Podcasts about pffs

Lee Camp digs into the recent Venezuelan elections, 10 horrible things hidden inside Trump's "beautiful" bill, and moreTo learn more about Chapter Medicare Advice, call 757-349-8232 or go to AskChapter.org/Camp *Chapter: Chapter and its affiliates are not connected with or endorsed by any government entity or the federal Medicare program. Chapter Advisory, LLC represents Medicare Advantage HMO, PPO, and PFFS organizations and stand alone prescription drug plans that have a Medicare contract. Enrollment depends on the plan's contract renewal. While we have a database of every Medicare plan nationwide and can help you to search among all plans, we have contracts with many but not all plans. As a result, we do not offer every plan available in your area. Currently we represent 50 organizations which offer 18,160 products nationwide. We search and recommend all plans, even those we don't directly offer. You can contact a licensed Chapter agent to find out the number of products available in your specific area. Please contact Medicare.gov, 1-800-Medicare, or your local State Health Insurance Program (SHIP) to get information on all of your option.*Average potential savings are based on realized premium, co-pay, and out of pocket savings estimates self-reported by consumers that worked with Chapter Advisory LLC to enroll in a Medicare Supplement, Medicare Advantage, and/or Part D Prescription Drug Plan. The average is limited to consumers that chose to self-report. Savings information is subject to periodic updates and corrections. There is no guarantee of savings and any savings may vary by policy type, state, or other factors.

The former Israeli Prime Minister Ehud Olmert has accused Israel of war crimes. Plus the US and Germany have decided to remove all range restrictions for Ukraine.To learn more about Chapter Medicare Advice, call 757-349-8232 or go to AskChapter.org/Camp *Chapter: Chapter and its affiliates are not connected with or endorsed by any government entity or the federal Medicare program. Chapter Advisory, LLC represents Medicare Advantage HMO, PPO, and PFFS organizations and stand alone prescription drug plans that have a Medicare contract. Enrollment depends on the plan's contract renewal. While we have a database of every Medicare plan nationwide and can help you to search among all plans, we have contracts with many but not all plans. As a result, we do not offer every plan available in your area. Currently we represent 50 organizations which offer 18,160 products nationwide. We search and recommend all plans, even those we don't directly offer. You can contact a licensed Chapter agent to find out the number of products available in your specific area. Please contact Medicare.gov, 1-800-Medicare, or your local State Health Insurance Program (SHIP) to get information on all of your option.*Average potential savings are based on realized premium, co-pay, and out of pocket savings estimates self-reported by consumers that worked with Chapter Advisory LLC to enroll in a Medicare Supplement, Medicare Advantage, and/or Part D Prescription Drug Plan. The average is limited to consumers that chose to self-report. Savings information is subject to periodic updates and corrections. There is no guarantee of savings and any savings may vary by policy type, state, or other factors.

Lee Camp and Eleanor Goldfield cover Trump's new massive giveaway to the rich, cuts for the poor. Plus, Israel sh---ing at diplomats, and much more!To get FREE help navigating Medicare and Medicare Advantage, call 757-349-8232 or go to AskChapter.org/Camp *Chapter: Chapter and its affiliates are not connected with or endorsed by any government entity or the federal Medicare program. Chapter Advisory, LLC represents Medicare Advantage HMO, PPO, and PFFS organizations and stand alone prescription drug plans that have a Medicare contract. Enrollment depends on the plan's contract renewal. While we have a database of every Medicare plan nationwide and can help you to search among all plans, we have contracts with many but not all plans. As a result, we do not offer every plan available in your area. Currently we represent 50 organizations which offer 18,160 products nationwide. We search and recommend all plans, even those we don't directly offer. You can contact a licensed Chapter agent to find out the number of products available in your specific area. Please contact Medicare.gov, 1-800-Medicare, or your local State Health Insurance Program (SHIP) to get information on all of your option. *Average potential savings are based on realized premium, co-pay, and out of pocket savings estimates self-reported by consumers that worked with Chapter Advisory LLC to enroll in a Medicare Supplement, Medicare Advantage, and/or Part D Prescription Drug Plan. The average is limited to consumers that chose to self-report. Savings information is subject to periodic updates and corrections. There is no guarantee of savings and any savings may vary by policy type, state, or other factors.

Lee Camp digs into Trump's admission that 300,000 Gazans have been killed, DOGE may be coming to an end, a social media star is mocked for speaking to the police, Biden has cancer, and Trump is working to crush the ICC. All that and more!To learn more about Chapter Medicare Advice, call 757-349-8232 or go to AskChapter.org/Camp *Chapter: Chapter and its affiliates are not connected with or endorsed by any government entity or the federal Medicare program. Chapter Advisory, LLC represents Medicare Advantage HMO, PPO, and PFFS organizations and stand alone prescription drug plans that have a Medicare contract. Enrollment depends on the plan's contract renewal. While we have a database of every Medicare plan nationwide and can help you to search among all plans, we have contracts with many but not all plans. As a result, we do not offer every plan available in your area. Currently we represent 50 organizations which offer 18,160 products nationwide. We search and recommend all plans, even those we don't directly offer. You can contact a licensed Chapter agent to find out the number of products available in your specific area. Please contact Medicare.gov, 1-800-Medicare, or your local State Health Insurance Program (SHIP) to get information on all of your option.*Average potential savings are based on realized premium, co-pay, and out of pocket savings estimates self-reported by consumers that worked with Chapter Advisory LLC to enroll in a Medicare Supplement, Medicare Advantage, and/or Part D Prescription Drug Plan. The average is limited to consumers that chose to self-report. Savings information is subject to periodic updates and corrections. There is no guarantee of savings and any savings may vary by policy type, state, or other factors.

Lee Camp digs into Trump's admission that 300,000 Gazans have been killed, DOGE may be coming to an end, a social media star is mocked for speaking to the police, Biden has cancer, and Trump is working to crush the ICC. All that and more!To learn more about Chapter Medicare Advice, call 757-349-8232 or go to AskChapter.org/Camp *Chapter: Chapter and its affiliates are not connected with or endorsed by any government entity or the federal Medicare program. Chapter Advisory, LLC represents Medicare Advantage HMO, PPO, and PFFS organizations and stand alone prescription drug plans that have a Medicare contract. Enrollment depends on the plan's contract renewal. While we have a database of every Medicare plan nationwide and can help you to search among all plans, we have contracts with many but not all plans. As a result, we do not offer every plan available in your area. Currently we represent 50 organizations which offer 18,160 products nationwide. We search and recommend all plans, even those we don't directly offer. You can contact a licensed Chapter agent to find out the number of products available in your specific area. Please contact Medicare.gov, 1-800-Medicare, or your local State Health Insurance Program (SHIP) to get information on all of your option.*Average potential savings are based on realized premium, co-pay, and out of pocket savings estimates self-reported by consumers that worked with Chapter Advisory LLC to enroll in a Medicare Supplement, Medicare Advantage, and/or Part D Prescription Drug Plan. The average is limited to consumers that chose to self-report. Savings information is subject to periodic updates and corrections. There is no guarantee of savings and any savings may vary by policy type, state, or other factors.

Lee Camp gets into the Liberal media going nuts over Pentagon firings AND RFK Jr. outing Trump and his $100 Million from Big Pharma PLUS the truth about Zelensky! To get FREE help navigating Medicare and Medicare Advantage, call 757-349-8232 or go to AskChapter.org/Camp *Chapter: Chapter and its affiliates are not connected with or endorsed by any government entity or the federal Medicare program. Chapter Advisory, LLC represents Medicare Advantage HMO, PPO, and PFFS organizations and stand alone prescription drug plans that have a Medicare contract. Enrollment depends on the plan's contract renewal. While we have a database of every Medicare plan nationwide and can help you to search among all plans, we have contracts with many but not all plans. As a result, we do not offer every plan available in your area. Currently we represent 50 organizations which offer 18,160 products nationwide. We search and recommend all plans, even those we don't directly offer. You can contact a licensed Chapter agent to find out the number of products available in your specific area. Please contact Medicare.gov, 1-800-Medicare, or your local State Health Insurance Program (SHIP) to get information on all of your option. *Average potential savings are based on realized premium, co-pay, and out of pocket savings estimates self-reported by consumers that worked with Chapter Advisory LLC to enroll in a Medicare Supplement, Medicare Advantage, and/or Part D Prescription Drug Plan. The average is limited to consumers that chose to self-report. Savings information is subject to periodic updates and corrections. There is no guarantee of savings and any savings may vary by policy type, state, or other factors.

Lee Camp gets into the Liberal media going nuts over Pentagon firings AND RFK Jr. outing Trump and his $100 Million from Big Pharma PLUS the truth about Zelensky! To get FREE help navigating Medicare and Medicare Advantage, call 757-349-8232 or go to AskChapter.org/Camp *Chapter: Chapter and its affiliates are not connected with or endorsed by any government entity or the federal Medicare program. Chapter Advisory, LLC represents Medicare Advantage HMO, PPO, and PFFS organizations and stand alone prescription drug plans that have a Medicare contract. Enrollment depends on the plan's contract renewal. While we have a database of every Medicare plan nationwide and can help you to search among all plans, we have contracts with many but not all plans. As a result, we do not offer every plan available in your area. Currently we represent 50 organizations which offer 18,160 products nationwide. We search and recommend all plans, even those we don't directly offer. You can contact a licensed Chapter agent to find out the number of products available in your specific area. Please contact Medicare.gov, 1-800-Medicare, or your local State Health Insurance Program (SHIP) to get information on all of your option. *Average potential savings are based on realized premium, co-pay, and out of pocket savings estimates self-reported by consumers that worked with Chapter Advisory LLC to enroll in a Medicare Supplement, Medicare Advantage, and/or Part D Prescription Drug Plan. The average is limited to consumers that chose to self-report. Savings information is subject to periodic updates and corrections. There is no guarantee of savings and any savings may vary by policy type, state, or other factors.

Lee covers the shocking deal between Trump and Hamas PLUS the many other ways Trump seems to be leaving Israel out of things. AND the shocking technological advancements in China that the US can't seem to stop. That and much more!To learn more about Chapter Medicare Advice, call 757-349-8232 or go to AskChapter.org/Camp *Chapter: Chapter and its affiliates are not connected with or endorsed by any government entity or the federal Medicare program. Chapter Advisory, LLC represents Medicare Advantage HMO, PPO, and PFFS organizations and stand alone prescription drug plans that have a Medicare contract. Enrollment depends on the plan's contract renewal. While we have a database of every Medicare plan nationwide and can help you to search among all plans, we have contracts with many but not all plans. As a result, we do not offer every plan available in your area. Currently we represent 50 organizations which offer 18,160 products nationwide. We search and recommend all plans, even those we don't directly offer. You can contact a licensed Chapter agent to find out the number of products available in your specific area. Please contact Medicare.gov, 1-800-Medicare, or your local State Health Insurance Program (SHIP) to get information on all of your option.*Average potential savings are based on realized premium, co-pay, and out of pocket savings estimates self-reported by consumers that worked with Chapter Advisory LLC to enroll in a Medicare Supplement, Medicare Advantage, and/or Part D Prescription Drug Plan. The average is limited to consumers that chose to self-report. Savings information is subject to periodic updates and corrections. There is no guarantee of savings and any savings may vary by policy type, state, or other factors.

Lee covers the shocking deal between Trump and Hamas PLUS the many other ways Trump seems to be leaving Israel out of things. AND the shocking technological advancements in China that the US can't seem to stop. That and much more!To learn more about Chapter Medicare Advice, call 757-349-8232 or go to AskChapter.org/Camp *Chapter: Chapter and its affiliates are not connected with or endorsed by any government entity or the federal Medicare program. Chapter Advisory, LLC represents Medicare Advantage HMO, PPO, and PFFS organizations and stand alone prescription drug plans that have a Medicare contract. Enrollment depends on the plan's contract renewal. While we have a database of every Medicare plan nationwide and can help you to search among all plans, we have contracts with many but not all plans. As a result, we do not offer every plan available in your area. Currently we represent 50 organizations which offer 18,160 products nationwide. We search and recommend all plans, even those we don't directly offer. You can contact a licensed Chapter agent to find out the number of products available in your specific area. Please contact Medicare.gov, 1-800-Medicare, or your local State Health Insurance Program (SHIP) to get information on all of your option.*Average potential savings are based on realized premium, co-pay, and out of pocket savings estimates self-reported by consumers that worked with Chapter Advisory LLC to enroll in a Medicare Supplement, Medicare Advantage, and/or Part D Prescription Drug Plan. The average is limited to consumers that chose to self-report. Savings information is subject to periodic updates and corrections. There is no guarantee of savings and any savings may vary by policy type, state, or other factors.

Lee gets into the attack on Israel's airport that is turning Israel into a no-fly zone. Plus, why both India and Pakistan want war. AND much more!Lee Camp livestreams 3 days a week, and Unredacted Tonight comes out on Thursdays at 7pm ET. Make sure you don't miss an episode!Today's Sponsor: To get FREE help navigating Medicare and Medicare Advantage, call 757-349-8232 or go to AskChapter.org/Camp*Chapter: Chapter and its affiliates are not connected with or endorsed by any government entity or the federal Medicare program. Chapter Advisory, LLC represents Medicare Advantage HMO, PPO, and PFFS organizations and standalone prescription drug plans that have a Medicare contract. Enrollment depends on the plan's contract renewal. While we have a database of every Medicare plan nationwide and can help you to search among all plans, we have contracts with many but not all plans. As a result, we do not offer every plan available in your area. Currently, we represent 50 organizations which offer 18,160 products nationwide. We search and recommend all plans, even those we don't directly offer. You can contact a licensed Chapter agent to find out the number of products available in your specific area. Please contact Medicare.gov, 1-800-Medicare, or your local State Health Insurance Program (SHIP) to get information on all of your option.*Average potential savings are based on realized premium, co-pay, and out of pocket savings estimates self-reported by consumers that worked with Chapter Advisory LLC to enroll in a Medicare Supplement, Medicare Advantage, and/or Part D Prescription Drug Plan. The average is limited to consumers that chose to self-report. Savings information is subject to periodic updates and corrections. There is no guarantee of savings and any savings may vary by policy type, state, or other factors.

Lee gets into the attack on Israel's airport that is turning Israel into a no-fly zone. Plus, why both India and Pakistan want war. AND much more!Lee Camp livestreams 3 days a week, and Unredacted Tonight comes out on Thursdays at 7pm ET. Make sure you don't miss an episode!Today's Sponsor: To get FREE help navigating Medicare and Medicare Advantage, call 757-349-8232 or go to AskChapter.org/Camp*Chapter: Chapter and its affiliates are not connected with or endorsed by any government entity or the federal Medicare program. Chapter Advisory, LLC represents Medicare Advantage HMO, PPO, and PFFS organizations and standalone prescription drug plans that have a Medicare contract. Enrollment depends on the plan's contract renewal. While we have a database of every Medicare plan nationwide and can help you to search among all plans, we have contracts with many but not all plans. As a result, we do not offer every plan available in your area. Currently, we represent 50 organizations which offer 18,160 products nationwide. We search and recommend all plans, even those we don't directly offer. You can contact a licensed Chapter agent to find out the number of products available in your specific area. Please contact Medicare.gov, 1-800-Medicare, or your local State Health Insurance Program (SHIP) to get information on all of your option.*Average potential savings are based on realized premium, co-pay, and out of pocket savings estimates self-reported by consumers that worked with Chapter Advisory LLC to enroll in a Medicare Supplement, Medicare Advantage, and/or Part D Prescription Drug Plan. The average is limited to consumers that chose to self-report. Savings information is subject to periodic updates and corrections. There is no guarantee of savings and any savings may vary by policy type, state, or other factors.

Lee Camp & Eleanor Goldfield reveal the truth behind Trump's new UNHINGED federal budget PLUS India's attack on Pakistan, the police again go after Columbia students, and US contractors being used WHERE?! All that and more!To get FREE help to navigate Medicare and Medicare Advantage, call 757-349-8232 or go to AskChapter.org/Camp*Chapter: Chapter and its affiliates are not connected with or endorsed by any government entity or the federal Medicare program. Chapter Advisory, LLC represents Medicare Advantage HMO, PPO, and PFFS organizations and standalone prescription drug plans that have a Medicare contract. Enrollment depends on the plan's contract renewal. While we have a database of every Medicare plan nationwide and can help you to search among all plans, we have contracts with many but not all plans. As a result, we do not offer every plan available in your area. Currently, we represent 50 organizations which offer 18,160 products nationwide. We search and recommend all plans, even those we don't directly offer. You can contact a licensed Chapter agent to find out the number of products available in your specific area. Please contact Medicare.gov, 1-800-Medicare, or your local State Health Insurance Program (SHIP) to get information on all of your option.*Average potential savings are based on realized premium, co-pay, and out of pocket savings estimates self-reported by consumers that worked with Chapter Advisory LLC to enroll in a Medicare Supplement, Medicare Advantage, and/or Part D Prescription Drug Plan. The average is limited to consumers that chose to self-report. Savings information is subject to periodic updates and corrections. There is no guarantee of savings and any savings may vary by policy type, state, or other factors.

Lee Camp & Eleanor Goldfield reveal the truth behind Trump's new UNHINGED federal budget PLUS India's attack on Pakistan, the police again go after Columbia students, and US contractors being used WHERE?! All that and more!To get FREE help to navigate Medicare and Medicare Advantage, call 757-349-8232 or go to AskChapter.org/Camp*Chapter: Chapter and its affiliates are not connected with or endorsed by any government entity or the federal Medicare program. Chapter Advisory, LLC represents Medicare Advantage HMO, PPO, and PFFS organizations and standalone prescription drug plans that have a Medicare contract. Enrollment depends on the plan's contract renewal. While we have a database of every Medicare plan nationwide and can help you to search among all plans, we have contracts with many but not all plans. As a result, we do not offer every plan available in your area. Currently, we represent 50 organizations which offer 18,160 products nationwide. We search and recommend all plans, even those we don't directly offer. You can contact a licensed Chapter agent to find out the number of products available in your specific area. Please contact Medicare.gov, 1-800-Medicare, or your local State Health Insurance Program (SHIP) to get information on all of your option.*Average potential savings are based on realized premium, co-pay, and out of pocket savings estimates self-reported by consumers that worked with Chapter Advisory LLC to enroll in a Medicare Supplement, Medicare Advantage, and/or Part D Prescription Drug Plan. The average is limited to consumers that chose to self-report. Savings information is subject to periodic updates and corrections. There is no guarantee of savings and any savings may vary by policy type, state, or other factors.

Lee Camp digs into the hidden side of the day's news. Israel is on fire for a hidden reason. Trump wants to reopen Alcatraz, and here's why that's insane. Plus much more!To get FREE help to navigate Medicare and Medicare Advantage, call 757-349-8232 or go to AskChapter.org/Camp*Chapter: Chapter and its affiliates are not connected with or endorsed by any government entity or the federal Medicare program. Chapter Advisory, LLC represents Medicare Advantage HMO, PPO, and PFFS organizations and stand alone prescription drug plans that have a Medicare contract. Enrollment depends on the plan's contract renewal. While we have a database of every Medicare plan nationwide and can help you to search among all plans, we have contracts with many but not all plans. As a result, we do not offer every plan available in your area. Currently, we represent 50 organizations which offer 18,160 products nationwide. We search and recommend all plans, even those we don't directly offer. You can contact a licensed Chapter agent to find out the number of products available in your specific area. Please contact Medicare.gov, 1-800-Medicare, or your local State Health Insurance Program (SHIP) to get information on all of your option.*Average potential savings are based on realized premium, co-pay, and out of pocket savings estimates self-reported by consumers that worked with Chapter Advisory LLC to enroll in a Medicare Supplement, Medicare Advantage, and/or Part D Prescription Drug Plan. The average is limited to consumers that chose to self-report. Savings information is subject to periodic updates and corrections. There is no guarantee of savings and any savings may vary by policy type, state, or other factors.

Lee Camp digs into the hidden side of the day's news. Israel is on fire for a hidden reason. Trump wants to reopen Alcatraz, and here's why that's insane. Plus much more!To get FREE help to navigate Medicare and Medicare Advantage, call 757-349-8232 or go to AskChapter.org/Camp*Chapter: Chapter and its affiliates are not connected with or endorsed by any government entity or the federal Medicare program. Chapter Advisory, LLC represents Medicare Advantage HMO, PPO, and PFFS organizations and stand alone prescription drug plans that have a Medicare contract. Enrollment depends on the plan's contract renewal. While we have a database of every Medicare plan nationwide and can help you to search among all plans, we have contracts with many but not all plans. As a result, we do not offer every plan available in your area. Currently, we represent 50 organizations which offer 18,160 products nationwide. We search and recommend all plans, even those we don't directly offer. You can contact a licensed Chapter agent to find out the number of products available in your specific area. Please contact Medicare.gov, 1-800-Medicare, or your local State Health Insurance Program (SHIP) to get information on all of your option.*Average potential savings are based on realized premium, co-pay, and out of pocket savings estimates self-reported by consumers that worked with Chapter Advisory LLC to enroll in a Medicare Supplement, Medicare Advantage, and/or Part D Prescription Drug Plan. The average is limited to consumers that chose to self-report. Savings information is subject to periodic updates and corrections. There is no guarantee of savings and any savings may vary by policy type, state, or other factors.

Paul Castner started out his path in the insurance industry by working at one of the Nation's Top Medicare carriers. He began in the broker services department, under strong leadership who encouraged him to always pursue learning and trusting his skill set. From there he joined their sales team and had some of the best in class mentors along the way who not only strengthened his knowledge of the insurance products but also the importance it was to the population it served. C & K Healthcare Advisors was developed by Paul Castner and Mike Killmeyer based out of Pittsburgh Pennsylvania, with the concept of giving back to the generations that have came before them. What started out as an agency that only serviced Pennsylvania, Ohio, and West Virginia rapidly grew to now servicing the entire United States. Our agents live and work in your communities and we strive to be the face of comfort and trust. Our pledge to you is that we will always do our best to inform you of the options that fit your needs, lifestyle, and budget, while working ethically and doing what is morally right.Discover the peace of mind that comes with Paul Castner and his team of licensed consultants expert guidance—because you've earned a retirement that's as fulfilling as it is secure. Call them today or visit their website at https://www.ckhealthcareadvisors.com/C & K Healthcare Advisors, LLC and their agents are licensed and certified representatives of a Medicare Advantage (HMO, PPO and PFFS) organization and a stand-alone prescription drug plan with a Medicare contract. C & K Healthcare Advisors and their agents are not affiliated with the United States Government or the Federal Medicare Program. Enrollment in any plan depends on contract renewal. Medicare is available to some individuals under the age of 65 in limited circumstances. Plans and products may not be available in all areas. Certain exclusions and limitations may apply. We do not offer every plan available in your area. Any information we provide is limited to those plans we do offer in your area. Please contact Medicare.gov or 1–800 MEDICARE to get information on all of your options.Influential Entrepreneurs with Mike Saundershttps://businessinnovatorsradio.com/influential-entrepreneurs-with-mike-saunders/Source: https://businessinnovatorsradio.com/interview-with-paul-castner-president-of-c-k-healthcare-advisors-discussing-niche-markets

Paul Castner started out his path in the insurance industry by working at one of the Nation's Top Medicare carriers. He began in the broker services department, under strong leadership who encouraged him to always pursue learning and trusting his skill set. From there he joined their sales team and had some of the best in class mentors along the way who not only strengthened his knowledge of the insurance products but also the importance it was to the population it served. C & K Healthcare Advisors was developed by Paul Castner and Mike Killmeyer based out of Pittsburgh Pennsylvania, with the concept of giving back to the generations that have came before them. What started out as an agency that only serviced Pennsylvania, Ohio, and West Virginia rapidly grew to now servicing the entire United States. Our agents live and work in your communities and we strive to be the face of comfort and trust. Our pledge to you is that we will always do our best to inform you of the options that fit your needs, lifestyle, and budget, while working ethically and doing what is morally right.Discover the peace of mind that comes with Paul Castner and his team of licensed consultants expert guidance—because you've earned a retirement that's as fulfilling as it is secure. Call them today or visit their website at https://www.ckhealthcareadvisors.com/C & K Healthcare Advisors, LLC and their agents are licensed and certified representatives of a Medicare Advantage (HMO, PPO and PFFS) organization and a stand-alone prescription drug plan with a Medicare contract. C & K Healthcare Advisors and their agents are not affiliated with the United States Government or the Federal Medicare Program. Enrollment in any plan depends on contract renewal. Medicare is available to some individuals under the age of 65 in limited circumstances. Plans and products may not be available in all areas. Certain exclusions and limitations may apply. We do not offer every plan available in your area. Any information we provide is limited to those plans we do offer in your area. Please contact Medicare.gov or 1–800 MEDICARE to get information on all of your options.Influential Entrepreneurs with Mike Saundershttps://businessinnovatorsradio.com/influential-entrepreneurs-with-mike-saunders/Source: https://businessinnovatorsradio.com/interview-with-paul-castner-president-of-c-k-healthcare-advisors-discussing-advice-for-financial-professionals-to-choose-marketing-mentors

Paul Castner started out his path in the insurance industry by working at one of the Nation's Top Medicare carriers. He began in the broker services department, under strong leadership who encouraged him to always pursue learning and trusting his skill set. From there he joined their sales team and had some of the best in class mentors along the way who not only strengthened his knowledge of the insurance products but also the importance it was to the population it served. C & K Healthcare Advisors was developed by Paul Castner and Mike Killmeyer based out of Pittsburgh Pennsylvania, with the concept of giving back to the generations that have came before them. What started out as an agency that only serviced Pennsylvania, Ohio, and West Virginia rapidly grew to now servicing the entire United States. Our agents live and work in your communities and we strive to be the face of comfort and trust. Our pledge to you is that we will always do our best to inform you of the options that fit your needs, lifestyle, and budget, while working ethically and doing what is morally right.Discover the peace of mind that comes with Paul Castner and his team of licensed consultants expert guidance—because you've earned a retirement that's as fulfilling as it is secure. Call them today or visit their website at https://www.ckhealthcareadvisors.com/C & K Healthcare Advisors, LLC and their agents are licensed and certified representatives of a Medicare Advantage (HMO, PPO and PFFS) organization and a stand-alone prescription drug plan with a Medicare contract. C & K Healthcare Advisors and their agents are not affiliated with the United States Government or the Federal Medicare Program. Enrollment in any plan depends on contract renewal. Medicare is available to some individuals under the age of 65 in limited circumstances. Plans and products may not be available in all areas. Certain exclusions and limitations may apply. We do not offer every plan available in your area. Any information we provide is limited to those plans we do offer in your area. Please contact Medicare.gov or 1–800 MEDICARE to get information on all of your options.Influential Entrepreneurs with Mike Saundershttps://businessinnovatorsradio.com/influential-entrepreneurs-with-mike-saunders/Source: https://businessinnovatorsradio.com/interview-with-paul-castner-president-of-c-k-healthcare-advisors-discussing-niche-markets

Paul Castner started out his path in the insurance industry by working at one of the Nation's Top Medicare carriers. He began in the broker services department, under strong leadership who encouraged him to always pursue learning and trusting his skill set. From there he joined their sales team and had some of the best in class mentors along the way who not only strengthened his knowledge of the insurance products but also the importance it was to the population it served. C & K Healthcare Advisors was developed by Paul Castner and Mike Killmeyer based out of Pittsburgh Pennsylvania, with the concept of giving back to the generations that have came before them. What started out as an agency that only serviced Pennsylvania, Ohio, and West Virginia rapidly grew to now servicing the entire United States. Our agents live and work in your communities and we strive to be the face of comfort and trust. Our pledge to you is that we will always do our best to inform you of the options that fit your needs, lifestyle, and budget, while working ethically and doing what is morally right.Discover the peace of mind that comes with Paul Castner and his team of licensed consultants expert guidance—because you've earned a retirement that's as fulfilling as it is secure. Call them today or visit their website at https://www.ckhealthcareadvisors.com/C & K Healthcare Advisors, LLC and their agents are licensed and certified representatives of a Medicare Advantage (HMO, PPO and PFFS) organization and a stand-alone prescription drug plan with a Medicare contract. C & K Healthcare Advisors and their agents are not affiliated with the United States Government or the Federal Medicare Program. Enrollment in any plan depends on contract renewal. Medicare is available to some individuals under the age of 65 in limited circumstances. Plans and products may not be available in all areas. Certain exclusions and limitations may apply. We do not offer every plan available in your area. Any information we provide is limited to those plans we do offer in your area. Please contact Medicare.gov or 1–800 MEDICARE to get information on all of your options.Influential Entrepreneurs with Mike Saundershttps://businessinnovatorsradio.com/influential-entrepreneurs-with-mike-saunders/Source: https://businessinnovatorsradio.com/interview-with-paul-castner-president-of-c-k-healthcare-advisors-discussing-advice-for-financial-professionals-to-choose-marketing-mentors

Paul Castner started out his path in the insurance industry by working at one of the Nation's Top Medicare carriers. He began in the broker services department, under strong leadership who encouraged him to always pursue learning and trusting his skill set. From there he joined their sales team and had some of the best in class mentors along the way who not only strengthened his knowledge of the insurance products but also the importance it was to the population it served. C & K Healthcare Advisors was developed by Paul Castner and Mike Killmeyer based out of Pittsburgh Pennsylvania, with the concept of giving back to the generations that have come before them. What started out as an agency that only serviced Pennsylvania, Ohio, and West Virginia rapidly grew to now servicing the entire United States. Our agents live and work in your communities and we strive to be the face of comfort and trust. Our pledge to you is that we will always do our best to inform you of the options that fit your needs, lifestyle, and budget while working ethically and doing what is morally right.Discover the peace of mind that comes with Paul Castner and his team of licensed consultants' expert guidance—because you've earned a retirement that's as fulfilling as it is secure. Call them today or visit their website at https://www.ckhealthcareadvisors.com/C & K Healthcare Advisors, LLC and their agents are licensed and certified representatives of a Medicare Advantage (HMO, PPO, and PFFS) organization and a stand-alone prescription drug plan with a Medicare contract.C & K Healthcare Advisors and their agents are not affiliated with the United States Government or the Federal Medicare Program. Enrollment in any plan depends on contract renewal. Medicare is available to some individuals under the age of 65 in limited circumstances. Plans and products may not be available in all areas. Certain exclusions and limitations may apply. We do not offer every plan available in your area. Any information we provide is limited to those plans we do offer in your area. Please contact Medicare.gov or 1–800 MEDICARE to get information on all of your options.Influential Entrepreneurs with Mike Saundershttps://businessinnovatorsradio.com/influential-entrepreneurs-with-mike-saunders/Source: https://businessinnovatorsradio.com/interview-with-paul-castner-president-of-c-k-healthcare-advisors-discussing-life-insurance

Paul Castner started out his path in the insurance industry by working at one of the Nation's Top Medicare carriers. He began in the broker services department, under strong leadership who encouraged him to always pursue learning and trusting his skill set. From there he joined their sales team and had some of the best in class mentors along the way who not only strengthened his knowledge of the insurance products but also the importance it was to the population it served. C & K Healthcare Advisors was developed by Paul Castner and Mike Killmeyer based out of Pittsburgh Pennsylvania, with the concept of giving back to the generations that have come before them. What started out as an agency that only serviced Pennsylvania, Ohio, and West Virginia rapidly grew to now servicing the entire United States. Our agents live and work in your communities and we strive to be the face of comfort and trust. Our pledge to you is that we will always do our best to inform you of the options that fit your needs, lifestyle, and budget while working ethically and doing what is morally right.Discover the peace of mind that comes with Paul Castner and his team of licensed consultants' expert guidance—because you've earned a retirement that's as fulfilling as it is secure. Call them today or visit their website at https://www.ckhealthcareadvisors.com/C & K Healthcare Advisors, LLC and their agents are licensed and certified representatives of a Medicare Advantage (HMO, PPO, and PFFS) organization and a stand-alone prescription drug plan with a Medicare contract.C & K Healthcare Advisors and their agents are not affiliated with the United States Government or the Federal Medicare Program. Enrollment in any plan depends on contract renewal. Medicare is available to some individuals under the age of 65 in limited circumstances. Plans and products may not be available in all areas. Certain exclusions and limitations may apply. We do not offer every plan available in your area. Any information we provide is limited to those plans we do offer in your area. Please contact Medicare.gov or 1–800 MEDICARE to get information on all of your options.Influential Entrepreneurs with Mike Saundershttps://businessinnovatorsradio.com/influential-entrepreneurs-with-mike-saunders/Source: https://businessinnovatorsradio.com/interview-with-paul-castner-president-of-c-k-healthcare-advisors-discussing-life-insurance

Paul Castner started out his path in the insurance industry by working at one of the Nation's Top Medicare carriers. He began in the broker services department, under strong leadership who encouraged him to always pursue learning and trusting his skill set. From there he joined their sales team and had some of the best in class mentors along the way who not only strengthened his knowledge of the insurance products but also the importance it was to the population it served. C & K Healthcare Advisors was developed by Paul Castner and Mike Killmeyer based out of Pittsburgh Pennsylvania, with the concept of giving back to the generations that have came before them. What started out as an agency that only serviced Pennsylvania, Ohio, and West Virginia rapidly grew to now servicing the entire United States. Our agents live and work in your communities and we strive to be the face of comfort and trust. Our pledge to you is that we will always do our best to inform you of the options that fit your needs, lifestyle, and budget, while working ethically and doing what is morally right.Discover the peace of mind that comes with Paul Castner and his team of licensed consultants expert guidance—because you've earned a retirement that's as fulfilling as it is secure. Call them today or visit their website at https://www.ckhealthcareadvisors.com/C & K Healthcare Advisors, LLC and their agents are licensed and certified representatives of a Medicare Advantage (HMO, PPO and PFFS) organization and a stand-alone prescription drug plan with a Medicare contract.C & K Healthcare Advisors and their agents are not affiliated with the United States Government or the Federal Medicare Program. Enrollment in any plan depends on contract renewal. Medicare is available to some individuals under the age of 65 in limited circumstances. Plans and products may not be available in all areas. Certain exclusions and limitations may apply. We do not offer every plan available in your area. Any information we provide is limited to those plans we do offer in your area. Please contact Medicare.gov or 1–800 MEDICARE to get information on all of your options.Influential Entrepreneurs with Mike Saundershttps://businessinnovatorsradio.com/influential-entrepreneurs-with-mike-saunders/Source: https://businessinnovatorsradio.com/interview-with-paul-castner-president-of-c-k-healthcare-advisors-discussing-retirement-planning

Paul Castner started out his path in the insurance industry by working at one of the Nation's Top Medicare carriers. He began in the broker services department, under strong leadership who encouraged him to always pursue learning and trusting his skill set. From there he joined their sales team and had some of the best in class mentors along the way who not only strengthened his knowledge of the insurance products but also the importance it was to the population it served. C & K Healthcare Advisors was developed by Paul Castner and Mike Killmeyer based out of Pittsburgh Pennsylvania, with the concept of giving back to the generations that have came before them. What started out as an agency that only serviced Pennsylvania, Ohio, and West Virginia rapidly grew to now servicing the entire United States. Our agents live and work in your communities and we strive to be the face of comfort and trust. Our pledge to you is that we will always do our best to inform you of the options that fit your needs, lifestyle, and budget, while working ethically and doing what is morally right.Discover the peace of mind that comes with Paul Castner and his team of licensed consultants expert guidance—because you've earned a retirement that's as fulfilling as it is secure. Call them today or visit their website at https://www.ckhealthcareadvisors.com/C & K Healthcare Advisors, LLC and their agents are licensed and certified representatives of a Medicare Advantage (HMO, PPO and PFFS) organization and a stand-alone prescription drug plan with a Medicare contract.C & K Healthcare Advisors and their agents are not affiliated with the United States Government or the Federal Medicare Program. Enrollment in any plan depends on contract renewal. Medicare is available to some individuals under the age of 65 in limited circumstances. Plans and products may not be available in all areas. Certain exclusions and limitations may apply. We do not offer every plan available in your area. Any information we provide is limited to those plans we do offer in your area. Please contact Medicare.gov or 1–800 MEDICARE to get information on all of your options.Influential Entrepreneurs with Mike Saundershttps://businessinnovatorsradio.com/influential-entrepreneurs-with-mike-saunders/Source: https://businessinnovatorsradio.com/interview-with-paul-castner-president-of-c-k-healthcare-advisors-discussing-retirement-planning

Paul Castner started out his path in the insurance industry by working at one of the Nation's Top Medicare carriers. He began in the broker services department, under strong leadership who encouraged him to always pursue learning and trusting his skill set. From there he joined their sales team and had some of the best in class mentors along the way who not only strengthened his knowledge of the insurance products but also the importance it was to the population it served. C & K Healthcare Advisors was developed by Paul Castner and Mike Killmeyer based out of Pittsburgh Pennsylvania, with the concept of giving back to the generations that have came before them. What started out as an agency that only serviced Pennsylvania, Ohio, and West Virginia rapidly grew to now servicing the entire United States. Our agents live and work in your communities and we strive to be the face of comfort and trust. Our pledge to you is that we will always do our best to inform you of the options that fit your needs, lifestyle, and budget, while working ethically and doing what is morally right.Discover the peace of mind that comes with Paul Castner and his team of licensed consultants expert guidance—because you've earned a retirement that's as fulfilling as it is secure.Call them today or visit their website at https://www.ckhealthcareadvisors.com/C & K Healthcare Advisors, LLC and their agents are licensed and certified representatives of a Medicare Advantage (HMO, PPO and PFFS) organization and a stand-alone prescription drug plan with a Medicare contract. C & K Healthcare Advisors and their agents are not affiliated with the United States Government or the Federal Medicare Program. Enrollment in any plan depends on contract renewal. Medicare is available to some individuals under the age of 65 in limited circumstances. Plans and products may not be available in all areas. Certain exclusions and limitations may apply. We do not offer every plan available in your area. Any information we provide is limited to those plans we do offer in your area. Please contact Medicare.gov or 1–800 MEDICARE to get information on all of your options.Influential Entrepreneurs with Mike Saundershttps://businessinnovatorsradio.com/influential-entrepreneurs-with-mike-saunders/Source: https://businessinnovatorsradio.com/interview-with-paul-castner-president-of-c-k-healthcare-advisors-discussing-medicare

Paul Castner started out his path in the insurance industry by working at one of the Nation's Top Medicare carriers. He began in the broker services department, under strong leadership who encouraged him to always pursue learning and trusting his skill set. From there he joined their sales team and had some of the best in class mentors along the way who not only strengthened his knowledge of the insurance products but also the importance it was to the population it served. C & K Healthcare Advisors was developed by Paul Castner and Mike Killmeyer based out of Pittsburgh Pennsylvania, with the concept of giving back to the generations that have came before them. What started out as an agency that only serviced Pennsylvania, Ohio, and West Virginia rapidly grew to now servicing the entire United States. Our agents live and work in your communities and we strive to be the face of comfort and trust. Our pledge to you is that we will always do our best to inform you of the options that fit your needs, lifestyle, and budget, while working ethically and doing what is morally right.Discover the peace of mind that comes with Paul Castner and his team of licensed consultants expert guidance—because you've earned a retirement that's as fulfilling as it is secure.Call them today or visit their website at https://www.ckhealthcareadvisors.com/C & K Healthcare Advisors, LLC and their agents are licensed and certified representatives of a Medicare Advantage (HMO, PPO and PFFS) organization and a stand-alone prescription drug plan with a Medicare contract. C & K Healthcare Advisors and their agents are not affiliated with the United States Government or the Federal Medicare Program. Enrollment in any plan depends on contract renewal. Medicare is available to some individuals under the age of 65 in limited circumstances. Plans and products may not be available in all areas. Certain exclusions and limitations may apply. We do not offer every plan available in your area. Any information we provide is limited to those plans we do offer in your area. Please contact Medicare.gov or 1–800 MEDICARE to get information on all of your options.Influential Entrepreneurs with Mike Saundershttps://businessinnovatorsradio.com/influential-entrepreneurs-with-mike-saunders/Source: https://businessinnovatorsradio.com/interview-with-paul-castner-president-of-c-k-healthcare-advisors-discussing-medicare

News and notes, mostly about our Rams. We push back on PFFs inside linebacker rankings on behalf of our own Ernest Jones. And how about Episode 2 of Behind the Grind! Great insight in to the Rams 2024 draft, from the area scouts down to how those first few rounds unfolded. Learn more about your ad choices. Visit megaphone.fm/adchoices

In todays episode of Bleav in Bears your host Sky Ditka Kruse is joined by PFFs very own Trevor Sikkema! Sky and Trevor go over the Bears 2024 draft class, realistic expectations on Caleb Williams and Rome Odunze, is the jump from the Ivy league to the NFL gonna be too much for Kiran Amegadjie? was a 4th round too early for the legend of the crocodile punter Tory Taylor? and can Austin Booker develop into a starter opposite of Montez Sweat? Tune in and find out now!

The boys are joined by PFFs own Draft expert Trevor Sikkema to discuss the Free Agency Moves, Caleb Williams to DC, and Draft Prospects that he loves. Then they answer fan questions to wrap up the episode!!Support the show

Brett Whitefield (@BGWhitefield) brings in Brad Spielberger (@PFF_Brad) to talk free agency and some of the big names that could influence the top of the draft. --- Support this podcast: https://podcasters.spotify.com/pod/show/fantasy-points-podcast/support

PFF's Trevor Sikkema joins us as we preview the Bucs x Eagles Wildcard matchup, updated and discuss the health of Jalen Hurts, Baker Mayfield's ribs, and how the Bucs CAN shock the world come Monday night!

In the third hour of Thursday's BBMS, the guys discuss the proper way to return gifts in "The Commish's Baltimore", debate whether or not there's another phenom out there like Victor Wembanyama, preview Ravens vs Browns with PFF's Gordon McGuinness, and take a trip to the World of Stupid.

The boys are joined by Nick Akridge from Pro Football Focus to try and make sense of the 14-7 loss to the Giants, get PFFs ratings for Players, and Sam Howells performance. Then they answer fan questions and give out Game Beers & Chores!!Support the show

We do our weekly bounce back fall back. We look at PFFs rankings. We go down on the farm.

While much of the attention has been on the same few transfers there are a handful of guys that should have an opportunity to have an impact for the Buffs in 2023. That is why I highlight a few from offense and defense that deserved to be discussed more, and may end up shocking some Colorado fans in the upcoming season. 9:17 Many people have being curious where Colorado's brand new roster ranks among other Pac-12 teams in terms of production. I break down PFFs' output rankings and where Colorado finds themselves amongst the entire Pac-12. I also dive into the fact that with all of the new faces that Colorado can still surprise people, they just have a tougher hill to climb. 13:53 The Pac-12's realignment and media rights deal issues have been well documented, but they don't affect them. I break down a recent report that highlights how important the success or lack of success that the Pac-12 has will be to the landscape of college football. Some conferences need the Pac-12 to find success so that way they can possibly have an avenue for more money and for survival, while others are likely hoping that the conference falls apart so they can poach some programs. 0:00 Which Buffs do you need to know 9:17 PFF rankings 13:53 Realignment woes and worries Read Colorado on Athlon: https://athlonsports.com/college-foot... Follow on Twitter: @Kevin__Borba and Follow the show on Twitter:@LockedOnBuffs 0:00 Which Buffs are Stars 8:00 Who could lose their job 15:00 Deion Sanders health update Support Us By Supporting Our Sponsors! Birddogs Go to birddogs.com/lockedoncollege and they'll throw in a free custom birddogs Yeti-style tumbler with every order. FanDuel Make Every Moment More. Don't miss the chance to get your No Sweat First Bet up to ONE THOUSAND DOLLARS in Bonus Bets when you go FanDuel.com/LOCKEDON. FANDUEL DISCLAIMER: 21+ in select states. First online real money wager only. Bonus issued as nonwithdrawable free bets that expires in 14 days. Restrictions apply. See terms at sportsbook.fanduel.com. Gambling Problem? Call 1-800-GAMBLER or visit FanDuel.com/RG (CO, IA, MD, MI, NJ, PA, IL, VA, WV), 1-800-NEXT-STEP or text NEXTSTEP to 53342 (AZ), 1-888-789-7777 or visit ccpg.org/chat (CT), 1-800-9-WITH-IT (IN), 1-800-522-4700 (WY, KS) or visit ksgamblinghelp.com (KS), 1-877-770-STOP (LA), 1-877-8-HOPENY or text HOPENY (467369) (NY), TN REDLINE 1-800-889-9789 (TN) Learn more about your ad choices. Visit podcastchoices.com/adchoices

While much of the attention has been on the same few transfers there are a handful of guys that should have an opportunity to have an impact for the Buffs in 2023. That is why I highlight a few from offense and defense that deserved to be discussed more, and may end up shocking some Colorado fans in the upcoming season.9:17 Many people have being curious where Colorado's brand new roster ranks among other Pac-12 teams in terms of production. I break down PFFs' output rankings and where Colorado finds themselves amongst the entire Pac-12. I also dive into the fact that with all of the new faces that Colorado can still surprise people, they just have a tougher hill to climb.13:53 The Pac-12's realignment and media rights deal issues have been well documented, but they don't affect them. I break down a recent report that highlights how important the success or lack of success that the Pac-12 has will be to the landscape of college football. Some conferences need the Pac-12 to find success so that way they can possibly have an avenue for more money and for survival, while others are likely hoping that the conference falls apart so they can poach some programs.0:00 Which Buffs do you need to know9:17 PFF rankings13:53 Realignment woes and worriesRead Colorado on Athlon: https://athlonsports.com/college-foot...Follow on Twitter: @Kevin__Borba and Follow the show on Twitter:@LockedOnBuffs0:00 Which Buffs are Stars8:00 Who could lose their job15:00 Deion Sanders health updateSupport Us By Supporting Our Sponsors!BirddogsGo to birddogs.com/lockedoncollege and they'll throw in a free custom birddogs Yeti-style tumbler with every order.FanDuelMake Every Moment More. Don't miss the chance to get your No Sweat First Bet up to ONE THOUSAND DOLLARS in Bonus Bets when you go FanDuel.com/LOCKEDON.FANDUEL DISCLAIMER: 21+ in select states. First online real money wager only. Bonus issued as nonwithdrawable free bets that expires in 14 days. Restrictions apply. See terms at sportsbook.fanduel.com. Gambling Problem? Call 1-800-GAMBLER or visit FanDuel.com/RG (CO, IA, MD, MI, NJ, PA, IL, VA, WV), 1-800-NEXT-STEP or text NEXTSTEP to 53342 (AZ), 1-888-789-7777 or visit ccpg.org/chat (CT), 1-800-9-WITH-IT (IN), 1-800-522-4700 (WY, KS) or visit ksgamblinghelp.com (KS), 1-877-770-STOP (LA), 1-877-8-HOPENY or text HOPENY (467369) (NY), TN REDLINE 1-800-889-9789 (TN) Learn more about your ad choices. Visit podcastchoices.com/adchoices

Happy Monday everyone! In the first hour the gang talked about the PFFs top-5 wide receiving room in the NFL, Alex Gold's $30,000 jello-shots at the College Baseball World Series, Jordan Lyles won his first game against the best team in baseball, Antonio Brown spoke on Tyreek Hill's podcast, and 'Kickin it wit Kramer'     #KansasCityRoyals #CWS #Florida #LSU #AntonioBrown #TyreekHill #PFF #PatrickMahomes #RaysBaseball

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.06.21.545967v1?rss=1 Authors: Boyd, S. L., Kuhn, N. C., Patterson, J. R., Stoll, A. C., Zimmerman, S. A., Kolanowski, M. R., Neubecker, J. J., Luk, K. C., Ramsson, E. S., Sortwell, C. E., Bernstein, A. I. Abstract: Parkinson's disease (PD) is the most common movement disorder and one of the fastest-growing neurological diseases worldwide. This increase outpaces the rate of aging and is most rapid in recently industrialized areas, suggesting the role of environmental factors. Consistent with this, epidemiological studies show an association between exposure to persistent organic pollutants and an increased risk of PD. When combined with post-mortem analysis and mechanistic studies, a role for specific compounds, including the organochlorine pesticide dieldrin, emerges. In mouse models, developmental dieldrin exposure causes male-specific exacerbation of neuronal susceptibility to MPTP and synucleinopathy. Specifically, our novel two-hit model combining developmental dieldrin exposure with the -synuclein (-syn) pre-formed fibril (PFF) model showed a male-specific exacerbation of PFF-induced increases in striatal dopamine (DA) turnover and motor deficits on the challenging beam 6 months post-PFF injection in male offspring developmentally exposed to dieldrin. Here, we hypothesized that alterations in DA handling contribute to the observed changes and assessed vesicular monoamine transporter 2 (VMAT2) function and DA release in this dieldrin/PFF two-hit model. Female C57BL/6 mice were exposed to 0.3 mg/kg dieldrin or vehicle every 3 days, starting at 8 weeks of age by feeding and continuing throughout breeding, gestation, and lactation. Male offspring from independent litters underwent unilateral, intrastriatal injections of -syn PFFs via stereotaxic surgery at 12 weeks of age and DA handling was assessed 4 months post-PFF injection via vesicular 3H-DA uptake assay and fast-scan cyclic voltammetry (FSCV). We observed no dieldrin-associated change in VMAT2 activity, but a dieldrin-induced increase in DA release in striatal slices in PFF-injected animals. These results suggest that developmental dieldrin exposure alters the dopaminergic response to synucleinopathy-triggered toxicity and supports our hypothesis that alterations in DA handling may underly the observed exacerbation of PFF-induced deficits in motor behavior and DA turnover. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Special Guest and lead Pro Football Focus NFL to IDP Analysis. Jon Macri (@PFF_Macri) joins John and Gary hot and heavy with defensive player free agency and the latest NFL news. It's a jammed-pack fantasy football episode on the IDPro Players Podcast. And as always, it's with nothing but the hottest latest NFL coverage. And as a bonus disclaimer, because in this particular show. There's "No Dirty O" ever mentioned!  Timeline: Jon Marci, the DEGEN! (01:30) My Fantasy League IDP Scoring Changes. (05:11) NFL Free Agency, News, and Hot Topics. (10:27) Defensive Q&A, unscripted! (31:10) ===================================================== SGPN Merch Store - https://sg.pn/store Download The Free SGPN App - https://sgpn.app Check out SGPN.TV Support us by supporting our partners WynnBET - Bet $100 and get a $100 FREE bet! - http://sg.pn/WynnBET ShadyRays.com code SGPN - 50% OFF 2+ pairs of polarized sunglasses SwordVitality.com code SGPN - Increase blood flow + stamina Tawkify.com/SGPN - 20% off when you become a client Underdog Fantasy code SGPN - 100% Deposit Match up to $100 - https://sg.pn/underdog Read & Discuss - Join the conversation Website - https://www.sportsgamblingpodcast.com Discord - https://sg.pn/discord  Reddit - https://sg.pn/reddit ===================================================== Learn more about your ad choices. Visit podcastchoices.com/adchoices

Special Guest and lead Pro Football Focus NFL to IDP Analysis. Jon Macri (@PFF_Macri) joins John and Gary hot and heavy with defensive player free agency and the latest NFL news. It's a jammed-pack fantasy football episode on the IDPro Players Podcast. And as always, it's with nothing but the hottest latest NFL coverage. And as a bonus disclaimer, because in this particular show. There's "No Dirty O" ever mentioned!  Timeline: Jon Marci, the DEGEN! (01:30) My Fantasy League IDP Scoring Changes. (05:11) NFL Free Agency, News, and Hot Topics. (10:27) Defensive Q&A, unscripted! (31:10) ===================================================== SGPN Merch Store - https://sg.pn/store Download The Free SGPN App - https://sgpn.app Check out SGPN.TV Support us by supporting our partners WynnBET - Bet $100 and get a $100 FREE bet! - http://sg.pn/WynnBET ShadyRays.com code SGPN - 50% OFF 2+ pairs of polarized sunglasses SwordVitality.com code SGPN - Increase blood flow + stamina Tawkify.com/SGPN - 20% off when you become a client Underdog Fantasy code SGPN - 100% Deposit Match up to $100 - https://sg.pn/underdog Read & Discuss - Join the conversation Website - https://www.sportsgamblingpodcast.com Discord - https://sg.pn/discord  Reddit - https://sg.pn/reddit ===================================================== Learn more about your ad choices. Visit podcastchoices.com/adchoices

Special Guest and lead Pro Football Focus NFL to IDP Analysis. Jon Macri (@PFF_Macri) joins John and Gary hot and heavy with defensive player free agency and the latest NFL news. It's a jammed-pack fantasy football episode on the IDPro Players Podcast. And as always, it's with nothing but the hottest latest NFL coverage. And as a bonus disclaimer, because in this particular show. There's "No Dirty O" ever mentioned! Timeline:Jon Marci, the DEGEN! (01:30)My Fantasy League IDP Scoring Changes. (05:11)NFL Free Agency, News, and Hot Topics. (10:27)Defensive Q&A, unscripted! (31:10)=====================================================SGPN Merch Store - https://sg.pn/storeDownload The Free SGPN App - https://sgpn.appCheck out SGPN.TVSupport us by supporting our partnersWynnBET - Bet $100 and get a $100 FREE bet! - http://sg.pn/WynnBETShadyRays.com code SGPN - 50% OFF 2+ pairs of polarized sunglassesSwordVitality.com code SGPN - Increase blood flow + staminaTawkify.com/SGPN - 20% off when you become a clientUnderdog Fantasy code SGPN - 100% Deposit Match up to $100 - https://sg.pn/underdogRead & Discuss - Join the conversationWebsite - https://www.sportsgamblingpodcast.comDiscord - https://sg.pn/discord Reddit - https://sg.pn/reddit===================================================== Learn more about your ad choices. Visit podcastchoices.com/adchoices

Special Guest and lead Pro Football Focus NFL to IDP Analysis. Jon Macri (@PFF_Macri) joins John and Gary hot and heavy with defensive player free agency and the latest NFL news. It's a jammed-pack fantasy football episode on the IDPro Players Podcast. And as always, it's with nothing but the hottest latest NFL coverage. And as a bonus disclaimer, because in this particular show. There's "No Dirty O" ever mentioned! Timeline:Jon Marci, the DEGEN! (01:30)My Fantasy League IDP Scoring Changes. (05:11)NFL Free Agency, News, and Hot Topics. (10:27)Defensive Q&A, unscripted! (31:10)=====================================================SGPN Merch Store - https://sg.pn/storeDownload The Free SGPN App - https://sgpn.appCheck out SGPN.TVSupport us by supporting our partnersWynnBET - Bet $100 and get a $100 FREE bet! - http://sg.pn/WynnBETShadyRays.com code SGPN - 50% OFF 2+ pairs of polarized sunglassesSwordVitality.com code SGPN - Increase blood flow + staminaTawkify.com/SGPN - 20% off when you become a clientUnderdog Fantasy code SGPN - 100% Deposit Match up to $100 - https://sg.pn/underdogRead & Discuss - Join the conversationWebsite - https://www.sportsgamblingpodcast.comDiscord - https://sg.pn/discord Reddit - https://sg.pn/reddit===================================================== Learn more about your ad choices. Visit podcastchoices.com/adchoices

Special Guest and lead Pro Football Focus NFL to IDP Analysis. Jon Macri (@PFF_Macri) joins John and Gary hot and heavy with defensive player free agency and the latest NFL news. It's a jammed-pack fantasy football episode on the IDPro Players Podcast. And as always, it's with nothing but the hottest latest NFL coverage. And as a bonus disclaimer, because in this particular show. There's "No Dirty O" ever mentioned!  Timeline: Jon Marci, the DEGEN! (01:30) My Fantasy League IDP Scoring Changes. (05:11) NFL Free Agency, News, and Hot Topics. (10:27) Defensive Q&A, unscripted! (31:10) ===================================================== SGPN Merch Store - https://sg.pn/store Download The Free SGPN App - https://sgpn.app Check out SGPN.TV Support us by supporting our partners WynnBET - Bet $100 and get a $100 FREE bet! - http://sg.pn/WynnBET ShadyRays.com code SGPN - 50% OFF 2+ pairs of polarized sunglasses SwordVitality.com code SGPN - Increase blood flow + stamina Tawkify.com/SGPN - 20% off when you become a client Underdog Fantasy code SGPN - 100% Deposit Match up to $100 - https://sg.pn/underdog Read & Discuss - Join the conversation Website - https://www.sportsgamblingpodcast.com Discord - https://sg.pn/discord  Reddit - https://sg.pn/reddit ===================================================== Learn more about your ad choices. Visit podcastchoices.com/adchoices

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.01.28.526024v1?rss=1 Authors: Feller, B., Fallon, A., Luo, W., Nguyen, P. T., Shlaifer, I., Lee, A. K., Karkout, S., Bourgault, S., Durcan, T. M., Takahashi, H. Abstract: Synucleinopathies form a group of neurodegenerative diseases defined by misfolding and aggregation of alpha-synuclein (-syn). Abnormal accumulation and spreading of -syn aggregates lead to synapse dysfunction and neuronal cell death. Yet, little is known about synaptic mechanisms underlying -syn pathology. Here we identified {beta}-isoforms of neurexins ({beta}-NRXs) as presynaptic organizing proteins that interact with -syn preformed fibrils (-syn PFFs), toxic -syn aggregates, but not -syn monomers. Our cell surface protein binding assays and surface plasmon resonance assays reveal that -syn PFFs bind directly to {beta}-NRX through their N-terminal histidine-rich domain (HRD) at nanomolar range (Kd: ~500 nM monomer equivalent). Furthermore, our artificial synapse formation assays show that -syn PFFs diminish excitatory and inhibitory presynaptic organization induced by a specific isoform of neuroligin 1 that binds only {beta}-NRXs, but not -isoforms of neurexins. Thus, our data suggest that -syn PFFs interact with {beta}-NRXs to inhibit {beta}-NRX-mediated presynaptic organization, providing novel molecular insight into how -syn PFFs induce synaptic pathology in synucleinopathies such as Parkinson's disease and dementia with Lewy bodies. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

The boys are joined by Steve Manella from Pro Football Focus to discuss Sam Howell getting his first start vs Dallas, expectations for Howell, and score predictions. Them they wrap up the episode answering fan questions!Support the show

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.09.23.508066v1?rss=1 Authors: Konovalova, J., Er, S., Barut, J., Rafa-Zablocka, K., Luk, K., Figiel, M., Airavaara, M., Domanskyi, A., Chmielarz, P. Abstract: Motor symptoms of Parkinson's disease (PD) are caused by the loss of dopamine neurons in the substantia nigra pars compacta. Current PD therapies offer only symptomatic relief, and the research on novel ways to stop or slow down the degeneration of dopamine neurons in PD attracts considerable efforts. A characteristic feature of PD is the abnormal accumulation and spread of misfolded -synuclein (-syn) protein leading to the formation of Lewy neurites and bodies in different neuronal populations, including dopamine neurons. The process of Lewy body formation compromises neuronal functions and contributes to the progression of the disease and neurodegeneration in PD patients. Treatments preventing -syn misfolding, aggregation and/or spread may therefore provide much-needed disease-modifying therapies for PD. We and others have demonstrated that -syn aggregation and Lewy body formation can be modelled in primary neuronal cultures treated with -syn pre-formed fibrils (PFFs). Using this approach, we have identified several factors preventing the accumulation of phosphorylated -syn in dopamine neurons in vitro and in vivo. In particular, we and others have demonstrated a prominent role of PKB/AKT pathway activation in promoting the survival of dopamine neurons. Here, we utilize lentiviral vectors (LVs) to express constitutively active myristoylated serine-threonine protein kinase AKT1 (mAKT1) in primary dopamine neurons. We show that lentivirally-delivered mAKT1 promoted survival of dopamine neurons after thapsigargin-induced endoplasmic reticulum (ER) stress and prevented fibril-induced accumulation of phosphorylated -syn. Furthermore, using pharmacological tools, we demonstrate that this activity of mAKT1 is dependent on the functional Cathepsins B and D. These proof-of-principle results demonstrate the critical importance of lysosomal enzymes for processing misfolded -syn and establish a basis for the use of LVs to develop neuroprotective gene therapy strategies for dopamine neurons in PD. Copy rights belong to original authors. Visit the link for more info Podcast created by PaperPlayer

More on the top NFL stories going into this season and PFFs top 50 list Guest: Bucky Brooks See omnystudio.com/listener for privacy information.

PFF put out their Combined Dynasty Rankings a few weeks back and boy oh boy, were they a sight to behold! Jordan and Baumer have a big brain talk about the actionability of this exercise before looking into the IDP rankings themselves. Buckle up! Underdog $100 Deposit BONUS⬇️⬇️ http://bit.ly/3uBQuW2 Patreon: https://bit.ly/idparmy THE ULTIMATE IDP INDEX: https://bit.ly/idparmy Fantasy Football Rankings: https://bit.ly/2Wb7CGy $100 Deposit Match BONUS for MONKEY KNIFE FIGHT!!!! https://bit.ly/3wOqSHb Apple Podcast: https://apple.co/2XNDz66 Spotify: https://spoti.fi/33HovKV How To Draft IDPs Like A Pro: https://bit.ly/3ifsFjZ Follow The IDP Army - http://www.idparmy.com Follow Offensive Points - http://www.twitter.com/OffensivePoints ---- Patreon: https://bit.ly/idparmy Twitter: http://www.twitter.com/theidparmy Jordan: http://www.twitter.com/50shadesofdrunk Billy: http://www.twitter.com/hombrevender Joe: http://www.twitter.com/Opeconomist Josh: http://www.twitter.com/joshallSTL

What is up everyone, we are hoping that you are having a fine week so far and that our little how here only makes it better. This week we got some fun ones, Kat takes us through the history of Fort Sumpter and it significance to the American Civil War. Kaleigh then closes us out with the story of the defibitely just friends and two of the most iconic pirates of all time, Anne Bonny and Mary Read. Let's chat!Twitter; @TINAHLpodcastEmail: thisisnotahistorylecture@gmail.comRemember to rate us wherever you can!

Pro Football Focus released their top 100 players from the 2021 NFL season. Where did some of your favorite Cowboys land?

We break down some of what we saw on film with the Chargers and PFFs grades to preview the week 5 opponents. Then we make our picks for the week's NFL action. --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app

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The best Ole Miss show on the internet. Streaming every weekday at 11 ET/10 CT. Steve talks about the coming Game 7 and the need for the team to be Loose and Confident today. It is time we performed to the level offensively our ranking says we are. LFG...Also we look at PFFs rankings of top 3 college football coaches...I have notes, Will always tell it like it is! Facebook: Positively Ole Miss Twitter: @TheStevenWillis @TheRebelWalk YouTube: Positively Ole Miss Twitch: positivelyolemiss

The Florida Gators should be a top 5 team in college football. Brandon Olsen revisits the conversation from yesterday's episode about PFFs rankings.Should Florida be a top 5 team?How far can Florida Gators baseball go?How good is this Florida Gators softball team?Support Us By Supporting Our Sponsors!Built BarBuilt Bar is a protein bar that tastes like a candy bar. Go to builtbar.com and use promo code “LOCKED15,” and you'll get 15% off your next order.BetOnline AGThere is only 1 place that has you covered and 1 place we trust. Betonline.ag! Sign up today for a free account at betonline.ag and use that promocode: LOCKEDON for your 50% welcome bonus.Rock AutoAmazing selection. Reliably low prices. All the parts your car will ever need. Visit RockAuto.com and tell them Locked On sent you.Lucy.coGo to LUCY.CO and use Promo Code LOCKEDONCOLLEGE to get 20% off all products on your first order, including gum or lozenges! Learn more about your ad choices. Visit podcastchoices.com/adchoices

The Florida Gators should be a top 5 team in college football. Brandon Olsen revisits the conversation from yesterday's episode about PFFs rankings. Should Florida be a top 5 team? How far can Florida Gators baseball go? How good is this Florida Gators softball team? Support Us By Supporting Our Sponsors! Built Bar Built Bar is a protein bar that tastes like a candy bar. Go to builtbar.com and use promo code “LOCKED15,” and you’ll get 15% off your next order. BetOnline AG There is only 1 place that has you covered and 1 place we trust. Betonline.ag! Sign up today for a free account at betonline.ag and use that promocode: LOCKEDON for your 50% welcome bonus. Rock Auto Amazing selection. Reliably low prices. All the parts your car will ever need. Visit RockAuto.com and tell them Locked On sent you. Lucy.co Go to LUCY.CO and use Promo Code LOCKEDONCOLLEGE to get 20% off all products on your first order, including gum or lozenges! Learn more about your ad choices. Visit podcastchoices.com/adchoices

On this episode we break down the current 2021 Panthers roster, discuss whether each position group has been upgraded or downgraded, and tell you what positions still need to be addressed. We also pay off a bet and marvel at PFFs stupidity. --- Support this podcast: https://anchor.fm/meowmixpodcast/support

Sejam bem-vindos ao milésimo ducentésimo décimo quarto Spin de Notícias, o seu giro diário de informações científicas... em escala sub-atômica. E nesse Spin de Notícias falaremos sobre...  1 ano de Pandemia no Brasil! O que é um respirador PFF2? Quais outras classes de respiradores? Qual é a diferença entre uma PFF e uma N95? Como funciona um respirador N95? Eles podem ser reutilizados? Devemos usar PFFs ou máscaras caseiras de pano?

Sejam bem-vindos ao milésimo ducentésimo décimo quarto Spin de Notícias, o seu giro diário de informações científicas... em escala sub-atômica. E nesse Spin de Notícias falaremos sobre...  1 ano de Pandemia no Brasil! O que é um respirador PFF2? Quais outras classes de respiradores? Qual é a diferença entre uma PFF e uma N95? Como funciona um respirador N95? Eles podem ser reutilizados? Devemos usar PFFs ou máscaras caseiras de pano?

Austin Gayle, of Pro Football Focus, joins the show. Austin joins Bill to talk about what he saw from the NFL championship weekend. Austin and Bill talk Superbowl match up as well as some of the highest rated players who will be taking part in the Superbowl.

Jaz and Edd are joined by Pro Football Focus analyst Austin Gayle. They discuss the quarter back class for the 2021 draft, whether the jets should consider Justin Fields or Zach Wilson at 2 overall as well as Austins take on the dolphins situation picking at 3. Additionally, Austin explains why Patrick Queen has graded so poorly this season as well as giving us some takes for the upcoming playoffs.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.11.17.387175v1?rss=1 Authors: Chou, T.-W., Chang, N. P., Krishnagiri, M., Patel, A. P., Atkins, C., Daniels, B. P. Abstract: Parkinson's disease (PD) is a neurodegenerative disorder characterized by death of midbrain dopamine neurons. The pathogenesis of PD is poorly understood, though misfolded and/or aggregated forms of the protein -synuclein have been implicated in several neurodegenerative disease processes, including neuroinflammation and astrocyte activation. Astrocytes in the midbrain play complex roles during PD, initiating both harmful and protective processes that vary over the course of disease. However, despite their significant regulatory roles during neurodegeneration, the cellular and molecular mechanisms that promote pathogenic astrocyte activity remain mysterious. Here, we show that -synuclein preformed fibrils (PFFs) induce pathogenic activation of human midbrain astrocytes, marked by inflammatory transcriptional responses, downregulation of phagocytic function, and conferral of neurotoxic activity. These effects required the necroptotic kinases RIPK1 and RIPK3, but were independent of MLKL and necroptosis. Instead, both transcriptional and functional markers of astrocyte activation occurred via RIPK-dependent activation of NF-{kappa}B signaling. Our study identifies a previously unknown function for -synuclein in promoting neurotoxic astrocyte activation, as well as new cell death-independent roles for RIP kinase signaling in the regulation of glial cell biology and neuroinflammation. Together, these findings highlight previously unappreciated molecular mechanisms of pathologic astrocyte activation and neuronal cell death with implications for Parkinsonian neurodegeneration. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.11.17.387415v1?rss=1 Authors: Underwood, R., Gannon, M., Pathak, A., Kapa, N., Chandra, S., Klop, A., Yacoubian, T. A. Abstract: Alpha-synuclein (syn) is the key component of proteinaceous aggregates termed Lewy Bodies (LBs) that pathologically define a group of disorders known as synucleinopathies, including Parkinsons Disease (PD) and Dementia with Lewy Bodies (DLB). Syn is hypothesized to misfold and spread throughout the brain in a prion-like fashion. Transmission of syn necessitates the release of misfolded syn from one cell and the uptake of that syn by another, in which it can template the misfolding of endogenous syn upon cell internalization. 14-3-3 proteins are a family of highly expressed brain proteins that are neuroprotective in multiple PD models. We have previously shown that 14-3-3{theta} acts as a chaperone to reduce syn aggregation, cell-to-cell transmission, and neurotoxicity in the in vitro pre-formed fibril (PFF) model. In this study, we expanded our studies to test the impact of 14-3-3s on syn toxicity in the in vivo syn PFF model. We used both transgenic expression models and adenovirus associated virus (AAV)-mediated expression to examine whether 14-3-3 manipulation impacts behavioral deficits, syn aggregation, and neuronal loss in the PFF model. 14-3-3{theta} transgene overexpression in cortical and amygdala regions rescued social dominance deficits induced by PFFs at 6 months post injection, whereas 14-3-3 inhibition by transgene expression of the competitive 14-3-3 peptide inhibitor difopein in the cortex and amygdala accelerated social dominance deficits. The behavioral rescue by 14-3-3{theta} overexpression was associated with delayed syn aggregation induced by PFFs in these brain regions. Conversely, 14-3-3 inhibition by difopein in the cortex and amygdala accelerated syn aggregation and cortical pyramidal neuron loss induced by PFFs. 14-3-3{theta} overexpression by AAV in the substantia nigra (SN) also delayed syn aggregation in the SN and partially rescued PFF-induced dopaminergic cell loss in the SN. 14-3-3 inhibition in the SN accelerated nigral syn aggregation and increased PFF-induced dopaminergic cell loss. These data indicate a neuroprotective role for 14-3-3{theta} against syn toxicity in vivo. Copy rights belong to original authors. Visit the link for more info

In this episode, I talk to Krista and Sandrine, two college professors who are PFFs (professional friends forever). These lovely ladies will have you laughing out loud as they share their stories of partnership and collaboration on special projects and professional development  “adventures” together. They support, encourage and help each

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.10.21.349191v1?rss=1 Authors: Boutros, S. J., Raber, J., Unni, V. K. Abstract: Alpha-synuclein () is a small protein involved in neurodegenerative diseases known as synucleinopathies. The phosphorylated form (psyn) is the primary component of protein aggregates known as Lewy bodies (LBs), which are the hallmark of diseases such as Parkinsons disease (PD) and Dementia with Lewy bodies (DLB). Synucleinopathies might spread in a prion-like fashion, leading to a progressive emergence of symptoms over time. syn pre-formed fibrils (PFFs) induce LB-like pathology in wild-type (WT) mice, but there are remaining questions about the progressive spreading of pathology and the cognitive and behavioral effects. Here, we induced LB-like pathology in the bilateral motor cortex of WT mice and assessed behavioral and cognitive performance. As there are no long-term effective treatments for synucleinopathies, and no therapies slow or reduce the spreading of LBs, we also assessed the effects of a mouse syn-targeted antisense oligonucleotides (ASOs) on pathology and behavioral and cognitive performance starting 5 weeks after ASO treatment. At 3 months post-PFF injection (mpi), mice injected with PFFs showed cognitive impairments and mild motor impairments. At 6 mpi, PFF-injected mice showed further cognitive and motor impairments that were partially ameliorated by the ASO. ASO treatment also reduced LB-like pathology, and pathology was significantly correlated with cognitive measures. However, the particular mouse ASO used in these assays was also associated with some possible off-target effects, defined as effects not involving lowering of syn, such as a decline in body weight. These results add to what is known about the progressive nature of the PFF model of synucleinopathies. These data also support the therapeutic potential of ASOs to improve Lewy pathology and associated behavioral and cognitive phenotypes. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.10.12.335885v1?rss=1 Authors: Jarvela, T. S., Chaplot, K., Lindberg, I. Abstract: Alpha-synuclein pre-formed fibrils (PFFs) represent a promising model system for the study of cellular processes underlying cell-to- cell transmission of -synuclein proteopathic aggregates. However, the ability to differentiate the fate of internalized PFFs from those which remain in the extracellular environment remains limited due to the propensity for PFFs to adhere to the cell surface. Removal of PFFs requires repeated washing or specific quenching of extracellular fluorescent PFF signals. In this paper we present a new method for analyzing the fate of internalized -synuclein. We inserted a tobacco etch virus (TEV) protease cleavage site between -synuclein and green fluorescent protein. As the TEV protease is highly specific, non-toxic, and active under physiological conditions, we are able to use protection from TEV cleavage to distinguish internalized PFFs from those which remain attached to the cell surface. Using this experimental paradigm, downstream intracellular events can be analyzed via live or fixed cell microscopy as well as by Western blotting. We suggest that this method will be useful for understanding the fate of PFFs after endocytosis under various experimental manipulations. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.09.28.314526v1?rss=1 Authors: Blumenstock, S., Sun, F., Marinkovic, P., Sgobio, C., Liebscher, S., Herms, J. Abstract: Alpha-synucleinopathies are characterized by self-aggregation of the protein alpha-synuclein (a-syn), causing alterations on the molecular and cellular level. To unravel the impact of trans-neuronal spreading and templated misfolding of a-syn on the microcircuitry of remotely connected brain areas, we investigated cortical neuron function in awake mice 9 months after a single intrastriatal injection of a-syn preformed fibrils (PFFs), using in vivo two-photon calcium imaging. We found altered function of layer 2/3 cortical neurons in somatosensory cortex (S1) of PFF-inoculated mice, as witnessed by an enhanced response to whisking and increased synchrony, accompanied by a decrease in baseline Ca2+ levels. Stereological analyses revealed a reduction in GAD67-positive inhibitory cells in S1 in PFF-injected brains. These findings point to an impaired excitation/inhibition balance as an important pathomechanism in alpha-synucleinopathies and demonstrate a clear association between the spread of toxic proteins and the initiation of altered neuronal function in remotely connected areas. Copy rights belong to original authors. Visit the link for more info

Thomas Booker, a Stanford DE, who won the Jimmy Rodgers Jr. Lineman Award, got a All Pac 12 honorable mention, and was ranked 7th in PFFs top 10 defensive players for the 2021 NFL Draft joins today’s pod to talk about football and proving ESPN wrong. --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app --- Send in a voice message: https://anchor.fm/nfldaily/message

Jacob and Usayd are back as they discuss 49ers who made PFFs top 100 list, talk about positional needs, and more!

The U.S. Consulate in Auckland sponsored two U.S.designers to attend the Pacific Fusion Fashion Show (PFFS) - Ari South from Hawaii, and Afa Ah Loo from Utah – you may have seen them on America's reality show Bravo's Project Runway. While in New Zealand the Pacific Fusion Fashion U.S. designers took time to work with other local & international designers at a 2 day workshop supported by the Ministry of Business, Innovation and Employment. Ari South and Afa Ah Loo spoke to the other 11 designers to share their expertise on the business side of the fashion industry! The 2019 Pacific Fusion Fashion Show was incredible!! We were treated to the VIP experience, including a backstage tour to meet all the models and designers. Check out these quick snaps from the night (and full album links below). A massive shout out to our good friend and Pacific Women Leader Nora Swann plus a special mention to our sponsored designers Afa Ah Loo and Ari South!! While at PFFS, Jethro from the U.S. Embassy caught up with Ari South... More photos on FlickR (Afa album) (Ari album) (PFFS album) Transcript.

The U.S. Consulate in Auckland sponsored two U.S.designers to attend the Pacific Fusion Fashion Show (PFFS) - Ari South from Hawaii, and Afa Ah Loo from Utah – you may have seen them on America's reality show Bravo's Project Runway. While in New Zealand the Pacific Fusion Fashion U.S. designers took time to work with other local & international designers at a 2 day workshop supported by the Ministry of Business, Innovation and Employment. Ari South and Afa Ah Loo spoke to the other 11 designers to share their expertise on the business side of the fashion industry! The 2019 Pacific Fusion Fashion Show was incredible!! We were treated to the VIP experience, including a backstage tour to meet all the models and designers. Check out these quick snaps from the night (and full album links below). A massive shout out to our good friend and Pacific Women Leader Nora Swann plus a special mention to our sponsored designers Afa Ah Loo and Ari South!! While at PFFS, Jethro from the U.S. Embassy caught up with Afa Ah Loo... More photos on FlickR (Afa album) (Ari album) (PFFS album) Transcript.

Mike can’t believe two things: The first - how is it that Odell Beckham Jr. can feel “disrespected” after being trade? The second - how is Roger Goodell so bad a disciplining players? On this episode of The GM Shuffle, Mike and Adnan are in disbelief at the commissioners inaction towards the Tyreek Hill allegations. Mike and Adnan also look at the PFFs top 10 QBs going into the 2019 season, the “Detroit Patriots” moniker, and they discuss the best offensive head coaches in the NFL. Learn more about your ad choices. Visit megaphone.fm/adchoices

Hey Medicare Nation! www.TheMedicareNation.com On the Last episode.....I spoke to you about Medicare Supplement Plan "F" and High Deductible Plan F. Today....I'm going to talk about Medicare Supplement Plan "G" and Plan "N" Plan "G" allows you to "purchase" an insurance policy, where you pay a monthly premium to the carrier...... in return...... Medicare Supplement Plan G, will pay ALL your Medically necessary out-of-pocket deductibles, co-insurance and co-pays...... EXCEPT for ..... The Annual Part B Deductible. YOU will be responsible for the Annual Part B deductible each year. Currently.... in 2019, the Annual Part B Deductible is $185.00. So..... when you seek medical care in the beginning of the year.... you will pay out-of-pocket until you hit the $185.00 Part B Deductible. After you pay the $185.00 Part B Deductible....you will NOT be responsible for ANY other deductibles, co-pays or co-insurance under Medicare Supplement Plan G, that are medically necessary under Medicare. Plan "N" allows you to "purchase" an insurance policy, where you pay a monthly premium to the carrier...... in return...... Medicare Supplement Plan N, will pay ALL your Medically necessary out-of-pocket deductibles, co-insurance and co-pays...... EXCEPT for ..... 1. The Annual Part B Deductible ($185.00 in 2019) 2. A co-pay of up to $20.00 for each doctor visit. 3. A co-pay of $50.00 if you go to the Emergency Room and you are "Discharged" from the Emergency Room. If you are "admitted" to the hospital from the ER... you will NOT incur a $50.00 co-pay. If you have paid all of your Part B Deductible, you will have NO other out-of-pocket costs while you are an inpatient in the hospital. 4. If you seek treatment, testing or diagnostic testing from a physician or facility that does NOT accept Medicare, you WILL be responsible for 100% of the cost of that service. The provider or facility can legally charge you 15% above and beyond the Medicare Allowable charge. It is vital that you always ask prior to receiving care, a test or doctor visit....if the physician or facility "accepts Medicare."  If they do.....your charges are outlined above. If they do not accept Medicare..... you may be responsible for ALL of the charges, up to 15% of the Medicare Allowable charge. ASK BEFORE YOU SEE A DR or RECEIVE TREATMENT! Prices for Medicare Supplements VARY by zipcode! Get quotes from MANY different insurance carriers prior to enrolling in a plan. You could save hundreds....sometimes over a thousand dollars a year! HAVE a Question for ME? Send it to me at  Support@TheMedicareNation.com I will answer ALL emails I receive.... personally! If the answer to your question will take me more than 1 paragraph to answer... or .... it is necessary to do some research for you in order to answer the question.... I will respond and advise you to hire me as your consultant. Many of your questions may be answered on the official Medicare website - www.Medicare.gov Always do YOUR Due Dilligence before you enroll in a Medicare Plan! Consider leaving a review & rating on the Medicare Nation Podcast page in iTunes.  http://nation.reviews/medicare8   Thanks for listening to Medicare Nation! Show your Parents how to "Subscribe" to Medicare Nation. With over 100 episodes... most of their questions will be answered by listening to my episodes. This way... your parents are NOT bothering YOU for information about Medicare! Enjoy time for yourself and your family! Teach people how to "subscribe" to Medicare Nation! YOU will be responsible for the Annual Part B deductible each year.

Background: Somatic cell nuclear transfer (SCNT) is currently the most efficient and precise method to generate genetically tailored pig models for biomedical research. However, the efficiency of this approach is crucially dependent on the source of nuclear donor cells. In this study, we evaluate the potential of primary porcine kidney cells (PKCs) as cell source for SCNT, including their proliferation capacity, transfection efficiency, and capacity to support full term development of SCNT embryos after additive gene transfer or homologous recombination. Results: PKCs could be maintained in culture with stable karyotype for up to 71 passages, whereas porcine fetal fibroblasts (PFFs) and porcine ear fibroblasts (PEFs) could be hardly passaged more than 20 times. Compared with PFFs and PEFs, PKCs exhibited a higher proliferation rate and resulted in a 2-fold higher blastocyst rate after SCNT and in vitro cultivation. Among the four transfection methods tested with a GFP expression plasmid, best results were obtained with the Nucleofector (TM) technology, resulting in transfection efficiencies of 70% to 89% with high fluorescence intensity, low cytotoxicity, good cell proliferation, and almost no morphological signs of cell stress. Usage of genetically modified PKCs in SCNT resulted in approximately 150 piglets carrying at least one of 18 different transgenes. Several of those pigs originated from PKCs that underwent homologous recombination and antibiotic selection before SCNT. Conclusion: The high proliferation capacity of PKCs facilitates the introduction of precise and complex genetic modifications in vitro. PKCs are thus a valuable cell source for the generation of porcine biomedical models by SCNT.