Everyday Wellness

Today, I had the honor of connecting with Ashley Koff. She is a leading voice in personalized nutrition and the founder of the Better Nutrition Program. With over 25 years of experience and the groundbreaking GLP-1 Optimization System to her name, she's helped redefine how we approach sustainable weight health. In our conversation, we dive into how her book reframes the concept of healthy weight. We explore integrative perspectives on digestive health and GLP-1s, why many women blame themselves when they struggle to lose weight, and how Ashley's framework helps them remove that self-blame. We also discuss issues surrounding info-besity and the “less is more” approach, natural ways to support appetite regulation and satiety signaling, key areas of digestive health, and the importance of detoxification. Ashley also shares the red flags she sees in women who are undernourishing themselves or over-fasting, things to consider when you want to stop taking GLP-1s, and her opinions on new drug therapies. Join us for today's thought-provoking and insightful conversation around metabolic health and weight-loss resistance for women in middle age, perimenopause, and menopause. IN THIS EPISODE, YOU WILL LEARN: The interconnection that exists between digestion, hormones, and metabolic signaling How the hormonal fluctuation that occurs in perimenopause disrupts women's digestion What drives satiety?  How GLP-1 medications simply amplify, extend, or mimic an existing communication loop within the body rather than creating new pathways Why do women blame themselves when they cannot lose weight? How info-besity blocks the body from doing what it is naturally designed to do  Why detoxification is essential for supporting natural digestive and metabolic processes The red flags that indicate undernourishment or over-fasting in women What you need to think about before stopping GLP-1s Bio: Ashley Koff, RD, is the USA Today bestselling author of⁠ Your Best Shot⁠ (HarperOne) and founder of⁠ The Better Nutrition Program⁠ (BNP). An acclaimed weight-health expert and practitioner for more than 25 years, Koff is leading a transformative movement in personalized nutrition, turning “better, not perfect” choices into practical, sustainable strategies that deliver real outcomes. Your Best Shot introduces weight-health hormones (GLP-1, GIP, CCK, PYY) as the regulators of weight health, offering the first-ever assessment of their function and a personalized optimization system—shot or not. A trusted expert featured across major media and a sought-after educator for health professionals, Ashley has been recognized as one of CNN's Top 100 Health Makers and featured in InStyle as “Hollywood's Leading Dietitian.” Connect with Cynthia Thurlow   Follow on ⁠X⁠, ⁠Instagram⁠ & ⁠LinkedIn⁠ Check out Cynthia's ⁠website⁠ Submit your questions to ⁠support@cynthiathurlow.com⁠ Join other like-minded women in a supportive, nurturing community:⁠ The Midlife Pause/Cynthia Thurlow⁠  Cynthia's⁠ Menopause Gut Book⁠ is on presale now! Cynthia's⁠ Intermittent Fasting Transformation⁠ Book ⁠The Midlife Pause Supplement Line⁠ Connect with Ashley Koff ⁠The Better Nutrition Program⁠  On ⁠Instagram⁠ and⁠ Substack⁠ On other social media: @Ashley Koff

Today, I am honored to connect with a friend and fellow nurse practitioner, Marcelle Pick! Marcelle is passionate about transforming how women experience healthcare through an integrative approach. She has successfully treated thousands of women through her unique approach to wellness. Marcelle is currently a faculty member of The Institute of Functional Medicine and has served as a Medical Advisor to Healthy Living Magazine. She has written countless articles and multiple books, including Is It Me or My Hormones? I always think of Marcelle as a pioneer in the women's health/nurse practitioner space. In this episode, we dive into her background and the impact of the Women's Health Initiative. We discuss the limitations of the traditional allopathic model regarding hormones, common misconceptions about adrenal health, perimenopause, and menopause, adverse childhood events and adrenal health, how lifestyle affects our sex hormones, fibroids, endometriosis, PMS, PMDD, and contraception for perimenopause. We speak about endocrine disruptors, mold, and micro toxins. We also get into ways to think about hormone replacement therapy and ways to address intimacy and low libido. I love connecting with other nurses and nurse practitioners! I hope you will love today's conversation with Marcelle as much as I did! IN THIS EPISODE YOU WILL LEARN: Marcelle was part of the first all-women practice in the country. How the Women's Health Initiative has impacted health care for women. The limitations of the traditional allopathic model are particularly in terms of perimenopause, menopause, and hormones. The less-common labs Marcelle likes to look at for her patients Marcelle shares her approach to unraveling the symptoms of perimenopause. Some unique ways in which Marcelle deals with problems like fibroids and endometriosis. How childhood trauma could lead to adrenal and autoimmune issues, weight-loss resistance, and various other health problems. Many of the things Marcelle recommended for treating PMS and PMDD back in the day (1985) have now become the standard of care. Contraceptive options for women in perimenopause. The impact of stress on adrenal function during perimenopause and menopause. Marcelle dives into liver health and detoxification, chemicals and other factors that could impact our health, and changes we can make to avoid problems and feel better. What Marcelle does to help women with low libido. Connect with Cynthia Thurlow Follow on X, Instagram & LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community (The Midlife Pause/Cynthia Thurlow)  Cynthia's Menopause Gut Book is on presale now! Cynthia's Intermittent Fasting Transformation Book The Midlife Pause supplement line Connect with Marcelle Pick On her ⁠website⁠    ⁠Facebook ⁠Instagram⁠ All of Marcelle's books are available on ⁠Amazon

I am delighted to reconnect with Dr. Jason Fung today. He is a trained nephrologist and world-leading expert on intermittent fasting and metabolic health. He has authored multiple books, including the New York Times best-seller, The Obesity Code, The Diabetes Code, and, more recently, The Hunger Code.   In our conversation today, we unpack the obsessive focus on the calories-in, calories-out model, which is neither practical nor effective. We explore the root causes behind the narrow-minded thinking that calories alone drive obesity, differences between types of hunger and conditioned responses, how hormones affect other hormones, and lessons about GLP-1s. We examine the critical importance of fiber and protein, and offer clarity around carbohydrates. We also cover the impact of meal timing, sleep, and circadian biology, the fat thermostat and sympathetic tone, nutrition, stress, and mindful eating, and dive into the issue of ultra-processed foods. Join us for an insightful conversation that challenges conventional wisdom and offers a nuanced and sustainable approach to understanding hunger, metabolism, and long-term health. IN THIS EPISODE, YOU WILL LEARN: “Calories in, calories out” framework is technically correct, but practically useless How the homeostatic, hedonic, and conditioned hunger types differ Dr. Fung shares his take on GLP-1 medications How fiber stimulates natural GLP-1 production Processed and natural carbohydrates produce vastly different glucose and insulin responses. Avoid eating late-night meals! Complex relationship between hunger, hormonal regulation, and sleep quality Hormones that drive body fat regulation  How bitter foods suppress appetite and enhance satiety Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow  Cynthia's Menopause Gut Book is on presale now! Cynthia's Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Connect with Dr. Jason Fung On his website Instagram and YouTube Dr. Fung's latest book, The Hunger Code, will come out in March. Pre-order on Amazon!

Most of the questions I've been asked lately have been about my current hormone replacement regimen. So I have dedicated this episode to unpacking what I use transdermally, orally, and topically for hormone replacement therapy. As you might expect, my approach includes the basics, along with a few additional strategies. I also share a topical option for facial skin that Dr. Felice Gersh recently recommended. Stay tuned to find out what I do for hormone replacement therapy. IN THIS EPISODE, YOU WILL LEARN: What you need to optimize first, before even considering adding any additional items Why I might need to increase the dosage of my Dotti transdermal estrogen patch Why I consider estradiol the most potent estrogen our bodies make before menopause Factors that influenced my decision to prioritize estradiol therapy The role of testosterone, beyond libido Why I use progesterone The value of intra-vaginal products Why I use a compounded intra-vaginal product  What copper peptides, estriol, DMAE, and hyaluronic acid may do for aging skin Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow  Cynthia's Menopause Gut Book is on presale now! Cynthia's Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Research Links Efficacy of Transdermal Estradiol and Micronized Progesterone in the Prevention of Depressive Symptoms in the Menopause Transition: A Randomized Clinical Trial Hormone Replacement Therapy Effects of Ultra–Low-Dose Transdermal Estradiol on Cognition and Health-Related Quality of Life   Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data Treatment of skin aging with topical estrogens SCF-induced airway hyperreactivity is dependent on leukotriene production The role of dimethylaminoethanol in cosmetic dermatology The Missing lnc(RNA) between the pancreatic β-cell and diabetes

Today, I am thrilled to connect with Dr. Sonya Jensen, a naturopathic physician on a mission to transform how women understand themselves and their bodies. She believes women are central to their families and communities, and by supporting women, we create a ripple effect that supports the whole. In our conversation, we explore the sense of selfishness many women feel when advocating for their needs, and why choosing ourselves, especially in midlife, is essential. We discuss science-versus-soul transformations, gestational silence and trauma, and the physiological effects shaping this generation and those to come. We also unpack how stress impacts the immune system and autoimmunity, why stress reduction techniques are the key to vagus nerve activation, the link between mental health and hormones, womb-wisdom and generational influences, how grief and sadness can influence us profoundly, and the value of trusting our intuition and embracing the gifts of aging. I know you will enjoy this discussion with Sonya Jensen. She shares a gentle, loving, and kind message for women- one that is well worth reflecting upon. Be sure to keep an eye out for her upcoming book, Heal Your Hormones, Reclaim Yourself, scheduled for release in early 2026, where she connects hormonal chaos, emotional overload, and relationship pain through her integrative method. After the recording, Dr. Jensen noted a clarification: there were 50 famines in total during British rule in India, not 50 famines in a single year. IN THIS EPISODE, YOU WILL LEARN: How awareness practices can help you become more physically regulated when things feel overwhelming Why friable emotions are not due to personal failure or a faulty mindset How to reconnect with your body The benefit of body-based practices for supporting nervous system regulation    What is womb wisdom? How womb wisdom influences the way we show up in the world Some of the biggest obstacles to women's healing Why so many women struggle to trust themselves Why loneliness can surface as women age, and ways to counter it   Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow  Cynthia's Menopause Gut Book is on presale now! Cynthia's Intermittent Fasting Transformation Book The Midlife Pause supplement line Connect with Dr. Sonya Jensen On her book website: Heal Your Hormones, Reclaim Yourself Instagram

Today, I have the honor of connecting with Dave Watumull, the Co-founder and CEO of AX3 Life, a consumer health company dedicated to astraxanthin products, education, and community. Dave is on a mission to introduce the world to astaxanthin. Astaxanthin is a marine-derived super-nutrient that supports whole-body health and longevity, a pursuit that has inspired Dave for over 25 years of research, development, and commercialization. In our discussion, Dave explains what astraxanthin is, its functions, and its key properties. We explore specific studies where astraxanthin has been particularly beneficial for lipids, particularly oxidized LDL. We discuss the impact of nutrition and examine the results of astraxanthin research on sarcopenia, cognition, and joints, liver, skin, and eye health. We also cover the dose-dependent effects of astraxanthin, and Dave answers a series of rapid-fire questions. Astaxanthin is truly a supplement worth considering. I'll be taking it to see if it helps reduce my Lp(a). My husband and one of my children also have high Lp(a), so we will all try it as a family experiment, and I will share the results. IN THIS EPISODE, YOU WILL LEARN: Astaxanthin's origins and mechanisms The ideal dosing range for starting astaxanthin, and how the benefits appear even at lower doses What a dose-dependent effect actually means The importance of fundamentals like consistent sleep, a balanced, nutrient-dense diet, and daily physical activity How astaxanthin forms a protective antioxidant network The value of astaxanthin for supporting brain and ocular health How astaxanthin reduces inflammation without suppressing immunity The importance of taking astaxanthin with a meal to maximize absorption Why AX3 Astaxanthin surpasses other astaxanthin supplements Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow  Cynthia's Menopause Gut Book is on presale now! Cynthia's Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Connect with Dave Watumull AX3 Life AX3 Life on Instagram

Today, I'm delighted to welcome Dr. Yael Joffe, a leading expert in nutrigenomics who speaks internationally at conferences on translating the science of genetics into clinical practice. She holds a PhD in nutrigenomics from the University of Cape Town, where her research focused on the genetics of obesity. I met Yael earlier this fall and decided to invite her on the podcast to explore the growing field of lifestyle genetics. In our conversation today, we dive into the effects of nutrigenomics, nutrition genetics, and SNPs, which she refers to as spelling changes in our DNA. We cover genetic testing in the industry, red flags, DNA health, and her polygenic approach to weight loss resistance. We also discuss both perimenopause and menopause from the perspective of genetics and epigenetics, and the role of insulin signalling and glucose. Yael's insights are deeply informative. Her pioneering work on 36 metabolic pathways and her ability to make complex genetic information accessible and actionable make this a truly invaluable conversation. IN THIS EPISODE, YOU WILL LEARN: Women and gaining weight after starting HRT Neurotransmitters and what they reveal about mood, anxiety, and addiction tendencies Why do certain people break down dopamine and serotonin either too fast or too slowly? How touch and genuine connection can switch on feel-good genes Sunlight, weather, and environment affect genetic expression. What acupuncture and infrared therapies do at the gene level Why hormones are only part of the picture when addressing midlife weight gain How glucose regulation and insulin sensitivity shift through menopause Dr. Joffe's polygenic testing model connects multiple pathways rather than single genes How Yael's approach to genetic testing differs from that of others in the field Bio: YAEL JOFFE, PhD  Yael is globally recognized as a leading expert in nutrigenomics. In 2000, she was part of the team that built the first lifestyle genetics test, and since then has been responsible for creating many others. She is the author of four books: The Power of Genetics, It's Not Just Your Genes, Genes to Plate, and SNP Journal. Yael has been published in multiple peer-reviewed scientific journals, hosts the Power of Genetics podcast, and is a highly regarded speaker in genetics. Yael built the first online nutrigenomics platform for clinician education and has developed and supervised genomics courses around the world. She has trained thousands of healthcare practitioners globally, also teaching at Rutgers University and the Maryland University of Integrative Health. In 2018, Yael founded 3X4 Genetics and now serves as its Chief Science Officer.    Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community (The Midlife Pause/Cynthia Thurlow)  Cynthia's Menopause Gut Book is on presale now! Cynthia's Intermittent Fasting Transformation Book The Midlife Pause supplement line Connect with Dr. Yael Joffe 3X4 Genetics Instagram Facebook

Welcome to this week's Midlife Minute episode. We're focusing on the importance of having good mental health today. Statistics show that women are experiencing increased anxiety, depression, insomnia, and even suicidal thoughts during midlife, yet the stigma around mental health remains surprisingly strong. Join me as I explore the science behind this, why it's happening, and the importance of empowering yourself to demand better care. IN THIS EPISODE, YOU WILL LEARN: The issues that contribute to the midlife mental health challenges women are experiencing How sleep disruptions in perimenopause increase anxiety, depression, and irritability The metabolic and endocrine factors that can compound mood instability in midlife Why perimenopause is a neurological as well as reproductive transition The evidence-based benefits of HRT for supporting mental health The role of estrogen in brain function and emotional regulation Why HRT is especially important for women experiencing abrupt or early menopause Some practical guidance for using HRT to support mental health Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website. Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow. Cynthia's Menopause Gut Book is on presale now! Cynthia's Intermittent Fasting Transformation Book The Midlife Pause Supplement Line References: Effects of Estradiol Withdrawal on Mood in Women With Past Perimenopausal Depression: A Randomized Clinical Trial (https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2298235)  Efficacy of Estradiol in Perimenopausal Depression: So Much Promise and So Few Answers (https://onlinelibrary.wiley.com/doi/10.1002/da.22391) Effects of Hormone Therapy on Cognition and Mood (https://www.fertstert.org/article/S0015-0282(14)00178-2/fulltext) Does Menopause Hormone Therapy Improve Symptoms of Depression? Findings From a Specialized Menopause Clinic  A Meta-analysis of the Effect of Hormone Replacement Therapy upon Depressed Mood (https://www.sciencedirect.com/science/article/abs/pii/S0306453096000340?via%3Dihub) The Effect of Hormone Replacement Therapy on Cognition and Mood (https://onlinelibrary.wiley.com/doi/10.1111/cen.14856)

We're back with Episode 2 of our Bone Health Masterclass series—and this one is a powerhouse mashup featuring orthopedic surgeon Vonda Wright, magnesium expert Carolyn Dean, researcher Barrie Tan, and bone coach Kevin Ellis. In this dynamic conversation, we break down what really happens to women's bones during menopause—and what you can do about it. You'll learn how strength training, grip strength, and smart fueling directly influence bone density, and finally understand the truth about osteoblasts, osteoclasts, and the constant remodeling happening inside your skeleton. We also go deep on the nutrients that matter most, especially magnesium, the surprising role of melatonin, how chronic stress and gut health impact your bones, and why building bone is about far more than just calcium. Plus, we unpack the science behind OsteoStrong and how targeted loading can stimulate stronger bones at any age. If you care about staying strong, active, and fracture-free for decades to come, this is an episode you can't afford to miss. IN THIS EPISODE, YOU WILL LEARN: Why bone loss accelerates during menopause  How tocotrienols effectively doubled the bone growth-to-loss ratio in osteopenic adults in a clinical trial How relative calorie deficiency, menstrual disruption, and excessive leanness in athletes and non-athletes alike are major, yet underrecognized, risk factors for early osteoporosis Why bone breakdown accelerates when estrogen drops, and how that can be countered How women's bone health has been misunderstood for decades, with an excessive focus on calcium  The critical importance of magnesium, which allows bones to be strong, flexible, and fracture-resistant  The value of melatonin for supporting bone remodeling, promoting osteoblast activity, and protecting bone cells from oxidative stress and inflammation How elevated cortisol from chronic stress directly impairs bone health  Why gut health is foundational to bone health  Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow  Cynthia's Menopause Gut Book is on presale now! Cynthia's Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Connect with Dr. Barrie Tan On his website Instagram Facebook LinkedIn Connect with Dr. Vonda Wright On her website Facebook, Instagram, X, and LinkedIn Leave a message on VIP Phone Number 407-232-2334 Connect with Dr. Carolyn Dean On her website (For educational resources) RnA ReSet Store website Podcast  Magnesium: The Missing Link to Total Health by Dr. Carolyn Dean is available on Amazon  Connect with Kevin Ellis On his website Facebook, Instagram, and LinkedIn Kevin's free Stronger Bones Masterclass  Ep. 234 Metabolic Longevity and Vitamin E with Dr. Barrie Tan Ep. 386 Muscle Strength in Menopause: Key Tests & Lifestyle Measures with Dr. Vonda Wright Ep. 366 Magnesium Masterclass: Unveiling Its Role in Metabolic Function with Dr. Carolyn Dean Ep. 252 How To Optimize Your Bone Health with Bone Coach Kevin Ellis

Today, I am excited to share the first class in a series of lipid masterclasses with the amazing Dr. Thomas Dayspring! Dr. Dayspring is certified in internal medicine and clinical epidemiology and is a fellow of the American College of Physicians and the National Lipid Association. He was previously the Educational Director of a nonprofit organization and has served as the Chief Academic Advisor for two major cardiovascular labs.  Given the in-depth nature of my discussions with Dr. Dayspring over several sessions, each lasting nearly six hours, it seemed logical to present these masterclasses in segments to make them easier to understand. In our first class today, we dive into the fundamentals, exploring what lipids are and how lipids and fatty acids are classified. We cover the physiology and transport of cholesterol and the roles of apoptosis, apo-proteins, and apo-lipoproteins; we unravel the differences between HDL, LDL, IDL, and VLDL; and we explain how to calculate LDL and triglycerides to assess metabolic health. Dr. Dayspring also shares his preferences regarding lab values and indicators that help him assess the early risk of cardiovascular disease. We cover some detailed aspects of physical chemistry in this episode, so I highlight the main clinical points throughout our conversation to make it easier to follow. Be sure to join Dr. Dayspring and me for our next episode in the lipid masterclass series. IN THIS EPISODE YOU WILL LEARN: What are lipids, and why are they important? Dr. Dayspring explains what triglycerides are. How lipids get absorbed and transported throughout the body What lipoproteins are, and how they get classified How cholesterols get calculated The impact of triglycerides on cholesterol levels and cardiovascular health How high triglyceride levels can indicate early insulin resistance or increased ASCVD risk What is the role of HDL particles? How metabolic syndrome impacts cardiovascular health Bio: Thomas Dayspring MD is a Fellow of both the American College of Physicians and the National Lipid Association and is certified in internal medicine and clinical lipidology. After practicing in New Jersey for 37 years, he moved to Virginia in 2012. He served as an educational director for a nonprofit cardiovascular foundation and, until mid-2019, as a Chief Academic Advisor for two major CV laboratories. Since then, he has served as a virtual cardiovascular / lipidology educator. Career-wise he has given over 4000 domestic (in all 50 states) and several international lectures, including over 600 CME programs on atherothrombosis, lipids/lipoproteins (and their treatment), vascular biology, biomarker testing, and women's cardiovascular issues. He has authored several manuscripts and lipid textbook chapters and performed several podcasts. For several years, he was an Associate Editor of the Journal of Clinical Lipidology. He was the recipient of the 2011 National Lipid Association's Presidents Award for services to clinical lipidology and the 2023 Foundation of NLA Clinician/Educator Award. He has over 34K followers on his educational Twitter (X) feed (@Drlipid). He has Gold Heart Member status as a professional member of the American Heart Association and serves as a Social Media Ambassador for the European Atherosclerosis Society and the National Lipid Association. Connect with Cynthia Thurlow Follow on X, Instagram & LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community (The Midlife Pause/Cynthia Thurlow)  Cynthia's Menopause Gut Book is on presale now! Cynthia's Intermittent Fasting Transformation Book The Midlife Pause supplement line Connect with Dr. Thomas Dayspring ⁠Twitter⁠ (@DrLipid) ⁠LinkedIn⁠ ⁠Books written by Gary Taubes⁠ 

I am excited to welcome Dr. Jayne Morgan as my guest today. She is a cardiologist and the Vice President of Medical Affairs at Hello Heart, specializing in women's health and cardiovascular research. In our conversation, we look at the gaps in clinicians' training around perimenopause and menopause, also discussing gender neutral training, and how men and women are treated differently in the medical system. Dr. Morgan shares her preferred areas of focus when educating middle-aged women about hormone replacement therapy and clusters of diagnoses, which include diabetes, dyslipidemia, high blood pressure, and weight-loss resistance. We examine how myocardial infarctions (heart attacks) tend to manifest differently in women, often with microvascular disease, atypical chest pain, and less obvious symptom patterns. We also explore screening recommendations, such as EKGs, Lp(a) assessments, and mammography for microcalcifications, which might indicate an elevated risk for cardiovascular disease. This fun and lively conversation with Dr. Morgan offers valuable, practical insights into women's heart health. I look forward to recording future podcast episodes with her. IN THIS EPISODE, YOU WILL LEARN: One-size-fits-all treatment of women during medical training in the '90s and early 2000s Speaking up in the exam room when something doesn't feel right When hormone therapy was labeled dangerous, and the fallout that followed Medicine's uncomfortable truth: clinicians must keep learning or fall behind Gender-neutral cardiology and the women it left behind The midlife risk-factor pileup no one prepared women for  Why not taking blood pressure or cholesterol medications is risky rather than healthy Heart attacks often mistaken for anxiety, especially in women Slow change, real progress in women's cardiology care Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow  Cynthia's Menopause Gut Book is on presale now! Cynthia's Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Connect with Dr. Jayne Morgan On Instagram, TikTok, Threads, YouTube, and LinkedIn

Today, I'll be unpacking some of the research and science surrounding digestive rest and intermittent fasting.  In this episode, I am transparent about the fact that what works for me now may not be what worked five or ten years ago. I explain what happens in your body when you're not eating, explore ways to approach intermittent fasting, and highlight why your goals, life stage, and metabolic health should guide your choices. Whether you're focused on building muscle, improving metabolic flexibility, or supporting fat loss, I hope that you walk away with a clearer understanding of how long you should go without eating, while honoring your current stage of life. IN THIS EPISODE, YOU WILL LEARN: How everything changed after 10 years of intermittent fasting How digestive rest differs from intermittent fasting Why intermittent fasting works better as a metabolic strategy How digestive rest supports healing The metabolic value of intermittent fasting   How perimenopause and menopause impact the gut microbiome How to determine whether digestive rest or intermittent fasting is more appropriate in different life stages Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow  Cynthia's Menopause Gut Book is on presale now! Cynthia's Intermittent Fasting Transformation Book The Midlife Pause Supplement Line

Welcome to Part 1 of our special bone health mini-series, featuring Dr. Jocelyn Wittstein, Dr. Jessica Shepherd, personal trainer Debra Atkinson, and PhD researcher Dr. Darren Candow. In this episode, we discuss the impact of contraceptive use on bone health, especially in young women, and explore how underfueling and relative energy deficiency can contribute to serious bone health issues early in life. We highlight the strong connection between thyroid health and bone health, and clarify how frequently, how much, and how intensely we should strength train to best support our bones. We examine the potential long-term benefits of vibration plates, address concerns with current osteoporosis screening guidelines, and explain why assessing women's bone health earlier is crucial. Finally, we review the latest research on creatine monohydrate and its promising impact on bone health. I sincerely hope you enjoy Part 1 of this mini-series, which sets the stage for understanding lifelong bone health. IN THIS EPISODE, YOU WILL LEARN: How underfueling, overtraining, and oral contraceptives can limit bone development  The value of strength training and impact-based exercise for preserving bone density, supporting metabolic health, and reducing fracture risk How even a few minutes of impact exercise per day can stimulate bone strength  How vibration plates can complement strength and impact training Why declining estrogen during perimenopause and menopause increases the risk of osteoporosis and fractures as women age The benefits of weight training, resistance exercises, Pilates, and water aerobics for improving bone density and maintaining muscle strength How creatine supplementation combined with resistance training or structured exercise can help preserve bone strength in postmenopausal women How creatine alone, without physical activity, shows no meaningful benefit Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow  Cynthia's Menopause Gut Book is on presale now! Cynthia's Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Connect with Dr. Jocelyn Wittstein On the Duke Health website On Instagram The Complete Bone and Joint Health Plan, co-authored by Jocelyn Wittstein, MD, and Sydney Nitzkorski, MS, RD, is available on Amazon and at Barnes & Noble, and from most bookstores. Connect with Debra Atkinson On her website The Flipping 50 Podcast On Social Media: @flipping50tv Connect with Dr. Jessica Shepherd Sanctum Med and Wellness On Instagram: Jessica Shepherd or Modern Meno Dr. Shepherd's new book, Generation M, is available in-store or online from Barnes and Noble or on Amazon. Connect with Dr. Darren Candow On Instagram On X University of Regina Featured Episodes Ep. 467 Bone & Joint Health Tips for Women 40+ with Jocelyn Wittstein                              Ep. 321 Muscle, Bone & Joint Health in Menopause with Debra Atkinson                    Ep. 424 Menopause 101: Symptoms, HRT, and a Bio-Individual Approach with Dr. Jessica Shepherd Ep. 301 Creatine: The Best Supplement for Better Bones & Brain Health with Dr. Darren Candow

Today, I have the privilege of connecting with Dr. Sara Gottfried! Dr. Sara is a board-certified physician who graduated from Harvard and MIT. She practices evidence-based, integrative, precision, and functional medicine. She is a Clinical Assistant Professor in the Department of Integrative Medicine and Nutritional Sciences at Thomas Jefferson University and Director of Precision Medicine at the Marcus Institute of Integrative Health. She has written four New York Times bestselling books, including her latest, Women, Food and Hormones.  Dr. Sara is one of my favorite doctors in integrative medicine and GYN! In this episode, we dive into the infodemic, how stress impacts hormones, the impact of age-related changes on hormonal regulation, alcohol, and gender differences with ketogenic lifestyles. We discuss some lesser-known hormones, including growth hormone, and how to support them properly. We touch on disordered eating, how trauma influences our relationship with food, epigenetics, and the role of a lifetime relationship with food. We also look at methylation, glutathione, detox reactions, supporting physical detoxification, and our toxic diet culture. I hope you benefit as much from this episode as I did!  IN THIS EPISODE YOU WILL LEARN: Dr. Sara explains what an infodemic is and how it has affected how she communicates with her patients.  What happens to our hormones as we age? The impact of stress on hormone regulation. Dr. Sara busts the myth that testosterone is a male hormone and discusses what testosterone means for women. How does alcohol consumption impact women's hormones? Why do men tend to have an easier time with the ketogenic diet than women? The dramatic changes that occur in women's bodies as they transition from perimenopause to menopause. Looking at the interrelationship between trauma, stress, and autoimmunity. The changes that occur with growth hormones as we age. How trauma affects the genes. How disordered eating impacts metabolism. How to support physical detoxification naturally, without going to extremes. How to address weight-loss plateaus. Connect with Cynthia Thurlow Follow on X, Instagram & LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community (The Midlife Pause/Cynthia Thurlow)  Cynthia's Menopause Gut Book is on presale now! Cynthia's Intermittent Fasting Transformation Book The Midlife Pause supplement line Connect with Dr. Sara Gottfried On her ⁠website⁠ ⁠Facebook⁠, ⁠Instagram⁠ Dr. Sara's books are available on https://www.saragottfriedmd.com/ and ⁠Amazon.⁠

⁠I am delighted to welcome Dr. Andy Galpin today. He is a scientist and tenured professor with a PhD in Human Bioenergetics and an MS in Human Movement Sciences. He has spent the last 20 years focusing on the science and practice of enhancing human performance, in all its forms. He coaches some of the world's highest performers, helping them fulfill their true potential. In our conversation, we dive into women's health during perimenopause and menopause, exploring the impact of estrogen decline on muscle and bone loss, the vital role of resistance training, and the integration of hormone therapy and GLP-1 medications. Dr. Galpin highlights the importance of sleep, offers practical strategies for starting an exercise routine, and shares some research on barriers to women's health. He also addresses overtraining, under-fueling, and the need for an individualized, evidence-based approach for supporting women's health and wellness. Stay tuned for Dr. Galpin's clear guidance on optimizing and maintaining your health through perimenopause, menopause, and beyond. IN THIS EPISODE, YOU WILL LEARN: How estrogen decline impacts women's muscle and bone loss in middle age Why sleep is foundational for recovery, metabolic health, and body composition The importance of resistance training as a lifestyle intervention in midlife How under-fueling undermines your performance and recovery The critical importance of learning movement skills in childhood Strength training tips for middle-aged women Ways to optimize your VO2 Max training How unnecessary rules suggested in fitness messaging can make training less sustainable for many women How hormone therapy and GLP-1 medications can support training and metabolic health Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website. Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow. Cynthia's Menopause Gut Book is on presale now! Cynthia's Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Connect with Dr. Andy Galpin On Instagram and X Absolute Rest Vitality Optima Muscle

We have another short and sweet episode today where I answer questions from listeners in a long-form format.  In this episode, we're focusing on Urolithin A. Stay tuned for more! IN THIS EPISODE, YOU WILL LEARN: An introduction to Urolithin A and what it is A broader role of Urolithin A beyond being “just another supplement.” The gradual decline in cellular energy production that occurs with aging 30–40% of people lack the gut microbes needed to produce sufficient Urolithin A The role Urolithin A plays in supporting and strengthening the gut barrier Impact of declining estrogen during perimenopause and menopause on mitochondrial function Ways Urolithin A enhances mitochondrial health at the cellular level Emerging research linking Urolithin A to brain health, vascular function, and cognitive resilience Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow  Cynthia's Menopause Gut Book is on presale now! Cynthia's Intermittent Fasting Transformation Book The Midlife Pause Supplement Line

Today, I am thrilled to connect with nurse practitioner, Dr. Lisa Chism. Lisa is the Clinical Director of the Oakland Macomb Center for Breast Health in Michigan. She has over 25 years of experience, specializing in breast health, menopause, sexual health, and breast cancer survivorship. She is also an author and a faculty member at a local university. In our conversation, we discuss the breast cancer risk for women with dense breasts, family history, or prior biopsy, diving into supplemental imaging, lifestyle modifications, HRT, and breast risk, and the changes that occur after a breast cancer diagnosis. We also explore the genitourinary syndrome of menopause and screening, permanent versus non-permanent changes occurring in the genital urinary area, and anticipatory informed care guidance for patients with a history of trauma. This is one of those conversations you will definitely want to revisit. With Lisa's thoughtful advocacy, deep commitment to patient care, and powerful insights, it is clear why sharing her message is so critically important. IN THIS EPISODE, YOU WILL LEARN: The different levels of breast density and their implications for cancer detection Various risk assessment tools used to determine breast cancer risk  How alcohol impacts the risk of breast cancer  Why weight management essential for post-menopausal women The importance of having detailed conversations with providers about menopause symptoms and the available treatment options Lisa shares her approach to evaluating and educating patients  How trauma impacts women's sexual health Permanent and non-permanent changes that occur in the vaginal area during menopause Can older women still do HRT? A simple breast-examination habit for all women Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow  Cynthia's Menopause Gut Book is on presale now! Cynthia's Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Connect with Dr. Lisa Chism Instagram (@DrMommyPoppins) Instagram (@TheAdoptedNurse)  Oakland Macomb OBGYN Center for Breast Health-Rochester Hills

Step into the world of metabolic health and fasting as we embark on a captivating journey with the renowned Canadian clinical educator, Megan Ramos! In an era when chronic illness and obesity have become alarmingly prevalent, and dieting has become a lifelong struggle for many, Megan is on a mission to revolutionize our understanding of metabolic health. Known for her expertise in therapeutic fasting and low-carb diets, she co-founded the revolutionary Fasting Method alongside the renowned Dr. Jason Fung and co-authored the bestselling book Life in the Fasting Lane. Now, she returns with her latest work, delving into the untold stories of women and fasting.  In today's captivating discussion, Megan and I explore the staggering statistics that reveal a nation plagued by chronic illness and weight issues, where even the average person has tried 126 diets in their lifetime. Megan shares her groundbreaking insights on women and fasting, unveiling the truth behind misdiagnoses, the myths surrounding intermittent fasting, the role of macros and insulin secretion, and the profound impact of the pandemic on our hormones, sleep, and stress levels.  Prepare yourself for a thought-provoking episode as we tackle pressing questions from listeners, covering the dawn effect, gout, insomnia, and invaluable strategies for achieving fasting success! IN THIS EPISODE YOU WILL LEARN: My journey with PCOS Why does body composition matter so much? PCOS, the number one endocrine disorder in Westernized countries Common myths about intermittent fasting The fertility aspect of postmenopausal women The slippery slope of perimenopause Is fasting just an extreme form of calorie restriction? The impact of sleep and stress on glucose and insulin levels How to integrate intermittent fasting into your lifestyle Magnesium supplementation for insulin resistance How to deal with gout Connect with Cynthia Thurlow Follow on X, Instagram & LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community (The Midlife Pause/Cynthia Thurlow)  Cynthia's Menopause Gut Book is on presale now! Cynthia's Intermittent Fasting Transformation Book The Midlife Pause supplement line Connect with Megan Ramos ⁠The Fasting Method⁠ Find Megan on social media @Megan J. Ramos Purchase a copy of⁠ ⁠⁠Life in the Fasting Lane⁠  Purchase a copy of⁠ ⁠⁠The Essential Guide to Intermittent Fasting For Women⁠ Previous Episodes Featuring Megan ⁠Ep. 116 – Using Intermittent Fasting to Reverse Chronic Illnesses – with Megan Ramos⁠ ⁠Ep. 188 – Troubleshooting Your Fasting Method with Megan Ramos

Today, I am delighted to welcome Dr. Karan Rajan, a gastroenterologist, author, and one of the most prominent health and science creators on social media, with a large and engaged social media following. In our discussion today, we delve into the evolution of fiber, exploring it as a previously overlooked micronutrient, and discussing its chemistry, biology, and the roles of fiber polyphenols, prebiotics, and GLP-1s. We look at satiety and various hormones, and Dr. Rajan shares his take on the increase we're seeing in colorectal cancer. He also clarifies why colonoscopies are safe screening modalities, how women's guts change in midlife, and various other topics, including poop, the Goldilocks effect, the estrobolome, polypharmacy, microplastics, estrogen dominance, medical myopia, and the gut-brain axis. Join us for today's incredibly informative and information-packed podcast with Dr. Karan Rajan. IN THIS EPISODE, YOU WILL LEARN: Why is fiber so important? How fiber fuels the microbiome Some examples of high-fiber foods How fiber and polyphenols support microbial and hormonal balance How fiber supports our endogenous GLP-1 ecosystem Why colonoscopy risks are often misunderstood How perimenopause alters gut motility and appetite What constipation really means  How lifestyle factors like sleep, exercise, sunlight, and medications shape the microbiome Dr. Rajan debunks some common social media misconceptions surrounding the gut-brain axis. Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow  Cynthia's Menopause Gut Book is on presale now! Cynthia's Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Connect with Dr. Karan Rajan On the Loam website  Instagram and YouTube On other social media: @drkaranrajan

We have another short-form, live YouTube episode today, where I dive into questions from listeners. Recently, the most frequently asked questions have been about cholesterol, likely because I often reference my podcast series with Dr. Tom Dayspring, a renowned lipidologist and menopause expert. Join me today to clear away some more of the confusion surrounding cholesterol. IN THIS EPISODE, YOU WILL LEARN: Why comprehensive lipid testing rather than standard testing is essential, post-menopause How menopause impacts women's lipid and triglyceride levels The roles APO B and Lp(a) play in assessing cardiac risk How the cardiac risk of women increases as estrogen declines The cardiac health benefits of monitoring lipids and considering HRT within the first six years of menopause What research studies reveal about how menopause influences cardiovascular risk Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow  Cynthia's Menopause Gut Book is on presale now! Cynthia's Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Episodes with Dr. Thomas Dayspring: Episode 336: Lipid Masterclass: An Introduction to Lipids and Cholesterol with Dr. Thomas Dayspring Episode 344: Lipid Masterclass: A Deep Dive into Our Cardiovascular Needs with Thomas Dayspring Episode 352: Lipid Masterclass: Apo-B, Labs and Women's Heart Health with Thomas Dayspring Episode 495: Are You At Risk for Dementia? – The Most Overlooked Cholesterol Marker You Need to Know with Dr. Thomas Dayspring

I am honored to connect with Dr. Neil Nathan today. Dr. Nathan has been practicing medicine for over 50 years. He is board-certified in family medicine and pain management, a founding diplomat of the American Board of Integrative Holistic Medicine, and a founding member of the International Society for Environmentally Acquired Illness. He is also a published author and has recently released an updated and expanded version of his book, Toxic: Heal Your Body from Mold Toxicity, Lyme Disease, Multiple Chemical Sensitivities, and Chronic Environmental Illness. In our discussion, we explore various complex medical illnesses and the effects of mold, chronic inflammation, immunosenescence, and genetics on the immune system, vagus nerve, and limbic system. We discuss mold exposure and colonization, and what that means for midlife women, along with MCAS, Lyme disease, and mast cell degranulation, and we examine Epstein-Barr as a symptom rather than a primary driver. We also cover limbic and vagal retraining, and Dr. Nathan shares his systematic approach to supporting the adrenal glands and to detoxification efforts in treatment. This episode with the renowned Dr. Neil Nathan is like a mini masterclass on complex medical illnesses. I found his book super-informative and probably the most systematic source I've ever read on mold, Lyme, and complex medical problems. IN THIS EPISODE, YOU WILL LEARN: • How our current medical system fails to support complex patients • How limited appointment times prevent root-cause investigation • What mold colonization means and why its location in the body matters • Why leaving a moldy environment does not always resolve symptoms • How Epstein-Barr often signals immune dysfunction rather than causing it • Why limbic retraining is essential in today's world • Dr. Nathan shares his systematic approach to adrenal support  • Practical steps to support liver, gut, kidney, and lymphatic detoxification • Why addressing mold and Candida must precede SIBO treatment Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community (The Midlife Pause/Cynthia Thurlow)  Cynthia's Menopause Gut Book is on presale now! Cynthia's Intermittent Fasting Transformation Book The Midlife Pause supplement line Connect with Dr. Neil Nathan On his website

I am excited to connect with Dr. Lara Briden today! She is one of my favorite naturopathic doctors and the author of the bestselling books Period Repair Manual and Hormone Repair Manual. She has 25 years of experience in women's health, and she currently has consulting rooms in Christchurch, New Zealand, where she treats women with PCOS, PMS, endometriosis, perimenopause, and many other hormone- and period-related health problems. Dr. Briden is a wealth of information! She brings a fresh perspective and a positive voice to the health and wellness space, and I often recommend her book, Hormone Repair Manual, to my clients and patients.  Today, she and I dive into her background as an evolutionary biologist and discuss how she became passionate about supporting and advocating for women throughout their lives. We talk about perspectives on aging, what the second puberty (perimenopause) is, and the impact of histamine, mass-cell granulation, and estrogen. We discuss fat redistribution in middle age and the loss of insulin sensitivity. We speak about how using alcohol impacts brain health, sleep, the gut microbiome, appetite, cravings, and hinders estrogen metabolism. We also touch on ways to address dysfunctional uterine bleeding in middle age, explain how to advocate for your health, how middle age impacts the nervous system, and the role of inflammatory foods, including dairy.  I hope you enjoy our discussion as much as I did! Stay tuned for more! IN THIS EPISODE YOU WILL LEARN: Dr. Briden discusses her background as an evolutionary biologist and how she changed her career to become an advocate for women's health. Many women fear the aging process. Dr. Briden and I discuss women's mindsets and perspectives on aging.  Why is there so little awareness about perimenopause? Dr. Briden defines menopause and discusses the timeframe in which some women experience perimenopause symptoms. How can ongoing hormonal fluctuations during perimenopause, or second puberty, increase the likelihood of women having issues with a histamine response? Dr. Briden talks about fat redistribution in middle age and explains why women need to stay on top of it from a metabolic perspective. How can our modern-day lifestyle make the metabolic shift women experience in menopause even more challenging? Dr. Briden talks about natural treatments and hormone therapies to lighten the flow of the extremely heavy periods that some women experience during perimenopause. Dr. Briden discusses the connection between cow dairy and an inflammatory reaction in some people. Women need to understand what happens in their bodies when they have either a partial or a full hysterectomy. Dr. Briden talks about estrogen and brain health. How does alcohol affect the body? What are the best options with the fewest side effects for hormone therapy for women? Connect with Cynthia Thurlow Follow on X, Instagram & LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community (The Midlife Pause/Cynthia Thurlow)  Cynthia's Menopause Gut Book is on presale now! Cynthia's Intermittent Fasting Transformation Book The Midlife Pause supplement line Connect with Dr. Lara Briden On her ⁠website⁠   ⁠Facebook⁠, ⁠Instagram⁠, and Twitter: ⁠https://twitter.com/LaraBriden⁠  Dr. Briden's ⁠blog⁠  Dr. Briden's ⁠podcast⁠ Books mentioned: ⁠Period Repair Manual ⁠(for women in their 20s and 30s) by Dr. Lara Briden ⁠Hormone Repair Manual⁠ (for women of 40-plus) by Dr. Lara Briden Free ⁠download⁠ of the first two chapters of both Dr. Lara Briden's books ⁠The XX Brain: The Groundbreaking Science Empowering Women to Maximize Cognitive Health and Prevent Alzheimer's Disease⁠ by Lisa Mosconi, PhD

Today, I'm honored to connect with Jerry Wise, a leading voice in family systems and self-differentiation. With over 45 years of experience healing adults from narcissistic, dysfunctional, and emotionally immature family systems, Jerry's work guides people out of lifelong patterns of guilt, shame, and emotional enmeshment so they can finally live as their true selves. This episode is not about telling anyone what they should do with their family relationships. It's about understanding patterns, reclaiming choice, and recognizing that protecting your nervous system is essential for your wellness. We dive into narcissism, personality disorders, and the spectrum within which Jerry believes narcissism falls. We explore low, middle, and high-anxiety family systems, clarify why self-differentiation is critically important, and how long-term nervous system dysregulation often occurs when we grow up in narcissistic homes. We also cover trauma bonding, the impact of avoidance, the role of boundaries, and cultural myths around honoring our parents, and I answer some rapid-fire questions tailored explicitly to Jerry's expertise. I have wanted to interview Jerry for the podcast for a long time, and this is one of those truly impactful and deeply personal episodes. IN THIS EPISODE, YOU WILL LEARN: How narcissistic parents differ from other types of parents The developmental switches that get turned off in those growing up with narcissistic parents Intergenerational trauma and how it impacts nervous system regulation and emotional health How self-differentiation can help individuals manage their emotional systems Challenges of setting boundaries with narcissistic parents Why internal boundaries are essential How avoidance can become a coping mechanism for dealing with uncomfortable feelings The importance of maintaining reality and not giving up on your true self to honor your parents and/or meet their expectations Strategies for managing family dynamics and reducing chronic anxiety Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow  Cynthia's Menopause Gut Book is on presale now! Cynthia's Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Connect with Jerry Wise On his website  Instagram, TikTok, Facebook, and YouTube

Today, we have another episode in the YouTube series where I answer listeners' questions from the Everyday Wellness Podcast and my private free Facebook group, The Midlife Pause/Cynthia Thurlow. We're continuing the conversation around hair loss today. In the last episode, we covered some common causes of hair loss. In this episode, we discuss how nutrition can either positively or negatively affect it. Some familiar themes come up again, but they're hard to avoid because in midlife, nutrition is not optional. It's essential! IN THIS EPISODE, YOU WILL LEARN: Why a protein-centric diet is vital in middle age  How over-fasting can exacerbate hair loss Why iron is essential for hair growth Foods that are beneficial for their polyphenols and antioxidants Why metabolic health is critical for hair follicle protection How stress and disrupted sleep affect hair loss The value of weight training and maintaining muscle mass  The role of iodine, selenium, and red blood cell magnesium in hair growth and the benefits of an anti-inflammatory diet Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow  Cynthia's Menopause Gut Book is on presale now! Cynthia's Intermittent Fasting Transformation Book The Midlife Pause Supplement Line

Today, I'm thrilled to welcome Meghan Rabbitt as my guest. Meghan is an award-winning journalist and the author of The New Rules of Women's Health: Your Guide to Thriving at Every Age. She specializes in women's health and wellness, and her work has appeared in several national publications, including Oprah Daily, Prevention, Maria Shriver's Sunday Paper, and others.  Meghan is known for translating and clarifying complex medical and scientific topics into actionable information. In our conversation today, we dive into her new book and explore the process of writing a 700-page guide. We discuss how the old rules of women's health have often failed, and Meghan shares her hope that things will shift. We cover underrecognized midlife issues such as heart disease, the power of knowledge, reframing the aging process, and how the lack of research funding and a paternalistic system contributed to the lack of information on how women's bodies age.  We also examine the influence of social media, navigating the medical system, advocacy, the gut-brain-hormone connection, and the crucial role of fiber, and Meghan emphasizes why every woman's story matters.  Meghan's book is incredibly valuable, as it speaks to women of all ages, from young adults to those in later life. IN THIS EPISODE, YOU WILL LEARN: Why personal context matters when following nutrition advice on social media The value of seeking multiple clinician opinions when facing health choices Improving your communication with clinicians to help them understand your priorities and concerns An essential approach to diet and lifestyle  Underrecognized midlife issues, like heart disease, and why they are often overlooked in women's health How midlife changes in estrogen are linked with alterations in the microbiome and astrobolome Understanding the gut-brain-hormone connection can help clarify your symptoms and guide your lifestyle choices. Gut health and why fiber is important Knowledge, advocacy, and reframing aging empower women to navigate the medical system and make better-informed decisions Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow  Cynthia's Menopause Gut Book is on presale now! Cynthia's Intermittent Fasting Transformation Book The Midlife Pause supplement line Connect with Meghan Rabbitt On The New Rules of Women's Health website Purchase a copy of Meghan's new book

I am delighted and honored to interview Dr. Lisa Mosconi today. She is an Associate Professor of Neuroscience in neurology and radiology at Cornell Medicine and Director of the Women's BRAIN Initiative and the Alzheimer's Prevention Clinic at Weill Cornell Medicine, New York Presbyterian Hospital. She is also a globally acclaimed neuroscientist with a Ph.D. in neuroscience and nuclear medicine and the author of the New York Times bestseller The XX Brain and, more recently, The Menopause Brain. In our conversation, we discuss how women's brains change during perimenopause and menopause, looking at the significance of puberty, pregnancy, and perimenopause, as well as the lack of medical research on women and medical gaslighting. We explore the concept of bikini medicine and its misconceptions regarding women's health and hormones, alongside the crucial roles of hormones like estradiol, progesterone, and testosterone in our neuroendocrine system. Dr. Mosconi also provides insights into evolving menopausal treatments, including lifestyle interventions.  Dr. Mosconi is an esteemed figure in neuroscience and a prominent voice in women's health. I am confident you will gain valuable insights and perspectives from my discussion with her today. IN THIS EPISODE YOU WILL LEARN: How women's brains change during perimenopause and menopause How the lack of information for young girls can lead to medical gaslighting and confusion during perimenopause Dr. Mosconi explains how a simple sugar is used as a tracer to track glucose metabolism in the brain during perimenopause Why brain changes during menopause may lead to mental fatigue and brain fog How the lack of training and research on menopause in medical residency programs leads to a poor understanding among clinicians Why women need to consider their brain and metabolic health during perimenopause Why estrogen is essential after menopause The benefits of HRT for menopausal women How stress impacts hormone production Connect with Cynthia Thurlow Follow on X, Instagram & LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community (The Midlife Pause/Cynthia Thurlow)  Cynthia's Menopause Gut Book is on presale now! Cynthia's Intermittent Fasting Transformation Book The Midlife Pause supplement line Connect with Dr. Lisa Mosconi On her ⁠website⁠ ⁠Instagram⁠ The Menopause Brain

I'm delighted to welcome Dr. Doug Lucas today for the second episode of a two-part masterclass on bone health. He is double board-certified as both an orthopedic surgeon and an osteoporosis specialist, and he is on a mission to prove to the world that osteoporosis is both preventable and reversible. We continue our conversation, discussing bone health issues and diving into standards of care for osteopenia and osteoporosis. Dr. Doug unpacks the impact of drug therapies, from bisphosphonates to anabolics and lifestyle factors. We cover atypical fractures, mandibular necrosis, the challenges of hypermobility, and ways to support stability and training. Dr. Doug also breaks down osteogenic loading and training, clarifies why supplements are only as effective as your nutrition, and debunks common myths around bone health, mobility, and strength training. You will not want to miss this valuable and informative masterclass with Dr. Doug Lucas. It is jam-packed with helpful insights, so you will likely want to listen to it more than once. IN THIS EPISODE, YOU WILL LEARN: The importance of personalizing supplements  Why it's essential to check your biomarkers before supplementing The specific minerals and vitamins that are important for bone health Why supplements should never replace foundational nutrition and lifestyle work How boron and fat-soluble vitamins benefit bone health The importance of personalizing your supplement plan  How targeted testing and fewer supplements can yield better results How osteoporosis can improve and, in many cases, be reversed   How peptides and GLP-1s impact bone health and muscle preservation The role of lifestyle, nutrition, and exercise in bone health Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community (The Midlife Pause/Cynthia Thurlow)  Cynthia's Menopause Gut Book is on presale now! Cynthia's Intermittent Fasting Transformation Book The Midlife Pause supplement line Connect with Dr. Doug Lucas The OsteoCollective Community The Dr. Doug Show

Today, I answer the next round of listener questions, both from the podcast and those I've been asked to address more personally on YouTube. Join me for this episode, where we dive into an honest and authentic exploration through the lens of traditional, allopathic medicine, of why women lose their hair during perimenopause and menopause. IN THIS EPISODE, YOU WILL LEARN: Why hair loss is often multifactorial and requires a comprehensive approach How declining estradiol impacts the hair follicle cycle Why hair growth slows and shedding increases as estrogen declines The typical pattern of how hair loss presents in middle-aged women How low or fluctuating thyroid hormone levels can increase hair loss The importance of checking ferritin levels, even in women who are not overtly anemic How insulin resistance, glycemic variability, and inflammation contribute to hair loss Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow  Cynthia's Menopause Gut Book is on presale now! Cynthia's Intermittent Fasting Transformation Book The Midlife Pause Supplement Line

Today, I am honored to welcome my personal trainer, Linda Alexander, as my guest. Linda has been training middle-aged and older women almost exclusively for the last decade of the 40 years she has spent in personal training. In our conversation, we explore the challenges of training middle-aged women. Linda highlights the importance of strength training over cardiovascular exercise, and we discuss the way my elementary school physical education teacher approached physical fitness for children many years ago. Linda explains how she evaluates new clients through movement and exercise progression, shares her personal view on intermittent fasting, and clarifies how it can contradict muscle building and maintenance. We also explore the importance of mindset and keeping nutrition simple, and we dive into many listener questions, ranging from progressive overload to nutrition and workouts.  This conversation with my personal trainer is truly impactful, one that many of you have been asking for. I know you will enjoy it as much as I did while recording it. IN THIS EPISODE, YOU WILL LEARN: How women's nutritional needs and exercise tolerance change at different life stages How to control your carbohydrate intake without necessarily being ketogenic Linda shares her approach to strength training How our mindsets and self-expectations influence strength training experience How functional movement can help older adults maintain their independence and prevent falls Why combining a ketogenic diet with cardio can hinder achieving the results you want The benefits of eating protein before or after exercise The importance of staying well-hydrated and taking supplements to support your energy and recovery How celebrating small wins and practicing self-kindness can strengthen your mindset and improve your long-term progress Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community (The Midlife Pause/Cynthia Thurlow)  Cynthia's Menopause Gut Book is on presale now! Cynthia's Intermittent Fasting Transformation Book The Midlife Pause supplement line Connect with Linda Alexander On her website ⁠Instagram⁠ and⁠ Facebook⁠

I am thrilled to have Dr. Ken Berry joining me on the podcast for the third time today. He was with me before on episodes 111 and 139. Dr. Berry is a physician, best-selling author, and passionate health advocate with a no-nonsense approach to health and wellness. He has been practicing at the Berry Clinics since 2003 and is an active community member. He has written two books, Lies My Doctor Told Me and the recently published Kicking Ass After Fifty, in addition to various other resources, including Common Sense Labs Today. He also has a YouTube channel, serving over 2 million subscribers- one of my favorite go-to resources for my patients.  In our conversation today, we dive into the latest Lancet research on the impact of a diabetes diagnosis on life expectancy, along with insights from the American Diabetes Association regarding the costs of diabetes care. We discuss the need for proper diagnostic modalities to identify insulin resistance earlier and the labs Dr. Berry uses in his practice for identifying those at risk. We explore the recently recognized American Heart Association syndrome, CKM (Cardiovascular Kidney Metabolic Syndrome), and the role of GLP agonists, continuous glucose monitors, and glucometers. Dr. Berry also shares his views on plant-based diets, proper diets, and more.  IN THIS EPISODE YOU WILL LEARN: Why does metabolic health continue to deteriorate in most of the general population?  The staggering amount of disposable plastic used within the healthcare industry The importance of fasting insulin levels when diagnosing metabolic disease Why are blood tests essential for determining metabolic health? The benefits of glucometers and continuous glucose monitors for metabolic health How Dr. Berry's health improved after following a specific diet and measuring his lab results for a month How misinformation gets spread within the health and wellness industry Why are doctors not informing their patients about the absence of long-term studies and deluding them with false information? The long-term effects of Semaglutide on the body  How a proper diet can naturally lower lipid levels The limitations of the germ model for treating chronic diseases  Connect with Cynthia Thurlow Follow on X, Instagram & LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community (The Midlife Pause/Cynthia Thurlow)  Cynthia's Menopause Gut Book is on presale now! Cynthia's Intermittent Fasting Transformation Book The Midlife Pause supplement line Connect with Dr. Ken Berry On ⁠YouTube⁠ ⁠Instagram⁠, ⁠Facebook⁠ ⁠Twitter⁠ Dr. Berry's books ⁠Lies My Doctor Told Me⁠  ⁠Kicking Ass After 50⁠    ⁠Common Sense Labs⁠  Dr. Berry's Private Community ⁠Phdhealth.community⁠ Medical News article Mentioned ⁠Here's What to Know About Cardiovascular-Kidney-Metabolic Syndrome, Newly Defined by the AHA ⁠  Previous Episodes Featuring Dr. Ken Berry ⁠Ep. 111 – Is The Keto Diet The Proper Human Diet? – with Dr. Ken Berry⁠ ⁠Ep. 139 – Hyperinsulinemia: What You Should Know About This National Health Crisis with Dr. Ken Berry

Today, I am thrilled to connect with Dr. Kellyann Niotis, a fellowship-trained preventive neurologist specializing in risk reduction strategies for neurodegenerative disorders. Dr. Niotis completed her medical internship and neurology residency at New York-Presbyterian Weill Cornell Medical Center. She is passionate about preventive neurology, especially as it relates to advocacy, policy changes, and improving access to care and education. In our discussion, we explore the memory changes and brain fog that occur during perimenopause, and the fear of neurocognitive changes. We look at screening, testing, and labs, examine the effects of alcohol on brain health, and how estrogen is often framed as a reproductive hormone despite its role as a brain fuel regulator. We also clarify why caring for ourselves in midlife is essential for our long-term brain health, outlining the risk factors for neurocognitive changes, the role of neuroplasticity, and how lifestyle factors and loneliness collectively impact brain health and longevity. This is an exciting and evolving area of neurology, and I am truly grateful to share Dr. Niotis's expertise and insights with the Everyday Wellness community. IN THIS EPISODE, YOU WILL LEARN: How hormone fluctuations in perimenopause impact women's cognition and brain function The early signs that can help us distinguish menopausal cognitive changes from age-related decline or Alzheimer's How sleep quality (not just duration) profoundly affects neurocognitive health How vascular health and cholesterol influence long-term risk for cognitive decline and dementia How neuroplasticity and lifestyle interventions can support ongoing brain adaptation Why hearing loss is a major, under-recognized modifiable risk factor for dementia The value of exercise, especially high-intensity interval training, for growing new brain cells How estrogen and progesterone affect women's brain health  Why too much data tracking can harm your brain health Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow  Cynthia's Menopause Gut Book is on presale now! Cynthia's Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Connect with Kellyann Niotis Instagram Website

We have another Midlife Minute episode today, dedicated to a single theme, where I answer listener questions one at a time in a concise and focused format. Join me today as we dive into HRT and sleep issues. IN THIS EPISODE, YOU WILL LEARN: How persistent vasomotor symptoms can continue to disrupt sleep, even once hormone levels are optimized Different types of hormones and delivery methods can impact sleep quality. Why we tend to get sleepy earlier in the evening and wake up earlier in the morning as we age Estrogen and progesterone impact sleep quality in different ways. How chronic underlying stress, anxiety, and mood issues impact sleep quality The value of cognitive behavioral therapy and structured insomnia interventions Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow  Cynthia's Menopause Gut Book is on presale now! Cynthia's Intermittent Fasting Transformation Book The Midlife Pause Supplement Line

I am honored to be joined today by James Swanwick, a renowned stop-drinking expert and author of Clear: The Only Neuroscience-Based Approach for High Achievers to Quit Drinking Without AA, Rehab, or Willpower. He is a former SportsCenter anchor on ESPN and the creator and founder of the Stop Drinking Process. In today's personal and thought-provoking conversation, James and I talk about alcohol use disorder, exploring how family dynamics and early environments shape our drinking habits, how alcohol use becomes normalized, the perceived benefits of drinking, and the very real health risks and consequences. James explains why alcohol is considered one of the most harmful drugs, how younger generations are approaching alcohol differently, the role of peer pressure in an alcohol-free lifestyle, and the importance of gratitude. Join us for an insightful and informative discussion on why we drink, how to reframe our relationship with alcohol, and for those who are sober-curious, a stepwise approach to making that shift. IN THIS EPISODE, YOU WILL LEARN: How family dynamics and early environments shape our relationship with alcohol How alcohol becomes normalized long before we ever take our first drink The real cost of using alcohol as a social lubricant How the health consequences of alcohol show up as we age Where alcohol ranks among the most harmful drugs Why appropriate accountability and community matter more than willpower The importance of structured support when quitting alcohol How gratitude, reframing, and daily practices can reduce cravings and support lasting change Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow  Cynthia's Menopause Gut Book is on presale now! Cynthia's Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Connect with James Swanwick On Instagram Alcohol-free Lifestyle Alcohol-free Lifestyle on YouTube Alcohol-free Lifestyle Podcast CLEAR: The Only Neuroscience-Based Method for High Achievers to Quit Drinking Without Willpower, Rehab, or AA

We're back with another episode in a series of highly vetted companies that I love sharing with my community. Today, I'm joined by Forrest Smith, the co-founder and CEO of Kineon. A dynamic entrepreneur with an infectious enthusiasm for his work, Forrest reads and writes fluent Chinese, lives in Mexico, and brings over 20 years of experience building and scaling successful startups. His work at Kineon reflects his optimism and innovative approach in the field of health and wellness technology. In our conversation, we explore what red light therapy (photobiomodulation) is and its cellular and mitochondrial effects. We unpack the benefits of methylene blue, the impact of photobiomodulation on joint pain and thyroid health, and specific contraindications. We also discuss red light therapy and the gut hormone access, peptides, recovery toolkits, and female-centric research related to infertility, PCOS, endometriosis, thyroid health, and more. This is one of those conversations you will likely want to listen to more than once. Be sure to check the show notes for a special offer from Kineon, exclusively for my listeners. IN THIS EPISODE, YOU WILL LEARN: What is red light therapy? How red light therapy supports the body at the cellular level, particularly during the aging process How methylene blue enhances the effects of red light therapy The value of photobiomodulation for treating chronically inflamed joints and muscle tissue How local inflammation in the joints impacts gut health The benefits of red light therapy for female-specific pathologies, such as endometriosis, hypothyroidism, and dysmenorrhea The way that red light therapy works in combination with stem cell treatments, PRP, and extracorporeal shock wave therapy Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow  Cynthia's Menopause Gut Book is on presale now! Cynthia's Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Connect with Forrest Smith Kineon Kineon Labs on Instagram We're giving away TWO Kineon Move+ Pro devices (worth $499 each!) Want to enter? Leave a review of the Everyday Wellness podcast in English on Apple Podcasts or Spotify.  Take a screenshot of your review. Email the screenshot and one reason why you'd like to win to podcast@cynthiathurlow.com (You must live in the U.S. to enter.)

Today, I am thrilled to connect with Dr. Will Bulsiewicz, a board-certified gastroenterologist, gut health authority, and New York Times bestselling author with an upcoming book called Plant Powered Plus.  In our discussion today, we examine the gut-immune connection, looking at how inflammation affects the gut microbiome and gut barrier, and how technology and lifestyle impact our health. We discuss the limitations of conventional allopathic medical approaches to disease, the telltale signs that inflammation may underlie your gut-related symptoms, why fiber is the longevity nutrient, and the critical importance of short-chain fatty acids. We also explore the food matrix, changes in perimenopause and menopause regarding fiber intake, the significance of lipopolysaccharides and circadian biology, and how fiber can improve your sleep quality.  This episode is truly a must-listen. I thoroughly enjoyed connecting with Dr. B. I have admired his work for years, and his new book is one you will want to buy for its insights and your enjoyment. IN THIS EPISODE, YOU WILL LEARN: Lifestyle changes that are essential for preventing and managing chronic diseases The importance of fiber for chronic disease prevention How fiber feeds the gut microbes  Why women need more fiber during perimenopause and menopause Why you need to increase your fiber intake gradually How fermented foods support microbiome diversity and reduce inflammation How gut barrier leaks can trigger immune activation and inflammation How circadian rhythm disruptions affect the microbiome The value of consistent fiber intake for better sleep quality Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community (The Midlife Pause/Cynthia Thurlow)  Cynthia's Menopause Gut Book is on presale now! Cynthia's Intermittent Fasting Transformation Book The Midlife Pause supplement line Connect with Dr. Will Bulsiewicz On his website Preorder a copy of Plant Powered Plus

We have another episode today where I answer questions from my podcast listeners, providing more details than I usually would in the podcast. I genuinely hope you're enjoying these short-form videos and podcasts. I'd love to know which topics you'd like me to cover in this YouTube format, where I can dive a little deeper into your questions. Please share your thoughts! IN THIS EPISODE, YOU WILL LEARN: What our ability to eat fiber reflects about the health of our microbiome How hormonal changes in midlife influence women's weight patterns and metabolic flexibility How declining estrogen during perimenopause and menopause affects the gut microbiome How fiber can indirectly support weight loss  How fiber helps maintain gut barrier integrity and reduces systemic inflammation Why middle-aged women need more protein  The role the strobilome plays in supporting estrogen recycling and gut detoxification  Practical strategies for increasing fiber intake safely and sustainably Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow  Cynthia's Menopause Gut Book is on presale now! Cynthia's Intermittent Fasting Transformation Book The Midlife Pause Supplement Line

Today, we have the second episode of a two-part mashup series focused on weight-loss resistance.  For today's episode, I am delighted to welcome experts Dr. Mary Claire Haver, Dr. Rocio Salas-Whalen, and Physician's Assistant McCall McPherson.  Dr. Haver and I explore how inflammation drives weight gain and unpack specific strategies for macronutrients, meal timing, and more. Dr. Salas-Whalen and I examine body composition changes during perimenopause and menopause, our family responsibilities, the importance of strength training for maintaining muscle mass, and the targeted use of GLP-1 agonist drugs. Finally, McCall and I break down the labs that help guide decision-making, also discussing informed consent, the effects of hormonal replenishment therapy (now known as personalized endocrine treatment), the strategic use of GLP-1s, personalized dosages, and microdosing. This mashup includes many timely and relevant insights from three experts at the forefront of women's health. Join us as we explore the science, strategies, and solutions shaping the future of weight loss resistance. IN THIS EPISODE, YOU WILL LEARN: How slowing sugar absorption reduces insulin spikes and inflammation The value of combining healthy fats, complex carbs, and lean protein at every meal  Why spreading protein intake throughout the day is crucial for metabolism, hormone regulation, and muscle preservation How prioritizing self-care and modeling it for children helps break the cycle of parental over-sacrifice Why strength training is more effective than cardio for long-term body composition and metabolic health The mounting stress, family pressures, and reduced self-care that many women face in their 40s and 50s How synthetic hormones in oral contraceptives disrupt thyroid, testosterone, and reproductive hormones How GLP-1 agonists can improve weight loss, food freedom, and metabolic flexibility How supporting adrenal health enhances energy, balances hormones, and improves metabolic flexibility Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community (The Midlife Pause/Cynthia Thurlow)  Cynthia's Menopause Gut Book is on presale now! Cynthia's Intermittent Fasting Transformation Book The Midlife Pause supplement line Connect with Dr. Mary Claire Haver On her website Instagram and TikTok The Galveston Diet Book Ep. 308 Weight Gain in Middle Age, Perimenopause and Inflammation with Mary Claire Haver Connect with Dr. Rocio Salas-Whalen On her website Instagram Ep. 384 Why Weight Loss is Complex: Obesity's Multi-Factorial Nature with Dr. Rocio Salas-Whalen Connect with McCall McPherson Modern Thyroid Clinic On Instagram and TikTok Modern Thyroid and Wellness Podcast Thyroid Lab Guide Ep. 282 Thyroid Health: Hormones, Medications & Weight Loss with McCall McPherson

I am delighted to reconnect with Dr. Jason Fung today. We last connected in October 2020 for Episode 121.  Dr. Fung is a nephrologist and a prominent figure in the intermittent fasting and low-carb space. He has made significant contributions as a founding member of The Fasting Method, providing evidence-based guidance on weight loss and blood glucose management through low-carb diets and intermittent fasting. He has written several books, including The Obesity Code, The Complete Guide to Fasting, The Diabetes Code, and The Cancer Code.  In our discussion today, we look at the forecast for metabolic health in 2024, exploring how the growth of the diabetes population relates to the effects of the pandemic and addressing the conflict of interest with organizations like the ADA and registered dieticians. Dr. Fung shares some of his biggest frustrations, including the shallow and myopic thinking amongst those focusing on calories in and calories out, and we get into various facets of metabolic health, from the nuanced influences of gender, puberty, perimenopause, and menopause to hedonistic eating, sarcopenia, bio-individuality, and therapeutic fasting. Dr. Fung also shares his perspective on GLP-1s, shiftwork, supplements, and more. Join us for valuable insights on various aspects of metabolic health and how they impact our well-being. IN THIS EPISODE YOU WILL LEARN How the influence of food companies has led dieticians and diabetes associations to focus on moderation instead of a balanced diet Dr. Fung shares his frustration with the lack of progress in addressing the diabetes issue How hormones impact weight gain and hunger Why does focusing on calories in and out not provide the solution to weight loss? How intermittent fasting can help to control hormonal issues How middle-aged women need to find balance when fasting to maintain muscle mass and avoid sarcopenia How intermittent fasting can lead to increased strength despite losing muscle mass  What causes shift workers to gain weight? The potential drawbacks of using GLP-1 drugs for weight loss Why magnesium deficiency is a common problem in modern society Connect with Cynthia Thurlow Follow on X, Instagram & LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community (The Midlife Pause/Cynthia Thurlow)  Cynthia's Menopause Gut Book is on presale now! Cynthia's Intermittent Fasting Transformation Book The Midlife Pause supplement line Connect with Dr. Jason Fung ⁠Website⁠ ⁠Twitter ⁠and ⁠YouTube⁠ ⁠The Fasting Method⁠ Dr. Fung's ⁠books⁠ Previous Episode Featuring Dr. Jason Fung ⁠Ep. 121 – The Truth About Diabetes, Kidney Disease and Insulin Resistance with Dr. Jason Fung⁠

Today, I'm thrilled to reconnect with Dr. Rocio Salas-Whalen, a board-certified endocrinologist and obesity medicine specialist with more than 15 years of clinical experience, widely recognized as one of the earliest adopters of GLP-1 therapies in the United States. She is also the author of the upcoming book Weightless: A Comprehensive Guide to the New Era of GLP-1 Medications. In our discussion, we explore the transgenerational impact of obesity as a complex, chronic, and deeply multifactorial condition. We discuss the effects of environmental exposures and trauma, the essential role of education in overcoming weight-loss resistance and managing obesity, and the physiological changes women experience in the perimenopause-to-menopause transition. We explain the importance of body positivity and image, reframing our thoughts around obesity and being overweight, and why building and maintaining muscle is non-negotiable. We dive into the physiology of GLP-1 medications and specific targets for women in perimenopause and menopause, ways to address weight-loss stalls, and the effects of the weight bias so deeply entrenched in our society. Dr. Salas Whalen also shares her thoughts on alternatives and additions to GLP-1 therapies, clarifying the importance of protein and strength training while using GLP-1 drugs.  This conversation with Dr. Salas-Whalen is truly invaluable, and I highly recommend her upcoming book, Weightless. IN THIS EPISODE, YOU WILL LEARN: • What people come to understand about “normal eating” after starting GLP-1s • How GLP-1s interrupt the binge–guilt–shame cycle • The role GLP-1s play in helping people stay in control of food rather than letting food control them • Strategies for avoiding side effects when using GLP-1 medications • Why certain foods trigger problems on injection days • Importance of proper guidance to prevent severe side effects • The impact a prescriber's guidance has on your success with GLP-1s • Why treatment plans must be tailored to each patient's needs and metabolism • Factors doctors consider when deciding whether to add additional medications to a GLP-1 plan Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community (The Midlife Pause/Cynthia Thurlow)  Cynthia's Menopause Gut Book is on presale now! Cynthia's Intermittent Fasting Transformation Book The Midlife Pause supplement line Connect with Dr. Rocio Salas-Whalen Website On social media: @drsalaswhalen Dr. Rocio's Book, Weightless - Pre-order now! (Releases 12-30-25)

We have another AMA episode today, where I answer some of the most frequently asked podcast listener questions. In response to a question from Catherine, we unpack the timing hypothesis in this episode, exploring the cardiovascular nuances and clarifying why individualized care truly matters. IN THIS EPISODE, YOU WILL LEARN: Cardiovascular and metabolic benefits of starting hormone therapy within about 10 years of menopause onset What the timing hypothesis really means in clinical practice Why feeling better does not necessarily imply long-term disease risk has been reduced How endothelial (blood vessel) health influences the effectiveness of hormone therapy  Why metabolic changes after menopause matter more than most women realize How their hormone therapy decisions must change as women move further beyond menopause  Risks and benefits of oral versus transdermal hormone delivery Value of shared patient-clinician decision-making  How lifestyle habits and risk assessment form the foundation for safe, effective, and personalized hormone therapy decisions Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow  Cynthia's Menopause Gut Book is on presale now! Cynthia's Intermittent Fasting Transformation Book The Midlife Pause Supplement Line

Today, I am honored to connect with doctors Andy Lazris and Alan Roth, the authors of A Return to Healing. Dr. Lazris, a physician practicing geriatric primary care medicine in Maryland, is a Certified Medical Director who orchestrates medical care and provides education for several long-term care facilities. Dr Roth is a physician, practicing family medicine and palliative care in New York. He is the Chairman of the Department of Family Medicine and Ambulatory Care at MediSys Health Network.  In our discussion, we explore the impact of the Flexner Report, including how it has reshaped our medical system and clinical guidelines, expanded the definition of disease, and influenced critical thinking. Drs. Lazris and Roth explain how challenging established medical dogma becomes even more problematic within a Flexnerian framework. They examine the prevalence of ineffective and costly procedures, the manipulation of research studies, the role of documentation in medical literature, and the impact of terms like non-compliant and histrionic on the quality of patient care. They also clarify what actually happens with screening measures and how patients can find excellent care.  Their book, A Return to Healing, is truly a love letter to their communities. It is a must-read for anyone seeking to understand the complexities of our current medical system and how it has gotten derailed. IN THIS EPISODE, YOU WILL LEARN: Why doctors should question dogma and think critically rather than just following medical guidelines How medical training encourages standardized testing and discourages nuanced and patient-centered thinking How our profit-driven system rewards procedures and prescriptions over proper patient care Why drugs can sometimes cause more harm than good, and how elderly patients often suffer due to overprescribing How drug companies manipulate statistics to make small benefits seem huge Why patient noncompliance can often mean informed refusal rather than ignorance or defiance How biased medical documentation may unfairly target women and minorities Modern fast-food-type medicine and eroding trust within the doctor–patient relationship Why shared decision-making is meaningless in a system built on one-size-fits-all dogma Protecting yourself within a dysfunctional medical system Connect with Cynthia Thurlow  Follow on X, Instagram & LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community (The Midlife Pause/Cynthia Thurlow)  Cynthia's Menopause Gut Book is on presale now! Cynthia's Intermittent Fasting Transformation Book The Midlife Pause supplement line Connect with Dr. Andy Lazris and Dr. Alan Roth On their⁠ website⁠ Email Dr. Lazris: ⁠alazris50@gmail.com ⁠ Email Dr. Roth: ⁠aroth@jhmc.org ⁠   

I am delighted to have my good friend and fan-favorite, Dr. Tabatha Barber, join me again to share her wisdom on the podcast!  Dr. Tabatha is a triple board-certified OB/GYN specializing in menopause and functional medicine. She has a wonderful podcast called The Gutsy Gynecologist Show and is often referred to affectionately as the Gutsy Gynecologist. Dr. Tabatha was with me in two previous podcast episodes, ⁠#206⁠ and ⁠#212⁠, and both are in the top twenty downloaded podcasts in the last 18 months! Many women suffer unnecessarily when going through perimenopause and menopause. Dr. Tabatha and I have an AMA (Ask Me Anything) episode today. We discuss weight gain related to perimenopause and menopause, issues with estrogen replacement therapy, how many different factors can impact libido, how to address a partial hysterectomy and HRT, and bioidenticals versus synthetic hormones. We also get into lab work, skin reactions relative to perimenopause and menopause, emotional eating, leptin resistance, and many other topics.  I'm grateful for all the great questions and have no doubt this episode with Dr. Tabatha will be another fan-favorite! IN THIS EPISODE YOU WILL LEARN: Why do too much estrogen and too little estrogen both cause weight gain?  How fragrances and plastic contribute to the imbalance between estrogen and progesterone. How changing to organic tampons and pads, or using a Diva cup, can be a game-changer for women. Should women who have had a partial hysterectomy and are on HRT still check progesterone and testosterone levels and fast like a post-menopausal female? Dr. Tabatha shares her thoughts on plain estradiol versus Biest and Triest. Dr. Tabatha offers her recommendations for a healthy 48-year-old female with zero libido. What can a 17-year-old with high testosterone do to get her testosterone level within the normal range? Is there a biological or mindset issue at play if you never feel full and always want to eat, irrespective of how healthy or satisfying the foods you eat are? The benefits of fasting.  What can we do to support our pelvic joints? How do our hormones affect our skin? Connect with Cynthia Thurlow Follow on X, Instagram & LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community (The Midlife Pause/Cynthia Thurlow)  Cynthia's Menopause Gut Book is on presale now! Cynthia's Intermittent Fasting Transformation Book The Midlife Pause supplement line Connect with Dr. Tabatha Barber On her ⁠website⁠ ⁠The Gutsy Gynecologist Show⁠ ⁠Episode 206 Pt 1: A Deep Dive into Perimenopause- Hormonal Imbalances and Birth Control with Dr. Tabatha Barber⁠ ⁠Episode 212 Pt. 2: A Deep Dive into Hormonal Imbalances and Menopause with Dr. Tabatha Barber⁠ Books mentioned: ⁠The XX Brain⁠ by Lisa Mosconi

I am thrilled to reconnect with Dr. Sanjay Bhojraj today. Dr. Bhojraj is a board-certified interventional cardiologist who became a pioneer in functional medicine. In our conversation, we dive into palpitations, which are a common complaint among perimenopausal and menopausal women. We explore red flag symptoms, the physiological effects of progesterone, estrogen, and testosterone as they relate to heart arrhythmias, EKG changes during the perimenopause-to-menopause transition, and wearable technologies. We unpack the differences between benign and more concerning arrhythmias, risk factors for atrial fibrillation, and the process of taking a thorough history, ordering the correct tests, and using imaging or sleep studies when appropriate. We cover treatment pathways, from lifestyle modifications to medications, channelopathies, and the genetic propensities for conditions such as Long QT, Brugada Syndrome, WPW (Wolff-Parkinson-White syndrome), and sudden cardiac death. We also highlight the importance of genetic testing for individuals with a family history of those conditions. Today's conversation with Dr. Sanjay Bhojraj is full of practical wisdom and clinical pearls, so you will most likely want to listen to it more than once. IN THIS EPISODE, YOU WILL LEARN: Why thyroid function should always be taken into account when assessing heart rhythm issues   How stress and life circumstances can trigger palpitations  The benefits of magnesium supplementation for supporting heart health What ventricular arrhythmias (from the bottom chambers) and atrial arrhythmias (from the top chambers) are commonly related to The value of monitoring for identifying the nature and severity of arrhythmias How sleep apnea can increase the risk of arrhythmia   The importance of exercise, stress management, and healthy lifestyle habits for supporting heart rhythm Why certain arrhythmias may require procedural interventions Why various types of athletic activity matter when evaluating arrhythmias How genetic factors can impact specialized heart assessments Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community (The Midlife Pause/Cynthia Thurlow)  Cynthia's Menopause Gut Book is on presale now! Cynthia's Intermittent Fasting Transformation Book The Midlife Pause supplement line Connect with Dr. Sanjay Bhojraj On his website On social media: @DoctorSanjayMD The Curious Cardiologist Podcast

I am dedicating today's entire episode to colonoscopies.  When I had my fifth colonoscopy yesterday, I shared the before-and-after experience online and received a flood of responses. Healthcare professionals thanked me for the transparency, while many followers admitted they were anxious, postponing their own procedures, or worried about the small likelihood of complications.  With my own strong family history of precancerous polyps and years of firsthand experience, I wanted to dive deeper so I can speak from both knowledge and empowerment. Join me as I unpack the facts to dispel your fears and bring a sense of calm confidence to this potentially life-saving procedure. IN THIS EPISODE, YOU WILL LEARN: How the rising incidence of colorectal cancer in younger women has led to a need for earlier detection  How colorectal cancer symptoms often get misattributed to stress, perimenopause, hemorrhoids, or other hormonal changes The risk factors of colonoscopies Various types of colonoscopy prep  How colonoscopy prep impacts the gut microbiome How probiotics can help reduce post-colonoscopy GI symptoms What women need to know about sessile serrated polyps How perimenopause and menopause alter colorectal cancer risk in women What major clinical trials reveal about prevention and long-term protection Some alternatives to traditional colonoscopy Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow  Cynthia's Menopause Gut Book is on presale now! Cynthia's Intermittent Fasting Transformation Book The Midlife Pause supplement line Research Links: Risk of colorectal cancer seven years after flexible sigmoidoscopy screening: randomised controlled trial  Once-only flexible sigmoidoscopy screening in prevention of colorectal cancer: a multicentre randomised controlled trial Effect of Colonoscopy Screening on Risks of Colorectal Cancer and Related Death Response: Re: Mobile Phone Use and Brain Tumors in Children and Adolescents: A Multicenter Case–Control Study Once-Only Sigmoidoscopy in Colorectal Cancer Screening: Follow-up Findings of the Italian Randomized Controlled Trial—SCORE  Blood Test Could Provide Colonoscopy Alternative for Colorectal Cancer Screening Alteration in gut microbiota after colonoscopy: proposed mechanisms and the role of probiotic interventions Adverse events related to colonoscopy: Global trends and future challenges 

Today, I am delighted to connect with Dr. Sameena Rahman, a board-certified OBGYN and certified menopause practitioner with over a decade of expertise in midlife sexual medicine and concierge gynecology. Dr. Rahman founded the GSM Collective in downtown Chicago to deliver a more personalized patient-first model of health care for women.  In our conversation, we explore how cultural and racial factors influence care for women, particularly during the menopausal transition. We discuss the heart disease risk of women with a baseline of inflammation and insulin resistance, the effects of allostatic load on minority women, why cognitive health is crucial, the impact of alcohol, and why the current medical model is a systemic failure that gaslights women. We also examine the impact of pelvic floor therapy, appropriate pelvic examinations, specific autoimmune vulvar conditions, and how oral contraceptives affect sexual health, and Dr. Rahman shares her recommendations for preventing frailty and loss of independence. I am a big admirer of Dr. Rahman's work and look forward to having her join us again after her new book is published. IN THIS EPISODE, YOU WILL LEARN: Why Hormone Replacement Therapy alone might not solve all menopausal genital issues How pelvic floor issues can even affect women who have not given vaginal births What a routine Pap smear can miss, regarding vulvar and vestibular health What a simple Q-tip test can reveal about vulvar pain How untreated pain can create a cycle of pelvic floor problems How local hormone therapy can target vulvar and vestibular pain where systemic hormones may fall short The benefits of trauma-informed exams  The value of integrating pelvic floor therapy with local hormone treatment  How long-term birth control use might affect vulvar tissue What to consider for balancing contraception with sexual health Bio: Dr. Sameena Rahman Dr. Sameena Rahman is a board-certified OB/GYN, sex-med gynecologist, menopause specialist, and a clinical assistant professor of OB/GYN at the Northwestern Feinberg School of Medicine.  She is the founder of the GYN & Sexual Medicine Collective, a successful concierge practice that emphasizes evidence-based medicine, and an affiliate of Ms. Medicine. Dr. Rahman is dedicated to evaluating and treating each patient with compassion, trauma-informed care, and an awareness of personal bias. Additionally, she hosts the podcast Gyno Girl Presents: Sex, Drugs & Hormones and will release her first book, Brown Girls Disease? A Guide To Sexual Health and Empowerment through a South Asian Lens in 2026.  Connect with Cynthia Thurlow   Follow on⁠ X⁠,⁠ Instagram⁠ &⁠ LinkedIn⁠ Check out Cynthia's⁠ website⁠ Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community ⁠(The Midlife Pause/Cynthia Thurlow⁠)⁠ ⁠ Cynthia's⁠ Menopause Gut Book⁠ is on presale now! Cynthia's⁠ Intermittent Fasting Transformation⁠ Book ⁠The Midlife Pause supplement line⁠ Connect with Dr. Sameena Rahman The GSM Collective Dr. Sameena Rahman on Instagram (@gynogirl) Gyno Girl Presents Sex, Drugs and Hormones (Podcast) Resources Find a practitioner to assist with your sexual concerns The International Society for Vulvo Vaginal Diseases The National Vulvodynia Association Prosayla (Female Sexual Health Education)

Today, I am privileged to connect with Sal Di Stefano. Sal is a sought-after fitness and health expert with a straightforward, uncomplicated communication style. He is also a co-host of the immensely popular Mind Pump Podcast. In our discussion, we explore why the scale is an ineffective measure of success in our culture, particularly for women. We dive into the effects of body image and dysfunctional relationships with our bodies, contrasting self-hate patterns with self-love patterns. We look at ways to train differently in middle age with the challenges of perimenopause and menopause, and consider the impact of physiological changes during pregnancy and the postpartum period. We also cover signs of overtraining and intuitive nutrition and address many listeners' questions about reverse dieting, hormetic strategies, and authenticity.  I am sure you will love this conversation, and I look forward to having Sal back on the show in 2024. IN THIS EPISODE YOU WILL LEARN: The limitations of relying solely on weight as a measure of success in health and wellness Why we should focus on the full scope of fitness and diet rather than a specific number or metric How patterns of self-hatred can lead to unhealthy behaviors  How to practice self-care with exercise and a healthy diet Why exercise routines should be founded on factors like sleep, stress, fitness levels, and diet The importance of starting with small, manageable steps toward self-care and weight loss Why strength training is the most effective exercise for women in perimenopause and menopause How high-performing athletes prioritize recovery and rest to prevent burnout and injury Post-pregnancy muscle recruitment patterns and exercises Diet and nutrition for improved mental clarity and physical performance The benefits of strength training for muscle growth and hormone balance Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community (The Midlife Pause/Cynthia Thurlow)  Cynthia's Menopause Gut Book is on presale now! Cynthia's Intermittent Fasting Transformation Book The Midlife Pause supplement line Connect with Sal Di Stefano On ⁠YouTube⁠ ⁠Mind Pump Podcast

Today, I am delighted to reconnect with my friend and colleague, Dr. Mindy Peltz, a New York Times bestselling author and a leading voice in women's health, hormones, and aging. She has written several books, with her most recent being Age Like A Girl. She also has a top-ranking podcast and YouTube channel.  In our conversation today, we'll explain how you can reframe menopause as an evolutionary upgrade. We dive into the neurochemical shifts that occur in menopause, exploring Carol Gilligan's work, the purpose of menopause, the influence of the Gen X generation, and how trauma influences our perimenopause and menopause experiences. We unpack the role of oxytocin, clarify why clutter is problematic, and discuss the effects of environmental psychology. We also highlight the critical importance of bioindividuality at this stage of life, and Dr. Mindy shares the books she likes and recommends. This discussion with Dr. Mindy is personal and deeply philosophical, inviting you to contemplate ideas that will continue to resonate with you long after it ends. IN THIS EPISODE, YOU WILL LEARN: How setting boundaries improves relationships and preserves energy in midlife Why children transitioning to adulthood must be allowed to handle responsibilities How parental over-involvement can hinder the independence of young adults How the neurochemical shifts in perimenopause and menopause alter women's emotional responses and priorities The value of novelty and new experiences for supporting mental and emotional health How clutter impacts stress levels, especially during hormonal changes The benefits of creating calm environments to regulate the brain and emotional system How downsizing can bring profound peace and freedom Why solitude and personal space are essential for self-regulation in midlife How menopause creates the need for recalibrating relationship boundaries Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community (The Midlife Pause/Cynthia Thurlow)  Cynthia's Menopause Gut Book is on presale now! Cynthia's Intermittent Fasting Transformation Book The Midlife Pause supplement line Connect with Dr. Mindy Pelz On⁠ YouTube⁠ ⁠Age Like A Girl (Website)⁠ ⁠Pre-order a copy of Age Like A Girl

I am honored to have Dr. Tom Dayspring join me again today for another AMA session. He and I have done eight podcasts before, and this is a continuation of our last Ask Me Anything episode.  Dr Dayspring is an esteemed expert on internal medicine and clinical lipidology. He is likely one of the most influential worldwide lipid experts, so I am thrilled to have him back with me to dive into various topics related to listener questions, including the impact of hormone replacement therapy on lipid changes, methods of administration, and why bioidentical hormone replacement therapy is preferable for managing both menopausal symptoms and lipid health. We discuss medications, including PCSK9 inhibitors and GLP-1s, as well as intermittent fasting, lipids, and cardiovascular disease risk. We also examine how heart disease develops gradually, over time, the impact of stress and lifestyle, and Dr. Dayspring shares the labs he recommends beyond traditional lipids, ApoB, and LpA. In our discussion, Dr. Dayspring noted that he was not in a position to speak about GLP-1 therapies or microdosing. Since I received many questions from listeners on those topics, I will host a future solo AMA to address some of their concerns. Today's conversation with Dr. Tom Dayspring is truly invaluable, and I trust you will walk away with valuable insights you can share with your healthcare providers. We created a PDF - cynthiathurlow.com/lipids -  specifically for listeners that outlines key labs to discuss with your providers and questions to ask them to help you advocate for your own health and your family members' health. IN THIS EPISODE, YOU WILL LEARN: Why being physically fit does not always eliminate the risk of heart problems arising How ApoB and cholesterol contribute to heart disease over decades Why the early testing of risk factors is essential How chronic stress increases the risk of heart disease  How high cortisol affects insulin sensitivity and glucose regulation How stress impacts endothelial and nitric oxide function The link between low Omega-3 levels and heart problems How insulin resistance degrades heart health How high homocysteine levels can impair endothelial function and contribute to cardiovascular problems Connect with Cynthia Thurlow   Follow on⁠ X⁠,⁠ Instagram⁠ &⁠ LinkedIn⁠ Check out Cynthia's⁠ website⁠ Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community ⁠(The Midlife Pause/Cynthia Thurlow⁠)⁠ ⁠ Cynthia's⁠ Menopause Gut Book⁠ is on presale now! Cynthia's⁠ Intermittent Fasting Transformation⁠ Book ⁠The Midlife Pause supplement line⁠ Connect with Dr. Thomas Dayspring On X (@DrLipid) On LinkedIn

We have another episode in a series of discussions with well-vetted guests from companies that I feel my community would benefit from hearing about Today, I speak with Dr. Stephanie Venn Watson, a veterinary epidemiologist and the co-founder and co-CEO of Serafina Therapeutics. She has worked with the World Health Organization, DARPA, and the US Navy. She has over 70 patents and has authored more than 80 peer-reviewed scientific papers, and her discoveries have featured on NPR, Science Friday, BBC, NBC, and National Geographic. Her groundbreaking discoveries around the health benefits of C15:0 are the topic of a recent book. In our conversation today, we explore longevity molecules and geno-protective molecules, why they matter, and how they work. We cover the basics of rapamycin and glucophage, then dig into the growing body of research on longevity and lifespan, specifically looking at C15:0, what it is, what it does, why it's important, and how it's the first essential fatty acid discovered in decades. We look at its wide-ranging pleiotropic effects on metabolic health, mood, sleep, the brain, gut, and immunity, as well as the signs of low C15:0 levels and the specific labs that can identify a deficiency. We also talk about the benefits of supplementation and improved bioavailability.  Since I have been taking C15:0 myself over the last four to five months and noticed improvements in my recovery and sleep, I'm excited to share this informative and helpful conversation, humbly dedicated to the essential saturated fatty acid, C15:0. IN THIS EPISODE, YOU WILL LEARN: • The role C15:0 plays in guiding the aging process and new findings about its benefits for the immune  system, brain, and longevity • C15:0's emerging importance as a key player in metabolic balance • What Dr. Venn-Watson's animal studies revealed about the mechanisms of aging in humans • Why women in midlife become more vulnerable to shifts in immune quality and cellular resilience • The ways nutritional deficiencies can appear in blood markers long before symptoms develop • What occurs with red blood cell stability and aging markers when C15:0 levels are too low • Which biomarkers are now being considered early indicators of biological aging • Formulation features of C15:0 that enhance its bioavailability • The multiple bodily systems that can benefit from supplementing with C15:0 Connect with Cynthia Thurlow   Follow on ⁠X⁠, ⁠Instagram⁠ & ⁠LinkedIn⁠ Check out Cynthia's ⁠website⁠ Submit your questions to ⁠support@cynthiathurlow.com⁠ Join other like-minded women in a supportive, nurturing community (The Midlife Pause/Cynthia Thurlow) ⁠https://www.facebook.com/groups/themidlifepause⁠ Cynthia's ⁠Menopause Gut Book ⁠is on presale now! Cynthia's ⁠Intermittent Fasting Transformation⁠ Book ⁠The Midlife Pause supplement line⁠ Connect with Dr. Stephanie Venn-Watson ⁠Fatty 15⁠ ⁠Discover C15:0⁠ ⁠Seraphina Therapeutics⁠ On⁠ LinkedIn⁠

Today, I am delighted to welcome Dr. William Davis, a cardiologist and New York Times bestselling author of the Wheat Belly series. He is also the author of Undoctored, Super Gut, and his latest book, Super Body. In our conversation, we dive into the toxic diet industry and how it profits from repeatedly delivering wrong messages. We explore physiological changes in body composition that contribute to poor metabolic health and inflammation, the dangers of ectopic fat, and the influence of our environment. Dr. Davis explains the weight loss Ponzi scheme and how muscle loss drives changes in body composition. We also unpack the gut-muscle axis, the role of the microbiome in muscle building, SIBO and treatment options, and examine the broader effects of oxytocin on body composition, touching on the benefits of replacing lost biological compounds, like collagen and hyaluronic acid, the impact of Max, the microbiota, and accessible carbs, along with practical takeaways to support healthier living and better body composition. This conversation with Dr. Will Davis is incredibly insightful, and I look forward to having him back to discuss the female and vaginal microbiomes. IN THIS EPISODE, YOU WILL LEARN: The specific probiotic strain that influenced body composition in a clinical trial The benefits of fiber for your metabolism and fat distribution The role of collagen and hyaluronic acid in joint, skin, and vascular health How animal-based fibers affect the microbiome differently from plant fibers The value of fermented foods for cultivating beneficial gut microbes The long-term risks of restrictive diets  How declining estrogen alters immune function in women The lasting impact of antibiotics and past treatments on gut microbiota How to prepare your gut for a thriving microbial ecosystem The surprising effects of foundational probiotic interventions on mood and social behavior Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Connect with Dr. William Davis On his website  YouTube Blog Defiant Health (Podcast) Books

I am thrilled to reconnect with Nick Norwitz today. Nick is a researcher and educator with a mission to make metabolic health a mainstream concern. He graduated valedictorian from Dartmouth College, completed his PhD in metabolism at the University of Oxford, and earned his MD at Harvard Medical School. He has become known as a clinical researcher and metabolic health educator, speaking and writing on various topics, including brain health, microbiome, mitochondrial function, cholesterol, and more.  In our conversation, we discuss the challenges of providing evidence-based medicine, and Nick shares his personal story of overcoming inflammatory bowel disease with a ketogenic diet. We explore the research on statins reducing endogenous GLP-1 production, highlighting the importance of staying curious. We also clarify the different types of type 2 diabetes, the effects of biomolecular aging, and different perspectives on Lp(a).  Nick always provides thoughtful and valuable insights on a range of topics. His Substack is one of my favorites, sharing several ways to enhance your learning process, as a clinician or a layperson. IN THIS EPISODE, YOU WILL LEARN: How his struggle with inflammatory bowel disease led Nick to realize that the evidence-based care of western medicine is not always the best type of care, and how a ketogenic diet saved his life How a recent study highlighted several major physical issues statins cause, yet it went largely unnoticed in medicine and the media The need for clinicians to inform their patients about the potential side effects of their medications How physicians tend to ignore evidence in favor of one-sided messaging that erodes trust and undermines informed care The importance of remaining curious and acknowledging that what you learned initially might be incorrect How technological advances will make personalized medicine the future of healthcare The limitations of traditional one-size-fits-all randomized controlled trials The sub-phenotypes of type 2 diabetes How enzyme inhibitors (like statins) disrupt the gut microbiome How metabolic health and oxidative stress affect Lp(a), and how vitamin C can potentially reduce its impact Bio: Nick Norwitz Nick Norwitz, MD, PhD, is a researcher-educator whose mission is to “Make Metabolic Health Mainstream.” He graduated Valedictorian from Dartmouth College, majoring in Cell Biology and Biochemistry, before completing his PhD in Metabolism at the University of Oxford and his MD at Harvard Medical School.  Nick has made a name for himself as a clinical research and metabolic health educator, speaking and writing on topics ranging from brain health, the microbiome, and mental health to muscle physiology, mitochondrial function, and cholesterol and lipids. His mantra is “Stay Curious.” Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Connect with Nick Norwitz On YouTube, X, and Instagram His Substack