Podcasts about dna damage

What if aging isn't simply your body “wearing out”… but your body losing the ability to repair itself? In this episode, Dr. Andrew Salzman joins Dr. Josh Axe to explain why chronic inflammation, leaky gut, and depleted NAD may quietly drain the very energy your cells need to heal, think, move, and survive. Uncover what's really going on in your body with advanced biomarker testing for hormones, thyroid, and metabolism— plus a 1-hour consultation with a Senior Health Advisor! →  http://mybloodwork.com Thank you to our sponsors! Sunlighten Sauna: https://get.sunlighten.com/axepodcast Manukora Manuka Honey: https://manukora.com/axe Caraway Home: carawayhome.com/drjoshaxe (Use code DRJOSHAXE) for an exclusive discount Watch The Dr. Josh Axe Show every Monday & Thursday on YouTube: https://www.youtube.com/@drjoshaxe?sub_confirmation=1

Dr. Kassam explains how hormones, IGF-1, nitrates, and saturated fat in dairy and meat promote cancer growth and DNA damage. #CancerRiskFactors #DairyAndCancer #MeatAndCancer #NutritionMechanisms

Andrew Huberman takes it. Peter Attia has been talking about it for years. Every serious longevity researcher has an opinion on it. And by age 40 to 60, your levels have already dropped by 50%. NAD+ is one of the most important molecules in your body. It powers energy production in every cell, repairs DNA damage every single day, and activates the cellular pathways that regulate aging, inflammation, and metabolic function. The biology is not hype. But the way most people are taking it right now almost guarantees it is doing nothing. And Dr. G is done watching people waste their money on the wrong molecule in the wrong form at the wrong dose. In this episode, you will learn:  • Why you cannot raise your cellular NAD+ levels by swallowing NAD+ directly, what happens to the molecule in your digestive tract, and the precursors that actually work  • The clinical research on NR vs NMN, which one has more published human trial data, which one the longevity research community is most excited about, and why sublingual delivery changes everything  • Why the serving sizes on most NAD+ labels are set to make the price look reasonable rather than match the research, and what a therapeutic dose actually looks like Plus the specific brands Dr. G uses and trusts, and how to test your own intracellular NAD+ levels before and after to see if your stack is actually working. Timestamps: 0:00 - NAD+ Drops 50% Between Ages 40 and 60 — Here's Why That Matters  1:37 - What NAD+ Actually Does in Every Cell of Your Body  2:15 - The Fatigue, DNA Damage & Accelerated Aging Tied to NAD+ Decline  3:39 - The Real Question: Is What You're Buying Actually Doing Anything?  4:09 - Why You Cannot Raise NAD+ by Swallowing NAD+ Directly  4:59 - The Three Precursors That Actually Work: Niacin, NR & NMN Explained  6:49 - NR vs. NMN: What the Latest 2026 Research Actually Says  7:34 - Why Most NAD+ Products on the Market Are Dangerously Underdosed  9:06 - Who Should Actually Be Taking NAD+ Precursors (And Who Can Wait)  10:14 - Dr. G's Clinical Recommendation: Sublingual NMN, Proper Dosing & Resveratrol Stacking 11:28 - How to Test Your NAD+ Levels Before and After Supplementing  11:42 - The Brands Dr. G Recommends Learn more about your ad choices. Visit megaphone.fm/adchoices

Looking for the latest on photoprotection? We've got the expert. This week, we're joined by Dr. Naiem Issa as he walks us through the cutting edge research surrounding sun protection and DNA damage repair. Listen in as he discusses the effects of ultraviolet light, proper sun protection, and new therapies for repairing sun damaged skin. Each Thursday, join Dr. Raja and Dr. Hadar, board-certified dermatologists, as they share the latest evidence-based research in integrative dermatology. For access to CE/CME courses, become a member at LearnSkin.com.

How CD38, PARP, and Leaky Gut Are Destroying Your NAD Levels | Dr. Andrew Salzman Your NAD is being drained by two hidden enzymes, your gut may be the starting point of every aging process in your body, and creatine does something to your mitochondria that has nothing to do with muscle. This episode rewrites what you thought you knew about longevity, anti-aging biology, and how your body actually produces and delivers energy at the cellular level. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR -Explore all of Wonderfeel's products at: getwonderfeel.com/dave They are gifting a complimentary 7-day Youngr™ supply (mini pouch) with every order across any of their products. The code will be DAVE, and the campaign will be active through June 6th. Host Dave Asprey sits down with Dr. Andrew Salzman, a physician, inventor, and biomedical entrepreneur with more than 30 years of experience in drug discovery and development. An alumnus of Harvard Medical School, Yale University, and Columbia University, Dr. Salzman has authored more than 170 scientific publications and holds 50 patents. He invented the original clinical-stage PARP-1 inhibitor, leading to the world's first clinical treatment for raising NAD levels and fighting cancers caused by the BRCA1 and BRCA2 genes. Genentech licensed his breakthrough technology for $600 million. His research into gastrointestinal microbiota, autoimmune disease, oxidative stress, and mitochondrial ATP production now forms the foundation of how millions of patients get treated worldwide. Dr. Salzman names the two biggest NAD drains in your body, CD38 and PARP, and explains why taking NMN or NR alone is like filling a bathtub with the drain wide open. He breaks down the formulation science behind pairing NAD precursors with CD38 blockers like hydroxytyrosol alongside PARP-reducing antioxidants like ergothioneine, and delivers a paradigm-shifting explanation of creatine as an energy distribution network inside your cells. Rather than a simple muscle supplement, creatine acts as a high-speed ATP shuttle that carries energy from your mitochondria to the precise location and moment your brain, gut, and heart need it most. You'll Learn: Why NAD declines with age and which two enzymes are primarily responsible for draining it How CD38 rises with inflammation rather than NAD levels, and what that means for your supplement strategy Why creatine is one of the most underrated anti-aging and brain optimization supplements available How creatine functions as a spatial and temporal energy delivery network for your brain, gut, and heart Why the gut may be the origin point of the entire aging process and how that cascade unfolds decade by decade How leaky gut drives systemic inflammation, crashes NAD, and accelerates biological aging throughout the body What controls tight junction integrity and how ATP, butyrate, creatine, and fasting all play a role Why most creatine supplements fail to absorb properly and what to look for in a high-quality source How to rebuild your microbiome in three to four weeks through diet alone, without antibiotics Why walking immediately after a meal may be doing more harm than good to your gut lining Thank you to our sponsors! - Screenfit | Get your at-home eye training program for 40% off using code DAVE at https://www.screenfit.com/dave. - KILLSwitch | If you're ready for the best sleep of your life, order now at https://www.switchsupplements.com/and use code DAVE for 20% off - Pique | Go to Piquelife.com/dave for 20% off. - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Dr. Andrew Salzman, NAD depletion, CD38 inhibition, PARP inhibition, NMN supplements, creatine ATP shuttle, leaky gut aging, tight junction integrity, inflammaging, lipopolysaccharide gut, flagellin toxin, butyrate gut healing, ergothioneine, hydroxytyrosol, peroxynitrite, superoxide mitochondria, creatine energy distribution, gut origin of aging, NAD bathtub analogy, BRCA PARP inhibitor, Wonderfeel, creatine monohydrate, intestinal permeability, microbiome butyrate, selective digestive decontamination, TMAO nitric oxide Resources: • Explore all of Wonderfeel's products at: getwonderfeel.com/dave • Order Youngr™: getwonderfeel.com/dave• Order ChocoCreatin™: getwonderfeel.com/dave• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 01:12 – Introduction & BRCA Background 02:19 – DNA Damage & PARP 04:38 – Free Radicals & Oxidative Stress 11:37 – NAD & Antioxidant Defense 12:34 – CD38 & NAD Depletion 23:31 – The Gut-Aging Hypothesis 30:05 – ATP, Creatine & Energy Distribution 36:41 – Creatine as Energy Shuttle 51:09 – Microbiome & Gut Repair 59:21 – TMAO & Nitric Oxide Interference 1:03:52 – Flagellin & Gut Inflammation Research 1:09:45 – FDA & Pharmaceutical Incentives 1:16:05 – Closing See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Longevity Science Explained: Mitochondria, DNA Damage, Senescent Cells & Peptides with Greg MacphersonHost Vicki Nguyen introduces One Body, One Life, a longevity-focused show sponsored by Jomei's Fine Foods, and interviews Greg Macpherson, a New Zealand pharmacist and founder of SRW Laboratories. Greg shares how working with residential care patients and discovering “The Hallmarks of Aging” shaped his focus on healthspan versus lifespan, using a Mount Everest analogy and noting healthspan is typically about 10 years shorter than lifespan. He highlights key drivers of aging including DNA damage (with lifestyle strategies like “sunscreen for your cells”), personal viral burden and immune fatigue (including attention to absolute lymphocyte count), mitochondrial decline and targeted antioxidants like mitoquinol, and chronic inflammation linked to oxidative stress. They discuss cellular senescence, fasting, time-restricted eating, exercise, and compounds like fisetin and quercetin, plus emerging areas like stem cells, peptides, biological age testing via DNA methylation, and future cellular “reprogramming,” along with Greg's top lifestyle practices and where to find him (srw.co).

What if the single device you hold closest to your body for 10+ hours a day is quietly rewriting your biology — and your grandchildren's?In this episode of Health Longevity Secrets, Robert Lufkin MD sits down with Daniel DeBaun — a former Bell Labs and AT&T telecom engineer who helped build the very wireless standards the industry still runs on, then walked away to warn us about them. He is the founder and CEO of DefenderShield and co-author of "Radiation Nation," and he pulls back the curtain on what 4G, 5G and the coming 6G are actually doing to the human body, the gut microbiome, fertility, and the developing child.CHAPTERS:00:00 — Introduction02:18 — Daniel's Bell Labs Origin Story03:36 — The Laptop Incident That Changed Everything05:51 — EMF 101: What You Need to Know08:36 — Ionizing vs Non-Ionizing Radiation11:53 — Blue Light and Eye Damage17:46 — Why 5G and 6G Are Different18:41 — The Gut Microbiome RF Connection20:47 — DNA Damage and Calcium Channels21:43 — The Electro-Hypersensitivity Epidemic25:12 — Frontal Lobe Cancer in Heavy Phone Users27:34 — Big Tech Ignores These Animal Studies32:55 — Will My Cellphone Kill Me?34:56 — Outdated FCC Standards From 199036:16 — RFK Jr. Won His FCC Lawsuit37:58 — DefenderShield and How Shielding Works39:41 — Why Kids Are Most at Risk45:05 — Where to Learn More47:14 — Final Takeaway: You Are the ArchitectKEY TAKEAWAYS:• Heavy cellphone users (1+ hrs/day for 10+ years) face up to 3× the risk of frontal-lobe cancer• Non-ionizing EMFs damage cells through calcium-channel disruption, not just heat• The gut microbiome is directly altered by radio-frequency exposure• Up to 50% of people now report symptoms of electro-hypersensitivity (headaches, nausea, stress)• Current FCC safety standards were written in 1990 for a 6-foot male soldier — with the phone held 1 inch from the head• Simple home changes — wired internet, phone off the body, distance from routers — cut most exposureSTUDIES & SOURCES MENTIONED:• National Toxicology Program cell phone radiation study (2018) — "clear evidence" of heart tumors and DNA damage in rats• Ramazzini Institute base-station study (2018) — malignant heart schwannomas at non-thermal levels• Dr. Joel Moskowitz — SaferEMR• Dr. Devr⭐ Enjoying the show? Please leave a 5-star review on Apple Podcasts — it takes 30 seconds and helps more people discover the science of health and longevity. Thank you!New episodes every Tuesday & Thursday. Subscribe so you don't miss one.Continue this conversation on Substack: https://robertlufkinmd.substack.comLies I Taught In Medical School — Free sample chapter: https://www.robertlufkinmd.com/lies/Web: https://www.robertlufkinmd.comYouTube: https://www.youtube.com/robertlufkinmdX: https://x.com/robertlufkinmdInstagram: https://www.instagram.com/robertlufkinmd/TikTok: https://www.tiktok.com/@robertlufkinLinkedIn: https://www.linkedin.com/in/robertlufkinmd/

New research reveals that thirty days of exposure to twenty-six hundred megahertz electromagnetic fields -- the same frequency used by four G cell towers -- caused significant DNA damage in rat blood cells. Turkish researchers used the gold-standard comet assay to detect genetic damage after EMF exposure, finding clear evidence of DNA strand breaks even when organs appeared normal. This study adds to mounting evidence that cellular damage occurs before visible tissue effects become apparent. In This Episode How cell tower frequencies damage DNA at the cellular level Why the comet assay is considered the gold standard for genetic damage detection What this means for everyday exposure to wireless infrastructure Featured Study Read the full study: DNA Damage Analysis by Comet Assay Method in Blood Tissue and Physiopathological Evaluation of the Effect of Quercetin on Kidney Tissue in 2600 MHz Electromagnetic Field Exposure See all studies at shieldyourbody.com/research

From gut bacteria to enzyme mimicry, glyphosate dismantles biological systems—and lawsuits confirm the damage. #GlyphosateRisks #GutHealth #ToxicLegacy #HealthTalks

Miscarriage affects somewhere between 10 to 15 out of every 100 pregnancies, yet the male contribution to early pregnancy loss is rarely part of the clinical conversation. In this episode of the Fertility Friday Podcast, Lisa breaks down a 2021 study examining sperm DNA fragmentation as a biomarker for miscarriage — and what the findings may mean for practitioners supporting couples through fertility challenges.  Follow this link to view the full show notes page! This episode is sponsored by Lisa's new book Real Food for Fertility, co-authored with Lily Nichols! Grab your copy here!  Would you prefer to listen to the audiobook version of Real Food for Fertility instead?

Turkish researchers found that six months of daily cell phone radiation exposure caused measurable DNA damage in rat brain tissue -- at levels below current safety limits. In this episode, we examine groundbreaking research that exposed rats to three common cell phone frequencies for two hours daily over six months. The results reveal concerning effects on brain DNA and cellular health that challenge our understanding of "safe" exposure levels. In This Episode Why six-month exposure studies matter more than short-term research DNA damage found at all three cell phone frequencies tested What oxidative stress means for your brain health Featured Study Effect of 900-, 1800-, and 2100-MHz radiofrequency radiation on DNA and oxidative stress in brain Read the full study at shieldyourbody.com/research

Wireless tech wasn't tested for long-term safety. Learn how EMFs disrupt your biology and why “non-ionizing” doesn't mean harmless. #EMFHealth #WirelessRisks #CellRadiation #HealthTalks

If you've been told your failed IVF cycle was "just bad luck" or blamed on "egg quality," that explanation is incomplete. Bad luck is not a diagnosis. It simply means the underlying biological patterns have not yet been identified. IVF is a technical process that happens in a lab, but embryos still develop inside a living biological environment. If inflammation, energy production, immune signaling, or sperm DNA integrity are compromised, no protocol change alone can override that physiology. Repeating cycles without deeper interpretation often leads to the same outcomes, higher costs, and more emotional exhaustion. In this episode, I walk through the three biological patterns I consistently see behind embryo arrest, poor blast development, failed transfers, and unexplained IVF failure. More importantly, you'll learn how to use your past cycles as meaningful data so you can stop guessing and start making more strategic decisions before another round. In this episode, you'll learn: Why a technically "perfect" IVF cycle can still fail despite good labs and protocols How low cellular energy production impacts embryo development and early growth Why sperm DNA fragmentation often matters long before clinics flag it as abnormal How oxidative stress, inflammation, hormonal signaling, and metabolic strain influence embryo quality How to interpret repeated IVF outcomes instead of labeling them as unexplained or bad luck I'm Sarah Clark, founder of Fab Fertile and host of Get Pregnant Naturally. For over a decade, my team and I have reviewed hundreds of low AMH and failed IVF cases using functional testing alongside conventional fertility care. We specialize in helping couples identify the physiological patterns driving poor outcomes so decisions are grounded in interpretation, not guesswork. This episode is for you if: You've experienced embryo arrest, failed transfers, or repeated IVF cycles without clear answers You've been told everything looks "normal" but results keep falling short You want a smarter way to evaluate what your body is signaling before investing in another cycle

ReferencesGuerra, DJ.2025. Unpublished LecturesHepatology.2023 Apr 17;77(5):1654–1669Comprehensive Gut Microbiota2022, Pages 201-219Dylan, B. 1964. My Back Pages. Byrdshttps://music.youtube.com/watch?v=OADlrLHfYW4&si=Q63xZIE_33GXVYv4

ReferencesMol Immunol. 2017 Apr 1;87:1–11Guerra, DJ 2025 Unpublished LecturesHayward/Pinder/Lodge/Thomas. 1967. Days of Future Passed. Moody Blues.https://music.youtube.com/playlist?list=OLAK5uy_l2x8IxcSnnBm21QUI3aKwu7Sz8thfM-1w&si=9tsIhVrSdLrMn7vG

ReferencesGuerra, DJ.2025 Unpublished LecturesHepatology.2023 Feb 9;78(3):878–895.Mozart, WA. Mass in C Minor, K, 427https://music.youtube.com/watch?v=Ez0kqVShFEs&si=D1MUVoXZIbPxRyM4

ReferencesHepatology.2023 Feb 9;78(3):878–895.Mozart, WA. 1791. Ave Verum Corpus. K618https://music.youtube.com/watch?v=Z-xMjO0d-pc&si=g1TpOohQQt9forf0Murray, J. 1874 Jolly Old St Nicholas. Instrumentalhttps://music.youtube.com/watch?v=eTHdEA5zh2Q&si=0v0ADs7LhtIu7zqd

ReferencesPharmacological Reviews.2011.NOV.64(1):166-87Hepatology.2023 Feb 9;78(3):878–895.Sci Rep. 2015 Sep 30;5:14692Bach, JS. 1734. Christmas Oratories BV 248.https://music.youtube.com/watch?v=98UjjwzJBFE&si=kd45twdzgpXtJuWL

Most conversations about fertility focus on women. But here's the truth: up to 50% of infertility cases are male and men's reproductive health is a powerful window into their overall wellbeing, longevity, and disease risk.This week's guest, Professor Suks Minhas, world-leading consultant urologist and expert in male fertility is here to change how we think about men's health. With decades of clinical and research expertise, he reveals why sperm counts are falling, what it really says about men's health today, and the practical steps every man can take to protect his future.Together we explore: – Why male infertility makes up half of cases and why it's rarely discussed – The surprising links between sperm health, testosterone, and metabolic disease – DNA fragmentation: the overlooked cause of “unexplained infertility” – How lifestyle, stress, alcohol, and obesity directly affect fertility– The role of endocrine disruptors and environmental toxins in declining sperm quality – Fertility preservation: should men also consider freezing their sperm? – Testosterone replacement therapy (TRT): who it helps, who it harms, and why it can act as a male contraceptive – Actionable, evidence-based ways to optimise male fertility and long-term healthThis isn't just a conversation about reproduction. It's a wake-up call for men's health, fertility, and longevity. Whether you're thinking about children, or simply want to future-proof your health, this episode gives you the clarity to take action.Love,Sarah Ann

Dr. Hoffman continues his conversation with Dr. Aimie Apigian, author of “The Biology of Trauma: How the Body Holds Fear, Pain, and Overwhelm, and How to Heal It.”

Dr. Aimie Apigian, author of “The Biology of Trauma: How the Body Holds Fear, Pain, and Overwhelm, and How to Heal It,” details how unaddressed trauma is often the hidden cause of many preventable illnesses and is linked to eight of the ten leading causes of death. The conversation delves into the physiological responses to trauma, the mechanisms by which trauma can manifest in chronic physical ailments, and the importance of incorporating a holistic approach that includes addressing mental, somatic, and biological impacts of trauma. Dr. Apigian also shares insights from her personal journey and professional evolution, emphasizing the need for a combination of medical treatment and trauma work for optimal health.

Ask a question on our Youtube Channel: https://www.youtube.com/@GenerativeAIMeetup Mark's Travel Vlog: https://www.youtube.com/@kumajourney11 Mark's Personal Youtube Channel: https://www.youtube.com/@markkuczmarski896 Attend a live event: https://genaimeetup.com/ Shashank Linked In: https://www.linkedin.com/in/shashu10/    In this episode of the Generative AI Meetup Podcast, hosts Shashank and Mark dive into the latest breakthroughs in AI and technology. Fresh from his adventures across North America, Mark joins Shashank to discuss OpenAI's groundbreaking GPT-4B advancements in biology and medicine, including AI-driven cell reprogramming for potential longevity breakthroughs. They also cover Meta's newly announced Ray-Ban smart glasses with heads-up displays and gesture controls, Apple's iPhone 17 AI features like real-time translation and transcription (and how they stack up against Google's Pixel phones), massive funding for Figure AI's humanoid robots, Tesla's Optimus updates, and Waymo's expansion to San Francisco International Airport. Plus, insights on the US-China robotics race, upcoming coding agents meetups during Tech Week, and the future of consumer AI hardware. Tune in for an engaging mix of news, analysis, and excitement about AI's real-world impact! Mark Linked in: https://www.linkedin.com/in/markkuczmarski/ 

When Brandon and Whitney Cawood's three-year-old son was expelled from daycare for aggressive behavior, they faced a crossroads that would change not only their lives but potentially millions of others. Rather than accepting the psychiatric diagnoses being pushed on them, they discovered something shocking: their son's severe behavioral issues weren't psychological at all—they were chemical reactions to synthetic food dyes hiding in his daily allergy medication and antibiotics.Within 48 hours of removing these petroleum-based chemicals from his diet, they met their real son for the first time. This revelation launched them on a journey that would lead to creating the documentary "To Dye For," building a community of nearly one million parents, and influencing legislation across multiple states.To Dye For Documentary Dr. Roger McFillin / Radically Genuine WebsiteYouTube @RadicallyGenuineDr. Roger McFillin (@DrMcFillin) / XSubstack | Radically Genuine | Dr. Roger McFillinInstagram @radicallygenuineContact Radically GenuineConscious Clinician CollectivePLEASE SUPPORT OUR PARTNERS15% Off Pure Spectrum CBD (Code: RadicallyGenuine)10% off Lovetuner click here

TAKEAWAYSRadiation and wireless technology thwarts the natural processes of the brainRed blood cells can become deformed, and tissue damage can occur after exposure to radiationPeople should use wired devices to avoid wireless damage to the brain and body and keep in flight mode as much as possiblePlans for 5G are to release devices up to 90 gigahertz and involves the densification of 4G that penetrates the body deeper

“Hell is empty, all the devils are here.” – William Shakespeare My question remains, WHY does USA has 92 Nuclear Plants, China 55, Russia 37, Japan 33, South Korea 25, India 22, Ukraine 15, IRAN HAS ONE. Psychopath In Your Life Plutonium: Rocky Flats Anatomy of Disaster. USA has 92 Nuclear, China 55, Russia 37, […] The post Fluoride AND Plutonium = BOTH are EQUALLY Dangerous to Health and CREATE Cancer.  Is this the ROOT cause of Cancer and Sugar is the match that lights the fire?  IRAQ and DNA Damage. appeared first on Psychopath In Your Life.

Dr. Hoffman continues his conversation with Dr. Kieran Murphy, author of “The Essence of Invention: Medicine and the Joy of Creativity,”

In this episode of the Intelligent Medicine podcast, Dr. Ronald Hoffman interviews Professor Kieran Murphy, an interventional neuro radiologist and prolific inventor from Toronto Western Hospital. Dr. Murphy has developed numerous innovative medical devices and filed 60 patents. He shares insights from his book, “The Essence of Invention: Medicine and the Joy of Creativity,” discussing his work on medical innovation, his unique background, and personal experiences that have driven his creative solutions. The conversation covers various topics, including the importance of creativity, the impact of bureaucracy on modern medicine, and groundbreaking innovations like ozone therapy for herniated discs and a radio-protective supplement for medical personnel. Dr. Murphy emphasizes mindfulness and paying attention to phenomena as key components for fostering creativity and innovation in medicine.

Theodora Scarato discusses the potential health risks associated with 5G, cell phones, and cell towers. Learn practical steps to protect yourself and maintain your well-being in a connected world. #5GHealthRisks #ElectromagneticSafety #HealthProtection

Immune explores the immunological diversity in the upper airway, including memory B and T cells and germinal center B cells, and how chronic infection with Plasmodium parasites leads to development of B cell cancers. Hosts: Vincent Racaniello, Cindy Leifer, Steph Langel, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Immune memory diversity in human upper airway (Nature) How Plasmodium infection promotes B cell cancers (Cell) Time stamps by Jolene. Thanks! Music by Tatami. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Originally recorded in 2022, this episode features Dr. Lauren Trepanier from the University of Wisconsin, revealing her groundbreaking research into the link between environmental pollution and dog cancer. Key Topics: Environmental Pollutants and Cancer in Dogs: Dr. Trepanier's research links pollutants such as ozone, benzene, trichloroethylene, and herbicides to cancer in dogs. Lymphoma Study: Ongoing studies on Boxers and Golden Retrievers with lymphoma aim to determine how air pollutants, including ozone and VOCs, may trigger cancer. Bladder Cancer Study: The research also investigates dogs with bladder cancer, focusing on household pollutants like arsenic and acrolein, which are linked to bladder cancer in humans. Human-Dog Connection: Dr. Trepanier explains how dogs' cancer risks from pollutants can also provide insight into potential cancer risks for humans. One Health Initiative: The episode discusses how the One Health initiative encourages collaboration between veterinary and human medical professionals to advance research and treatment. Practical Applications: Dr. Trepanier offers suggestions on how dog owners can mitigate cancer risks, including reducing exposure to VOCs and herbicides. Links and Resources: Dog Cancer Survival Guide by Dr. Demian Dressler and Dr. Susan Ettinger Morris Animal Foundation's Golden Retriever Lifetime Study AKC Canine Health Foundation One Health Alliance Canine Health Foundation Golden Retriever Lifetime Study Boxer Lymphoma Study Recruitment Flier Transitional Cell Carcinoma Study Recruitment Flier Your Voice Matters! If you have a question for our team, or if you want to share your own hopeful dog cancer story, we want to hear from you! Go to https://www.dogcancer.com/ask to submit your question or story, or call our Listener Line at +1 808-868-3200 to leave a question. Related Videos:            A fantastic interview with Dr. Janet Patterson-Kane of Morris Animal Foundation: https://www.youtube.com/watch?v=WEvFhsC_TyY Related Links: Our article on Pollution and other Environmental cancer causes: https://www.dogcancer.com/articles/causes-and-prevention/pollution/ Learn about pharmaceuticals in the drinking water: https://www.dogcancer.com/articles/causes-and-prevention/pharmaceuticals-in-drinking-water/ Our article on Bladder Cancer: https://www.dogcancer.com/articles/types-of-dog-cancer/bladder-cancer-in-dogs-including-transitional-cell-carcinoma/ Our article on Lymphoma: https://www.dogcancer.com/articles/types-of-dog-cancer/lymphoma-in-dogs/ Chapters: 00:00 - Introduction 00:45 - Environmental Toxins and Cancer in Dogs 01:30 - Ozone and Air Pollution's Link to Cancer 03:00 - Fracking and Cancer Risks in Dogs 03:45 - Measuring VOCs in Dogs 05:00 - Chemical Testing in Homes 06:00 - Household Chemicals and Human Studies 07:00 - Bladder Cancer and Household Exposures 09:00 - DNA Damage in Dogs and Owners 10:00 - Bladder Cancer as a Warning Sign 11:30 - How Did My Dog Get Cancer? 12:15 - Practical Steps to Reduce Cancer Risk 13:30 - Chemical Damage After Diagnosis 14:00 - Environmental Concerns from the Dog Cancer Survival Guide 15:15 - Dr. Trepanier's Background and Expertise 16:30 - Research and Time for Discoveries 17:30 - One Health Initiative Explained 19:00 - Veterinarians as Key Researchers in Cancer 20:30 - Recruiting Dogs for Cancer Studies 22:00 - Collaboration with the Golden Retriever Lifetime Study 24:00 - The Importance of Reaching Diverse Communities 26:00 - How Listeners Can Get Involved 28:00 - Generosity of Dog Lovers 29:30 - Dr. Trepanier's Personal Connection Dog Cancer Story 30:00 - Outro and Resources Get to know Dr. Lauren Trepanier: https://www.dogcancer.com/people/lauren-trepanier-dvm-phd-dacvcp-dacvim-saim/ For more details, articles, podcast episodes, and quality education go to the episode page: https://www.dogcancer.com/podcast/ Learn more about your ad choices. Visit megaphone.fm/adchoices

Oren Gilad, President and CEO of Aprea Therapeutics, focused on the DNA damage response pathway, specifically targeting the ATR protein. ATR is a master regulator of DNA replication and is hyperactive in cancer cells, making it a potential Achilles heel for cancer therapy. By inhibiting ATR, cancer cells can be selectively targeted, while normal cells can tolerate lower levels of ATR activity. Synthetic lethality is applied when two genetic mutations are combined, leading to cell death, specifically in cancer cells. Aprea is conducting clinical trials for their targeted treatments, focusing on solid tumors with defined genetic mutations. Oren explains, "DDR, the DNA damage response pathway, is the broader terminology for the regulation of DNA synthesis. In order for cancer to grow, cells have to duplicate. In order for them to duplicate, they have to replicate their DNA. So what happens is that cancer cells get into this DNA replication phase very early and prematurely, causing a single-strand DNA to be exposed which then activates the ATR pathway, where in normal cells, this pathway is very tightly regulated. The normal cell is not going to enter this phase and start DNA replication before the environment is ready because it's a very fragile phase of the cell cycle." "Double-strand DNA is a very stable molecule. It is found in mummies, it survives heat, and it survives freezing. When a double-strand DNA molecule is opened, the exposed single-strand DNA can easily break. That's where ATR comes into play, it protects and responds to single-strand formation. A cancer cell is hyper-sensitive to ATR inhibition, which we identify as the Achilles heel of cancer. Our work showed that normal cells can live with a reduced level of the ATR activity, so it makes it a good target for cancer therapy." #ApreaTherapeutics #CancerTreatment #TargetedTherapy #Oncology #Cancer #SyntheticLethality #DNADamageResponsePathway aprea.com Download the transcript here

Oren Gilad, President and CEO of Aprea Therapeutics, focused on the DNA damage response pathway, specifically targeting the ATR protein. ATR is a master regulator of DNA replication and is hyperactive in cancer cells, making it a potential Achilles heel for cancer therapy. By inhibiting ATR, cancer cells can be selectively targeted, while normal cells can tolerate lower levels of ATR activity. Synthetic lethality is applied when two genetic mutations are combined, leading to cell death, specifically in cancer cells. Aprea is conducting clinical trials for their targeted treatments, focusing on solid tumors with defined genetic mutations. Oren explains, "DDR, the DNA damage response pathway, is the broader terminology for the regulation of DNA synthesis. In order for cancer to grow, cells have to duplicate. In order for them to duplicate, they have to replicate their DNA. So what happens is that cancer cells get into this DNA replication phase very early and prematurely, causing a single-strand DNA to be exposed which then activates the ATR pathway, where in normal cells, this pathway is very tightly regulated. The normal cell is not going to enter this phase and start DNA replication before the environment is ready because it's a very fragile phase of the cell cycle." "Double-strand DNA is a very stable molecule. It is found in mummies, it survives heat, and it survives freezing. When a double-strand DNA molecule is opened, the exposed single-strand DNA can easily break. That's where ATR comes into play, it protects and responds to single-strand formation. A cancer cell is hyper-sensitive to ATR inhibition, which we identify as the Achilles heel of cancer. Our work showed that normal cells can live with a reduced level of the ATR activity, so it makes it a good target for cancer therapy." #ApreaTherapeutics #CancerTreatment #TargetedTherapy #Oncology #Cancer #SyntheticLethality #DNADamageResponsePathway aprea.com Listen to the podcast here

Subscribe to our channel: https://www.youtube.com/@optispan Check out the Gurkar lab: http://agresearchlab.com/ In May 2024, Matt delivered a talk at the 2024 Glenn AFAR Grantee Conference in Santa Barbara, California and met with several people doing interesting work in the longevity field. One of these was Aditi Gurkar, an assistant professor in the University of Pittsburgh's Aging Institute, Division of Geriatric Medicine whose lab focuses on the downstream effects of DNA damage on aging. Prior to setting up her lab at the University of Pittsburgh, Aditi conducted research on the impact of DNA damage on aging at Scripps Research. She also completed postdoctoral training at Massachusetts General Hospital/Harvard Medical School and the Broad Institute of MIT and Harvard, where she focused on the tumor suppressor p53 as well as on autophagy regulation. Aditi received a PhD and a B.S. from the Boston University School of Medicine and Florida International University in Miami respectively. Matt and Aditi spend much of this episode chatting about senescent cells: how Aditi developed a focus on cellular senescence and found its relevance to aging, potential therapeutic benefits of senescent cell clearance, and the much-debated question of how to define a senescent cell. They also discuss the importance of "zooming out" from narrow areas of focus in the geroscience field to find new solutions and of breaking your own models on your way to productive new directions in science. Producers: Tara Mei, Nicholas Arapis Video Editor: Jacob Keliikoa DISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices. More places to find us: Twitter: https://twitter.com/optispanpodcast Twitter: https://twitter.com/optispan Twitter: https://twitter.com/mkaeberlein Linkedin: https://www.linkedin.com/company/optispan https://www.optispan.life/ Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it. On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!

BUFFALO, NY- June 26, 2024 – A new research perspective was published in Oncotarget's Volume 15 on June 20, 2024, entitled, “Starving cancer cells to enhance DNA damage and immunotherapy response.” Prostate cancer (PCa) poses significant challenges in treatment, particularly when it progresses to a metastatic, castrate-resistant state. Conventional therapies, including chemotherapy, radiotherapy, and hormonal treatments, often fail due to toxicities, off-target effects, and acquired resistance. In this new research perspective, researchers Aashirwad Shahi and Dawit Kidane from Howard University define an alternative therapeutic strategy focusing on the metabolic vulnerabilities of PCa cells, specifically their reliance on non-essential amino acids such as cysteine. “In this prospective, we will rise the driving questions and potential possibilities how amino acid depletion induced oxidative stress associated DNA damage exploited for DNA repair targeted and immune checkpoint blockade therapy [...].” Using an engineered enzyme cyst(e)inase to deplete the cysteine/cystine can induce oxidative stress and DNA damage in cancer cells. This depletion elevates reactive oxygen species (ROS) levels, disrupts glutathione synthesis, and enhances DNA damage, leading to cancer cell death. The combinatorial use of cyst(e)inase with agents targeting antioxidant defenses, such as thioredoxins, further amplifies ROS accumulation and cytotoxicity in PCa cells. “Overall, this perspective provides a compressive overview of the previous work on manipulating amino acid metabolism and redox balance modulate the efficacy of DNA repair-targeted and immune checkpoint blockade therapies in prostate cancer.” DOI - https://doi.org/10.18632/oncotarget.28595 Correspondence to - Dawit Kidane - dawit.kidane-mulat@howard.edu Video short - https://www.youtube.com/watch?v=Zrj24o_-b50 Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28595 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, amino acid depletion, DNA damage, DNA repair, Immunotherapy, tumor immunity About Oncotarget Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. Oncotarget is indexed and archived by PubMed/Medline, PubMed Central, Scopus, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science). To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957

What can worms teach us about carcinogen exposure or chemotherapy? Sophia Tintori, postdoctoral associate in the biology department at New York University, heads to Chornobyl to find out. Sophia Tintori is a postdoctoral associate in the Biology Department at New York University. She was trained in developmental biology, cell biology, and genetics at Brown University […]

The Wyrd Mountain Gals Show "Breakfast Candy  Part 2" Episode Airs Sunday, 5-19-24     7pm Episode Link Here: https://www.podbean.com/eas/pb-jb2xp-1617cc0 Alicia thinks this is the "20 Confessionss" episode.     Byron is taking her vitamins on this sunny/breezy morning.  Alicia just figured out that her computer has a touch screen (duh!).    "The bloom is off the rose":  The person, object, or situation identified in the context has lost its novelty, freshness, appeal, or acceptability "When the frost is on the punkin..":  The saying comes from a 19th century poem written by James Whitcomb Riley titled “When the Frost is on the Pumpkin”, which referred to when it was time to reap the autumn harvest Darmok (episode): https://memory-alpha.fandom.com/wiki/Darmok_(episode) Long vax:  https://www.medpagetoday.com/neur.../generalneurology/107644 Effects of COVID-19 Disease on DNA Damage, Oxidative Stress and Immune Responses:  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145820/ Fantastic Fungi:  https://fantasticfungi.com/     #WyrdMountainGals #ByronBallard #Appalachia #DigitalWitchery

The Wyrd Mountain Gals Show "Breakfast Candy" Episode Airs Sunday, 5-12-24     7pm Episode Link Here:  https://www.podbean.com/eas/pb-gqs3a-160d79c Byron is taking her vitamins on this sunny/breezy morning.  Alicia just figured out that her computer has a touch screen (duh!).   "The bloom is off the rose":  The person, object, or situation identified in the context has lost its novelty, freshness, appeal, or acceptability "When the frost is on the punkin..":  The saying comes from a 19th century poem written by James Whitcomb Riley titled “When the Frost is on the Pumpkin”, which referred to when it was time to reap the autumn harvest Darmok (episode): https://memory-alpha.fandom.com/wiki/Darmok_(episode) Long vax:  https://www.medpagetoday.com/neurology/generalneurology/107644 Effects of COVID-19 Disease on DNA Damage, Oxidative Stress and Immune Responses:  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145820/ Fantastic Fungi:  https://fantasticfungi.com/       #WyrdMountainGals #ByronBallard #Appalachia #DigitalWitchery

In this episode of Longevity by Design, host Dr. Gil Blander is joined by Dr. Morten Scheibye-Knudsen, a leading figure in aging research. Dr. Scheibye-Knudsen discusses his groundbreaking research on the role of DNA damage in the aging process and its implications for chronic diseases, aging research, and longevity medicine. The goal of his work is "to discover interventions leading to healthier, happier, and more productive lives."Dr. Scheibye-Knudsen's work is on understanding normal and premature aging, with a focus on the pivotal role of DNA damage in the aging process and interventions for healthier aging. By combining computational methods with laboratory experiments, his team explores innovative strategies to target DNA and counteract aging processes. This conversation illuminates the intricate relationship between DNA damage, aging, and chronic diseases. Dr. Scheibye-Knudsen also discusses the impact of lifestyle (diet, exercise, sleep, social factors) on aging. He goes on to describe his work using data-driven approaches to better understand aging and developing interventions, including identifying novel targets and drugs, for healthier aging. Additionally, he explains what longevity medicine is and the importance of educating clinicians and politicians on this topic to translate research on aging into healthcare and improve people's healthspan and lifespan. Dr. Scheibye-Knudsen's dedication to unraveling the mysteries of aging is advancing scientific knowledge, which has tangible benefits for global health and longevity.Episode timestampsIntroduction: 00:00-03:06What led Dr. Morten Scheibye-Knudsen to become a scientist?: 03:07-04:37Could please give us an overview of the research you are doing?: 04:38-05:54What is DNA damage, and what causes it?: 05:55-07:54What do we know about the influence of DNA damage on aging and age-related diseases?: 07:55-09:41Can DNA damage be repaired? 09:42-14:14What questions are your research group asking to better understand DNA damage and repair and their effects on aging?: 14:15-16:22What is NAD, and why is it relevant to aging and age-related diseases?: 16:23-19:56What are the benefits and risks of NR and NMN supplements in humans?: 19:57-24:50What is a ketogenic diet? What are the effects of a ketogenic diet or ketones on DNA damage or repair and aging?: 24:51-31:08What is the effect of a ketogenic diet on cancer?: 31:09-32:29What is the Aging Research and Drug Discovery (ARDD) conference and its mission?: 32:30-40:43What are the most prevalent features of aging?: 40:44-47:54Are there differences in aging between females and males?: 47:55-50:21Are there differences in tissue aging trajectories?: 50:22-54:01Identifying compounds that target aging: 54:02-56:16Can nuclear morphology predict cellular senescence and cancer?: 56:17-01:04:04What is longevity medicine, and why is it so important for physicians?: 01:04:05-01:07:25What pharmaceutical drugs are the most promising for targeting aging to extend human healthspan and lifespan?: 01:07:26-01:12:00How important are lifestyle factors such as nutrition, physical activity and exercise, sleep, and social engagement and connections for human healthspan and lifespan?: 01:12:01-01:16:39Dr. Morten Scheibye-Knudsen's top tip for health: 01:16:40-01:18:22

In this episode, we are sharing highlights from our webinar, ‘Mental Health and Wellbeing' with Michelle Overton. Michelle is a qualified counsellor and Mental Health First Aid Instructor Trainer. She discusses the impact of life's challenges on your mental health, coping mechanisms for stress and her top self-care tips. You can watch the original webinar here. Keep reading for the key episode takeaways. Topics and Timestamps: 01:03 Michelle shares her own mental health journey. 06:05 How does mental health shape your self-esteem and confidence? 08:27 The impact of life's challenges on your mental wellbeing. 11:00 Stress and how it can affect your DNA. 13:53 Shifting from unhealthy to healthy coping mechanisms. 19:14 Michelle's top self-care tips for improving your mental health. 24:02 The power of listening. 25:46 How you can find ways to improve sleep and mindful practices. Selected Key Takeaways: Mental health impacts many aspects of life. 07:01 “Confidence can be gauged in new situations [by] learning new skills [or] it could be in a workplace. Self-esteem is how you value yourself on the inside. Our mental health will govern how we feel, how we think, how we behave and how we manage change. It will [also] govern how we make, sustain and end relationships.” Stress can impact our physical health.   10:35 “After you've been experiencing stress for more than two weeks, your body will start to kick out hormones. Your double helix is your DNA and at the bottom of it, you've got the bottom of your shoelace strings that keep it together at the bottom, when the hormones are being kicked out from the stress, what happens is the shoe lay strings get corroded, and it comes undone. And this is when we start to get rogue DNA going around. And that's why it's been linked to being carcinogenic." Find what works for you and your mental health.   25:52 “It's finding what's right for you. I find talking has been a really helpful space for me, whether that's in therapy, or whether it's support services. Making sure that you're hydrated as well. Water can be a very simple thing that can really help instantly.” Want to learn more about living a full and happy life with multiple sclerosis? Sign up to our newsletter to hear our latest tips. More info and links: Watch the original webinar 5 Ways to Wellbeing from Mind Follow Michelle on social media on LinkedIn or Instagram Read Michelle's bio Study: Effects on DNA Damage and/or Repair Processes as Biological Mechanisms Linking Psychological Stress to Cancer Risk New to Overcoming MS? Visit our introductory page  Join a Circle and connect with others following Overcoming MS on the Live Well Hub Visit the Overcoming MS website Follow us on social media: Facebook Instagram YouTube Pinterest Don't miss out:  Subscribe to this podcast and never miss an episode. Listen to our archive of Living Well with MS episodes here. If you like Living Well with MS, please leave a 5-star review. Feel free to share your comments and suggestions for future guests and episode topics by emailing podcast@overcomingms.org. Make sure you sign up to our newsletter to hear our latest tips and news about living a full and happy life with MS. Support us:  If you enjoy this podcast and want to support the ongoing work of Overcoming MS, we would really appreciate it if you could leave a donation here. Every donation, however small, helps us to share the podcast with more people on how to live well with MS.

DNA Damage to the Human Race, Cancer Rates, Blood Clots, Myocarditis etc. Dr. Ryan Cole, Ed Dowd, Dr. Peter McCullough Overwhelming Evidence the Jab Poisoned the World The Ben Armstrong Show  Jan 16 2024   Other Episodes Top Experts prove beyond any doubt the jab is not safe for human use. DNA damage to the human race is a major concern as well. Dr. Peter McCullough Clip Ed Dowd Clip Dr. Ryan Cole. Blood Clotting. Amyloid protein Clots. Video Sources: 1. Bannon's War Room – Rep. Marjorie Taylor Greene Leads a Hearing on Injuries Caused By COVID-19 Vaccines: Part II 2. YEN VY CHANNEL – Tucker Carlson Tonight 1/15/24 | Tucker Carlson January 15, 2024   For all of Ben Armstrong's shows visit- https://thenewamerican.com/author/barmstrong/     Cancer Rates Are SOARING — WHY?! Steve Deace Show  Jan 18 2024   Other Episodes Steve discusses the American Cancer Society's cancer projections for 2024 and says there's only one explanation.

TODAY ON THE ROBERT SCOTT BELL SHOW: Medical Freedom resolutions, 70% Healthy Americans, Glyphosate DNA damage, Vibrating weight loss pill, Detox Dialogs - Dry Brushing, Militarys mandate push-back, Soil microbiome, Silver Aloe Protocol, Electrocultre, Airplane travel tips, Homeopathic Hits - Symphytum and MORE! http://www.robertscottbell.com/natural-remedies/medical-freedom-resolutions-70-healthy-americans-glyphosate-dna-damage-vibrating-weight-loss-pill-detox-dialogs-dry-brushing-militarys-mandate-push-back-soil-microbiome-silver-aloe-protocol/

Episode #280. Ever wondered how the simple act of timing – when you eat, sleep, or even look at your phone – could dramatically affect your health? In this episode, I sit down with circadian biology expert Dr Satchin Panda to explore this concept. We delve into the science of our body's internal clocks and offer practical advice to keep them in sync. Don't miss out on unlocking the potential of your circadian rhythm for a healthier, more balanced life. We discuss: Introduction (0:00) Understanding Circadian Rhythms: Do They Influence Longevity? (1:55) The Role of the Suprachiasmatic Nucleus (SCN) in Circadian Rhythms (6:20) Cellular-Level Circadian Clocks: An Overview (10:33) A Comprehensive Look at Circadian Disruption (15:56) Effective Strategies for Managing Jet Lag (26:39) The Impact of Blue Light on Circadian Rhythms (29:17) Criteria for Diagnosing Circadian Rhythm Disorders (33:42) Sensitivity Factors of Circadian Rhythms (34:58) The Significance of Meal Timing in Circadian Rhythms (39:30) Circadian Rhythms: Their Relation to Cholesterol and Blood Pressure (43:41) Exploring the Link Between Circadian Disruption, DNA Damage, and Cancer Risk (46:49) Circadian Disruption and Its Role in Chronic Disease Risk (49:34) Time-Restricted Eating and Metabolic Health (55:22) Outro (1:06:09) To connect with Dr Satchin Panda, you can find him on Twitter and read his peer-reviewed papers on his profile. To learn more about circadian biology, his books, The Circadian Code and The Circadian Diabetes Code, are an incredible resource. You can also better understand your circadian rhythm while contributing to research with Dr Panda's app, myCircadianClock. Optimise your health with InsideTracker's biomarker analysis. Get exclusive access to InsideTracker's new ApoB test, and a significant discount at insidetracker.com/simon. Enjoy, friends. Simon Want to support the show? The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family. Simon Hill, MSc, BSc (Hons) Creator of theproof.com and host of The Proof with Simon Hill Author of The Proof is in the Plants Watch the episodes on YouTube or listen on Apple/Spotify Connect with me on Instagram, Twitter, and Facebook Nourish your gut with my Plant-Based Ferments Guide Download my complimentary Two-Week Meal Plan and high protein Plant Performance recipe book

In this episode of the Epigenetics Podcast, we caught up with Björn Schumacher from the Institute for Genome Stability in Ageing and Disease at the University of Cologne to talk about his work on DNA damage in longevity and ageing. In this episode Björn Schumacher discusses his research on DNA repair and its impact on ageing. We explore his insights on the effects of DNA damage on transcription, the importance of studying development, and the role of histone modifications. We also discuss paternal DNA damage inheritance and the DREAM complex as a master regulator of DNA repair. The lab's goal is to enhance somatic DNA repair for healthier ageing and disease prevention.   References Schumacher, B., van der Pluijm, I., Moorhouse, M. J., Kosteas, T., Robinson, A. R., Suh, Y., Breit, T. M., van Steeg, H., Niedernhofer, L. J., van Ijcken, W., Bartke, A., Spindler, S. R., Hoeijmakers, J. H., van der Horst, G. T., & Garinis, G. A. (2008). Delayed and accelerated aging share common longevity assurance mechanisms. PLoS genetics, 4(8), e1000161. https://doi.org/10.1371/journal.pgen.1000161 Ermolaeva, M. A., Segref, A., Dakhovnik, A., Ou, H. L., Schneider, J. I., Utermöhlen, O., Hoppe, T., & Schumacher, B. (2013). DNA damage in germ cells induces an innate immune response that triggers systemic stress resistance. Nature, 501(7467), 416–420. https://doi.org/10.1038/nature12452 Wang, S., Meyer, D. H., & Schumacher, B. (2023). Inheritance of paternal DNA damage by histone-mediated repair restriction. Nature, 613(7943), 365–374. https://doi.org/10.1038/s41586-022-05544-w Bujarrabal-Dueso, A., Sendtner, G., Meyer, D. H., Chatzinikolaou, G., Stratigi, K., Garinis, G. A., & Schumacher, B. (2023). The DREAM complex functions as conserved master regulator of somatic DNA-repair capacities. Nature structural & molecular biology, 30(4), 475–488. https://doi.org/10.1038/s41594-023-00942-8   Related Episodes Effects of Environmental Cues on the Epigenome and Longevity (Paul Shiels) Transposable Elements in Gene Regulation and Evolution (Marco Trizzino) Epigenetic Clocks and Biomarkers of Ageing (Morgan Levine)   Contact Epigenetics Podcast on Twitter Epigenetics Podcast on Instagram Epigenetics Podcast on Mastodon Active Motif on Twitter Active Motif on LinkedIn Email: podcast@activemotif.com

UV nail dryers cause DNA damage - with Dr. Julia Curtis! Cantharidin 0.7% for Molluscum - Imiquimod 5% cream for LM - TNF inhibitor induced Psoriasis - Memantine for Trichotillomania & Skin Picking - Check out our video content on YouTube: ⁠Dermasphere Podcast - YouTube⁠ - and VuMedi!: https://www.vumedi.com/channel/dermasphere/ The University of Utah's Dermatology ECHO: ⁠⁠https://physicians.utah.edu/echo/dermatology-primarycare - ⁠⁠Connect with us! - Web: ⁠https://dermaspherepodcast.com/⁠ - Twitter: @DermaspherePC - Instagram: dermaspherepodcast - Facebook: https://www.facebook.com/DermaspherePodcast/ - Check out Luke and Michelle's other podcast, SkinCast! ⁠https://healthcare.utah.edu/dermatology/skincast/⁠ Luke and Michelle report no significant conflicts of interest… BUT check out our friends at: - ⁠Kikoxp.com ⁠(a social platform for doctors to share knowledge) - ⁠https://www.levelex.com/games/top-derm⁠ (A free dermatology game to learn more dermatology!)

Folks, on this week's episode we hear about a mysterious god orb from the ocean, how NASA may have accidentally killed some Martians years ago, vandals breaking through the great wall of China, NYC rat tours, and caffeine instant ramen for gamers Become a patron for weekly bonus eps and more stuff!: www.patreon.com/whatatimepod Check out our YouTube channel: https://www.youtube.com/c/whatatimetobealive Get one of our t-shirts, or other merch, using this link! https://whatatimepod.bigcartel.com/ whatatimepod.com Join our Discord chat here: discord.gg/jx7rB7J @pattymo // @kathbarbadoro // @eliyudin // @whatatimepod © 2023 What A Time LLC

Join Laura and Jaci Stephans as we go over and discuss the Carnivore Diet.Research:Carnivore Code Book Other ResearchWhat is Phytase - https://www.webmd.com/vitamins/ai/ingredientmono-1619/phytasePhytase and Human Nutrition - https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3434231#:~:text=Phytases%20have%20been%20identified%20in,konietzny%20and%20greiner%2C%202002).Phytic Acid and DNA Damage - https://pubmed.ncbi.nlm.nih.gov/11676478/Phytic Acid and Inositol for Improved Insulin Sensitivity - https://www.sciencedirect.com/science/article/abs/pii/S0271531714001225?via%3DihubAre AntiNutritients Harmful - https://www.hsph.harvard.edu/nutritionsource/anti-nutrients/Stone Age Humans and Plant Glucose - https://ec.europa.eu/research-and-innovation/en/horizon-magazine/how-stone-age-humans-unlocked-glucose-plantsThe Paleolithic Diet - https://www.ncbi.nlm.nih.gov/books/NBK482457/#:~:text=Plants%20%2D%20These%20included%20tubers%2C%20seeds,process%20and%20cook%20these%20foods.To learn more visit www.ShiftHealthCoach.comSupport the showSchedule a free 15 session with me or purchase a full session and walk away with an actionable plan. To learn more, visit www.ShiftHealthCoach.comMusic by Alex Grohl and Pixabay click here to listen to learn more

Dr Rob waxes eloquent about some amazing new revelations involving DNA damage repair systems. Researchers recently turned AI onto the human genome, probing the genes and gene systems that are involved in maintaining and repairing DNA. The results shocked everyone. Many more genes that anyone thought are required, and entire new repair systems were discovered. So what came first, DNA or the amazing repair systems required to maintain DNA that are, in turn, coded into DNA? The point is that these systems are absolutely necessary for living things, yet they are also incredibly complicated. They would never be expected to arise without help, but without them the entire DNA system (not just the code, but the DNA itself) could never exist. Evolution, in this case, simply fails to explain much of anything. Links: Kratz et al. 2023. A multi-scale map of protein assemblies in the DNA damage response. Cell Syst 14(6):447-463.e8; https://pubmed.ncbi.nlm.nih.gov/37220749/

Dr Rob waxes eloquent about some amazing new revelations involving DNA damage repair systems. Researchers recently turned AI onto the human genome, probing the genes and gene systems that are involved in maintaining and repairing DNA. The results shocked everyone. Many more genes that anyone thought are required, and entire new repair systems were discovered. So what came first, DNA or the amazing repair systems required to maintain DNA that are, in turn, coded into DNA? The point is that these systems are absolutely necessary for living things, yet they are also incredibly complicated. They would never be expected to arise without help, but without them the entire DNA system (not just the code, but the DNA itself) could never exist. Evolution, in this case, simply fails to explain much of anything. Links: Kratz et al. 2023. A multi-scale map of protein assemblies in the DNA damage response. Cell Syst 14(6):447-463.e8; https://pubmed.ncbi.nlm.nih.gov/37220749/

Are you tired of the same old cancer treatment methods that leave you feeling drained and hopeless? Look no further than the Integrative Cancer Solutions with Dr. Karlfeldt. In our latest episode, we have Dr. Stephen Iacoboni, a medical oncologist with over 40 years of experience, discussing the use of naturopathic remedies alongside chemotherapy to overcome drug resistance. Our goal is to educate and inform our listeners about alternative cancer solutions that have been successful for others. Dr. Iacoboni shares his expertise in integrative oncology and explains why he believes that academic institutions have a primary mission of research, while a doctor in the community has a primary mission of patient care. The conversation also touches on the pros and cons of chemotherapy and the emerging direction of immunotherapy. Join us as we explore the history and progress of cancer treatment, breakthroughs in oncology, and alternative tools and treatments. Don't miss out on this informative and eye-opening episode. Tune in to Integrative Cancer Solutions with Dr. Karlfeldt today.- Alternative cancer treatments- Naturopathic remedies- Integrative oncology- Evolution of medical oncology- Pros and cons of chemotherapy- Immunotherapy limitations- Insulin Potentiated Therapy- Hyperoxidative therapy- Exploiting cancer cell vulnerabilities- Antioxidants and cancer- Nutraceuticals in cancer treatment- Revolution in oncology- Telos book and purpose in life- Scientific atheism and faith- Patient-centered care- Educational purposes only- Karlfeldt Center promotionKEY POINTS[0:0:32] With integrative and holistic methods, it's possible to WIN the fight against cancer.[0:5:16] Academic institutions are dedicated to pushing the boundaries of knowledge, while doctors are devoted to providing life-saving care to their patients.[0:8:53] In the last four decades, medical oncology has seen a remarkable transformation, from primitive radiation and surgical treatments to the development of revolutionary chemotherapy and immunotherapy treatments.[0:14:22] Shockingly, traditional cancer therapies often come with debilitating side effects - but luckily, there are now alternative solutions available![0:16:44] Miraculously, over 90% of early stage cancer cases can be successfully cured – giving hope to those facing the devastating diagnosis of stage four cancer.[0:21:39] By strategically targeting the oxidative state of cancer cells with Vitamin C and K3 at a specific ratio, researchers have uncovered an incredibly empowering and overlooked vulnerability in the fight against cancer.[0:22:10] Chemotherapy is a much less lethal and more effective alternative to Cyanide for treating cancer, with the power to eradicate cancerous cells on a much larger scale.[0:26:25] Cancer cells exhibit an alarming, frenetic energy level, devouring vast amounts of energy to fuel their rapid growth.[0:27:42] By leveraging the power of Prooxidants, cancer cells can be efficiently destroyed with reduced chemo doses, effectively cutting off their crucial supply of antioxidants![0:30:20] Despite the exorbitant price of cancer medications, some physicians prioritize patient health above profit, delivering effective and accessible treatments to improve the lives of those affected.[0:36:22] By revolutionizing oncology, we could dramatically reduce Medicare costs, saving billions of dollars and dramatically improving the lives of countless patients.[0:46:24] Incredibly, nutraceuticals with hyperoxidation properties have the potential to halt the progression of pre-cancerous cells, offering a cost-effective alternative to traditional cancer prevention methods. Connect with Stephen at https://stepheniacoboni.com/ Integrative Cancer Solutions was created to instill hope and empowerment. Other people have been where you are right now and have already done the research for you. Listen to their stories and journeys and apply what they learned to achieve similar outcomes as they have, cancer remission and an even more fullness of life than before the diagnosis. Guests will discuss what therapies, supplements, and practitioners they relied on to beat cancer. Once diagnosed, time is of the essence. This podcast will dramatically reduce your learning curve as you search for your own solution to cancer. For more information about products and services discussed in this podcast, please visit www.integrativecancersolutions.com. To learn more about the cutting-edge integrative cancer therapies Dr. Karlfeldt offer at his center, please visit www.TheKarlfeldtCenter.com.

Today you'll learn about new treatments the wealthy are using to try and stay young forever, the cultural and social evolution of the word please, and how the snap fit mechanism used in things like lego bricks is being updated for even bigger projects. Find episode transcripts here: https://curiosity-daily-4e53644e.simplecast.com/episodes/immortality-tech-please-is-not-polite-snap-fit-physicsImmortality Tech “People are desperately trying to live forever. Here are the biggest anti-aging trends sweeping the nation.” by Lakshmi Varanasihttps://finance.yahoo.com/news/people-desperately-trying-live-forever-090000189.html“Taking the Plunge: Is Cold Exposure Worthwhile?” by Lisa Fieldshttps://www.cedars-sinai.org/blog/cold-exposure-therapy.html“How can fasting help fight aging?” by Linnea Zielinskihttps://ro.co/health-guide/fasting-and-aging/?irclickid=SG20AsU8gxyNTy0TnAXIvwzyUkAW13QJMWdhz80&irgwc=1&utm_source=impact&utm_medium=affiliate&utm_campaign=10078&utm_content=1262348&utm_term=businessinsider.com&ro_con=1&ro_ch=pubs&ro_p=impact&ro_n=Skimbit%20Ltd.&ro_c=10078&ro_g=Online%20Tracking%20Link&ro_t=1262348&survey_code=Skimbit%20Ltd.“Telomeres, DNA Damage and Ageing: Potential Leads from Ayurvedic Rasayana (Anti-Ageing) Drugs” by Rohit Sharma and Natália Martinshttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465058/“Red Light Therapy” by Cleveland Clinichttps://my.clevelandclinic.org/health/articles/22114-red-light-therapyPlease Is Not Polite “How Please Stopped Being Polite” By Walker Mimmshttps://www.theatlantic.com/family/archive/2023/03/polite-words-is-please-rude/673397/“Oh Please Stop Saying Please” by Choire Sichahttps://www.nytimes.com/2018/12/20/business/ghosting-your-job.html“7 words you probably didn't know were acronyms” by BBChttps://www.bbc.co.uk/programmes/articles/2grMKJ29Ghlw36WXCHGJvKk/7-words-you-probably-didnt-know-were-acronymsSnap Fit Physics  “From LEGOs to Ziploc: The Science of the Snap Fit” by Katharine Gammonhttps://www.insidescience.org/news/legos-ziploc-science-snap-fit“Mechanics of a Snap Fit” by Keisuke Yoshida and Hirofumi Wadahttps://journals.aps.org/prl/abstract/10.1103/PhysRevLett.125.194301“LEGO ‘snap-fit' inspires scientific study” by Adam Baschhttps://www.brickfanatics.com/lego-snap-fit-inspires-scientific-studyFollow Curiosity Daily on your favorite podcast app to get smarter with Calli and Nate — for free! Still curious? Get exclusive science shows, nature documentaries, and more real-life entertainment on discovery+! Go to https://discoveryplus.com/curiosity to start your 7-day free trial. discovery+ is currently only available for US subscribers.