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Featuring perspectives from Dr Rachel N Grisham, including the following topics: Case: A woman in her early 40s with recurrent low-grade serous ovarian cancer (LGSOC) and prior treatment with a MEK inhibitor receives avutometinib/defactinib on the RAMP 301 trial (0:00) Case: A woman in her early 70s with recurrent KRAS-mutated LGSOC receives avutometinib/defactinib and develops muscle weakness (10:03) Case: A woman in her late 70s with KRAS-mutated recurrent LGSOC develops congestive heart failure on trametinib and then receives avutometinib/defactinib (16:15) Case: A woman in her mid 60s with recurrent BRAF V600E LGSOC has concerns about side effects and receives single-agent dabrafenib (19:49) CME information and select publications
Featuring perspectives from Dr Rachel N Grisham, including the following topics: Mechanism, clinical evidence and practical use of avutometinib with defactinib for recurrent low-grade serous ovarian cancer (LGSOC) (0:00) A Phase III trial of letrozole alone as front-line treatment for LGSOC (11:11) Current and future role of avutometinib with defactinib for LGSOC (19:23) A Phase II/III trial of trametinib for recurrent LGSOC: Biomarker analyses and clinical implications (21:37) CME information and select publications
Featuring perspectives from Dr Floor J Backes, Dr Matthew A Powell and Dr Ritu Salani, moderated by Dr Salani, including the following topics: Case: A woman in her late 60s with recurrence of metastatic estrogen receptor-positive endometrial cancer enrolls in a trial of CDK4/6 inhibition with an aromatase inhibitor 1 year into maintenance dostarlimab after carboplatin/paclitaxel/dostarlimab and has no evidence of disease 3 years later (0:00) Adding a PARP inhibitor to immunotherapy and chemotherapy: The RUBY Part 2 and DUO-E trials (10:03) CME information and select publications
Featuring perspectives from Prof John Seymour and cases from Dr Daniel Ermann, Dr Shazia Nakhoda and Dr Mahesh Swaminathan, including the following topics: Case: A woman in her mid 50s with multiple sclerosis, hypertension, IGHV-unmutated chronic lymphocytic leukemia (CLL) with an SF3B1 mutation and autoimmune hemolytic anemia receives acalabrutinib/venetoclax/obinutuzumab (0:00) Case: A man in his late 60s with bulky CLL diagnosed abroad receives zanubrutinib monotherapy (12:48) Case: A man in his late 40s with IGHV-mutated, del(13q) CLL with worsening symptoms and diffuse adenopathy after 1 year of observation receives venetoclax/obinutuzumab and attains a complete response (21:29) CME information and select publications
Featuring perspectives from Prof John Seymour, including the following topics: Safety of fixed-duration acalabrutinib/venetoclax for chronic lymphocytic leukemia (CLL) (0:00) Venetoclax re-treatment and ongoing trials with acalabrutinib/venetoclax for CLL (6:21) First-line treatment with sonrotoclax and zanubrutinib for CLL (13:10) CME information and select publications
Featuring perspectives from Dr Karim Fizazi, Dr Daniel George and Dr Elisabeth I Heath, moderated by Dr Heath, including the following topics: Tolerability of capivasertib and management of associated side effects — Question from Neeraj Agarwal, MD, FASCO (0:00) Case: A man in his early 70s with Type 2 diabetes presents with metastatic hormone-sensitive prostate cancer with widespread bone metastases and PTEN deficiency on next-generation sequencing and receives relugolix/darolutamide — Rana R McKay, MD, FASCO (8:39) CME information and select publications
Featuring perspectives from Dr Terence Friedlander, Dr Matthew Galsky, Dr Shilpa Gupta and Prof Andrea Necchi, moderated by Dr Friedlander, including the following topics: Case: A patient with T4 disease, pelvic wall involvement and a positive pelvic node treated as metastatic disease with enfortumab vedotin and pembrolizumab attains a complete response on imaging after 6 cycles (0:00) Case: A man with muscle-invasive bladder cancer who receives neoadjuvant chemotherapy with durvalumab receives positive circulating tumor DNA results before cystectomy and negative results after surgery (7:41) CME information and select publications
Featuring perspectives from Dr Terence Friedlander, Dr Matthew Galsky, Dr Shilpa Gupta and Prof Andrea Necchi, moderated by Dr Friedlander, including the following topics: Case: A man in his early 80s with non-muscle-invasive bladder cancer (NMIBC) monitored by repeat TURBTs develops localized muscle-invasive bladder cancer and enrolls in a clinical trial of neoadjuvant enfortumab vedotin with pembrolizumab (0:00) Case: A man in his late 70s with newly diagnosed NMIBC with carcinoma in situ (CIS) receives BCG induction and experiences relapse of CIS during BCG maintenance (9:24) CME information and select publications
Featuring perspectives from Dr Karim Fizazi, Dr Daniel George and Dr Elisabeth I Heath, moderated by Dr Heath, including the following topics: Treatment approach for AKT-mutated prostate cancer — Question from Neeraj Agarwal, MD, FASCO (0:00) Case: A man in his late 60s with de novo metastatic hormone-sensitive prostate cancer with widespread skeletal metastases and PTEN loss on next-generation sequencing receives relugolix/darolutamide with chemotherapy and experiences PSA decline that plateaus at approximately 1 ng/mL — Rana R McKay, MD, FASCO (10:29) CME information and select publications
Featuring perspectives from Dr Karim Fizazi, Dr Daniel George and Dr Elisabeth I Heath, moderated by Dr Heath, including the following topics: Role of PTEN deficiency in tumorigenesis of prostate cancer and optimal approach to PTEN assessment — Question from Neeraj Agarwal, MD, FASCO (0:00) Case: A man in his late 60s with a history of nonmetastatic hormone-sensitive prostate cancer (HSPC) that progressed to metastatic HSPC with PTEN loss by next-generation sequencing of primary archival tissue from 2017 receives abiraterone for 2 years — Rana R McKay, MD, FASCO (8:26) CME information and select publications
Send us Fan MailThis month on the productivity podcast Ben Collier, co-founder at Ocasta discusses how streamlining store communications is helping drive actionable tasks, frontline micro-learning, and better sales conversions, and looks ahead to when AI will automatically guide managers through effective team coaching.Key takeaways:From Consumer Apps to Frontline Operations: How a serendipitous project shifted Ocasta from building consumer apps for major brands into creating user-friendly, bespoke operations platforms for retail enterprises.Removing Operational Guesswork: Why turning disguised head-office communications into clear, actionable tasks with real-time visibility eliminates confusion on the shop floor.Micro-Learning in the Flow of Work: How extending traditional knowledge bases into bite-sized, AI-generated training allows store teams to access and complete critical standard operating procedures in just minutes.The AI-Powered Coach: A look ahead at Ocasta's upcoming AI coaching assistant, designed to analyse real in-store observation data and provide managers with tailored action plans and prompts—removing the guesswork from human judgment.Ocasta Webinar: Watch the Webinar Ben mentions in the PodEvent Alert: Catch up with Ben and the Ocasta team to get an early look at their new AI coaching assistant at the upcoming Productivity Forum.
Featuring perspectives from Dr Terence Friedlander, Dr Matthew Galsky, Dr Shilpa Gupta and Prof Andrea Necchi, moderated by Dr Friedlander, including the following topics: Case: A woman in her late 60s with T3N0 upper tract urothelial carcinoma that was resected has no evidence of disease on imaging, receives negative circulating tumor DNA results and elects observation instead of adjuvant treatment (0:00) Case: A man in his late 70s with PD-L1-negative high-grade muscle-invasive bladder cancer who is ineligible for cisplatin because of poor renal function undergoes cystectomy (10:12) CME information and select publications
Featuring perspectives from Dr Terence Friedlander, Dr Matthew Galsky, Dr Shilpa Gupta and Prof Andrea Necchi, moderated by Dr Friedlander, including the following topics: Case: A healthy man in his early 70s who received several different lines of therapy for non-muscle-invasive bladder cancer (NMIBC), wants to avoid radical cystectomy and does not want pembrolizumab (0:00) Case: A man in his late 70s with newly diagnosed NMIBC with carcinoma in situ (11:20) CME information and select publications
In this episode of Trending in Education, host Mike Palmer sits down with Mike Peng, Founder and Managing Partner of Weatherstone Capital Partners, to explore the evolving intersection of education, technology, and capital markets. After missing a meeting at ASU+GSV in San Diego, Mike and Mike reconnect to unpack what it takes to scale educational ventures past the startup phase and navigate the broader macroeconomic shift from venture capital to private equity in EdTech. Drawing from his unique career journey—from engineering at UT Austin and strategy consulting at McKinsey to leading rapid growth at Block Renovation and earning an MBA at Stanford—Peng shares why Weatherstone focuses on partnering with operators in the 1-to-10 scale stage ($1M to $10M EBITDA range). Together, they examine the real "moats" in the age of AI (data ownership and customer relationships over UI), why corporate L&D and continuing certification are outperforming traditional K-12/Higher Ed models for private equity, and how simulation tools and micro-learning are reshaping workforce upskilling. Peng also offers vital advice for founders assessing whether they are the "limiting factor" in their company's growth and how to navigate tight capital markets. KEY INSIGHTS: 0-to-1 vs. 1-to-10 Leadership: Building a product from scratch requires a scrappy, zero-to-one mindset, whereas scaling from 1 to 10 demands processes, enterprise workflows, and founders willing to look in the mirror to ensure they aren't becoming their company's limiting factor. The Capital Shift from VC to PE: With EdTech valuations down ~60% from 2021 peaks and market maturity kicking in, 2024 marked a pivot where private equity outpaced venture capital in EdTech funding—shifting the focus from hyper-growth to unit economics, profitability, and sustainable scale. Redefining AI Moats: User interface (UI) and simple API connections to large language models are no longer defensible differentiators. True AI moats reside in owning proprietary data, maintaining deep customer trust, and controlling end-to-end customer relationships. Corporate L&D and Reskilling Demand: While K-12 and Higher Ed present longer sales cycles and risk aversion, Corporate L&D—particularly recurring certification, micro-training in daily workflows, and AI simulation (e.g., bedside manner nursing)—presents massive opportunity as 85% of employers seek to reskill their workforce by 2030. Founder Discipline in Tight Markets: Bootstrapping and pivoting quickly are more viable than ever thanks to AI MVP acceleration. Founders must plan capital runway at least a year in advance and regularly "come up for air" so market evolution doesn't leave their business behind. TIMESTAMPS: 00:00 – Introduction & Connecting Post-ASU+GSV 01:00 – Mike Peng's Journey: UT Austin, McKinsey, Block Renovation, & Stanford MBA 02:30 – Inside Weatherstone Capital Partners: Long-Term Platform Investing 03:30 – 0-to-1 vs. 1-to-10: Passing the Founder "Mirror Test" 05:30 – Takeaways from ASU+GSV: AI Undercurrents & Modern Moats 07:30 – Career Readiness, CTE, & The 1,400-Tool EdTech Stack 09:30 – Data is the New Oil, AI is the New Electricity 11:30 – Managing Hallucination Risk & Trust in Classroom Tech 13:30 – Segmenting EdTech: Why Capital is Moving from VC to PE 18:00 – The Future of Work: LXP, Micro-Learning, & AI Simulations 23:30 – Personal AI Tutors, Spatial Hardware, & Final Advice for Founders 26:00 – Wrap Up & How to Connect with Weatherstone Subscribe to Trending in Ed wherever you get your podcasts to stay ahead of the curve in learning, media, and the future of work.
Chris Craig, FixedOps Content Developer at RockEd, joins Kaylee Felio to dive into the launch of Rocket's powerful new training curriculum for parts departments. They get gritty on why parts managers and associates have been overlooked—until now.From microlearning and gamification to actionable reporting and industry certification, Chris Craig breaks down how RockEd is changing the game for parts teams across the country. If you're ready to fix the foundation, turn inventory faster, and give your team smarter tools, this episode brings the insights, energy, and optimism you need.--------------------------------------------TakeawaysMicrolearning Empowers Busy TeamsGamification Drives EngagementIndustry-Recognized CertificationChapters00:00 Military training and education04:21 Balancing Army duties and work06:40 Rocket's microlearning solution for dealerships10:40 Understanding the parts manager role14:25 Accessing Rocket Preview Mode17:17 Rocketified learning platform overview20:18 Checking out the RockEd appKaylee FelioLinkedIn: https://www.linkedin.com/in/kayleefelioWebsite: https://www.partsedge.comChris CraigLinkedIn: https://www.linkedin.com/in/chris-topher-craigRockED Websitehttps://www.rocked.us/technician-skills
Featuring perspectives from Dr Joshua K Sabari, including the following topics: Heymach JV et al. Zongertinib in previously treated HER2-mutant non-small cell lung cancer. N Engl J Med 2025;392(23):2321-33. (0:00) Popat S et al. Zongertinib as first-line treatment in patients with advanced HER2-mutant NSCLC: Beamion LUNG-1. ESMO 2025;Abstract LBA74. (5:25) Le X et al. Sevabertinib in advanced HER2-mutant non-small cell lung cancer. N Engl J Med 2025;393(18):1819-32. (12:37) CME information and select publications
Featuring perspectives from Dr Joshua K Sabari, including the following topics: Jänne PA et al. Final analysis results and patient-reported outcomes from DESTINY-Lung02 — A dose-blinded, randomized, phase 2 study of trastuzumab deruxtecan in patients with HER2-mutant metastatic NSCLC. J Thorac Oncol 2025;20(12):1814-28. (0:00) Heymach JV et al. Circulating tumor DNA (ctDNA) analysis following zongertinib treatment (tx) in patients (pts) with human epidermal growth factor receptor 2 (HER2)-mutant non-small cell lung cancer (NSCLC): Phase Ia/Ib Beamion LUNG-1 study. ESMO 2025;Abstract 2020P. (8:30) Schram AM et al. Beamion PANTUMOR-1: Rationale and design of a phase II trial of zongertinib in HER2-overexpressed/amplified or HER2-mutant solid tumors. Future Oncol 2026;22(7):795-803. (12:53) Johnson ML et al. Beamion LUNG-2: A phase III randomized controlled trial of zongertinib (BI 1810631) versus standard of care in patients with locally advanced/metastatic non-squamous NSCLC harboring HER2 tyrosine kinase domain (TKD) mutations. ASCO 2024;Abstract TPS8654. (19:40) Le X et al. SOHO-02: Phase III trial of BAY 2927088 in patients with locally advanced or metastatic NSCLC with HER2-activating mutations. ASCO 2025;Abstract TPS8648. (21:41) Li BT et al. Open-label, randomized, multicenter, phase 3 study evaluating trastuzumab deruxtecan (T-DXd) as first-line treatment in patients with unresectable, locally advanced, or metastatic non-small cell lung cancer (NSCLC) harboring HER2 exon 19 or 20 mutations (DESTINY-Lung04). ASCO 2022;Abstract TPS9137. (22:59) Jänne PA et al. Trastuzumab deruxtecan for ERBB2-mutant metastatic NSCLC with or without brain metastases: A secondary analysis of randomized clinical trials. JAMA Netw Open 2025;8(11):e2543107. (24:37) CME information and select publications
Featuring perspectives from Dr Mazyar Shadman and cases from Dr Daniel Ermann, Dr Shazia Nakhoda and Dr Mahesh Swaminathan, including the following topics: Case: A man in his mid 40s with chronic lymphocytic leukemia (CLL) receives acalabrutinib/venetoclax as part of the MAJIC trial (0:00) Case: A man in his early 70s with TP53-mutated CLL expresses concern about side effects associated with zanubrutinib (8:22) Case: A man in his late 70s with Stage IIIB chronic kidney disease and CLL receives obinutuzumab (18:02) CME information and select publications
Featuring perspectives from Dr Mazyar Shadman, including the following topics: The CLL17 trial: Fixed-duration versus continuous targeted treatment for previously untreated chronic lymphocytic leukemia (CLL) (0:00) The AMPLIFY trial: Fixed-duration acalabrutinib combinations for untreated CLL (5:31) Zanubrutinib-based therapy for treatment-naïve CLL (12:32) CME information and select publications
What happens when AI makes creating learning content easier than ever? According to 7taps co-founder Ezra Charm, that's when the real work of learning and development begins. In this episode, Ezra joins the Powered by Learning team to discuss why the future of L&D is about more than creating content—it's about driving engagement, improving performance, and measuring impact.Show Notes:From the rise of the "LMS-less learner" to the role of AI in modern learning strategies, 7tap's Ezra Charm shares why learning professionals have an opportunity to become more valuable than ever. Here are some of Ezra's top takeaways.AI is shifting L&D's role from content creation to performance improvement. As authoring becomes easier, learning professionals can focus on driving behavior change and demonstrating business value. Organizations don't have a content problem—they have an engagement problem. Success depends on delivering learning when and where employees need it, not simply creating more courses. Learning should meet employees where they work. Today's "LMS-less learner" expects learning to be accessible on any device, in the flow of work, rather than requiring a trip back into the LMS. Microlearning works because it's grounded in learning science. By respecting cognitive load, spaced repetition, and mobile-first behaviors, organizations can improve retention and application. The future of L&D is measuring impact. Learning teams that can connect training to business outcomes will move from being viewed as cost centers to strategic business partners.Learn more about 7tapsRead more about d'Vinci's partnership with 7tapsAbout Ezra Charm:Ezra Charm is Co-Founder and COO of 7taps, where he's spent years building the brand and go-to-market engine for the microlearning platform. A marketing leader with deep startup experience, he's known for challenging conventional L&D thinking and pushing teams to focus on business outcomes over completion metrics.Powered by Learning earned Awards of Distinction in the Podcast/Audio and Business Podcast categories from The Communicator Awards and a Gold and Silver Davey Award. The podcast is also named to Feedspot's Top 40 L&D podcasts and Training Industry's Ultimate L&D Podcast Guide. Learn more about d'Vinci at www.dvinci.com. Follow us on LinkedInLike us on Facebook
Featuring perspectives from Dr Floor J Backes, Dr Matthew A Powell and Dr Ritu Salani, moderated by Dr Salani, including the following topics: Case: A woman in her late 60s presents with mismatch repair-deficient metastatic endometrial cancer(00:00) Perspectives on neoadjuvant immunotherapy for microsatellite instability-high endometrial cancer (06:25) CME information and select publications
Featuring perspectives from Dr Floor J Backes, Dr Matthew A Powell and Dr Ritu Salani, moderated by Dr Salani, including the following topics: Case: A woman in her late 70s with de novo metastatic mismatch repair-proficient metastatic endometrioid endometrial cancer (00:00) Molecular analyses in the assessment and management of endometrial cancer (07:33) CME information and select publications
Featuring an interview with Prof Bernd Kasper, including the following topics: Case: A woman in her early 30s develops a progressing desmoid tumor in her abdomen during pregnancy(0:00) Case: A woman in her late 30s with a painful small desmoid tumor in her rectus abdominus undergoes cryoablation (8:04) Case: A woman in her late teens with recurrent desmoid tumors in her right thigh undergoes multiple resections (13:58) Case: A woman in her mid 70s has a desmoid tumor causing erosion in her scapular region (17:19) CME information and select publications
Interview conducted with Prof Bernd Kasper on March 5, 2026, by Dr Neil Love, including the following topics: Current management of desmoid tumors: A review from the Desmoid Tumor Working Group (0:00) Long-term nirogacestat treatment in adult patients with desmoid tumors: Updated efficacy and safety from the Phase III DeFi trial (8:26) Phase IV trial of nirogacestat in adult premenopausal women with desmoid tumors (17:35) CME information and select publications here.
What does it take to deliver impactful learning in a global, highly regulated industry? Tim Greiner, Senior Director of USP Education at the U.S. Pharmacopeia, a global nonprofit that sets quality standards for medicines, food, and dietary supplements, shares how USP delivers education at scale to ensure those standards are applied effectively across industries and regions to improve quality and protect public health. Show Notes:Senior Education Director Tim Greiner explains how USP delivers training that improves quality and performance. Key takeaways from the conversation include:Impact over completion: In regulated environments, training success is measured by behavior change and improved quality practices—not just course completion. Design for diverse, global audiences: Effective programs balance modalities, regional preferences, and roles (regulators, manufacturers, students) without overcomplicating delivery. Blended learning drives stronger outcomes: Live and live-virtual experiences tend to have the highest impact, especially when paired with self-paced resources for reinforcement. Operational discipline matters at scale: Managing global training requires strong processes—centralized content, regular reviews, and alignment with evolving standards. Microlearning in the flow of work is the future: Delivering targeted learning at the exact moment of need can significantly increase retention, application, and overall impact. Powered by Learning earned Awards of Distinction in the Podcast/Audio and Business Podcast categories from The Communicator Awards and a Gold and Silver Davey Award. The podcast is also named to Feedspot's Top 40 L&D podcasts and Training Industry's Ultimate L&D Podcast Guide. Learn more about d'Vinci at www.dvinci.com. Follow us on LinkedInLike us on Facebook
Featuring proceedings from a live event on January 9, 2026, held adjunct to the 2026 ASCO Gastrointestinal Cancers Symposium and moderated by Dr Samuel J Klempner, including the following topics: Treatment approach for metastatic HER2-negative, claudin 18.2-positive, microsatellite instability-high gastroesophageal (GE) cancer (0:00) Duration of chemotherapy for patients with advanced GE cancers receiving nivolumab/chemotherapy (3:06) Younger patient with metastatic PD-L1-positive gastric cancer (5:29) CME information and select publications
Feedback, both recieving and giving are so important at work. We will go through a few points in this episodeFeedback is not just what you say, but when and how you say it.Intent without clarity creates confusion.Respect determines whether feedback is heard or resisted.Specific feedback is more useful than vague criticism.Trust makes honesty possible.You can email me at AgileMalayali@gmail.com and connect on LinkedIn https://www.linkedin.com/in/vinodn/ You can also join our Telegram Learning GroupAlso checkout my other Podcasts Other PodcastsPahayan Talks Malayalam PodcastVayanalokam Malayalam Book PodcastEnglish Podcast Penpositive OutclassYouTube ChannelsPahayan Talks Youtube ChannelAgile Malayali YouTube ChannelPenpositive YouTube Channel
Education is key to preventing damage to underground infrastructure and keeping workers and communities safe. In this episode, Common Ground Alliance's Erika Lee and Lisa O'Leary share how their Excavator Damage Prevention curriculum is using data-driven training to change behavior and reduce risk.Show Notes:CGA's Erika Lee and Lisa O'Leary discuss how their comprehensive training curriculum is tackling the root causes of damage through education, accessibility, and industry collaboration. Their key points include:Education is the first line of defense against excavation damage: Erika Lee emphasized that if workers don't understand risks and best practices, “we're really not setting them up for success.”Failure to contact 811 remains the leading cause of damage: The top root cause year over year is not calling 811 before digging—highlighting a major opportunity for behavior change.Up to 65% of damage incidents are preventable through behavior change: The majority of incidents are tied to excavator actions that can be improved through targeted training, according to Erika.Microlearning and accessibility are key to adoption: Lisa O'Leary shared that short, 5–7 minute modules and mobile-friendly access make it easier for workers in the field to engage with training.Collaboration and consensus drive better outcomes: Common Ground Alliance's consensus-based approach ensures diverse stakeholders align on best practices—strengthening both the curriculum and industry impact.Learn more about Common Ground Alliance's education program. Explore d'Vinci's work with Common Ground Alliance. Powered by Learning earned Awards of Distinction in the Podcast/Audio and Business Podcast categories from The Communicator Awards and a Gold and Silver Davey Award. The podcast is also named to Feedspot's Top 40 L&D podcasts and Training Industry's Ultimate L&D Podcast Guide. Learn more about d'Vinci at www.dvinci.com. Follow us on LinkedInLike us on Facebook
Starting is very common but finishing is not. We will go through a few points in this videoStarting is driven by excitement; finishing is driven by discipline.Many people collect beginnings but avoid endings.Half-finished work drains mental energy.Completion creates real value, not intention.Confidence grows when you consistently finish what you start.You can email me at AgileMalayali@gmail.com and connect on LinkedIn https://www.linkedin.com/in/vinodn/ You can also join our Telegram Learning GroupAlso checkout my other Podcasts Other PodcastsPahayan Talks Malayalam PodcastVayanalokam Malayalam Book PodcastEnglish Podcast Penpositive OutclassYouTube ChannelsPahayan Talks Youtube ChannelAgile Malayali YouTube ChannelPenpositive YouTube Channel
Dr Stacey A Cohen from Fred Hutchinson Cancer Center in Seattle, Washington, Dr Jenny Seligmann from the University of Leeds in the United Kingdom and Dr Christopher Lieu from the University of Colorado Cancer Center in Aurora review clinical findings from the 2026 ASCO Gastrointestinal Cancers Symposium relevant to the management of localized colorectal cancer. CME information and select publications here.
Featuring perspectives from Dr Stacey A Cohen, Dr Christopher Lieu and Dr Jenny Seligmann, moderated by Dr Lieu, including the following topics: Role of circulating tumor DNA (ctDNA) testing in the escalation of treatment for Stage II and deescalation for Stage III colon cancer (0:00) Impact of timing on the clinical relevance of ctDNA minimal residual disease test results in localized colorectal cancer (8:58) Approach to managing Stage III colon cancer with ctDNA-positive results after adjuvant treatment (13:35) CME information and select publications
Asking better questions is a key aspect of work. We will go through three points in this videoQuestions shape how we think about problems.Good questions reveal systems and relationships.Curiosity creates clarity.You can email me at AgileMalayali@gmail.com and connect on LinkedIn https://www.linkedin.com/in/vinodn/ You can also join our Telegram Learning GroupAlso checkout my other Podcasts Other PodcastsPahayan Talks Malayalam PodcastVayanalokam Malayalam Book PodcastEnglish Podcast Penpositive OutclassYouTube ChannelsPahayan Talks Youtube ChannelAgile Malayali YouTube ChannelPenpositive YouTube Channel
Featuring perspectives from Dr Jaffer A Ajani, Dr Samuel J Klempner, Dr Rutika Mehta and Dr John Strickler, moderated by Dr Klempner, including the following topics: Role of PD-L1 status, tumor histology and pulmonary disease in selection of immune checkpoint inhibition as up-front therapy (0:00) Impact of metastatic site and autoimmune disease on clinical decision-making in the use of immune checkpoint inhibition (5:56) Biomarker assessment approach and treatment selection (10:50) CME information and select publications
Dr Jaffer Ajani from The University of Texas MD Anderson Cancer Center in Houston, Dr Samuel Klempner from Massachusetts General Hospital in Boston, Dr Rutika Mehta from Weill Cornell Medicine/NewYork-Presbyterian Hospital in New York, New York, and Dr John Strickler from Duke University in Durham, North Carolina, review relevant data supporting immunotherapy for patients with gastroesophageal cancers and review recently presented clinical findings from the 2026 ASCO Gastrointestinal Cancers Symposium. CME information and select publications here.
Featuring perspectives from Dr Stacey A Cohen, Dr Christopher Lieu and Dr Jenny Seligmann, moderated by Dr Lieu, including the following topics: Adjuvant treatment planning for Stage II or III microsatellite instability-high colon cancer (0:00) Roles of circulating tumor DNA (ctDNA), POLE mutations and advanced age in adjuvant treatment planning (6:08) Role of ctDNA in adjuvant treatment planning for Stage III colon cancer (12:31) CME information and select publications
Featuring perspectives from Dr Paul G Richardson, including the following topics: EXCALIBER-RRMM: A Phase III trial of iberdomide, daratumumab and dexamethasone for relapsed/refractory multiple myeloma (0:00) Lonial S et al. EXCALIBER-RRMM: A phase III trial of iberdomide, daratumumab, and dexamethasone in relapsed/refractory multiple myeloma. Future Oncol 2025;21(14):1761-9. Abstract Phase III SUCCESSOR-1 and SUCCESSOR-2 studies evaluating mezigdomide-based regimens for relapsed/refractory multiple myeloma (8:24) Richardson PG et al. A phase III, two-stage, randomized study of mezigdomide, bortezomib, and dexamethasone (MeziVd) versus pomalidomide, bortezomib, and dexamethasone (PVd) in relapsed/refractory multiple myeloma (RRMM): SUCCESSOR-1. SOHO 2023;Abstract MM-372. Richardson PG et al. A phase 3, two-stage, randomized study of mezigdomide, carfilzomib, and dexamethasone (MeziKd) versus carfilzomib and dexamethasone (Kd) in relapsed/refractory multiple myeloma (RRMM): SUCCESSOR-2. ASCO 2023;Abstract TPS8070. EMN26: A Phase II study of maintenance therapy with iberdomide after autologous stem-cell transplantation for newly diagnosed multiple myeloma (13:34) van de Donk NWCJ et al. Iberdomide maintenance after autologous stem-cell transplantation in newly diagnosed multiple myeloma: An update from the phase 2 EMN26 trial. ASH 2025;Abstract 101. STOMP: A Phase I study of selinexor, mezigdomide and dexamethasone for patients with relapsed/refractory multiple myeloma who experienced relapse with or are ineligible for T-cell-redirecting therapy (24:53) Mo C et al. Selinexor, mezigdomide, and dexamethasone in patients with relapsed/refractory multiple myeloma who relapsed or are ineligible for T-cell–redirecting therapy: Stomp Phase 1 results. ASH 2025;Abstract 4010. CME information and select publications
Dr Paul G Richardson from the Dana-Farber Cancer Institute in Boston, Massachusetts, discusses how CELMoDs function, available data with these agents and their possible future role in the treatment of multiple myeloma.CME information and select publications here.
Featuring perspectives from Dr Haley Ellis, Prof Eric Van Cutsem and Dr Zev Wainberg, moderated by Dr Lionel A Kankeu Fonkoua, including the following topics: Gastroesophageal cancer (0:00) Recurrent colorectal cancer (5:43) Colorectal cancer with brain metastases (9:59) CME information and select publications
Featuring an interview with Dr Ravin Ratan, including the following topics: Case: A woman in her early 40s who develops intense nausea and vomiting and is diagnosed with a pelvic desmoid tumor elects surveillance and experiences spontaneous regression of the tumor (0:00) Case: A woman in her late 30s with a painful desmoid tumor in the right pelvic wall receives cryoablation because of concerns about ovarian function (6:49) Case: A woman in her early 40s with breast implants and multiple resections of breast desmoid tumors receives nirogacestat for 2 years with positive response but develops mucositis and Grade 1 asthenia and stops treatment (14:10) Case: A woman in her mid 30s with a history of gastric sleeve and endometriosis presents with a painful desmoid tumor in the left upper quadrant, receives nirogacestat with headaches and gastrointestinal symptoms that improve over time and experiences a decrease in tumor size (21:27) CME information and select publications
Most safety training is easy to forget – because it's designed to be delivered, not retained. In this episode, Mark Woodward, Director of Training and Safety Manager at Sellenriek Construction, shares how microlearning turns workplace training into a tool that actually changes behavior, builds consistency, and shows up in safety outcomes over time.
Featuring perspectives from Dr Jaffer A Ajani, Dr Samuel J Klempner, Dr Rutika Mehta and Dr John Strickler, moderated by Dr Klempner, including the following topics: Older patient with metastatic claudin 18.2-positive gastroesophageal (GE) cancer (0:00) Management of nausea and vomiting with zolbetuximab for GE cancer (9:37) Younger patient with metastatic claudin 18.2-positive, PD-L1-positive GE cancer (15:34) CME information and select publications
Featuring an interview with Dr Hanny Al-Samkari, including the following topics: Case: A man in his early 40s with chronic immune thrombocytopenia (ITP) receives romiplostim with rituximab — Bhavana (Tina) Bhatnagar, DO (0:00) Case: A woman in her early 80s with metastatic adenocarcinoma of the lung responds to carboplatin/pemetrexed/pembrolizumab but after 14 months of maintenance pembrolizumab presents with ITP — Susmitha Apuri, MD (6:48) Case: A man in his late 70s with a 30-year history of chronic ITP who received corticosteroids and rituximab now receives avatrombopag — Sunil Gandhi, MD (12:06) Case: A woman in her early 80s with multiple comorbidities and a long history of ITP presents with confusion and fluid retention due to exacerbated congestive heart failure and receives fostamatinib — Dr Bhatnagar (19:26) CME information and select publications
Dr Hanny Al-Samkari from Massachusetts General Hospital in Boston discusses recent developments from the ASH 2025 Annual Meeting involving the use of Bruton tyrosine kinase inhibitors and BAFF-R antagonists in the treatment of immune thrombocytopenia.CME information and select publications here.
Microlearning accelerates Gen AI education by delivering flexible, role-based, bite-sized training that boosts productivity, drives innovation, and builds a culture of continuous learning without disrupting daily operations. That's the key take-away message of this episode of the Wise Decision Maker Show, which discusses how microlearning offers a flexible approach to Gen AI education.This article forms the basis for this episode: https://disasteravoidanceexperts.com/microlearning-offers-a-flexible-approach-to-gen-ai-education/
Featuring perspectives from Dr Stacey A Cohen, Dr Christopher Lieu and Dr Jenny Seligmann, moderated by Dr Lieu, including the following topics: Neoadjuvant immunotherapy for localized rectal cancer (0:00) Surveillance in neoadjuvant immunotherapy for localized rectal cancer (8:14) Determining a treatment strategy for resectable colon cancer (12:35) CME information and select publications
Featuring perspectives from Dr Jaffer A Ajani, Dr Samuel J Klempner, Dr Rutika Mehta and Dr John Strickler, moderated by Dr Klempner, including the following topics: Younger patient with metastatic HER2-positive, PD-L1-positive gastric cancer (0:00) Older patient with metastatic HER2-positive gastroesophageal (GE) cancer (8:13) Clinical applications for zanidatamab in GE cancer (13:58) CME information and select publications
Featuring perspectives from Dr Paul G Richardson, including the following topics: Mechanism of action and pharmacology of cereblon E3 ligase modulators (0:00) Available efficacy data (4:54) Extramedullary disease (10:51) Side effects and toxicity (16:58) CME information and select publications
Dr Paul G Richardson from the Dana-Farber Cancer Institute in Boston, Massachusetts, discusses how CELMoDs function, available data with these agents and their possible future role in the treatment of multiple myeloma.CME information and select publications here.
Featuring an interview with Dr Hanny Al-Samkari, including the following topics: Case: A woman in her early 70s incidentally diagnosed with immune thrombocytopenia (ITP) experiences a suboptimal response to prednisone and IVIG — Bhavana (Tina) Bhatnagar, DO (0:00) Case: A man in his early 50s with a long history of ITP undergoes splenectomy — Neil Morganstein, MD (5:06) Case: A woman in her mid 50s with symptomatic iron-deficiency anemia who was found to have ITP has received corticosteroids, rituximab and IVIG — Jennifer Yannucci, MD (12:25) Case: A woman in her early 30s who previously received ABVD (doxorubicin/bleomycin/vinblastine/dacarbazine) and autologous stem cell transplant for Hodgkin lymphoma is diagnosed with ITP 5 years later that is refractory to high-dose prednisone, IVIG and rituximab, then romiplostim — Priya Rudolph, MD, PhD (18:19) CME information and select publications