB4, has been in the development by regen tree for corneal injuries of the dry eye disease. And as of recent updates, this drug is completed phase three trials for its neurotrophic keratopathy, severe corneal condition. But the FDA approval is still pending. So that means that the most advanced TB4-based pharmaceuticals hasn’t yet crossed the finish line for approval. The commercial peptide market further muddies the picture with TB500, which is often described as the synthetic fragment of TB4. However, this extract’s relationship between TB500 and TB4 varies depending on the source. Dr. Deb Muth 30:41So some claim that TB500 is identical to TB4, but positions 1 through 4 suggest it’s a different fragment. and the quality control across suppliers is not existent. So this confusion is part of why recommending TB500 becomes problematic for practitioners and patients, often because they aren’t certain what molecule they’re actually getting. The evidence base for TB4 in humans is limited, primarily to eye research, and the studies from Sohn’s and colleagues published in journals like Vitamins and Hormones in 2016 have examined topical TB4 for corneal injuries and neurotrophic keratopathy, dry eye, and other surface diseases. Now, these studies showed some promise in promoting this, and there is, however, a topical application to the cornea that is vastly different from a systemic injection. So for systemic use in wound healing, musculoskeletal issues, Dr. Deb Muth 31:42cardiac protection, neuroprotection, human clinical trials. There is scarce to non-existent evidence in humans. Most of the evidence remains in animal models or cell culture studies. And a review by Flip and colleagues in the Journal of Investigational Dermatology in 2006 detailed TB4’s effects on the matrix remodeling during wound repair in animal models, showing effects on collagen disposition, granulation, tissue reformation, and wound contraction. Another review by Ho and colleagues in expert opinion on biological therapy in 2007 discussed TB4’s potential in tissue regeneration and regenerative medicine, but noted the field remained largely blank. preclinical. So this is really important again to understand that there is just not enough human data. So there is a concern with cell division and migration. This theoretically exists Dr. Deb Muth 32:45for the potential effects on cancer cells, which would also rely on migration and division and other intended consequences of disrupting normal cellular architecture. These aren’t proven risks, but they are unexplored questions that we need to be aware of when we’re using peptides. This can cause cancerous tissue to grow. Very similar to what we talked about with BPC-157. These are also sold as research chemicals. There is no FDA oversight. So purity, potency, contaminations all still exist for these peptides. Now from an integrative perspective, the natural presence of TB4 in wound fluid and its biological roles in healing are legitimate science. in presence does not equal therapeutic utility. The body tightly regulates where and when and how much TB4 is present through natural production and bypassing that regulation with external dosing may or may not cause us to have beneficial or introduce risk. Dr. Deb Muth 33:49So we need to know that this is experimental use. Those people who are seeking wound healing and tissue repair the evidence-based approach of the body’s own capacity to heal is huge definitely want to be increasing your protein intake optimizing your zinc copper vitamin c and vitamin a and then managing glucose is really important during this time as well so let’s talk about a fun topic now and that’s growth hormone secretagogues this is the anti-aging hype machine these peptides in this category are things like semoralin ipameralin cjc 1220 1295 and others and among the most aggressively marketed in anti-aging and longevity medicine they all share a common goal stimulating the pituitary gland to release more growth hormone and the appeal is understandable. GH levels decline with age, and this decline is associated with increased fat mass, decreased lean muscle, reduced bone density, and other aspects of aging. Dr. Deb Muth 34:55The other times we’ll see growth hormone levels decline significantly is with chronic illness, and the logic is to restore youthful GH levels and youthful physiology. Now, semirelin from an FDA approved diagnostic to compound anti-aging product. Semirelin is a 29 amino acid peptide representing the first 29 amino acids of the full 44 amino acid human growth releasing hormone, GHRH. We talked about this on another episode of the podcast. And you can go back and listen to that one a little bit if you want. This fragment contains the complete biological activity of the full GHRH molecule and it binds to GHRH receptors in the anterior pituitary and stimulates growth releasing peptides, growth hormone releasing peptides. Semirelin was previously FDA approved as diagnostic testing of growth hormone secretion, essentially, to determine if the pituitary could still respond to GHRH stimulation in patients being evaluated for growth hormone deficiency. Dr. Deb Muth 36:06However, the manufacturer was discontinued and there was no longer an FDA approved semirelin product on the market in the United States. What exists now is semirelin available from compounding pharmacies used off label for anti-aging, body composition, and general growth hormone optimization purposes. This represents a significant gray area. Again, compounding medications serve a very important role, but they need to meet certain recommendations and regulations, as we’ve talked about in the past. You want to make sure that your compounding pharmacy that you’re obtaining semirelin from is qualified to do that, that they are doing best practices, and that you’re getting a good product. The theoretical advantage to semirelin over direct growth hormone administration is that it preserves more of the physiological growth hormone secretion patterns. Natural GH is released in pulses, primarily during sleep, not as a continuous elevation. Dr. Deb Muth 37:07So semirelin stimulates the pulses rather than providing a constant super physiological growth hormone level. And that pulsatile pattern is thought to reduce some of the side effects and metabolic concerns that we have with continuous growth hormone exposure. However, the evidence supporting semirelin for anti-aging and body composition in healthy adults is minimal. Most of the data comes from studies conducted in the 1990s when the FDA approved product existed. Not that that means it’s bad. We have drugs that have been in the market for over a hundred years that are still there, that still have the research and are still being used successfully and safely today. So we don’t want to let that really make us think that this product isn’t safe. So a 2006 review from Walker in Clinical Interventions of Aging suggested that semirelin might be a better approach than direct GH for adult onset growth hormone insufficiency, but they do acknowledge that the evidence was limited. Dr. Deb Muth 38:12And although we don’t have any large scale trials that we can examine for semirelin’s efficacy, it is now commonly prescribed. And the optimal dosing for anti-aging purposes is still unknown. It is considered experimental and it does vary from person to person, but it is still unstudied. The effects on cancer risk, cardiovascular disease, metabolic dysfunction over long time periods are also still unknown. I would argue that the side effects or the risk factors of not having growth hormone are equally as bad as the unknowns that we have here. We’re not looking to try to get super physiological doses. We’re trying to restore youthful GH levels. Typically, we’re not trying to restore back to a 20-year-old. We’re trying to restore back maybe 10 years. That is a better way of doing this. And I think that’s important for people to understand. Now, ipamirelin is the ghrelin mimicker. Dr. Deb Muth 39:12Ipamirelin is a pent-up peptide, five amino acid, that acts as a growth hormone secretagogue receptor, a GHS-R agonist. It mimics the action of ghrelin, the hunger hormone, that also stimulates growth hormone release. The proposed advantage over earlier secretagogues is that ipamirelin stimulates growth hormone release without significantly affecting cortisol, prolactin, or other glucose things, which can be increased by growth hormone secretagogues. The regulatory status is clear. Ipamirelin is not FDA approved for any indication. It’s sold as a research chemical. Human evidence is thin. It’s limited to single dose studies examining how quickly it’s absorbed and metabolized with minimal data on dosing and clinical outcomes. Now there are marketing claims for ipamirelin and they are extensive. Dr. Deb Muth 40:13It increases lean muscle mass, it decreases body fat, it improves sleep quality, faster recovery from workouts, enhanced injury healing, better skin quality. The evidence supporting these claims in humans is not available we don’t have it these are claims that are made by the effects that we know from growth hormone so it’s not necessarily a bad thing we know what growth hormone does we know growth hormone does all of these things if ipamorelin is a precursor to that it will obviously help improve those things making that correlation of what growth hormone does So there are safety concerns that mirror the same as any other growth hormone elevating therapy. It can cause fluid retention, joint pain, carpal tunnel syndrome, insulin resistance, glucose intolerance, and theoretically, can it increase calcium? cancer risks? It can because IGF-1 promotes cell proliferation and can inhibit apoptosis in cancer cells. Now remember, your body makes IGF-1. Dr. Deb Muth 41:15If it’s not making enough of it, that’s a problem. If it’s making too much of it, That’s a problem. So just understand that if you are adding these things, and especially in elevated doses, you are taking a potential risk. So there is also now CJC 1295 is a modified GHRH analog of 30 amino acid peptide based on GHRH structure, but with modifications. So it includes the addition of drug affinity complex, DACC, DAC, which involves conjugation with a small albumin binding molecule, dramatically extends the peptide’s half-life from minutes to as much as potentially a week or more. And this creates sustained growth hormone elevation rather than that pulsatile release. There are actually two versions of this. There’s CJC 1295 with DAC, longer acting version, and CJC 1295 without DAC, which is essentially a shorter duration of semirelin. Dr. Deb Muth 42:19And so when we’re comparing products, it is… only the difference between long acting and short acting. The human evidence for CJC 1295 is limited to a single published phase one study by Techman and colleagues in the Journal of Clinical Nutrition and Metabolism in 2006. And the study involves 18 healthy young adults showed that CJC 1295 with DAC produced a sustained elevation of GH and IGF-1 lasting several days after the injection. That’s essentially the entire published human evidence of this peptide. There are no phase two studies examining optimal dose. So that is all considered experimental. And there is no phase three studies examining clinical efficacy. So the sustained GH levels created by CJC 1295 with DAC raises specific concerns because the natural GH secretion It goes up and down, up and down, up and down. Dr. Deb Muth 43:19And that constant elevation may have a different metabolic and cellular effect. And we just really don’t know what that’s going to be yet. So we can understand that elevated IGF-1 levels can theoretically increase cancer concerns and metabolic risks. So rather than always injecting peptides, which are very expensive… You can do other things. And there was a study by Hartman and colleagues in the Journal of Clinical Endocrinology and Metabolism in 1992 that demonstrated the 48-hour fast increased integrated growth hormone secretion five-fold through increased GH levels. Now, the problem with this is fasting for 48 hours is a challenge. And how long is it going to increase the growth hormone secretion without causing issues? Or in general, how long is it going to go up? Dr. Deb Muth 44:19So we have to be cautious about that as well. Sleep optimization is non-negotiable. The majority of growth hormone secretion occurs during sleep, slow wave sleep, typically the first sleep cycle, and poor sleep quality or insufficient sleep typically. can dramatically affect your growth hormone levels. And then high intensity interval training, HIIT resistance training can stimulate growth hormone as well. This was seen in a study by Godfrey and colleagues in sports medicine in 2003 and was examined in exercise-induced growth hormone responses to athletes. So we definitely see these kinds of things. So let’s talk about some longevity peptides now. These expand the telomere. So there’s epitalin and epithalamin and when these are used in anti-aging they can produce some amazing results. Dr. Deb Muth 45:22So epitalin is a synthetic terapeptide, just four amino acids. It was originally synthesized as a simplified version of epithalamine. a pineal gland extract containing multiple peptides. The synthetic four amino acid version was created to isolate what researchers believed might be the active anti-aging component. The mechanism produced for epitalin centers on telomere and telomerase, Telomeres are protective caps at the end of the chromosomes consisting of repetitive DNA sequencing. And every time a cell divides, telomeres shorten slightly because DNA polymers cannot fully replicate the ends of the linear chromosomes. So this progressive shortening acts as a molecular clock. After 50 or 70 divisions, the telomeres become critically short, triggering a cellular senescence. Dr. Deb Muth 46:22This telomere shortening is one mechanism of cellular aging and telomeres in the enzyme that can rebuild telomeres by adding these caps back onto the end of the chromosome. It’s active in stem cells, germ cells, and unfortunately in about 85 to 90% of the cancer cells. In most adult somatic cells, telomerase is inactive or present at very low levels, allowing the telomeres to shorten with division. The research on epitalin suggests it might activate this telomeres act telomeres process primarily from a research group led by Vladimir in Russia. Vladimir Kavasan in Russia. He is a huge peptide researcher or was he passed away with publications dating back to the early 2000s and a study published in bio gerontology in 2000 by Kavasan Dr. Deb Muth 47:25and colleagues examined the effect of epitalin on the lifespan of fruit flies, and they treated fruit flies that showed a modest increase in mean and maximum lifespan compared to its controls by approximately 10 to 15% lifespan extension in some experimental groups. And there were other studies in 2003 that examined epitalamine in a female Swiss-derived mouse. This was done by Ann Simove and colleagues. And the researchers reported that epitalin treatment was associated with increased lifespan as well. And the most cited mechanistic work comes from cell culture studies. And that is also Cavason’s group that published this research in 2003, showing increased telomeres activity in cultured somatic cells again. More recently, between 20 and 25, the series of publications have continued to explore epithelial effects on telomere dynamics in cell cultures. Dr. Deb Muth 48:32So there is a lot of research that’s been done. The mass majority has been done on epithelin. And most of it has been done by a single research group in Russia. There is some restrictions on some of the cell culture data that we’re seeing. And it does show that epithelin sometimes can be described as a regulating hormone. Carcadian rhythm for melatonin production, which is derived by the penile extracts. And however the evidence for this affects minimally and mechanistically unclear, the pineal gland primarily functions as melatonin secretion in that light-dark cycles. So Epithalin or epitalin is not FDA approved. It is not approved for any major regulatory jurisdiction. It is sold as a research chemical only. Dr. Deb Muth 49:33So you need to follow the same safety profiles that we’ve talked about in other episodes and in today’s episodes. And when we’re talking about epithalin, and we’re excited about it being an anti-aging science, we should balance this with the honesty and the evidence of the quality of that evidence. We don’t know its safety effect. We don’t know if it’s going to increase the risk of cancer. We can’t verify that. And we need to be using it in an experimental use of unknown risks only. Of course, diet, physical activity, stress management, sleep quality, all of those things are important for us to be looking at when we’re looking at these peptides. Now, I want to get into some of the brain peptides. This is the nootrophic frontier. C-Max and C-Lank, there is Russian pharmacology that’s done. C-Max and C-Lank represent an interesting case study in how different regulatory environments and research traditions Dr. Deb Muth 50:36create challenges in evaluating this evidence. Both peptides were developed in Russia, are approved for their specific indications and have substantial Russian language and literature supporting their use. However, the FDA approval in the United States is still not there. C-Max is a seven amino acid. It’s a synthetic analog. It is a fragment, particularly ACTH 4 through 10. It’s sometimes called the melanocortin effects because it involves the melanocortin receptors of the central nervous system. CMAX was developed by the Institute of Molecular Genetics of Russia Academy of Sciences and is approved in Russia for several indications, including acute stroke, transient ischemic attacks, cognitive disorders. It has Russian approval and is based on clinical trials primarily in Russia. Dr. Deb Muth 51:39It does help to increase brain-derived neurotrophic factor, BDNF, a protein critical for neuroplasticity, the brain’s ability to form new connections and adapt to the challenges. BDNF supports neuronal survival and promotes growth of these new neurons. C-Max also influences neurotransmitter systems, particularly dopamine and serotonin, and there is some research that suggests it affects on metabolism as well, and endogenous opioid peptides that involve pain reception and mood regulation. So it has some good potentials there. There is also C-Link, which is a hepatopeptide structurally similar to Tufts’ and an immune modulatory peptide. It was also developed in Russia and was approved for anxiety disorders as a neurotropic. Its effects involve anxiolytic effects, possibly through the GABAnergic system or the GABA system of the brain, and immune modulation. Dr. Deb Muth 52:44The Russian research is examined by C-Link for anxiety disorders. and finding reductions in anxiety without sedation. There is a dependency potential or cognitive impairment does not exist like it does with benzodiazepines with C-Link. So that is really good. And they do report attention and memory improvement using C-Link. There is a study that was done in neuroscience and behavioral psychology in 2018 that examined C-Linx effects and proposed that it exerts cytoprotective effects through BDNF pathways similar to C-Max. So both of these are Russian research-based They’re not wrong or fraudulent. It’s just that they are from Russia and we all have our concerns with Russia. However, that does not necessarily mean their research doesn’t hold quality. Dr. Deb Muth 53:49Neither peptide is approved by the FDA, and so you are using this off-label. The same rules apply for all of the other peptides that we’ve talked about that are produced off label. You want to do the same things that you would do with anything else. Good protein, omegas, B vitamins, acetylcarnitine, exercise, sleep, all of that still applies when we’re using these peptides. So I want to talk briefly about clinical decision and framework when we’re looking at this. First and foremost, we always want to go to FDA-approved peptides. Secondly, we would look at international approval with peptides that are established in other countries but lack FDA approval. And then preclinical evidence only or experimental peptides. These can be used, but they are not ethically recommended in the traditional medicine world. Dr. Deb Muth 54:50 If patients use them, we need to have appropriate counseling about the evidence surrounding them, the safety, and where to find them. how to find them and how to ask for these certificates of analysis. So I think it’s really good that we were exploring all these peptides and understanding what they are. There’s a lot of controversy out there. There’s a lot of concern out there. And what we can say with confidence is that peptides are powerful biological signaling molecules. Some peptide based medications, semi-glutide, triseptide, PT 141, Lupron that are all FDA approved. can dramatically improve outcomes in patients that are obviously selected for the correct ones. There are many other peptides that we address that are integrative and longevity space in the regenerative medicine. These peptides are all experimental. That does not automatically make them wrong. Dr. Deb Muth 55:50It just means that we need to be honest about what we’re doing with them and we need to be cautious with the patients so that they can make a decision to be part of an experimental study. in looking at how to use these peptides. So peptides are tools like any other tools. They work best in the hands of skilled people, and they are applied to appropriate situations, integrating into comprehensive approaches that address root causes. The most powerful peptide administered to a patient with untreated inflammation, hormonal chaos, nutritional deficiencies, and disorders of sleep will disappoint. The simplest evidence-based interventions apply. to a patient whose foundational physiology has been optimized. And this is the art of the science of peptide, right? If done right, respecting both the power of these molecules and the complexity of human beings that we are privileged to serve can make a difference in their lives. So thank you for listening to this episode. Dr. Deb Muth 56:52I hope this was helpful. If you can know of somebody that might benefit from this, please like, share, and subscribe. It means a lot to us. And I hope you join us for our next episode of Let’s Talk Wellness Now. Welcome to Let’s Talk Wellness Now, where we bring expert insights directly to you. Please note that the views and information shared by our guests are their own and do not necessarily reflect those of Let’s Talk Wellness Now, its management, or our partners. Each affiliate, sponsor, and partner is an independent entity with its own perspectives. Today’s content is provided for informational and educational purposes only and should not be considered specific advice, whether financial, medical, or legal. While we strive to present accurate and useful information, we cannot guarantee its completeness or relevance to your unique circumstances. We encourage you to consult with a qualified professional to address your individual needs. Dr. Deb Muth 57:54Your use of information from this broadcast is entirely at your own risk. By continuing to listen, you agree to indemnify and hold Let’s Talk Wellness Now and its associates harmless from any claims or damages arising from the use of this content. We may update this disclaimer at any time and changes will take effect immediately upon posting or broadcast. Thank you for tuning in. We hope you find this episode both insightful and thought-provoking. Listener discretion is advised.The post Episode 258 – Investigational Peptides: What's Promising, What's Hype & What You Must Know first appeared on Let's Talk Wellness Now.
The peptide trend is everywhere…in wellness clinics, on influencer feeds, and now inside coaching programs promising six- and seven-figure practices built on injectable protocols. But what does the actual science say?In this episode, we sit down with Dr. Lauren Colenso-Semple, Ph.D., a research scientist and contributing author at MASS Research Review whose sharp, no-nonsense breakdowns of health and exercise science have made her one of the most trusted voices for evidence-based practitioners. She joins us to dissect her viral article The Peptide Problem… and pull absolutely zero punches.We go deep on the three most hyped peptide drugs circulating in the wellness space right now (CJC-1295, Ipamorelin, and BPC-157), and the uncomfortable truth that their bold promises of muscle gain, fat loss, accelerated recovery, and anti-aging are built almost entirely on rodent data. Zero approved human trials. Zero FDA oversight. Zero manufacturing standards. Yet coaches are being handed pre-built protocols and told this is the new standard of care.Dr. Colenso-Semple explains why "natural" doesn't mean safe, why anecdotal success stories aren't evidence, and what the real risks, including tumor angiogenesis and immune reactions, could look like for everyday people injecting unapproved compounds. She also gives coaches a clear playbook for navigating client pressure, ethical red flags to watch for in mentorship programs tying coach income to selling unapproved drugs, and the evidence-based tools that actually move the needle when you strip the hype away.If you're a coach, trainer, or health professional trying to stay on the right side of science and your integrity… this one is essential listening Coach VinnyEmail: vinny@balancedbodies.ioInstagram: vinnyrusso_balancedbodiesFacebook: Vinny Russo Dr. ErynEmail: dr.eryn@balancedbodies.ioInstagram: dr.eryn_balancedbodiesFacebook: Eryn Stansfield Dr. Lauren Colenso-SempleInstgram: drlaurencs1Website: https://www.drlaurencs.com/Mass Research Review Article: https://massresearchreview.com/2026/02/26/the-peptide-problem/ LEGION 20% OFF CODEGo to https://legionathletics.com/ and use the code RUSSO for 20% off your order!
March 3, 2026: Your daily rundown of health and wellness news, in under 5 minutes. Today's top stories: Temple raises $54M for temple-worn wearable continuously measuring brain blood flow to quantify focus, fatigue, and cognitive resilience in real time MyFitnessPal acquires AI-native Cal AI with $40M+ in sales, deepening push into digital nutrition tracking across 280M registered members HHS plans to reclassify 14 peptides including BPC-157 and CJC-1295 back to Category 1, enabling licensed compounding pharmacies to produce them with prescription More from Fitt: Fitt Insider breaks down the convergence of fitness, wellness, and healthcare — and what it means for business, culture, and capital. Subscribe to our newsletter → insider.fitt.co/subscribe Work with our recruiting firm → https://talent.fitt.co/ Follow us on Instagram → https://www.instagram.com/fittinsider/ Follow us on LinkedIn → linkedin.com/company/fittinsider Reach out → insider@fitt.co
Join My Private Group: https://theaxioncollective.manus.space/Email List: https://huntershealthhacks.beehiiv.com/Get My Book On Amazon: https://a.co/d/avbaV48DownloadThe Peptide Cheat Sheet: https://peptidecheatsheet.carrd.co/Download The Bioregulator Cheat Sheet: https://bioregulatorcheatsheet.carrd.co/1 On 1 Coaching Application: https://hunterwilliamscoaching.carrd.co/Book A Call With Me: https://hunterwilliamscall.carrd.co/Supplement Sources: https://hunterwilliamssupplements.carrd.co/Amazon Storefront: https://www.amazon.com/shop/hunterwilliams/list/WE16G2223BXA?ref_=cm_sw_r_cp_ud_aipsflist_R7QWQC0P1RACB2ETY3DYSocials:Instagram: https://www.instagram.com/hunterwilliamscoaching/Video Topic Request: https://hunterwilliamsvideotopic.carrd.co/In this episode, I'm diving deep into Mast Cell Activation Syndrome, or MCAS, and why it's such a big topic in the peptide world. If you've been around peptides long enough, you've probably seen it — certain people react strongly to compounds like CJC, ipamorelin, or other common peptides, and suddenly they're dealing with flushing, hives, GI distress, tachycardia, or brain fog.I break down what MCAS actually is, why some people are genetically predisposed, and why others develop it from environmental triggers, infections, autoimmune issues, or nervous system dysregulation. I also explain why traditional antihistamines often fall short — because they treat symptoms, not the upstream immune imbalance.Then I walk through my comprehensive MCAS stack: LDN, Thymosin Alpha-1, Thymalin, KPV, VIP, PEA, and even GLP-1 receptor agonists. I explain the mechanisms, dosing strategies, when to introduce each one, and how to think about this in phases instead of expecting a magic bullet.This isn't a cure-all, but it's what I've seen work coaching hundreds of people. If you're sensitive to peptides or trying to get back to baseline after reactions, this episode will give you a structured roadmap.
Peptides can change how you heal, lean out, build muscle, and age, but only if you stop taking influencer advice and start thinking like a scientist. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR -Get a discount from BIOLONGEVITY LABS by using code ‘Dave' at: https://biolongevitylabs.com/ Host Dave Asprey sits down with Josh Felber and Jay Campbell for a deep, practical conversation on what peptides actually are, how they work in the body, and how to use them without doing something dumb. Josh Felber and Jay Campbell are both cofounders of BioLongevity Labs and longtime leaders in the peptide and performance space. Josh is also the host of the Making Bank podcast and a serial entrepreneur in health. Jay has spent more than a decade researching and teaching advanced peptide protocols and performance strategies. They break peptides down in plain English as chains of amino acids that act like signaling molecules, then get into what matters in the real world: delivery methods, dosing, and why pharmacokinetics and timing decide whether something works. You'll hear why peptide pens feel like a huge upgrade over vials and syringes, why Dave wants patches and microneedle tech next, and how convenience can make the difference between consistency and quitting. Dave and the guys also go deep on mitochondria and longevity. They talk about SS31, now called elamipretide, and why it focuses on mitochondrial membranes and cardiolipin. They cover MOTS-c as a “turbocharger” peptide that people often feel fast, especially if they feel metabolically sluggish. They get into growth hormone peptides like Tesamorelin, Ipamorelin, and CJC, plus why MK-677 sounds convenient but can come with tradeoffs like appetite and other downstream effects. Then the conversation turns into what's new. Jay shares what he claims is a new long-acting folistatin-style compound called FLGR 242, designed to stay active for weeks. He frames it as a potential solution for GLP users who worry about losing muscle. They also talk about Klotho, what it does in aging, why it is hard to stabilize, and why Jay believes small dosing matters because of kidney risk at higher levels. Dave ties Klotho back to endothelial function and kidney protection, and they swap stories about what people report noticing. You'll Learn: • What peptides are, explained without jargon • Why delivery matters and why pens beat mixing vials all day • How PK curves change real results and dosing schedules • What elamipretide means for mitochondria and longevity • Why MOTS-c can feel like a fast energy shift for some people • How Tesamorelin, Ipamorelin, and CJC fit into growth hormone support • Why MK-677 sounds easy but can bring unwanted effects • What Jay claims FLGR 242 does for myostatin, muscle, and fat loss • Why Klotho shows up in longevity research and why dose matters Thank you to our sponsors! • 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Generation Lab | Go to https://www.generationlab.com/ and use code Dave20 for $20 off to see what your body is really doing beneath the surface. • Pique | Establish a powerful foundation for sustained wellness at https://www.piquelife.com/DAVE and unlock 20% off. • Vibrant Blue Oils | Grab a full-size bottle for over 50% off at https://vibrantblueoils.com/dave Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: peptides, biohacking, Dave Asprey, Jay Campbell, Josh Felber, BioLongevity Labs, mitochondrial peptides, elamipretide SS31, MOTS-c, growth hormone peptides, Tesamorelin, Ipamorelin, CJC-1295, MK-677, folistatin, myostatin inhibitor, FLGR 242, Clotho peptide, longevity science, anti-aging, human performance, muscle growth, fat loss, GLP-1 muscle preservation, pharmacokinetics, peptide dosing, nootropics, functional medicine, metabolism, endothelial function, kidney protection Resources: • Get a discount from BIOLONGEVITY LABS by using code ‘Dave' at: https://biolongevitylabs.com/ • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 0:00 – Trailer 1:22 – Introduction to Peptides 7:52 – Peptide Delivery Systems & Pens 14:22 – Safety & Regulation of Peptides 19:22 – SS-31 & Mitochondrial Health 26:22 – Blending Peptides & Cross-Linking 38:22 – Growth Hormone Peptides 44:22 – FLGR-242: The New Myostatin Inhibitor 54:22 – Melanin & Consciousness 57:22 – Klotho: The Longevity Peptide 59:25 – Regulatory Landscape & Future of Peptides See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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What if the most powerful biohack is simply getting the morning sun in your eyes and letting your wearables prove it works? We explore Medicine 4.0 with Steven Stavrou DCM, a South African physician-biohacker who blends Chinese and functional medicine with hard data, showing how ancestral habits and modern metrics can drive prevention, performance, and genuine wellbeing.We start with incentives and shift them toward staying well, then build a plan from baseline labs, HRV, sleep, and body composition. You'll hear why the first 90 minutes of the day set your circadian rhythm, how breath work and heat-cold routines can move stress scores, and how to personalize movement so VO2 gains don't cost you muscle or hormones. We unpack a practical supplement strategy—vitamin D, the right magnesium forms, creatine, and sleep-supportive amino acids—while making the case for quality over quantity and partnering with trusted clinicians instead of buying mystery gummies online.From there, we connect mitochondria to cognition and mental health, advocating for a “cognoscopy” to objectively track brain performance. We discuss the evolving landscape of peptides—BPC-157, TB-500, CJC-1295, and more—highlighting both the promise and the need for careful governance. Purpose and community aren't afterthoughts; they're central to metabolic health and resilience. With coaching as the bridge, complex plans become small, repeatable wins that compound over months into sustainable transformation.If you're ready to stop guessing and start measuring—while keeping your routine simple and human—this conversation offers a clear path. Subscribe, share with a friend who needs a reset, and leave a review with the one habit you're adding this week.https://stevestavs.com/Continue this conversation on SubStack: https://robertlufkinmd.substack.com Lies I Taught In Medical School : Free sample chapter- https://www.robertlufkinmd.com/lies/Complete Metabolic Heart Scan (LUFKIN20 for 20% off) https://www.innerscopic.com/Fasting Mimicking Diet (20% off) https://prolonlife.com/Lufkin Web: https://robertlufkinmd.com/X: https://x.com/robertlufkinmdYoutube: https://www.youtube.com/robertLufkinmd Instagram: https://www.instagram.com/robertlufkinmd/LinkedIn: https://www.linkedin.com/in/robertlufkinmd/TikTok: https://www.tiktok.com/@robertlufkinThreads: https://www.threads.net/@robertlufkinmdFacebook: https://www.facebook.com/robertlufkinmd Blu...
Did you know that using peptides the wrong way can actually decrease their effectiveness, and that most people are missing the foundational steps that make them work?In this episode of The Well Drop, I sit down with Sarah Morgan, clinical nutritionist and founder of InstaMed, to explore how peptides truly function, when to use them, and why cycling is the key to long-term effectiveness.We dive into differences between oral, injectable, and buccal peptide delivery methods, unpack GHK‑Cu, the most underrated beauty peptide for skin and hair, and discuss how to slot peptides into your midlife health stack without skipping the basics. We also break down why “more” isn't always better, how to recognize peptide burnout, and why lifestyle, hormones, and supplements should support each other, not compete.Sarah Morgan brings over a decade of clinical nutrition practice in Denver, combined with her expertise launching InstaMed's buccal peptide technology. As a health innovation expert and founder, she's translating complex science into accessible, practical wellness tools and helping shift the peptide narrative from hype to real, lasting results.What's Discussed: (00:00) The real role of peptides in health and longevity(04:38) How oral peptide delivery works, and why it's a game-changer(17:09) The right way to cycle peptides for long-term results(25:27) GHK-Cu, CJC-1295, and the peptides transforming skin, sleep, and strength(37:53) What responsible peptide use actually looks like(44:13) Why play is just as essential as any protocolThank You to Our Sponsors:Sign up for The Well Drop NewsletterFind out more about Amber Berger: Website: www.thewelldrop.com Instagram: www.instagram.com/thewelldropFind out more about Sarah Morgan:Website: https://getinstamed.com/ Instagram: https://www.instagram.com/instamedstrips/ Instagram: https://www.instagram.com/sarahmorgan.co Website: https://www.sarahmorgan.co/
Dr. Jones clarifies how the combination of CJC-1295 and Ipamorelin can enhance growth hormone production and release. He elucidates the science in this peptides explained video, highlighting the potential health benefits his patients have experienced with ipamorelin and peptide therapy. Understand how these growth hormone-stimulating compounds work together.CHAPTERS00:00 What Are CJC-1295 and Ipamorelin?01:00 How They Work Together to Boost Growth Hormone02:00 The Well-Known Benefit: Muscle Growth & Fat Loss03:04 Surprising Benefit #1: Deep Restorative Sleep03:39 Surprising Benefit #2: Sharper Focus & Brain Function04:08 Surprising Benefit #3: Joint, Tendon & Ligament Repair04:37 Surprising Benefit #4: Improved Skin Health & Elasticity05:05 Surprising Benefit #5: Stronger Bones & Osteoporosis Prevention05:46 Final Thoughts & How to Learn MoreConnect with Dr. Greg JonesInstagram: @doctorjones_doctorjones Enovative Wellness Center: https://enovativewellness.com/
Join My Private Group: https://theaxioncollective.manus.space/Email List: https://huntershealthhacks.beehiiv.com/Get My Book On Amazon: https://a.co/d/avbaV48DownloadThe Peptide Cheat Sheet: https://peptidecheatsheet.carrd.co/Download The Bioregulator Cheat Sheet: https://bioregulatorcheatsheet.carrd.co/1 On 1 Coaching Application: https://hunterwilliamscoaching.carrd.co/Book A Call With Me: https://hunterwilliamscall.carrd.co/Supplement Sources: https://hunterwilliamssupplements.carrd.co/Amazon Storefront: https://www.amazon.com/shop/hunterwilliams/list/WE16G2223BXA?ref_=cm_sw_r_cp_ud_aipsflist_R7QWQC0P1RACB2ETY3DYSocials:Instagram: https://www.instagram.com/hunterwilliamscoaching/Video Topic Request: https://hunterwilliamsvideotopic.carrd.co/Timestamps:00:14:36 – “What big trend in peptides do you see becoming popular?” 00:19:40 – “Using GLP-2 twice per week… how to switch to GLP-3 for maintenance?” 00:22:00 – “It's hard to keep muscle mass on GLPs – what peptides help?” 00:23:36 – “Any peptides that stimulate hunger or appetite?” (Jay)00:24:10 – “Did you experience anhedonia on RETA?”00:31:00 – “IGF-1 LR3 stability – does it lose effectiveness after reconstitution?”00:31:56 – “Does oral GLP (orforglipron) have benefits beyond appetite suppression?” 00:33:30 – “What is your New Year's protocol / what are you experimenting with?”00:36:59 – “Good starter protocol with SS-31, MOTS-C, BPC-157, Ipamorelin, CJC, RETA?”00:39:46 – “Glutathione injections causing soreness – normal?” 00:40:00 – “How to reduce water retention on growth hormone peptides?” 00:41:30 – “Low iron in a 21-year-old, fatigue, and peptides for depression?”00:43:24 – “Taste changes on RETA – is that common?”00:44:16 – “Can GLPs cause hair thinning?”00:44:34 – “Thoughts on Klotho?”00:45:02 – “Why Ipamorelin over Tesamorelin for women?”00:45:34 – “Peptide cheat sheet dosing – AM/PM split clarification?”00:46:29 – “Will RETA ever be oral? (needle-averse)”00:47:59 – “Best way to get Jardiance without Bitcoin?”00:48:59 – “Any info on Stamakort-10?”00:50:57 – “Can GLPs help reduce alcohol cravings?”00:53:05 – “Can you talk more about MOTS-C?”00:54:15 – “Does metformin deplete B-vitamins?”00:55:14 – “Does topical GHK-Cu work for skin benefits vs injectable?”00:57:39 – “Bioregulator capsules vs injectable effectiveness?”01:03:26 – “Post-viral upper respiratory recovery – would VIP help?”01:04:48 – “Best place to get testosterone for women?”01:14:04 – “Insomnia on RETA – causes and fixes?”01:21:25 – “Do you recommend topical estrogen?”01:34:09 – “Growth hormone peptides after thyroid cancer – safe?”01:37:14 – “Progesterone causes mood issues – alternatives?”
Dr. Dwayne Jackson—a powerhouse in the world of performance, resilience, and peptide science. With decades of experience from pro motocross and bodybuilding to scientific research and personal health transformation, Dr. Jackson shares how his pursuit of peak performance shaped his journey, from building race cars with his family to pioneering new approaches to athletic recovery and executive wellness. Together, Chris and Dr. Jackson explore the parallels between elite athletes and high-performing professionals, diving deep into blood work, inflammation, mitochondrial health, and optimizing hormones. Expect practical insights into peptide usage, the importance of setting up the right physiological "terrain," and a close look at recovery tools like exogenous ketones and breakthrough mitochondrial peptides. Listen to the episode for: Actionable tips if you're navigating the aftermath of years of hard training, stress, or PEDs. Effective peptide protocols for sleep and recovery (e.g., CJC 1295, Ipamorelin) The role of exercise and proper timing of hormone/peptide use Check out Dr. Dwayne Jackson: vitalitymanifesto.com On Instagram @drdnjackson for daily insights His upcoming Vitality Manifesto podcast: http://www.youtube.com/@vitalitymanifesto This episode of the ARCHITECT of RESILIENCE podcast is available on Apple, Spotify & YouTube, and is sponsored by: Enhanced Executive Peptides: https://shop.enhancedexecutive.com 00:00 Bodybuilding, Motocross, and Recovery 09:40 Athlete Health Decline in Mid-30s 12:40 Inflammation, Glucose, Insulin: A Trifecta 22:05 "Health First, Peptides Second" 29:52 "Optimizing Hormones with Natural Rhythms" 35:06 Steroid Dosing and Side Effects 41:18 Estrogen's Role in Male Hormones 47:22 Oxidative Stress and Endothelial Health 50:37 Mitochondrial Enhancers for Performance 01:05:13 "Ketones for Recovery and Sleep" 01:07:49 "Ketone Absorption Timing Explained" 01:13:15 Mitochondrial Health & HIT Training 01:18:18 Achilles Mobility and Training Reflections Drop your most surprising lesson from this thread or your peptide questions in replies! #Resilience #PerformanceScience #PeptideTherapy #Longevity #Biohacking #Podcasts Learn & Connect at https://chrisduffin.com/ • SHOP: Explore my books and products in the store. • EDUCATE: Unlock access to my incredible Education Portal featuring hundreds of hours of courses and thousands of guided movement videos, all conveniently indexed for easy navigation.
Making Billions: The Private Equity Podcast for Startup Founders and Venture Capital Investors
Send us a text"RAISE CAPITAL LIKE A LEGEND: https://go.fundraisecapital.co/frc2-apply"DOWNLOAD "The Dollar Empire Private Markets Playbook"https://go.fundraisecapital.co/dollar-empire-playbookThe financial world is fixated on the wrong metrics. While the media screams about US debt and the trade deficit, these perceived weaknesses are actually the hidden engines driving trillions of dollars directly into private equity, private credit, and venture capital. This is not theory—it's accounting.In this deep-dive masterclass on global macro strategy and private market investing, Ryan Miller rips the curtain back on the Balance of Payments (BOP)—the true master ledger of global power. If you are a fund manager or deal syndicator, you need to know exactly how the Current Account deficit forces foreign capital to buy your deals. The world isn't collapsing; it's buying American assets, and your fund is the mechanism.Subscribe on YouTube:https://www.youtube.com/channel/UCTOe79EXLDsROQ0z3YLnu1QQConnect with Ryan Miller:Linkedin: https://www.linkedin.com/in/rcmiller1/Instagram: https://www.instagram.com/makingbillionspodcast/X: https://x.com/_MakingBillionsWebsite: Pure Tested Peptides - GLP-3, BPC 157, CJC-1295, ipamorelin, ss-31, epithalon, SLU-pp-332 99% pure research peptides for longevity muscle and metabolic healthSupport the showDISCLAIMER: The information in every podcast episode “episode” is provided for general informational purposes only and may not reflect the current law in your jurisdiction. By listening or viewing our episodes, you understand that no information contained in the episodes should be construed as legal or financial advice from the individual author, hosts, or guests, nor is it intended to be a substitute for legal, financial, or tax counsel on any subject matter. No listener of the episodes should act or refrain from acting on the basis of any information included in, or accessible through, the episodes without seeking the appropriate legal or other professional advice on the particular facts and circumstances at issue from a lawyer, finance, tax, or other licensed person in the recipient's state, country, or other appropriate licensing jurisdiction. No part of the show, its guests, host, content, or otherwise should be considered a solicitation for investment in any way. All views expressed in any way by guests are their own opinions and do not necessarily reflect the opinions of the show or its host(s). The host and/or its guests may own some of the assets discussed in this or other episodes, including compensation for advertisements, sponsorships, and/or endorsements. This show is for entertainment purposes only and should not be used as financial, tax, legal, or any advice whatsoever.
A SEAT at THE TABLE: Leadership, Innovation & Vision for a New Era
Sometimes the most difficult challenge senior leadership faces is finding purpose in their work. It's not that they don't care about the company or their teams. It's a more subtle sense that something is missing. The job is no longer fulfilling. That they are stagnating or are meaningless in their roles.This can be particularly perplexing when overall you are successful at what you do – and it's not like there's something else that looks a lot better.Today we are joined by the fabulous Marla Bace. Having successfully navigated several career transitions herself, Marla now helps senior leadership find renewed purpose in their work – or identify what their next - more fulfilling - role might be.In this episode of A Seat at The Table, Marla will share Why leadership needs to look beyond self-awareness and emotional intelligence, and lean into intuition and purpose in order to find work that aligns with them.Practical strategies for senior executives who are facing career boredom that can help reignite excitement and identify strategic pivots.Balancing data-driven decisions with intuition to build greater team engagement and loyalty.This episode is part of our new Leadership Edge series.We developed this series because while performance gets you in the room.Presence is what makes people listen.We're unpacking the leadership skills that help you stand out—create real influence, earn loyalty, and build the right relationships.Because visibility isn't luck. It's built.USEFUL LINKS:Connect with Marla Bace on LinkedIn: https://www.linkedin.com/in/marlabace/Marla Bace's website: http://www.marlabace.com/Pure Tested Peptides - GLP-3, BPC 157, CJC-1295, ipamorelin, ss-31, epithalon, SLU-pp-332 99% pure research peptides for longevity muscle and metabolic healthVisit A Seat at The Table's website at https://seat.fm
Send us a textHey beautiful souls!In today's episode I'm talking all about:Platonic intimacy What if relationships aren't all bad?Why I don't need a roster (& taking the pressure off my roster search) Removing the moochers from my life before I could elevate and ascend& SO MUCH MOREWant to join my pleasure oasis? CLICK HERE: https://www.loveatiya.com/theetherealpleasureacademyWanna learn how to pleasure yourself to your higher self? CLICK HERE: https://www.patreon.com/TheLoveAtiyaExperience Sex Education Instagram: https://www.instagram.com/loveatiya/Sex Education TikTok: https://www.tiktok.com/@iloveatiya?Sex Positive Podcast: https://theloveatiyaexperience.buzzsprout.comYouTube: iloveatiya https://www.youtube.com/@iloveatiya/videos Pure Tested Peptides - GLP-3, BPC 157, CJC-1295, ipamorelin, ss-31, epithalon, SLU-pp-332 99% pure research peptides for longevity muscle and metabolic healthSupport the show
In this episode of The Everyday Ironman Podcast, Mike and Ashley sit down with Kyle Axman for a wide-ranging conversation that blends endurance sport, fitness tech, and a little friendly chaos. Kyle and Ashley first crossed paths at the NYC Marathon Expo, and the conversation takes off from there. Kyle works with Technogym, makers of the Skill Run treadmill designed to deliver real-time biofeedback and advanced running metrics. That sparks Mike's pitch for a future where form-fitting fabric provides muscle-engagement feedback during a run. Kyle also shares his unconventional path from pursuing an acting career to teaching spin classes, growing up with a dad who qualified for the Ironman World Championship, and why he and his wife proudly call themselves group fitness junkies. Plus, Ashley finally reveals the real reason she hates Pickleball.#TheEverydayIronman #AgeGroupAthlete #TriathlonLife #EnduranceTraining #FitnessTechnologyFit, Healthy & Happy Podcast Welcome to the Fit, Healthy and Happy Podcast hosted by Josh and Kyle from Colossus...Listen on: Apple Podcasts Spotify Pure Tested Peptides - GLP-3, BPC 157, CJC-1295, ipamorelin, ss-31, epithalon, SLU-pp-332 99% pure research peptides for longevity muscle and metabolic healthSupport the show
Send us a textIn this episode Luke, Josh and Zac talk about how to use a shot timer for everything in your shooting journey.Intro/Outro Music:Music: Awakening by Lucjo / lucjomusic License: Creative Commons — Attribution-NoDerivs 3.0 Unported — CC BY-ND 3.0Free Download / Stream: https://www.audiolibrary.com.co/lucjo...Music promoted by Audio Library: • Cinematic, Electronic, Trap No Copyright M... Pure Tested Peptides - GLP-3, BPC 157, CJC-1295, ipamorelin, ss-31, epithalon, SLU-pp-332 99% pure research peptides for longevity muscle and metabolic healthSons Of Liberty Gun WorksA superior manufacture of high quality, hard-use, direct impingement freedom tools.Green OpsCome train with us. Blue Force GearBlue Force Gear, manufactures (MOLLE) gear, firearm slings, and other tactical equipment.TenicorThe official holster of the Green Ops PodcastGriffin ArmamentGriffin Armament Suppressors, the only suppressors that the guys from Green Ops use and recommend.Disclaimer: This post contains affiliate links. If you make a purchase, I may receive a commission at no extra cost to you.Please like, subscribe and share to help us grow the podcast.Check out our YouTube:https://www.youtube.com/c/GreenOpsInc Follow us on Instagram:Green Ops Podcast - Green_ops_podcastGreen Ops - greenopsincLuke - Green_Ops_LukeDex - Green_Ops_DexLove you Mom!
Ageless Athlete - Fireside Chats with Adventure Sports Icons
What really keeps the brain sharp as we age — and what quietly puts it at risk?In this episode of the Ageless Athlete Podcast, host Kush Khandelwal speaks with Dr. Tommy Wood, neuroscientist, physician, and strength athlete, about the science of cognitive reserve and why long-term brain health depends on challenge, learning, and effort — not comfort or flow.Flow states feel rewarding, but as Dr. Wood explains, they don't create the kind of stimulus the brain needs to adapt over decades. Instead, the brain thrives when it's pushed to learn new skills, navigate uncertainty, and stay engaged through physical movement, mental effort, and diversified identity.This conversation connects neuroscience, exercise science, and psychology in a practical, accessible way — especially for adults who care about aging well, staying mentally sharp, and maintaining performance into midlife and beyond.
Send us a textin this episode, Annie and Mr. discuss their trip to a nude beach and an evening at. the Museum of Sex...Pure Tested Peptides - GLP-3, BPC 157, CJC-1295, ipamorelin, ss-31, epithalon, SLU-pp-332 99% pure research peptides for longevity muscle and metabolic healthSupport the showIntro music by Poor Man's Poison. Check them out, they're amazing! Don't forget to check out Annie's erotica on Kindle and Amazon, found under Annie Goodman. You can also find us at Annieandmra.com, on Facebook as Annie Goodman, and Instagram and Twitter (X) as @AnnieandMrA.
In this episode of Creating Your Ageless Future, Regan Archibald delivers a powerful deep dive into the science of body composition, metabolic aging, and the peptides reshaping modern regenerative medicine. He breaks down the “Ageless Axis”—the brain, muscle, and heart—and explains how blood sugar, inflammation, mitochondrial function, and visceral fat determine how quickly we age. Regan shares emerging breakthroughs in GLP-1s, Tesamorelin, CJC-1295, AOD9604, and the “Wolverine stack” (BPC-157 + TB500), and reveals how peptides act as metabolic reset systems rather than dependency-forming drugs. Along the way, he celebrates real client transformations, exposes misconceptions about weight loss drugs, explains why muscle is the antidote to gravity, and updates listeners on new Ageless Future pharmacy innovations. This episode is part science class, part biohacking blueprint—everything you need to build a younger, stronger, more resilient future. AGELESS FUTURE:Book Comprehensive Labs: https://agelessfuture.com/longevity-labs/FREE copy of The Peptide Blueprint: https://agelessfuture.com/blueprintSign up for future Health Accelerator Challenges calls LIVE! https://us02web.zoom.us/webinar/register/WN_YZsiUMOzSyqcE8IinC5YEQ#/registrationBooks: https://www.amazon.com/Books-Regan-Archibald/s?rh=n%3A283155%2Cp_27%3ARegan%2BArchibaldArticles: https://medium.com/search?q=Regan+ArchibaldLIKE/FOLLOW/SUBSCRIBE AGELESS FUTURE:YouTube -https://www.youtube.com/@ReganArchibald / https://www.youtube.com/@Ageless.FutureLinkedIn: https://www.linkedin.com/in/regan-archibald-ab70b813Instagram: https://www.instagram.com/ageless.future/Facebook: https://www.facebook.com/AgelessFutureHealth/DISCLAIMER: Here's the info scoop: everything on this channel is purely for educational and informational kicks—definitely not medical advice. We're here to share the good stuff on wellness and longevity, but let's be clear: the FDA hasn't signed off on any of it. Our aim? To inspire and inform, not play doctor. So before diving headfirst into any health crusade, check in with your healthcare pro. Absorb, explore, and stay curious!
In this power-packed episode of The Super Human Life, Coach Frank sits down with Chris Duffin — legendary strength athlete, mechanical engineer, entrepreneur, and one of the most respected voices in human performance and biological optimization. Chris shares his unbelievable story of survival, resilience, and reinvention, and reveals a framework that's helping high-performing men rebuild purpose, identity, and physical vitality — especially after career success turns into stagnation, burnout, or loss of drive. Whether you're a business leader, former athlete, father, or high performer who knows you're capable of more, this episode will challenge you and equip you to break through the plateau and reclaim the edge. About Chris Duffin Chris "The Mad Scientist" Duffin is a world-record-setting powerlifter, bestselling author, biomechanical genius, and the founder of Kabuki Strength and multiple human-performance companies. He has worked with: Every major league baseball team 90% of the NBA 80% of the NFL Elite military operators Hollywood action performers High-net-worth executives + former steroid-enhanced athletes After surviving a traumatic upbringing and rising to become a top executive, world-class strength athlete, and multimillion-dollar founder, Chris devoted his life to helping people build resilience and optimize human biology for peak performance and longevity. He now coaches individuals and professionals through biomechanics, peptides, mitochondrial repair, hormone optimization, and cellular-level resilience. Key Takeaways ✔ Comfort is the new danger. Men don't just break down at rock bottom — many collapse at rock top after success leads to stagnation and meaninglessness. ✔ Growth requires resistance. Just like muscles atrophy in a cast, the mind and soul weaken without intentional challenge. ✔ The Six P's of Growth: Precipice → Plunge → Pit → Pole → Peak → Plateau You must choose the plunge before life forces you into it. ✔ Fear isn't the enemy. True strength is remaining self-aware inside stress — neither paralyzed by fear nor reckless without it. ✔ Mindset alone is not enough. If your biology is compromised — hormones, mitochondria, inflammation — you're fighting your own physiology every day. ✔ Modern men can reclaim energy and clarity. Peptides, hormone alignment, mitochondrial support, and circadian rhythm optimization can reverse brain fog, low drive, recovery issues, and emotional instability. ✔ The Superhuman life = value-aligned living. Not achievement — but building a life where your actions express who you were created to be. Peptides & Optimization Mentioned Chris shares a high-level overview of cutting-edge regenerative and performance-boosting tools, including: CJC-1295 + Ipamorelin (GH optimization) TRT micro-dosing aligned with circadian rhythm BPC-157, TB-500, KPV (gut & tissue repair) Alcar, ketones, urolithin A (metabolic support) SLUPP 3-3-2, MOTS-C, SS-31 (mitochondrial restoration) (Not medical advice — consult a qualified professional before applying.) --- Connect with Frank and The Super Human Life on Social Media: Instagram: https://www.instagram.com/coachfrankrich/ Facebook: https://www.facebook.com/groups/584284948647477/ Website: http://www.thesuperhumanlifepodcast.com/tshlhome YouTube: https://www.youtube.com/channel/UCjB4UrpxtNO2AFtDURMzoKQ
Send us a textIn this episode, Dex and Luke break down the Green Ops Alumni Drill of the Month — a challenge designed to keep your training sharp and your skills progressing. They dive into the purpose behind the drill, key performance standards, common pitfalls shooters face, and tips for making the most out of your practice sessions.Whether you're part of the Green Ops Alumni group or just looking for new ways to improve your range sessions, this episode is packed with practical advice, pro-level insights, and a few laughs along the way.Intro/Outro Music:Music: Who Is by tubebackr & Stanty / tubebackr Creative Commons — Attribution-NoDerivs 3.0 Unported — CC BY-ND 3.0Free Download / Stream: https://audiolibrary.com.co/tubebackr...Music promoted by Audio Library: • Who Is – Dance Background Music | tubeback...Pure Tested Peptides - GLP-3, BPC 157, CJC-1295, ipamorelin, ss-31, epithalon, SLU-pp-332 99% pure research peptides for longevity muscle and metabolic healthSons Of Liberty Gun WorksA superior manufacture of high quality, hard-use, direct impingement freedom tools.Green OpsCome train with us. TenicorThe official holster of the Green Ops PodcastGriffin ArmamentGriffin Armament Suppressors, the only suppressors that the guys from Green Ops use and recommend.Disclaimer: This post contains affiliate links. If you make a purchase, I may receive a commission at no extra cost to you.Please like, subscribe and share to help us grow the podcast.Check out our YouTube:https://www.youtube.com/c/GreenOpsInc Follow us on Instagram:Green Ops Podcast - Green_ops_podcastGreen Ops - greenopsincLuke - Green_Ops_LukeDex - Green_Ops_DexLove you Mom!
We unpack the buzz around growth hormone peptides like CJC-1295, Ipamorelin, and Tesamorelin—what they are, how they work, and why they're more than just “bodybuilder tools.” We break down how these powerful peptides can aid fat loss (especially belly fat), boost deep sleep, support muscle growth, and sharpen focus—if used properly. You'll also learn how to avoid common mistakes, like overstimulating your system or triggering insomnia and inflammation. If you've ever wondered whether peptides are the missing piece of your wellness journey, this one's for you. CONNECT
Jessica Hicklin co-founded Unlocked Labs while serving what she thought would be a life sentence in Potosi Correctional Center. She taught herself how to code using the prison's library books, and when she was released in January 2022, the company grew from there. Unlocked Labs provides secure software on computers for detainees to access educational content. It is available in state prisons in five states across the country, and the St. Louis City Justice Center is the first jail to receive the service. Bretton Delaria from the Office of Violence Prevention, which collaborated with Unlocked Labs and the CJC on this rollout, joins Hicklin on the show to discuss the company's current efforts and goals for the future.
In this episode of the Inspire Health by Jen Podcast we dive into Men's Health. This one's for the men — husbands, dads, brothers, and bros. Jen shares how to build real strength, balance hormones, and reconnect with your purpose. We talk about everything from physique, to food, to hormones to spirit. Jen Shares personal stories and experiences with her own husband and father around their healing journey and transformation. Fella's we NEED you. Themes: Physique: Eat clean, train daily, hydrate with lemon + mineral water, and cut seed oils, gluten, dairy, and soy. Fasting: Try intermittent fasting to burn fat and preserve muscle. Peptides: Support recovery, muscle growth, sleep, and libido (Sermorelin, CJC, BPC-157, Kisspeptin). Hormones: Testosterone and DHEA are game changers for energy and sexual health — skip the quick fixes and get tested. Spirit: True health includes a spiritual practice — breathwork, prayer, meditation, or joining a men's group. Connect with Jen:
Curious about peptides? This episode is your ultimate crash course on anti-aging, weight loss, recovery, and hormone optimization, straight from the expert himself, Chris Morris, PA-C, co-owner of Nulevel Wellness & Medspa.We cover everything you need to know:What peptides are and why they're the future of medicineHow peptides can increase muscle, speed recovery, and boost metabolismThe “Glow Protocol” for youthful skin, collagen production & fine-line reductionSnap-8 vs Botox: a needle-free way to soften expression linesThe Wolverine Protocol for rapid injury recovery & pain reliefPeptides that improve libido, brain fog, focus, and moodSleep support: why CJC-1295/Ipamorelin & DCP can transform your restHow to make peptides and hormone therapy affordable & accessible
In this solo episode, Lindsey dives into the world of peptide injections, with a focus on the controversial “Wolverine shot” (BPC-157). She explores what peptides are, why they're trending in gyms, wellness clinics, and med spas, and how they're marketed for muscle gain, fat loss, recovery, and anti-aging.Lindsey discusses the science (and lack thereof), FDA concerns, and potential risks like overdosing, contamination, and unregulated use. She closes by reminding listeners that while peptides are intriguing, true health and longevity still come from foundational practices—quality sleep, nutrition, strength training, and meaningful human connection. Listen in to learn more : 01:03 – Why People Use PeptidesClaimed benefits include lean muscle gain, faster recovery, testosterone support, fat loss, and anti-aging. However, the evidence base is thin.01:18 – BPC-157 and Other PeptidesBPC-157: derived from stomach peptides, believed to speed up tissue healing and reduce inflammation.Tesamorelin: studied for HIV-related fat reduction.Sermorelin: targeted for sleep and recovery.CJC-1295 + Ipamorelin: growth hormone–related stacks are popular among bodybuilders.02:28 – Lack of Scientific EvidenceMost data comes from animal studies or small trials, not significant human clinical research.03:55 – FDA ConcernsThe FDA flagged four peptides in 2022; that number jumped to 26 by the end of 2023, showing rapid regulatory scrutiny.04:42 – Anecdotal Use by Doctors and CEOsSome report success with peptides like BPC-157 for injuries, but even they acknowledge the lack of robust science.05:35 – Risks of Overuse and ContaminationOverdosing risks: especially when combining peptides with testosterone, leading to organ enlargement.Contamination/mislabeling: Many peptides sold are unregulated, increasing health risks.06:15 – Back to Basics for LongevityDespite the hype, proven health strategies remain the same: sleep, exercise, protein, reducing sugar, strength training, and social connection.Become a supporter of this podcast: https://www.spreaker.com/podcast/the-lindsey-elmore-show--5952903/support.
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