Podcasts about dna damage

“Hell is empty, all the devils are here.” – William Shakespeare My question remains, WHY does USA has 92 Nuclear Plants, China 55, Russia 37, Japan 33, South Korea 25, India 22, Ukraine 15, IRAN HAS ONE. Psychopath In Your Life Plutonium: Rocky Flats Anatomy of Disaster. USA has 92 Nuclear, China 55, Russia 37, […] The post Fluoride AND Plutonium = BOTH are EQUALLY Dangerous to Health and CREATE Cancer.  Is this the ROOT cause of Cancer and Sugar is the match that lights the fire?  IRAQ and DNA Damage. appeared first on Psychopath In Your Life.

Dr. Hoffman continues his conversation with Dr. Kieran Murphy, author of “The Essence of Invention: Medicine and the Joy of Creativity,”

In this episode of the Intelligent Medicine podcast, Dr. Ronald Hoffman interviews Professor Kieran Murphy, an interventional neuro radiologist and prolific inventor from Toronto Western Hospital. Dr. Murphy has developed numerous innovative medical devices and filed 60 patents. He shares insights from his book, “The Essence of Invention: Medicine and the Joy of Creativity,” discussing his work on medical innovation, his unique background, and personal experiences that have driven his creative solutions. The conversation covers various topics, including the importance of creativity, the impact of bureaucracy on modern medicine, and groundbreaking innovations like ozone therapy for herniated discs and a radio-protective supplement for medical personnel. Dr. Murphy emphasizes mindfulness and paying attention to phenomena as key components for fostering creativity and innovation in medicine.

Theodora Scarato discusses the potential health risks associated with 5G, cell phones, and cell towers. Learn practical steps to protect yourself and maintain your well-being in a connected world. #5GHealthRisks #ElectromagneticSafety #HealthProtection

Immune explores the immunological diversity in the upper airway, including memory B and T cells and germinal center B cells, and how chronic infection with Plasmodium parasites leads to development of B cell cancers. Hosts: Vincent Racaniello, Cindy Leifer, Steph Langel, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Immune memory diversity in human upper airway (Nature) How Plasmodium infection promotes B cell cancers (Cell) Time stamps by Jolene. Thanks! Music by Tatami. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Originally recorded in 2022, this episode features Dr. Lauren Trepanier from the University of Wisconsin, revealing her groundbreaking research into the link between environmental pollution and dog cancer. Key Topics: Environmental Pollutants and Cancer in Dogs: Dr. Trepanier's research links pollutants such as ozone, benzene, trichloroethylene, and herbicides to cancer in dogs. Lymphoma Study: Ongoing studies on Boxers and Golden Retrievers with lymphoma aim to determine how air pollutants, including ozone and VOCs, may trigger cancer. Bladder Cancer Study: The research also investigates dogs with bladder cancer, focusing on household pollutants like arsenic and acrolein, which are linked to bladder cancer in humans. Human-Dog Connection: Dr. Trepanier explains how dogs' cancer risks from pollutants can also provide insight into potential cancer risks for humans. One Health Initiative: The episode discusses how the One Health initiative encourages collaboration between veterinary and human medical professionals to advance research and treatment. Practical Applications: Dr. Trepanier offers suggestions on how dog owners can mitigate cancer risks, including reducing exposure to VOCs and herbicides. Links and Resources: Dog Cancer Survival Guide by Dr. Demian Dressler and Dr. Susan Ettinger Morris Animal Foundation's Golden Retriever Lifetime Study AKC Canine Health Foundation One Health Alliance Canine Health Foundation Golden Retriever Lifetime Study Boxer Lymphoma Study Recruitment Flier Transitional Cell Carcinoma Study Recruitment Flier Your Voice Matters! If you have a question for our team, or if you want to share your own hopeful dog cancer story, we want to hear from you! Go to https://www.dogcancer.com/ask to submit your question or story, or call our Listener Line at +1 808-868-3200 to leave a question. Related Videos:            A fantastic interview with Dr. Janet Patterson-Kane of Morris Animal Foundation: https://www.youtube.com/watch?v=WEvFhsC_TyY Related Links: Our article on Pollution and other Environmental cancer causes: https://www.dogcancer.com/articles/causes-and-prevention/pollution/ Learn about pharmaceuticals in the drinking water: https://www.dogcancer.com/articles/causes-and-prevention/pharmaceuticals-in-drinking-water/ Our article on Bladder Cancer: https://www.dogcancer.com/articles/types-of-dog-cancer/bladder-cancer-in-dogs-including-transitional-cell-carcinoma/ Our article on Lymphoma: https://www.dogcancer.com/articles/types-of-dog-cancer/lymphoma-in-dogs/ Chapters: 00:00 - Introduction 00:45 - Environmental Toxins and Cancer in Dogs 01:30 - Ozone and Air Pollution's Link to Cancer 03:00 - Fracking and Cancer Risks in Dogs 03:45 - Measuring VOCs in Dogs 05:00 - Chemical Testing in Homes 06:00 - Household Chemicals and Human Studies 07:00 - Bladder Cancer and Household Exposures 09:00 - DNA Damage in Dogs and Owners 10:00 - Bladder Cancer as a Warning Sign 11:30 - How Did My Dog Get Cancer? 12:15 - Practical Steps to Reduce Cancer Risk 13:30 - Chemical Damage After Diagnosis 14:00 - Environmental Concerns from the Dog Cancer Survival Guide 15:15 - Dr. Trepanier's Background and Expertise 16:30 - Research and Time for Discoveries 17:30 - One Health Initiative Explained 19:00 - Veterinarians as Key Researchers in Cancer 20:30 - Recruiting Dogs for Cancer Studies 22:00 - Collaboration with the Golden Retriever Lifetime Study 24:00 - The Importance of Reaching Diverse Communities 26:00 - How Listeners Can Get Involved 28:00 - Generosity of Dog Lovers 29:30 - Dr. Trepanier's Personal Connection Dog Cancer Story 30:00 - Outro and Resources Get to know Dr. Lauren Trepanier: https://www.dogcancer.com/people/lauren-trepanier-dvm-phd-dacvcp-dacvim-saim/ For more details, articles, podcast episodes, and quality education go to the episode page: https://www.dogcancer.com/podcast/ Learn more about your ad choices. Visit megaphone.fm/adchoices

Oren Gilad, President and CEO of Aprea Therapeutics, focused on the DNA damage response pathway, specifically targeting the ATR protein. ATR is a master regulator of DNA replication and is hyperactive in cancer cells, making it a potential Achilles heel for cancer therapy. By inhibiting ATR, cancer cells can be selectively targeted, while normal cells can tolerate lower levels of ATR activity. Synthetic lethality is applied when two genetic mutations are combined, leading to cell death, specifically in cancer cells. Aprea is conducting clinical trials for their targeted treatments, focusing on solid tumors with defined genetic mutations. Oren explains, "DDR, the DNA damage response pathway, is the broader terminology for the regulation of DNA synthesis. In order for cancer to grow, cells have to duplicate. In order for them to duplicate, they have to replicate their DNA. So what happens is that cancer cells get into this DNA replication phase very early and prematurely, causing a single-strand DNA to be exposed which then activates the ATR pathway, where in normal cells, this pathway is very tightly regulated. The normal cell is not going to enter this phase and start DNA replication before the environment is ready because it's a very fragile phase of the cell cycle." "Double-strand DNA is a very stable molecule. It is found in mummies, it survives heat, and it survives freezing. When a double-strand DNA molecule is opened, the exposed single-strand DNA can easily break. That's where ATR comes into play, it protects and responds to single-strand formation. A cancer cell is hyper-sensitive to ATR inhibition, which we identify as the Achilles heel of cancer. Our work showed that normal cells can live with a reduced level of the ATR activity, so it makes it a good target for cancer therapy." #ApreaTherapeutics #CancerTreatment #TargetedTherapy #Oncology #Cancer #SyntheticLethality #DNADamageResponsePathway aprea.com Download the transcript here

Oren Gilad, President and CEO of Aprea Therapeutics, focused on the DNA damage response pathway, specifically targeting the ATR protein. ATR is a master regulator of DNA replication and is hyperactive in cancer cells, making it a potential Achilles heel for cancer therapy. By inhibiting ATR, cancer cells can be selectively targeted, while normal cells can tolerate lower levels of ATR activity. Synthetic lethality is applied when two genetic mutations are combined, leading to cell death, specifically in cancer cells. Aprea is conducting clinical trials for their targeted treatments, focusing on solid tumors with defined genetic mutations. Oren explains, "DDR, the DNA damage response pathway, is the broader terminology for the regulation of DNA synthesis. In order for cancer to grow, cells have to duplicate. In order for them to duplicate, they have to replicate their DNA. So what happens is that cancer cells get into this DNA replication phase very early and prematurely, causing a single-strand DNA to be exposed which then activates the ATR pathway, where in normal cells, this pathway is very tightly regulated. The normal cell is not going to enter this phase and start DNA replication before the environment is ready because it's a very fragile phase of the cell cycle." "Double-strand DNA is a very stable molecule. It is found in mummies, it survives heat, and it survives freezing. When a double-strand DNA molecule is opened, the exposed single-strand DNA can easily break. That's where ATR comes into play, it protects and responds to single-strand formation. A cancer cell is hyper-sensitive to ATR inhibition, which we identify as the Achilles heel of cancer. Our work showed that normal cells can live with a reduced level of the ATR activity, so it makes it a good target for cancer therapy." #ApreaTherapeutics #CancerTreatment #TargetedTherapy #Oncology #Cancer #SyntheticLethality #DNADamageResponsePathway aprea.com Listen to the podcast here

Subscribe to our channel: https://www.youtube.com/@optispan Check out the Gurkar lab: http://agresearchlab.com/ In May 2024, Matt delivered a talk at the 2024 Glenn AFAR Grantee Conference in Santa Barbara, California and met with several people doing interesting work in the longevity field. One of these was Aditi Gurkar, an assistant professor in the University of Pittsburgh's Aging Institute, Division of Geriatric Medicine whose lab focuses on the downstream effects of DNA damage on aging. Prior to setting up her lab at the University of Pittsburgh, Aditi conducted research on the impact of DNA damage on aging at Scripps Research. She also completed postdoctoral training at Massachusetts General Hospital/Harvard Medical School and the Broad Institute of MIT and Harvard, where she focused on the tumor suppressor p53 as well as on autophagy regulation. Aditi received a PhD and a B.S. from the Boston University School of Medicine and Florida International University in Miami respectively. Matt and Aditi spend much of this episode chatting about senescent cells: how Aditi developed a focus on cellular senescence and found its relevance to aging, potential therapeutic benefits of senescent cell clearance, and the much-debated question of how to define a senescent cell. They also discuss the importance of "zooming out" from narrow areas of focus in the geroscience field to find new solutions and of breaking your own models on your way to productive new directions in science. Producers: Tara Mei, Nicholas Arapis Video Editor: Jacob Keliikoa DISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices. More places to find us: Twitter: https://twitter.com/optispanpodcast Twitter: https://twitter.com/optispan Twitter: https://twitter.com/mkaeberlein Linkedin: https://www.linkedin.com/company/optispan https://www.optispan.life/ Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it. On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!

BUFFALO, NY- June 26, 2024 – A new research perspective was published in Oncotarget's Volume 15 on June 20, 2024, entitled, “Starving cancer cells to enhance DNA damage and immunotherapy response.” Prostate cancer (PCa) poses significant challenges in treatment, particularly when it progresses to a metastatic, castrate-resistant state. Conventional therapies, including chemotherapy, radiotherapy, and hormonal treatments, often fail due to toxicities, off-target effects, and acquired resistance. In this new research perspective, researchers Aashirwad Shahi and Dawit Kidane from Howard University define an alternative therapeutic strategy focusing on the metabolic vulnerabilities of PCa cells, specifically their reliance on non-essential amino acids such as cysteine. “In this prospective, we will rise the driving questions and potential possibilities how amino acid depletion induced oxidative stress associated DNA damage exploited for DNA repair targeted and immune checkpoint blockade therapy [...].” Using an engineered enzyme cyst(e)inase to deplete the cysteine/cystine can induce oxidative stress and DNA damage in cancer cells. This depletion elevates reactive oxygen species (ROS) levels, disrupts glutathione synthesis, and enhances DNA damage, leading to cancer cell death. The combinatorial use of cyst(e)inase with agents targeting antioxidant defenses, such as thioredoxins, further amplifies ROS accumulation and cytotoxicity in PCa cells. “Overall, this perspective provides a compressive overview of the previous work on manipulating amino acid metabolism and redox balance modulate the efficacy of DNA repair-targeted and immune checkpoint blockade therapies in prostate cancer.” DOI - https://doi.org/10.18632/oncotarget.28595 Correspondence to - Dawit Kidane - dawit.kidane-mulat@howard.edu Video short - https://www.youtube.com/watch?v=Zrj24o_-b50 Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28595 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, amino acid depletion, DNA damage, DNA repair, Immunotherapy, tumor immunity About Oncotarget Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. Oncotarget is indexed and archived by PubMed/Medline, PubMed Central, Scopus, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science). To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957

What can worms teach us about carcinogen exposure or chemotherapy? Sophia Tintori, postdoctoral associate in the biology department at New York University, heads to Chornobyl to find out. Sophia Tintori is a postdoctoral associate in the Biology Department at New York University. She was trained in developmental biology, cell biology, and genetics at Brown University […]

Hugues de ThéCollège de France - Année 2023-2024Oncologie cellulaire et moléculaireColloque - Explorer la réponse thérapeutique in vivo : Targeting the DNA Damage Response and Immune Response Interplay: Novel Therapeutic OpportunitiesIntervenant(s)Sophie Postel-VinayInstitut Gustave Roussy et University College of London

Hugues de ThéCollège de France - Année 2023-2024Oncologie cellulaire et moléculaireColloque - Explorer la réponse thérapeutique in vivo : Sources of Endogenous DNA Damage and Mutations in Blood – It's Not Just Water and OxygenIntervenant(s)Ketan PatelChief Scientist CRUK Director of the Weatherall Institute of Molecular Medicine Oxford University

Hugues de ThéCollège de France - Année 2023-2024Oncologie cellulaire et moléculaireColloque - Explorer la réponse thérapeutique in vivo : Cellular Responses to DNA Damage: From Stalled Forks to Inflammation and BeyondIntervenant(s)Philippe PaseroInstitut de Génétique Humaine, CNRS et université de Montpellier

The Wyrd Mountain Gals Show "Breakfast Candy  Part 2" Episode Airs Sunday, 5-19-24     7pm Episode Link Here: https://www.podbean.com/eas/pb-jb2xp-1617cc0 Alicia thinks this is the "20 Confessionss" episode.     Byron is taking her vitamins on this sunny/breezy morning.  Alicia just figured out that her computer has a touch screen (duh!).    "The bloom is off the rose":  The person, object, or situation identified in the context has lost its novelty, freshness, appeal, or acceptability "When the frost is on the punkin..":  The saying comes from a 19th century poem written by James Whitcomb Riley titled “When the Frost is on the Pumpkin”, which referred to when it was time to reap the autumn harvest Darmok (episode): https://memory-alpha.fandom.com/wiki/Darmok_(episode) Long vax:  https://www.medpagetoday.com/neur.../generalneurology/107644 Effects of COVID-19 Disease on DNA Damage, Oxidative Stress and Immune Responses:  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145820/ Fantastic Fungi:  https://fantasticfungi.com/     #WyrdMountainGals #ByronBallard #Appalachia #DigitalWitchery

The Wyrd Mountain Gals Show "Breakfast Candy" Episode Airs Sunday, 5-12-24     7pm Episode Link Here:  https://www.podbean.com/eas/pb-gqs3a-160d79c Byron is taking her vitamins on this sunny/breezy morning.  Alicia just figured out that her computer has a touch screen (duh!).   "The bloom is off the rose":  The person, object, or situation identified in the context has lost its novelty, freshness, appeal, or acceptability "When the frost is on the punkin..":  The saying comes from a 19th century poem written by James Whitcomb Riley titled “When the Frost is on the Pumpkin”, which referred to when it was time to reap the autumn harvest Darmok (episode): https://memory-alpha.fandom.com/wiki/Darmok_(episode) Long vax:  https://www.medpagetoday.com/neurology/generalneurology/107644 Effects of COVID-19 Disease on DNA Damage, Oxidative Stress and Immune Responses:  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145820/ Fantastic Fungi:  https://fantasticfungi.com/       #WyrdMountainGals #ByronBallard #Appalachia #DigitalWitchery

In this episode of Longevity by Design, host Dr. Gil Blander is joined by Dr. Morten Scheibye-Knudsen, a leading figure in aging research. Dr. Scheibye-Knudsen discusses his groundbreaking research on the role of DNA damage in the aging process and its implications for chronic diseases, aging research, and longevity medicine. The goal of his work is "to discover interventions leading to healthier, happier, and more productive lives."Dr. Scheibye-Knudsen's work is on understanding normal and premature aging, with a focus on the pivotal role of DNA damage in the aging process and interventions for healthier aging. By combining computational methods with laboratory experiments, his team explores innovative strategies to target DNA and counteract aging processes. This conversation illuminates the intricate relationship between DNA damage, aging, and chronic diseases. Dr. Scheibye-Knudsen also discusses the impact of lifestyle (diet, exercise, sleep, social factors) on aging. He goes on to describe his work using data-driven approaches to better understand aging and developing interventions, including identifying novel targets and drugs, for healthier aging. Additionally, he explains what longevity medicine is and the importance of educating clinicians and politicians on this topic to translate research on aging into healthcare and improve people's healthspan and lifespan. Dr. Scheibye-Knudsen's dedication to unraveling the mysteries of aging is advancing scientific knowledge, which has tangible benefits for global health and longevity.Episode timestampsIntroduction: 00:00-03:06What led Dr. Morten Scheibye-Knudsen to become a scientist?: 03:07-04:37Could please give us an overview of the research you are doing?: 04:38-05:54What is DNA damage, and what causes it?: 05:55-07:54What do we know about the influence of DNA damage on aging and age-related diseases?: 07:55-09:41Can DNA damage be repaired? 09:42-14:14What questions are your research group asking to better understand DNA damage and repair and their effects on aging?: 14:15-16:22What is NAD, and why is it relevant to aging and age-related diseases?: 16:23-19:56What are the benefits and risks of NR and NMN supplements in humans?: 19:57-24:50What is a ketogenic diet? What are the effects of a ketogenic diet or ketones on DNA damage or repair and aging?: 24:51-31:08What is the effect of a ketogenic diet on cancer?: 31:09-32:29What is the Aging Research and Drug Discovery (ARDD) conference and its mission?: 32:30-40:43What are the most prevalent features of aging?: 40:44-47:54Are there differences in aging between females and males?: 47:55-50:21Are there differences in tissue aging trajectories?: 50:22-54:01Identifying compounds that target aging: 54:02-56:16Can nuclear morphology predict cellular senescence and cancer?: 56:17-01:04:04What is longevity medicine, and why is it so important for physicians?: 01:04:05-01:07:25What pharmaceutical drugs are the most promising for targeting aging to extend human healthspan and lifespan?: 01:07:26-01:12:00How important are lifestyle factors such as nutrition, physical activity and exercise, sleep, and social engagement and connections for human healthspan and lifespan?: 01:12:01-01:16:39Dr. Morten Scheibye-Knudsen's top tip for health: 01:16:40-01:18:22

In this episode, we are sharing highlights from our webinar, ‘Mental Health and Wellbeing' with Michelle Overton. Michelle is a qualified counsellor and Mental Health First Aid Instructor Trainer. She discusses the impact of life's challenges on your mental health, coping mechanisms for stress and her top self-care tips. You can watch the original webinar here. Keep reading for the key episode takeaways. Topics and Timestamps: 01:03 Michelle shares her own mental health journey. 06:05 How does mental health shape your self-esteem and confidence? 08:27 The impact of life's challenges on your mental wellbeing. 11:00 Stress and how it can affect your DNA. 13:53 Shifting from unhealthy to healthy coping mechanisms. 19:14 Michelle's top self-care tips for improving your mental health. 24:02 The power of listening. 25:46 How you can find ways to improve sleep and mindful practices. Selected Key Takeaways: Mental health impacts many aspects of life. 07:01 “Confidence can be gauged in new situations [by] learning new skills [or] it could be in a workplace. Self-esteem is how you value yourself on the inside. Our mental health will govern how we feel, how we think, how we behave and how we manage change. It will [also] govern how we make, sustain and end relationships.” Stress can impact our physical health.   10:35 “After you've been experiencing stress for more than two weeks, your body will start to kick out hormones. Your double helix is your DNA and at the bottom of it, you've got the bottom of your shoelace strings that keep it together at the bottom, when the hormones are being kicked out from the stress, what happens is the shoe lay strings get corroded, and it comes undone. And this is when we start to get rogue DNA going around. And that's why it's been linked to being carcinogenic." Find what works for you and your mental health.   25:52 “It's finding what's right for you. I find talking has been a really helpful space for me, whether that's in therapy, or whether it's support services. Making sure that you're hydrated as well. Water can be a very simple thing that can really help instantly.” Want to learn more about living a full and happy life with multiple sclerosis? Sign up to our newsletter to hear our latest tips. More info and links: Watch the original webinar 5 Ways to Wellbeing from Mind Follow Michelle on social media on LinkedIn or Instagram Read Michelle's bio Study: Effects on DNA Damage and/or Repair Processes as Biological Mechanisms Linking Psychological Stress to Cancer Risk New to Overcoming MS? Visit our introductory page  Join a Circle and connect with others following Overcoming MS on the Live Well Hub Visit the Overcoming MS website Follow us on social media: Facebook Instagram YouTube Pinterest Don't miss out:  Subscribe to this podcast and never miss an episode. Listen to our archive of Living Well with MS episodes here. If you like Living Well with MS, please leave a 5-star review. Feel free to share your comments and suggestions for future guests and episode topics by emailing podcast@overcomingms.org. Make sure you sign up to our newsletter to hear our latest tips and news about living a full and happy life with MS. Support us:  If you enjoy this podcast and want to support the ongoing work of Overcoming MS, we would really appreciate it if you could leave a donation here. Every donation, however small, helps us to share the podcast with more people on how to live well with MS.

DNA Damage to the Human Race, Cancer Rates, Blood Clots, Myocarditis etc. Dr. Ryan Cole, Ed Dowd, Dr. Peter McCullough Overwhelming Evidence the Jab Poisoned the World The Ben Armstrong Show  Jan 16 2024   Other Episodes Top Experts prove beyond any doubt the jab is not safe for human use. DNA damage to the human race is a major concern as well. Dr. Peter McCullough Clip Ed Dowd Clip Dr. Ryan Cole. Blood Clotting. Amyloid protein Clots. Video Sources: 1. Bannon's War Room – Rep. Marjorie Taylor Greene Leads a Hearing on Injuries Caused By COVID-19 Vaccines: Part II 2. YEN VY CHANNEL – Tucker Carlson Tonight 1/15/24 | Tucker Carlson January 15, 2024   For all of Ben Armstrong's shows visit- https://thenewamerican.com/author/barmstrong/     Cancer Rates Are SOARING — WHY?! Steve Deace Show  Jan 18 2024   Other Episodes Steve discusses the American Cancer Society's cancer projections for 2024 and says there's only one explanation.

TODAY ON THE ROBERT SCOTT BELL SHOW: Medical Freedom resolutions, 70% Healthy Americans, Glyphosate DNA damage, Vibrating weight loss pill, Detox Dialogs - Dry Brushing, Militarys mandate push-back, Soil microbiome, Silver Aloe Protocol, Electrocultre, Airplane travel tips, Homeopathic Hits - Symphytum and MORE! http://www.robertscottbell.com/natural-remedies/medical-freedom-resolutions-70-healthy-americans-glyphosate-dna-damage-vibrating-weight-loss-pill-detox-dialogs-dry-brushing-militarys-mandate-push-back-soil-microbiome-silver-aloe-protocol/

BUFFALO, NY- December 19, 2023 – A new #research paper was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 23, entitled, “Sirtuin 6 activation rescues the age-related decline in DNA damage repair in primary human chondrocytes.” While advanced age is widely recognized as the greatest risk factor for osteoarthritis (OA), the biological mechanisms behind this connection remain unclear. Previous work has demonstrated that chondrocytes from older cadaveric donors have elevated levels of DNA damage as compared to chondrocytes from younger donors. In this new study, researchers Michaela E. Copp, Jacqueline Shine, Hannon L. Brown, Kirti R. Nimmala, Oliver B. Hansen, Susan Chubinskaya, John A. Collins, Richard F. Loeser, and Brian O. Diekman from University of North Carolina at Chapel Hill, North Carolina State University, Rush University Medical Center, and Thomas Jefferson University aimed to determine whether a decline in DNA repair efficiency is one explanation for the accumulation of DNA damage with age, and to quantify the improvement in repair with activation of Sirtuin 6 (SIRT6). “In this study, we use irradiation as an acute model of DNA damage to bring the level of damage to equivalent levels across chondrocytes from donors of various ages.” After acute damage with irradiation, DNA repair was shown to be more efficient in chondrocytes from young (≤45 years old) as compared to middle-aged (50–65 years old) or older (>70 years old) cadaveric donors. Activation of SIRT6 with MDL-800 improved the repair efficiency, while inhibition with EX-527 reduced the rate of repair and increased the percentage of cells that retain high levels of damage. In addition to affecting repair after acute damage, treating chondrocytes from older donors with MDL-800 for 48 hours significantly reduced the amount of baseline DNA damage. Chondrocytes isolated from the knees of mice between 4 months and 22 months of age revealed both an increase in DNA damage with aging, and a decrease in DNA damage following MDL-800 treatment. Lastly, treating murine cartilage explants with MDL-800 lowered the percentage of chondrocytes with high p16 promoter activity, which supports the concept that using SIRT6 activation to maintain low levels of DNA damage may prevent the initiation of senescence. “In conclusion, the findings presented here support the hypothesis that the efficiency of DNA damage repair declines with age in chondrocytes and that SIRT6 activation improves repair both in response to an acute irradiation challenge and in the context of age-related damage accumulation. These results emphasize the critical role of SIRT6 in DNA repair and support further studies investigating the use of MDL-800 (or alternative SIRT6 activators) in mitigating senescence induction and ameliorating OA development.” DOI - https://doi.org/10.18632/aging.205394 Corresponding author - Brian O. Diekman - bdiekman@email.unc.edu About Aging-US Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Please visit https://www.Aging-US.com​​ and connect with us: SoundCloud - https://soundcloud.com/Aging-Us Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ MEDIA@IMPACTJOURNALS.COM

In this week's episode we'll see how targeting the prostacyclin receptor is a promising strategy for regulating hemostasis and thrombosis. Then, we'll learn how new evidence indicates that the progression rate is low in MRD-negative myeloma patients who discontinue post-transplant lenalidomide and dexamethasone maintenance therapy after 2 years. Finally we'll discuss how amphiregulin from leptin receptor-positive niche cells in the bone marrow mediates crosstalk between the niche and hematopoietic stem cells under conditions of DNA repair deficiency and aging.

What does the cutting edge of radiation oncology look like for treating triple-negative breast cancer? Tune in to hear experts Drs Kevin Kalinsky and Reshma Jagsi discuss. Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/991257). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals. Resources A Review of Triple-negative Breast Cancer https://www.medscape.com/viewarticle/727195_4 A Review of the Abscopal Effect in the Era of Immunotherapy https://pubmed.ncbi.nlm.nih.gov/36321062/ The Impact of Radiation-induced DNA Damage on cGAS-STING-mediated Immune Responses to Cancer https://pubmed.ncbi.nlm.nih.gov/33238631/ Gray (Gy) https://www.nrc.gov/reading-rm/basic-ref/glossary/gray-gy.html Event-free Survival With Pembrolizumab in Early Triple-negative Breast Cancer https://pubmed.ncbi.nlm.nih.gov/35139274/ Testing MK-3475 (Pembrolizumab) as Adjuvant Therapy for Triple Receptor-negative Breast Cancer https://clinicaltrials.gov/study/NCT02954874 Pre-op Pembro + Radiation Therapy in Breast Cancer (P-RAD) https://clinicaltrials.gov/study/NCT04443348 Translational Breast Cancer Research Consortium (TBCRC) https://tbcrc.org/ Emerging Role of PARP Inhibitors in Metastatic Triple Negative Breast Cancer. Current Scenario and Future Perspectives https://pubmed.ncbi.nlm.nih.gov/34900718/ SWOG Cancer Research Network https://www.swog.org/ BRCA1 and BRCA2 Mutations https://www.ncbi.nlm.nih.gov/books/NBK470239/ Concurrent Veliparib With Chest Wall and Nodal Radiotherapy in Patients With Inflammatory or Locoregionally Recurrent Breast Cancer: The TBCRC 024 Phase I Multicenter Study https://pubmed.ncbi.nlm.nih.gov/29558281/ Radiation Therapy With or Without Olaparib in Treating Patients With Inflammatory Breast Cancer https://clinicaltrials.gov/study/NCT03598257 Breast Cancer and HER2 https://emedicine.medscape.com/article/1689966-overview ER/PgR Testing in Breast Cancer Clinical Practice Guidelines (ASCO/CAP, 2020) https://reference.medscape.com/viewarticle/924542 Oncotype DX Breast Recurrence Score®: A Review of Its Use in Early-stage Breast Cancer https://pubmed.ncbi.nlm.nih.gov/32613290/ Regional Radiotherapy in Biomarker Low-risk Node Positive and T3N0 Breast Cancer (TAILOR RT) https://classic.clinicaltrials.gov/ct2/show/NCT03488693 Postoperative Radiotherapy in High-risk Premenopausal Women With Breast Cancer Who Receive Adjuvant Chemotherapy. Danish Breast Cancer Cooperative Group 82b Trial https://pubmed.ncbi.nlm.nih.gov/9395428/ Postoperative Radiotherapy in High-risk Postmenopausal Breast-cancer Patients Given Adjuvant Tamoxifen: Danish Breast Cancer Cooperative Group DBCG 82c Randomised Trial https://pubmed.ncbi.nlm.nih.gov/10335782/ Risk of Ischemic Heart Disease in Women After Radiotherapy for Breast Cancer https://pubmed.ncbi.nlm.nih.gov/23484825/ Radiotherapy Use and Incidence of Locoregional Recurrence in Patients With Favorable-risk, Node-positive Breast Cancer Enrolled in the SWOG S1007 Trial https://pubmed.ncbi.nlm.nih.gov/37410451/

Episode #280. Ever wondered how the simple act of timing – when you eat, sleep, or even look at your phone – could dramatically affect your health? In this episode, I sit down with circadian biology expert Dr Satchin Panda to explore this concept. We delve into the science of our body's internal clocks and offer practical advice to keep them in sync. Don't miss out on unlocking the potential of your circadian rhythm for a healthier, more balanced life. We discuss: Introduction (0:00) Understanding Circadian Rhythms: Do They Influence Longevity? (1:55) The Role of the Suprachiasmatic Nucleus (SCN) in Circadian Rhythms (6:20) Cellular-Level Circadian Clocks: An Overview (10:33) A Comprehensive Look at Circadian Disruption (15:56) Effective Strategies for Managing Jet Lag (26:39) The Impact of Blue Light on Circadian Rhythms (29:17) Criteria for Diagnosing Circadian Rhythm Disorders (33:42) Sensitivity Factors of Circadian Rhythms (34:58) The Significance of Meal Timing in Circadian Rhythms (39:30) Circadian Rhythms: Their Relation to Cholesterol and Blood Pressure (43:41) Exploring the Link Between Circadian Disruption, DNA Damage, and Cancer Risk (46:49) Circadian Disruption and Its Role in Chronic Disease Risk (49:34) Time-Restricted Eating and Metabolic Health (55:22) Outro (1:06:09) To connect with Dr Satchin Panda, you can find him on Twitter and read his peer-reviewed papers on his profile. To learn more about circadian biology, his books, The Circadian Code and The Circadian Diabetes Code, are an incredible resource. You can also better understand your circadian rhythm while contributing to research with Dr Panda's app, myCircadianClock. Optimise your health with InsideTracker's biomarker analysis. Get exclusive access to InsideTracker's new ApoB test, and a significant discount at insidetracker.com/simon. Enjoy, friends. Simon Want to support the show? The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family. Simon Hill, MSc, BSc (Hons) Creator of theproof.com and host of The Proof with Simon Hill Author of The Proof is in the Plants Watch the episodes on YouTube or listen on Apple/Spotify Connect with me on Instagram, Twitter, and Facebook Nourish your gut with my Plant-Based Ferments Guide Download my complimentary Two-Week Meal Plan and high protein Plant Performance recipe book

In this episode of the Epigenetics Podcast, we caught up with Björn Schumacher from the Institute for Genome Stability in Ageing and Disease at the University of Cologne to talk about his work on DNA damage in longevity and ageing. In this episode Björn Schumacher discusses his research on DNA repair and its impact on ageing. We explore his insights on the effects of DNA damage on transcription, the importance of studying development, and the role of histone modifications. We also discuss paternal DNA damage inheritance and the DREAM complex as a master regulator of DNA repair. The lab's goal is to enhance somatic DNA repair for healthier ageing and disease prevention.   References Schumacher, B., van der Pluijm, I., Moorhouse, M. J., Kosteas, T., Robinson, A. R., Suh, Y., Breit, T. M., van Steeg, H., Niedernhofer, L. J., van Ijcken, W., Bartke, A., Spindler, S. R., Hoeijmakers, J. H., van der Horst, G. T., & Garinis, G. A. (2008). Delayed and accelerated aging share common longevity assurance mechanisms. PLoS genetics, 4(8), e1000161. https://doi.org/10.1371/journal.pgen.1000161 Ermolaeva, M. A., Segref, A., Dakhovnik, A., Ou, H. L., Schneider, J. I., Utermöhlen, O., Hoppe, T., & Schumacher, B. (2013). DNA damage in germ cells induces an innate immune response that triggers systemic stress resistance. Nature, 501(7467), 416–420. https://doi.org/10.1038/nature12452 Wang, S., Meyer, D. H., & Schumacher, B. (2023). Inheritance of paternal DNA damage by histone-mediated repair restriction. Nature, 613(7943), 365–374. https://doi.org/10.1038/s41586-022-05544-w Bujarrabal-Dueso, A., Sendtner, G., Meyer, D. H., Chatzinikolaou, G., Stratigi, K., Garinis, G. A., & Schumacher, B. (2023). The DREAM complex functions as conserved master regulator of somatic DNA-repair capacities. Nature structural & molecular biology, 30(4), 475–488. https://doi.org/10.1038/s41594-023-00942-8   Related Episodes Effects of Environmental Cues on the Epigenome and Longevity (Paul Shiels) Transposable Elements in Gene Regulation and Evolution (Marco Trizzino) Epigenetic Clocks and Biomarkers of Ageing (Morgan Levine)   Contact Epigenetics Podcast on Twitter Epigenetics Podcast on Instagram Epigenetics Podcast on Mastodon Active Motif on Twitter Active Motif on LinkedIn Email: podcast@activemotif.com

BUFFALO, NY- September 20, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 17, entitled, “Development of a DNA damage-induced senescence model in osteoarthritic chondrocytes.” Senescent cells (SnCs) have been described to accumulate in osteoarthritis (OA) joint tissues in response to injury, thereby participating in OA development and progression. However, clinical therapeutic approaches targeting SnCs using senolysis, although promising in preclinical OA models, have not yet proven their efficacy in patients with knee OA. This pitfall may be due to the lack of understanding of the mechanisms underlying chondrocyte senescence. In their new study, researchers Mélina Georget, Anaïs Defois, Romain Guiho, Nina Bon, Sophie Allain, Cécile Boyer, Boris Halgand, Denis Waast, Gaël Grimandi, Alban Fouasson-Chailloux, Jérôme Guicheux, and Claire Vinatier from Nantes Université aimed to generate models of chondrocyte senescence. “In this context, our study aims to develop in vitro models of chondrocyte senescence by investigating the ability of etoposide and IL-1β treatments to produce a reliable chondrocyte senescent model.” This study used etoposide, to induce DNA damage-related senescence or chronic exposure to IL-1β to entail inflammation-related senescence in human OA chondrocytes. Several hallmarks of cellular senescence, such as cell cycle arrest, expression of cyclin-dependent kinase inhibitors, DNA damages, and senescence-associated secretory profile were evaluated. Chronic exposure to IL-1β induces only partial expression of senescence markers and does not allow us to conclude on its ability to induce senescence in chondrocytes. On the other hand, etoposide treatment reliably induces DNA damage-related senescence in human articular chondrocytes evidenced by loss of proliferative capacity, DNA damage accumulation, and expression of some SASP components. “Etoposide-induced senescence model may help investigate the initiation of cellular senescence in chondrocytes, and provide a useful model to develop therapeutic approaches to target senescence in OA.” DOI - https://doi.org/10.18632/aging.204881 Corresponding author - Claire Vinatier - claire.vinatier@univ-nantes.fr Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.204881 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, senescence, osteoarthritis, etoposide, chondrocytes About Aging-US Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Please visit our website at https://www.Aging-US.com​​ and connect with us: SoundCloud - https://soundcloud.com/Aging-Us Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Media Contact 18009220957 MEDIA@IMPACTJOURNALS.COM

UV nail dryers cause DNA damage - with Dr. Julia Curtis! Cantharidin 0.7% for Molluscum - Imiquimod 5% cream for LM - TNF inhibitor induced Psoriasis - Memantine for Trichotillomania & Skin Picking - Check out our video content on YouTube: ⁠Dermasphere Podcast - YouTube⁠ - and VuMedi!: https://www.vumedi.com/channel/dermasphere/ The University of Utah's Dermatology ECHO: ⁠⁠https://physicians.utah.edu/echo/dermatology-primarycare - ⁠⁠Connect with us! - Web: ⁠https://dermaspherepodcast.com/⁠ - Twitter: @DermaspherePC - Instagram: dermaspherepodcast - Facebook: https://www.facebook.com/DermaspherePodcast/ - Check out Luke and Michelle's other podcast, SkinCast! ⁠https://healthcare.utah.edu/dermatology/skincast/⁠ Luke and Michelle report no significant conflicts of interest… BUT check out our friends at: - ⁠Kikoxp.com ⁠(a social platform for doctors to share knowledge) - ⁠https://www.levelex.com/games/top-derm⁠ (A free dermatology game to learn more dermatology!)

Folks, on this week's episode we hear about a mysterious god orb from the ocean, how NASA may have accidentally killed some Martians years ago, vandals breaking through the great wall of China, NYC rat tours, and caffeine instant ramen for gamers Become a patron for weekly bonus eps and more stuff!: www.patreon.com/whatatimepod Check out our YouTube channel: https://www.youtube.com/c/whatatimetobealive Get one of our t-shirts, or other merch, using this link! https://whatatimepod.bigcartel.com/ whatatimepod.com Join our Discord chat here: discord.gg/jx7rB7J @pattymo // @kathbarbadoro // @eliyudin // @whatatimepod © 2023 What A Time LLC

Space radiation can cause breaks in the entwined strands of DNA that carry genetic information.

Join Laura and Jaci Stephans as we go over and discuss the Carnivore Diet.Research:Carnivore Code Book Other ResearchWhat is Phytase - https://www.webmd.com/vitamins/ai/ingredientmono-1619/phytasePhytase and Human Nutrition - https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3434231#:~:text=Phytases%20have%20been%20identified%20in,konietzny%20and%20greiner%2C%202002).Phytic Acid and DNA Damage - https://pubmed.ncbi.nlm.nih.gov/11676478/Phytic Acid and Inositol for Improved Insulin Sensitivity - https://www.sciencedirect.com/science/article/abs/pii/S0271531714001225?via%3DihubAre AntiNutritients Harmful - https://www.hsph.harvard.edu/nutritionsource/anti-nutrients/Stone Age Humans and Plant Glucose - https://ec.europa.eu/research-and-innovation/en/horizon-magazine/how-stone-age-humans-unlocked-glucose-plantsThe Paleolithic Diet - https://www.ncbi.nlm.nih.gov/books/NBK482457/#:~:text=Plants%20%2D%20These%20included%20tubers%2C%20seeds,process%20and%20cook%20these%20foods.To learn more visit www.ShiftHealthCoach.comSupport the showSchedule a free 15 session with me or purchase a full session and walk away with an actionable plan. To learn more, visit www.ShiftHealthCoach.comMusic by Alex Grohl and Pixabay click here to listen to learn more

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.14.549060v1?rss=1 Authors: Stanczyk, P. J., Tatekoshi, Y., Shapiro, J. S., Nayudu, K., Chen, Y., Zeilber, Z., Schipma, M., De Jesus, A., Mahmoodzadeh, A., Akrami, A., Chang, H.-C., Ardehali, H. Abstract: BACKGROUND: Proper nuclear organization is critical for cardiomyocyte (CM) function, as global structural remodeling of nuclear morphology and chromatin structure underpins the development and progression of cardiovascular disease. Previous reports have implicated a role for DNA damage in cardiac hypertrophy, however, the mechanism for this process is not well delineated. AMPK family of proteins regulate metabolism and DNA damage response (DDR). Here, we examine whether a member of this family, SNF1-related kinase (SNRK), which plays a role in cardiac metabolism, is also involved in hypertrophic remodeling through changes in DDR and structural properties of the nucleus. METHODS: We subjected cardiac specific (cs)-Snrk-/- mice to trans-aortic banding (TAC) to assess the effect on cardiac function and DDR. In parallel, we modulated SNRK in vitro and assessed its effects on DDR and nuclear parameters. We also used phospho-proteomics to identify novel proteins that are phosphorylated by SNRK. Finally, co-immunoprecipitation (co-IP) was used to verify Destrin (DSTN) as the binding partner of SNRK that modulates its effects on the nucleus and DDR. RESULTS: cs-Snrk-/- mice display worse cardiac function and cardiac hypertrophy in response to TAC, and an increase in DDR marker pH2AX in their hearts. Additionally, in vitro Snrk knockdown results in increased DNA damage and chromatin compaction, along with alterations in nuclear flatness and 3D volume. Phospho-proteomic studies identified a novel SNRK target, DSTN, a member of F-actin depolymerizing factor (ADF) proteins that directly binds to and depolymerize F-actin. SNRK binds to DSTN, and DSTN downregulation reverses excess DNA damage and changes in nuclear parameters, in addition to cellular hypertrophy, with SNRK knockdown. We also demonstrate that SNRK knockdown promotes excessive actin depolymerization, measured by the increased ratio of globular (G-) actin to F-actin. Finally, Jasplakinolide, a pharmacological stabilizer of F-actin, rescues the increased DNA damage and aberrant nuclear morphology in SNRK downregulated cells. CONCLUSIONS: These results indicate that SNRK is a key player in cardiac hypertrophy and DNA damage through its interaction with DSTN. This interaction fine-tunes actin polymerization to reduce DDR and maintain proper CM nuclear shape and morphology. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Research shows sucralose, commonly known as Splenda, causes DNA damage, leaky gut and alters genes that regulate inflammation and cancer. I could have told them that. I mean chlorine in food! A cancer causing chemical in food! Also, research is showing horrible brain functioning implications. Listen now.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.02.547436v1?rss=1 Authors: Ozato, K., Wu, T., Hou, H., Dey, A., Bachu, M., Chen, X., Wisniewski, J., Kudoh, F., Chen, C., Chauhan, S., Xiao, H., Pan, R. Abstract: BRD4 binds to acetylated histones to regulate transcription and drive cancer cell proliferation. However, the role of BRD4 in normal cell growth remains to be elucidated. Here we investigated the question by using mouse embryonic fibroblasts with conditional Brd4 knockout (KO). We found that Brd4KO cells grow more slowly than wild type cells: they do not complete replication, fail to achieve mitosis, and exhibit extensive DNA damage throughout all cell cycle stages. BRD4 was required for expression of more than 450 cell cycle genes including genes encoding core histones and centromere/kinetochore proteins that are critical for genome replication and chromosomal segregation. Moreover, we show that many genes controlling R-loop formation and DNA damage response (DDR) require BRD4 for expression. Finally, BRD4 constitutively occupied genes controlling R-loop, DDR and cell cycle progression. We suggest that BRD4 epigenetically marks those genes and serves as a master regulator of normal cell growth. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.06.29.547089v1?rss=1 Authors: Araki, D., Chen, V., Redekar, N., Salisbury-Ruf, C., Luo, Y., Liu, P., Li, Y., Smith, R., Dagur, P., Combs, C., Larochelle, A. Abstract: Granulocyte colony stimulating factor (G-CSF) is commonly used as adjunct treatment to hasten recovery from neutropenia following chemotherapy and autologous transplantation of hematopoietic stem and progenitor cells (HSPCs) for malignant disorders. However, the utility of G-CSF administration after ex vivo gene therapy procedures targeting human HSPCs has not been thoroughly evaluated. Here, we provide evidence that post-transplant administration of G-CSF impedes engraftment of CRISPR-Cas9 gene edited human HSPCs in xenograft models. G-CSF acts by exacerbating the p53-mediated DNA damage response triggered by Cas9-mediated DNA double-stranded breaks. Transient p53 inhibition in culture attenuates the negative impact of G-CSF on gene edited HSPC function. In contrast, post-transplant administration of G-CSF does not impair the repopulating properties of unmanipulated human HSPCs or HSPCs genetically engineered by transduction with lentiviral vectors. The potential for post-transplant G-CSF administration to aggravate HSPC toxicity associated with CRISPR-Cas9 gene editing Cas9 should be considered in the design of ex vivo autologous HSPC gene editing clinical trials. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.06.27.546688v1?rss=1 Authors: Sutcu, H., Rassinoux, P., Donnio, L.-M., Neuillet, D., Vianna, F., Gabillot, O., MARI, P.-O., Baldeyron, C., Giglia-Mari, G. Abstract: DNA integrity is incessantly confronted to endogenous and exogenous agents inducing DNA lesions, which are harmful for cellular homeostasis. Luckily all organisms are equipped with a network of DNA damage response (DDR) mechanisms that will repair DNA lesions and restore the proper cellular activities. Despite DNA repair mechanisms have been revealed in vitro and in replicating cells, still little is known on how DNA lesions are repaired and consequently how cellular homeostasis is maintained in post-mitotic cells. Muscle fibers are highly specialised post-mitotic cells organized in syncytia and, they are vulnerable to age-related degeneration and atrophy following radiotherapy treatment. We have here studied in detail the DNA repair capacity of muscle fibers nuclei and compared it with the one measured in proliferative myoblasts. We focused on the DNA repair mechanisms that correct ionizing radiation (IR)-induced lesions, namely the base excision repair (BER), the non-homologous end joining (NHEJ) and the homologous recombination (HR). We found that in the most differentiated myogenic cells, myotubes, all of these DNA repair mechanisms present weakened kinetics of recruitment of DNA repair proteins to IR-damaged DNA. For BER and HR, this decline can be linked to reduced steady state levels of key proteins involved in these processes, probably since nuclei within muscle fibers no longer replicate their DNA. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Dr Rob waxes eloquent about some amazing new revelations involving DNA damage repair systems. Researchers recently turned AI onto the human genome, probing the genes and gene systems that are involved in maintaining and repairing DNA. The results shocked everyone. Many more genes that anyone thought are required, and entire new repair systems were discovered. So what came first, DNA or the amazing repair systems required to maintain DNA that are, in turn, coded into DNA? The point is that these systems are absolutely necessary for living things, yet they are also incredibly complicated. They would never be expected to arise without help, but without them the entire DNA system (not just the code, but the DNA itself) could never exist. Evolution, in this case, simply fails to explain much of anything. Links: Kratz et al. 2023. A multi-scale map of protein assemblies in the DNA damage response. Cell Syst 14(6):447-463.e8; https://pubmed.ncbi.nlm.nih.gov/37220749/

Are you tired of the same old cancer treatment methods that leave you feeling drained and hopeless? Look no further than the Integrative Cancer Solutions with Dr. Karlfeldt. In our latest episode, we have Dr. Stephen Iacoboni, a medical oncologist with over 40 years of experience, discussing the use of naturopathic remedies alongside chemotherapy to overcome drug resistance. Our goal is to educate and inform our listeners about alternative cancer solutions that have been successful for others. Dr. Iacoboni shares his expertise in integrative oncology and explains why he believes that academic institutions have a primary mission of research, while a doctor in the community has a primary mission of patient care. The conversation also touches on the pros and cons of chemotherapy and the emerging direction of immunotherapy. Join us as we explore the history and progress of cancer treatment, breakthroughs in oncology, and alternative tools and treatments. Don't miss out on this informative and eye-opening episode. Tune in to Integrative Cancer Solutions with Dr. Karlfeldt today.- Alternative cancer treatments- Naturopathic remedies- Integrative oncology- Evolution of medical oncology- Pros and cons of chemotherapy- Immunotherapy limitations- Insulin Potentiated Therapy- Hyperoxidative therapy- Exploiting cancer cell vulnerabilities- Antioxidants and cancer- Nutraceuticals in cancer treatment- Revolution in oncology- Telos book and purpose in life- Scientific atheism and faith- Patient-centered care- Educational purposes only- Karlfeldt Center promotionKEY POINTS[0:0:32] With integrative and holistic methods, it's possible to WIN the fight against cancer.[0:5:16] Academic institutions are dedicated to pushing the boundaries of knowledge, while doctors are devoted to providing life-saving care to their patients.[0:8:53] In the last four decades, medical oncology has seen a remarkable transformation, from primitive radiation and surgical treatments to the development of revolutionary chemotherapy and immunotherapy treatments.[0:14:22] Shockingly, traditional cancer therapies often come with debilitating side effects - but luckily, there are now alternative solutions available![0:16:44] Miraculously, over 90% of early stage cancer cases can be successfully cured – giving hope to those facing the devastating diagnosis of stage four cancer.[0:21:39] By strategically targeting the oxidative state of cancer cells with Vitamin C and K3 at a specific ratio, researchers have uncovered an incredibly empowering and overlooked vulnerability in the fight against cancer.[0:22:10] Chemotherapy is a much less lethal and more effective alternative to Cyanide for treating cancer, with the power to eradicate cancerous cells on a much larger scale.[0:26:25] Cancer cells exhibit an alarming, frenetic energy level, devouring vast amounts of energy to fuel their rapid growth.[0:27:42] By leveraging the power of Prooxidants, cancer cells can be efficiently destroyed with reduced chemo doses, effectively cutting off their crucial supply of antioxidants![0:30:20] Despite the exorbitant price of cancer medications, some physicians prioritize patient health above profit, delivering effective and accessible treatments to improve the lives of those affected.[0:36:22] By revolutionizing oncology, we could dramatically reduce Medicare costs, saving billions of dollars and dramatically improving the lives of countless patients.[0:46:24] Incredibly, nutraceuticals with hyperoxidation properties have the potential to halt the progression of pre-cancerous cells, offering a cost-effective alternative to traditional cancer prevention methods. Connect with Stephen at https://stepheniacoboni.com/ Integrative Cancer Solutions was created to instill hope and empowerment. Other people have been where you are right now and have already done the research for you. Listen to their stories and journeys and apply what they learned to achieve similar outcomes as they have, cancer remission and an even more fullness of life than before the diagnosis. Guests will discuss what therapies, supplements, and practitioners they relied on to beat cancer. Once diagnosed, time is of the essence. This podcast will dramatically reduce your learning curve as you search for your own solution to cancer. For more information about products and services discussed in this podcast, please visit www.integrativecancersolutions.com. To learn more about the cutting-edge integrative cancer therapies Dr. Karlfeldt offer at his center, please visit www.TheKarlfeldtCenter.com.

Episode 51: In this episode, host Angie Gust talks about the benefits of ashwagandha and moringa. These are dietary supplements that could help heal ourselves and maybe even the planet. Ashwaganda is an herb and moringa is a tree.  They both have some amazing properties and can live in arid conditions so they may be good for climate change- taking in CO2 without needing much water. Turning to the environment, last May, the  United States hosted the Agriculture Innovation Mission to bring together partners to increase and accelerate investment in and support for agriculture and food systems innovation for climate action.  It highlighted opportunities for climate solutions and climate-smart agriculture and food systems innovation in the lead-up to COP28 which is in the United Arab Emirates in November this year. References Adjonyoh, Z. Mar 9, 2021. What is moringa? Everything you need to know about the superfood. Today. https://www.today.com/food/moringa-health-benefits-what-know-about-superfood-t210949 DeSouza,J Apr 20, 2023 Creating Fabric Materials out of Bacteria. Happy Eco News.https://happyeconews.com/creating-fabric-materials-out-of-bacteria/ Horn, L, Natalia Shakela, Marius K. Mutorwa, Erold Naomab, Habauka M. Kwaambwa. Moringa oleifera as a sustainable climate-smart solution to nutrition, disease prevention, and water treatment challenges: A review, Journal of Agriculture and Food Research, Volume 10, 2022, 100397, Mikulska, P et al.  Ashwagandha (Withania somnifera)—Current Research on the Health-Promoting Activities: A Narrative Review. Pharmaceutics 2023, 15(4), 1057; https://doi.org/10.3390/pharmaceutics15041057 Raguraman, VR, Subramaniam, JR. Withania somnifera Root exrtract increases telomerase activity I the human HeLa cell line. Adv. Biosci Biotechnol 2016; 7:199-204. Sharma R, Martins N. Telomeres, DNA Damage and Ageing: Potential Leads from Ayurvedic Rasayana (Anti-Ageing) Drugs. J Clin Med. 2020 Aug 6;9(8):2544. doi: 10.3390/jcm9082544. PMID: 32781627; PMCID: PMC7465058. Sierra Club. Toiyabe Chapter. 100 things you can do to save the planet.https://www.sierraclub.org/toiyabe/100-things-you-can-do-save-planet Stohs SJ, Hartman MJ. Review of the Safety and Efficacy of Moringa oleifera. Phytother Res. 2015 Jun;29(6):796-804. doi: 10.1002/ptr.5325. Epub 2015 Mar 24. PMID: 25808883; PMCID: PMC6680322. USDA May 10, 2023 Final Day of AIM for Climate Summit Announces Groundbreaking Initiatives on the Road to COP28. https://www.usda.gov/media/press-releases/2023/05/10/final-day-aim-climate-summit-announces-groundbreaking-initiatives      

A new research paper was published in Oncotarget's Volume 14 on June 12, 2023, entitled, “LP-284, a small molecule acylfulvene, exerts potent antitumor activity in preclinical non-Hodgkin's lymphoma models and in cells deficient in DNA damage repair.” Despite advances in therapies treating non-Hodgkin's lymphoma (NHL), 20~40% of patients experience relapsed or refractory disease. While solid tumors with homologous recombination deficiencies have been successfully targeted with synthetic lethal agents such as poly-ADP ribose polymerase (PARP) inhibitors, such synthetic lethality strategy has not yet been approved to treat patients with NHL. In this new study, researchers Jianli Zhou, Drew Sturtevant, Cassie Love, Aditya Kulkarni, Neha Biyani, Umesh Kathad, Elizabeth Thacker, Sandeep Dave, and Kishor Bhatia from Lantern Pharma Inc., Duke University and Data Driven Bioscience investigated the mechanism of action (MoA) and therapeutic potential of a new-generation acylfulvene compound, LP-284, in both in vitro and in vivo NHL models. “Here, we aimed to characterize LP-284's antitumor efficacy in NHL models and further elucidate its mechanisms of action.” One of LP-284's MoA includes inducing the repair of double-strand DNA break (DSB). The researchers found that LP-284 exerts nanomolar potency in a panel of hematological cancer cell lines including fifteen NHL cell lines. In vivo, LP-284 treatment prolongs the survival of mantle cell lymphoma (MCL) cell line JeKo-1 derived xenograft mice by two-fold and shows increased efficacy over bortezomib and ibrutinib. In addition, LP-284 is capable of inhibiting tumor growth of JeKo-1 xenografts that are refractory to bortezomib or ibrutinib. They further showed that LP-284 is particularly lethal in cells with deficient DNA damage response and repair, a targetable vulnerability in NHL. “In conclusion, our study has demonstrated LP-284 as a novel and potent acylfulvene drug that can suppress tumor growth in NHL models and cells with HR or TC-NER deficiency.” DOI - https://doi.org/10.18632/oncotarget.28454 Correspondence to - Jianli Zhou - jianli@lanternpharma.com Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28454 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - non-Hodgkin's lymphoma, DNA damage, homologous recombination repair, transcription-coupled nucleotide excision repair, ATM About Oncotarget Oncotarget is a primarily oncology-focused, peer-reviewed, open access journal. Papers are published continuously within yearly volumes in their final and complete form, and then quickly released to Pubmed. On September 15, 2022, Oncotarget was accepted again for indexing by MEDLINE. Oncotarget is now indexed by Medline/PubMed and PMC/PubMed. To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: SoundCloud - https://soundcloud.com/oncotarget Facebook - https://www.facebook.com/Oncotarget/ Twitter - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957

Hugues de ThéCollège de France - Année 2022-2023Oncologie cellulaire et moléculaireColloque - Revisited Chemotherapy : Killing Cancer by DNA Damage Through Synthetic LethalityThomas Helleday, Karolinska Institutet, Stockholm, Suède

Today you'll learn about new treatments the wealthy are using to try and stay young forever, the cultural and social evolution of the word please, and how the snap fit mechanism used in things like lego bricks is being updated for even bigger projects. Find episode transcripts here: https://curiosity-daily-4e53644e.simplecast.com/episodes/immortality-tech-please-is-not-polite-snap-fit-physicsImmortality Tech “People are desperately trying to live forever. Here are the biggest anti-aging trends sweeping the nation.” by Lakshmi Varanasihttps://finance.yahoo.com/news/people-desperately-trying-live-forever-090000189.html“Taking the Plunge: Is Cold Exposure Worthwhile?” by Lisa Fieldshttps://www.cedars-sinai.org/blog/cold-exposure-therapy.html“How can fasting help fight aging?” by Linnea Zielinskihttps://ro.co/health-guide/fasting-and-aging/?irclickid=SG20AsU8gxyNTy0TnAXIvwzyUkAW13QJMWdhz80&irgwc=1&utm_source=impact&utm_medium=affiliate&utm_campaign=10078&utm_content=1262348&utm_term=businessinsider.com&ro_con=1&ro_ch=pubs&ro_p=impact&ro_n=Skimbit%20Ltd.&ro_c=10078&ro_g=Online%20Tracking%20Link&ro_t=1262348&survey_code=Skimbit%20Ltd.“Telomeres, DNA Damage and Ageing: Potential Leads from Ayurvedic Rasayana (Anti-Ageing) Drugs” by Rohit Sharma and Natália Martinshttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465058/“Red Light Therapy” by Cleveland Clinichttps://my.clevelandclinic.org/health/articles/22114-red-light-therapyPlease Is Not Polite “How Please Stopped Being Polite” By Walker Mimmshttps://www.theatlantic.com/family/archive/2023/03/polite-words-is-please-rude/673397/“Oh Please Stop Saying Please” by Choire Sichahttps://www.nytimes.com/2018/12/20/business/ghosting-your-job.html“7 words you probably didn't know were acronyms” by BBChttps://www.bbc.co.uk/programmes/articles/2grMKJ29Ghlw36WXCHGJvKk/7-words-you-probably-didnt-know-were-acronymsSnap Fit Physics  “From LEGOs to Ziploc: The Science of the Snap Fit” by Katharine Gammonhttps://www.insidescience.org/news/legos-ziploc-science-snap-fit“Mechanics of a Snap Fit” by Keisuke Yoshida and Hirofumi Wadahttps://journals.aps.org/prl/abstract/10.1103/PhysRevLett.125.194301“LEGO ‘snap-fit' inspires scientific study” by Adam Baschhttps://www.brickfanatics.com/lego-snap-fit-inspires-scientific-studyFollow Curiosity Daily on your favorite podcast app to get smarter with Calli and Nate — for free! Still curious? Get exclusive science shows, nature documentaries, and more real-life entertainment on discovery+! Go to https://discoveryplus.com/curiosity to start your 7-day free trial. discovery+ is currently only available for US subscribers.

This episode of the Rejuvenation Roundup Podcast features our Rejuvenation Roundup, as well as two Lifespan News Shorts and a Life Noggin video on depression. You can also subscribe on your favorite podcasting platform. Learn more at lifespan.io/roundup 0:00 Intro 0:38 Low Carb Intake Linked to Insulin Resistance (1) 2:22 Rapamycin Rescues Age-Impaired Blood Flow in Mice (2) 4:53 Sleep Quality and Duration Associated with Stroke (3) 7:54 Life Noggin: Are You Stuck in the Depression Loop? (4) 11:41 Lifespan News Short: "Young Gut" Microbiome Associated with Longevity (5) 12:49 Lifespan News Short: DNA Damage Repair No Longer a DREAM (6) Links: 1 - https://www.lifespan.io/news/low-carb-intake-linked-to-insulin-resistance/ 2 - https://www.lifespan.io/news/rapamycin-rescues-age-impaired-blood-flow-in-mice/ 3 - https://www.lifespan.io/news/sleep-quality-and-duration-associated-with-stroke/ 4 - https://youtu.be/XY5jYPta0uQ 5 - https://youtube.com/shorts/zUc-n254nw0 6 - https://youtube.com/shorts/h6DNxSwQ7YE

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.04.06.535882v1?rss=1 Authors: Ciotta, G., Singh, S., Gupta, A., Torres, D. C., Fu, J., Choudhury, R., Chu, W. K., Choudhary, C., Gahurova, L., Al-Fatlawi, A., Schroeder, M., Aasland, R., Poetsch, A., Anastassiadis, K., Stewart, A. F. Abstract: SETD1A is the histone 3 lysine 4 (H3K4) methyltransferase central to the mammalian version of the highly conserved eight subunit Set1 complex (Set1C) that apparently conveys H3K4 trimethylation (H3K4me3) onto all active Pol II promoters. Accordingly, mouse embryonic stem cells (ESCs) die when SETD1A is removed. We report that death is accompanied by loss of expression of DNA repair genes and accumulating DNA damage. BOD1L and BOD1 are homologs of the yeast Set1C subunit, Shg1, and subunits of the mammalian SETD1A and B complexes. We show that the Shg1 homology region binds to a highly conserved central a-helix in SETD1A and B. Like mutagenesis of Shg1 in yeast, conditional mutagenesis of Bod1l in ESCs promoted increased H3K4 di- and tri-methylation but also, like loss of SETD1A, loss of expression of DNA repair genes, increased DNA damage and cell death. In contrast to similar losses of gene expression, the converse changes in H3K4 methylation implies that H3K4 methylation is not essential for expression of the DNA repair network genes. Because BOD1L becomes highly phosphorylated after DNA damage and acts to protect damaged replication forks, the SETD1A complex and BOD1L in particular are key nodes for the DNA damage repair network. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Locally recurrent prostate cancer from 53 patients that failed radiation therapy and underwent salvage radical prostatectomy was analyzed for clinicopathological and genomic characteristics. Most radiorecurrent tumors were enriched in cribriform morphologies (invasive cribrifom PCa and intraductal carcinoma with cribriform pattern) and demonstrated potentially targetable genomic alterations (defects in DDR genes: TP53, BRCA2, PALB2, ATR etc.). The guest, Dr. Rajal Shah of UTSW, discusses how understanding this phenotypic and genotypic diversity of radiorecurrent PCa is critically important for future management of such patients. Hosted on Acast. See acast.com/privacy for more information.

Dr Akila Viswanathan talks with Dr Michael Goldstein about his research into DNA Damage Response and how the damage to the DNA of cancer cells can be exploited to better treat patients.

An inch wide and a mile deep—that's the sort of expertise CSO of Artios Pharma, Dr. Graeme Smith, brings his benchtop. Since his time at Cambridge, Smith has been laser focused on DDR mechanisms, first elucidating, and then translating those observations to create the PARP inhibitor drug, Lynparza. Developed at Kudos Pharma, and later, AstraZeneca, hear Smith recall his “aha” moment for this first-in-class blockbuster drug, as well as his descriptions of his two new DDR-targeting, clinical stage assets developed at Artios that leverage his knowledge of novel DDR pathways—including those that will overcome resistance to PARP inhibition.

DO YOU STRUGGLE WITH MEMORY or BRAIN FOG? Listen up. Today's episode will explain some of the latest research in the field of genetics related to memory and we'll discuss what it means for you.You will learn:0:52 exercise can reverse neuro degeneration 1:08 exercise is a potent epigenetic modifier5:16 Do you get the blank stare from your teens? Here's why... 15:16 Direct to consumer genetic companies are missing the markBe sure to register for the upcoming Gene Hack Boot Camp if you are looking to optimize your performance or you are simply a biohacker that wants to cover all the bases. The next Boot Camp starts September 20!https://drbriangbrown.com/genehackConnect with Dr Brian on FB/IG/LinkedIn@Dr Brian G Brown

Melanie Avalon: *** Follow me on Instagram: https://www.instagram.com/renatoautore/ ***Follow Melanie Avalon: https://www.instagram.com/melanieavalon/ Intermittent Fasting Facebook Group: https://www.facebook.com/groups/PaleoOMAD Melanie's Free guides: https://melanieavalon.com/guides/ Get 10$ off on the best gut test out there: Viome ( insert code "Renato" at checkout for discount ) https://www.viome.com/ --- FULL DISCLAIMER: All the content and info shared in this episode, and this podcast is for informational and entertainment purposes only. I am not a doctor, and the shared content through this episode and podcast DOES NOT constitute medical advice. Always consult a doctor for any health-related enquiries. --- In this episode - What is Biohacking - Deuterium-depleted Water: You can drink deuterium-depleted water, or you can get rid of deuterium with red-light therapy, fasting or certain types of diets. Some Deuterium Studies: Deuterium Content of Water and Depression https://www.ncbi.nlm.nih.gov/pubmed/25092571, Deuterium Depleted Water and Cancer https://www.ncbi.nlm.nih.gov/pubmed/26826644 Deuterium Depletion and Ageing https://www.ncbi.nlm.nih.gov/pubmed/22561170 Deuterium Depleted Water and Protection from DNA Damage https://www.ncbi.nlm.nih.gov/pubmed/26728727 - Intermittent Fasting: how it works and why it is very good for your body - Intermittent Fasting for Women - Low Carbs/High Fat vs Low Fat/High Carbs: A surprising Study https://pubmed.ncbi.nlm.nih.gov/15897479/ - Surprising facts about Fats - The Scam about many "Healthy" foods. - Lung Capacity and longevity - Cryotherapy's Benefits Resources Mentioned in the episode: - Affordable Deuterium Depleted Water: https://bit.ly/3wAehXZ - H Tablets: https://iherb.co/6M157k6 - Book Metabolical: https://www.amazon.com/Metabolical-Processed-Nutrition-Modern-Medicine-ebook/dp/B08F7S58JY/ref=sr_1_1?crid=2G2X54JXJKFWO&keywords=metabolical&qid=1622164208&sprefix=metabolical%2Caps%2C767&sr=8-1 - The Set Points Diet: https://www.amazon.com/Setpoint-Diet-21-Day-Program-Permanently/dp/0316483834/ref=sr_1_1?dchild=1&keywords=jonathan+set+points&qid=1622164426&sr=8-1 - The best Biohacking Book out there ( Affiliate Link): https://store.biohackingbook.com/?aff=52 --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app Support this podcast: https://anchor.fm/renato-capasso/support

Rowena Gates is a principal and vice president of the Eng3 Corporation, a life science technology company addressing health, wellness, and performance. She’s also a serial entrepreneur which is so inspiring to me personally. Prior to joining Eng3, she spent six years as the founder and CEO of Aviarc, a company that provided Internet-based solutions for international …

Rowena Gates is a principal and vice president of the Eng3 Corporation, a life science technology company addressing health, wellness, and performance. She’s also a serial entrepreneur which is so inspiring to me personally. Prior to joining Eng3, she spent six years as the founder and CEO of Aviarc, a company that provided Internet-based solutions for international …