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Class of animals with milk-producing glands

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搞乜咁科學 GMG Science
搞乜咁科學 #33 - 一個人生B與叻過Chat GPT Making Baby DIY & Outsmarting AI

搞乜咁科學 GMG Science

Play Episode Listen Later Mar 17, 2025 60:46


歡迎嚟到 搞乜咁科學 GMG Science 第33集!今集嘅主題係《一個人生B與叻過ChatGPT Baby Making DIY & Human Outsmarting AI》

Pop Culture Pastor
Watch-alongs: Mammalian Nurturables (Severance S2 E3)

Pop Culture Pastor

Play Episode Listen Later Feb 3, 2025 52:17


University of Minnesota Press
Our shared needs connect us: Writers respond to the science of animal conservation.

University of Minnesota Press

Play Episode Listen Later Jan 21, 2025 44:16


Humans are one species on a planet of millions of species. The literary collection Creature Needs is a project that grew out of a need to do something with grievous, anxious energy—an attempt to nourish the soul in a meaningful way, and an attempt to start somewhere specific in the face of big, earthly challenges and changes, to create a polyvocal call to arms about animal extinction and habitat loss and the ways our needs are interconnected. The book's editors, Christopher Kondrich, Lucy Spelman, and Susan Tacent, are joined here in conversation.More about the book: Creature Needs is published in collaboration with the nonprofit organization Creature Conserve. The following writers contributed new literary works inspired by scientific articles: Kazim Ali, Mary-Kim Arnold, Ramona Ausubel, David Baker, Charles Baxter, Aimee Bender, Kimberly Blaeser, Oni Buchanan, Tina Cane, Ching-In Chen, Mónica de la Torre, Tongo Eisen-Martin, Thalia Field, Ben Goldfarb, Annie Hartnett, Sean Hill, Hester Kaplan, Donika Kelly, Robin McLean, Miranda Mellis, Rajiv Mohabir, Kyoko Mori, David Naimon, Craig Santos Perez, Beth Piatote, Rena Priest, Alberto Ríos, Eléna Rivera, Sofia Samatar, Sharma Shields, Eleni Sikelianos, Maggie Smith, Juliana Spahr, Tim Sutton, Jodie Noel Vinson, Asiya Wadud, Claire Wahmanholm, Marco Wilkinson, Jane Wong.About the editors:Christopher Kondrich, poet in residence at Creature Conserve, is author of Valuing, winner of the National Poetry Series, and Contrapuntal. His writing has been published in The Believer, The Kenyon Review, and The Paris Review.Lucy Spelman is founder of Creature Conserve, a nonprofit dedicated to combining art with science to cultivate new pathways for wildlife conservation. A zoological medicine veterinarian, she teaches biology at the Rhode Island School of Design and is author of National Geographic Kids Animal Encyclopedia and coeditor of The Rhino with Glue-On Shoes.Susan Tacent, writer in residence at Creature Conserve, is a writer, scholar, and educator whose fiction has been published in Blackbird, DIAGRAM, and Tin House Online.Episode references:The Lord God Bird by Chelsea Steubayer-Scudder in Emergence MagazineThinking Like a Mountain by Jedediah Purdy in n+1Praise for the book:A thought-provoking and emotionally resonant read that stands out for its lyrical prowess and formal innovation, making it a significant contribution to contemporary literature as well as a key volume bridging the gap between the worlds of science and art.”—Library JournalCreature Needs: Writers Respond to the Science of Animal Conservation is available from University of Minnesota Press.

Kottke Ride Home
The Oldest Mammalian Ancestor Discovered, an Update on the Flight of the Parker Solar Probe & TDIH: Howdy Doody Premiers on NBC

Kottke Ride Home

Play Episode Listen Later Dec 28, 2024 17:09


On today's episode; the oldest mammalian ancestor is discovered, an update on the flight of the Parker Solar Probe, plus, on 'This Day in History', the show that would influence children's television for generations to come -- Howdy Doody. World's oldest mammalian ancestor discovered in Mallorca This dog-like predator is the oldest known mammal ancestor | Popular Science Early–middle Permian Mediterranean gorgonopsian suggests an equatorial origin of therapsids | Nature Communications TDIH: Norb's Corner: “It's Howdy Doody time!” TDIH: 1947: NBC Introduces Howdy Doody on 'Puppet Playhouse Presents' From Doodyville to Detroit: The History of Howdy Doody, a Legendary Show of the Golden Age of TV Contact the show - coolstuffcommute@gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Bob Enyart Live
Evolution's Big Squeeze

Bob Enyart Live

Play Episode Listen Later Nov 21, 2024


* List of Discoveries Squeezing Evolution: Did you know that dinosaurs ate rice before rice evolved? That turtle shells existed forty million years before turtle shells began evolving? That insects evolved tongues for eating from flowers 70 million years before flowers evolved? And that birds appeared before birds evolved? The fossil record is a wonderful thing. And more recently, only a 40,000-year squeeze, Neanderthal had blood types A, B, and O, shocking evolutionists but expected to us here at Real Science Radio! Sit back and get ready to enjoy another instant classic, today's RSR "list show" on Evolution's Big Squeeze! Our other popular list shows include: - scientists doubting Darwin - evidence against whale evolution - problems with 'the river carved the canyon' - carbon 14 everywhere it shouldn't be - dinosaur still-soft biological tissue - solar system formation problems - evidence against the big bang - evidence for the global flood - genomes that just don't fit - and our list of not so old things! (See also rsr.org/sq2 and rsr.org/sq3!) * Evolution's Big Squeeze: Many discoveries squeeze the Darwinian theory's timeframe and of course without a workable timeframe there is no workable theory. Examples, with their alleged (and falsified) old-earth timeframes, include: - Complex skeletons existed 9 million years before they were thought to have evolved, before even the "Cambrian explosion".- Butterflies existed 10 million years before they were thought to have evolved. - Parrots existed "much earlier than had been thought", in fact, 25 million years before they were thought to have evolved. - Cephalopod fossils (squids, cuttlefish, etc.) appear 35 million years before they were able to propagate. - Turtle shells 40 million years before turtle shells began evolving - Trees began evolving 45 million years before they were thought to evolve - Spores appearing 50 million years before the plants that made them (not unlike footprints systematically appearing "millions of years before" the creatures that made them, as affirmed by Dr. Marcus Ross, associate professor of geology). - Sponges existed 60 million years before they were believed to have evolved. - Dinosaurs ate rice before it evolved Example - Insect proboscis (tongue) in moths and butterflies 70 million years before previously believed has them evolving before flowers. - Arthropod brains fully developed with central nervous system running to eyes and appendages just like modern arthropods 90 million years earlier than previously known (prior to 2021, now, allegedly 310mya) - 100 million years ago and already a bird - Fossil pollen pushes back plant evolution 100 million years. - Mammalian hair allegedly 100-million-years-old show that, "the morphology of hair cuticula may have remained unchanged throughout most of mammalian evolution", regarding the overlapping cells that lock the hair shaft into its follicle. - Piranha-like flesh-eating teeth (and bitten prey) found pushing back such fish 125 million years earlier than previously claimed   - Shocking organic molecules in "200 million-years-old leaves" from ginkgoes and conifers show unexpected stasis. - Plant genetic sophistication pushed back 200 million years. - Jellyfish fossils (Medusoid Problematica :) 200 million years earlier than expected; here from 500My ago. - Green seaweed 200 million years earlier than expected, pushed back now to a billion years ago!  - The acanthodii fish had color vision 300 million years ago, but then, and wait, Cheiracanthus fish allegedly 388 million years ago already had color vision. - Color vision (for which there is no Darwinian evolutionary small-step to be had, from monochromatic), existed "300 million years ago" in fish, and these allegedly "120-million-year-old" bird's rod and cone fossils stun researchers :) - 400-million-year-old Murrindalaspis placoderm fish "eye muscle attachment, the eyestalk attachment and openings for the optic nerve, and arteries and veins supplying the eyeball" The paper's author writes, "Of course, we would not expect the preservation of ancient structures made entirely of soft tissues (e.g. rods and cone cells in the retina...)." So, check this next item... :) - And... no vertebrates in the Cambrian? Well, from the journal Nature in 2014, a "Lower-Middle Cambrian... primitive fish displays unambiguous vertebrate features: a notochord, a pair of prominent camera-type eyes, paired nasal sacs, possible cranium and arcualia, W-shaped myomeres, and a post-anal tail" Primitive? - Fast-growing juvenile bone tissue, thought to appear in the Cretaceous, has been pushed back 100 million years: "This pushes the origin of fibrolamellar bone in Sauropterygia back from the Cretaceous to the early Middle Triassic..."- Trilobites "advanced" (not the predicted primitive) digestion "525 million" years ago - And there's this, a "530 million year old" fish, "50 million years before the current estimate of when fish evolved" - Mycobacterium tuberculosis 100,000 yr-old MRCA (most recent common ancestor) now 245 million- Fungus long claimed to originate 500M years ago, now found at allegedly 950 Mya (and still biological "the distant past... may have been much more 'modern' than we thought." :) - A rock contained pollen a billion years before plants evolved, according to a 2007 paper describing "remarkably preserved" fossil spores in the French Alps that had undergone high-grade metamorphism - 2.5 billion year old cyanobacteria fossils (made of organic material found in a stromatolite) appear about "200 million years before the [supposed] Great Oxidation Event". - 2.7 billion year old eukaryotes (cells with a nucleus) existed (allegedly) 1 billion years before expected - 3.5 billion year "cell division evidently identical to that of living filamentous prokaryotes." - And even older cyanobacteria! At 220 million years earlier than thought, per Nature's 3.7 billion year old dating of stromatolites! - The universe and life itself (in 2019 with the universe dated a billion, now, no, wait, two billion!, years younger than previously thought, that's not only squeezing biological but also astronomical evolution, with the overall story getting really tight) - Mantis shrimp, with its rudimentary color but advanced UV vision, is allegedly ancient. - Hadrosaur teeth, all 1400 of them, were "more complex than those of cows, horses, and other well-known modern grazers." Professor stunned by the find! (RSR predicts that, by 2030 just to put an end date on it, more fossils will be found from the geologic column that will be more "advanced" as compared to living organisms, just like this hadrosaur and like the allegedly 100M year old hagfish  fossil having more slime glands than living specimens.)  - Trace fossils "exquisitely preserved" of mobile organisms (motility) dated at 2.1 billion years ago, a full 1.5 billion earlier than previously believed - Various multicellular organisms allegedly 2.1 billion years old, show multicellularity 1.5 billion years sooner than long believed   - Pre-sauropod 26,000-pound dinosaur "shows us that even as far back as 200 million years ago, these animals had already become the largest vertebrates to ever walk the Earth." - The Evo-devo squeeze, i.e., evolutionary developmental biology, as with rsr.org/evo-devo-undermining-darwinism. - Extinct Siberian one-horned rhinos coexisted with mankind. - Whale "evolution" is being crushed in the industry-wide "big squeeze". First, geneticist claims whales evolved from hippos but paleontologists say hippos evolved tens of millions of years too late! And what's worse than that is that fossil finds continue to compress the time available for whale evolution. To not violate its own plot, the Darwinist story doesn't start animals evolving back into the sea until the cast includes land animals suitable to undertake the legendary journey. The recent excavation of whale fossils on an island of the Antarctic Peninsula further compresses the already absurdly fast 10 million years to allegedly evolve from the land back to the sea, down to as little as one million years. BioOne in 2016 reported a fossil that is "among the oldest occurrences of basilosaurids worldwide, indicating a rapid radiation and dispersal of this group since at least the early middle Eocene." By this assessment, various techniques produced various published dates. (See the evidence that falsifies the canonical whale evolution story at rsr.org/whales.) * Ancient Hierarchical Insect Society: "Thanks to some well-preserved remains, researchers now believe arthropod social structures have been around longer than anyone ever imagined. The encased specimens of ants and termites recently studied date back [allegedly] 100 million years." Also from the video about "the bubonic plague", the "disease is well known as a Middle Ages mass killer... Traces of very similar bacteria were found on [an allegedly] 20-million-year-old flea trapped in amber." And regarding "Caribbean lizards... Even though they are [allegedly] 20 million years old, the reptiles inside the golden stones were not found to differ from their contemporary counterparts in any significant way. Scientists attribute the rarity [Ha! A rarity or the rule? Check out rsr.org/stasis.] to stable ecological surroundings." * Squeezing and Rewriting Human History: Some squeezing simply makes aspects of the Darwinian story harder to maintain while other squeezing contradicts fundamental claims. So consider the following discoveries, most of which came from about a 12-month period beginning in 2017 which squeeze (and some even falsify) the Out-of-Africa model: - find two teeth and rewrite human history with allegedly 9.7 million-year-old teeth found in northern Europe (and they're like Lucy, but "three times older") - date blue eyes, when humans first sported them, to as recently as 6,000 years ago   - get mummy DNA and rewrite human history with a thousand years of ancient Egyptian mummy DNA contradicting Out-of-Africa and demonstrating Out-of-Babel - find a few footprints and rewrite human history with allegedly 5.7 million-year-old human footprints in Crete - re-date an old skull and rewrite human history with a very human skull dated at 325,000 years old and redated in the Journal of Physical Anthropology at about 260,000 years old and described in the UK's Independent, "A skull found in China [40 years ago] could re-write our entire understanding of human evolution." - date the oldest language in India, Dravidian, with 80 derivatives spoken by 214 million people, which appeared on the subcontinent only about 4,500 years ago, which means that there is no evidence for human language for nearly 99% of the time that humans were living in Asia. (Ha! See rsr.org/origin-of-language for the correct explanation.) - sequence a baby's genome and rewrite human history with a 6-week old girl buried in Alaska allegedly 11,500 years ago challenging the established history of the New World. (The family buried this baby girl just beneath their home like the practice in ancient Mesopotamia, the Hebrews who sojourned in Egypt, and in Çatalhöyük in southern Turkey, one of the world's most ancient settlements.) - or was that 130,000? years ago as the journal Nature rewrites human history with a wild date for New World site - and find a jawbone and rewrite human history with a modern looking yet allegedly 180,000-year-old jawbone from Israel which "may rewrite the early migration story of our species" by about 100,000 years, per the journal Science - re-date a primate and lose yet another "missing link" between "Lucy" and humans, as Homo naledi sheds a couple million years off its age and drops from supposedly two million years old to (still allegedly) about 250,000 years old, far too "young" to be the allegedly missing link - re-analysis of the "best candidate" for the most recent ancestor to human beings, Australopithecus sediba, turns out to be a juvenile Lucy-like ape, as Science magazine reports work presented at the American Association of Physical Anthropologists 2017 annual meeting - find skulls in Morocco and "rewrite human history" admits the journal Nature, falsifying also the "East Africa" part of the canonical story - and from the You Can't Make This Stuff Up file, NPR reports in April 2019, Ancient Bones And Teeth Found In A Philippine Cave May Rewrite Human History. :) - Meanwhile, whereas every new discovery requires the materialists to rewrite human history, no one has had to rewrite Genesis, not even once. Yet, "We're not claiming that the Bible is a science textbook. Not at all. For the textbooks have to be rewritten all the time!"  - And even this from Science: "humans mastered the art of training and controlling dogs thousands of years earlier than previously thought."- RSR's Enyart commented on the Smithsonian's 2019 article on ancient DNA possibly deconstructing old myths...  This Smithsonian article about an ancient DNA paper in Science Advances, or actually, about the misuse of such papers, was itself a misuse. The published research, Ancient DNA sheds light on the genetic origins of early Iron Age Philistines, confirmed Amos 9:7 by documenting the European origin of the biblical Philistines who came from the island of Caphtor/Crete. The mainstream media completely obscured this astounding aspect of the study but the Smithsonian actually stood the paper on its head. [See also rsr.org/archaeology.]* Also Squeezing Darwin's Theory: - Evolution happens so slowly that we can't see it, yet - it happens so fast that millions of mutations get fixed in a blink of geologic time AND: - Observing a million species annually should show us a million years of evolution, but it doesn't, yet - evolution happens so fast that the billions of "intermediary" fossils are missing AND: - Waiting for helpful random mutations to show up explains the slowness of evolution, yet - adaption to changing environments is often immediate, as with Darwin's finches Finches Adapt in 17 Years, Not 2.3 Million: Charles Darwin's finches are claimed to have taken 2,300,000 years to diversify from an initial species blown onto the Galapagos Islands. Yet individuals from a single finch species on a U.S. Bird Reservation in the Pacific were introduced to a group of small islands 300 miles away and in at most 17 years, like Darwin's finches, they had diversified their beaks, related muscles, and behavior to fill various ecological niches. So Darwin's finches could diversify in just 17 years, and after 2.3 million more years, what had they evolved into? Finches! Hear this also at rsr.org/lee-spetner and see Jean Lightner's review of the Grants' 40 Years. AND: - Fossils of modern organisms are found "earlier" and "earlier" in the geologic column, and - the "oldest" organisms are increasingly found to have anatomical, proteinaceous, prokaryotic, and eukaryotic sophistication and similarity to "modern" organisms AND: - Small populations are in danger of extinction (yet they're needed to fix mutations), whereas - large populations make it impossible for a mutation to become standard AND: - Mutations that express changes too late in an organism's development can't effect its fundamental body plan, and - mutations expressed too early in an organism's development are fatal (hence among the Enyart sayings, "Like evolving a vital organ, most major hurdles for evolutionary theory are extinction-level events.") AND: - To evolve flight, you'd get bad legs - long before you'd get good wings AND: - Most major evolutionary hurdles appear to be extinction-level events- yet somehow even *vital* organs evolve (for many species, that includes reproductive organs, skin, brain, heart, circulatory system, kidney, liver, pancreas, stomach, small intestines, large intestines, lungs -- which are only a part of the complex respiration system) AND: - Natural selection of randomly taller, swifter, etc., fish, mammals, etc. explains evolution yet - development of microscopic molecular machines, feedback mechanisms, etc., which power biology would be oblivous to what's happening in Darwin's macro environment of the entire organism AND: - Neo-Darwinism suggests genetic mutation as the engine of evolution yet - the there is not even a hypothesis for modifying the vast non-genetic information in every living cell including the sugar code, electrical code, the spatial (geometric) code, and the epigenetic code AND: - Constant appeals to "convergent" evolution (repeatedly arising vision, echolocation, warm-bloodedness, etc.) - undermine most Darwinian anatomical classification especially those based on trivialities like odd or even-toed ungulates, etc. AND: - Claims that given a single species arising by abiogenesis, then - Darwinism can explain the diversification of life, ignores the science of ecology and the (often redundant) biological services that species rely upon AND: - humans' vastly superior intelligence indicates, as bragged about for decades by Darwinists, that ape hominids should have the greatest animal intelligence, except that - many so-called "primitive" creatures and those far distant on Darwin's tee of life, exhibit extraordinary rsr.org/animal-intelligence even to processing stimuli that some groups of apes cannot AND: - Claims that the tree of life emerges from a single (or a few) common ancestors - conflict with the discoveries of multiple genetic codes and of thousands of orphan genes that have no similarity (homology) to any other known genes AND (as in the New Scientist cover story, "Darwin Was Wrong about the tree of life", etc.): - DNA sequences have contradicted anatomy-based ancestry claims - Fossil-based ancestry claims have been contradicted by RNA claims - DNA-based ancestry claims have been contradicted by anatomy claims - Protein-based ancestry claims have been contradicted by fossil claims. - And the reverse problem compared to a squeeze. Like finding the largest mall in America built to house just a kid's lemonade stand, see rsr.org/200 for the astounding lack of genetic diversity in humans, plants, and animals, so much so that it could all be accounted for in just about 200 generations! - The multiplied things that evolved multiple times - Etc. * List of Ways Darwinists Invent their Tree of Life, aka Pop Goes the Weasle – Head and Shoulders, Knees and Toes: Evolutionists change their selection of what evidence they use to show 'lineage', from DNA to fossils to genes to body plans to teeth to many specific anatomical features to proteins to behavior to developmental similarities to habitat to RNA, etc. and to a combination of such. Darwinism is an entire endeavor based on selection bias, a kind of logical fallacy. By anti-science they arbitrarily select evidence that best matches whichever evolutionary story is currently preferred." -Bob E. The methodology used to create the family tree edifice to show evolutionary relationships classifies the descent of organisms based on such attributes as odd-toed and even-toed ungulates. Really? If something as wildly sophisticated as vision allegedly evolved multiple times (a dozen or more), then for cryin' out loud, why couldn't something as relatively simple as odd or even toes repeatedly evolve? How about dinosaur's evolving eggs with hard shells? Turns out that "hard-shelled eggs evolved at least three times independently in dinosaurs" (Nature, 2020). However, whether a genus has an odd or even number of toes, and similar distinctions, form the basis for the 150-year-old Darwinist methodology. Yet its leading proponents still haven't acknowledged that their tree building is arbitrary and invalid. Darwin's tree recently fell anyway, and regardless, it has been known to be even theoretically invalid all these many decades. Consider also bipedalism? In their false paradigm, couldn't that evolve twice? How about vertebrate and non-vertebrates, for that matter, evolving multiple times? Etc., etc., etc. Darwinists determine evolutionary family-tree taxonomic relationships based on numbers of toes, when desired, or on hips (distinguishing, for example, dinosaur orders, until they didn't) or limb bones, or feathers, or genes, or fossil sequence, or neck bone, or..., or..., or... Etc. So the platypus, for example, can be described as evolving from pretty much whatever story would be in vogue at the moment...   * "Ancient" Protein as Advanced as Modern Protein: A book review in the journal Science states, "the major conclusion is reached that 'analyses made of the oldest fossils thus far studied do not suggest that their [allegedly 145-million year-old] proteins were chemically any simpler than those now being produced.'" 1972, Biochemistry of Animal Fossils, p. 125 * "Ancient" Lampreys Just Modern Lampreys with Decomposed Brain and Mouth Parts: Ha! Researches spent half-a-year documenting how fish decay. RSR is so glad they did! One of the lessons learned? "[C]ertain parts of the brain and the mouth that distinguish the animals from earlier relatives begin a rapid decay within 24 hours..." :) * 140-million Year Old Spider Web: The BBC and National Geographic report on a 140-million year old spider web in amber which, as young-earth creationists expect, shows threads that resemble silk spun by modern spiders. Evolutionary scientists on the otherhand express surprise "that spider webs have stayed the same for 140 million years." And see the BBC. * Highly-Credentialed Though Non-Paleontologist on Flowers: Dr. Harry Levin who spent the last 15 years of a brilliant career researching paleontology presents much evidence that flowering plants had to originate not 150 million years ago but more than 300 million years ago. (To convert that to an actual historical timeframe, the evidence indicates flowers must have existed prior to the time that the strata, which is popularly dated to 300 mya, actually formed.) * Rampant Convergence: Ubiquitous appeals to "convergent" evolution (vision, echolocation, warm-bloodedness, icthyosaur/dolphin anatomy, etc.), all allegedly evolving multiple times, undermines anatomical classification based on trivialities like odd or even-toed ungulates, etc. * Astronomy's Big Evolution Squeeze: - Universe a billion, wait, two billion, years younger than thought   (so now it has to evolve even more impossibly rapidly) - Sun's evolution squeezes biological evolution - Galaxies evolving too quickly - Dust evolving too quickly - Black holes evolving too quickly - Clusters of galaxies evolving too quickly. * The Sun's Evolution Squeezes Life's Evolution: The earlier evolutionists claim that life began on Earth, the more trouble they have with astrophysicists. Why? They claim that a few billion years ago the Sun would have been far more unstable and cooler. The journal Nature reports that the Faint young Sun paradox remains for the "Sun was fainter when the Earth was young, but the climate was generally at least as warm as today". Further, our star would shoot out radioactive waves many of which being violent enough to blow out Earth's atmosphere into space, leaving Earth dead and dry like Mars without an atmosphere. And ignoring the fact that powerful computer simulators cannot validate the nebula theory of star formation, if the Sun had formed from a condensing gas cloud, a billion years later it still would have been emitting far less energy, even 30% less, than it does today. Forget about the claimed one-degree increase in the planet's temperature from man-made global warming, back when Darwinists imagine life arose, by this just-so story of life spontaneously generating in a warm pond somewhere (which itself is impossible), the Earth would have been an ice ball, with an average temperature of four degrees Fahrenheit below freezing! See also CMI's video download The Young Sun. * Zircons Freeze in Molten Eon Squeezing Earth's Evolution? Zircons "dated" 4 to 4.4 billion years old would have had to freeze (form) when the Earth allegedly was in its Hadean (Hades) Eon and still molten. Geophysicist Frank Stacey (Cambridge fellow, etc.) has suggested they may have formed above ocean trenches where it would be coolest. One problem is that even further squeezes the theory of plate tectonics requiring it to operate two billion years before otherwise claimed. A second problem (for these zircons and the plate tectonics theory itself) is that ancient trenches (now filled with sediments; others raised up above sea level; etc.) have never been found. A third problem is that these zircons contain low isotope ratios of carbon-13 to carbon-12 which evolutionists may try to explain as evidence for life existing even a half-billion years before they otherwise claim. For more about this (and to understand how these zircons actually did form) just click and then search (ctrl-f) for: zircon character. * Evolution Squeezes Life to Evolve with Super Radioactivity: Radioactivity today breaks chromosomes and produces neutral, harmful, and fatal birth defects. Dr. Walt Brown reports that, "A 160-pound person experiences 2,500 carbon-14 disintegrations each second", with about 10 disintergrations per second in our DNA. Worse for evolutionists is that, "Potassium-40 is the most abundant radioactive substance in... every living thing." Yet the percentage of Potassium that was radioactive in the past would have been far in excess of its percent today. (All this is somewhat akin to screws in complex machines changing into nails.) So life would have had to arise from inanimate matter (an impossibility of course) when it would have been far more radioactive than today. * Evolution of Uranium Squeezed by Contrasting Constraints: Uranium's two most abundant isotopes have a highly predictable ratio with 235U/238U equaling 0.007257 with a standard deviation of only 0.000017. Big bang advocates claim that these isotopes formed in distant stellar cataclysms. Yet that these isotopes somehow collected in innumerable small ore bodies in a fixed ratio is absurd. The impossibility of the "big bang" explanation of the uniformity of the uranium ratio (rsr.org/bb#ratio) simultaneously contrasts in the most shocking way with its opposite impossibility of the missing uniform distribution of radioactivity (see rsr.org/bb#distribution) with 90% of Earth's radioactivity in the Earth's crust, actually, the continental crust, and even at that, preferentially near granite! A stellar-cataclysmic explanation within the big bang paradigm for the origin of uranium is severely squeezed into being falsified by these contrasting constraints. * Remarkable Sponges? Yes, But For What Reason? Study co-author Dr. Kenneth S. Kosik, the Harriman Professor of Neuroscience at UC Santa Barbara said, "Remarkably, the sponge genome now reveals that, along the way toward the emergence of animals, genes for an entire network of many specialized cells evolved and laid the basis for the core gene logic of organisms that no longer functioned as single cells." And then there's this: these simplest of creatures have manufacturing capabilities that far exceed our own, as Degnan says, "Sponges produce an amazing array of chemicals of direct interest to the pharmaceutical industry. They also biofabricate silica fibers directly from seawater in an environmentally benign manner, which is of great interest in communications [i.e., fiber optics]. With the genome in hand, we can decipher the methods used by these simple animals to produce materials that far exceed our current engineering and chemistry capabilities." Kangaroo Flashback: From our RSR Darwin's Other Shoe program: The director of Australia's Kangaroo Genomics Centre, Jenny Graves, that "There [are] great chunks of the human genome… sitting right there in the kangaroo genome." And the 20,000 genes in the kangaroo (roughly the same number as in humans) are "largely the same" as in people, and Graves adds, "a lot of them are in the same order!" CMI's Creation editors add that "unlike chimps, kangaroos are not supposed to be our 'close relatives.'" And "Organisms as diverse as leeches and lawyers are 'built' using the same developmental genes." So Darwinists were wrong to use that kind of genetic similarity as evidence of a developmental pathway from apes to humans. Hibernating Turtles: Question to the evolutionist: What happened to the first turtles that fell asleep hibernating underwater? SHOW UPDATE Of Mice and Men: Whereas evolutionists used a very superficial claim of chimpanzee and human genetic similarity as evidence of a close relationship, mice and men are pretty close also. From the Human Genome Project, How closely related are mice and humans?, "Mice and humans (indeed, most or all mammals including dogs, cats, rabbits, monkeys, and apes) have roughly the same number of nucleotides in their genomes -- about 3 billion base pairs. This comparable DNA content implies that all mammals [RSR: like roundworms :)] contain more or less the same number of genes, and indeed our work and the work of many others have provided evidence to confirm that notion. I know of only a few cases in which no mouse counterpart can be found for a particular human gene, and for the most part we see essentially a one-to-one correspondence between genes in the two species." * Related RSR Reports: See our reports on the fascinating DNA sequencing results from roundworms and the chimpanzee's Y chromosome! * Genetic Bottleneck, etc: Here's an excerpt from rsr.org/why-was-canaan-cursed... A prediction about the worldwide distribution of human genetic sequencing (see below) is an outgrowth of the Bible study at that same link (aka rsr.org/canaan), in that scientists will discover a genetic pattern resulting from not three but four sons of Noah's wife. Relevant information comes also from mitochondrial DNA (mtDNA) which is not part of any of our 46 chromosomes but resides outside of the nucleus. Consider first some genetic information about Jews and Arabs, Jewish priests, Eve, and Noah. Jews and Arabs Biblical Ancestry: Dr. Jonathan Sarfati quotes the director of the Human Genetics Program at New York University School of Medicine, Dr. Harry Ostrer, who in 2000 said: Jews and Arabs are all really children of Abraham … And all have preserved their Middle Eastern genetic roots over 4,000 years. This familiar pattern, of the latest science corroborating biblical history, continues in Dr. Sarfati's article, Genesis correctly predicts Y-Chromosome pattern: Jews and Arabs shown to be descendants of one man. Jewish Priests Share Genetic Marker: The journal Nature in its scientific correspondence published, Y Chromosomes of Jewish Priests, by scie

america god jesus christ university california head canada black world lord australia europe israel earth uk china science bible men future space land living new york times professor nature africa european arizona green evolution search dna mind mit medicine universe study mars san diego jewish table bbc harvard nasa turkey cnn journal natural sun human color jews theory prof tree alaska hebrews fruit oxford caribbean independent plant millions mass worse npr scientists abortion genius trees cambridge pacific complex flowers egyptian ancient conservatives shocking grandma surprising dust dinosaurs hebrew whales neuroscience mat butterflies relevant new world turtles claims sanders resource constant rapid needless national geographic new york university protein evolve morocco queensland babel financial times wing legs graves hades grandpa absence infants west africa levy 100m skull ham big bang american association squeeze middle eastern grants knees astronomy smithsonian mice toes uv levine std shoulders observing middle ages homo tb east africa calif fahrenheit galileo philistines biochemistry mutation evo charles darwin rna evolutionary erwin book of mormon american indian fossil lds univ arabs neanderthals jellyfish american journal crete mesopotamia 3b proceedings insect traces fungus 500m afp clarification levites beetle genome great barrier reef pritchard sponge faint piranhas molecular biology cohn uranium mantis uc santa barbara acs fossils galaxies syrians correspondence primitive shem show updates university college parrots darwinism darwinian natural history museum squeezing analyses brun camouflage clusters new scientist potassium kagan fixation galapagos islands kohn expires levinson hand washing smithsonian magazine of mice cowen ubiquitous french alps eon oregon health kogan science university aristotelian human genome project quotations pop goes cretaceous sponges calibrating cambrian cmi astrobiology pnas harkins brian thomas soft tissue journalcode human genome spores semites science advances science daily phys biomedical research radioactivity harkin researches current biology finches ignaz semmelweis cng blubber mammalian redirectedfrom evolutionists mycobacterium rsr ancient dna australopithecus icr semmelweis see dr myr cambrian explosion make this stuff up stephen jay gould analytical chemistry cephalopod darwinists trilobites bobe sciencealert dravidian royal society b antarctic peninsula y chromosome degnan nature genetics mtdna nature ecology whitehead institute peking man arthropod intelligent designer technical institute these jews haemoglobin eocene eukaryotes hadean physical anthropology haifa israel mitochondrial eve neo darwinism enyart jonathan park walt brown japeth early cretaceous hadrosaur palaeozoic ann gibbons dna mtdna jenny graves maynard-smith physical anthropologists real science radio human genetics program kenneth s kosik kgov
British Ecological Society Journals
Patrick Finnerty: Plant odour enables patch choice by mammalian herbivores from afar

British Ecological Society Journals

Play Episode Listen Later Oct 24, 2024 23:43


Amelia Macho chats to Functional Ecology author Patrick Finnerty about his recently published research article "Odour information enables patch choice by mammalian herbivores from afar, leading to predictable plant associational effects". The team demonstrated that elephants can make patch choice decisions from afar using plant odour cues alone, and that these decisions lead to predictable associational effects on the susceptibility of high-quality focal plants to be being eaten. They also used a new method to reduce an entire complex odour profile of a low-quality plant species and reproduce this odour information artificially. This simplified odour set was as effective as real low-quality neighbours in shaping elephant patch choice and subsequently providing associational refuge to the focal plant. This research could offer a new tool to influence herbivore foraging decisions, with implications for wildlife management and conservation, including plant protection. Read the full research article here: https://doi.org/10.1111/1365-2435.14665 Check out our YouTube channel for a video of an elephant walking through the giant Y-maze Patt and his team built: https://youtu.be/OBY_xsbU-0k

Aging-US
Longevity & Aging Series (S2, E3): Dr. Jon Berner

Aging-US

Play Episode Listen Later Oct 23, 2024 37:12


In this installment of the Longevity & Aging Series, Dr. Jon Berner from the Woodinville Psychiatric Associates in Woodinville, WA, joined host Dr. Evgeniy Galimov to discuss a research paper he co-authored that was published in Volume 16, Issue 14 of Aging (Aging-US), entitled, “mTORC1 activation in presumed classical monocytes: observed correlation with human size variation and neuropsychiatric disease.” DOI - https://doi.org/10.18632/aging.206033 Corresponding author - Jon Berner - jonbernermd@gmail.com Video interview - https://www.youtube.com/watch?v=45L89MaJ7qA Abstract Background: Gain of function disturbances in nutrient sensing are likely the largest component in human age-related disease. Mammalian target of rapamycin complex 1 (mTORC1) activity affects health span and longevity. The drugs ketamine and rapamycin are effective against chronic pain and depression, and both affect mTORC1 activity. Our objective was to measure phosphorylated p70S6K, a marker for mTORC1 activity, in individuals with psychiatric disease to determine whether phosphorylated p70S6K could predict medication response. Methods: Twenty-seven females provided blood samples in which p70S6K and phosphorylated p70S6K were analyzed. Chart review gathered biometric measurements, clinical phenotypes, and medication response. Questionnaires assessed anxiety, depression, autism traits, and mitochondrial dysfunction, to determine neuropsychiatric disease profiles. Univariate and multivariate statistical analyses were used to identify predictors of medication response. Results: mTORC1 activity correlated highly with both classical biometrics (height, macrocephaly, pupil distance) and specific neuropsychiatric disease profiles (anxiety and autism). Across all cases, phosphorylated p70S6K was the best predictor for ketamine response, and also the best predictor for rapamycin response in a single instance. Conclusions: The data illustrate the importance of mTORC1 activity in both observable body structure and medication response. This report suggests that a simple assay may allow cost-effective prediction of medication response. Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206033 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, ketamine, lithium, monocyte, mTORC1, rapamycin About Aging-US The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population. The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.) Please visit our website at https://www.Aging-US.com​​ and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Epigenetics Podcast
Epigenetic Mechanisms of Mammalian Germ Cell Development (Mitinori Saitou)

Epigenetics Podcast

Play Episode Listen Later Oct 17, 2024 39:49


In this episode of the Epigenetics Podcast, we talked with Mitinori Saitou from Kyoto University about his work on germ cell development, focusing on proteins like BLIMP1 and PRDM14, reprogramming iPSCs, and his vision to address infertility and genetic disorders through epigenetic insights. To start our discussion, Dr. Saitou shares the foundation of his research, which centers on the mechanisms of germ cell development across various species, including mice, non-human primates, and humans. He provides insight into his early work examining the roles of two key proteins: BLIMP1 and PRDM14. These proteins are essential for germline specification in mammals, and their functions are unveiled through detailed exploration of knockout models. In particular, Dr. Saitou elucidates the critical events in germ cell specification, highlighting how disruptions to the functions of these proteins lead to significant impairments in development. As the conversation deepens, we discuss Dr. Saitou's groundbreaking advances in human-induced pluripotent stem cells (iPSCs). He elaborates on the processes involved in reprogramming these cells to form primordial germ cell-like cells, emphasizing the significance of understanding various cellular contexts and transcriptional regulation. Dr. Saitou then details how overexpression of certain factors in embryonic stem cells can induce these germline characteristics, presenting the promise of innovation in regenerative medicine and reproductive biology. We end our talk with the exploration of chromatin remodeling that occurs during germ cell development, including fascinating details about DNA and histone modification dynamics. Dr. Saitou articulates how the epigenetic landscape shifts during the transition from pluripotent states to germ cell specification, providing a detailed comparison between mouse and human systems. This highlights the complexity of gene regulation and the importance of specific epigenetic markers in establishing and maintaining cellular identity.   References Yamaji, M., Seki, Y., Kurimoto, K. et al. Critical function of Prdm14 for the establishment of the germ cell lineage in mice. Nat Genet 40, 1016–1022 (2008). https://doi.org/10.1038/ng.186 Katsuhiko Hayashi et al., Offspring from Oocytes Derived from in Vitro Primordial Germ Cell–like Cells in Mice. Science 338, 971-975 (2012). DOI: 10.1126/science.1226889 Nakaki, F., Hayashi, K., Ohta, H. et al. Induction of mouse germ-cell fate by transcription factors in vitro. Nature 501, 222–226 (2013). https://doi.org/10.1038/nature12417 Nakamura, T., Okamoto, I., Sasaki, K. et al. A developmental coordinate of pluripotency among mice, monkeys and humans. Nature 537, 57–62 (2016). https://doi.org/10.1038/nature19096 Murase, Y., Yokogawa, R., Yabuta, Y. et al. In vitro reconstitution of epigenetic reprogramming in the human germ line. Nature 631, 170–178 (2024). https://doi.org/10.1038/s41586-024-07526-6   Contact Epigenetics Podcast on X Epigenetics Podcast on Instagram Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Epigenetics Podcast on Threads Active Motif on X Active Motif on LinkedIn Email: podcast@activemotif.com

Real Science Exchange
Understanding Choline: An Overlooked Nutrient in Pigs and Chickens with Dr. Digler from the University of Illinois

Real Science Exchange

Play Episode Listen Later Oct 1, 2024 61:33


This episode of the Real Science Exchange podcast was recorded during a webinar from Balchem's Real Science Lecture Series. Choline was discovered in 1862 in pig and ox bile (“chole” in Greek). It is a simple nutrient containing five carbons and a nitrogen. Choline is considered a quasi-vitamin since its requirements and de novo synthesis are both higher than the B vitamins it's similar to. Pigs can synthesize more choline than chickens. Choline is considered to be a conditionally essential nutrient depending on the physiological stage and choline production ability of the species being considered. (3:29)Choline is involved in cellular maintenance and growth at all life stages. In particular, it's involved in neurotransmission as a component of both sphingomyelin and acetylcholine. Phosphatidylcholine is a major component of cellular and organelle membranes and is involved in lipoprotein synthesis for the transport of lipids. Choline is converted to betaine upon oxidation, and betaine plays an important role in one-carbon metabolism as a methyl group donor. (8:43)Dietary-free choline is preferentially used for acetylcholine and phosphatidylcholine synthesis. Phosphatidylcholine is the most abundant form of choline in the body. In general, water-soluble forms of choline are absorbed faster and have a higher tissue incorporation rate than lipid-soluble forms. (14:58) Clinical signs of choline deficiency include reduced growth and reproductive performance. In pigs and chickens, choline-deficient diets lead to lipid accumulation in the liver. In broiler chickens, perosis is a classic choline deficiency sign and may progress to slipped tendons. From human studies, we know that insufficient methylation capacity during early development increases the risk of neural tube defects and impaired cognitive function. (16:44)As animals age, their dietary source of choline transitions from water-soluble forms to lipid-soluble forms. Mammalian young receive water-soluble choline from milk, and avian species from the egg yolk. After weaning in pigs and at the hatch in chickens, the dietary choline source transitions to lipid-soluble forms found in oilseed meals. Dr. Dilger goes on to describe choline concentrations in common feedstuffs and supplements. Feedstuff type and processing methods have a profound influence on bioavailable choline content. (19:16)Dr. Dilger details some of his work with choline and betaine in poultry diets. The requirement for preformed choline is relatively high for poultry because they lack capacity in a particular methyl transferase enzyme responsible for de novo synthesis. They also have relatively high choline oxidase activity which favors the formation of betaine from choline. Betaine is critical as a buffer to counteract the toxic effects of uric acid in the avian kidney. Dr. Dilger describes choline dietary requirements for avian species. (27:38)Pigs have more efficient methyl transferase activity for de novo synthesis of choline. Sufficient choline is provided by milk and practical diets. For growing pigs consuming corn-soybean meal diets where methionine can completely spare choline, there is little benefit of choline supplementation for growth. Choline requirements increase for gestating and lactating sows. Swine requirements for choline were set in the 1940s and 1950s. Dr. Dilger believes these requirements need a second look given the great changes in pig and crop genetics since the requirements were originally established. To that end, work in his lab has shown that choline intake during gestation and lactation influences sow milk composition, body choline concentrations and forms, metabolomic profiles and brain development of pigs. (35:18)In conclusion, Dr. Dilger considers choline a pervasive nutrient due to its crucial metabolic roles. Species-specific idiosyncrasies drive choline requirements, and analytical data for choline-related compounds is lacking. Different forms of choline have different metabolic kinetics and the potential for choline deficiency remains a practical issue. (46:15)In closing, Dr. Dilger answers an extensive set of questions from the audience. Watch the full webinar at balchem.com/realscience. (48:32)Please subscribe and share with your industry friends to invite more people to join us at the Real Science Exchange virtual pub table.  If you want one of our Real Science Exchange t-shirts, screenshot your rating, review, or subscription, and email a picture to anh.marketing@balchem.com. Include your size and mailing address, and we'll mail you a shirt.

Natural Resources University
Impacts of Megafires on Wildlife Communities | Fire University #329

Natural Resources University

Play Episode Listen Later Sep 16, 2024 45:19


Dr. Kendall Calhoun of UCLA and UC Davis joins us to discuss the impact of megafires on wildlife communities. We delve into what defines a megafire, explore his research on wildlife and habitat responses to megafires, and discuss both the positive and negative effects of these events.   Resources: Calhoun, K. L., et al. (2024). Movement behavior in a dominant ungulate underlies successful adjustment to a rapidly changing landscape following megafire. Movement Ecology, 12(1), 53. Calhoun, K. L. et al. (2023). Mammalian resistance to megafire in western US woodland savannas. Ecosphere, 14(7), e4613. Calhoun, K. L. et al.  (2022). Spatial overlap of wildfire and biodiversity in California highlights gap in non‐conifer fire research and management. Diversity and Distributions, 28(3), 529-541. Kreling, S. E. et al.  (2021). Site fidelity and behavioral plasticity regulate an ungulate's response to extreme disturbance. Ecology and Evolution, 11(22), 15683-15694.   Dr. Kendall Calhoun @kenleecalhoun, @kenleecalhoun,  Academic Profile Dr. Carolina Baruzzi @wildlandmgmt, Academic Profile Dr. Marcus Lashley @DrDisturbance, Academic Profile   Have suggestions for future episodes? Send us your feedback! (here) Check out our newest podcast, Wild Turkey Science! Enroll now in our free, online fire course. Available to all. This podcast is supported by listener donations - thank you for being a part of this effort. For more information, follow UF DEER Lab on Instagram, Facebook, Twitter, YouTube.   Music by Dr. David Mason and Artlist.io Produced and edited by Charlotte Nowak  

Fire University
Impacts of Megafires on Wildlife Communities | #43

Fire University

Play Episode Listen Later Sep 16, 2024 45:07


Dr. Kendall Calhoun of UCLA and UC Davis joins us to discuss the impact of megafires on wildlife communities. We delve into what defines a megafire, explore his research on wildlife and habitat responses to megafires, and discuss both the positive and negative effects of these events.   Resources: Calhoun, K. L., et al. (2024). Movement behavior in a dominant ungulate underlies successful adjustment to a rapidly changing landscape following megafire. Movement Ecology, 12(1), 53. Calhoun, K. L. et al. (2023). Mammalian resistance to megafire in western US woodland savannas. Ecosphere, 14(7), e4613. Calhoun, K. L. et al.  (2022). Spatial overlap of wildfire and biodiversity in California highlights gap in non‐conifer fire research and management. Diversity and Distributions, 28(3), 529-541. Kreling, S. E. et al.  (2021). Site fidelity and behavioral plasticity regulate an ungulate's response to extreme disturbance. Ecology and Evolution, 11(22), 15683-15694.   Dr. Kendall Calhoun @kenleecalhoun, @kenleecalhoun,  Academic Profile Dr. Carolina Baruzzi @wildlandmgmt, Academic Profile Dr. Marcus Lashley @DrDisturbance, Academic Profile   Have suggestions for future episodes? Send us your feedback! (here) Check out our newest podcast, Wild Turkey Science! Enroll now in our free, online fire course. Available to all. This podcast is supported by listener donations - thank you for being a part of this effort. For more information, follow UF DEER Lab on Instagram, Facebook, Twitter, YouTube.   Music by Dr. David Mason and Artlist.io Produced and edited by Charlotte Nowak

Laura Erickson's For the Birds
The bear necessities and other close encounters of the mammalian kind

Laura Erickson's For the Birds

Play Episode Listen Later Aug 6, 2024 4:42


Two mammals made a visit to Laura's yard on Sunday night.

Alleine nicht Einsam
#54 Human Design für Tiere: Mammalian Design mit Ines Winkelbauer

Alleine nicht Einsam

Play Episode Listen Later Jul 7, 2024 54:41


In dieser Folge spreche ich mit einer Klientin von mir. Ines war bei mir 3 Monate lang im Krafteffecst Sichtbarkeits-Mentoring und spricht über ihren Weg und ihre Herausforderungen auf ihrem Weg ihr Herzensbusiness aufzubauen. Du erfährst in dieser Folge mehr über Ines Arbeit als Tierenergetikerin und lernst das Mammalian Design - das Human Design für Tiere kennen. Mehr über Ines: https://www.instagram.com/ines_energie_mammalian https://energie-mammalian.at --------------------------------------- Mehr über Lara von Krafteffects: Instagram: https://www.instagram.com/krafteffects.coaching Webseite: https://www.krafteffects.de E-Mail: kontakt@krafteffects.de

Inspiring Human Potential
No torture chambers in bed for peeps who live our mammalian heritage secure attachment, mystic & not

Inspiring Human Potential

Play Episode Listen Later Jul 5, 2024 14:45


IHP YouTube video podcast episode made available to our other IHP podcast platforms. IHP content is for people who are interested in topics, stories, & guidance for personal development, self-help, spirituality journey, the 5D mystic path, & enlightenment the human way. It's for those who choose the human love narrative, not the human suffering narrative. Don't tune in if you don't love life and humanity because this won't be for you. Don't tune in if you still believe in evil or the devil. Topic not ideal for ego-sensitive or emotionally sensitive (on any/all life - including socio-pol-eco - topics) people. Please do not tune in. Thank you! All IHP content resonates with people who want to achieve enlightenment the human way. IHP podcast host Maria Florio shares voices, stories and perspectives from her 5D mystic enlightenment functional adult life to give examples of what it's like to know emotional self-regulation skills, experience secure attachment, have functional adult conversations and experience 5D relationships (5D and beyond vibing people). You hear about how easy it is to be yourself, to pursue inner growth, to unconditionally love, to have compassion, and live your best life with outer and inner-well being in the forefront. Also explored, how to communicate and handle emotionally insecure adaptive children grown ups, the 3D or 4D vibing individuals, those who stay within insecure emotional human suffering vibration experience and mindset, or who hold drama as the go-to in relationships, or use projection due to unresolved and unaddressed trauma, attachment wounds, and inner child wounds that come up in their behavior. Since trauma is relational and intimacy necessary to heal it, through Maria's stories and perspectives people get an idea of securely attached options on how to handle projection to the best of your ability and create a safe environment for another person to heal or for you to set a healthy boundary if the person bringing the projection (3D/4D drama vibe) is not seeking to move beyond their safety behavior/unresolved trauma emotional response. All of what we do in our day-to-day relationships, conversations, and interactions can bring the potential for healing and expansion of consciousness. The content is for people who are or want to be self-aware, accountable & want to establish functional adult secure attachment emotionally mature behaviors & relationships in life. Your humanity is living a life of meaning & connection beyond the solo-self, as is the true spirituality life. We welcome all people of all walks of life to reclaim their inner child & live their inner child adult, to pursue integration of the brain & restorative embodied self-aware life in time & through healthy self-worth functional adult secure attachment 5D relationships. IHP podcast host Maria Florio shares voices, stories & perspectives from her 5D mystic enlightenment functional adult life to give examples of what it's like to know emotional self-regulation skills, experience secure attachment, have functional adult conversations & experiences & 5D relationships. This and more is what the IHP content and community is all about. Welcome and thanks for tuning in! Love, Maria, your 5D mystic enlightenment functional adult woo-woo pseudoscience lady IHP podcast host talking about the amazing journey of human evolution & consciousness♾️

Ruthless Compassion with Dr. Marcia Sirota
166 - The Truth About Our Mammalian Brain With Loretta Breuning, PhD

Ruthless Compassion with Dr. Marcia Sirota

Play Episode Listen Later Jun 6, 2024 36:59


Disclaimer: We were having difficulties with our audio. We apologize for the poor sound quality. Loretta Breuning, PhD, is Founder of the Inner Mammal Institute and Professor Emerita of Management at California State University, East Bay. She is the author of many personal development books, including Habits of a Happy Brain: Retrain Your Brain to Boost Your Serotonin, Dopamine, Oxytocin and Endorphin Levels. As a teacher and a parent, she was not convinced by prevailing theories of human motivation. Then she learned about the brain chemistry we share with earlier mammals and everything made sense. She began creating resources that have helped thousands of people make peace with their inner mammal. Dr. Breuning's work has been translated into sixteen languages and is cited in major media. Before teaching, she worked for the United Nations in Africa. Loretta gives zoo tours on animals behavior, after serving as a Docent at the Oakland Zoo. She is a graduate of Cornell University and Tufts. The Inner Mammal Institute offers videos, podcasts, books, blogs, multimedia, a training program, and a free five-day happy-chemical jumpstart. Details are available at InnerMammalInstitute.org. Website: https://innermammalinstitute.org Facebook: https://www.facebook.com/LorettaBreuningPhD X: https://twitter.com/InnerMammal Instagram: https://www.instagram.com/inner.mammal.inst/ Youtube: https://www.youtube.com/c/InnerMammalInstitute Linkedin: https://www.linkedin.com/in/lorettabreuning/ New book: Why You're Unhappy: Biology vs Politics https://innermammalinstitute.org/why Promo Code: 20% off my course with the code HAPPY20 https://innermammalinstitute.org/course

Science (Video)
A 60-Year Journey of Mammalian Fertilization with Ryuzo Yanagimachi 2023 Kyoto Prize Laureate in Advanced Technology

Science (Video)

Play Episode Listen Later May 6, 2024 73:21


Born and raised in Hokkaido, Japan, Professor Ryuzo Yanagimachi, the 2023 Kyoto Prize Laureate in Basic Sciences, developed a love for nature. He became fascinated with the fertilization process of sea urchins. After studying the fertilization of fish and the life cycle of parasitic barnacles, he realized little was known about mammalian fertilization. He went on to train with Professor M.C. Chang at the Worcester Foundation for Experimental Biology, the father of mammalian in vitro fertilization and then started his own lab at the University of Hawai'i. His basic studies contributed to understanding the hidden capacity of sperm and eggs and overcoming human fertility problems. Professor Yanagimachi passed away in 2023 at the age of 95, just a few months before he was to receive his Kyoto Prize award. Dr. W. Steven Ward, Director of the Institute for Biogenesis Research at the University of Hawai'i will present Prof. Yanagimachi's life and work. Series: "Kyoto Prize Symposium" [Health and Medicine] [Science] [Show ID: 39423]

Health and Medicine (Video)
A 60-Year Journey of Mammalian Fertilization with Ryuzo Yanagimachi 2023 Kyoto Prize Laureate in Advanced Technology

Health and Medicine (Video)

Play Episode Listen Later May 6, 2024 73:21


Born and raised in Hokkaido, Japan, Professor Ryuzo Yanagimachi, the 2023 Kyoto Prize Laureate in Basic Sciences, developed a love for nature. He became fascinated with the fertilization process of sea urchins. After studying the fertilization of fish and the life cycle of parasitic barnacles, he realized little was known about mammalian fertilization. He went on to train with Professor M.C. Chang at the Worcester Foundation for Experimental Biology, the father of mammalian in vitro fertilization and then started his own lab at the University of Hawai'i. His basic studies contributed to understanding the hidden capacity of sperm and eggs and overcoming human fertility problems. Professor Yanagimachi passed away in 2023 at the age of 95, just a few months before he was to receive his Kyoto Prize award. Dr. W. Steven Ward, Director of the Institute for Biogenesis Research at the University of Hawai'i will present Prof. Yanagimachi's life and work. Series: "Kyoto Prize Symposium" [Health and Medicine] [Science] [Show ID: 39423]

University of California Audio Podcasts (Audio)
A 60-Year Journey of Mammalian Fertilization with Ryuzo Yanagimachi 2023 Kyoto Prize Laureate in Advanced Technology

University of California Audio Podcasts (Audio)

Play Episode Listen Later May 6, 2024 73:21


Born and raised in Hokkaido, Japan, Professor Ryuzo Yanagimachi, the 2023 Kyoto Prize Laureate in Basic Sciences, developed a love for nature. He became fascinated with the fertilization process of sea urchins. After studying the fertilization of fish and the life cycle of parasitic barnacles, he realized little was known about mammalian fertilization. He went on to train with Professor M.C. Chang at the Worcester Foundation for Experimental Biology, the father of mammalian in vitro fertilization and then started his own lab at the University of Hawai'i. His basic studies contributed to understanding the hidden capacity of sperm and eggs and overcoming human fertility problems. Professor Yanagimachi passed away in 2023 at the age of 95, just a few months before he was to receive his Kyoto Prize award. Dr. W. Steven Ward, Director of the Institute for Biogenesis Research at the University of Hawai'i will present Prof. Yanagimachi's life and work. Series: "Kyoto Prize Symposium" [Health and Medicine] [Science] [Show ID: 39423]

Health and Medicine (Audio)
A 60-Year Journey of Mammalian Fertilization with Ryuzo Yanagimachi 2023 Kyoto Prize Laureate in Advanced Technology

Health and Medicine (Audio)

Play Episode Listen Later May 6, 2024 73:21


Born and raised in Hokkaido, Japan, Professor Ryuzo Yanagimachi, the 2023 Kyoto Prize Laureate in Basic Sciences, developed a love for nature. He became fascinated with the fertilization process of sea urchins. After studying the fertilization of fish and the life cycle of parasitic barnacles, he realized little was known about mammalian fertilization. He went on to train with Professor M.C. Chang at the Worcester Foundation for Experimental Biology, the father of mammalian in vitro fertilization and then started his own lab at the University of Hawai'i. His basic studies contributed to understanding the hidden capacity of sperm and eggs and overcoming human fertility problems. Professor Yanagimachi passed away in 2023 at the age of 95, just a few months before he was to receive his Kyoto Prize award. Dr. W. Steven Ward, Director of the Institute for Biogenesis Research at the University of Hawai'i will present Prof. Yanagimachi's life and work. Series: "Kyoto Prize Symposium" [Health and Medicine] [Science] [Show ID: 39423]

Science (Audio)
A 60-Year Journey of Mammalian Fertilization with Ryuzo Yanagimachi 2023 Kyoto Prize Laureate in Advanced Technology

Science (Audio)

Play Episode Listen Later May 6, 2024 73:21


Born and raised in Hokkaido, Japan, Professor Ryuzo Yanagimachi, the 2023 Kyoto Prize Laureate in Basic Sciences, developed a love for nature. He became fascinated with the fertilization process of sea urchins. After studying the fertilization of fish and the life cycle of parasitic barnacles, he realized little was known about mammalian fertilization. He went on to train with Professor M.C. Chang at the Worcester Foundation for Experimental Biology, the father of mammalian in vitro fertilization and then started his own lab at the University of Hawai'i. His basic studies contributed to understanding the hidden capacity of sperm and eggs and overcoming human fertility problems. Professor Yanagimachi passed away in 2023 at the age of 95, just a few months before he was to receive his Kyoto Prize award. Dr. W. Steven Ward, Director of the Institute for Biogenesis Research at the University of Hawai'i will present Prof. Yanagimachi's life and work. Series: "Kyoto Prize Symposium" [Health and Medicine] [Science] [Show ID: 39423]

UC San Diego (Audio)
A 60-Year Journey of Mammalian Fertilization with Ryuzo Yanagimachi 2023 Kyoto Prize Laureate in Advanced Technology

UC San Diego (Audio)

Play Episode Listen Later May 6, 2024 73:21


Born and raised in Hokkaido, Japan, Professor Ryuzo Yanagimachi, the 2023 Kyoto Prize Laureate in Basic Sciences, developed a love for nature. He became fascinated with the fertilization process of sea urchins. After studying the fertilization of fish and the life cycle of parasitic barnacles, he realized little was known about mammalian fertilization. He went on to train with Professor M.C. Chang at the Worcester Foundation for Experimental Biology, the father of mammalian in vitro fertilization and then started his own lab at the University of Hawai'i. His basic studies contributed to understanding the hidden capacity of sperm and eggs and overcoming human fertility problems. Professor Yanagimachi passed away in 2023 at the age of 95, just a few months before he was to receive his Kyoto Prize award. Dr. W. Steven Ward, Director of the Institute for Biogenesis Research at the University of Hawai'i will present Prof. Yanagimachi's life and work. Series: "Kyoto Prize Symposium" [Health and Medicine] [Science] [Show ID: 39423]

The Birthful Podcast | Talking with Pregnancy, Birth, Breastfeeding, Postpartum & Parenting Pros to Inform Your Intuition
Helping Your Mammalian Body (and Baby!) Have an Easier and More Connected Birth

The Birthful Podcast | Talking with Pregnancy, Birth, Breastfeeding, Postpartum & Parenting Pros to Inform Your Intuition

Play Episode Listen Later Apr 17, 2024 50:36


During labor, you want contractions that are longer, stronger, and closer together. But why? Dr. Sarah Buckley and Adriana take a deep dive into the amazing and fascinating hormonal dance that happens during the birthing process, and how interventions such as synthetic oxytocin or an epidural can lead to a cascade of interventions that negatively impact the process for both the birthing person and their baby. They also talk about ways to support the physiology of birth (regardless of what path it takes) in order to help fill any ‘hormonal gaps' that may occur.Sponsor offers - TIME SENSITIVE! NEEDED - Get 20% off at ThisIsNeeded.com with code BIRTHFULHONEYLOVE - Get 20% off at HoneyLove.com/Birthful JENNI KAYNE - Get 15% off at JenniKayne.com/Birthful with code BIRTHFUL15ONESKIN - Get 15% off at https://www.OneSkin.co/ with code BIRTHFULFAMILYALBUM APP - Download the app for free, wherever you get your apps! MY LIFE IN A BOOK - Get 10% off at MyLifeInABook.com with code BIRTHFULAQUATRU - Get 20% off at AquaTru.com with code BIRTHFULGet the most out of this episode by checking out the resources, transcript, and links listed on its show notes page.  If you liked this episode, listen to our interview on Your Baby, The Mammal and our episode on How to Avoid a "Cascade of Interventions".You can connect with Sarah on Facebook at drsarahbuckley. You can connect with us on Instagram at @BirthfulPodcast and email us at podcast@Birthful.com. If you enjoy what you hear, download Birthful's Postpartum Plan FREE when you sign up for our weekly newsletter! You can also sign up for Adriana's Own Your Birth online BIRTH preparation classes and her Thrive with Your Newborn online POSTPARTUM preparation course at BirthfulCourses.com.Follow us on Goodpods, Apple Podcasts, Amazon Music, Spotify, and anywhere you listen to podcasts.Our Sponsors:* Check out mylifeinabook.com and use code BIRTHFUL at checkout for 10% off. Create an unforgettable gift for your mom this Mother's Day.* Visit HomeThreads.com/BIRTHFUL today and get a 15% off code for your first order!Support this podcast at — https://redcircle.com/birthful/donationsAdvertising Inquiries: https://redcircle.com/brands

Ologies with Alie Ward
Smologies #40: HAIR with Valerie Horsley

Ologies with Alie Ward

Play Episode Listen Later Mar 18, 2024 25:10


Peach fuzz. Chin hairs. Mammalian ponytails. WHY DO THEY HAPPEN. Yale researcher and associate professor Dr. Valerie Horsley stops by California to chat with Alie about the nature of hair and what it has to do with skin and nails, stem cells, how it grows, why some of us have curly hair or straight hair or thin hair or thick hair, and why we love and hate and need our hair as animals.Dr. Valerie Horsely is on FacebookThe Horsely Lab at YaleMore episode sources & linksFull-length (*not* G-rated) Trichology episode + tons of science linksMore kid-friendly Smologies episodes!Become a patron of Ologies for as little as a buck a monthOlogiesMerch.com has hats, shirts, hoodies, totes!Follow @Ologies on X and InstagramFollow @AlieWard on X and InstagramSound editing by Mercedes Maitland of Maitland Audio Productions and Steven Ray MorrisMade possible by work from Noel Dilworth, Susan Hale, Kelly R. Dwyer & Erin TalbertSmologies theme song by Harold Malcolm

Mind & Matter
Endogenous DMT in the Mammalian Brain | Nicolas Glynos | #142

Mind & Matter

Play Episode Listen Later Feb 29, 2024 96:44


Dr. Nicolas Glynos received his PhD in Molecular & Integrative Physiology from the University of Michigan, where he studied the psychedelic drug DMT in the mammalian brain. They discuss: the history of DMT research; the use of DMT in ayahuasca; whether DMT is found endogenously in animals; why plants produce DMT; pineal gland, DMT & melatonin; the latest research looking at the presence and effects of DMT in the brain; and more.More M&M content about psychedelics: https://substack.com/search/psychedelics?focusedPublicationId=513528&searching=focused_posts#psychedelics #DMT #science #neuroscience #podcast #serotoninSupport the showFind all podcast & written content at the M&M Substack:[https://mindandmatter.substack.com]Learn how to further support the podcast: [https://mindandmatter.substack.com/p/how-to-support-mind-and-matter]Try Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase.Try SiPhox Health—Affordable, at-home bloodwork w/ a comprehensive set of key health marker. Use code TRIKOMES for a 10% discount.Try the Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for $50 off...

Further Together the ORAU Podcast
Training future workers in bioprocessing: ORAU's Innovation Partnership with Villanova University

Further Together the ORAU Podcast

Play Episode Listen Later Jan 18, 2024 37:16


ORAU and Villanova University teamed up to offer a workshop during which participants received certification in Basic Industry Bioprocessing Techniques. In this episode of Further Together, host Michael Holtz talks with Rosalind Wynn, associate professor in the Villanova Department of Electrical and Computer Engineering, and Tracie Curtright, ORAU project manager, about the Innovation Partnership Program that funded the workshop. The certification earned by workshop participants is recognized by most pharmaceutical industry processing facilities. Participants were successful in growing cells and were able to measure cell viability/population. Mammalian cell culture samples created during this workshop are currently under cryopreservation storage for use in future collaborative projects between Villanova and Jefferson Institute for Bioprocessing. To learn more about the Innovation Partnership Program, visit https://orau.org/partnerships/grant-programs/innovation-partnerships.html

Authentic Biochemistry
BioMedical Portrait VIII.c.7. Differential control over fatty acid oxygenation and PPAR/RXR heterodimer pairing in mammalian uterine cell estrus physiology.DJGPhD.8Jan2024

Authentic Biochemistry

Play Episode Listen Later Jan 9, 2024 30:00


References General and Comparative Endocrinology,2018-06-01, Volume 262, Pages 27-35 Pisendel JG 1735.Violin Concerto in D major, JunP I.5. https://youtu.be/dvwhXXvFiNg?si=YfS2waKLC5WHy0En --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support

Authentic Biochemistry
BioMedical Portrait VIII.c.6 Precursor 20:4 5,8,11,14 derived prostaglandins and leukotriene roles in PPAR and RXR transcription factor expression in mammalian reproductive tissues. DJGPhD. 04JAN24.AB

Authentic Biochemistry

Play Episode Listen Later Jan 4, 2024 30:00


References General and Comparative Endocrinology 2018-06-01, Volume 262, Pages 27-35. Immunohorizons. 2022 Jun 22; 6(6): 366–372. Biochem J. 2009 Dec 14;425(1):265-74. Nature. 2023; 614(7948): 530–538. Winwood,S. 1969 Blind Faith "Had to Cry Today". https://youtu.be/Z4Yo_VbGdMg?si=3whbMcoWNFtfgPwE --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support

BioInnovation Spotlight
Jack Reid and Adam Glen, co-founders of Unicorn Biotechnologies

BioInnovation Spotlight

Play Episode Listen Later Dec 7, 2023 19:14


Mammalian cell culture is difficult to scale up. Many cell types do not grow well in suspension and preferably attach to surfaces like the bottom of their flasks. Currently, researchers examine this growth manually and culture cells by hand in specialized cell culture flasks.Cell culture is critical in many fields of research, from healthcare to future food technology, and scaling this technique using automated processes is the holy grail of manufacturing cell-based products that are both affordable and high-quality.Unicorn Biotechnologies was founded by Adam Glen and Jack Reid to take on this challenge. In this episode of BioInnovator Spotlight, Adam and Jack tell us what motivated them to enter the world of automation, how they met at Entrepreneur First, and what they hope to achieve with Unicorn in the coming year.

The Mind of Flex
The reduction of all existence to Is reptilian and mammalian instincts

The Mind of Flex

Play Episode Listen Later Dec 4, 2023 10:10


I get that humans are no different than any mammal who are slaves to their base instincts but modernity is ridiculous --- Support this podcast: https://podcasters.spotify.com/pod/show/flex-johnson/support

Mind Pump: Raw Fitness Truth
2208: The Truth About the Leg Press, the Pros & Cons of Cold Plunging After a Workout, Mind Pump's London Diet & Training Break Down & More

Mind Pump: Raw Fitness Truth

Play Episode Listen Later Nov 17, 2023 89:11


In this episode of Quah (Q & A), Sal, Adam & Justin answer four Pump Head questions drawn from last Sunday's Quah post on the @mindpumpmedia Instagram page.  Mind Pump Fit Tip: The next time you hear a diet/fitness influencer say reverse dieting doesn't work, turn them off, they are morons. (2:00) Highlighting how much we strive for the recognition of our peers. (12:20) The power of genetics. (23:38) The ultimate performance stack from Organifi. (32:25) Loving your kid more than yourself. (33:34) Love is an action. (39:20) Sal's new TRT strategy. (47:14) Butcher Box's CRAZY Black Friday deal. (52:55) Is the human extinction movement a real thing? (56:39) Shout out to Edgar Goulas. (58:39) #Quah question #1 - What do the different foot and leg positions work on a leg press machine? (1:00:48) #Quah question #2 - Is it possible to increase BMR beyond what traditional calculators say simply with reverse dieting and strength training? (1:07:04) #Quah question #3 - Is cold plunging post-workout worth the tradeoff of blunting the muscle-building signal if it leads to better recovery, and therefore, more frequency and volume? (1:09:50) #Quah question #4 - Did you all train while in London? What did your nutrition look like? What new foods did you guys try? (1:16:01) Related Links/Products Mentioned Visit Organifi for the exclusive offer for Mind Pump listeners! **Promo code MINDPUMP at checkout** Visit Butcher Box for this month's exclusive Mind Pump offer! November Promotion: MAPS Resistance | MAPS Prime Pro 50% off! **Code NOVEMBER50 at checkout** Mammalian metabolism photo Mind Pump #1915: How To Re-Ignite Your Metabolism Planet Fitness Unexpectedly Fires its CEO, and Shares Plunge Doppelgängers Don't Just Look Alike—They Also Share DNA Three Identical Strangers The Weird Mental Frameworks Of The Super Rich - Codie Sanchez | Modern Wisdom 695 TRANSCEND your goals! Telehealth Provider • Physician Directed GET YOUR PERSONALIZED TREATMENT PLAN!  Hormone Replacement Therapy, Cognitive Function, Sleep & Fatigue, Athletic Performance and MORE. Their online process and medical experts make it simple to find out what's right for you. Earth Now Has 8 Billion Humans. This Man Wishes There Were None. Jonathan Pageau encourages World Leaders to pursue the supreme Good Visit Hiya for an exclusive offer for Mind Pump listeners! How to do a Bulgarian Split Squat - YouTube Front Squats- How to Place & Hold the Bar - YouTube THIS Is The BEST Side Butt Exercise! - YouTube MAPS Macro Calculator Visit The Cold Plunge for an exclusive offer for Mind Pump Listeners! **Promo code MINDPUMP at checkout for $150 off your order** Mind Pump #1822: Wim Hof On How To Control Your Immune System With Breathwork Mind Pump Podcast – YouTube Mind Pump Free Resources People Mentioned Elon Musk (@elonmusk) X Drew Canole (@drewcanole) Instagram Chris Williamson (@chriswillx) Instagram Codie Sanchez (@codiesanchez) Instagram Dr. Dwayne N. Jackson, PhD (@drdnjackson) Instagram Jonathan Pageau (@jonathan.pageau) Instagram Edgar Goulas (@eddy_teddy21) Instagram Justin Brink DC (@dr.justinbrink) Instagram Wim Hof (@iceman_hof) Instagram

Grand Slam Journey
56. Loretta Breuning: The Evolutionary Science of our Mammalian Brain - Decoding Emotions and Behavior

Grand Slam Journey

Play Episode Listen Later Nov 7, 2023 70:23 Transcription Available


What if you were given the key to understanding your own emotions and behavior? Prepare to venture on a fascinating exploration of the human brain with our esteemed guest Loretta Breuning Ph.D, the founder of the Inner Mammal Institute, an author of 8 books, and a  host of The Happy Brain podcast. We delve into the power of brain chemicals - serotonin, dopamine, oxytocin, and endorphins and the impact of childhood experiences on our neural development, and strategies for managing our emotions. We're not stopping there. We're also diving deep into the role of cortisol - the stress hormone often overlooked in discussions about emotions. We examine our responses to fear and survival, and how these are linked to our evolution. Moreover, we provide practical tips on how to relieve cortisol and shed light on how our brain's operating system functions. In the latter stages, we navigate the complex terrain of negative thoughts, pursuits, and disappointments, expectation setting, unraveling how these scenarios impact our neural pathways. We also discuss the differences in behavior between men and women from an evolutionary perspective, and how our expectations are directly linked to our dopamine levels. Join us as we reveal the power of creating new neural pathways, even in the face of fatigue or hardship. This episode is an essential listen for anyone wanting to decode the intricate science behind our emotions and behavior.Resources: Habits of a Happy Brain: Retrain Your Brain to Boost Your Serotonin, Dopamine, Oxytocin, and Endorphin LevelsThe Happy Brain PodcastInner Mammal InstituteReading ListAnger Management: I Feel PrettyNOBLE COLD PLUNGE Noble Cold Plunge creates health benefits through a hormetic stress response. Save $250 with GSJ2508 EIGHT SLEEP Save $250 on 8Sleep and get better quality and deeper sleep with automatic temperature adjustmentTESLA Use my referral link for Tesla and get up to $250 off and 3-months of Full Self-Driving CapabilityDisclaimer: This post contains affiliate links. If you make a purchase, I may receive a commission at no extra cost to you.Thank you for listening. If you enjoyed this episode, share it with someone who may enjoy it as well, and consider leaving a review on Apple Podcasts & Spotify. You can also submit your feedback directly on my website. Follow @GrandSlamJourney on Instagram, Facebook, Twitter or join the community on LinkedIn. This content is also available on Substack and YouTube.

Science (Video)
Induction of Germ Cell Fate from Mammalian Pluripotent Stem Cells with Toshihiro Kobayashi - Breaking News in Stem Cells

Science (Video)

Play Episode Listen Later Oct 1, 2023 57:27


Toshihiro Kobayashi, Ph.D., presents his research on the mechanisms driving cell fate choices in early mammalian embryos. He also discusses the potential application of these principles in future regenerative medicine. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38328]

Health and Medicine (Video)
Induction of Germ Cell Fate from Mammalian Pluripotent Stem Cells with Toshihiro Kobayashi - Breaking News in Stem Cells

Health and Medicine (Video)

Play Episode Listen Later Oct 1, 2023 57:27


Toshihiro Kobayashi, Ph.D., presents his research on the mechanisms driving cell fate choices in early mammalian embryos. He also discusses the potential application of these principles in future regenerative medicine. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38328]

University of California Audio Podcasts (Audio)
Induction of Germ Cell Fate from Mammalian Pluripotent Stem Cells with Toshihiro Kobayashi - Breaking News in Stem Cells

University of California Audio Podcasts (Audio)

Play Episode Listen Later Oct 1, 2023 57:27


Toshihiro Kobayashi, Ph.D., presents his research on the mechanisms driving cell fate choices in early mammalian embryos. He also discusses the potential application of these principles in future regenerative medicine. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38328]

Health and Medicine (Audio)
Induction of Germ Cell Fate from Mammalian Pluripotent Stem Cells with Toshihiro Kobayashi - Breaking News in Stem Cells

Health and Medicine (Audio)

Play Episode Listen Later Oct 1, 2023 57:27


Toshihiro Kobayashi, Ph.D., presents his research on the mechanisms driving cell fate choices in early mammalian embryos. He also discusses the potential application of these principles in future regenerative medicine. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38328]

Science (Audio)
Induction of Germ Cell Fate from Mammalian Pluripotent Stem Cells with Toshihiro Kobayashi - Breaking News in Stem Cells

Science (Audio)

Play Episode Listen Later Oct 1, 2023 57:27


Toshihiro Kobayashi, Ph.D., presents his research on the mechanisms driving cell fate choices in early mammalian embryos. He also discusses the potential application of these principles in future regenerative medicine. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38328]

UC San Diego (Audio)
Induction of Germ Cell Fate from Mammalian Pluripotent Stem Cells with Toshihiro Kobayashi - Breaking News in Stem Cells

UC San Diego (Audio)

Play Episode Listen Later Oct 1, 2023 57:27


Toshihiro Kobayashi, Ph.D., presents his research on the mechanisms driving cell fate choices in early mammalian embryos. He also discusses the potential application of these principles in future regenerative medicine. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38328]

Authentic Biochemistry
BioMedical Portraits I. Chapter 12. Unique lipoprotein lipase mediated lipid alteration of endothelial cell function in the mammalian CNS may traffick in oxysterol binding protein linked PM-female AD

Authentic Biochemistry

Play Episode Listen Later Aug 17, 2023 29:56


References Steroids. 2022 Sep;185:109053 Trends Neurosci. 2015 Jun; 38(6): 364–374 Progress in Molecular Biology and Translational Science Volume 168.Pages 257-275 Histol Histopathol. 2018 Jan; 33(1): 1–10. --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support

The Stem Cell Podcast
Ep. 244: “The Mammalian Lung” Featuring Dr. Emma Rawlins

The Stem Cell Podcast

Play Episode Listen Later Jun 13, 2023 60:40


Dr. Emma Rawlins is a Senior Group Leader at the Gurdon Institute in the Department of Physiology, Development, and Neuroscience at the University of Cambridge. She talks about modeling fetal lung development using organoids, using single-cell RNA sequencing to create a human lung fetal atlas, and her advice to trainees to follow their hearts.

The Faster Than Normal Podcast: ADD | ADHD | Health
The Deep End + Shark Fins + ADHD” a Deep Dive W/ Free-Diver Suzy Malseed

The Faster Than Normal Podcast: ADD | ADHD | Health

Play Episode Listen Later Jun 7, 2023 19:33


Having ADD or ADHD is a gift, not a curse. Hear from people all around the globe, from every walk of life, in every profession, from Rock Stars to CEOs, from Teachers to Politicians, who have learned how to unlock the gifts of their ADD and ADHD diagnosis, and use it to their personal and professional advantage, to build businesses, become millionaires, or simply better their lives.  Our Guest today in her own words:  Suzy Malseed is a high-energy Mum of twins, a competitive free-diver, a farmer, a reformed teacher and a neurodiversity advocate. Based in Australia, originally from New Zealand, Suzy maintains a ferocious appetite for adventure and travel, having lived in 6 countries and worked and stayed in many more! We have a few things in common, but can you guess the main similarity? Yep, ADHD! Also parachutes; but you've got to subscribe and listen for that story ;-)  Enjoy and hey, thanks so much for subscribing to Faster Than Normal!  [you are now safely here ]    00:40 - Thank you again so much for listening and for subscribing! [This week we've switched to Cloudemagic.io from a slow Descript. All sorts of things are happening in Tech now, huh?!  This may be ‘the way' we go for this upcoming Summer season. Please let us know what you think in the comments?! I will be paying special attention to any feedback on this Ep, that you may share- and also of the past three Ep.s (not the tbd Ep.291)  Thank you -Ed] 01:00 - Introducing and welcome Suzy Malseed!  03:50 - Most parents when their kids are diagnosed are like, Wait- this sounds like me? 05:09 - Shrek- Ogers are like Onions Ref 06:00 - On processing your ADHD 06:37 - Peter on Free Diving. Ref: Le Grande Blue  Luc Besson [Not a Luc Besson film, but if you love the above ref, (or Philip Glass, or Portugal even, then this assistant editor strongly rec's The 100 Foot Wave. It appears to also be a podcast now! -Ed] 07:50 - On “the silence” while free diving with very little gear  Ref:  If I dive to 30 meters, that four times the pressure that we experience walking on the ground..feels like a giant bear hug, basically.  09:24 - On Skydiving joy 09:42 - do you have techniques to get your head right, to get into the zone & ready to dive? 10:52 - On meditation.  11:00 - How much does your heat rate decease when you put just your HEAD into the water? Ref: The Diving Reflex aka MDR 11:18 - What, what? Why?? Genetics??! 12:05 - On mental and physical adaptation & breaking the surface13:04- Are you good in Emergencies too? Please ell us in the comments!! [remember, we always read these at some point every few weeks] 14:04 - Is dopamine generation = wanderlust or/and wanderlust?  [US parlance + vernacular]  14:20 - What else do I and we all not know about Free Diving; but should? 16:32 - When your back-up plan is to be prepared and try harder if… there is a next time, 98 feet down. 17:26 - Do you want to see what free diving in an Underwater Cave looks like?! [We have warned you!! [Trusted respect to AL + MCH & Co. btw -Ed ;-] 18:10 - Thank you Suzy Malseed!!  “I would rather a child start therapy at an early age and learn that they're brilliant; than spend the next 30 years undoing the belief that they are broken.”  -Peter Shankman  June 7, 2023 18:14 -  How do our now Summer-shiney subscribers find out more about you?  Web:  Will update if avail. Otago Times article from 2018 is here Socials: @NoAirSuzy on:  INSTA  @SuzyMalseed on: Facebook 18:14 - Hey, you there! Yes YOU! We are thrilled that you are here & listening!  ADHD and all forms of Neurodiversity are gifts, not curses. And by the way, if you haven't picked up The Boy with the Faster Brain yet, it is on Amazon and it is a number one bestseller in all categories. Click HERE or via https://amzn.to/3FcAKkI My link tree is here if you're looking for something specific. https://linktr.ee/petershankman 17:24 - Faster Than Normal Podcast info & credits. Guys, as always thanks so much for subscribing! Faster Than Normal is for YOU! We want to know what you'd like to hear! Do you have a cool friend with a great story? We'd love to learn about, and from them. I'm www.petershankman.com and you can reach out anytime via email at peter@shankman.com or @petershankman on all of the socials. You can also find us at @FasterNormal on all of the socials. It really helps when you drop us a review on iTunes and of course, subscribe to the podcast if you haven't already! As you know, the more reviews we get, the more people we can reach. Help us to show the world that ADHD is a gift, not a curse!  [ Ed: This is a relatively brand new experiment in editing show notes, transcriptions sort of; so if you notice any important, or significant goofs we've missed here or along, please do let us know @FasterNormal  Thanks! -sb]    EXTRA CREDIT:  10 GEN-AI POINTS ABOUT FREE DIVING COVERED IN THIS INTERVIEW AND GENERATED BY AI.  1. What is free diving?  Ref: Free Diving Safety  Answer: Free diving is an activity that involves diving underwater without the aid of scuba diving equipment, but instead, relying on one's ability to hold their breath and adapt to high pressure underwater. 2. What is the process involved in free diving? Answer: The process involves a state of deep meditation to connect the mind, body, and breath. It involves getting a feeling in the body to confirm readiness and experiencing a mammalian dive reflex, which results in a 30% drop in heart rate when immersing the face in water. 3. What attracts people to free diving? Answer: Many free divers are drawn to the sport due to the sensory deprivation it offers. The sport also requires a lot of respect for the body and its ability to adapt to the demands of the sport. 4. What is the connection between ADHD and free diving? Answer: ADHD is highly represented in free diving. Many free divers with ADHD are drawn to the sport's calming effect and the sensory deprivation it offers. 5. Can free diving be a solo activity? Answer: Yes, free diving can be a solo activity, and the responsibility for success or failure rests solely on the diver. 6. What is the movie La Grand Blue about, and why is it significant? Answer: La Grand Blue is a movie about a free diver who can slow down his heartbeat and go as deep as he wants. It is one of Luke Basal's best films and launched the career of Eric Sierra and Jean Renault. 7. How does free diving compare to skydiving? Answer: Both skydiving and free diving require a lot of preparation work before the activity. The speaker puts a lot of effort into checking their gear before skydiving and even dreams about it. 8. What is the connection between risk-taking and neurodiversity? Answer: The speaker shares a love for risk-taking with their son. They both enjoy taking risks, but they are careful when doing so. This high appetite for risk-taking is much higher than the average person. 9. How was the speaker's son diagnosed with developmental issues? Answer: The speaker's son was diagnosed with developmental issues by a specialist in Singapore who observed his high energy and sensory needs. 10. Why is silence important to the speaker in free diving? Answer: The speaker experienced silence for the first time in their life when they first went underwater, and they are addicted to the quiet. The feeling of deep pressure on their body when diving is also compared to a welcoming hug. — TRANSCRIPT via Castmagic.io and then corrected.. somewhat, (Ooh-ooh! Fourth and likely final trial run is today June 7, 2023. #gen_AI_for_whut?? Peter Shankman [00:00:40]: Ladies and gentlemen, good morning from wherever in the world you happen to be. And welcome to their episode of Faster Than Normal. My name is Peter Shankman. It is 5:30 in the morning when I am recording this, which can only mean one thing. We are talking to someone and interviewing someone on the other side of the world, because otherwise I'd be on my bike right now. I want you guys to meet Suzy Malseed. Suzy is with us today, who is a high energy mom of twins, or Mum, as she puts it, which cold give you some idea of where we're talking to get this. She's a competitive free diver. I cannot wait to talk about that! She's a farmer, a reformed teacher, a neurodiversity advocate. She is based in Australia. Her two kids have ADHD. She's originally from New Zealand. She believes she has ADHD. She's a ferocious appetite for adventures and travel, having lived in six countries and worked and stayed in many more. Susie, good evening. Where you are. Good morning from where we are! Suzy [00:01:26]: Hello, Peter!! How are you? Peter Shankman [00:01:28]: It is great to have you back on the podcast. Love to talk with this. I found you because I started following you on Instagram because your Instagram is just you free diving, which is just some cool stuff. So I'm a huge fan. So thanks for taking the time today. Suzy [00:01:42]: Thank you very much. Thanks for having me. Peter Shankman [00:01:44]: So there are a lot of topics here I want to cover. Both your children, ADHD, were they diagnosed? If so, where? If so, how? How old are they? Let's start the so. Suzy [00:01:55]: Yeah, my kids are twins and they were diagnosed pretty young, particularly my son. So he was diagnosed first, which is kind of often the case because girls present a little differently. And he was diagnosed pretty early, pretty easily, pretty obvious, if you know what I mean. Right, Add? It wasn't necessarily something that I sort of went to the doctors and said, look, I think we've got some challenges. It was actually more because they were twins and because they were a little bit premy and we were living in Singapore at the time. Oh, wow. Yeah. And so singapore is amazing. It tends to be a little bit more on the clinical side, so they're very good at tracking and than sort of thing. So they were tracking growth and checking up a lot of things. And it was actually only in quite a routine sort of pediatric appointment when the specialist just saw my son literally bouncing and just said and I just said, oh, no, he's got high energy. I have too. And they just said, yeah, but there's energy and then there's energy. And I just went, oh, okay. Anyway, so we went there with Max pretty quickly, and it helped him a lot, to be honest, because it helped us to understand his sensory needs. That was probably the biggest thing that we had to get our heads around, is his sensory needs. He was very sensitive, so there was a lot of sort of putting his fingers in the ears and high pitched noises. He was very aversive to those sort of things. But he was also a sensory seeker, so he would love contact. He would love heavy contact. And once we understood that, we could do a lot of OT him. And we did a lot of physical work with him. I ran everywhere with him, on him, a scooter and a skateboard in the pool from a very young age, and his body just responded just so well to that heavy work. So I'm very grateful for understanding…. Peter Shankman [00:03:49]: Interesting. You said than you're undiagnosed, but you probably have it like most parents when their kids are diagnosed. That's how you figured out. You're like, Wait, this sounds like me 100%. Suzy [00:04:01]: I mean, as I was reading reading to learn more, to understand how to advocate for my son, I just sort of went, oh, my God. Well, that's me. And it was sort of the risk taking type stuff. I've never really put it all together, but I'm a very high energy person. I always have been. I've always had a ridiculous appetite for risk, but not in a stupid way. So from the outside, it might look like you're doing crazy stuff, but I've actually thought about everything I've done before I've done it. But my appetite for risk is certainly much higher than the average person. And I saw it with my son as well. He would jump off very high things, but he knows how to land, and that's the difference, right? Little parachute landing, and he's just not scared of getting hurt. And I've had the same thing. I'm not scared of getting hurt, which is probably quite weird, but when you've lived your whole life in the same body, you don't really realize how strange it is until you sort of put it all together. And it's like peeling an onion. As you get older, you realize a little bit more every year. Peter Shankman [00:05:09]: I always think back to that great line in Shrek. Onions are like ogres. Oh, they smell. No, they have layers. But it's very true. It's a complicated peel. It's interesting. And I talk about this all the time, which is great segue into talking about free diving. I never felt any kind of sense of release until I did my first race, until I did my first skydive, until I did all these things that allowed me to get as much dopamine as I ever wanted than I was doing stuff that would get me in trouble in school. And it'd be a nice quick hit, but it'd always come with a punishment. So, yeah, when you find that thing, it changes everything. And I'm sure your kids figured that out. Suzy [00:05:46]: Oh, absolutely. And for me, when I was at school, I mean, being a female, it's different again, like, I was the class clown, like you sort of alluded to in your book and stuff as well. It's very similar. And I never realized that I was doing it. I wouldn't have said than I was doing it to get a laugh. I was just quite flippant, and my brain just goes so fast. I would think of things very quickly. And it did get me into a fair bit of trouble, of course, but yeah. And you do realize after a while I did figure out that I was chasing adrenaline. I didn't understand that I was also chasing dopamine. So there's been a lot more come out since. Every year we learn more. So that's an interesting bit to put together. Peter Shankman [00:06:26]: All right, speaking of dopamine, let us talk about free diving. How cool. I've never done it, but I actually can't. Funnily enough, I have something called a peritoneal shunt in my spine. I can't go below like 20ft or. Suzy [00:06:40]: I'll. Peter Shankman [00:06:42]: But let's talk about free diving. I first learned about free diving high, as I'm sure you're familiar with in the movie La Grande Blue. Yes, I saw that movie in college, Add. Holy shit. Did that just captivate the hell out of me. It started my love affair with Jean Renew. If you haven't seen La Grande Blue, it's one of Luke Basal's best films. Luke Basal is the guy who did the original of Fem Nikita. Not that American bullshit, but the original version, the French version. And La Grande blue launched Eric Sierra's career and launched Jean Renault's career as well. So I strongly encourage you to check out La Grand Blue. But it is about a free diver and who just has this incredible ability to go as deep as he wants and slow his heartbeat down like something like six beats a minute. The first question I want to ask it must be I'm sure the dope mean hit is amazing, but the silence must be incredible. Suzy [00:07:39]: Yes. This is the thing. When I first went underwater was the first time in my whole life I've ever experienced silence. Like, my whole mind just went quiet. And that is what I'm probably addicted to the most, is just the quiet. I just love it. And then there's also pressure. So you're familiar with every 10 meters of depth, there's an additional atmosphere of pressure on the body right. So when we're sort of walking around on the ground, we have 1 ATM of pressure on our body. When we go 10 meters below surface, we have two atmospheres of pressure. Every 10 meters past that is an additional. So if I dive to 30 meters, I have four atmospheres of pressure on my body. Four times the pressure that we experience on the walking around on the ground. Now that feels like a giant bear hug, basically. And the really interesting thing is you either like it or you don't like it, to be honest. And I love that feeling. It's deep pressure to me. It just feels like a big welcoming hug. And that's a sensory thing for sure. So I have a few head starts, I think in terms of my natural ability to be able to be very good at the sport, sort of just drew me in from the start because I've actually been helping other people along the way. And sometimes when I watch their journey, it seems so foreign to me because it was so different to my journey. So they tell me about how scary it is and they tell me all than and I'm just like I can see that they are scared, so it's their truth. But I don't understand it because I've never had any fear around free diving. For me, it's just the most beautiful sport you could ever do. Peter Shankman [00:09:24]: I think it's the same for Skydiving when I'm never more free. Because when I jump out of that plane, I only have two options. I'm going to live or I'm going to die. That's it. Yes. Suzy [00:09:34]: Quite a cool feeling, right? Peter Shankman [00:09:35]: It is. It's wonderful. It's the most free I'll ever be. Suzy [00:09:38]: Yeah.  Peter Shankman [00:09:42]: So one of the things about Skydiving, I'm assuming it's the same with Freediving, is there is a not of prep work that goes into it. And a lot of for me, it's checking my gear, it's making sure that everything's right. The point where I have dreams about it. And my parents, once when they came to, they weren't too happy I was doing it. But when they first came to watch me, they told me were shocked at how meticulous I was because I was never that meticulous for anything in my life. And all of a sudden I'm here checking all my gear and I'm doing double check and triple check. So I'm curious, do you have routines before you go? You don't just jump in the water and dive. So do you have things that you do to sort of get your head right, to get into that zone to get ready to go? Suzy [00:10:24]: Yeah. The cool thing with free diving is we don't have a lot of gear. So that's pretty cool. Compared to scuba diving or technical diving. They have a lot of gear. They have all of that check check stuff. We don't have that. But obviously we have to go through our own process. The process that I go through is basically I would consider it. I was very deep meditation. So it is my way of connecting in my mind, my body and my breath. I get a feeling in my body and then I know I'm okay, I'm ready. Everything's like you just quieten down, everything. And then your heart rate flows. It's called a mammalian dive reflex. So every human gets this. When you hop in the water and immerse your face you'll get a 30% drop in heart rate. That's a given, right? Everyone gets that? Yeah.  Peter Shankman [00:11:11]: Wow. When you're in the water say it again, say it again. Suzy [00:11:16]: So when you immerse your face in water you get a 30% drop in heart rate. Peter Shankman [00:11:22]: That is incredible. Why?! Suzy [00:11:24]:  It's genetic. So it goes back to when we were little, whatever you think we were before. A little fishy somewhere along the line. Yes. It's called the mammalian mammal. Mammalian dive reflex. MDR. Yes, I've heard of that. Peter Shankman [00:11:39]: Okay. Suzy [00:11:39]: Yeah, no I know! Peter Shankman [00:11:40]: 30%. That's amazing. Suzy [00:11:42]: It's a big drop and so that's a real thing. So that sense of comfort and feeling like you're really supposed to be there comes over you. And then of course I suppose one of the other reasons I just love the sport so much is how much your body adapts is just you have so much respect for your body. So your body can adapt to pressure. Obviously we take one breath at the surface and that breath has got to carry us through all of the equalizations of our masks, our sinuses, our ears all the way down to the bottom and then all the way back. And the more you dive, the more you free dive, the more your body adapts to what you're asking it to do. And that happens with everything that we do, as you would know with your own body and your training. And free diving is perhaps an extreme example of that because when you take your breath on the surface and you leave, it's just you and it's like jumping out of a plane. It's just you. There's no one to blame, it's no one else, it's just you. And like you said to me, it's just so freeing. I go very silent and very quiet in that response. And are you good in emergencies and things like that. Like do you have that same sort of response where whenever everyone else panic. Peter Shankman [00:13:04]: I'm perfect in emergencies I'm terrible at real life.  Suzy [00:13:07]: Exactly. Peter Shankman [00:13:08]: But throw an emergency there and I'm the guy you want. Suzy [00:13:11]: Correct? Yeah. And I'm exactly the same and I figured that out along my life as well. Everyone. And when I was a kid I used to tell myself, I don't know why, but I live in opposite land and that's just how I prioritize it on my head. So someone else would go yay, we're having a massive party. And I would go oh my god. Peter Shankman [00:13:28]: Exactly. Well you know, you just made me realize something. I think that part of that might be because when you're in an emergency, you don't have time for social anxiety. There's never any small talk in the emergency. Suzy [00:13:40]: True. Yeah. Peter Shankman [00:13:42]: I just realized that there's no small talk in emergency. It's get shit done now. Suzy [00:13:46]: Yes. And we can be who we really are, like instead of niceties. And the other one I wanted to touch with you is travel. So I know that you're a massive traveler and I'm the same and quite extreme stuff as well. Probably when I look back in it, I have an appetite for that. And I think it boils down to the same sort of really ridiculous survival instinct which I quite enjoy, which is basically you're only going to eat when you figure out how to go get the food that you want to get and how to make yourself understood. Peter Shankman [00:14:16]: That's kind of a cool thing very much. I love that. What else? What am I not asking you about? Freediving? I don't know enough about it to know what to ask you. What am I not asking? Suzy [00:14:29]: Okay, so I think that ADHD is quite highly represented in free diving, to be honest. When I consider other free divers and I look around I see a lot of people who are like me and I believe that we're all drawn to the sport for the same reason, which is like a form of sensory deprivation, if you know what I mean. A lot of times we're actually diving in black water and that freaks some people really out. But we just close our eyes and I suppose how do you do that? Well, you have to find a way to surrender. You have to understand than the more you relax, the better your dive will be, the more tense you are, the worse your dive will be. So you have to switch off and there really is no choice. And if anything happens when you're under the water like I've had a couple of little incidences along the way. I had this time when I was swimming through a wreck and it was a fun dive with some other free divers and as I was going through the wreck and coming up through the wheelhouse, the back of my fin came off and I was sort of like it just came over me. I'm like, oh my God, I'm 30 meters down. I've already been here for at least a minute and now I only have one fin. If I panic, I'm toast. And you just go through that process and you're like, right, I have to cross my legs to make you can picture yourself crossing your legs and than do the dolphin movement to make your one fin work and just get yourself to the surface fast. And you just know that you have no space for panic so you have to stay calm. Peter Shankman [00:16:10]: I'm panicking listening to that story and I get it. I mean, you're in a position like same thing with Skydiving. Knock on wood. I haven't had to use my reserve yet, 500 jumps, but I'm sure at some point I will and I'll know what to do. But yeah, I mean, I guess it's that premise of what is your other option? Right? There is no other option. Suzy [00:16:30]: That's right. There's no other option. Peter Shankman [00:16:32]: Add, it's interesting because we worry about I'm sitting here, I'm listening to you. I'm like, Jessa, Christ, it's 98ft underwater, and she loses a fin. And I'm thinking you can't stop to get it right. You just sort of have to let it go. And so, okay, do what you have to do. Right. And this is what you train for. Suzy [00:16:50]: That's right. Peter Shankman [00:16:51]: And again, there's no small talk. There's no, oh, what would you rather do? There's no oh, honey, I don't know. What do you want to eat tonight? No, it's get out. Yeah, right. So you make than work. No, it makes perfect sense. But Jessa, 98ft of door. It's it's so funny. The only thing that that really physically scares me to the point where I can't even watch it is these guys who do sunken wet cave diving where they wear the air and they go into these ridiculously tight. And there's always a story, like people who have died doing that. I'm watching them skirt through these caves that are like they have half an inch above them. They have to take off the air bottle and put it next. What is wrong with you people? Yeah, I'll go jump into a perfectly plane because I'm not going to get Stuck through the middle of the earth, Jessa. Peter Shankman [00:17:47]: But, yeah, I get the freedom. I totally get the freedom that you feel it. But again, Steven, free diving is more freedom because you're not stuck in between the middle of the earth. I don't know. Suzy [00:17:56]: That's right. Peter Shankman [00:17:57]: Anyway, I want to be respectful of your time. Suzy, this was amazing. What a great story. I really like to have you back, if at all possible. Next time I'm down under, next time in Australia, I'm coming to visit, no question about it. You can take me out of the water. Peter Shankman [00:18:09]: That would be awesome. Suzy [00:18:10]: Absolutely. Yeah. We've got some nice things. Peter Shankman [00:18:12]: Thank you so much for taking the time. I really, really appreciate it. Suzy [00:18:15]: Thank you, Peter. Keep up the good work. Peter Shankman [00:18:17]: Thank you, guys. As always. Faster Than Normal is intended for you and yours! Shoot me, email. Let me know you want to hear. Peter Petershankman.com. I'm at Peter Shankman everywhere but Twitter, because Twitter sucks. Now, Add, if you're on Blue Sky, you can find me there, too. Let us know what you want to hear faster than most for you. We'll see you guys next week. ADHD is a gift on a curse, and I'd rather here's my new quote. I would rather a child start therapy at an early age and learn that they're brilliant than spend the next 30 years undoing the belief that they're broken. We'll see you soon, guys. Stay safe.  — Credits: You've been listening to the Faster Than Normal podcast. We're available on iTunes, Stitcher and Google play and of course at www.FasterThanNormal.com I'm your host, Peter Shankman and you can find me at shankman.com and @petershankman on all of the socials. If you like what you've heard, why not head over to your favorite podcast platform of choice and leave us a review, come more people who leave positive reviews, the more the podcast has shown, and the more people we can help understand that ADHD is a gift, not a curse. Opening and closing themes were composed and produced by Steven Byrom who also produces this podcast, and the opening introduction was recorded by Bernie Wagenblast. Thank you so much for listening. We'll see you next week! 

Quirks and Quarks Complete Show from CBC Radio
Antarctic dinosaur migration, permafrost and pollution, tracking shark births, Moana's tools, the Pangenome, and Zoonomia mammalian genome projects

Quirks and Quarks Complete Show from CBC Radio

Play Episode Listen Later May 19, 2023 53:44


Giant dinosaurs found in Australia migrated through Antarctica; A map of arctic industrial pollution shows where risks might arise as permafrost melts; A new technology is showing where baby sharks are born; Polynesian tool finds support the oral histories behind Moana; Incorporating diversity of human genomes in new Pangenome; Comparing 240 mammalian genomes helps illuminate what makes us human.

Biohacking Superhuman Performance
Episode #151: Dr. Bill Harris: Fatty Acids and The Omega-3 Index

Biohacking Superhuman Performance

Play Episode Listen Later May 2, 2023 83:00


Did you know your omega-3 levels can be predictive of good health outcomes and cholesterol levels? An Omega-3 Index of 8% or higher is ideal, yet most people have a percentage of around 4-6%.    Today we're discussing why it's important to measure your omega-3 levels, and what you can do to optimize these levels. Plus, we'll answer the question: is there a relationship between fatty acids and longevity?   I'm joined by Dr. Bill Harris, PhD, FASN, President of the Fatty Acid Research Institute and Founder of OmegaQuant Analytics. We're diving into omega-6s and omega-3s and discussing the benefits of these fatty acids and where they come from. We also cover the importance of maintaining a ratio of omega-6 and omega-3, and whether or not omega-3s have an effect on blood clotting and blood circulation.   Dr. Harris has been a leading researcher in the omega-3 fatty acid field for over 40 years. He has more than 300 scientific papers on fatty acids and health, the vast majority on omega-3. He has been on the faculty of three medical schools (Universities of Kansas, Missouri (at Kansas City), and South Dakota), and has received 5 NIH grants to study omega-3. He was the co-author on three AHA statements on fatty acids and heart health. As the co-inventor of the Omega-3 Index (and other omega-3 blood tests) and founder of OmegaQuant Analytics, Dr. Harris has been ranked among the top 2% of scientists worldwide based on the impact of his research.    What we discuss: 00:02:38 - Omega-3s and their effects on blood clotting and blood circulation  00:07:23 - The value of omega-6 00:11:54 - The ratio of omega-6 and omega-3 00:18:03 - Where do arachidonic acid and linoleic acid come from, and what do they do? 00:21:32 - The signs and symptoms of omega-6 deficiency  00:25:22 - The components of omega-3s 00:31:04 - EPA and DHA   00:41:35 - Is there a relationship between omega-6 and omega-3 levels and longevity? 00:46:31 - Fish as a source of omega-3  00:57:21 - Mammalian sourced omega-3s 01:01:34 - What should people be looking out for in their supplements?  01:06:35 - 3 things to keep in mind about omega-3s and omega-6s    Key Takeaways: Looking at levels of omega-6 fatty acids in the blood can predict future diseases like heart disease and diabetes. Higher levels of linoleic acid in the blood are associated with lower risk for these diseases.  Increasing your levels of omega-3 is more important than worrying about getting your omega-6 levels down in order to have a good ratio between the two. It is also important to focus on EPA and DHA when it comes to types of omega-3s. It's important to measure your omega-3 levels. These levels are predictive of good health outcomes and even cholesterol levels. Oily fish like salmon and mackerel are great sources of omega-3s. Find more from Nathalie: YouTube: https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ Facebook: https://www.facebook.com/groups/462749384302295 Facebook Group: https://www.facebook.com/groups/biohackingsuperhumanperformance Instagram: https://www.instagram.com/nathalieniddam/ Work with Nat: Book Your 20 MInute Optimization Consult: https://calendly.com/nniddam/intro-call?month=2021-08 Find more from Dr. Bill Harris: Website: www.omegaquant.com, www.fareinst.com  Facebook: https://www.facebook.com/Omega3Index Instagram: https://www.instagram.com/omega3index/?hl=en LinkedIn: https://www.linkedin.com/company/omegaquant-analytics/?viewAsMember=true Twitter: https://twitter.com/OmegaQuant YouTube: https://www.youtube.com/channel/UCZhRX5MX7-dFLXNZjsjhKKw About the Sponsors: Mitopure: Use code NAT10 for 10% off your order at https://www.mitopure.com/ LMNT: https://drinklmnt.com/ Berkeley Life: Use my code NIDDBL for 10% off at berkeleylife.com  

The Ezra Klein Show
The chemistry of connection

The Ezra Klein Show

Play Episode Listen Later Apr 27, 2023 53:06


Could our brains make us less lonely? Sean Illing talks with psychiatrist and author Julie Holland, whose new book Good Chemistry takes on the crisis of disconnectedness we face today. They discuss the brain chemistry of attachment and human connection, how psychedelics can be used both in therapeutic contexts and to help us feel more connected to others, and the toll that this crisis of isolation can take on us — emotionally, physically, and spiritually. Host: Sean Illing (@seanilling), host, The Gray Area Guest: Julie Holland, MD (@BellevueDoc), psychiatrist; medical advisor to MAPS; author References:  Good Chemistry: The Science of Connection from Soul to Psychedelics by Julie Holland (Harper; 2022) "Work and the Loneliness Epidemic" by Vivek Murthy (Harvard Business Review; Sept. 26, 2017) "Loneliness in U.S. Subsides From Pandemic High" by Dan Witters (Gallup; Apr. 4) The Red Book by Carl Jung (written from 1914–1930; pub. Norton; 2009) "People would rather be electrically shocked than left alone with their thoughts" by Nadia Whitehead (Science; July 3, 2014) "Mammalian central nervous system trace amines" by Mark D. Berry (Journal of Neurochemistry; vol. 90 (2), July 2004) "The connection between oxytocin and autism, explained" by Peter Hess (Spectrum; Jan. 6, 2022) Moody Bitches by Julie Holland (Penguin; 2016) "Youth Suicide Risk Increased Over Past Decade" by Farzana Akkas (Pew; Mar. 3) "MAPS predicts FDA approval for MDMA-assisted therapy in 2024" by Brian Buntz (Drug Discovery & Development ; Jan. 27) "Psychedelics May Be Part of U.S. Medicine Sooner Than You Think" by Jamie Ducharme (TIME; Feb. 8) Alex & Allyson Grey "Can magic mushrooms unlock depression?" by Dr. Rosalind Watts (Medium; Feb. 28, 2022) How Psychedelics Can Help Save the World by Stephen Gray; foreword by Julie Holland (Park Street Books; 2022) Enjoyed this episode? Rate The Gray Area ⭐⭐⭐⭐⭐ and leave a review on Apple Podcasts. Subscribe for free. Be the first to hear the next episode of The Gray Area. Subscribe in your favorite podcast app. Support The Gray Area by making a financial contribution to Vox! bit.ly/givepodcasts This episode was made by:  Producer: Erikk Geannikis Engineer: Patrick Boyd Editorial Director, Vox Talk: A.M. Hall Learn more about your ad choices. Visit podcastchoices.com/adchoices

The Birthful Podcast | Talking with Pregnancy, Birth, Breastfeeding, Postpartum & Parenting Pros to Inform Your Intuition
Helping Your Mammalian Body (and Baby!) Have an Easier and More Connected Birth

The Birthful Podcast | Talking with Pregnancy, Birth, Breastfeeding, Postpartum & Parenting Pros to Inform Your Intuition

Play Episode Listen Later Apr 26, 2023 50:36 Transcription Available


During labor, you want contractions that are longer, stronger, and closer together. But why? Dr. Sarah Buckley and Adriana take a deep dive into the amazing and fascinating hormonal dance that happens during the birthing process, and how interventions such as synthetic oxytocin or an epidural can lead to a cascade of interventions that negatively impact the process for both the birthing person and their baby. They also talk about ways to support the physiology of birth (regardless of what path it takes) in order to help fill any ‘hormonal gaps' that may occur.Get the most out of this episode by checking out the resources, transcript, and links listed on its show notes page.  If you liked this episode, listen to our interview on Your Baby, The Mammal, and our episode on Epidurals and breastfeeding.You can connect with Sarah on Facebook at drsarahbuckley. You can connect with us on Instagram at @BirthfulPodcast and email us at podcast@Birthful.com. If you enjoy what you hear, download Birthful's Postpartum Plan FREE when you sign up for our weekly newsletter! You can also sign-up for Adriana's Own Your Birth online BIRTH preparation classes and her Thrive with Your Newborn online POSTPARTUM preparation course.Follow us on Goodpods, Apple Podcasts, Amazon Music, Spotify, and anywhere you listen to podcasts.Our Sponsors:* Visit HomeThreads.com/BIRTHFUL today and get a 15% off code for your first order!Support this podcast at — https://redcircle.com/birthful/donationsAdvertising Inquiries: https://redcircle.com/brands

Her Brilliant Health Radio
Tame Your Anxiety And Have A Happy Brain: Lessons From The Mammalian Kingdom We Can All Use

Her Brilliant Health Radio

Play Episode Listen Later Feb 9, 2023 46:34


Have you been wondering how to manage anxiety, especially in midlife? Dr. Loretta Breuning is here to provide us with the answers! Join us on the latest episode of The Hormone Prescription Podcast and learn how the lessons from the mammalian kingdom can help us all have a happy brain. Not only will you learn about how hormones work within our bodies, but also gain insight into how simple changes in our environment can drastically change the way we feel.   Dr. Loretta Breuning, PhD, is the Founder of the Inner Mammal Institute and Professor Emerita of Management at California State University, East Bay. She is the author of many personal development books, including Habits of a Happy Brain: Retrain Your Brain to Boost Your Serotonin, Dopamine, Oxytocin, and Endorphin Levels and Tame your anxiety-rewire your brain for happiness and others.   As a teacher and a parent, she was not convinced by prevailing theories of human motivation. Then she learned about the brain chemistry we share with earlier mammals and everything made sense. She began creating resources that have helped thousands of people make peace with their inner mammal. Dr. Breuning's work has been translated into twelve languages and is cited in major media. Before teaching, she worked for the United Nations in Africa. Loretta gives zoo tours on animal behavior, after serving as a Docent at the Oakland Zoo.   In this episode, you'll learn: - How the mammalian brain works - The hormones that can affect your emotional state - Simple strategies to rewire your brain for happiness and reduce anxiety - How our environment plays a role in affecting our moods   Listen now to this powerful episode with Dr. Loretta Breuning and learn how you can have a happy brain!   (00:00): Nature is designed to habituate to the emotions that we already have. Stay tuned to find out why our happy chemicals are not designed to be on all the time.   (00:13): So the big question is, how do women over 40 like us, keep weight off, have great energy, balance our hormones and our moods, feel sexy and confident, and master midlife? If you're like most of us, you are not getting the answers you need and remain confused and pretty hopeless to ever feel like yourself Again. As an ob gyn, I had to discover for myself the truth about what creates a rock solid metabolism, lasting weight loss, and supercharged energy after 40, in order to lose a hundred pounds and fix my fatigue, now I'm on a mission. This podcast is designed to share the natural tools you need for impactful results and to give you clarity on the answers to your midlife metabolism challenges. Join me for tangible, natural strategies to crush the hormone imbalances you are facing and help you get unstuck from the sidelines of life. My name is Dr. Kyrin Dunston. Welcome to the Hormone Prescription Podcast.   (01:07): Hi everybody, and welcome back to another episode of the Hormone Prescription with Dr. Kyrin. Thank you so much for joining me today. Today we're gonna be talking about stress. Again, I know it's such an important topic, but we're gonna be relating it to your happy neurochemicals. We're going to be talking about dopamine and serotonin and oxytocin and endorphins and how you can optimize these neurochemicals for your hormonal and overall health and wellbeing, how you can get out of anxiety and many other things. She has a unique perspective that's comes from the animal kingdom, which we're a part of, but we're a little bit different and we're gonna talk about how we're different and how that affects our health and ways that you can manage your neurochemicals that other animals don't need to worry about. I'll tell you a little bit about her and then we'll get started.   (02:05): Dr. Loretta Bruning is a PhD and she's founder of the Inter Mammal Institute and Professor Erta of Management at California State University East Bay. She's the author of many personal development books, including Habits of a Happy Brain, retrain Your Brain to Boost your Serotonin, dopamine, oxytocin, and Endorphin levels. And the author of Tame Your Anxiety, rewire Your Brain for Happiness and other books. As a teacher and a parent, she was not convinced by prevailing theories of human motivation. Then she learned about the brain chemistry we share with earlier mammals and everything made sense. She began creating resources that have helped thousands of people make peace with their inner mammal. Dr. Bruni's work has been translated into 12 languages and is cited in major media before teaching. She worked for the United Nations in Africa and Loretta gives zoo tours on animals' behavior after serving as a docent at the Oakland Zoo. Welcome Dr. Loretta Bruning to the podcast.   (03:05): Hi. So nice to be here.   (03:07): I'm really glad to have you here. I think people are dealing with so much stress right now. Stress levels are at an all-time high and we can't talk about it enough. How can people get regulated out of the stress site, be happy in their lives, experience joy? I mean, after all, I think that's what we're here to do ultimately, but there are a lot of things that get in the way and I'm curious if you can share with everyone how did you get interested in brain neurochemical chemicals and how to have a happy brain? What was your path?   (03:42): Like many people, I grew up around a lot of unhappiness and I didn't have a good explanation for it. So I think I was always curious like, what is everybody so upset about? So I was always looking for that and nothing ever seemed like a good enough explanation. I studied academic psychology my whole life, so I knew all the theories, but they still didn't really explain it to me and especially becoming a parent and you think, okay, now gonna start over and we're gonna do everything right according to the book, you know? And I was like, no, that doesn't work. Kids are unhappy. My students were unhappy. So then I had to rethink what I had learned and I stumbled on a lot of animal studies monkey studies, and that triggered, you know, cuz when I was like 18 years old and started studying psychology, there were a lot of monkey studies and that's what got me into seeing that the chemicals that make us feel good are the exact same chemicals in animals and they're controlled by brain structures that animals have too. And to me, that explained everything first because a monkey is constantly making decisions. What's gonna make me happy? Oh, if I get that banana, how can I get it? And that's the job our happy chemicals do is reward us for those actions. And then that this whole animal brain is not capable of using language. So it's totally separate track from the stuff we're telling ourselves in words.   (05:20): Yes. You know, I think that we forget that we are animals and that we have the same brain structures as other animals and that our brain is really designed to keep us alive, but some of those systems can act negatively in humans and actually make us sick when we don't understand them and use them properly. And I think this is super important for women at midlife because we've kind of, most of us been using our brains and our systems unconsciously, and we don't really start paying attention to how they function until we hit midlife. And the cumulative negative effects start encroaching on our good health. And then we wanna know, oh my gosh, I don't feel well. And we discover that our brain neurochemistry is part of the reason why we don't do well. How can we work with it differently? So can you talk a little bit about the different brain structures and kind of how our neurochemistry works and then we can kind of dive into what people might be encountering in terms of maladaptations of these systems that causing them problems? Sure.   (06:36): So you've raised so many good issues and I'm gonna try to simplify. Sure. Get to the point as much as possible, but there's so much. So I always like to focus on the positive, you know, what can we do instead of just focusing on the problem? So the reality is that our happy brain chemicals are not designed to be on all the time. You hear about dopamine, serotonin, oxytocin and endorphin and you think, oh, other people must be just getting this all the time and what's wrong with me? And yet, when you know the job these chemicals do, you know that their job is only to be on for that moment to spark you into action when that action is appropriate. So for example, like a lion is looking around for something it can eat and if it runs after everything, it's not gonna get anything and it's gonna die of starvation.   (07:30): So dopamine turns on when it sees something it can get, and that's what our good feelings are like for that appropriate moment. So when we're not having that spark of joy, it's like no big deal. That's to the self-acceptance of my brain is designed to go up and down to navigate where should I use my energy? What's a good opportunity? And the other part of that is, well, how do I know what's a good opportunity and where should I use my energy? Well the amazing thing is my dopamine pathways are built from my own dopamine experience in my past. And your dopamine pathways are built from your past. So every little toddler is like trying to get that ball and get that cookie. And yet we're all building our pathways from our unique individual experience. And when I know my own pathways, that liberates me from being limited by them because you may think, oh, the only way to feel good is by repeating this behavior that triggered my good feelings in the past. But when you know that it's just a pathway, then you say, oh, there are thousands of other ways to be happy. I'm just doing this one because that's just the accident of my past experience.   (08:50): Yeah, we really are very programmed throughout our lives as to what's gonna make our dopamine reward pathway go up, what's gonna make our serotonin go up. It's gonna differ for every person. But I totally identify, and maybe you listening identify with this too, that I do wanna be happy all the time. Loretta . What's wrong with that? And you know, I think we see other people maybe on social media or friends that we have who really do seem like they're happy all the time. Why can't we be happy all the time?   (09:25): Okay, that's a great question. So first let's distinguish happy chemicals from unhappy chemicals. Okay, so I don't want to feel like I'm gonna die in every minute. So that's, yeah, like in in the animal brain, you are trying to escape from predators and starvation and the human brain is capable of imagining predators that are not actually there. That's how we stress ourselves. So we feel like we gotta run from this predator all the time, and that's horrible feelings. So absolutely, we should definitely wanna get away from that because that's the job our brain is designed to do is escape that threat. But if I want to feel joy every minute of every day, that's not realistic and I'm gonna end up disappointing. And if I tell myself that everybody else is feeling joy every minute of every day, then I'm gonna end up, you know, feeling left out. So, you know, there's this current movement of trying to feel the pleasure of small things. I think that's great, but the way the brain works is it habituates to what you already have. So if I think, let's say if I only get a date with this one person, I'll be happy forever. But then once you get the date with that person, you're not happy forever. Right,   (10:53): . So   (10:54): If you think, oh, if I only get this promotion, I'll be happy forever. But you get the promotion and you're not happy forever. So the reason is that our brain is designed to habituate to rewards we already have. So it's like saying that when my ancestors were hungry and they thought, oh, if I only found a tree full of riped fruit, I'd be so happy I'd, you know, I'd never be unhappy again. And they'd find the tree and they'd stuff their face with riped fruit. But if that made them happy forever, then they would not get any protein. They would not search for water and firewood. So our brain is designed to focus on the unmet need and to take for granted what you already have and say, okay, been there, done that. Now what else can I get? So that's the norm , which   (11:48): Yeah, I think everyone can relate to that. And I remember when I was younger, I would always think, I will be happy when, fill in the blank, you know, when I graduate high school, when I graduate college, when I graduate med school, you know, when I get married, when I have a baby. And like you would get to that and you do get that initial boost of, oh my gosh, this is so great, I'm so happy. And then it just becomes a factor of your life and it doesn't give you that dopamine kind of hit or serotonin boost. So I know everybody listening can really relate to that. And I love that you explained it, the nature's design to habituate to the emotions that we already have. And it is does confer survivability not only on the animal kingdom, but humans, which we're a part of the animal kingdom, but I think that sometimes we think we're superior because we have these huge four brains and that we should be able to surpass that. So how does someone who's maybe feeling dysthymic or even depressed really start to work in their lives to change their neurochemistry to a more positive state where they can get those boosts?   (13:03): Sure. So first is to understand that whatever triggers the happy chemical is based on not what you're telling yourself in words and philosophical abstractions, but it's a real physical pathway built from past experience. So a simple example would be, you know, if you give a child a cookie when they do a certain behavior, they're gonna repeat that behavior. So even if you're sad on some level, you got rewarded for being sad in your past. Mm-Hmm. because you felt like, well now I'm doing my share in carrying the load by being sad or something like that. So once you say, my sadness is a real physical pathway in my brain, my feelings about what it takes to turn on a reward chemical, those are real physical pathways in my brain. And I can build new pathways to have new expectations about how to turn on my happy chemicals. But it's hard to build new pathways in adulthood. It's exactly like learning language. When you're a child, you learn language easy. But if you try to study a foreign language in adulthood, it takes a lot of repetition and it feels like real work. And that's what it takes to build a new path to happy chemicals when you're older. Okay. One example.   (14:30): Sure. Yeah, that would be great.   (14:32): So, so the typical example would be negative expectations. Like if you think people don't like me, nothing I do works. Everything I, everything goes wrong in my life, you know, every, everyone can look for that o, that whatever is their own loop. And then look for, well, how did that pathway get built in my past? And then every time I feel it to say, oh, it's a real physical pathway, what other pathway could I have that would feel better? So my personal example was I always felt like people were criticizing me. Like I would jump to that conclusion all the time on no evidence at all. And then I would feel basically the terror of my childhood of being attacked and criticized. So what other pathway would I like to have will to just say other people are fine with me and I can feel good whether or not I have their approval. So I tell myself that, and the first time I do it, it sounds wrong and stupid and unbelievable, but I know that I, if I repeat it over and over and practice it, that I will build a real physical pathway in my brain and then it will just feel like my new normal.   (15:51): Okay, yeah, I love that. So we can change our neurochemistry studies have clearly documented that I know that some people listening deal with a lot of anxiety. You know, as our hormones change at midlife, when our estrogen starts going up and our progesterone starts going down, which can happen as early as 35, but definitely starts happening from 40 to 50. And by the time you hit menopause, you're really solidly in that category. You lose that ameliorative effect of the progesterone, which is the anti-anxiety hormone. So a lot of women at this stage of life deal with a lot of anxiety. What are some tools that we could start to use to help mitigate that?   (16:38): Sure. So to boil it down to one word that I use is called legacy. So legacy means my sense of what I can create that will live on after I'm gone. And the reason for this is if you think that we have this big human brain attached to this animal brain, so the animal brain is programmed to just search for survival and to fear survival threats. But my big human cortex can abstract and think about the future and it knows that I'm not gonna survive and there will be a future that will go on without me. And that is terrifying. And we can terrify ourselves all the time. Now, in the world of our past people died young, but they had children young. So if you had children like at 16, then you'd be a grandma at 32 if you lived that long. And so when you saw your grandchildren, you had a sense of legacy because you taught them how to chop vegetables and you saw them do it, and you had a sense of yourself living on after you're gone.   (17:46): So that was your legacy. And there was no, no birth control. So people were so busy taking care of children that they didn't have time to worry about dying as much, and they, they couldn't call 9 1 1, they couldn't get lab tests. So they just focused on like the next emergency of, you know, a kid's crying, how can I get food? And now like we don't really get to watch our grandchildren grow up for so many reasons. So we don't have that automatic sense of legacy. So we have to constant, consciously create a sense of legacy in one way or another.   (18:23): Yeah, that's, that's an interesting concept I hadn't thought about, but creating something for the future. And you're reminded me about the short lifespan that just a few hundred years ago we have, and I, I think it would be so interesting to see a study about people's ability to be in the present a few hundred years ago when they knew they were only gonna live, you know, 30 or 40 years. I bet that really focused them on, I gotta make the most of this time Yes. That I have. Whereas now we've got, you know, on average, I think 82 years in the US as the American lifespan for females. And I don't know about everybody else, but I feel like I waste a lot of time because it's like, oh, I won't do that thing now because I've got another, you know, few decades where I could do it. Whereas if I only had 32 years, well my life would've been over a while ago, but it really would've focused me. How do you think that has changed over time?   (19:25): Well that's, you know, to focus on the positive again. Yeah. Pause is a time when you say, geez, if I wait to be happy, I may wait too long. , you know, and so is it worth wasting another minute of my life worrying about X, Y, and Z? And you could make good arguments with your conscious verbal brain, oh, I should worry about X, Y, and Z. But then you could say, you know what? I could let it go because I'm not gonna get back the time that I waste on that. And also there's a lot of fearful images about the future, like even though I may live till X number of years that I'm gonna have a decline. And if you focus on that, then you're gonna be feeling the decline now. Mm-Hmm. . So it takes a real conscious effort to redirect yourself, you know? And like every time you see a wrinkle, for example, to instead of seeing that wrinkle as evidence of decline to say, this wrinkle gives me permission to stop worrying about X and to just start being happy. Now,   (20:34): I'm glad you brought this up. I recently came across an article in my newsfeed about the high demand for older aged female models. Recently there's been a boom and even 70 and 80 year old female models, right? Everybody is really starting to honor older women, their wisdom, which is what I think we really is the gift of menopause, is that the wisdom that we carry. We have lived long lives, we've seen a lot. I remember an attorney telling me once that when he went to jury trials and they did the voir deer where they select the jury, his favorite jurors were older women. And I asked him why. And he said, because they have been there, done that, seen everything. But they also have a lower ego and the maturity to understand the nuances of guilty, not guilty issues, which some younger people don't have. So all this to say also, I see in your bio, you've done a lot of interesting things. It says that you used to work for the United Nations in Africa, so you've lived a lot of life, you're at a certain stage outside of the work that you do with helping people to boost their neurochemistry. Just from a personal perspective, what would you share with the audience that would say, what are your biggest lessons learned at this stage of life, looking at life that that might be meaningful to them?   (22:08): Sure. So first we say, I have power over my own brain. I'm not gonna be happy from something outside myself. So if I wait for the world to make me happy, I'm gonna wait too long. . So what can I do to make myself happy? But of course we all know that that doesn't mean short-term happiness. Like you sit around and eat a pint of ice cream. So how do you balance this long-term versus short-term? So I talk about having a long-term goal, a short-term goal, and a middle-term goal. And in order to reach your goals, a lot of times, well, so a short-term goal is like I can reach it today, so I'm gonna get some hit of dopamine every day. That nice sense of accomplishment by setting a realistic goal, by breaking down what I want into small steps that I could actually do.   (23:00): And then the other part is like to achieve long run goals, I might have to do some things that are uncomfortable. So what can I do about that uncover? Well, instead of getting into like a cortisol spiral where you know I do something that feels bad and then that triggers another bad feeling and another, and another, I say to myself, okay, I'm gonna do this thing that makes me uncomfortable. I'm only gonna do it for five minutes. Or what, whatever's that reasonable chunk to tackle that obs obstacle. And then, you know, if I were gonna have a cup of coffee and a cookie anyway, I need to save it until after I've done that difficult thing. So that whenever I have it down, that I have an up that I can look forward to. And I have plenty of ups that have no calories, which in my life is comedy. But people can find their own.   (23:52): I love comedy cause laughing is so good for your neurochemistry . Yeah. Talk a little bit about laughing and what are some of your favorite things, ways to engage with comedy? Do you like standup movies? Like how do you get laughter in your life and what does it do for your neurochemistry?   (24:10): Sure. So laughter triggers endorphin, which is the body's natural opioid. And this is a widely misunderstood chemical. So an opioid is there to relieve pain and in the state of nature it's triggered by real physical pain. But because we have deep belly muscles that we don't use much, when you have a belly laugh, you get a little bit by giving those muscles a workout and you only get a little bit, but then you can laugh more and get a little bit more and it's the only healthy way to get them really, or the main healthy. And I explained this all in my books, so the way I get it. So I don't like bitter angry comedy and it's hard for me to find like truly uplifting comedy. And I know that if I look for comedy when I'm in a bad mood and like nine outta 10 of them are gonna be bitter, then I'm gonna just end up feeling worse, right? So I keep what I, I call, like when you're on a diet and you fill your pantry with healthy snacks mm-hmm. . So I fill my pantry with healthy comedy and I have a list of things that are ready for a bad day. So I know that when I'm in a bad mood, I have something uplifting that I could go to and I, I make that list on some other day rather than waiting until I'm in a bad mood.   (25:32): Yeah, I love that. And I love to laugh too. So one of my favorite go-tos I'm gonna share with everyone cuz you can use this, is I found this TV channel I, I'm sorry I don't re exactly know what it's called, but it's all videos of animals unscripted, they call it. Oh,   (25:49): I didn't write that down. .   (25:51): It's animals just doing what animals do mostly pets, right? Pet cats and dogs. They are hilarious. So it's just one video after another with no narration, no introduction of pets and Anna, there are some birds and different lizards and things doing the crazy things that animals do. So I'm gonna put a plug for that. And I'm also gonna put a plug for a re a movie I saw recently, I think it's from New Zealand that I think is hilarious. It's called The Breaker, uppers and . I literally laughed out loud so many times in that movie. So I gotta put a plug in for that. But I agree with you, laughing is huge. Another thing I wanted to touch on is that, you know, a lot of the people, women I work with, this might be you if you're listening, they're not so much concerned with their own worries, but worrying about others in their lives and what other people should be doing and trying to control them. And this one has to do this and what if they, what if my kid, you know, moves across the country to another state with my grandkids and then I won't be around them and they want to control what everyone else is doing. They're worrying about what everyone else is doing. You shared this quote with me before we started about it says, it's hard enough to manage your own brain, so stop trying to manage other people's brains. So I'm wondering if you can talk a little bit about that.   (27:18): Sure. So the feeling that I can only be happy if other people do X, Y, and Z, that my happiness depends on them. If you think that you'll never be happy . So it's just, you just gotta make a deal with yourself. I'm gonna be happy no matter what anyone does. And the simple way to do that, if I give you a visual image, if this other person does something and I think, oh no, I can't be happy because they're doing that, is I'm imagining that there's only one path to happiness and that person is blocking the path. But instead I'm gonna think there are thousands of paths to happiness and if this person blocks that path, I'll just find another P.   (28:04): Yeah. So stop focusing on everybody else . And you know, and it goes along with that same desire I used to have, well I'll be happy when this happens For me, that happens for me. And a corollary is I'll be happy when X person stops doing Y or X person starts doing why. And really I have decided at this point in my life that happiness only happens in the now when I'm happy with myself. And it really doesn't have anything to do with anything to do with what anyone else does. And I can choose that. Yes,   (28:41): I I a way of saying that. I always say my husband gets on my nerves, but it's my nerves . So, but it's fine. I, it's my job to adjust my own nerves to love him for what he is. And I don't even have to love him in any specific way. That's my job to just decide,   (29:01): Yes, to decide it's a decision. I know the name of your company's inner Mammal Institute and you take people on zoo tours to see animals behavior and I'm wondering if you can share with everyone, what does that do for the people who participate? How does it enrich their understanding? Sure.   (29:21): So I learned so much by watching nature documentaries and the simple fact of life in the interest of time, I'm just gonna say it straight, like animals are quite nasty to each other. And I learned that from watching nature videos. And yet what I learned from academic social science is that the state of nature is all peace and love and something has gone wrong with our world, but that's just not true. So we have this animal nature which is very motivated by self-interest and we really struggle to manage and navigate and control this inner mammal that is just wanting to grab the next banana. So how can I manage my inner mammal? And like I always feel like other people wanna grab my banana. That's easy to see. But what about my own impulse to get another banana and my feeling of like they took that banana at my expense.   (30:20): That's how the mammal brain works. So nobody likes to see this in themselves, everybody wants to see it in other people. So that's why we really need to be exposed to the reality of animals. Now to tell you the truth, you don't visually see that in the zoo because the pet world is not the same as the state of nature where animals are not fed. They have to get their food, they have to hide from predators. So the zoo tour is really a fun way to talk about this. But if you watch the nature videos of David Attenborough, especially his early series, then you really get get the facts. And I got them then from that like evolutionary biology books is how, and I have a reading list on my website and it's all in, in all of my books. I put this in a simplified form of why animals are nasty to each other and how we can feel it and manage it and relax with   (31:21): It. Yeah, you know, it's interesting, I just came back from four months in Africa and went on safari a few times. So I got to see those wild animals in their natural habitat habitat. And it was very instructive to see how they work both communally but also very selfishly in some ways. And I saw what good boundaries the animals had because at certain points in their existence, well for instance the wiles at one point we were driving up to, so in this Serengeti, or no, we were in the in goro goro crater in Tanzania. And most of it was extremely dry so there wasn't a lot of vegetation for a lot of the animals to eat. And then we came upon this place where there was a river and it was very green and lush and there were almost no animals there. And I said to myself and to the guide, why don't they just come over here and eat and drink water?   (32:22): And he said, because the lions know that that's where the animals are gonna go to eat and drink water. So they're afraid. And then I saw this group of will to be standing right outside this lush area and they were all huddled together facing the same direction. And one was out in front and he said, you see those will to bees, they are discerning. Is it safer, is it not? Where is the sun in the sky? What is the wind doing? What time of year is it? Is the lion gonna attack us now is it safe to go drink the water and eat or no? And so they were working communally, but then other times you would see them when there actually would be food and one would be pushing the other to try to get more of the food or more of the water. And so it was very interesting to me to observe that. Well   (33:14): I love those guides because they tell you the truth. Yes, don't get from academic psychology because academic psychology constructs this unrealistic, idealized world of peace and love, which is not what nature is about. And you get it from those tour guides and and you can get it without if you can't go there. You know, nat, a lot of some nature videos, you know, some of them are still hooked on the, the other unrealistic belief. But another simple example about the wildes that I learned from a nature video. So in order for them to get from, you know, they follow the grass year round, you probably saw how they migrate to wherever the grass is, but they have to cross a river and while they're crossing the river, they could die from a crocodile, they could die on the other side, you know, from a predator and then they could die when they jump in because another will toes could jump on top of them.   (34:15): So it's very difficult to make that decision. When am I gonna jump? They'd really rather not jump cuz the crocodile might get them, but if they don't jump, the rest of the herd piles up behind them and pulls them in and then they don't even get to jump, they just get shoved in with without balance. So they're constantly making this very difficult decision and you could see your own terror of like when you're a kid, like, do I jump or not? And so even what looks like herd behavior is a constant calculation of how much do I follow, how much do I, you know, take a step in a different direction. And our brain is making that decision every minute of every day. Am I gonna just follow the guy in front of me or am I gonna take a different step in a different direction? And you're calculating that with your best guess, which can never be perfect.   (35:09): Yeah. And I love what you said earlier about the fact that other mammals don't have the ability to imagine danger and humans do. There's a great book I wanna share with everyone called Why Zebras Don't Get Ulcers that clearly explains why zebras don't get ulcers, they don't have the imagination faculty and they really go through a process after they are stressed. So for instance, we, we saw this crazy wild chase of a leopard going into a herd of various types of gazelle like creatures and how they responded and, and I really got to see what's outlined in that book firsthand where these animals, when they go through a stress like being chased by a predator, they have a discharge process that they go through afterwards where they shake, and maybe you can talk a little bit about this and how it might apply to us. They go through a process to discharge that stress and reregulate their cortisol stress hormone, which I talk about all the time. This is really what's killing us. So how can we take that instructive information from a zebra's behavior and use it for our superior mammalian brains?   (36:23): Sure. You're also referring to, and and it's slipping my mind, there's a a book by another guy Levine about this shaking that goes on. So the idea is they discharge the stress and then they go back to what, what do they go back to? And this is what I talk about in my anxiety books. They go back to meeting their survival needs because if they just worry about predators all the time, they're gonna starve to death. So if they say, I'm not going out into that world unless it's a hundred percent safe, then they would to death. So hunger motivates them to deal with risk, to deal with potential danger to go out and meet their needs and only worry about danger when it's really there. Now the big human cortex says, oh no, that's stupid, I'm going to anticipate threats and avoid them. But if you spend your whole life anticipating threats and avoiding them, you're gonna just worry constantly.   (37:26): That's because our basic needs are met, that our lives are so comfortable that we could just stay home and do nothing unless we think it's a hundred percent safe. And one thing I blame this on, that's funny, I'm a bit older than you, I think I remember the years when, so cars broke down all the time and people said, oh, American cars are so bad, we should do what the Japanese did. And this is what I taught in the early years of my academic career. So the Japanese had this way of anticipating things that will go wrong in the production of a car and solving it at the source, fixing it at the source. And they said, that's what we have to do. We have to anticipate defects and fix 'em at the source. And so the whole education went on this bandwagon of anticipating threats and figuring things and preventing them so that quality would be a hundred percent and that had value, but it really made people nuts because now people think nothing can ever go wrong. We anticipate every possible threat and they literally, it's called the Toyota method that every tiny defect is a crisis because if you don't fix it now you're gonna produce a thousand more cars with the same defect. So you have to treat it as a crisis. So we were all indoctrinated to treat every tiny little problem as a crisis.   (38:51): Yeah, I think that's a great example. And you know it's done well for the car industry, but as a human species we really can't live that way. And thank you for saying that about the the worrying. Cuz there was something I was worrying about this morning and as we're talking, I'm thinking, why am I worrying about that? If it becomes a problem, I'll deal with it. I'm not gonna worry about it now   (39:16): . Yeah,   (39:17): Yeah. So can   (39:19):I give you another example of this that I think is very common? So let's say you get an email that asks you to go to some website and do this or that, and let's say it's something that you wanna do. So okay, I'm gonna do it. So you go to that website and you think, oh, this'll take five minutes and then a half hour has gone by and you still haven't done it. And like somehow I get really upset when I can't get something technical to work. It's really the problem is that I'm connecting it to every failure in my past is a real pathway in my brain. So one little failure today activates that old pathway like it's my failure pathway. You have your failure pathway. And what triggered it was really the expectation that I could do it in five minutes. So all I could do is just tell myself this is something hard, it's gonna take a while, and then all of the problem goes   (40:15): Away. Right. No, I love that. It really is how we frame the problems that we have. It's not the problems themselves that are the problem. What you think is the problem is not the problem, it's how you're thinking about the problem. So our thinking is always the problem. I know you have some great resources for everyone, but before we wrap up, I'm wondering if you could talk a little bit about the importance of oxytocin. That's another hormone. I don't think we talk merely enough about its importance and how to nurture our oxytocin.   (40:47): Sure. So in the animal world, animals seek groups for protection from predators. And in the oxytocin is the chemical that rewards you when you feel protected by a group. But this has been idealized in an unrealistic way in the current human dialogue. So we think that we should be protected all the time. And in fact, that's true for babies and that's why, as you know in the medical profession that oxytocin is central to maternal birth and lactation. But in the adult world, you're not meant to get this protection that you got as a child. So oxytocin moments are difficult and rare. Now how do I get my oxytocin moments? Well, whatever triggered my oxytocin when I was young built real physical pathways that tell me how to get it today. But that's also quite limiting. So the famous example is if you smell the cooking that reminds you of trust and bonding moment of your youth, then you seek that you want that, you think that will make you happy.   (41:57): But what we really want is protection. And in the adult world, we're never gonna get the protection of a child. And even when you were a child that protection was not perfect. So we have to accept that I have this natural logging for protection and I'm only gonna get moments of it rather than to have this perfect protection. So a simple example of a moment of it is people go to a concert and they're in this building with like thousands and thousands of people, whether it's music or a speech or an athletic event that you feel like you're sharing something that's important to you, but they're not really protecting you. Another example is if I tell my life story to a train a stranger on a plane, they're not gonna be there for me in the future. So it's like you look for these trust moments because letting down your guard is what is the oxytocin feeling? And what was so impactful to me, I learned that reptiles only have oxytocin when they're mating, which lasts for 10 seconds and the rest of the time no oxytocin because they don't trust their fellow reptile. So oxytocin is that feeling that I can barely tolerate your presence just enough to reproduce .   (43:24): . That's hilarious. , yes, oxytocin. I mean, people may know it as being the hormone that go is what causes labor in women, but it's also involved with milk production and bonding and connection and it interacts with your other hormones as well. So I'm gonna leave you all with a mandate to do something with your oxytocin today. What could you do to get some oxytocin just on a daily basis? You know, I think the past few years where a lot of us have been so isolated, we were legally bound in some instances, to not leave our home for much really has put a toll on our oxytocin, which unbalances our entire hormonal neuroendocrine cascade. So getting back to normalcy where we have in-person human interaction is key. So I want to challenge everybody listening to do something about your oxytocin to boost it going forward. And Loretta has a lovely gift for you and we'll have a link in the show notes to it. Do you wanna tell them a little bit about your download anxiety? What turns it on, what turns it off?   (44:41): Sure. It's a free book, P d F. It's the shortened form of my larger book, which is called Tame Your Anxiety, rewiring Your Brain for Happiness and Explains something. We haven't talked much about cortisol, the chemical that gives us the survival threat feeling and to sort of accept our own cortisol. It has a natural job and then to get real about the ability to manage it rather than to just let it take over and spiral.   (45:12): Awesome. Well thank you so much for that free gift, Loretta. If you are dealing with anxiety, I invite you to click the link in the show notes and learn what you can do to start taming your anxiety. Thank you so much, Loretta, for joining us for an episode of the Hormone Prescription Podcast.   (45:33): Sure. Thanks for the great   (45:34): Questions and thank you for joining us today. Hopefully you will implement some of the things that we've discussed so that you can move towards greater hormone balance and brilliant health. Thanks again and I'll see you next week for another episode of the Hormone Prescription Podcast with Dr. Kiran. Until then, peace, love, and hormones   (45:54): Y'all. Thank you so much for listening. I know that incredible vitality occurs for women over 40 when we learn to speak hormone and balance these vital regulators to create the health and the life that we deserve. If you're enjoying this podcast, I'd love it if you'd give me a review and subscribe. It really does help this podcast out so much. You can visit the hormone prescription.com where we have some free gifts for you and you can sign up to have a hormone evaluation with me on the podcast to gain clarity into your personal situation. Until next time, remember, take small steps each day to balance your hormones and watch the wonderful changes in your health that begin to unfold for you. Talk to you soon.   ► Get a FREE copy of Dr. Loretta Breuning's Anxiety: What turns it on, What turns it off. CLICK HERE to sign up.    

Muscle Medicine
Cold Immersion & Breath Work for Hashimoto's w/ Kristin Weitzel

Muscle Medicine

Play Episode Listen Later Nov 7, 2022 54:24 Transcription Available


Episode SummaryWelcome to this week's episode of Thyroid Strong where Kristin Weitzel is having us sit in ice baths for our minimum effective dose of cold. That could be 30 seconds, a minute, or even longer. With each ice bath we take, the list of health benefits gets longer. Key TakeawaysCold immersion has huge benefits for our physical health but also for our emotional health. It will help us boost energy, lose weight, and reduce inflammation. It will also help us sleep better and manage stressful situations easier. Kristin Weitzel is giving us a lesson we all need to listen to and how to start that lesson today with a few DIY tips for making your own ice bath at home.The Experience of a Cold Immersion and its BenefitsThe most painful moment of the cold immersion is the expectation it is going to be cold before you immerse. Choose your coverage of clothing and begin your breathwork. Start small and over time increase the length of exposure. The goal when you get out of the ice bath or cold body of water is to have a shiver response. This experience is designed for your body to learn to manage high stress and to quickly adapt to its environment.Using Cold Immersion in your Daily Routine to Help with Hashimoto'sCold immersion can help with Hashimoto's two biggest struggles, fatigue and losing weight. In solving fatigue, plan your cold immersion around getting rest. The ice bath will down-regulate your system and allow it the opportunity to rest, so partake in an afternoon nap or do it right before dinner to go to sleep shortly after. Hashimoto's other biggest struggle of losing weight is also remedied with every cold exposure. The ice bath boosts the production of our brown adipose tissue which then eats our white fat tissue, resulting in weight loss.In This EpisodeExperience of a cold immersion [1:49]Reverse engineer the nervous system using your breath [4:24]Mammalian dive response [5:00]What happens when you get out of a cold immersion [7:25]Minimum effective dose, what is yours? [8:30]Cold immersion and Hashimoto's [10:33]Benefits of cold immersion [13:59]Cold immersion and solving fatigue, when to do cold exposure [15:43]Boosting brown adipose tissue to reduce weight [18:06]Cold immersion versus cryotherapy and other options [21:12]Breath work in getting into an ice bath [22:48]How an ice bath teaches you to manage stress [25:00]Joints and inflammation and cold immersion [30:46]Ways you can DIY your ice bath [33:19]Converting a chest freezer for an ice bath [35:25]Trainings for cold immersion [42:25]Quotes“This mental component coupled with dopamine and adrenaline that's hitting your body and it is having you understand from a brain chemistry and a physical capacity that you are, okay, you're in control.” [5:59]“The goal is to get out and have somewhat of a shiver response.”[9:45]“Sleep is one of the biggest wins of cold exposure.” 12:58]“The biggest health boosts that we can receive for our bodies when it comes to mitigating disease, come in immersion.” [21:12]DISCLAIMER THIS PODCAST/WEBSITE/COACHING SERVICE DOES NOT PROVIDE MEDICAL ADVICE. The information, including but not limited to text, graphics, images, and other material contained, are for informational purposes only. NO material on this show/website/coaching practice/or special guests are intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of YOUR physician or another qualified health provider with any questions you may have regarding medical treatment. Never delay seeking medical advice...

The Bledsoe Show
Tolerance Sucks with Mike & Max

The Bledsoe Show

Play Episode Listen Later Jul 25, 2022 87:58


00:00.00 Max Shank All right? Welcome back to Monday morning with max and Mike we're talking about launch pads. We're talking about ramps. We're talking about Trebuches. We're talking about flinging things a mighty distance this applies to both physics and also business That's what I'm excited about. I don't want to go out there and go fishing. You know one pole at a time I want to be able to deliver a tremendous payload at a great distance. You know what I mean and have it create a very massive effect. But in order to do that. You got to spend a lot more time with the building of it. It's like fishing pole pretty easy to build water wheel significantly harder to build but greater impact lot more work ahead of time and then you take it all the way to something like a rocket which can or a power plant. Can deliver a tremendous amount of power but it requires a huge amount of upfront work and because I've done a lot of biz coaching with people I feel like that that is the number None thing that. Separates people who create an exponential growth in their business is the ones who are willing to do the setup time to make something that is a more sophisticated leverage and force multiplier. You know what? I'm saying. 01:27.51 mikebledsoe Yeah I Think the None thing you got to consider in that case is does what you want to build actually solve a problem and um I think a lot of people you know think I think a lot of people start businesses based on something they Like. Or something you know around what it is that they want to do which works sometimes because they figured out. They've solved some problem for themselves and they they can help other people through a product or service. Um, but I'm a big fan of of seeing if it's the right Poll. Before I go launch a hundred of them like I don't want to put the wrong bait on my hook I could be I could be catching the wrong fish or I could be catching no fish at All. So I would use one pole make. 02:16.13 Max Shank I like I like the fishing analogy. The fishing analogy is good because people are about as smart as fish. 02:24.18 mikebledsoe Ah, it's true. Ah so no, but like it's good to put figure out if if it you know test with one poll or maybe test with 20 polls all with different bait. What um, keeps popping off is now we're pulling the hooks out and we're replacing all them with that one Bait I think that. That's like the I've been thinking about the business as ah, especially like a coaching business as a triangle at the bottom you have you have your offer and then one of the sides is marketing and the other sides is the fulfillment. The coaching aspect. Find that most people and the way this would work is like what are you selling? How do you market it and then how do you fulfill on it whether it's a coaching business or not and. 03:12.98 Max Shank Ah, right? How do you? How do you educate them about it and how do you get it to them. So like the bottom is what is it and then one side is how do you tell the right people about how do they know about it and then how do you get it to them I like it. 03:19.16 mikebledsoe Right. 03:25.32 mikebledsoe Exactly exactly so but I find them I know you do triangles are the best sturdy pointed can penetrate well and super hard to tip over. 03:31.46 Max Shank Also I like triangles. 03:36.87 Max Shank So I mean they're not hexagons. But they're really cool. 03:44.95 mikebledsoe Ah, so well depends on what kind of time go with oh let's hear it. 03:46.11 Max Shank You know my favorite ah Buckminster Fuller joke he's ah he goes ah is well. It's more of a statement I guess he goes. Ah why do architects build square houses. So engineers can put triangles in them. 04:08.49 mikebledsoe I I like it I like it. Yeah yeah, tons of triangles. Yeah, None of triangles. Yeah yeah, without that your shit's going to get fucked up. So um. 04:10.73 Max Shank And if you you've done a bunch of house framing and stuff like that too before right? So you have these rectangle boxes that are just full of triangles. You better have those fuckers in there. 04:28.22 mikebledsoe Well, it just won't even look right. 04:31.44 Max Shank No oh it's going to go over without some triangles in there. Yeah. 04:32.86 mikebledsoe Just kind of push it over Ah yeah, so I like thinking about this because I more often than not when I bump into an entrepreneur either a new entrepreneur or an entrepreneur suffering None times out of None It's the the bottom. Part of the pyramid. It's the offer. It's the it's the what they're selling. Um, yeah, yeah sand at the beach. Yeah, and so so somebody you know it's like somebody has these air things people think that it's a marketing problem. 04:55.12 Max Shank Sand at the beach like why would you want to do that to yourself. Ah yeah. 05:10.66 mikebledsoe And I'm like it's not a marketing like does anyone want what you're selling in the None place when it's not a marketing problem like your offers should be the thing you're offering should be an obvious solution if it's not obvious solution then there's more work to be done there. Um, some people in business would say that the development of the offer is a function of the marketing department. Which I don't necessarily disagree disagree with but so is the fulfillment. They kind of all bleed into each other. Yeah, So so if you so if you nail down a solid offer and then you just. 05:33.74 Max Shank I Think marketing marketing is part of the offer for sure. Yeah. 05:49.30 mikebledsoe Funnel as many people towards that that one offer not now you got a winning formula. 05:53.48 Max Shank Well, and even even better. Is you you set up your shop within a current flow of consciousness directed at that specific thing and I mean Youtube has been a game changer in this because. There's just such a bigger library of things that are searchable if you have questions that need solving and if you if you meet people where they're at and you match their pace. They don't notice that you're a fisherman. Basically you just kind of enter the conversation that they're already having. 06:16.72 mikebledsoe Yeah. 06:31.96 Max Shank And the the finesse of that offer is really.. It's the same as seduction for the most part. That's why so many of these great copywriters were like pickup artist stuff before then because it's all about getting someone from I don't know. To yes, right? And so however, you craft that that story that is entering that person's mind is going to guide their next decisions. 07:02.20 mikebledsoe Yeah, what are we talking about toy forgot about our topic since you made it you may you you made it up. Ah oh yeah, oh. 07:09.95 Max Shank Triangles we were talking about lot. No no, we were talking talking about launch pads launch pads rocket ships trebute none fishing from fishing poles to ah nuclear power plants. Ah we're we're just trying to eat and fuck right. That's really what it comes down to we want to make sure that we're safe. We want to get enough calories. We want to continue our genes we we insist that the genes get carried forward every animal and plant is like None sure about that part of the equation like definitely more of us and we just that's life baby more of us. Ah so it's all about energy. It's all about conserving calories. It's always it's also about um, expanding the mass. 07:49.71 mikebledsoe That's life. Yeah I. 08:05.26 Max Shank Of the tribe which is also like a stored energy kind of calorie thing. It's like ah it's like the size of the tribe is your energy bank and actually in dune they talk about how the tribe shares the water ah like everybody shares all the water and then if 1 guy dies they suck the water out and like it's all about. 08:07.27 mikebledsoe Yeah, um. Yeah, about if. 08:23.63 mikebledsoe Well, it's ah yeah I mean unless you have a tribe where half of the tribe ah is useless Now that's a drain on the energy. 08:24.97 Max Shank Just ah pooling those re pooling those resources. 08:36.65 Max Shank True but that has happened for a long time I mean we we ah well and it's and it's ah it's uncertain of what the utility is in some of those cases like ah, there's that grandmother idea where there's the wisdom that. 08:40.64 mikebledsoe I Know that's why I bring it up. 08:56.24 Max Shank Passed on like why would I'm not saying this to be crude, but like why would a lady stay alive and go through Menopause like why would they stop being able to bear children and maybe it's ah like physical. Ah. Power but I think ah that is only exhibited and I think like Orcas and elephants. There aren't that many creatures that go through Menopa and maybe chimps. Also I can't quite remember exactly but it's this idea that there's a ah huge value to. 09:25.88 mikebledsoe Um. 09:33.55 Max Shank Them teaching the next generation how to do stuff and with orca they have different hunting techniques based on where they live they have different languages between these different pods. So there's a utility that's not strictly. Ah, hunting gathering or procreating. But I know what you're talking about too. It's like the bigger the percentage of freeloaders are the heavier. The wagon gets and it's still and a simple energy equation right? If you have one ah hundred kilograms in the wagon and you have None guy pulling. It's. Totally fine. But if you suddenly have ten Thousand Kilograms unless it's very ah, good piece of machinery that None guy won't be able to move it. 10:15.94 mikebledsoe Yeah, it feels like that's where we're at now. So a bunch of people are just jumping in the wagon and not pulling it. But I'm not yeah and um, while'm not blaming them I get it I get it. Well here's the thing. Ah if you lack if you lack. 10:25.46 Max Shank Um, hard to blame hard to blame. Yeah yeah, who would very few wouldn't do that. 10:35.90 mikebledsoe If you lack the skills to demand a certain amount of money I mean this is what happens we're in inflation right now and but like. 10:42.82 Max Shank Oh God here we go again. It's all it's all just about show me a better offer. That's what it's about because if so to be a freeloader to be a freeloader. It's got to be a better offer than the other thing that you are thinking about doing. 10:48.50 mikebledsoe It. It's It's exactly right. 10:55.85 mikebledsoe Exactly always goes back to incentives with you as well. But the thing is what we have is ah the cost of living is outpacing salaries. So it's not like people's salaries are inflating at the same rate that that's historically. 11:00.75 Max Shank Totally. 11:14.28 mikebledsoe Been untrue. So like what is true is that the salary state. You know you'll get a 1% raise and you get your dopamine hit and you stick with it but inflation is 10% and so your lifestyle keeps decreasing the people at the top get more money and then so I think a lot of people are just like. 11:15.00 Max Shank Right? ah. 11:29.48 Max Shank Right? Well if. 11:34.22 mikebledsoe Why I can't pay my bills at Fifteen Twenty dollars an hour I can't pay my bills so why work you know it's so I get it. 11:38.50 Max Shank Right? right? Don't totally I there's like ah a Bob Newhart joke from like a really long time ago where he talks about working at the ah unemployment office and. He it didn't take him too long before he realized that he was handing out these $60 checks and he was only getting fifty bucks a week and he had to he had to be there all week I mean this has been going on for a long time and the thing that has increased people's quality of life has been technology and maybe quality of life is actually a stretch because I think that you can perhaps live a much higher quality of life with some lower tech. 12:26.57 mikebledsoe Well ah, technology technology allows us to leverage its leverage to increase power. So if you put the if you put power in somebody's hand who's going to make choices that don't take them towards a higher quality of life. They're actually going to go to a lower quality life. 12:29.52 Max Shank Even though you know there are people you know what I mean exactly more leverage. 12:45.88 mikebledsoe Much faster and because there's dopamine that's associated with the tool the technology the dopamine will create the illusion that their lifestyle is improving because now they got a fancier phone or whatever the fuck or more people like their their photo today. 13:01.21 Max Shank Um, well they're using that tool but they're just using it at a very like low level way. 13:05.46 mikebledsoe Ah, and so so like they think they think that having the tool They think that having the tool is the increase in quality of life when it's the thing that can increase the quality of life exactly. 13:20.52 Max Shank It's not the tool. It's what you do with it. That's what like all like every every girl I've ever met has always said that to me, it's not about the tool itself. It's what you do with it. But. 13:26.56 mikebledsoe Um, and making you feel better. How the yeah so that's it's not the size of your tool max. 13:33.14 Max Shank Ah, yeah I don't know I don't know why I Assume it's ah like this with everybody. That's what I've been told I've been told that so much so much I Wonder if it is though if they're just saying that like. I Just meet all of the most considerate ladies ever. Is there a common denominator here that I haven't considered who so so we're talking we're we're we're talking. 13:54.66 mikebledsoe Ah, oh he's going into reflection folks. Ah, we'll see him back in a week absolutely 14:05.93 Max Shank We're talking money though. Also right and the size of your wallet is way more important than the size of your genitals fellows for the record fat guys with tiny cocks fat old guys with tiny cocks are out there right now with the most beautiful women in the world If that's your if that's your thing. 14:11.11 mikebledsoe When it when it comes to getting getting and having ladies. 14:23.98 mikebledsoe Yeah, yeah. 14:25.19 Max Shank You know Beauty is in the eye of the beholder. But the truth is how you do professionally and how you ah carry yourself is going to be way more important and that kind of leads us back to the launch pads. It's this. It's the same kind of thing. Can you defer the gratification. 14:33.11 mikebledsoe Yeah, you know I um. 14:43.72 Max Shank To build what is necessary so that it has its its own momentum without you pushing it all the time and I think that's what what everybody wants or at least everybody I think maybe should want is something that. 15:00.25 mikebledsoe Yeah, there's um, man see if I can find it real quick. Nope Um I was thinking about the ah the myth of it takes money to make money. There's like that that famous phrase. 15:00.60 Max Shank Can sustain itself. 15:16.61 mikebledsoe It's a meme that floats around in in our culture and it's It's not true. It's ah you need resources to make money and money is also a byproduct of using those resources well and ah you are your primary resources. 15:16.79 Max Shank Um, yeah. 15:36.53 mikebledsoe Um, are basically your ability to observe critically think and problem solve and most people I bring that up because I don't want people to get stuck in the way of thinking that oh I need to have money before I can make money because I think a lot of people. Or or in that mentality by that's exactly right? It's exactly right? So I think that there are certain common phrases out there that are almost intended to keep people from being successful and that's one of them. 15:56.89 Max Shank I Need to lose some weight before I join the gym. 16:09.15 Max Shank Oh almost or certainly I mean there's mind control everywhere um depends how deep you want to go down that rabbit hole. But even just ah like let's say regular Tv especially as a dude. 16:12.46 mikebledsoe Most certainly? yeah yeah. 16:27.99 Max Shank It's like how many Tv shows have you seen in your life where the father was a powerful figure with a good set of values and a good. It's ah it's never that it's like some whiny bitch. It's like some whiny bitch like. 16:39.83 mikebledsoe Not since the early sixty s. 16:47.15 Max Shank Who's always like oh can we have sex wife and the wife never wants to and the guy always does and in reality and in reality in reality. It's like as soon as you get to that age. It's the exact fucking opposite. Are you kidding me like None 50 year old ah in a couple. 16:50.10 mikebledsoe That is interesting I never thought about that. 17:06.69 Max Shank It's not going to be the guy who's like scrounging for it all the time he's done. It's just it's just a funny ah example where it's not just the commercials. It's just it's not like those rap videos and all that stuff That's ah mind controlling us. It's even um. 17:09.82 mikebledsoe Yeah. 17:26.61 Max Shank Like a Tv show where that's your model that you see and believe and now you think oh that's normal. Not this other thing and whatever you think is normal. That's what you're going to like reinforce. 17:32.32 mikebledsoe Yeah I've thought I've thought about this is I remember the first movie I went and saw in a theater I was five years old I don't remember seeing it but my mom told me that the first movie I saw was bambi and. 17:49.51 Max Shank Ah. 17:51.43 mikebledsoe And like I remember growing up and hunting and then people were like oh but you're going to kill bambi you know and I and I was always like well yeah I mean and I think that ah Disney movies are probably primarily responsible for veganism. At this point. 17:58.67 Max Shank If yeah. 18:09.57 Max Shank What whoa somebody saved that clip Jesus What a claim is off the wall I Love it go on. 18:09.76 mikebledsoe Is and. 18:13.35 mikebledsoe Well but it's well I mean so if we're talking about mind control and programming how many Disney films have talking animals that have the consciousness of human beings right? And so now what you have is a bunch of adults that think that the animals. Are equal to humans and there's nothing different about the 2 of us and they're people too and these are the types of things that you would most people would never be able to come to that conclusion unless they were None None 3 4 5 none watching animals talk and. This and that I'm not saying that animals don't think and don't have feelings and all that stuff but they're not us. 18:57.89 Max Shank I think the main difference is the talking thing I was thinking about this the other day like for example, it's okay, in some cultures to to eat ah a dog right? and and here it's totally okay to eat a pig. And right now that's fine. But if you were to have sex with a pig people would I think that's illegal I think it's ah or at least frowned upon if it's not illegal if it's not illegal. It's at least frowned upon in today's day and age it's because there are a lot of bigoted people out there who are discriminating against the yeah. 19:22.57 mikebledsoe I Think it's too legal. 19:36.84 Max Shank Beastie Alllet Tours I don't know whatever now picture this tomorrow tomorrow. You know what really grinds my gears is that Ah now imagine tomorrow Switch flipped pigs can speak english. 19:38.39 mikebledsoe Got a bone to pick max. Um. 19:52.54 mikebledsoe Ah. 19:56.22 Max Shank My guess is that the rules would exactly flip I think if pigs could speak English It would be perfectly legit to have sex with them and not okay to eat them anymore I think it's all about whether they can communicate. 20:08.35 mikebledsoe Well that that falls right in line with the Disney thing if you're witness lobsters having conversations with squirrels then you know like I can see what could happen for you anyways. 20:23.13 Max Shank Which one was the lobsters and the squirrels. 20:27.16 mikebledsoe Yeah I was mixing up my movies. So the back to the triangles and fishing poles the the max and I were talking about right before the show is we we would like to put together something. People are listening to this show. They like it I've gotten a few dms of people offering to send us money which we still haven't set up the donation page yet, but it'll get up eventually and um, watch should be None of those things where. 21:00.56 Max Shank Please please I'm hungry Please I'm hungry I'll eat I'll eat food. 21:02.10 mikebledsoe Thousands of dollars start rolling in and I'm like ah I should have set this up max is he's he's losing weight a pound a week right now he's gonna be nothing here by by Christmas and. 21:18.89 Max Shank I'm going on a food strike until those donations start rolling in. There's no way I'm doing that. Ah, okay, so we got the triangle We got the offer. 21:22.57 mikebledsoe No, ah so ah so I'm curious I'm curious about what it is that people people want I'm always curious about what is it that people want. Yeah oh well, a I look both. 21:36.60 Max Shank Our listeners or or all people. Okay I'll tell you what they want it goes back to um my my 3 levels theory here lizard mammal wizard people. 21:41.99 mikebledsoe Both So okay, let's go. 21:56.32 Max Shank In Lizard mode. They just want to be safe. They just want food. That's it. They're stuck and if you don't get out of that lizard Brain Mode. You're fucking lizard and you might thrash Around. You might have some sharp fangs and claws. But you're not going to fuck around with love or self-actualization which are the. Higher orders of thinking right? you go to the None tier which is the Mammalian brain the mammal wants to be loved So the lizard wants to be safe. The mammal wants to be loved and of course people will try to substitute ah food for love if they can't find it. At that level. So Let's just go back a step and so if people can get love I'm just always shoveling ice cream trying to fill the void in my heart with frozen cream out of a cow. Ah I Love it. Okay, so. 22:36.72 mikebledsoe This explains your ice cream habit. 22:54.55 Max Shank You get love as a mammal.. That's what you want and if you can go even beyond that your Self-actualization. You're following your Bliss. You're finding the intersection between doing what you feel totally blissed out doing you're in a flow state and it's good for the tribe. And you're safe. All that stuff is happening. You feel like you are expressing your most authentic or unfiltered self that feels good and of course in order to get to that point you usually need to be safe so secure The lizard Love the mammal. Free The Wizard. That's what people want and the form it takes can be different. Um you know sex and food and whatnot. 23:39.39 mikebledsoe Yeah, that's what they that's what people want they want they want safety love and after that it's yeah, um, be their best self. 23:48.30 Max Shank Self self actualization legacy. Maybe yeah. 23:53.72 mikebledsoe Find a lot of people hit self-actualization and want to help other people get the self- actualualization but don't There's not enough people. It's like we've had ah we've hit a tipping point or like ah we've slid back in society a bit good correct. Yeah enough people. There's not enough people that are. 24:03.22 Max Shank What do you mean? there aren't enough people who are trying to self-actualize or. 24:13.44 mikebledsoe At that point I think with the last couple years. Ah people slid back into survival and so a lot of a lot of the ah lot of people stopped spending money on things that were more in alignment with self-actualization and started. 24:15.61 Max Shank Ah, yeah, oh yeah, yeah. 24:31.61 mikebledsoe Buying more toilet paper now now we're in a depression. 24:32.70 Max Shank Word totally and it's interesting. How the word so closely mirrors the way that people feel when they're um, less Expressive. I Really hone in on that juxtaposition or that comparison between um, shoot I Just lost my train of thought depression expression. Yeah, exactly so being able to fully express yourself like I have a little note Card. It's just a. 24:53.33 mikebledsoe A. 24:58.85 mikebledsoe Depression expression. 25:09.97 Max Shank A small list. It's in ah, a copy of the doubtaging. It's like pocketsized and I realized a while ago for business for fitness the the list of of stuff should be pretty short overall like the general list that you follow through on and for me, it's like. Have sing I have dance I have climb I have swing like a sword or a rope or something like that. So I Just have these like little bullet points. Basically for what I want to do on a daily basis and the more I sing and dance the more expressive I feel and the less. Feel like filtered or damped down and the word expression itself is all about standing out. So It's like to stand and to be like expressed and it's um, it's important to harmonize that I think with. 25:50.59 mikebledsoe Yeah, yeah. 26:07.40 Max Shank A feeling of oneness So like the exact opposite of expressing this expressing this unique ah sensation of an individual self and sync back in to the all-encompassing soup. 26:20.92 mikebledsoe Yeah, it can be done takes practice hold both. Um. 26:27.51 Max Shank Oh yeah, you were talking about how we're in a depression now and I don't know if it's that far yet. It's not ah I'm like. 26:35.24 mikebledsoe Yeah, well, there's there's more jobs available than there are people willing to work the jobs and. 26:42.56 Max Shank Now that that sounds like Greece a few years ago where it was like 50 I don't know if there's exact statistics but it was like just an overwhelming amount of people who were working in the government and an overwhelming amount of people who were just getting paid by the government and there was like nobody left who wanted to work. 26:57.69 mikebledsoe Yeah, well there I think it's just this. Ah this is one of those and this is just one of those times where you're. 27:02.23 Max Shank And I get it. 27:09.65 mikebledsoe In in business you have to be really good at having that solid offer you actually need to be solving a problem because I think yeah luxury items luxury services be the first to go. 27:18.50 Max Shank The less necessary. It is the sooner. It goes gone depending on the demographic. Yeah, and then it almost never changes for them. 27:28.50 mikebledsoe Um, unless unless you're serving the 1% and never changes well people. 27:36.40 Max Shank It's more individual changes. It's like ah individuals slide in and out of the 1% but as a group the 1% is always there. They're always super wealthy and it always has been since alpha males. 27:44.64 mikebledsoe Um, yeah, in fact, even during it during it during a downturn. They become even more wealthy and that's. 27:52.55 Max Shank Yeah, because they have the dry powder to be able to build rocket ships while you're just fishing furiously in the stream with your one pole because you're like fuck I I need to catch None fish today to feed my family I ain't got time to be building a fucking water wheel or a rocket ship or any of that. So you're just furiously swinging your pole in the water and what about him. 28:12.36 mikebledsoe This makes me think about ah Jeff Bezos talk about a guy talk about a guy who like set the plan in place. He may not have known he was gonna do what he's doing now but he was a online bookstore. 28:23.60 Max Shank Did. Amazing! amazing. 28:29.75 mikebledsoe That just slowly added more and more categories of shit to sell and now oh no, they they probably dwarf any other retail. There's no retailer that stands a chance against them. So. 28:36.26 Max Shank Here. 28:45.27 Max Shank Um, they're so there's they have such incredible economies of scale because they can provide such a crazy value now right? They have that bulk. 28:52.97 mikebledsoe Well I think I point that out because I think people think about scale before they think about solving the 1 problem he solved the 1 problem which is you can't find a book at your local bookstore right? once he once he crushed that then he had the ability to to scale. Both. 29:00.25 Max Shank I see. Right. 29:12.87 mikebledsoe Vertically and horizontally. 29:14.64 Max Shank Yeah I mean I remember him saying once people never want something to arrive slower. They never want it to be more expensive and he's like we just basically focus on that and it's not quite like Youtube. Um, but he's connected the buyers and the sellers in a marketplace he is the marketplace and he's got such a huge market share and the delivery. So actually one of the sides of the triangle you were talking about which is the delivery. 29:37.87 mikebledsoe Yeah, um. 29:53.11 Max Shank Of that offer or that good or service to the person is I mean what's better. What's better. You can get it same day. You can get it 2 day for free and usually it's a pretty seamless process to return that shit like you go into a coles you fuck. They. 29:56.77 mikebledsoe Yeah, the feature. 30:11.78 Max Shank You print out a label 1 ne-click ordering I mean there's a lot of utility there and it's all software based for the most part that's what's so great because we know that's outrageous leverage and of course Youtube has created um, created a marketplace. Right? A media marketplace where the creators like you and I and the advertisers also like you and I but usually different things can ah basically work together to use that flow of consciousness. So. It's really, a. 30:43.30 mikebledsoe Yeah Youtube Google Facebook Instagram yeah. 30:48.56 Max Shank Oh my god Youtube is such a home run. That's like the most insane I'm so hot on Youtube as a user and as a creator because like the videos I've put up five plus years ago are still getting lots of views and those views a small. 31:01.50 mikebledsoe Yeah, yeah. 31:07.84 Max Shank Percentage converts into people who buy something from me and they're just there they're they're there like I don't even have to pay to have those things there like speaking of you don't need ah money to make money. Of course it's better to have more. It's easier to make money when you have a lot. 31:14.20 mikebledsoe Yeah, yeah, um. 31:25.63 Max Shank Like that's always been the case you know so. 31:26.60 mikebledsoe Yeah I want to go back to that the Amazon you're talking about people don't want things never want anything slower um in ah Alex hormose's hundred million dollar offers book which is one of the best books on offers I've ever read. Um, if if you're a coach. It's probably the. Like it. It very fits our industry but he talks about getting the 2 things that make something more valuable is speed and effort so less effort faster. An example that he uses in the book is. Why will so why would somebody spend $20000 on liposuction but have a hard time spending a couple thousand dollars on a trainer even though like it's obvious to everyone listening why you wouldn't want to get liposuction. But why can they charge that amount of money and there's. 32:20.79 Max Shank The speed and the ease. 32:22.67 mikebledsoe No, yeah, there's no um, shortage of people getting their fat rearranged by a surgeon. So. 32:31.97 Max Shank Well, it's like a different value system for that individual right? So they think their time is valuable. They don't think that um the cost of having their body sliced open is too high right. 32:47.11 mikebledsoe Yeah, yeah. 32:50.25 Max Shank And they think and they believe the cost of exercising for a long time is is too high So simple cost right? It's simple cost benefit and when we talk about cost um calories in time are almost synonymous right? because without calories you're dead. 32:54.63 mikebledsoe It's too expensive. 33:07.83 Max Shank But you could also think of time as the resource and actually it's a little more practical to think of it that way like how many hours per day you can invest you have a fixed amount Yada Yada and then you have dollars and as far as. Investing is concerned mean your your stuff and your time is basically all you got right. 33:31.11 mikebledsoe Yeah, so two things I've been thinking about in regard to offers recently I've been asking myself None questions. The none question entered my mind. Um as I was talking to a buddy who's in the cosmetics industry and he found. He found a product that if he walked into a room 80% of the women wanted his product and that got me thinking I go wow what is a product that if I walked in a room more than half the room would want it. So. 34:07.38 Max Shank Just start hanging out with me. But um. 34:10.20 mikebledsoe That's right, that's right? Ah, but there's there are certain products. Um you know, 80% of the people are using toilet paper 80% of the people drink water you know at least um at least 80% but yeah so like ah. 34:18.16 Max Shank Wait only 80% do the ah I mean I guess some people use the wet wipes but like in America at least a lot of people wipe their ass with their hands. 34:29.50 mikebledsoe Learnings We got bad days and wet wet wipes. Yeah in hand. Yeah yeah. 34:35.80 Max Shank Also that yeah and hand for talking global. It's better to just focus on North America or America for the sake of these conversations right? That's where our audience is. 34:47.50 mikebledsoe Most of them I think we had someone listening from Chad someone from Chad was listening yesterday I'll show you the stats. Yeah so Chad um the ah so I was thinking about like what is what is it that. 34:51.27 Max Shank I apologize to all of our audience in Sudan fucking from from Chad no way that's funny. Ah. 35:06.49 mikebledsoe That almost everybody wants to have and then and then a couple months ago I started asking myself the question of like how would I add a zero to every time I sell something how would I how do I make it 10 times more valuable. So. 35:22.97 Max Shank Oh. 35:24.76 mikebledsoe Some people may hear that and go how do I make it 10 times more expensive. No 10 times more valuable at least so valuable that someone had to have it so those are like 2 thought experiments I've had around offers I think that you know. 35:38.73 Max Shank You have. 35:42.60 mikebledsoe 1 is what's the total addressable market. So how many people out there want or need yours and also looking at how many people are offering the same exact thing that also impacts the total addressable market. So if you can offer something that's truly unique. Your marketing doesn't even have to be that good that truly solves a problem. 35:51.67 Max Shank 9 36:01.49 mikebledsoe And ah, a lot of people want it. It doesn't have to be that great and then um I think it's also much easier to create good marketing when you have that really special unique offer. Um and then also the thought experiment. I really like to do is the the 10 x how do I make this None times more valuable. What would what would that product or service look like for those people or what are those people spending that much money on. So if I go okay, what do people spend none on the majority of the market that spends that kind of money. 36:31.00 Max Shank Oh. 36:39.37 mikebledsoe Usually a home wine. Yeah so ah anyways, and then and then the other experiment too is what would your? what would your offer look like if it was a None of the price. 36:40.35 Max Shank Wine. 36:47.13 Max Shank Individual bottles. 36:55.47 Max Shank Yeah I like the decimal. The decimal imagination is pretty good across the board for any of those like can we get it 10 times faster to them. Can we get the results 10 times faster can we make the experience last 10 times as long, you know all that. 36:56.65 mikebledsoe What could you deliver. 37:11.80 mikebledsoe Yeah, um, yeah. 37:14.78 Max Shank Is ah it's a clean visualization for some reason it it expands way more than thinking of doubling it I mean of course mathematically. 37:19.44 mikebledsoe Well doubling doesn't work doubling doubling doesn't work because people I believe that people's minds will start gravitating towards working twice as hard. It's It's a lot easier to work twice as hard that if I say. 37:32.10 Max Shank Oh here. 37:38.36 mikebledsoe the the 10 x thinking is a governor on how much work you can do because you can't work 10 times more than you're already working I mean unless you're only working an hour a da hour then then you could shut up max. But then. 37:46.62 Max Shank Yeah I mean I could. 37:54.70 Max Shank Ah, hey this is work is my work for the day. 37:55.57 mikebledsoe But then um, yeah, there you go? Ah so so the 10 x thinking really does force people into a high leverage way of thinking. It's a higher order of thinking. 38:05.42 Max Shank I agree. You also said something that I was just talking about yesterday which is huge is you don't want to identify with suffering I mean you can if you want to but I feel like it is a major inhibitor in the results you get. Because instead of your ah result being proportional to the result itself your your metric is how much you suffered and the ratio of how much you suffered to what you produced and I think that um holds a lot of people in a. 38:38.16 mikebledsoe Um, yeah. 38:44.92 Max Shank Really diminished state because the the value that they were taught either implicitly or explicitly is that suffering is the value. Not the value is the value and hey that's fucked and I'm sorry if that's you ah. But you can change your mind if you want to. 39:06.58 mikebledsoe Ah, you're you're spot on. Yeah there there was a period of time where I didn't yeah. 39:13.72 Max Shank That's what I learned I mean full disclosure. That's what I learned like if you suffer more you're more good and the reality is ah like that's kind of true historically like when we tell stories if a guy suffers a lot. We're like man that Martyr was a real badass. He got. Drawn and quartered for what he believed in or this guy got crucified for what he believed in I mean crazy right? So you don't want to identify with suffering. It's way it's way more It's kind of a ah weird selfish thing. 39:34.23 mikebledsoe Yeah, yeah, yeah, wild. 39:49.29 Max Shank And if you really focus on solving a problem for somebody else. You'll recognize that your suffering is totally irrelevant except for the fact that if you suffer more you'll probably be able to produce less. So so. 40:00.32 mikebledsoe Yeah, the um ah in my in my trainings a lot of times I have students they do a journaling about how about the the collapse distinction of sacrifice and service and. 40:16.62 Max Shank Oh shit. That's a good one I hope you have that written down. It's nice. 1 40:19.67 mikebledsoe Yeah, So there's yeah, there's there's this it happens a lot with people with military Backgrounds Blue Colar Backgrounds I mean such as max and I come come from these types of backgrounds and the idea is that. Sacrifices and service are like intermingled constantly in the language. So as you're getting older because here's the thing we learn definitions of words through context we don't sit Down. We weren't taught each word and sat down and. Go Oh Let's look at the dictionary so we learn everything through context and so unconsciously a lot of us when when people hear about service their mind automatically translate that to be associated with sacrifice as Well. And so. 41:12.82 Max Shank Get right. 41:14.92 mikebledsoe What ends up happening I see this a lot with mothers is if they like they they can't enjoy themselves because the moment they start enjoying themselves. They're not being a good mom. Yeah, exactly exactly So this. 41:18.34 Max Shank Oh yeah, the Sufferin mama. 41:27.80 Max Shank They're a bad mom. You're a bad mom. What are you fucking enjoying yourself bad mom. 41:34.74 mikebledsoe This idea So I have everyone journal out you know, ah the definition of each go look it up just go look it out and write it down now. Can you have service without sacrifice. Can you have sacrifice without service. Yes, on both. So. 41:40.86 Max Shank M. 41:50.24 Max Shank Depends on how you define sacrifice 1 of the definitions I think for sacrifice is just ah like what are you? What are you paying right? I'm sacrificing this in exchange for this. So it really depends on the. 41:53.71 mikebledsoe Um. 41:57.89 mikebledsoe Yeah, well my friend Jesse just yeah well Jesse Elder defined the sacrifice is that you the difference between sacrificing and investing is. 42:07.32 Max Shank The definition. So what you said is right? You just have to have it there. 42:16.53 mikebledsoe A lot of times people use the word sacrifice when they're talking about giving up something now for something greater later and that's yeah and that's technically an investment. Not a sacrifice sacrifice is when you give up something for a lesser value. So that's. 42:21.74 Max Shank Like in a chess game when you do a sacrifice for a gambit. 42:35.33 mikebledsoe That's a distinction that he's created that I that I find to be really useful that may not necessarily be true, but it's a really useful way to think possible. What. 42:39.58 Max Shank Um, you know I don't even know if it's possible to sacrifice something for a lesser value because in that moment you are making a value estimation. On what you're going to get out of this behavior. So I think you are always ah basically gambling. Um, it kind of is similar to yeah I think I mean people always do what they think is going to get them. 43:04.90 mikebledsoe Ah, sometimes people know that they're gonna I don't know it's hard to say I. Well, let's get out. 43:15.94 Max Shank The the most for the least if we want it if we want to simplify it down people want the most for the least and sometimes what they give up is not worth as much as what they got is like my friend Rob says is the fucking you're getting worth the fucking. You're getting. 43:32.52 mikebledsoe Um, or going like this. Yeah. 43:33.84 Max Shank Ah, ah what you made me think of you. What me? what you made me think of though um was why I think ah tolerance is the worst thing in the world I think being able to I think. 43:48.85 mikebledsoe Dude you live in California you're supposed to be tolerant of everything everybody all the time you you should have a flat flat set of values. Everything should be the same value all the time. 43:52.76 Max Shank No okay so go go ahead and lump lump me in lump me in with tens of millions of people in a sweeping generalization because I'm such a normal such ah because I'm such a normal fucking dude in the None place right. 44:02.66 mikebledsoe I Just did I. 44:11.11 mikebledsoe Ah. 44:12.38 Max Shank Jesus fucking Christ so being able to tolerate physical forces. That's good. That's athletic, right? But when people tolerate something. Ah let's say psychologically or relationship. Wise it's ah it's one of the worst things you can do because you're not what you should do is you should reject it or you should accept it and I think people make the mistake of they tolerate. Which is like they're being wounded constantly and they build this resentment from this little barbed wound so you should either accept it fully or reject it but you should never tolerate never tolerate behavior you don't want accept it. Let it go or reject that shit. 45:02.91 mikebledsoe Ooh. 45:07.80 Max Shank Don't fucking tolerate. It's the work tolerant. You heard it here first. Tolerance is the worst thing for a relationship. That's what's up. 45:13.70 mikebledsoe I Love it I Love it. You're right I like the acceptance or reject it. Tolerance tolerance is like I don't want to make a choice I don't want to. It's a lack of responsibility in the context your. 45:25.60 Max Shank Um, yeah, no, it's even worse. It is a choice. It is a choice I'm gonna I'm gonna watch I'm gonna watch this thing that a person does and I'm not gonna like it and I'm gonna Harbor resentment because of it. 45:32.42 mikebledsoe Well, every non-choice is a choice. 45:45.00 Max Shank And it's going to feel like and it's going to feel like a perpetual cost is's going to feel like ah, a perpetual suffering. It's going to feel like a sacrifice. That's what made me think of it is like you're you're you're now in a psychological energetic debt because you are tolerating instead of accepting. 45:51.37 mikebledsoe Ah. 46:02.80 mikebledsoe Yeah, yeah. 46:04.66 Max Shank And it's like that French phrase to know all is to forgive all like you know full acceptance is going to allow that energy to flow full rejection is going to allow you to flow your energy elsewhere but Tolerance is just this like parasitic energy leakage where nobody's winning. Out of that Deal. Tolerance sucks. 46:24.55 mikebledsoe I Really I Really like that perspective. That's that's brand new for me I'm gonna write some things down. But I think that's just gonna be the title of the show is tolerant sucks. 46:41.64 Max Shank I knew I stumbled onto something good here. This is a new thing for me too. It's when within the last week some headline shit. Yeah. 46:42.95 mikebledsoe Yeah, some headline shit. Oh yeah, yeah, what did you? What did you? What caused you to stumble across this one. What we got you thinking on this. Do you remember you might be like me, you just wake up and you're like ah. 46:55.54 Max Shank So my my my special lit I mean I'm kind of like Richard Feynman in that sense where like I just get a kick out of thinking about things I like to dance around with sticks and ropes and clubs and swords and that kind of shit. But. 47:06.10 mikebledsoe Ah. 47:14.72 Max Shank I also get a real kick out of just sitting in a big comfy chair and thinking about shit you know, but this time ah I was talking with my special lady friend. None of her friends. Ah, just recently broke up with her boyfriend right? And so. She went to go console this friend. She told me a little bit about what's going on nothing like no grizzly details or anything like that just in um, you know generalities. How do you interact and relate to another person and. You realize that it's ah it's rarely something like all at once that sends it to hell there is a straw that breaks the Camel's back but there's always something in the background that is being tolerated. That's the problem is like something has been tolerated instead of accepted or rejected. Accepted boom floodgates are open rejected boom the gates are closed and so as far as like ascribing fault to None party or the other like the the alleged offender or the one who's just quietly suffering those offenses. It's like. You got to take away that resentful tolerance and accept everything whole heart as it is or you got to reject it a little bit more forcefully and the longer those boundaries get ah, blurred and fuzzy and. You move your boundaries in and you feel resentment because now you're not really comfortable because your boundaries aren't where you'd like them to be um, it. It just seems so clear to me now even looking back at all my past relationships and I've never felt better about that. Personally because you just learn something from everybody and you appreciate the time for what it was and it's it's very easy to become ah resentful and I think that's ah all because of tolerance instead of acceptance or rejection. 49:21.30 mikebledsoe Love it. Love it. Thank you for that one all right? What's have do with ah fishing poles. Yep. 49:24.63 Max Shank And yeah, man, Thank you, You want to know so people often ah resent their circumstances and they tolerate their circumstances but they don't fully accept them either. And that's like having a big chip on your shoulder. Ah and and you're stuck in this ideology rather than just accepting where where you are here and now and realizing that what you have is here and now and whatever you have. That's what the fuck you have. And if you're like but that other guy has more. It's like Okay, yeah, yeah, he does so like a thousand years ago. The guy who had. 50:08.62 mikebledsoe What are you gonna do about it anytime anyone complains about something I ask them? What are you gonna do about it and a lot of time that throws people off. 50:19.83 Max Shank Um, well look. You should either be ah like asking for help or offering help Really if you're not sure what to do like ask for help or offer help You're not going to get anywhere. 50:29.63 mikebledsoe Yeah. 50:35.87 Max Shank By complaining unless you go into politics then you can get a tremendous amount you can actually get more power and money than anyone else in the world If you just come That's professional level complaining. 50:43.67 mikebledsoe Could you imagine if if ah could you imagine? ah like ah a Ceo going out in the world and complaining for his marketing just going out there and complaining about shit. 50:59.28 Max Shank Ah, Amazing. You can only complain as part of your marketing If. You're complaining about the state of the market I Can't believe how horrible this market is. That's why I came in here to change the game with my new and improved version of what this market is lacking like there's a., There's ah, there's a place for it for sure. But yeah I I think ah, you don't want to tolerate your situation you fucking accept it or you reject it and you come up with a new one. But I think I Really think Tolerance is like ah a really bad value. Ah, in the sense that we're talking about and in the sense of physical forces. It's one of the best ever means you can tolerate a huge amount of force without ah deform ah plastic deformation right? without breaking or deforming. So That's that's a good thing physically and then energetically acceptance not tolerance but acceptance so I think that applies to where people are in their lives. Professionally I think Also I think a lot about. A lot of acceptance is about seeing things for what they truly are and when it comes to putting an offer together. It's like it's great if you like something but it doesn't mean that other people have to like it and the same thing is true for like a solution that worked for you. It. It may not be the solution that everybody else wants and I think that's ah, that's how a lot of people get sucked into some sort of weird fanaticism or zealotry I'm trying to think of a less fancy word but they get they get really hyper about something. Because it really worked well for them and then they start basically using a hammer to bash down every screw that they find because they don't know the difference in what is being presented in that other person versus what happened to them. They're like oh my God I did hamstring curls and it cured my life. Everyone's doing hamstring curls and I've I've attended maybe 50 weekend seminars in my life. No. Well I mean as a student I've taught like 200 but I I would ah I would notice it in myself. I'd go to a seminar I'd come back and I would just be like parroting that shit I couldn't help it you know and as I started teaching more seminars I made more and more of a point to remind people to not just like brain dump. 53:31.78 mikebledsoe Yeah. 53:46.65 Max Shank Everything I told them on their new clients and think that you know it's a 1 ne-size fits all approach to everything. 53:50.90 mikebledsoe Yeah, yeah, yeah I had a ah talk with a guy the other day where I told him just that in his marketing is focus on the benefits. Not the features. He had all these features it was revolutionary for him. 54:05.10 Max Shank Revolutionary Revolutionary Revolutionary The features just need to be a bullet point to justify the price I think unless it's part of the story. 54:08.55 mikebledsoe But it's well this is this is the problem. Well None problem is people are focused on the people people know the features and they think that if I they tell other people the features they're going to get the value of it but they need to hear the benefit they're going to get from the features. But the other thing is is going back to being in touch with reality I'm not sure. There's you know I think there's some coaches out there that are telling other coaches that you know they can make a million dollars you know following their their bliss type of thing. But. 54:45.90 Max Shank Some of them some of them. Yeah. 54:47.64 mikebledsoe Some of them some of them can and I think part of it is like some of them did and then they turn around tell people do the same thing but that doesn't always work. So for instance, yeah. 54:56.64 Max Shank It's like multi-level marketing. It's like multi-level marketing like 90% of the people. Ah, it didn't have what it takes in the none place and did nothing with it and then a small percentage are like fucking rock stars and they're like. What is this an electric dildo some fancy antioxidant berry juice I'll sell None of them this month I'm on it. You know what? I mean it doesn't it doesn't matter even what it is. There's just that crew that will always do well. But. 55:14.20 mikebledsoe Yeah, yeah, yeah, yeah, absolutely. But I get for instance I'll get a I'll get a coach as I'm like um I'm like okay, what are your goals. Oh I want to be able to make x amount of dollars. I was like okay your business needs to make this amount if you want to take this amount home and there and then it's kind of like a oh shit and I'm like okay who's your who's your client like what type people are you serving is like well mma fighters in their early twenty s trying to go pro. 55:32.25 Max Shank Well. 55:50.50 mikebledsoe And I go Well do those guys have money. Do they have and and do they valueate? Yeah I mean and well I think most guys trying to go pro and mate don't have money I I. 55:54.28 Max Shank Do they want this I mean a lot of them may have money but do they want it. 56:05.48 Max Shank My experience is the same I used to want to train those guys like my gym at the very beginning because I was into all that shit I was like a fucking retarded testosterone out 21 year old when I started my gym I was I was fighting in the cage. 56:08.46 mikebledsoe Okay, yeah. 56:25.37 Max Shank Was like I am a tough motherfucker and I'm gonna fill this gym full of guys just like me and you know what those guys didn't pay a God damn thing those guys suck Those guys are those guys are always about like. 56:30.30 mikebledsoe Yep. 56:39.51 Max Shank Ah, dude I'll tweet you bro and I'm like oh Jesus fucking. It didn't take long for me to head down to the country clubs and swoop up some of the 45 to 65 range there are easier businesses and hard businesses. Let's just say it that way. 56:41.49 mikebledsoe I'm great people. 56:46.79 mikebledsoe Exactly exactly? Yeah, so like what I. 56:59.15 Max Shank There are easier businesses. There are things that people already want and there are things that are a tough sell. 57:01.69 mikebledsoe Yeah, well here here's the thing I I do 2 things for free. So I get.? Yeah yeah I did 2 things I have 2 offers for free that I give people and both of them tap into my expertise that I normally get paid for or at least used to get paid for and I am he ruined it as. 57:11.61 Max Shank I'm excited by whatever these 2 things are going to be by the way. Ah. 57:25.76 Max Shank Is it prostate massage is that one of them. Sorry. 57:31.23 mikebledsoe Um, so I give these things away and I and I love it because I don't charge a dime for it whereas a bunch of other people are trying to figure out how to charge what I'm doing when I'm offering for free and the only reason I can offer it for free is because I have. Paying customers somewhere else people that actually do have money. 57:50.81 Max Shank Oh shit, he's flexing on y'all right now I give away better stuff for free may maybe better. You don't always get what you pay for, but it's because you are so confident. 57:57.60 mikebledsoe Well not yeah, probably but like maybe better you don't always get me pay for it. 58:08.12 Max Shank In your ecosystem right? that you have created that once they experience something you've given them for free. You got None of value down the road right? no. 58:15.17 mikebledsoe Well well here's the thing is thinking about like um, well yeah, maybe but actually I don't have a plan for it at all with the 2 things I like I have no plan for either None of these things to ever make money and these are. But types of thing people want to help people who it's charity. That's not really it's not it's not really charity um oh no, what? what? I give away for free is I do a Tuesday night workout for a handful of my buddies at my house. 58:32.25 Max Shank Um, so it's so it's marketing. No fuck you. It's not char you it's marketing a free book is great marketing. 58:48.71 Max Shank Oh that's nice. Yeah, that sounds great. 58:51.82 mikebledsoe Right? And then we grill some meat afterwards and we kick it and they get world-class training. You know most of them never been exposed to like a coach that's been exposed to things I've been exposed to so they're getting their minds blown. They're learning more about their bodies for an hour once a week and. 59:09.18 Max Shank I dig it. 59:10.76 mikebledsoe I and I never care to train pay you know accept money for for physical training. So I do that So I give that away for free and then I give away which I give that to people who don't know that they could get training right? like they don't even know to go get it but because. 59:25.58 Max Shank Right. 59:29.20 mikebledsoe My friends I'm like come over to my house I'll I'll I'll treat you and then on Thursday mornings I have I meet with these guys who are blue collar and these guys could can't afford me for for the types of of advice and. Coaching that I would give but if they can figure out a way to make time out of their day at None a m on Thursdays I meet with them at the park. We kick it for an hour and I just help them with whatever it is. That's going on in their life. Well I just kept on coming across all these guys so like ah it was like I was getting like all these blue collar guys like. 59:59.36 Max Shank No kidding How do you set this one up. 01:00:08.40 mikebledsoe I'd be at a cafe student just couldn't stop talking to me so I was like I Well I guess I'm not supposed to work' going to supposed to talk to this guy. So I talked to this guy I'm like oh you start sharing his problems with me is like I don't know why I all a sudden look like a a target for other people's problems. But then. 01:00:16.86 Max Shank Ah. 01:00:26.97 mikebledsoe I Got a guy that came to saw saw me solar and you know the the conversation turned and he needed some help so I was able to give him some help and then another guy I met ah you know at the at the gym same thing like you know he's he's. Somehow what opens up to me and starts talking and then so I got these guys and I'm like look if you have any of your other friends that you know and some of these guys are dealing. You know they're dealing with some heavy like legal stuff and all sorts of crazy shit and so I'm meeting with them and. For most of them the benefit they get is just understanding that whatever they're experiencing internally other guys are experiencing that same thing internally too. I mean that that by itself is just so healing because most of these guys they screwed up something we Well we all screwed up. 01:01:14.37 Max Shank Ah. Lost Boys their lost boys. 01:01:23.26 mikebledsoe We we all screw up in our life. Yeah, we all screw up in our life At some point right? and then we then we judge our s ourselves for having screwed up and most guys they just clam up and never share that with anybody because they think that their situation is truly unique. 01:01:33.28 Max Shank Often. Talk about suppressing right? I mean who suppresses more than dudes with their feelings. Ah. 01:01:41.70 mikebledsoe Yeah, yeah, So um, so just just the act of getting out and hanging out and talking about it and then realizing that other dudes have the same problems and then and then I'll obviously also offering strategies for dealing with. These things. Yeah, so these are 2 things that I like to I just do for for free that I know other people are trying to charge for and if you're trying to sell coaching to somebody that doesn't have money like I don't have any interest in trying to sell something. 01:02:02.70 Max Shank It's like a feeling of a community. It sounds like. 01:02:18.38 mikebledsoe To the blue collar I'm not gonna go sell coaching to the blue collar community one. They're not really looking for it. Um, and ah because they don't know it exists. They just don't even know it exists. Yeah. 01:02:22.90 Max Shank But now. 01:02:31.73 Max Shank You're talking about using the right bait for the right fish basically and the fact that not everything has to be ah, a monetary exchange because my guess is you get a tremendous amount out of these experiences every week otherwise you would not do them. 01:02:38.25 mikebledsoe Not everything. 01:02:44.47 mikebledsoe I Absolutely so but the only reason I can do them is because I am using the right bait with the right fish somewhere else that feeds me it pays my bills it. 01:02:53.96 Max Shank Exactly you got a crew of guys out on a fleet of boats. They're catching fish you're shooting the breeze with the guy at the diner and if you don't free up your time. Ah, you're always stuck with the pole. 01:03:02.32 mikebledsoe Exactly. 01:03:11.21 Max Shank In the River You don't have a chance to tell other guys about fishing. You don't have a chance to just relax on the beach yourself. Um, yeah, that's a really interesting way to use our resources right? It's like you're using your resources to get something that. 01:03:29.84 mikebledsoe Yeah, well, ah, there's ah this this actually happens in like a lot of the the medicine world like I learned about this from Ashley she's psychotherapist and they have this thing called a sliding scale. So you know they may charge. 01:03:31.12 Max Shank Ah, you can't purchase. 01:03:49.28 mikebledsoe Two hundred bucks, two hundred and fifty three hundred bucks an hour as as a psychotherapist to their clients. But if someone comes in There's a certain number of spots they have allotted that they're allowed to go down in a sliding scalells like you know I'm only in charge you a hundred bucks because I know you can't afford it in this and that and I look at it I go man. Ah, sliding scale is too narrow I want a sliding scale where I'm charging this person $3000 per hour and then I'm giving this person the thing for twenty bucks an hour or five bucks an hour or free ends. 01:04:20.22 Max Shank Well, that just means you're good at drawing a boundary of what you feel comfortable with my my thing is people pay full price. Ah for what I'm doing or they pay nothing and I I I like that I like that idea better. 01:04:31.70 mikebledsoe Yeah, that's that's pretty much I don't I don't do discounts either. You know. 01:04:39.83 Max Shank Because um, when I was when I was coming up when I was just a young book coming up I was ah you know started out coaching people

People Behind the Science Podcast - Stories from Scientists about Science, Life, Research, and Science Careers
652: Exciting Developments in Our Knowledge of Cortical Circuit Formation in the Mammalian Brain - Dr. Franck Polleux

People Behind the Science Podcast - Stories from Scientists about Science, Life, Research, and Science Careers

Play Episode Listen Later Apr 18, 2022 44:32


Dr. Franck Polleux is a Professor of Neuroscience and member of the Zuckerman Mind, Brain, Behavior Institute at Columbia University. Franck's research focuses on understanding the cellular and molecular mechanisms that underlie brain and neuronal development, how neural connectivity may be different in the human brain compared to other mammals, and signaling pathways affected in the early stages of neurodegenerative diseases such as Alzheimer's disease. Outside of his research, Franck is an outdoor enthusiast who enjoys bicycling, playing tennis, and shooting hoops on the basketball court. Franck has two children, and he spends most of his free time with his family riding bikes, going to the theater, and reading together. He completed his undergraduate degree as well as his PhD in Neuroscience at the University of Claude Bernard in Lyon, France. Afterward, he travelled to Johns Hopkins University for his postdoctoral fellowship. Franck served on the faculty at the University of North Carolina, Chapel Hill and The Scripps Research Institute in La Jolla, CA before joining the faculty at Columbia University where he is today. Franck is here with us today to tell us all about his journey through life and science.

Podcasts – Weird Things
WT: Mammalian Asteroid

Podcasts – Weird Things

Play Episode Listen Later Mar 22, 2022


The invasion of Ukraine has affected space! Is yellow really just yellow? Half of a giraffe makes an astral appearance. Got something weird? Email neshcom@gmail.com, subject line “Weird Things.” Picks: Andrew: Twitter lists Justin: Encanto Brian: Eye Wonder Bryce: F1TV Support Weird Things on Patreon Subscribe to the Weird Things podcast on iTunes Podcast RSS […]

Finding Genius Podcast
The Behavior of Sex Chromosomes and the Understanding of the Mammalian Genome with Jennifer A. Marshall Graves

Finding Genius Podcast

Play Episode Listen Later Mar 10, 2022 32:29


Why is the Australian dragon so fascinating? Since they can change gender based on the temperature in the egg, they can offer insight into several aspects of environmental temperature impact, among much else. Press play to learn: How temperature determines the sex The function of epigenetic modifiers How there can be more sex chromosomes than we initially thought possible Jennifer A. Marshall Graves, a Distinguished Professor and Vice-Chancellors Fellow at La Trobe University, speaks about her research on Australian dragons and various other Australian animals' sex determination. Genes are the primary building blocks that determine all of the traits we acquire during gestation. However, for many species, external factors can play a significant role during incubation or gestation in determining the sex of animals like the Australian dragon. Even in mammals, which we previously thought set in sex chromosomes, there can be bizarre differences between humans and the rest of the mammalian range. For example, in platypuses, their sex chromosomes may more closely resemble chickens than humans. Search for Jennifer A. Marshall Graves in your engine of choice for many resources to further explore her work. Episode also available on Apple Podcast: http://apple.co/30PvU9C