Podcasts about Bruin

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https://www.theguardian.com/us-news/2026/jan/21/ice-arrests-five-year-old-boy-minnesotaUS Immigration and Customs Enforcement (ICE) detained a five-year-old Minnesota boy on Tuesday as he returned home from school and transported him and his father to a Texas detention center, according to school officials.Liam Ramos, a preschooler, and his father were taken into custody while in their driveway, the superintendent of the school district in Columbia Heights, a Minneapolis suburb, said at a press conference on Wednesday. Liam, who had recently turned five, is one of four children in the school district who have been detained by federal immigration agents during the Trump administration's enforcement surge in the region over the last two weeks, the district said. portrait of child wearing black poloLiam Ramos. Photograph: Courtesy of Columbia Heights Public SchoolsLiam and his father had just arrived home when they were detained, according to Zena Stenvik, the superintendent, who said she drove to the home when she learned of the detentions.When she arrived, Stenvik said the father's car was still running and the father and son had already been apprehended. An agent had taken Liam out of the car, led the boy to his front door and directed him to knock on the door asking to be let in, “in order to see if anyone else was home – essentially using a five-year-old as bait”, the superintendent said in a statement. Danielle (00:02):Well, Hey, Jenny, how you doing? I'm hanging in there. How you doing? Same hanging in there a part. I think of it as trying to get in or out of a space and hanging by my fingernails on an edge. That's how I think of it sometimes.(00:27):One time I told a friend, Hey man, I can do a pull up off a door jam. And they were like, really? And I was just like, yeah. And then they tried to do it repeatedly. Their hands were so sore. I was like, I didn't really mean it. I was just joking, but maybe it's like that doing a pull up off a door jam or something. Yeah,Jenny (00:46):I can't even do a normal pull up. I'm working on it. I'm working on my strength.Yeah. I'm trying.Danielle (00:53):Good for you. That's our power.Jenny (00:55):That's right.I am currently in Florida, and so I'm a little worried about this ice storm that's coming through. I think I'm a little bit south of it, so we should hopefully be in the clear, but it's still, you can feel Winter's, the Bruin here.I know. It's a little scary. We're going to just thankfully be parked somewhere where we don't have to drive for at least a few days just in case.Danielle (01:33):Okay, cool. Cool. Will you stay in Florida or what's your trajectory right now?Jenny (01:38):Yeah, we're going to be here probably a couple months, and then we'll probably head over to New Orleans. There's a New Orleans book festival. It's a giant book event, so we're excited for that. And then we'll start probably heading back up to the northeast when it starts to warm up again in late spring, early summer.Yeah. Yeah. So my manuscript is complete and I have sent it to my ideal publisher and they like it and they're going to pitch it by the end of February. So I'm just crossing all my fingers and toes that they all feel like it's a really good fit, and hopefully in about a month from now I'll have a definitive answer, but I have a really good feeling about it. I really value this publisher and yeah, it feels really in alignment with what I'm trying to do with my book.I am trying to help folks understand that their individual body, specifically white cis women in the United States that has been positioned and conditioned within Christian nationalism is just that it is conditioned and positioned by Christian nationalism. And the more that we become aware of that and conscious of that, the more mobility and freedom we can find in our bodies and hopefully in our country and in our world, so that we can move and breathe and have our being in more free sovereign ways.Danielle (03:26):That feels like a little bit of a dream right now, but hey, I'm a dreamer. I'm all over it. Yeah, I'm all over it. I'm all over it. Well, every time we hop on here, I'm always like, oh, what should we talk about? And there's always something really fucked up in the world to dive into, right? Yes.Jenny (03:44):Yeah. Yeah. I think what feels so loud is just in the last 24, 48 hours, I don't know exactly the date five-year-old boy was taken with his dad from Minnesota just immediately basically swept away to another state, and so the family and their lawyer, or even just trying to track down where they are, and I am thinking of four and five-year-olds I know in my life and just how young and how tender and how dependent a child is at that age, and I find myself feeling a lot of rage and a lot of grief and a lot of helplessness, a sense of I want to do something and how do we do something? How about,Danielle (04:40):Let me just read this to us or to us, US Immigration and Customs Enforcement. Ice detained a five-year-old Minnesota boy. On Tuesdays, he returned home from school and transported him and later his father to a Texas detention center. According to school officials, Liam Ramos, a preschooler and his father were taken into custody while in their driveway, the superintendent of the school district in Columbia Heights, a Minneapolis suburb, said at a press conference on Wednesday, Liam who had recently turned five is one of four children in the school district who have been detained by federal immigration agents during the Trump administration's enforcement surge in the region over the last two weeks. The district said Liam and his father had just arrived home when they were detained. According to Zena Sten, the superintendent who said she drove to the home when she learned of the detentions. Wow.(05:31):When she arrived, SVI said the father's car was still running and the father and son had already been apprehended. An agent had taken Liam out of the car, led the boy to his front door and directed him to knock on the door, asking to be let in order to see if anyone else was home, essentially using a five-year-old as bait. The superintendent said in a statement, Stenbeck said Another adult living in the home was outside during the encounter and had pleaded to take care of Liam so the boy could avoid detention but was denied. Liam's older brother, a middle schooler came home 20 minutes later to find his father and brother missing. Stenbeck said two school principals from the district also arrived at the home to offer support. Mark Osh, an attorney representing the family, said the family had an active asylum case and shared paperwork showing the father and son had arrived at the US at a port of entry, meaning an official crossing point.(06:22):The family did everything they were supposed to in accordance with how the rules have been set out. He said they did not come here illegally. They're not criminals. He said there was no order of deportation against them, and he believes the father and son have remained together. In detention, school officials released two photos of the encounter, one showing Liam in a blue knit hat outside his front door with a masked agent at his side and another showing Liam standing by a car with a man holding onto his backpack. Why did tain a five-year-old, you could not tell me this child is going to be classified as violent criminal. Stevi said. Tricia McLaughlin, director Department of Homeland Security Assistant Secretary, said in a statement on Wednesday night that ICE was conducting a targeted operation to arrest Liam's father, who she called an illegal alien. Ice did not target a child, she said McLaughlin also alleged the father fled on foot, abandoning his child, saying, for the child's safety, one of our ice officers remained with the child while the other officers apprehended.(07:21):His father. Parents are asked if they want to be removed with their children or ICE will place the children with a safe person. The parent designates. She added the school district provided a statement from Liam's teacher who expressed shock over the boy's attention. Liam is a bright young student. He's so kind and loving, and his classmates miss him. He comes into class every day and just brightens the room. All I want for him is to be back here and safe. The detention of a young child will have ripple effects at Prakash. Once his classmates learned, the government took him away. I'm not qualified to talk about how much damage that is going to cause. It's not just the family. It's the entire community and all those kids who are now going to be facing secondary trauma. Also, on Tuesday, a 17-year-old Columbia Heights student was taken armed by armed and masked agents without parents present.(08:12):Stevi said that student was removed from their car. She said in another case, on the 14th of January, ICE agents pushed their way into an apartment and detained a 17-year-old high school girl. And her mother, Stevi said in a fourth case on January 6th, a 10-year-old fourth grade student was allegedly taken by ice on her way to elementary school with her mother. The superintendent said the 10-year-old called her father during the arrest and said the ICE agents would bring her to school. But when the father arrived at the school, he discovered his daughter and wife had been taken. By the end of that school day, the mother and daughter were in detention center in Texas.(08:48):Vic reported that as school officials are preparing for a press conference on Wednesday afternoon, an ice vehicle drove to the property of the district's school and we're told by administrators to leave ice agents have been roaming our neighborhoods, circling our schools, following our buses, coming onto our parking lots and taking our kids stem said the DHS did not respond to inquiries about other arrests and the Port of ICE's arrival on campus. In an interview after the press conference, the superintendent said The arrests and looming presence of vice had taken an enormous toll on students, parents, and school staff. Our children are traumatized. The sense of safety in our community and around our schools is shaken. Stenbeck said, I can speak on behalf of all school staff when I say our hearts are shattered, and our fourth student was taken yesterday. I just thought someone has to hear the story they're taking children. School officials said, some families are choosing to stay home out of fear of ice. Stevi said, school leaders we're working to aid families affected by ice. Our role is to educate children during the school day, but now we're trying to help people navigate this legal system. She added our main priority is to keep children safe. They're children. They're not violent criminals. They're little kids.(10:01):Hey, Rebecca. I was just reading the story of little Liam who was used as bait to get his father and other family members arrested, and I hadn't read the story before, but he had apparently they walked this boy up to the door and asked him to knock on the door so they could see if anybody else was home. So yeah, thoughts Jenny, Rebecca,I think the word ringing in my head is asylum and that this young boy and his family, so many others have already tried to seek out a safer place only to be met with such violence and harmI think I feel this kind of disbelief that we live in a country where this is what happens in broad daylight and that the conversation we're having as a country is all these ways to justify that any of this is legitimate or humane. And then I feel like I shouldn't be surprised, and I wonder if this is what my ancestors felt like in the 1950s or the 1920s or the 1860s. This kind of way that this is woven into the fabric of American life in a way that it never actually disappears. It just keeps reinventing it and reimagining itself and that every generation falls for that every time. And I don't know how to metabolize that. I can access it academically. I know enough history to know that. And if I try to think about what that felt like and why are we here again, why are we repeating this again? Why are we still doing this?Danielle (14:04):Yeah, I guess I used to think, and I think I've said this many times, I just keep repeating it, that some of this would disrupt the MAGA base. And we've even talked a bit together about Marjorie Taylor Green, but I saw a piece on the Atlantic, let me see if I can find the guy's name done by Yer Rosenberg, and it said, the biggest myth about Trump's base and why many believe it, the magma faithful, the MAGA faithful aren't deserting their leader. And it said in fact that it's like over 80% of the same Republican does support this immigration enforcement. They support what the action that happened in Venezuela, they support the hostile takeover, potential hostile takeover of Greenland.(15:07):And that some of the pushback we're hearing, but maybe you've heard it by Tucker Carlson or Marjorie Taylor Green is really politically motivated. So these folks can position themselves as successors to Trump because Trump has such a, they're saying Trump has a firm grip on the Republican party. And I think I want to push back and be like, well, we're all individuals making choices at the same time. And if you have 85% of an entire voting block saying, I'm okay with this, then why would it stop? Like you said, Rebecca, there's no reason this is going to stop. We can't wait. These people are not changing their minds now. They can see the violence. If you grew up in California and someone was in Alabama and there was a lynching in Alabama or vice versa, or the Chinese were attacked in California, et cetera, you might not know about it. That's not what's happening right now. There's freedom of information. There's social media. We can see the images and with the images, people are still saying, yeah, I'm okay with that. I think that's what strikes me.Rebecca (16:27):And again, I think if you look back historically, it's like we've been okay with this as a country for a very long time, since at the inception of the country, there is a category of people that are three fifths a human, and therefore not entitled to the rights listed under the constitution. We've been okay with this since there was such a thing as the United States of America. And that means that Donald Trump is not the problem. He is the symptom of a problem. He's the current forward face of a problem that has been with us since the very beginning, and that the church in America has sanctioned as biblically acceptable from the very beginning.Which is crazy, right? But the notion that somehow God or any version of him, it is on the side of this, it is absurd. It just is. Yeah. But again, that's the argument the church has put forth the inception since the colonies, since before there was a United States. The church has put forward the notion that God is on the side of this. And it was a lie then and it is a lie now, but it's one that this country is used to swallowing.Jenny (19:36):I am thinking about how almost a year ago now, Sean and I were doing sort of a civil rights circuit. We did Memphis and Birmingham and Montgomery and I, Selma, and then we just so happened as we kind of went through that circuit, we just so happened to be in the major cities that ice rates were happening in Nashville, in Houston, in San Antonio, and we were on the same street the day that children were being ziptied and taken from their court hearings in San Antonio. And we went from there to go visit family who grew me up in a Christian tradition to follow a man who proclaimed good news for the immigrant and for the poor. And I was crying talking about what we had witnessed, what we had physically experienced, not what we had just seen on social media, on news, what we had tangibly seen, the people we talked to and one of these family members.(21:07):The next thing they said was, I think I just saw a raindrop and they were so dissociated and disconnected from themselves, from me, from our relational field, from what was going on that I was just like, if we cannot have this conversation, what hope is there? Where do we put our hope in? How, again, I think a big part of why I am so passionate about this is because of the person that I grew up learning Jesus was and trying to emulate that. And then to see this fracture in those that call themselves Christians and Jesus followers unwilling to even engage what's going on right now. It is so distressing. And I honestly, yeah, like you're saying, I don't think it's new though. I think that somehow this marriage of Christianity and militarization and conquest has been a powerful force, I think really since Constantine and there's, I dunno what it will take to reckon with that.Danielle (22:37):I mean, clearly I think Jenny, you point, information is not enough for people to change even what we could call facts. We can't agree on those facts. So if you take the church scene, I watched it. I actually watched it live last weekend. I was interested in it and I saw him say, we don't know where we're going. His car, his jeep actually got caught in a lot of snow and they were pushing it out. They got in, they were very clear like, Hey, we're just here observing this protest. We're here watching. And they watched and they went, and he has it on Instagram and TikTok, I think Don goes up to the pastor that's there, not the pastor that's associated with ice. And the pastor puts his hand on Don and starts to push him and Don says, do not touch me. Don't touch me.(23:34):Don't push me. I'm not invading your space. But I think that's the visceral response. It's like, let me push away this reality. In my mind, that's the actual thing happening. It is not that Don is seen as a person in that moment. I don't believe that. I don't believe he saw him as a person. I think it was more as I thought about it and I got the chills thinking about it. It's like, let me just push away whatever reality you're walking in with, I want nothing to do with it. And I mean, what really struck me about that too was it was black clergymen in there protesting for Renee. Good. I'm like, oh, this is what it is. It's black independent media showing up and doing this reporting. Yeah, it was very interesting. Rebecca, did you watch any of that?Rebecca 24:34):I did. And I saw a clip of a prisoner walking out of the building saying, I just came here to worship God, and that got disrupted and I'm upset about It was the gist. I mean, that's my paraphrase. But again, I don't know what has to happen to a person, to a people theologically, psychologically, emotionally, physiologically for you to not see, not believe, not metabolize, not feel what you're actually witnessing. And the answer to that is rather scary to me. What you have to believe is true about the God that you claim to serve what you have to believe is true about the people that he created in order to turn a blind eye to what you're not only witnessing but actually participating in to the extent that omission or silence or inaction is actually participation. It is a little scary to me what that means about the American church in this moment. I don't know what to say about that.Jenny (27:52):I was going to say last Sunday we had the opportunity to go to Ebenezer Baptist, which was the church that MLK was a pastor of. Did we talk about that on here? Not really,(28:07):Yeah. And Warnock gave the sermon for the day and it ended with Renee good's face up on the screen where the worship music usually shows and him talking about what it means to account the cost in this moment and to stay the course in this battle that we're in. That's very real and very serious. And to be in that place in MLK's old church on the week that Renee Goode was murdered, it just was both kind of just a reality check, but also encouraging to just be as scary and loud and big and gaslighting as all of this is. We've been to 44 states in the last two years, and there are amazing people in every single one of them doing incredible things and looking at the community in Minneapolis with their whistles, with their defiance, with their sledding competitions, just to see the various ways in which defiance and resistance is taking place. I feel like that has been something that has been giving me a thread of hope in the midst of everything.Danielle (29:51):Yeah, I think I was thinking that yesterday. There's so much piled up trauma and so many people that are disrupted by it, as they should be, and so much, I was talking to someone the other day and they're like, I'm anxious. I'm like, I'm anxious too. How could you not be anxious even if you're kind of oblivious? I feel like the waves just travel. But I mean, not to be trite, but I think I listen to Jamar Tse a lot and he was talking about one way to combat despair is building your community has to hold hope. You can't do it by yourself. So taking action or reflection or being with other people or talking it out or showing emotion. I think those are real things. And I dunno, I guess coming back to therapy, just kind of that ingrained sense of you can't take an action to get out of your situation or change things, but I don't know where I learned that or picked that up, but I think that taking an action when you feel like shit actually does help. It's going on a walk or going for a run, and I don't know the chemistry to this, maybe you know it more than me, but something starts busting loose in the chemistry, and even if it doesn't last forever, it changes for a minute.Don't know. Do you know what changes or what the chemistry is for that?Jenny (31:30):Yeah. Well, I think that there are few things more distressing for our nervous system than immobility. So at least when we are protesting or we're running or we're lifting weights or we're doing something, it's letting our body feel that sympathetic fight flight energy that's like, well, at least I can do something and I might not be able to escape this situation. I might not be able to change it, but I can feel a little bit more movement in my own body to figure out how I can maneuver in and through it.(32:14):And so even that, as we do that, when we do move or exercise, we're releasing a lot of adrenaline and cortisol. We're working that through our system, and we're also producing a lot of natural opiates and feel good chemicals. So there is something very real and physiological to lately I've been just needing to go do the stairs machine at the gym, and I've just been like, I need to walk up a mountain and feel my body be able to do that. And yeah, it doesn't last forever, but maybe for a couple hours afterwards I'm like, okay, I feel good enough to stay in this and not check out. And I had a friend send me something today that was talking about how a lot of people think they're overwhelmed and we are going through something that's overwhelming. And a lot of that overwhelm is actually that we're taking in so much and we're not doing anything with it.(33:21):And so whether or not what you do changes or fixes it, you actually need some way to let your body process the adrenaline, the stress, the cortisol, and all of those things. And that, I think helps our body. If we look at cultures across the globe when they've been preparing for war, look at the haka and these dances that are like, they're not in it. They're not fighting the war, but they're doing something to let their bodies feel in connection with other bodies to feel their strength and to get prepared for whatever they need to be prepared for.Danielle (33:59):Right. Yeah. That's so cool. Every time I watch that dance, I'm like, oh, I wish I had that. But I feel like the Seahawks kind of provide that, just that yelling or screaming or whatever.Jenny (34:18):Totally. Or going on a roller coaster. There's not a lot of places we have permission to just scream. I do in the car a lot while I'm driving. I'll just be like, and it really helped a lot.Danielle (34:34):It's so interesting how we can go from that intense story though, hit the church stuff and then the conversation can come back to here. But I do think that's a reflection of how we kind of have to approach the moment too. There's no way to metabolize all the stuff in the article. It's deeply overwhelming. One aspect probably couldn't be metabolized in a day. I dunno. Does that make sense?Yeah. How are you looking at the next week then, Jenny, as you think of that, even that kind of structure we went through, how do you imagine even the next week? It's hard to imagine the next week. I feel like we never know what's going to happen.Jenny (35:15):I know I feel very grateful that we're in a place where we have really good friends and community and support. So this week looks like dinners with our friends, engaging what's going on. We're very close to this really local bookstore that gets letters from folks in prison about what kind of book they want. And then you go find the book and you pack it and you mail it to them. What(35:52):So we're going to volunteer in there and send some books to folks in prison and just do things. And it's not changing everything, but I believe that if everybody focused on doing the right thing that was right in front of them, we would have a much different world and a less associated apathetic world. I plan on going to the gym a lot and working out, getting buff, working out my running may or may not be disrupting some more standup open mic comedy nights. We'll see. PostSpeaker 1 (36:31):What about you? What's your week look like?Danielle (36:39):I tend to set, I tell myself I love the weekends because Saturdays and Sundays are my days full days off. So I tend to tell myself, oh, I can't wait for that. But then in the week I tell myself, these might seem silly, but I say, oh man, there's so much hard stuff. But then I tell myself, I don't want to rush a day because I really like to see my kids. So then each day I think, well, I have work that's cool. I have these other tasks. And then when I get outside of work, I look forward, I try to tell myself, oh, I'm going to eat something I really like. I'm going to give my kid a hug. I'm going to hear about their day.(37:16):I like to lay flat on my back after work, even before I eat, just to kind of reset. I look forward to that moment. Seems silly. I like that at noon every day. Usually reserve my time to work out. And even if I don't push myself hard, I go just to hug the people. And sometimes I get there early and I sit in a corner and they're like, what are you doing? I'm like, I'm mentally warming up. So those are the kind of things, it sounds mundane, but I need really basic, dependable rhythms. I know I can execute.Yeah, yeah, yeah. Guess what? I really have to go to the bathroom.   Well, first I guess I would have to believe that there was or is an actual political dialogue taking place that I could potentially be a part of. And honestly, I'm not sure that I believe that.

Enjoy the What's Bruin Show Network!Multiple shows to entertain you on one feed:Support WBS at Patreon.com/WhatsBruinShow for just $2/month and get exclusive content and access to our SLACK channel.Twitter/X: @whatsbruinshow        Instagram: @whatsbruinshowCall the What's Bruin Network Hotline at 805-399-4WBS (Suck it Reign of Troy)We are also on YouTube HEREGet Your WBSN MERCH - Go to our MyLocker Site by Clicking HEREWhat's Bruin Show- A conversation about all things Bruin over drinks with Bruin Report Online's @mikeregaladoLA, @wbjake68 and friends!Subscribe to the What's Bruin Show at whatsbruin.substack.comEmail us at: whatsbruinshow@gmail.comTweet us at: @whatsbruinshowWest Coast Bias - LA Sports (mostly Lakers, Dodgers and NFL) with Jamaal and JakeSubscribe to West Coast Bias at wbwestcoastbias.substack.comEmail us at: WB.westcoastbias@gmail.comTweet us at: @WBwestcoastbiasThe BEAR Minimum - Jake and his Daughter Megan talk about student life and Cal Sports during her first year attending UC Berkeley.Subscribe to The BEAR Minimum at thebearminimum.substack.comEmail us at: wb.bearminimum@gmail.comTweet us at: @WB_BearMinimumPlease rate and review us on whatever platform you listen on.

Success in real estate isn't built on shortcuts or trends. It's built on clear principles and intentional action over time. In this episode, Dylan de Bruin shares 26 guiding principles that have shaped his leadership, his team, and his career over the past 20 years. The conversation centers on putting people before transactions, creating real value, consulting instead of selling, and building the habits and mindset required for long-term success.   00:00 Introduction to the More Than More Podcast 00:24 Reflecting on Strategic Planning and Success 01:15 Principles for Success in 2026 01:22 Putting People Before Transactions 01:59 Creating Value Before Expecting Returns 02:47 Focusing on Positivity and Control 06:46 Defining Success and Prioritizing 07:56 Winning the Day and Long-Term Thinking 11:19 Gratitude and Positive Surroundings 14:36 Essentialism and Business Pathways 16:09 Delivering Leadership, Relationship, and Creativity 16:42 Final Thoughts and Encouragement   Subscribe to the More Than More Podcast for new weekly episodes as we discuss building meaningful and impactful businesses, careers, and lives through real estate. Apple Podcasts Spotify YouTube 

Enjoy the What's Bruin Show Network!Multiple shows to entertain you on one feed:Support WBS at Patreon.com/WhatsBruinShow for just $2/month and get exclusive content and access to our SLACK channel.Twitter/X: @whatsbruinshow        Instagram: @whatsbruinshowCall the What's Bruin Network Hotline at 805-399-4WBS (Suck it Reign of Troy)We are also on YouTube HEREGet Your WBSN MERCH - Go to our MyLocker Site by Clicking HEREWhat's Bruin Show- A conversation about all things Bruin over drinks with Bruin Report Online's @mikeregaladoLA, @wbjake68 and friends!Subscribe to the What's Bruin Show at whatsbruin.substack.comEmail us at: whatsbruinshow@gmail.comTweet us at: @whatsbruinshowWest Coast Bias - LA Sports (mostly Lakers, Dodgers and NFL) with Jamaal and JakeSubscribe to West Coast Bias at wbwestcoastbias.substack.comEmail us at: WB.westcoastbias@gmail.comTweet us at: @WBwestcoastbiasThe BEAR Minimum - Jake and his Daughter Megan talk about student life and Cal Sports during her first year attending UC Berkeley.Subscribe to The BEAR Minimum at thebearminimum.substack.comEmail us at: wb.bearminimum@gmail.comTweet us at: @WB_BearMinimumPlease rate and review us on whatever platform you listen on.

Enjoy the What's Bruin Show Network!Multiple shows to entertain you on one feed:Support WBS at Patreon.com/WhatsBruinShow for just $2/month and get exclusive content and access to our SLACK channel.Twitter/X: @whatsbruinshow        Instagram: @whatsbruinshowCall the What's Bruin Network Hotline at 805-399-4WBS (Suck it Reign of Troy)We are also on YouTube HEREGet Your WBSN MERCH - Go to our MyLocker Site by Clicking HEREWhat's Bruin Show- A conversation about all things Bruin over drinks with Bruin Report Online's @mikeregaladoLA, @wbjake68 and friends!Subscribe to the What's Bruin Show at whatsbruin.substack.comEmail us at: whatsbruinshow@gmail.comTweet us at: @whatsbruinshowWest Coast Bias - LA Sports (mostly Lakers, Dodgers and NFL) with Jamaal and JakeSubscribe to West Coast Bias at wbwestcoastbias.substack.comEmail us at: WB.westcoastbias@gmail.comTweet us at: @WBwestcoastbiasThe BEAR Minimum - Jake and his Daughter Megan talk about student life and Cal Sports during her first year attending UC Berkeley.Subscribe to The BEAR Minimum at thebearminimum.substack.comEmail us at: wb.bearminimum@gmail.comTweet us at: @WB_BearMinimumPlease rate and review us on whatever platform you listen on.

Listen to UCLA Professor Michael Tsiang describe his education and career path from studying mathematics at UCSC to being accidentally admitted to a PhD program at UBC, to working at Target, to his eventual career as a Statistics Professor here at UCLA!

Enjoy the What's Bruin Show Network!Multiple shows to entertain you on one feed:Support WBS at Patreon.com/WhatsBruinShow for just $2/month and get exclusive content and access to our SLACK channel.Twitter/X: @whatsbruinshow        Instagram: @whatsbruinshowCall the What's Bruin Network Hotline at 805-399-4WBS (Suck it Reign of Troy)We are also on YouTube HEREGet Your WBSN MERCH - Go to our MyLocker Site by Clicking HEREWhat's Bruin Show- A conversation about all things Bruin over drinks with Bruin Report Online's @mikeregaladoLA, @wbjake68 and friends!Subscribe to the What's Bruin Show at whatsbruin.substack.comEmail us at: whatsbruinshow@gmail.comTweet us at: @whatsbruinshowWest Coast Bias - LA Sports (mostly Lakers, Dodgers and NFL) with Jamaal and JakeSubscribe to West Coast Bias at wbwestcoastbias.substack.comEmail us at: WB.westcoastbias@gmail.comTweet us at: @WBwestcoastbiasThe BEAR Minimum - Jake and his Daughter Megan talk about student life and Cal Sports during her first year attending UC Berkeley.Subscribe to The BEAR Minimum at thebearminimum.substack.comEmail us at: wb.bearminimum@gmail.comTweet us at: @WB_BearMinimumPlease rate and review us on whatever platform you listen on.

Enjoy the What's Bruin Show Network!Multiple shows to entertain you on one feed:Support WBS at Patreon.com/WhatsBruinShow for just $2/month and get exclusive content and access to our SLACK channel.Twitter/X: @whatsbruinshow        Instagram: @whatsbruinshowCall the What's Bruin Network Hotline at 805-399-4WBS (Suck it Reign of Troy)We are also on YouTube HEREGet Your WBSN MERCH - Go to our MyLocker Site by Clicking HEREWhat's Bruin Show- A conversation about all things Bruin over drinks with Bruin Report Online's @mikeregaladoLA, @wbjake68 and friends!Subscribe to the What's Bruin Show at whatsbruin.substack.comEmail us at: whatsbruinshow@gmail.comTweet us at: @whatsbruinshowWest Coast Bias - LA Sports (mostly Lakers, Dodgers and NFL) with Jamaal and JakeSubscribe to West Coast Bias at wbwestcoastbias.substack.comEmail us at: WB.westcoastbias@gmail.comTweet us at: @WBwestcoastbiasThe BEAR Minimum - Jake and his Daughter Megan talk about student life and Cal Sports during her first year attending UC Berkeley.Subscribe to The BEAR Minimum at thebearminimum.substack.comEmail us at: wb.bearminimum@gmail.comTweet us at: @WB_BearMinimumPlease rate and review us on whatever platform you listen on.

The 1976 Rose Bowl wasn't necessarily a game for Ohio State to win, but rather a coronation for their National Championship. They were facing Dick Vermeil's Bruins in Pasadena, having already battered UCLA in the regular season, 41-20 at the L.A. Coliseum. The Buckeyes were favored by 15/5 points to do it again and end their season unbeaten, untied and unblemished.  However, with an opportunity to play the top ranked Buckeyes a 2nd time, Vermeil practiced hard instituting double days on his Bruins team as if it was the beginning of the season all over again. And in front of a national audience and 105,464 fans at the Rose Bowl, Ohio State went into halftime of the rematch with just a 3-0 lead. That's when Vermeil called an audible. His vaunted option offense which had scored 20 points off OSU in the first matchup, the most Ohio State had given up all season, hadn't done a thing in the first 30 minutes of the New Year's Day game. So he told his quarterback John Sciarra that in the 3rd quarter they were scrapping the gameplan… they were going to open things up and start passing. And it worked. Sciarra connected with Wally Henry for two scores the 2nd one covering 67 yards and UCLA had a shocking 16-3 lead over the heavily favored Buckeyes. A 54-yard TD run in the 4th quarter by Wendell Tyler made it 23-10 Bruins and that is how it would finish. The last Rose Bowl Woody Hayes would ever coach ended in a dramatic loss to Vermeil and his Bruins led by Rose Bowl Game MVP John Sciarra who finished the game completing 13 of his 19 passes for 212 yards and 2 touchdowns. 50 years later, Sciarra recalls how he could have been the Heisman Trophy winner had the Bruins won the first meeting instead of the second one with Ohio State and how he would never trade the Heisman for that Rose Bowl win he guided his team to. He remembers how he led the team into a meeting to complain to their coach about the two-a-day practices leading up to the Rose Bowl… and tells us Vermeil's shocking answer to them that paved the way for their win. He also recollects how at the half his coach told him they were going to make adjustments and to be ready to let ‘er rip in the 2nd half. And he tells a great story about how his best buddy and fellow former UCLA QB Mark Harmon cast him in a movie and the role he was born to play! But mostly, he reminisces about the greatest half of football he and his Bruin teammates ever played on New Year's Day, 1976 on the Past Our Prime podcast. Learn more about your ad choices. Visit megaphone.fm/adchoices

We kick off Season 6 of TNQAF by looking at the remaining shorts (and revival) of Chuck Jones' Three Bears Cartoons! We cover their first outing after meeting Bugs Bunny with Papa just trying to sleep through hibernation with 'What's Brewin, Bruin' Jordan covers Papa and Junior trying to take care of their supply of Honey in 'The Bee-Deviled Bruin' And we jump in time 74 years to covering the Browngardt crew's efforts in 'Life's a Beach' and 'Moody at the Movies'Links:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Support us on Patreon⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Follow us on Twitter⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Follow us on Bluesky⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Follow us on Instagram

In this episode of the Oncology Brothers podcast, we were joined by Dr. Julie Vose, a leading expert in lymphoma from the University of Nebraska Medical Center. Together, we delved into the key abstracts presented at ASH 2025, focusing on significant studies in lymphoma and chronic lymphocytic leukemia (CLL). Episode Highlights: ● EPCORE FL-1: the approval of Epcoritamab in combination with Rituximab and lenalidomide for relapsed refractory follicular lymphoma ● CLL-17: comparison between continuous BTK inhibitors and fixed-duration venetoclax with obinutuzumab ● BRUIN CLL-313: insights into the non-covalent BTK inhibitor, pirtobrutinib, and its effectiveness in the frontline setting compared to traditional treatments ● S1826: a three-year update on the use of Nivolumab-AVD versus BV-AVD in advanced-stage Hodgkin's lymphoma, showcasing improved PFS and better tolerability Join us as we unpack these practice-changing studies and discuss their implications for community oncologists. Follow us on social media: •⁠  ⁠X/Twitter: https://twitter.com/oncbrothers •⁠  ⁠Instagram: https://www.instagram.com/oncbrothers •⁠  Website: https://oncbrothers.com/ Don't forget to subscribe for more insights and highlights from oncology conferences! #ASH25 #Oncology #Hematology #Lymphoma #CLL #CancerResearch

Enjoy the What's Bruin Show Network!Multiple shows to entertain you on one feed:Support WBS at Patreon.com/WhatsBruinShow for just $2/month and get exclusive content and access to our SLACK channel.Twitter/X: @whatsbruinshow        Instagram: @whatsbruinshowCall the What's Bruin Network Hotline at 805-399-4WBS (Suck it Reign of Troy)We are also on YouTube HEREGet Your WBSN MERCH - Go to our MyLocker Site by Clicking HEREWhat's Bruin Show- A conversation about all things Bruin over drinks with Bruin Report Online's @mikeregaladoLA, @wbjake68 and friends!Subscribe to the What's Bruin Show at whatsbruin.substack.comEmail us at: whatsbruinshow@gmail.comTweet us at: @whatsbruinshowWest Coast Bias - LA Sports (mostly Lakers, Dodgers and NFL) with Jamaal and JakeSubscribe to West Coast Bias at wbwestcoastbias.substack.comEmail us at: WB.westcoastbias@gmail.comTweet us at: @WBwestcoastbiasThe BEAR Minimum - Jake and his Daughter Megan talk about student life and Cal Sports during her first year attending UC Berkeley.Subscribe to The BEAR Minimum at thebearminimum.substack.comEmail us at: wb.bearminimum@gmail.comTweet us at: @WB_BearMinimumPlease rate and review us on whatever platform you listen on.

• Support & get perks!• Proudly sponsored by PyMC Labs. Get in touch and tell them you come from LBS!• Intro to Bayes and Advanced Regression courses (first 2 lessons free)Our theme music is « Good Bayesian », by Baba Brinkman (feat MC Lars and Mega Ran). Check out his awesome work !Chapters:13:16 Understanding Adaptive and Platform Trials25:25 Real-World Applications and Innovations in Trials34:11 Challenges in Implementing Bayesian Adaptive Trials42:09 The Birth of a Simulation Tool44:10 The Importance of Simulated Data48:36 Lessons from High-Stakes Trials52:53 Navigating Adaptive Trial Designs56:55 Communicating Complexity to Stakeholders01:02:29 The Future of Clinical Trials01:10:24 Skills for the Next Generation of StatisticiansThank you to my Patrons for making this episode possible!Yusuke Saito, Avi Bryant, Giuliano Cruz, Tradd Salvo, William Benton, James Ahloy, Robin Taylor,, Chad Scherrer, Zwelithini Tunyiswa, Bertrand Wilden, James Thompson, Stephen Oates, Gian Luca Di Tanna, Jack Wells, Matthew Maldonado, Ian Costley, Ally Salim, Larry Gill, Ian Moran, Paul Oreto, Colin Caprani, Colin Carroll, Nathaniel Burbank, Michael Osthege, Rémi Louf, Clive Edelsten, Henri Wallen, Hugo Botha, Vinh Nguyen, Marcin Elantkowski, Adam C. Smith, Will Kurt, Andrew Moskowitz, Hector Munoz, Marco Gorelli, Simon Kessell, Bradley Rode, Patrick Kelley, Rick Anderson, Casper de Bruin, Michael Hankin, Cameron Smith, Tomáš Frýda, Ryan Wesslen, Andreas Netti, Riley King, Yoshiyuki Hamajima, Sven De Maeyer, Michael DeCrescenzo, Fergal M, Mason Yahr, Naoya Kanai, Aubrey Clayton, Omri Har Shemesh, Scott Anthony Robson, Robert Yolken, Or Duek, Pavel Dusek, Paul Cox, Andreas Kröpelin, Raphaël R, Nicolas Rode, Gabriel Stechschulte, Arkady, Kurt TeKolste, Marcus Nölke, Maggi Mackintosh, Grant Pezzolesi, Joshua Meehl, Javier Sabio, Kristian Higgins, Matt Rosinski, Luis Fonseca, Dante Gates, Matt Niccolls, Maksim Kuznecov, Michael Thomas, Luke Gorrie, Cory Kiser, Julio, Edvin Saveljev, Frederick Ayala, Jeffrey Powell, Gal Kampel, Adan Romero, Blake Walters, Jonathan Morgan, Francesco Madrisotti, Ivy Huang, Gary Clarke, Robert Flannery, Rasmus Hindström, Stefan, Corey Abshire, Mike Loncaric, Ronald Legere, Sergio Dolia, Michael Cao, Yiğit Aşık, Suyog Chandramouli, Guillaume Berthon, Avenicio Baca, Spencer Boucher, Krzysztof Lechowski, Danimal, Jácint Juhász, Sander and Philippe.Links from the show:Berry ConsultantsScott's podcastLBS #45 Biostats & Clinical Trial Design, with Frank Harrell

How can we motivate children to do well at school and home?Engendering motivation in children can be divided into two key areas: intrinsic motivators, i.e. the motivation that comes from within a pupil, such as having a sense of success when completing a task, and extrinsic motivation, that which is developed by external factors, like praise and stickers.In this episode, Isabel and David are joined by an old friend, co-founder of the pod, Ross Borthwick, to consider the question of motivation.In this discussion about education and the best way to inspire children, they drift perilously close to discovering the meaning of life! To find out more, you'll have to listen to the episode.We are, as always, an independent and unfunded group of teachers and educators. If you like this episode, please do share it with friends and family, post it on social media and give us a review and a 5* rating. It all helps for a small pod out there in the big world of mega podcasters.If you have an idea for an episode or there's something you'd like to talk to us about, get in touch by email: educationsensepod@gmail.com. You can also find Isabel, David & Ross on LinkedIn (though Ross if more likely to be found roaming the Munros and mountains of the Highlands when he's not teaching).Links & References:Video about empathy-based classrooms - https://bit.ly/496MmUlGreat advice about parents motivating at home - https://bit.ly/4jbGePsInteresting article on parents & praise from The Atlantic - https://bit.ly/48X2F61Harvard research about doing chores as a child being the secret to success - https://bit.ly/3Y3KtCNWorth the Effort: Start and Stick to Desirable Difficulties (2023), de Bruin et al https://bit.ly/3MDfjzTStudent Motivation and Associated Outcomes: A Meta-Analysis From Self-Determination Theory (2021), Howard et al https://bit.ly/3N9qOyXIt's Ok, not everyone can be good at maths (2011), Rattan, Good, Dweck et al https://bit.ly/45jJlPkWho Perseveres in School (2026), Li & King https://bit.ly/4qg02TTA Room with a Viewpoint (2008), Goldstein et al https://bit.ly/3Y3KHK9Switch: How to Change Things When Change is Hard (2012), Heath, C & Heath, D, Random House Business

What's up and welcome back to the Something's Bruin Podcast!!! On today's episode, Mel and Sully discuss their holiday plans, begin scoreboard/standings watching, discuss the Bruins defensive depth, dive into the DMs + much more! Happy Holidays!

Enjoy the What's Bruin Show Network!Multiple shows to entertain you on one feed:Support WBS at Patreon.com/WhatsBruinShow for just $2/month and get exclusive content and access to our SLACK channel.Twitter/X: @whatsbruinshow        Instagram: @whatsbruinshowCall the What's Bruin Network Hotline at 805-399-4WBS (Suck it Reign of Troy)We are also on YouTube HEREGet Your WBSN MERCH - Go to our MyLocker Site by Clicking HEREWhat's Bruin Show- A conversation about all things Bruin over drinks with Bruin Report Online's @mikeregaladoLA, @wbjake68 and friends!Subscribe to the What's Bruin Show at whatsbruin.substack.comEmail us at: whatsbruinshow@gmail.comTweet us at: @whatsbruinshowWest Coast Bias - LA Sports (mostly Lakers, Dodgers and NFL) with Jamaal and JakeSubscribe to West Coast Bias at wbwestcoastbias.substack.comEmail us at: WB.westcoastbias@gmail.comTweet us at: @WBwestcoastbiasThe BEAR Minimum - Jake and his Daughter Megan talk about student life and Cal Sports during her first year attending UC Berkeley.Subscribe to The BEAR Minimum at thebearminimum.substack.comEmail us at: wb.bearminimum@gmail.comTweet us at: @WB_BearMinimumPlease rate and review us on whatever platform you listen on.

Two Onc Docs, hosted by Samantha A. Armstrong, MD, and Karine Tawagi, MD, is a podcast dedicated to providing current and future oncologists and hematologists with the knowledge they need to ace their boards and deliver quality patient care. Dr Armstrong is a hematologist/oncologist and assistant professor of clinical medicine at Indiana University Health in Indianapolis. Dr Tawagi is a hematologist/oncologist and assistant professor of clinical medicine at the University of Illinois in Chicago. In this episode, OncLive On Air® partnered with Two Onc Docs to highlight chronic lymphocytic leukemia (CLL) updates from the 2025 ASH Annual Meeting. Drs Armstrong and Tawagi noted that CLL is typically diagnosed in asymptomatic, elderly individuals presenting with lymphocytosis. A definitive diagnosis is established by confirming the clonality of circulating B lymphocytes via immunoglobulin light chain restriction on flow cytometry, they explained. Treatment initiation is reserved for active disease, which is indicated by B symptoms, progressive cytopenias, threatened organ function, or bulky disease such as splenomegaly, they said. They continued by reporting several prognostic features that denote poor outcomes. Current standard frontline regimens use covalent BTK inhibitors or time-limited targeted regimens that include venetoclax (Venclexta), often combined with an anti-CD20 monoclonal antibody, according to the experts. They added that TKI-based therapy is preferred for patients with high-risk features. The phase 3 BRUIN CLL-313 trial (NCT05023980) investigated pirtobrutinib (Jaypirca), a highly selective noncovalent BTK inhibitor, compared with bendamustine and rituximab (BR) in patients with treatment-naive CLL. The trial showed a significant improvement in progression-free survival with pirtobrutinib vs BR. Pirtobrutinib was also associated with a favorable safety profile, with modest rates of class-associated toxicities, including all-grade bleeding, arthralgia, and atrial fibrillation. Although pirtobrutinib showed superior efficacy in BRUIN CLL-313, the clinical interpretation of these data is complicated because BR is an outdated control arm compared with contemporary frontline standards, Armstrong and Tawagi emphasized. Furthermore, the requirement for indefinite therapy with BTK inhibitors is a sequencing challenge, particularly as pirtobrutinib is currently approved in the post-covalent BTK inhibitor setting, they continued. However, its favorable toxicity profile suggests potential utility in elderly patients with pre-existing cardiovascular comorbidities, they noted. Future studies are focused on comparing pirtobrutinib vs time-limited venetoclax and evaluating various triplet regimens, they concluded.

What's up and welcome back to the Something's Bruin Podcast! On today's episode we briefly discuss our absence, jump into the claim of Vladislav Kolyachonok, Fabian Lysell, Bruins biggest need, dive into Mel's mailbag and break into your twitter replies! Thank you all for listeniong and enjoy the show!

This week's episode will be focusing on an update of a late-breaking abstract presented at ASH 2025 this past week: the Phase 3 BRUIN-CLL 313 trial looking at Pirtobrutinib vs Bendamustine/Rituximab in 1L Chronic Lymphocytic Leukemia (CLL).

Welcome back for the next journey of The Family Express Podcast with Kathryn de Bruin, LMFT and Ronda Evans, LMFT where our destination is resilient and connected families. Our guest today is Riley Fairgrieve, LPC, NCC. Riley speaks about the use of therapeutic tabletop role play gaming in families and peer groups -- in his case, D & D, Dungeons and Dragons.Kathryn de Bruin is an ICEEFT Certified EFT Trainer. Kathryn and Ronda are both licensed marriage and family therapists, EFT supervisors and therapists, and AAMFT Approved Supervisors.You can follow Kathryn de Bruin, LMFT atFacebook  YouTube  IG  Yelp  Google +  Twitter  WebsiteYou can follow Ronda Evans, LMFT atFacebook   Facebook   IG  WebsiteYou can follow Riley Fairgrieve, LPC, NCC atOther resources mentioned in this episode:The Kids Table (Videos of one family playing DnD): https://youtu.be/xSUgl6BHj0g?si=g99ObOl7GaXM2HeQRoll in the Family (Family Friendly Charity Event where 3 sets of parents and their kids played with a masterclass GM): https://youtu.be/4xnfQ4KjfSg?si=gBTjPVqx9UYEzypI

Proudly sponsored by PyMC Labs, the Bayesian Consultancy. Book a call, or get in touch!Intro to Bayes Course (first 2 lessons free)Advanced Regression Course (first 2 lessons free)Our theme music is « Good Bayesian », by Baba Brinkman (feat MC Lars and Mega Ran). Check out his awesome work!Visit our Patreon page to unlock exclusive Bayesian swag ;)Takeaways:DADVI is a new approach to variational inference that aims to improve speed and accuracy.DADVI allows for faster Bayesian inference without sacrificing model flexibility.Linear response can help recover covariance estimates from mean estimates.DADVI performs well in mixed models and hierarchical structures.Normalizing flows present an interesting avenue for enhancing variational inference.DADVI can handle large datasets effectively, improving predictive performance.Future enhancements for DADVI may include GPU support and linear response integration.Chapters:13:17 Understanding DADVI: A New Approach21:54 Mean Field Variational Inference Explained26:38 Linear Response and Covariance Estimation31:21 Deterministic vs Stochastic Optimization in DADVI35:00 Understanding DADVI and Its Optimization Landscape37:59 Theoretical Insights and Practical Applications of DADVI42:12 Comparative Performance of DADVI in Real Applications45:03 Challenges and Effectiveness of DADVI in Various Models48:51 Exploring Future Directions for Variational Inference53:04 Final Thoughts and Advice for PractitionersThank you to my Patrons for making this episode possible!Yusuke Saito, Avi Bryant, Giuliano Cruz, James Wade, Tradd Salvo, William Benton, James Ahloy, Robin Taylor, Chad Scherrer, Zwelithini Tunyiswa, Bertrand Wilden, James Thompson, Stephen Oates, Gian Luca Di Tanna, Jack Wells, Matthew Maldonado, Ian Costley, Ally Salim, Larry Gill, Ian Moran, Paul Oreto, Colin Caprani, Colin Carroll, Nathaniel Burbank, Michael Osthege, Rémi Louf, Clive Edelsten, Henri Wallen, Hugo Botha, Vinh Nguyen, Marcin Elantkowski, Adam C. Smith, Will Kurt, Andrew Moskowitz, Hector Munoz, Marco Gorelli, Simon Kessell, Bradley Rode, Patrick Kelley, Rick Anderson, Casper de Bruin, Michael Hankin, Cameron Smith, Tomáš Frýda, Ryan Wesslen, Andreas Netti, Riley King, Yoshiyuki Hamajima, Sven De Maeyer, Michael DeCrescenzo, Fergal M, Mason Yahr, Naoya Kanai, Aubrey Clayton, Omri Har Shemesh, Scott Anthony Robson, Robert Yolken, Or Duek, Pavel Dusek, Paul Cox, Andreas Kröpelin, Raphaël...

Martin Burns, CEO of Bruin Biometrics, is focused on preventing pressure injuries, which are often not detected through visual and tactile assessments because damage starts invisibly under the skin. The Bruin scanner technology identifies pressure injuries by measuring sub-epidermal moisture, which can predict later tissue death, highlighting the condition that can be treated before it develops further. This handheld device is skin tone agnostic, addressing a significant health disparity and providing an objective number indicating the presence of excess fluid, allowing clinicians to act quickly. Martin explains, "They are surprisingly common, and I emphasize surprisingly because pressure injuries are typically not talked about in the mainstream, but actually they affect about three to three and a half million patients a year in the US. And really shockingly, of those three to three and a half million, about 60,000 people die from them every year. So think about that as in the list of the top 10 leading causes of mortality in the United States, which is the surprising part. When you speak to friends and relatives, they've often heard of them potentially as bedsores, but nobody really has an appreciation of just how significant they are. How widespread or how deadly."   "The initial stages of it are imperceptible to any practitioner, but are actually measurable by objective technologies, and they don't become visibly manifest or physically manifest until much later. And what happens is they end up breaking the skin surface. As you can imagine, every time the skin is broken is an opening for infections and significant complications, which actually is the thing that ends up causing huge amounts of additional lengths of stay and costly treatments. And to the extent that those don't work, mortality." "Thankfully, our scanner is one in which the mechanism it uses disregards skin tone entirely. In other words, skin color doesn't matter for the scanner. What we are measuring is an increase or a decrease in fluid at the specific site that we're measuring. And so it's skin tone agnostic, which is rather brilliant because dark skin tone patients die at a rate four times more than any other cohort, which is an absolute travesty and one in which it simply doesn't need to happen. And our scanner is a leading reason why it doesn't need to happen." #BruinBiometrics #Prevention #PressureInjuries #HospitalSafety #PressureInjuryPrevention #PatientSafety #Hospitals bruinbiometrics.com Download the transcript here

Martin Burns, CEO of Bruin Biometrics, is focused on preventing pressure injuries, which are often not detected through visual and tactile assessments because damage starts invisibly under the skin. The Bruin scanner technology identifies pressure injuries by measuring sub-epidermal moisture, which can predict later tissue death, highlighting the condition that can be treated before it develops further. This handheld device is skin tone agnostic, addressing a significant health disparity and providing an objective number indicating the presence of excess fluid, allowing clinicians to act quickly. Martin explains, "They are surprisingly common, and I emphasize surprisingly because pressure injuries are typically not talked about in the mainstream, but actually they affect about three to three and a half million patients a year in the US. And really shockingly, of those three to three and a half million, about 60,000 people die from them every year. So think about that as in the list of the top 10 leading causes of mortality in the United States, which is the surprising part. When you speak to friends and relatives, they've often heard of them potentially as bedsores, but nobody really has an appreciation of just how significant they are. How widespread or how deadly."   "The initial stages of it are imperceptible to any practitioner, but are actually measurable by objective technologies, and they don't become visibly manifest or physically manifest until much later. And what happens is they end up breaking the skin surface. As you can imagine, every time the skin is broken is an opening for infections and significant complications, which actually is the thing that ends up causing huge amounts of additional lengths of stay and costly treatments. And to the extent that those don't work, mortality." "Thankfully, our scanner is one in which the mechanism it uses disregards skin tone entirely. In other words, skin color doesn't matter for the scanner. What we are measuring is an increase or a decrease in fluid at the specific site that we're measuring. And so it's skin tone agnostic, which is rather brilliant because dark skin tone patients die at a rate four times more than any other cohort, which is an absolute travesty and one in which it simply doesn't need to happen. And our scanner is a leading reason why it doesn't need to happen." #BruinBiometrics #Prevention #PressureInjuries #HospitalSafety #PressureInjuryPrevention #PatientSafety #Hospitals bruinbiometrics.com Listen to the podcast here

Jake is running for charity! If you would like to support his effort, donate HERE: https://fundraisers.hakuapp.com/wbjakeJake is running in the Rose Bowl Half-Marathon in January 2026 and would love to raise money for the McCourt Foundation (TMF). TMF raises money to fight neurological diseases like MS and Alzheimer's. The What's Bruin Show is happy to raise funds for this worthy charitable endeavor!Enjoy the What's Bruin Show Network!Multiple shows to entertain you on one feed:Support WBS at Patreon.com/WhatsBruinShow for just $2/month and get exclusive content and access to our SLACK channel.Twitter/X: @whatsbruinshow        Instagram: @whatsbruinshowCall the What's Bruin Network Hotline at 805-399-4WBS (Suck it Reign of Troy)We are also on YouTube HEREGet Your WBSN MERCH - Go to our MyLocker Site by Clicking HEREWhat's Bruin Show- A conversation about all things Bruin over drinks with Bruin Report Online's @mikeregaladoLA, @wbjake68 and friends!Subscribe to the What's Bruin Show at whatsbruin.substack.comEmail us at: whatsbruinshow@gmail.comTweet us at: @whatsbruinshowWest Coast Bias - LA Sports (mostly Lakers, Dodgers and NFL) with Jamaal and JakeSubscribe to West Coast Bias at wbwestcoastbias.substack.comEmail us at: WB.westcoastbias@gmail.comTweet us at: @WBwestcoastbiasThe BEAR Minimum - Jake and his Daughter Megan talk about student life and Cal Sports during her first year attending UC Berkeley.Subscribe to The BEAR Minimum at thebearminimum.substack.comEmail us at: wb.bearminimum@gmail.comTweet us at: @WB_BearMinimumPlease rate and review us on whatever platform you listen on.

JCO Editor-in-Chief Dr. Jonathan Friedberg is joined by colleagues Dr. Jennifer Woyach, Dr. Wojciech Jurczak, and Dr. Matthew Davids to discuss simultaneous publications presented at ASH 2025 on pertibrutinib, a new upfront treatment option for patients with chronic lymphocytic leukemia. TRANSCRIPT The disclosures for guests on this podcast can be found in the show notes. Dr. Jonathan Friedberg: I'm Jonathan Friedberg, editor of Journal of Clinical Oncology, and welcome to JCO After Hours, where we are covering two manuscripts that were presented at the American Society of Hematology meeting 2025 in Orlando, Florida. I am delighted to be joined by colleagues on this call to discuss these pivotal manuscripts which cover the topic of pirtobrutinib, a new upfront treatment option for patients with chronic lymphocytic leukemia. I will first just introduce our guests, Dr. Woyach. Dr. Jennifer Woyach: Hi, my name is Jennifer Woyach. I am from the Ohio State University. Dr. Wojciech Jurczak: Hello, I am Wojciech Jurczak, working at the National Research Institute of Oncology in Krakow, Poland. Dr. Matthew Davids: Hi, I am Matthew Davids from Dana-Farber Cancer Institute in Boston. Dr. Jonathan Friedberg: We are going to start by just learning a little bit about these two trials that were both large, randomized phase 3 studies that I think answered some definitive questions. We will start with your study, Jennifer. If you could just describe the design of your study and the patient population. Dr. Jennifer Woyach: Absolutely. So this is the BRUIN CLL-314 study, and this is a phase 3 randomized trial of pirtobrutinib versus ibrutinib in patients with CLL or SLL who had not previously been treated with a covalent BTK inhibitor. The patients were both treatment-naive and relapsed/refractory, about one-third of the patients treatment-naive, the rest relapsed/refractory, and they were stratified based upon 17p deletion and the number of prior lines of therapy. The primary objective was looking at non-inferiority of overall response rate over the entire treated population as well as the relapsed/refractory patient population. Key secondary objectives included progression-free survival in the intention-to-treat and the smaller relapsed/refractory and treatment-naive populations. Dr. Jonathan Friedberg: And just comment a little bit on the risk of the patients. Dr. Jennifer Woyach: This study was fairly typical of this cohort of patients. Within the relapsed/refractory patient population, there was a median of one prior line of therapy in each of the groups, up to nine prior lines of therapy in the patients included on the study. For the overall cohort, about two-thirds of the patients were IGHV unmutated, about 15% had 17p deletion, 30% had TP53 mutations, and about 35% to 40% had a complex karyotype, which is three or more abnormalities. Dr. Jonathan Friedberg: And what were your findings? Dr. Jennifer Woyach: Regarding the primary outcome, which is the focus of the publication, we did find that pirtobrutinib was indeed non-inferior and actually superior to ibrutinib for overall response rate throughout the entire patient population and in both the relapsed/refractory and treatment-naive cohorts. PFS is a little bit immature at this time but is trending towards also being significantly better in pirtobrutinib-treated patients compared with ibrutinib-treated patients. Probably most significantly, we found this to be the case in the treatment-naive cohort where there was a striking trend to an advantage of pirtobrutinib versus ibrutinib. Dr. Jonathan Friedberg: And the follow-up that you have on that progression-free survival? Dr. Jennifer Woyach: So we have about 18 months follow-up on progression-free survival. Dr. Jonathan Friedberg: The second study, Wojciech, can you just go through the design and patient population that you treated? Dr. Wojciech Jurczak: Thank you, Dr. Friedberg, for this question. So the BRUIN CLL-313 study was, in fact, the first phase 3 study with pirtobrutinib in exclusively untreated CLL patients. It was a randomized study where we challenged pirtobrutinib versus bendamustine-rituximab. At the time we designed the protocol, bendamustine-rituximab was an option as a standard of care, and Bruton tyrosine kinase monotherapy was used far more commonly than nowadays. The primary target of the study was progression-free survival. We took all untreated patients except for those with 17p deletions. Therefore, it is a good representation for intermediate risk. We had about 60% of the population, 56 to be precise, which was unmutated, evenly distributed into two treatment arms. 17p deleted cases were excluded, but we had about 7% and 8% of TP53 mutated patients as well as about 11% and 7%, respectively, in the pirtobrutinib and bendamustine-rituximab arm of patients with complex karyotype. The progression-free survival was in favor of pirtobrutinib and was assessed by an independent review committee. What is important is that the progression-free survival of the bendamustine-rituximab arm was actually similar to the other studies addressing the same questions, like the comparison with ibrutinib in the ALLIANCE study or zanubrutinib in the SEQUOIA study. What was different was the hazard ratio. In our study, it was 0.20. It was one of the longest effect sizes noted in the frontline BTK study. It represented an 80% reduction in progression-free survival or death. If we compare it to ibrutinib or zanubrutinib, it was 0.39 and 0.42 respectively. Presumably, this great effect contributed towards a trend of overall survival difference. Although survival data are not mature enough, there is a clear trend represented by three patients we lost in the pirtobrutinib arm versus 10 patients lost in the bendamustine-rituximab arm. This trend in overall survival is becoming statistically significant despite the fact that there was a possibility of crossover, and effectively 52.9 patients, which means 18 out of 34 patients relapsing in the bendamustine-rituximab arm, were treated by pirtobrutinib. Dr. Jonathan Friedberg: I am going to turn it over to Matt. The question is: why study pirtobrutinib in this patient population? And then with these two studies, how do you find the patients that were treated, are they representative of people who you see? And do you see this maybe being approved and more widely available? Dr. Matthew Davids: I think in terms of the first question, why study this in a frontline population, we have seen very impressive data with pirtobrutinib in a very difficult-to-treat population of CLL patients. This was from the original BRUIN phase 1/2 study where most of the patients had at least two or three lines of therapy, often both a covalent BTK inhibitor and the BCL2 inhibitor venetoclax, and yet they were still responding to pirtobrutinib. The drug was also very well tolerated in that early phase experience. And actually, we have seen phase 3 data from the BRUIN 321 study comparing pirtobrutinib to bendamustine and rituximab in a relapse population as well. So I think that really motivated these studies to look at pirtobrutinib as a first therapy. You know, often in other cancers of course, we want to use our best therapy first, and I think these studies are an initial step at looking at that. In terms of the second question around the patient population, these are pretty representative patient populations, I would say, for most frontline CLL studies. We see patients who are a bit younger and fitter than sort of the general population of CLL patients who are treated in clinical practice, and I think that is true here as well. Median age in the sort of mid-60s here is a bit younger than the typical patients we are treating in practice. But that is not different from other CLL frontline studies that we have seen recently, so I think it makes it a little bit easier as we kind of think across studies to feel comfortable that these are relatively similar populations. Dr. Jonathan Friedberg: How do you see this either getting regulatory approval or potentially being used compared to current standard of care options? Dr. Matthew Davids: So my understanding is that both of these trials were designed with registrational intent in the frontline setting, and they are both positive studies. That is certainly very encouraging in terms of the potential for an approval here. We have seen in terms of the FDA recently some concerns around the proportion of patients who are coming from North America, and my understanding is that is relatively low on these two studies. But nonetheless, the datasets are very impressive, and so I think it is certainly supportive of regulatory approval for frontline pirtobrutinib. Dr. Jonathan Friedberg: I will ask Jennifer a question. The control arm in your study was ibrutinib, and I think many in the audience may recognize that newer, second-generation BTK inhibitors like acalabrutinib and zanubrutinib are more frequently used now if monotherapy is decided. How do you respond to that, and how would you put your results in your pirtobrutinib arm in context with what has been observed with those agents? Dr. Jennifer Woyach: Yeah, that is a great question. Even though in the United States we are predominantly using acalabrutinib or zanubrutinib when choosing a monotherapy BTK inhibitor, this is actually not the case throughout the entire world where ibrutinib is still used very frequently. The head-to-head studies of both acalabrutinib and zanubrutinib compared to ibrutinib have shown us pretty well what the safety profile and efficacy profile of the second-generation BTK inhibitors is. So even though we do not have a head-to-head study of acalabrutinib or zanubrutinib versus pirtobrutinib, I think, given the entirety of data that we have with all of the covalent BTK inhibitors, I think we can safely look at the pirtobrutinib arm here, how the ibrutinib arm compares or performs in context with those other clinical trials. And though we really can not say anything about pirtobrutinib versus acalabrutinib or zanubrutinib, I think we can still get a good idea of what might be the clinical scenarios in which you might want to choose pirtobrutinib. Dr. Jonathan Friedberg: And Wojciech, do you agree with that? Obviously, I think you have acknowledged that chemoimmunotherapy is rarely used anymore as part of upfront treatment for CLL. So, I guess a similar question. If you were to put the pirtobrutinib result in your study in context with, I guess, more contemporary type controls, would you agree that it is competitive? Dr. Wojciech Jurczak: Well, I think that that was the last study ever where bendamustine-rituximab was used as a comparator arm. So we should notice that smashing difference. Because if we look at the progression-free survival at two years, we have 93.4% in pirtobrutinib arm versus 70.7% in bendamustine-rituximab arm. Bendamustine-rituximab arm did the same as in the other trials, like ALLIANCE or SEQUOIA. Pirtobrutinib did exceptionally well, as pirto is not just the very best BTK inhibitor overcoming the resistance, but perhaps even more important for the first line, it is very well tolerated and is a very selective drug. Now, if we look at treatment-related adverse events, the discontinuation rate, they were hardly ever seen. If we compared the adverse events in exposure-adjusted incidence, literally all adverse events were two or three times higher in bendamustine-rituximab arm except for the bleeding tendency, which however was predominantly in CTCAE grade 1 and 2 with just 0.7% of grade 3 hemorrhage. Therefore, I think that we should actually put the best and the safest drugs upfront if we may, and pirtobrutinib is, or should be, the first choice if we choose monotherapy. Now, I understand that we are not presenting you the data of pirtobrutinib in combination with anti-CD20 or with BCL2 inhibitors, but that is to come. Dr. Jonathan Friedberg: Matt, how would you envision, were regulatory approval granted and this were an option, using this in the upfront patient population? Is there anybody who you would preferentially use this or start on this treatment? Or would this be something that you would tend to reserve for second line? Dr. Matthew Davids: So I would say that in general for most of my patients who would want to start with a continuous BTK inhibitor, I would still use a covalent BTK inhibitor, and I say that for a couple of reasons despite the very promising data from these studies. The first is that the follow-up for both of these phase 3 trials is still quite short, in the range of a median 18 to 24 months. And we know that CLL is a marathon, not a sprint, and these patients are going to probably be living for a very long time. And we do have much longer follow-up from the covalent BTK inhibitors, median of 10-year follow-up with ibrutinib and five to six years with zanubrutinib and acalabrutinib respectively. And you know, I do not think that the pirtobrutinib is going to fall off a cliff after two years, but on the other hand, I think there is a lot of value to long-term data in this disease, and that is why I think for most of my patients I would stick with covalent BTK inhibitors. But the other important factor that we need to consider is patients who are younger and may have many different CLL treatments over the years. We have to be very careful, I think, about how we sequence these drugs. We know right now that we can start with covalent BTK inhibitors and then subsequently patients will respond well to the non-covalent inhibitor pirtobrutinib in later lines of therapy. But right now we do not have prospective data the other way around. So how will the patients on these studies who progress on pirtobrutinib respond to covalent BTK inhibitors? We do not know yet. There have not been a lot of progression events, which is great, but we would like to see some data in that respect to feel more comfortable with that sequence. Now, I do think that particularly for older patients and those who have significant cardiovascular comorbidities, if they wanted to go on a continuous BTK inhibitor, I do think these data really strongly support using pirtobrutinib as the BTK inhibitor of choice in that population. In particular, the cardiovascular risks with pirtobrutinib seem to be quite low. I was very struck in the comparison with BR that the rate of AFib was equivalent between the two arms of the study. And that is really the first time we have seen that with any of these BTK inhibitors, no elevated risk of AFib in a randomized study. I think that is the population where it will get the most traction first, is the upfront, sort of older patient with significant cardiovascular comorbidities. And as the data from these studies mature, I think that we will start to see more widespread use of pirtobrutinib in the frontline setting. Dr. Jonathan Friedberg: Jennifer, I am just curious if you have any personal experience or heard anecdotally about after progression on pirtobrutinib the use of other BTK inhibitors and whether there is a growing experience there. Dr. Jennifer Woyach: I do not think that there is much clinical experience, you know, as Matt alluded to, it certainly has not been tested yet. There has been some data in relapsed CLL suggesting that in people who have resistance mutations to covalent BTK inhibitors after treatment with pirtobrutinib, sometimes those mutations go away. I think most of us are concerned that they are probably not actually gone but maybe in compartments that we just have not sampled, suggesting that sort of approach where you might sequence a covalent inhibitor after a non-covalent in somebody who had already been resistant probably would not work that well. But, you know, in this setting where people had never been exposed to a covalent BTK inhibitor before, we really have no idea what the resistance patterns are going to be like. We assume they will be the same as what we have seen in relapsed CLL, but I think we just need some longer follow-up to know for sure. Dr. Wojciech Jurczak: If I may confront Dr. Davids about the use of covalent BTK inhibitors upfront, well, I think that we should abandon the idea of using the first and the second and the third generation, at least if we don't have medical lines. If we endlessly block the same pathway, it is not going to be effective. So if pirtobrutinib gets approval in first, second line, we do not necessarily have to use it in the first line. I am not here in a position to defend that we should treat patients with pirtobrutinib upfront and not BCL2 time-limited regimen. However, the way I look at CLL patients when choosing therapy is not just how should I treat them now, but what would be the best regimen in 5, 10 years if I have to re-treat them. And in some instances, the idea may be that in this setting we would like to have a BTK inhibitor upfront to have a BCL2 inhibitor later to make it time-limited. Although I understand and I agree with Matthew that if we have an elderly, fragile population, then the charm of having a drug taken once a day in a tablet with literally few cardiovascular adverse events might be an option. Dr. Jonathan Friedberg: And I will give Matt the last word whether he wants to respond to that, and also just as a forward-looking issue, I know both investigators have implied that there will be future studies looking at combinations with pirtobrutinib, and if you have any sense as to what you would be looking for there. Dr. Matthew Davids: The field really is heading toward time-limited therapy for most patients, I would say. There is a bit of a discrepancy right now in the field between sort of what we are doing in academic practice and what is done sort of more widely in community practice. And so right now we are going to see evolving datasets comparing these approaches. We are already seeing data now from the CLL17 study with ibrutinib comparing continuous to time-limited venetoclax-based therapy, and we are seeing similar efficacy benefits from these time-limited therapies without the need for continuous treatment. And so that is where I think some of the future studies with pirtobrutinib combining it with venetoclax and other partners are so important. Fortunately, several of these studies are already ongoing, including a phase 3 trial called CLL18, which is looking at pirtobrutinib with venetoclax, comparing that to venetoclax and obinutuzumab. So I am optimistic that we are going to be developing these very robust datasets where we can actually use pirtobrutinib in the frontline setting as a time-limited therapy as a component of a multi-drug regimen. So far, those early data are very promising. Dr. Wojciech Jurczak: Perhaps last but not least, in a single center we have treated over 300 patients with pirtobrutinib. So eventually some of them relapsed. And I must say that our experience on BCL2 inhibitors, not just venetoclax but including sonrotoclax, are appealingly good. Therefore, by using pirtobrutinib even earlier, we do not block the efficacy of other compounds. Dr. Jonathan Friedberg: All right. Well, I want to thank all of our speakers. I also want to congratulate our two guests who presented these very influential papers at the ASH Annual Meeting, and chose to publish them in JCO, so we thank you for that, and Dr. Davids for your commentary - really appreciated. That is this episode of JCO After Hours. Thank you for your attention. The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement.   Disclosures Dr. Wojciech Jurczak Consulting or Advisory Role: BeiGene, Lilly, Abbvie/Genentech, Takeda, Roche, AstraZeneca Research Funding: Roche, Takeda, Janssen-Cilag, BeiGene, AstraZeneca, Lilly, Abbvie/Genentech Dr. Jennifer Woyach Consulting or Advisory Role: Pharmacyclics, Janssen, AstraZeneca, Beigene, Loxo, Newave Pharmaceutical, Genentech, Abbvie, Merck Research Funding: Company name: Janssen, Schrodinger, beone, Abbvie, Merck, Loxo/Lilly Dr. Matthew Davids Honoraria: Curio Science, Aptitude Health, Bio Ascend, PlatformQ Health, Plexus Consulting or Advisory Role: Genentech, Janssen, Abbvie, AstraZeneca, Adaptive Biotechnologies, Ascentage Pharma, BeiGene, Lilly, Bristol-Myers Squibb, Genmab, Merck, MEI Pharma, Nuvalent, Inc., Galapagos NV, Schroedinger Research Funding: Ascentage Pharma, Novartis, MEI Pharma, AstraZeneca  

Bruin fans, there's a LOT going on with UCLA athletics and we're here to discuss some key happenings around the Bruinverse. First and foremost, football has had a topsy turvy week and we talk about the rivalry loss, Tim Skipper and the job he did and last, but not least, Bob Chesney, the next head football coach of UCLA. We also discuss hoops and MBB's big L to Cal, why this week for them is key and WBB's loss to Texas and rebound against Tennessee. Check it all out right here!

Who left a whole box of corn flakes In a locker At the Equinox On Wall Street? I told you go to the one at The Rock. I told you, I'm not going on that block, like at all. {Enter The Multiverse} That's just my Karma, Ms. Nancy; I did a whole lot than just Thought about it More edits, More recognition that I—l couldn't stand it; The planet just seems to get smaller and smaller With less and less plants in it; I have your pants on, But shoes didn't fit I wrote a whole book and resenting But still not the movies, I meant it. Damn. She's just so much better than I am Head in a frying pan on high beforehand, And however damaged, It felt bad I know what I did I felt that Camera Obscura, for sure, you know But disconnect, Swallow badders, wha— t?! Get my peanut butter up; Why! I'm a circus monkey; Damn. I got karma faster Than I should have known I lost episodes And threw away the whole entire show I went running long And then I threw up on the subway I only like the one Sublime album (The one with wrong way.) You know? Cuh' I went the wrong way I fucked up on all my dollars I got karma back hard, yah Got a poem or prose or song on ol' Ms. Molly, too, (or two) I fall in love inside the tube, Truth is, though Teletubbies and teleportation Ain't so far off from where I come from Problem is, Opporsite world, I'm the story of the whole show; For sure dawg. —a situational Thought process. When the crack finally kicks in, Astounding the loss of my confidence I've gotten lost in a toxic land I got syndrome “talk to much” Not on the spectrum, nor diagnosable X's and O's on the tic tac toe board, Just an underhanded “I told you so” All the rockstars want —Subtle thoughts of suicide as the train approaches? Nah, Models and the other types of girls That never work at all, They just born at it. I got bored with it, But not the fourth one, Cross my first amendment, On my heart like catholic More like Bart Simpsons, Like art magic Cause I won't watch that show But love Matt Groening— Maybe I'm the type that just Love hating But hate loving with No way to I don't hate you; Yeah you're right, I'm off Take two. ((Good Luck Riding The J Home.)) Not a gym run, a different kind of cause, I guess I got so many plausible options, I guess I should call on one of them, Toss a number up, struck the dog on mathematics I can't let my lantern out of gas, We're not friends, are we? What a fiend! Are you offended? I just want to see my dreams relayed to me— Is that too much to ask? So I'm the asshole. What did I pack a bag for?! Picnic baskets. What did I leave this curse for? Nothing, Thanks for asking, Nance. I put a pilot on the presence of a whole color— phenomenon. I swallowed all my pride and presence just for an automaton. This automation algorithm— is it? Doesn't make a difference. I spilled blood inside my kitchen, Put deposits on a flicker, Tricked the treasure at a phantom, Phantom I want more but swallowed all my high pulp orange juice on knowledge of the only one; There's only God, There's only us— There's only cause+ effect, 6 more albums, note books and a couple novels that came out of that one. Squeeze em hard, ya'll. Don't let me love God. Don't let me talk back, I'm not about a rack. Tantrum, yes. Talk to my God. Please. Talk to me God. Now. Talk to my family one time. Now. Talk out me sideways— Now. Bring me a rebel. Now. I have a headache. Now. I got regrets son. Now I got a dead son, a dead daughter a ghost cat and George Jettson, Michael Jackson and George Zimmerman, all of my tabs open: I take a tab hoping I fall asleep on the cold ocean, Calm before storm comes Out on a surfboard Look at the full moon— Nobody can hear you so SCREAM. Now. For crying out loud, Take the knife out, For a second or thought, I'm a wife now; What back handed thought or a back and on blacklist— Your back room was only your conscious— Now I'm looking at my left side, Also catatonic, Not aboard the problem like you wanted, What an order form for border patrol, You want tall glasses of hard fortune, Work hard for it, or rosemary pork on sourdough. I'm in love with you, but in poverty— There the devil is. But oh, aren't we all familiar? Suit and tie hangs to the tide, I tie the knot with rope from which I die, And quickly crafting coffins, want to walk around before I go off, Diving board or world one antenna? Not to mention it, redirect the attention and energy into something other than consumptive— Everything I do and everywhere I go, I clutch this stone Or put inside my pockets knowing if I let it go Or it falls out and to the ground Not only will I float up, But the world will open And swallow us all whole ((Down.)) I live with the knowledge of criminal visions and masterpiece compilations, but as of today I owe a bank my very and entire existence It is what it claims to be, these days ring true Nothing these days sounds like music but you. I put that book back on the shelf; Rewound the tape before I put it in the case I knew it would be late because, well That's the way it always is That's the way I always am I'm sorry mom. That's the way it always is— They told me I don't need no makeup on, However this may have only been true when I was ten to twenty two, Or twenty two, Or two whole years ago before the motorcycles stole my story. When I put the sun up in the sky, I suppose, is when I started this [that's called a God Complex] It's all behind us now, or rather All up front And out in the open In twelve point font As if I would ever cop to it I took the wrong way to Wall Street l Believe me l, i think of the tree at the rock, Long before this all was ever thought of, And I held her seed in the heart of my palm God said go the other way, I said “Okay” I want to see how much money I make; I wear makeup, I got nothing So much for a body I got stuck with words and good talking, And long vocabulary instead of the coast and a longboard So what's the cost for a whole table turn? So what's the cost for a “her—perfect.” Huh? What is the cost for some popcorn in Lorne's office? What is the cost just to cover the love boat theme song— Don't get me wrong I have original music I'm just hard getting to it; The motors are running The mirror: my mind is a murderer, murderer Engine's are purring are hurting her, hurting But I been wanting some corn on the cob To talk to my mom To call some place home To care for my son To wake up on Sunday past noon like “That was a good show.” And the next sold out . real talk, I got real problems Someone knows I'm on top of my thoughts at the rock, Choking back cocaine All the world under me, Mad at the world though For not looking up to me Huh I call this suffering Cause I already been been hungry, And homeless So I know this Pit-of-your stomach And tied to a brick at the bottom of the ocean feeling, that really Sits somewhere between “Hopeless” And “not good” But hey— If you were to say “how's your day” I answer “I'm great!” Like a positive, programmed robot or something, my mantras lately, replaced however with repetitive honest pleas of “Please help me.” Seems like— the only thing meaningful is saying this inside my Google documents; However, Seems like, It isn't worth the breathing, really Oddly, I forget to— Then I get this special feeling, Almost sentimental, inside my head I don't need medicine as much as I just need a friend besides my cat —thoughts of hammers in my brain— If I could tell you what the level of the pain is? Mercy. There doesn't seem to be a number Merry Christmas, Let's get displaced; Case is dismissed— Let's get shitfaced Wash the dishes, Pick the peloton, Pick imaginary friends And watch the President be hilarious, Until it effects us negative and in the read, When peanut butter bread and jelly All you ever get for breakfast For extended periods of time. Hah. Bloodshed? Wrong. Blood hound? Bad. Segmented thoughts on a toothache? Too late. I hate to tell you what the truth is, Cause you'd hate it. Useless. Jew fits; I just saved two cents on toothpaste And you got two new fits to wear for your friends approval and some cool picks But I can't do this anymore I want to choose live; Inside my death is The whole of the city, Electric and Thomas Edison And impressive Mister Business— Rockerfeller read about it; Somebody gotta learn and teach to squeeze the money out the people! Something simple says, “Just stop it.” Choke a chicken over breakfast, Thoughts of Belfast, real fast train to somewhere in LA, I think Today will be the day That I give bacon To charity, No care left, to give a gift So thankful, For being blessed with time to waste To write this piece of shit I guess I died I guess in family guy? I didn't like it, yet I think sometime's in stewie's cadence— …like, a British baby? And a talking dog? And a dumb ass dad? And a bunch of songs? And some salad dressing, To go with that master habit of getting Grams and Grammies; But in the long run, after a long talk on the roof with the opposite of God, I finally call a conference with all the lawyers of the court— But not to work at all, Only order sandwhiches Obsession has its advantages and platinum records, If you tap into it directly. Forget it. I'm out of magic. Or out of patience— out of time for petitions, But which one is it? Which dimension actually gets me picture perfect Instead of nervous in the eye of the beholders? Learn your lesson well; There's got to, got to be a reason why The wrong way is the right. There's got to be a reason why— My day becomes the night. There's got to be a reason for the words upon the paper, But I've got to figure out my rhythm later; I gone up instead of downtown, Turn the clock before the sunrise, I just want to find the love and the peace in it agai. Gotta love a synchronicity; I get stuck inside bronze statues Door way syndrome And I shutter just to never remember him But here the picture is, a perfect person Headless and befriended him, the lover The line inside my mind is crossed I'll suffer till I turn to dust on this one. My thoughts the first time I saw him? I hate him, Cause he'll never love me. What a troubled thought for a little girl on a lot of drugs and a weight problem. One more, I don't remember where I'm going Day to, I have to remember to forget you Take three, I'm happy that they pay me to tape these things Because I'm maybe going crazy; From the outside though, you wouldn't know it Low and behold, this is my show afterall And covered in gold like the whole of the moon I can play to the tune of two men, to two million don't let it torment you, You looks twisted Get out of your head, and turn off your television Go on a walk, Get run over by a bus or motorcycles Turn around and talk to God and your disciples — cause they all watch. Oh, what's wrong now? That's a long run, And now another pilot that I'm proud of— Stop looking at the ground— It hurts. Today, I learned my lesson, It was not a new apartment— It's a prison. I gotta say I kinda gotta love to wonder where the fuck I'm at besides “Manhattan”. The cat needs water, My heart needs captions. New York needs Jesus Hope he don't see this (Even if he did he probably wouldn't believe it, Or Even if he did He's having trouble learning English, And, Even if he did he had he's been repealing all his promises to return to us; We worship dollars A cock-shaped structures in New York— TIME TRAVELER Its called The Rock. SUPER NEW YORKER What. TIME TRAVELER I'm looking for The Rock. SUPER NEW YORKER What's that. TIME TRAVEL It's called “Rockefeller Plaza.” SUPER NEW YORKER What's that. TIME TRAVELER It's a building? I guess? SUPER NEW YORKER It's not. TIME TRAVELER It is. It's— SUPER NEW YORKER It's not. TIME TRAVELER But— *fucks off immidiately without any closure whatsoever.* TIME TRAVELER Huh. the TIME TRAVELER pulls up a picture on their device; the building itself seems to have disappeared from the photo; (Like Marty McFlyim back to the future) Contd Must be the wrong dimension… But then JOHN D. ROCKERFELLER Is MURDERED at the height of STANDARD OIL. Oh no! So that's what happened… Yeah? He was a bastard. Well! Damn. {Enter athe Multiverse} So you're everywhere all the time, And I got nothing left to run And we already talked the talk And we're already back to one Let the waves blow over, Cravings, tasting haze of periwinkle, heaven waking Putting every penny on the promise that you got me But you never save me, Really, Jesus? Racist! I got a lot of stakes in the game And all these snakes keep weighing in! I got these eight days left inside my head, And I'm a murderer Remember to admit his wrong you are Next time the caw will crow. I crevice drawing under rock Inside the undertoe, My surfboard heading home for shore, My body going under. Oh Conan, what have you done. I'm not sure yet. So? Go get him, you old hoot. I just want to watch a little longer! *feathers ruffled* What! It is comical So i'm stuck inside the equinox on Wall Street catatonic, Adding up the dollar signs and losses, Well now, Got my hosts and calling cards, And struck with dirty dozens Doesn't anybody understand? [no. Nobody does.] Certainly, you know, nobody does this. Certainly, I'm folding all the shirts for all the husbands Certainly my love was lost, but for sure I didn't want it. For sure, I dropped a couple rocks I had inside my pocket . Well done, folks. Guess what? Those aren't crocodile tears I'm crying. I'm dehydrated but they're called psychic cause Nobody knows where they come from; Some would form the thought that you got water trapped inside your soul It only happens when the sun sheds hard tears Here, solar panels Animals and tragic circumstances, Fucking Asholes Never shine your diamond on the twilight, Shooting stars; Never shoot at birds from cars; Remember, They are flying. I swallowed you whole, I swallowed you whole, I swallowed you, done. I swallowed you whole, I swallows you whole, I swallowed you down some. I swallowed you whole, I swallowed you whole, I swallowed you up; I swallowed you whole I swallowed you whole, You know what the cost is Just a heads up, If you take a picture of a gamgstalkers face, They run away. The crime being committed is a non-contact form of combat, a scientifically proven biological weapon. When you begin to document this meticulously, a pattern of coordination begins to become established. It's no longer some sort of phenomenon, that can be written off as a symptom of a broken mind; The more evidence you gather, It becomes a verifiable crime. Remember that the point of it is to control you, to enslave your autonomy— to program you to believe something is wrong, when clearly, The signs of an awakened mind can pick out patterns in the construct of human social behavior that is not ours; it is a deficit in conciousness, a weakness, caused by the moral degradation of our souls in the societal world— A loss of God. And also remember, Humans have a history to seek and destroy which it does not understand, And cannot control— However, also, God comes in all forms. You must know when all is all. Okay, shh— Don't lock the door, now You got a pardon, You better run. I am an a-list celebrity; I am an “amen, sister— I hear that!” I am a medicine woman, A centrifugal figure, A ritual character, Skilled at charicature— A big Kimmel fan, A rick and a Morty, A woman a man, A puppet, the master, A cat in a hatbox, A blasphemous coffin; A wart on a warflower. Hm. Now who could possibly take that out of context? Soft surf rock at the equinox on Wall Street. I love all four stories, I rode all four horses, I put all four corners of the earth onto a surface Then I rolled it up Huh… Somebody does that. Leets go, hard core But don't forget the hot sauce Don't forget the — Smattercat?! SMATTERCAT?! SMAAAAAATERCAAAAAAAAAT! The Adventures of Atticus Catticus. Man, this is fucked up. I can't disagree with you. I can't get you out of my head (I want head) Can't get you out of my mind I find that You must want me dead Tan lines l You must want me off my meds! You want in me in bed at 9 sharp You know what!? You remind me of Harper. Now let's talk shop, Calm, little brother I went with the other oath— Don't you belong to God? Who's on the phone? Donald Trump. Tell him “no.” No to what? Just tell him “no.” Then he'll get here faster. So what do you got in your supplements? Simple psychology; Have a red album. Nah that. I got gold gold balls on all of my prostitutes Pulled apart orgasms, Never been touched, sire. Never have I took forgranted this passion( Never have —that flex— Theatrical pangentry. Never went Ham sandwhich Ham sandwhich Ham sandwhich GODDAMMIT. I thought you grant wishes. — also in charge of summoning. Part time. Well what are you mad about?! At least you got a job! I'm so sick of this kid, He just summons “Ham sandwhich” What's wrong with that? I gave him “ham sandwhich”, Alright?! All kinds, And you know what? That guy has all kinds of magic— All the kinds— Every kind you can imagine, And no matter what, He just wants. Hmmmm…: …. Come on. Summon a dog, or something… A new bike… ……. ……..:::: ……. …. Ham sandwhich. GOD DAMMIT. …and a kite. …what was that? I want a kite. Y…you want to fly a kite. Ya. Alright! But first. An, God. Ham Sandwhich. WHAT THE FUCK ARE YOU DOING? SO WHAT I LOVED NANCY REGAN! SHE HAD THE BEST CATCHPHRASES! AND ALL THE KENNEDIES! FUCK WITH ME. Somebody shoot that bitch. But sir— Before she runs for president. But sir… THINK OF IT LIKE KILLING BABY HITLER. You're right. TAKE THE SHOOOOOT. MEANWHILE… In the MULTIDIMENTIONAL SPACETIME SURVEILANCE FACILITY Oh good. What's that. Someone one assasinated me. That's good. I'll say. Wouldn't want you to run for president. Someone still would have had to elected me. Oh, you mean like in all these parallels over here. *shrugs* They'll collapse eventually. They haven't yet. I just got assasinated. Wait for it. I've been waiting. I don't get why you hate me so much. I'm indifferent, really, just waiting for something exciting. I just got assasinated. And I just got a ten cent raise. From what I can tell, doesn't make much of a differences. It's like, limited assimilation in this dimension; Did I correct you— Lessons, I'm not making any promises. Look out little brother! I set them on you. Got to put the pudding in your pot— And don't forget to floss. What's corrextions? Look, I'm anatomically correct— Shut up, Ken. I don't click on videos or images Because I love him It's just a crush, A pair of wooden crutches A horcrux And a fox A crucifix And Sunday Brunches. It's just a bunch of pictures, Edits, autographs, Extended plays It's just an infinite inside my head— It's been a couple days. A couple miles down And sure to go, You're all for it— Soon you got to know Whatever you done Has come for your— Stop the truck for misuse of four muses And autotune to ruin it— Your mascot is a narwhal But you're rooting for the Bruins. What is even a Bruin? A bunch of racist frat boys and hot bitches in sororities and covens? Bet that Okay, Like, I fall in love But just to write a bit I pour my heart out in a song And for the moment I could make forget i'm ugly Even if for the duration of the half time; Half a pack at halftime, Half a pack at bedtime 20 cigarettes on your 2020 vision. Three beers, Then three beers Thirty three years and he still won't love me Thirty three years and I'm still no woman. He show first, So I shot back I forgot rock doves Served a purpose Postage For lost albums on the surface Surfboards For hot rod bod host, I offered up Conan, Now pick that hard eye Banjo up Water dance Pick that apple, Off the tree With not a scratch Hands tied behind your back; Baggage claim, River dance Pick it up without a fork You whispered us a state of trance For God's socks, If I fly coach, Low ball Lost a fortune Don't call me ‘bud' I think about your walk all day; Like, Three or four times, maybe Not no noodle soup, you wonder But you're asking for a Ballroom. Haggard. God did far too good a job on you; As the car jumped over the moon. I complete your meat puppet, But recently went vegan Line them up and then A heart attack, A hot bath, And a hammock. You got your offer, But I want it back, I want my roses. Golden proses so rit and rattle. I rot in hell for all I've done, then scramble; Damn. I just can't get you off my head without ramble You're probably on a tour bus; She's pulling out all the stop— But you're my monster, just know that Although I'm on top of her turf. So much for Service Monday. So much for making money on a conduit, a conduct. So much for love as. He aim for the head; I aim for the neck; He aim for the heart, I duck, I fall in her eyes, High water— No more cam tide Sunsets. What, I get you really wanted oceans, So you got them. Godsense. Pull, Conan Pull— Haul in! All in on your cards, But take the occult off them; Offering? Totem pole. More than one? I love to hope. Fix your face. Pull the plug— I'm off till Sunday, Off till Sunday. Ten days to Tuesday, You want no more Ten days to Sunday And ten more before that; Ten tongues before dawn, And other I slaughter And slaught cross the sloth, I wither, Your honor. Ten tales too soon, Ten wide my diamonds; Ten eyes in your Isis, My mind, Orion. Ten lost in the Outback; Ten lost on your mass, tongue Two whipped at the alter— I called her about that. So to the effect you check your fax and press the send, I'm steady living, never coming back, Or cap the president— Never living, Never listing residence on Madison You're stuck inside my half-life That I'm mad besides the medicine. You're stuck inside my past, Like all the knives inside my back, And still I fondly think upon a laugh, As ice cream sundaes, Half a sandwich Appetite for having all you are inside my master work of art, The world, your face I cut from clay inside my hands And I still have you in my swollen arteries, and trees the veins, The wicked summers and the bitter winters came, But did not cross paths, So to not bear ties, and to not plug Holes in the hull of the whole ship I think I sunk overtime instead of rather All at once, You know, It doesn't suffix What it takes to turn it back from “Love him” Into nothing. 20 hours passed and 20 cigarettes and ivory towers, But forgive the lives inside of Mormon wives and ice cold showers— Scatterbrained but highly trained in “Never Happened.” “Didn't matter.” So you roll it up into a movie script and call them actors. Why'd you flash me, dancer, Don't you know how bad I want that? Out inside your dozens, for my cinnamon coated combat Nail box fires Had you ordered Your desires Flow the golden drifter Fear of rivers never frozen. Don't you know the sun draws close But the heart grows cold, But the want goes harder? Don't you know the doors get shut, And the Kings get cut, And the wind blows wilder? Don't you know the stars just fall from the sky (They all fall from the sky, They fell from the sky) Don't you know We're all gonna die Put a trial to the wand, Fore you take her heart out Ten times.

Jake is running for charity! If you would like to support his effort, donate HERE: https://fundraisers.hakuapp.com/wbjakeJake is running in the Rose Bowl Half-Marathon in January 2026 and would love to raise money for the McCourt Foundation (TMF). TMF raises money to fight neurological diseases like MS and Alzheimer's. The What's Bruin Show is happy to raise funds for this worthy charitable endeavor!Enjoy the What's Bruin Show Network!Multiple shows to entertain you on one feed:Support WBS at Patreon.com/WhatsBruinShow for just $2/month and get exclusive content and access to our SLACK channel.Twitter/X: @whatsbruinshow        Instagram: @whatsbruinshowCall the What's Bruin Network Hotline at 805-399-4WBS (Suck it Reign of Troy)We are also on YouTube HEREGet Your WBSN MERCH - Go to our MyLocker Site by Clicking HEREWhat's Bruin Show- A conversation about all things Bruin over drinks with Bruin Report Online's @mikeregaladoLA, @wbjake68 and friends!Subscribe to the What's Bruin Show at whatsbruin.substack.comEmail us at: whatsbruinshow@gmail.comTweet us at: @whatsbruinshowWest Coast Bias - LA Sports (mostly Lakers, Dodgers and NFL) with Jamaal and JakeSubscribe to West Coast Bias at wbwestcoastbias.substack.comEmail us at: WB.westcoastbias@gmail.comTweet us at: @WBwestcoastbiasThe BEAR Minimum - Jake and his Daughter Megan talk about student life and Cal Sports during her first year attending UC Berkeley.Subscribe to The BEAR Minimum at thebearminimum.substack.comEmail us at: wb.bearminimum@gmail.comTweet us at: @WB_BearMinimumPlease rate and review us on whatever platform you listen on.

Jake is running for charity! If you would like to support his effort, donate HERE: https://fundraisers.hakuapp.com/wbjakeJake is running in the Rose Bowl Half-Marathon in January 2026 and would love to raise money for the McCourt Foundation (TMF). TMF raises money to fight neurological diseases like MS and Alzheimer's. The What's Bruin Show is happy to raise funds for this worthy charitable endeavor!Enjoy the What's Bruin Show Network!Multiple shows to entertain you on one feed:Support WBS at Patreon.com/WhatsBruinShow for just $2/month and get exclusive content and access to our SLACK channel.Twitter/X: @whatsbruinshow        Instagram: @whatsbruinshowCall the What's Bruin Network Hotline at 805-399-4WBS (Suck it Reign of Troy)We are also on YouTube HEREGet Your WBSN MERCH - Go to our MyLocker Site by Clicking HEREWhat's Bruin Show- A conversation about all things Bruin over drinks with Bruin Report Online's @mikeregaladoLA, @wbjake68 and friends!Subscribe to the What's Bruin Show at whatsbruin.substack.comEmail us at: whatsbruinshow@gmail.comTweet us at: @whatsbruinshowWest Coast Bias - LA Sports (mostly Lakers, Dodgers and NFL) with Jamaal and JakeSubscribe to West Coast Bias at wbwestcoastbias.substack.comEmail us at: WB.westcoastbias@gmail.comTweet us at: @WBwestcoastbiasThe BEAR Minimum - Jake and his Daughter Megan talk about student life and Cal Sports during her first year attending UC Berkeley.Subscribe to The BEAR Minimum at thebearminimum.substack.comEmail us at: wb.bearminimum@gmail.comTweet us at: @WB_BearMinimumPlease rate and review us on whatever platform you listen on.

Jake is running for charity! If you would like to support his effort, donate HERE: https://fundraisers.hakuapp.com/wbjakeJake is running in the Rose Bowl Half-Marathon in January 2026 and would love to raise money for the McCourt Foundation (TMF). TMF raises money to fight neurological diseases like MS and Alzheimer's. The What's Bruin Show is happy to raise funds for this worthy charitable endeavor!Enjoy the What's Bruin Show Network!Multiple shows to entertain you on one feed:Support WBS at Patreon.com/WhatsBruinShow for just $2/month and get exclusive content and access to our SLACK channel.Twitter/X: @whatsbruinshow        Instagram: @whatsbruinshowCall the What's Bruin Network Hotline at 805-399-4WBS (Suck it Reign of Troy)We are also on YouTube HEREGet Your WBSN MERCH - Go to our MyLocker Site by Clicking HEREWhat's Bruin Show- A conversation about all things Bruin over drinks with Bruin Report Online's @mikeregaladoLA, @wbjake68 and friends!Subscribe to the What's Bruin Show at whatsbruin.substack.comEmail us at: whatsbruinshow@gmail.comTweet us at: @whatsbruinshowWest Coast Bias - LA Sports (mostly Lakers, Dodgers and NFL) with Jamaal and JakeSubscribe to West Coast Bias at wbwestcoastbias.substack.comEmail us at: WB.westcoastbias@gmail.comTweet us at: @WBwestcoastbiasThe BEAR Minimum - Jake and his Daughter Megan talk about student life and Cal Sports during her first year attending UC Berkeley.Subscribe to The BEAR Minimum at thebearminimum.substack.comEmail us at: wb.bearminimum@gmail.comTweet us at: @WB_BearMinimumPlease rate and review us on whatever platform you listen on.

Jake is running for charity! If you would like to support his effort, donate HERE: https://fundraisers.hakuapp.com/wbjakeJake is running in the Rose Bowl Half-Marathon in January 2026 and would love to raise money for the McCourt Foundation (TMF). TMF raises money to fight neurological diseases like MS and Alzheimer's. The What's Bruin Show is happy to raise funds for this worthy charitable endeavor!Enjoy the What's Bruin Show Network!Multiple shows to entertain you on one feed:Support WBS at Patreon.com/WhatsBruinShow for just $2/month and get exclusive content and access to our SLACK channel.Twitter/X: @whatsbruinshow        Instagram: @whatsbruinshowCall the What's Bruin Network Hotline at 805-399-4WBS (Suck it Reign of Troy)We are also on YouTube HEREGet Your WBSN MERCH - Go to our MyLocker Site by Clicking HEREWhat's Bruin Show- A conversation about all things Bruin over drinks with Bruin Report Online's @mikeregaladoLA, @wbjake68 and friends!Subscribe to the What's Bruin Show at whatsbruin.substack.comEmail us at: whatsbruinshow@gmail.comTweet us at: @whatsbruinshowWest Coast Bias - LA Sports (mostly Lakers, Dodgers and NFL) with Jamaal and JakeSubscribe to West Coast Bias at wbwestcoastbias.substack.comEmail us at: WB.westcoastbias@gmail.comTweet us at: @WBwestcoastbiasThe BEAR Minimum - Jake and his Daughter Megan talk about student life and Cal Sports during her first year attending UC Berkeley.Subscribe to The BEAR Minimum at thebearminimum.substack.comEmail us at: wb.bearminimum@gmail.comTweet us at: @WB_BearMinimumPlease rate and review us on whatever platform you listen on.

Proudly sponsored by PyMC Labs, the Bayesian Consultancy. Book a call, or get in touch!Intro to Bayes Course (first 2 lessons free)Advanced Regression Course (first 2 lessons free)Our theme music is « Good Bayesian », by Baba Brinkman (feat MC Lars and Mega Ran). Check out his awesome work!Visit our Patreon page to unlock exclusive Bayesian swag ;)Takeaways:Ethan's research involves using lasers to compress matter to extreme conditions to study astrophysical phenomena.Bayesian inference is a key tool in analyzing complex data from high energy density experiments.The future of high energy density physics lies in developing new diagnostic technologies and increasing experimental scale.High energy density physics can provide insights into planetary science and astrophysics.Emerging technologies in diagnostics are set to revolutionize the field.Ethan's dream project involves exploring picno nuclear fusion.Chapters:14:31 Understanding High Energy Density Physics and Plasma Spectroscopy21:24 Challenges in Data Analysis and Experimentation36:11 The Role of Bayesian Inference in High Energy Density Physics47:17 Transitioning to Advanced Sampling Techniques51:35 Best Practices in Model Development55:30 Evaluating Model Performance01:02:10 The Role of High Energy Density Physics01:11:15 Innovations in Diagnostic Technologies01:22:51 Future Directions in Experimental Physics01:26:08 Advice for Aspiring ScientistsThank you to my Patrons for making this episode possible!Yusuke Saito, Avi Bryant, Giuliano Cruz, James Wade, Tradd Salvo, William Benton, James Ahloy, Robin Taylor, Chad Scherrer, Zwelithini Tunyiswa, Bertrand Wilden, James Thompson, Stephen Oates, Gian Luca Di Tanna, Jack Wells, Matthew Maldonado, Ian Costley, Ally Salim, Larry Gill, Ian Moran, Paul Oreto, Colin Caprani, Colin Carroll, Nathaniel Burbank, Michael Osthege, Rémi Louf, Clive Edelsten, Henri Wallen, Hugo Botha, Vinh Nguyen, Marcin Elantkowski, Adam C. Smith, Will Kurt, Andrew Moskowitz, Hector Munoz, Marco Gorelli, Simon Kessell, Bradley Rode, Patrick Kelley, Rick Anderson, Casper de Bruin, Michael Hankin, Cameron Smith, Tomáš Frýda, Ryan Wesslen, Andreas Netti, Riley King, Yoshiyuki Hamajima, Sven De Maeyer, Michael DeCrescenzo, Fergal M, Mason Yahr, Naoya Kanai, Aubrey Clayton, Omri Har Shemesh, Scott Anthony Robson, Robert Yolken, Or Duek, Pavel Dusek, Paul Cox, Andreas Kröpelin, Raphaël R, Nicolas Rode, Gabriel Stechschulte, Arkady,

Welcome back for the next journey of The Family Express Podcast with Kathryn de Bruin, LMFT and Ronda Evans, LMFT where our destination is resilient and connected families. Our guest today is Dr. Kade Sharp who will speak about spotting the signs of autism spectrum disorder and starting the conversation with families.Kathryn de Bruin is an ICEEFT Certified EFT Trainer. Kathryn and Ronda are both licensed marriage and family therapists, EFT supervisors and therapists, and AAMFT Approved Supervisors.You can follow Kathryn de Bruin, LMFT atFacebook  YouTube  IG  Yelp  Google +  Twitter  WebsiteYou can follow Ronda Evans, LMFT atFacebook   Facebook   IG  WebsiteYou can follow Dr. Kade Sharp atSpectrum Counseling: www.kadesharp.comOther resources in this episode:Curious Cryptid Learning (continuing education platform): www.cryptidlearns.com@cryptidlearns on Facebook and Instagram

Jake is running for charity! If you would like to support his effort, donate HERE: https://fundraisers.hakuapp.com/wbjakeJake is running in the Rose Bowl Half-Marathon in January 2026 and would love to raise money for the McCourt Foundation (TMF). TMF raises money to fight neurological diseases like MS and Alzheimer's. The What's Bruin Show is happy to raise funds for this worthy charitable endeavor!Enjoy the What's Bruin Show Network!Multiple shows to entertain you on one feed:Support WBS at Patreon.com/WhatsBruinShow for just $2/month and get exclusive content and access to our SLACK channel.Twitter/X: @whatsbruinshow        Instagram: @whatsbruinshowCall the What's Bruin Network Hotline at 805-399-4WBS (Suck it Reign of Troy)We are also on YouTube HEREGet Your WBSN MERCH - Go to our MyLocker Site by Clicking HEREWhat's Bruin Show- A conversation about all things Bruin over drinks with Bruin Report Online's @mikeregaladoLA, @wbjake68 and friends!Subscribe to the What's Bruin Show at whatsbruin.substack.comEmail us at: whatsbruinshow@gmail.comTweet us at: @whatsbruinshowWest Coast Bias - LA Sports (mostly Lakers, Dodgers and NFL) with Jamaal and JakeSubscribe to West Coast Bias at wbwestcoastbias.substack.comEmail us at: WB.westcoastbias@gmail.comTweet us at: @WBwestcoastbiasThe BEAR Minimum - Jake and his Daughter Megan talk about student life and Cal Sports during her first year attending UC Berkeley.Subscribe to The BEAR Minimum at thebearminimum.substack.comEmail us at: wb.bearminimum@gmail.comTweet us at: @WB_BearMinimumPlease rate and review us on whatever platform you listen on.

What's up and welcome back to the Something's Bruin Podcast! On today's episode Sully and Mel discuss the chaos that was Bruins/Montreal on Saturday night. Zadorov's fight, Jeannot dropping Xhekaj and the significance of the win. The boys also discuss the Charlie McAvoy injury, Arvidsson injury, and Mittelstadt injury. The Bruins also made some roster moves including placing Harris, Mittelstadt and Arvidsson on IR while calling up Riley Tufte and Matej Blumel. We'd be remise if we didn't discuss Beecher on waivers. Is it the end of Beech SZN? As always, we dive into Mel's mailbag and dove into the twitter DMs!

Summary The conversation delves into the implications of recent legal decisions on gun rights, particularly focusing on the Bruin decision and its potential impact on ongoing cases. Mark Walters discusses the challenges faced in the judicial system, including the difficulty of getting cases to the Supreme Court and the influence of lower court judges appointed by previous administrations. Takeaways The Bruin decision has significant implications for gun rights. Winning cases in court is a challenging process. Less than 1% of filed cases reach the Supreme Court. Judicial stalling tactics are common in legal battles. Financial burdens are a strategy to deter legal action. Lower court judges may not uphold constitutional principles. The political landscape influences judicial decisions. The fight for gun rights is ongoing and complex. Legal strategies are essential for success in court. Understanding the judicial system is crucial for advocacy. Keywords gun rights, legal decisions, Supreme Court, judicial challenges, constitutional law  

Summary The conversation delves into the implications of recent legal decisions on gun rights, particularly focusing on the Bruin decision and its potential impact on ongoing cases. Mark Walters discusses the challenges faced in the judicial system, including the difficulty of getting cases to the Supreme Court and the influence of lower court judges appointed by previous administrations. Takeaways The Bruin decision has significant implications for gun rights. Winning cases in court is a challenging process. Less than 1% of filed cases reach the Supreme Court. Judicial stalling tactics are common in legal battles. Financial burdens are a strategy to deter legal action. Lower court judges may not uphold constitutional principles. The political landscape influences judicial decisions. The fight for gun rights is ongoing and complex. Legal strategies are essential for success in court. Understanding the judicial system is crucial for advocacy. Keywords gun rights, legal decisions, Supreme Court, judicial challenges, constitutional law  

Summary The conversation delves into the implications of recent legal decisions on gun rights, particularly focusing on the Bruin decision and its potential impact on ongoing cases. Mark Walters discusses the challenges faced in the judicial system, including the difficulty of getting cases to the Supreme Court and the influence of lower court judges appointed by previous administrations. Takeaways The Bruin decision has significant implications for gun rights. Winning cases in court is a challenging process. Less than 1% of filed cases reach the Supreme Court. Judicial stalling tactics are common in legal battles. Financial burdens are a strategy to deter legal action. Lower court judges may not uphold constitutional principles. The political landscape influences judicial decisions. The fight for gun rights is ongoing and complex. Legal strategies are essential for success in court. Understanding the judicial system is crucial for advocacy. Keywords gun rights, legal decisions, Supreme Court, judicial challenges, constitutional law  

Contrary to what everyone thought at the beginning of the year, the Bruins look legit and they showed it with a seven game winning streak. Nikita Zadorov is becoming a fan favorite and the perfect Bruin after last night's win over Toronto. Then, Bridgette Proulx of The Skate Pod joins the show to further the conversation and looks towards more rotation between Jeremy Swayman and Joonas Korpisalo as a factor in the B's success. And, its time for fans to root for Chaim Bloom in his new role with the Cardinals since his he had a bad hand dealt during his time with the Red Sox.

It almost became fight night at TD Garden, but things are looking more than up for the Bruins after their seventh straight win over the Maple Leafs. The physicality with Toronto last night showed why when you think about old school type Bruins, Nikita Zadorov fits the narrative.

Bruin's analyst Andrew Raycroft on Morgan Geekie's growth into an elite scorer

The boys take their quick shifts through the hockey news covering all the action. Stankoven drops the gloves. McDavid is putting the team on his back. Pasta got his 400th. The Ducks and Bruins are shocking everyone. Global Series is about to start. The Sharks vibes are back. And the Kings and Rags suck on the road. The Professors are back with Dr Locks to give you your weekend bets. Dan goes conspiracy theory crazy again. And what's the connection nearly stumped Chris. NEW EPISODES EVERY TUESDAY & THURSDAY! Watch full episodes, shorts, and clips right here on YouTube. Listen to the podcast on Spotify or anywhere you get your pods. Subscribe & follow Empty Netters everywhere: YouTube: / @emptynetters Instagram: @EmptyNetters TikTok: @EmptyNetters X: @EmptyNetters PRESENTED by BetMGM. Download the BETMGM app and use code “NETTERS” and enjoy up to $1500 in bonus bets if you lose your first wager! Thanks to our Sponsors! BetMGM: Use bonus code NETTERS when signing up to receive up to $1500 in bonus bets if your first bet loses. Gambling problem? Call 1-800-GAMBLER (Available in the US) 877-8-HOPENY or text HOPENY (467369) (NY) 1-800-327-5050 (MA), 1-800-NEXT-STEP (AZ), 1-800-BETS-OFF (IA), 1-800-981-0023 (PR) 21+ only. Please Gamble Responsibly. See BetMGM.com for Terms. First Bet Offer for new customers only. Subject to eligibility requirements. Bonus bets are non-withdrawable. In partnership with Kansas Crossing Casino and Hotel. This promotional offer is not available in New York, Nevada, Ontario, or Puerto Rico. Learn more about your ad choices. Visit megaphone.fm/adchoices

Jake is running for charity! If you would like to support his effort, donate HERE: https://fundraisers.hakuapp.com/wbjakeJake is running in the Rose Bowl Half-Marathon in January 2026 and would love to raise money for the McCourt Foundation (TMF). TMF raises money to fight neurological diseases like MS and Alzheimer's. The What's Bruin Show is happy to raise funds for this worthy charitable endeavor!Enjoy the What's Bruin Show Network!Multiple shows to entertain you on one feed:Support WBS at Patreon.com/WhatsBruinShow for just $2/month and get exclusive content and access to our SLACK channel.Twitter/X: @whatsbruinshow        Instagram: @whatsbruinshowCall the What's Bruin Network Hotline at 805-399-4WBS (Suck it Reign of Troy)We are also on YouTube HEREGet Your WBSN MERCH - Go to our MyLocker Site by Clicking HEREWhat's Bruin Show- A conversation about all things Bruin over drinks with Bruin Report Online's @mikeregaladoLA, @wbjake68 and friends!Subscribe to the What's Bruin Show at whatsbruin.substack.comEmail us at: whatsbruinshow@gmail.comTweet us at: @whatsbruinshowWest Coast Bias - LA Sports (mostly Lakers, Dodgers and NFL) with Jamaal and JakeSubscribe to West Coast Bias at wbwestcoastbias.substack.comEmail us at: WB.westcoastbias@gmail.comTweet us at: @WBwestcoastbiasThe BEAR Minimum - Jake and his Daughter Megan talk about student life and Cal Sports during her first year attending UC Berkeley.Subscribe to The BEAR Minimum at thebearminimum.substack.comEmail us at: wb.bearminimum@gmail.comTweet us at: @WB_BearMinimumPlease rate and review us on whatever platform you listen on.

Proudly sponsored by PyMC Labs, the Bayesian Consultancy. Book a call, or get in touch!Intro to Bayes Course (first 2 lessons free)Advanced Regression Course (first 2 lessons free)Our theme music is « Good Bayesian », by Baba Brinkman (feat MC Lars and Mega Ran). Check out his awesome work!Visit our Patreon page to unlock exclusive Bayesian swag ;)Thank you to my Patrons for making this episode possible!Yusuke Saito, Avi Bryant, Giuliano Cruz, James Wade, Tradd Salvo, William Benton, James Ahloy, Robin Taylor, Chad Scherrer, Zwelithini Tunyiswa, Bertrand Wilden, James Thompson, Stephen Oates, Gian Luca Di Tanna, Jack Wells, Matthew Maldonado, Ian Costley, Ally Salim, Larry Gill, Ian Moran, Paul Oreto, Colin Caprani, Colin Carroll, Nathaniel Burbank, Michael Osthege, Rémi Louf, Clive Edelsten, Henri Wallen, Hugo Botha, Vinh Nguyen, Marcin Elantkowski, Adam C. Smith, Will Kurt, Andrew Moskowitz, Hector Munoz, Marco Gorelli, Simon Kessell, Bradley Rode, Patrick Kelley, Rick Anderson, Casper de Bruin, Michael Hankin, Cameron Smith, Tomáš Frýda, Ryan Wesslen, Andreas Netti, Riley King, Yoshiyuki Hamajima, Sven De Maeyer, Michael DeCrescenzo, Fergal M, Mason Yahr, Naoya Kanai, Aubrey Clayton, Omri Har Shemesh, Scott Anthony Robson, Robert Yolken, Or Duek, Pavel Dusek, Paul Cox, Andreas Kröpelin, Raphaël R, Nicolas Rode, Gabriel Stechschulte, Arkady, Kurt TeKolste, Marcus Nölke, Maggi Mackintosh, Grant Pezzolesi, Joshua Meehl, Javier Sabio, Kristian Higgins, Matt Rosinski, Luis Fonseca, Dante Gates, Matt Niccolls, Maksim Kuznecov, Michael Thomas, Luke Gorrie, Cory Kiser, Julio, Edvin Saveljev, Frederick Ayala, Jeffrey Powell, Gal Kampel, Adan Romero, Will Geary, Blake Walters, Jonathan Morgan, Francesco Madrisotti, Ivy Huang, Gary Clarke, Robert Flannery, Rasmus Hindström, Stefan, Corey Abshire, Mike Loncaric, David McCormick, Ronald Legere, Sergio Dolia, Michael Cao, Yiğit Aşık, Suyog Chandramouli and Guillaume Berthon.Takeaways:AI is reshaping the workplace, but we're still in early stages.Networking is crucial for job applications in top firms.AI tools can augment work but are not replacements for skilled labor.Understanding the tech landscape requires continuous learning.Timing and cultural readiness are key for tech innovations.Expertise can be gained without formal education.Bayesian statistics is a valuable skill for tech professionals.The importance of personal branding in the job market. You just need to know 1% more than the person you're talking to.Sharing knowledge can elevate your status within a company.Embracing chaos in tech can create new opportunities.Investing in people leads...

Purdidn't.The Ohio State Buckeyes dispatched the Purdue Boilermakers with one starting wideout and one starting offensive tackle tied behind their backs, winning 34-10 on the road in West Lafayette, Indiana. Ohio State luckily avoided some of the nasty weather we saw in other games around the Big Ten on Saturday, but it wasn't one of the prettier games we've seen in the Ryan Day era. Then again, that can happen at Purdue.  We looked back at the Buckeyes' road win, discussed the key players, moments, and plays, and checked back on our picks to click and our final score predictions. After dissecting Ohio State's win over the Boilermakers, we took a quick spin around the rest of the B1G to see how other teams fared. Indiana looked to be in trouble against Penn State on the road, but the Nittany Lions stayed true to their nature and found a way to lose a close game against a top 10 team. We saw a few familiar things from Jim Knowles' defense on the decisive drive. Elsewhere, Nebraska's new quarterback had himself a nice game on the road as the Huskers beat UCLA out west. Oregon struggled in Iowa, but the Ducks pulled out a late win, with an untimely fumble by the Hawkeyes helping the visitors avoid a Kinnick Stadium upset. Rutgers got a vital win in a bid for bowl eligibility but the Scarlet Knights will still have a tough road to get to six wins. And, what do you know? Wisconsin won in conference play.  We also looked ahead to the matchups coming up this weekend. The Badgers will probably not win two in a row when they visit Bloomington. Probably. Meanwhile, Iowa will have a tough time bouncing back when they visit USC. There are some fun matchups coming up in Week 12. Finally, we previewed Ohio State's home game against UCLA. The Bruins' quarterback has played a night game at Ohio Stadium within the past year, and this trip to Columbus doesn't seem likely to yield a much better result. A raucous Horseshoe crowd, the nation's most efficient quarterback, and a bad Bruin defense don't seem to make for a good combination. We break down the matchup and provide our picks to click on Saturday on both sides of the ball and make our score predictions.  We would love to hear from you, so please reach out with your feedback and questions below in the comments section or send us an email at silverbulletspod@gmail.com. Any questions directed toward us will be answered on our next show.Be sure to subscribe, rate, review, share, and follow the show over on Twitter at @SilvrBulletsPod.As always, thanks for listening! 0:20 - An easy but boring day in West Lafayette.  26:05 - A look around the B1G. Penn State ain't gonna not Penn State, but maybe Saturday things will get better for the Nittany Lions.  47:03 - The Buckeyes host UCLA in a rare November night game. We discuss 

Jake is running for charity! If you would like to support his effort, donate HERE: https://fundraisers.hakuapp.com/wbjakeJake is running in the Rose Bowl Half-Marathon in January 2026 and would love to raise money for the McCourt Foundation (TMF). TMF raises money to fight neurological diseases like MS and Alzheimer's. The What's Bruin Show is happy to raise funds for this worthy charitable endeavor!Enjoy the What's Bruin Show Network!Multiple shows to entertain you on one feed:Support WBS at Patreon.com/WhatsBruinShow for just $2/month and get exclusive content and access to our SLACK channel.Twitter/X: @whatsbruinshow        Instagram: @whatsbruinshowCall the What's Bruin Network Hotline at 805-399-4WBS (Suck it Reign of Troy)We are also on YouTube HEREGet Your WBSN MERCH - Go to our MyLocker Site by Clicking HEREWhat's Bruin Show- A conversation about all things Bruin over drinks with Bruin Report Online's @mikeregaladoLA, @wbjake68 and friends!Subscribe to the What's Bruin Show at whatsbruin.substack.comEmail us at: whatsbruinshow@gmail.comTweet us at: @whatsbruinshowWest Coast Bias - LA Sports (mostly Lakers, Dodgers and NFL) with Jamaal and JakeSubscribe to West Coast Bias at wbwestcoastbias.substack.comEmail us at: WB.westcoastbias@gmail.comTweet us at: @WBwestcoastbiasThe BEAR Minimum - Jake and his Daughter Megan talk about student life and Cal Sports during her first year attending UC Berkeley.Subscribe to The BEAR Minimum at thebearminimum.substack.comEmail us at: wb.bearminimum@gmail.comTweet us at: @WB_BearMinimumPlease rate and review us on whatever platform you listen on.

Jake is running for charity! If you would like to support his effort, donate HERE: https://fundraisers.hakuapp.com/wbjakeJake is running in the Rose Bowl Half-Marathon in January 2026 and would love to raise money for the McCourt Foundation (TMF). TMF raises money to fight neurological diseases like MS and Alzheimer's. The What's Bruin Show is happy to raise funds for this worthy charitable endeavor!Enjoy the What's Bruin Show Network!Multiple shows to entertain you on one feed:Support WBS at Patreon.com/WhatsBruinShow for just $2/month and get exclusive content and access to our SLACK channel.Twitter/X: @whatsbruinshow        Instagram: @whatsbruinshowCall the What's Bruin Network Hotline at 805-399-4WBS (Suck it Reign of Troy)We are also on YouTube HEREGet Your WBSN MERCH - Go to our MyLocker Site by Clicking HEREWhat's Bruin Show- A conversation about all things Bruin over drinks with Bruin Report Online's @mikeregaladoLA, @wbjake68 and friends!Subscribe to the What's Bruin Show at whatsbruin.substack.comEmail us at: whatsbruinshow@gmail.comTweet us at: @whatsbruinshowWest Coast Bias - LA Sports (mostly Lakers, Dodgers and NFL) with Jamaal and JakeSubscribe to West Coast Bias at wbwestcoastbias.substack.comEmail us at: WB.westcoastbias@gmail.comTweet us at: @WBwestcoastbiasThe BEAR Minimum - Jake and his Daughter Megan talk about student life and Cal Sports during her first year attending UC Berkeley.Subscribe to The BEAR Minimum at thebearminimum.substack.comEmail us at: wb.bearminimum@gmail.comTweet us at: @WB_BearMinimumPlease rate and review us on whatever platform you listen on.

Thanks to Johnnie-O for the GREAT UCLA apparel!!! ... Go to Johnnie-O.com to get yours, or go directyly to the UCLA Stuff HERE: https://www.johnnie-o.com/collections/university-of-california-los-angeles?gender=men&filter-gender=MenJake is running for charity! If you would like to support his effort, donate HERE: https://fundraisers.hakuapp.com/wbjakeJake is running in the Rose Bowl Half-Marathon in January 2026 and would love to raise money for the McCourt Foundation (TMF). TMF raises money to fight neurological diseases like MS and Alzheimer's. The What's Bruin Show is happy to raise funds for this worthy charitable endeavor!Enjoy the What's Bruin Show Network!Multiple shows to entertain you on one feed:Support WBS at Patreon.com/WhatsBruinShow for just $2/month and get exclusive content and access to our SLACK channel.Twitter/X: @whatsbruinshow        Instagram: @whatsbruinshowCall the What's Bruin Network Hotline at 805-399-4WBS (Suck it Reign of Troy)We are also on YouTube HEREGet Your WBSN MERCH - Go to our MyLocker Site by Clicking HEREWhat's Bruin Show- A conversation about all things Bruin over drinks with Bruin Report Online's @mikeregaladoLA, @wbjake68 and friends!Subscribe to the What's Bruin Show at whatsbruin.substack.comEmail us at: whatsbruinshow@gmail.comTweet us at: @whatsbruinshowWest Coast Bias - LA Sports (mostly Lakers, Dodgers and NFL) with Jamaal and JakeSubscribe to West Coast Bias at wbwestcoastbias.substack.comEmail us at: WB.westcoastbias@gmail.comTweet us at: @WBwestcoastbiasThe BEAR Minimum - Jake and his Daughter Megan talk about student life and Cal Sports during her first year attending UC Berkeley.Subscribe to The BEAR Minimum at thebearminimum.substack.comEmail us at: wb.bearminimum@gmail.comTweet us at: @WB_BearMinimumPlease rate and review us on whatever platform you listen on.

In the Week 6 Sunday Hurry-Up presented by Dad Water, Richard and Alex break down a college football weekend that turned out to have a bit of everything: * UCLA 42, Penn State 37* Washington 24, Maryland 20* Michigan 24, Wisconsin 10* Nebraska 38, Michigan State 27* Illinois 43, Purdue 27* Ohio State 42, Minnesota 3* Alabama 30, Vanderbilt 14* Florida 29, Texas 21* Georgia 35, Kentucky 14* Texas A&M 31, Mississippi State 9* Miami 28, Florida State 22* Clemson 38, North Carolina 10* Virginia 30, Louisville 27* Pitt 48, Boston College 7* Duke 45, California 21* Cincinnati 38, Iowa State 30* BYU 38, West Virginia 24* Texas Tech 35, Houston 11 * TCU 35, Colorado 21* Baylor 35, Kansas State 34* Arizona 41, Oklahoma State 13* Navy 34, Air Force 31* Army 31, UAB 13* USF 54, Charlotte 26* Temple 27, UTSA 21* Notre Dame 28, Boise State 7* San Diego State 45, Colorado State 24* UNLV 31, Wyoming 17* Arkansas State 31, Texas State 30* Old Dominion 47, Coastal Carolina 7* App State 27, Oregon State 23* WKU 27, Delaware 24* New Mexico State 37, Sam Houston 10* Buffalo 31, Eastern Michigan 30 * Akron 28, Central Michigan 22* Western Carolina 23, Wofford 21Producer: Anthony Vito. Want much more? Become a paid subscriberWe're planning our usual two-subscriber-show load for you this week.Thanks to our partners and subscribers* 20% off Dad Water: https://drinkdadwater.com/discount/SZD* Visit Homefield at https://www.homefieldapparel.com/* Enter to win airfare and lodging for a trip to New York City on conference championship weekend at https://www.nokiantyres.com/SZD This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.splitzoneduo.com/subscribe