Lungcast

An internationally recognized leader in air quality, epidemiology and exposure assessment, George Thurston, ScD, of New York University headlines this important episode analyzing the Lung Association's 2025 “State of the Air” report. With nearly half of the people living in the U.S. breathing unhealthy amounts of air pollution, Thurston delves into the acute and accumulative health impacts on communities across the country. Listen in to learn more about the report's key learnings, from adverse effects of exposure to ground-level ozone pollution to the decade-long worsening trend of particle pollution. Want more Lungcast? Visit us at HCPLive.com/podcasts/lungcast or www.lung.org/professional-education/lungcast

It has been more than a decade since lung cancer screening guidelines via low-dose CT, based on the USPSTF's B recommendations, have been put into place. To discuss the guidelines' ambitions and obstacles, we are joined by the University of Illinois Health System's Mary Pasquinelli, DNP, who specializes in lung cancer, lung cancer screening and pulmonary nodule management. While a lifesaving procedure for at-risk individuals, the uptake of screening on a population-level—though increasing—has been slower than expected. Want more Lungcast? Visit us at HCPLive.com/podcasts/lungcast or www.lung.org/professional-education/lungcast

For this hot topic, asthma and lung health expert Dr. Afif El-Hasan of Kaiser Permanente in California joins host Dr. Albert Rizzo to discuss the acute effects of wildfire smoke on air quality. The enlightening conversation also covers the massive cleanup efforts from the recent Los Angeles wildfires and how related exposures may pose health risks. Want more Lungcast? Visit us at HCPLive.com/podcasts/lungcast or www.lung.org/professional-education/lungcast

In this episode, Dr. Meredith McCormack of Johns Hopkins University and Dr. Loretta Que of Duke University to discuss “race-based normal values” in medicine, particularly in regard to pulmonary function tests (PFT). The controversial practice of using a patient's self-reported race to adjust a standard “normal” range has been shown to lead to potential misdiagnosis and healthcare disparities. Drs. McCormack and Que talk at length about their key roles in the growing movement to phase out a reliance on race in PFT interpretation. Want more Lungcast? Visit us at HCPLive.com/podcasts/lungcast or www.lung.org/professional-education/lungcast

Ever since the show first launched, Lungcast has provided pulmonologists and health care providers in general a chance to take part in ongoing conversations regarding lung health between experts, patients, and patient advocates. In this recap episode, the Lungcast team reflects on these conversations by highlighting some of the many interviews featured in 2024. The following are a set of examples of this year's interviews, though several other memorable episodes are not on this list. We hope you enjoy this set of highlights. For more, view a summary here: https://www.hcplive.com/view/this-year-in-pulmonology-a-2024-lungcast-recap Want more Lungcast? Visit us at HCPLive.com/podcasts/lungcast or www.lung.org/professional-education/lungcast

For a probing discussion detailing the American Lung Association's recent 2024 “State of Lung Cancer” report, we are joined by esteemed thoracic medical oncologist Dr. Jacob Sands of Dana-Farber Cancer Institute and Harvard Medical School. Offering insight into actionable targeted mutations, Dr. Sands addresses how precision oncology is fundamentally changing lung cancer diagnosis and treatment. The novel immunotherapy drugs, though proven to be safe and effective with significant improvements in response and survival rates, have challenges as well—this episode covers the gamut. Episode Highlights 0:00 Start 1:00 Topic of discussion 2:42 Introducing Jacob Sands, MD 3:39 NCCN guidelines for lung cancer 6:51 Recently-approved drugs for lung cancer 13:46 Patient responses to targeted mutations 17:58 Off-target side effects with drugs 21:34 State of Lung Cancer report 23:04 Estimated number of candidates for targeted therapies 26:13 Insurance coverage for biomarker testing 28:12 Other issues with ordering biomarkers 31:20 Closing comments 32:36 Outro Want more Lungcast? Visit us at HCPLive.com/podcasts/lungcast or www.lung.org/professional-education/lungcast

In this episode, multiple points of view are presented regarding Asthma Exacerbated Respiratory Disease (AERD). Lungcast host Albert Rizzo, MD, was joined by allergist and immunologist Mitchell Grayson, MD, of Nationwide Children's Hospital, as well as patient advocate Rhonda Nelson and her husband Wayne Nelson of The Little River Band. This discussion delves into the trials and tribulations of diagnosing—and living with—AERD, from disease misconceptions to daily management. Join the discussion as these guests focus specifically on the role of AI in chest imaging and uncover how these advancements are improving the future of patient care. Episode Highlights 0:00 Start 1:00 Focus of each guest 2:55 Sampter's triad and AERD 6:30 Patient experiences with AERD 10:18 Delayed diagnosis and recent changes 11:35 Therapy for AERD 16:32 Resources for patients with asthma 19:01 Day-to-day AERD management 24:14 Importance of keeping a medical journal 27:42 Outro Want more Lungcast? Visit us at HCPLive.com/podcasts/lungcast or www.lung.org/professional-education/lungcast

Episode Highlights 0:15 Intro 1:10 Introducing the Lung Health Cohort 3:49 The enrollment strategy 7:10 Seeking “the cholesterol of lung disease” 11:50 The role of industry support 14:09 Imaging strategies for long-term lung assessment 17:59 Recruitment challenges 23:05 Final thoughts 26:20 Outro For our 50th episode, Ravi Kalhan, MD, of Northwestern Medicine, George Washko, MD, of Harvard University, and Amy Olson, MD, Executive Director of Medical Affairs for Boehringer Ingelheim Pharmaceuticals, Inc, join us for a panel discussion around improving patient outcomes through innovative lung health research, such as with the American Lung Association Lung Health Cohort Research Study.  Tune in to learn more about their collaborative efforts to help identify biomarkers and lifestyle patterns for more accurate identification of disease processes, ideally at onset.  Want more Lungcast? Visit us at HCPLive.com/podcasts/lungcast or www.lung.org/professional-education/lungcast

In this episode, Dr. Rachel Eddy of the University of British Columbia explores the evolving field of medical imaging technology and the transformative impact of artificial intelligence. While applications of AI have expanded beyond traditional radiology, it delves into cutting-edge techniques like 3D printing and molecular imaging that are redefining diagnostics and treatment planning. Join us as we focus specifically on the role of AI in chest imaging and uncover how these advancements are improving the future of patient care. Episode Highlights 0:15 Intro 1:10 The history of medical imaging technology 3:02 Artificial intelligence terminology 8:56 Use of AI to assess asthma airway and mucus changes 13:02 Imaging biomarkers for ILD 16:52 Using AI to observe longterm decline of lung function 21:00 Dysanapsis analysis through CT scans 24:04 Xenon-enhanced MRIs for microstructural lung abnormalities 28:50 How will AI us continue to evolve in pulmonology? 31:58 Outro Want more Lungcast? Visit us at HCPLive.com/podcasts/lungcast or www.lung.org/professional-education/lungcast

Episode Highlights 0:16 Intro 2:24 Asthma action plans 3:52 Asthma Peak Week 6:28 School nurse's role 11:05 SMART inhaler strategy for kids 14:25 Addressing vaping among students 20:18 Discussing vaccines with children and parents 24:01 School air quality issues? 27:50 Final thoughts 29:42 Outro As families jump into the new school year, this episode brings together Chicago-based allergist and immunologist Dr. Juanita Mora and pediatric pulmonologist Dr. S. Christy Sadreameli of Johns Hopkins Hospital to share their tips for making the return to school as smooth as possible in regard to lung health.  The lively conversation homes in on asthma control and the phenomenon often referred to as ‘peak week,' along with the prevalence and hazards of vaping and e-cigarettes affecting the school aged population. Grab your pencils and take notes! Want more Lungcast? Visit us at HCPLive.com/podcasts/lungcast or www.lung.org/professional-education/lungcast

Episode Highlights 0:15 Introduction 2:35 Introducing Janelle Bludorn, MS, PA-C 3:27 Common heat-related illnesses 8:43 How to screen for individual health-related risks 15:27 Respiratory consequences of heat 19:49 The interplay of medicines with heat 26:49 National Weather Service HeatRisk tool 32:58 Behavioral interventions for heat-risk patients 36:27 A FEMA system for heat emergencies? 38:10 Outro For our July episode, we are visited by Duke University's Janelle Bludorn, PA-C, MS, for a comprehensive overview of heat-related respiratory illnesses.  Due to climate change in all regions around the world, extreme heat has become a significant environmental and occupational health hazard with heatstroke classified as a medical emergency. Listen in to better understand the serious risks of exposure to high temperatures. Want more Lungcast? Visit us at HCPLive.com/podcasts/lungcast or www.lung.org/professional-education/lungcast

Episode Highlights 0:15 Intro 3:39 Update in pre-lung cancer genome atlas research 17:06 Next steps: applying innovations in bronchoscopy 21:45 When we can anticipate results 25:05 Understanding the lung's microbiome 29:21 Utility of fragmentomics 31:01 Outro Dr. Steven Dubinett at University of California, Los Angeles and Dr. Avrum Spira at Boston University revisit our virtual studio to provide an update on their lung cancer interception research, as currently funded by the American Lung Association and LUNGevity Foundation. With the goal of combating cancer at a preliminary stage, Drs. Dubinett and Spira are focused on refining molecular and imaging markers to help identify high-risk premalignant lesions. These findings hope to lead to future therapeutics halting the progression of cells likely to cause invasive cancer. Want more Lungcast? Visit us at HCPLive.com/podcasts/lungcast or www.lung.org/professional-education/lungcast

0:16 Intro 2:29 Updated community-acquired pneumonia guidelines 5:41 Diagnostic tools for CAP following COVID-19 9:35 Procalcitonin levels as a biomarker 12:30 The CAP treatment algorithm 18:36 Best practices for antibiotic stewardship 20:40 New CAP therapies on the horizon 22:36 ACIP recommendations for vaccination 24:30 Remaining areas of CAP uncertainty 26:30 Final thoughts 27:25 Outro Featuring infectious disease expert Dr. Thomas File of Summa Health in Ohio, this episode delves into how community-acquired pneumonia has been affected by the COVID-19 pandemic. It additionally covers the role and importance of antibiotic stewardship and the concern of ‘superbugs' due to antimicrobial resistance. Want more Lungcast? Visit us at HCPLive.com/podcasts/lungcast or www.lung.org/professional-education/lungcast

Episode Highlights 0:11 Intro 1:05 Introducing Stephanie Lovinsky-Desir, MD, MS 2:09 Understanding asthma endotypes and phenotypes 5:03 The effect of SMART guideline updates 11:50 Are pulmonary & allergy specialists adopting it? 12:46 The value of biologics in asthma care 18:11 Could they interrupt the atopic march? 19:53 COVID-19 risks in asthma 23:24 Environmental and non-viral illness impacts on asthma 26:11 Research into asthma care inequities 31:47 HFA-containing metered dose inhalers 35:37 Outro In honor of World Asthma Day, Dr. Stephanie Lovinsky-Desir of Columbia University Irving Medical Center in New York visits our virtual studio to talk about all things asthma. Dr. Lovinsky-Desir, who has a deep understanding of how environmental factors impact children with asthma, touches upon inequities in asthma care, the role of climate change and COVID-19 lessons learned. She also hones in on whether biologic therapies may help interrupt pathways in the atopic march. Want more Lungcast? Visit us at HCPLive.com/podcasts/lungcast or www.lung.org/professional-education/lungcast

Episode Highlights 0:16 Intro 2:17 What caused the particle pollution spike? 6:28 The health effects of fine particle pollution exposure 10:23 The new EPA particle pollution standard 14:27 Improvements to ozone pollution and the Clean Air Act 18:46 How to advocate for improvement 20:23 Air quality inequity 24:03 Reflecting on 25 years, and looking ahead 25:52 Outro  Dr. John Balmes, a renowned environmental health sciences expert from the University of California, San Francisco, join Lungcast for a deep dive into the American Lung Association's newly released 2024 “State of the Air” report. Balmes specifically provides context behind several concerning trends, notably a spike in deadly particle pollution—the highest levels in the past 25 years largely due to wildfires.  The eye-opening conversation also impresses upon the importance of clean transportation and power generation to help mitigate population-wide risk.  Want more Lungcast? Visit us at HCPLive.com/podcasts/lungcast or www.lung.org/professional-education/lungcast

0:16 Intro 2:28 Recent modifications to the lung allocation score 5:11 Monitoring chronic graft rejection 9:23 The rising use of ex vivo lung perfusion  16:17 The presence of post-COVID patients on the lung transplant waitlist 21:01 Impact of long Covid on transplant rehabilitation 22:51 Double lung transplant in bilateral lung cancer—what's the future? 26:52 Effect of LAS on lung transplant survival racial disparity 31:05 What lies ahead in the practice of lung transplantation 35:00 Outro Cleveland Clinic's Maryam Valapour, MD, MPP, rejoins the broadcast, along with her colleague Kenneth McCurry, MD to discuss optimization of the lung allocation system to continue reducing waitlist times and patient mortality.  It includes commentary on how recent changes to scoring protocols are expected to impact ongoing disparities related to race and socioeconomic status. They additionally talk about the role of transplantation in patients who have severely damaged lungs resulting from COVID-19 infection, an update since our April 2021 conversation. Want more Lungcast? Visit us at HCPLive.com/podcasts/lungcast or www.lung.org/professional-education/lungcast

Episode Highlights 0:15 Intro 3:09 Low-dose CT screening uptake in Canada 4:45 Evolution of adjuvant, neoadjuvant therapies 7:10 Reviewing CheckMate 816 10:56 Reviewing KEYNOTE-671 12:58 The impact of neoadjuvants on operability 16:15 Treatment-specific biomarkers for lung cancer 21:13 The short-term future of lung cancer therapy 24:31 Outro Precision medicine–delivering the right drug at the right time to the right patient–is the direction in which lung cancer treatment is heading. In this episode, we talk about an exciting, emerging drug class with one of the most prominent investigators involved with its development, Dr. Jonathan Spicer at McGill University's Thoracic Oncology Network.  It provides a deep dive into neoadjuvant therapy for patients who have operable lung cancer, offering insight into what is currently known about response and failure rates. Want more Lungcast? Visit us at HCPLive.com/podcasts/lungcast or www.lung.org/professional-education/lungcast

Episode Highlights 0:15 Intro 1:48 Remembering the 1964 Surgeon General Report 3:01 The impact of the report on cardiology 6:47 The strategies and impact of anti-smoking campaigns 10:33 The modern vaping challenge 17:38 Outro In recognition of 60 years since the 1964 Surgeon General Report—a historic contribution to our understanding of the negative health impacts of cigarette smoking—host Albert Rizzo, MD, meets with preventive cardiology expert Viet Le, DMSc, PA-C to reflect on the myriad of cascading effects delivered by this landmark report. Want more Lungcast? Visit us at HCPLive.com/podcasts/lungcast or www.lung.org/professional-education/lungcast

Episode Highlights 0:15 Introducing Sue Padernacht, EDd, PCC 1:16 The definition of burnout 3:53 The history of burnout 7:45 Differences between stress and burnout 14:34 Physical and behavioral signs of burnout 20:55 Steps the health care industry can take against burnout We are beginning 2024 with a matter that extends beyond the confines of pulmonary medicine and really has become something of a crisis in the U.S. healthcare system over the last decades. Organizational psychology expert Dr. Sue Padernacht joins Lungcast to provide an in-depth look into physician burnout—what are its drivers, what factors are exacerbating it, and how the collective medical community can work toward curbing its effect among caregivers. Want more Lungcast? Visit us at HCPLive.com/podcasts/lungcast or www.lung.org/professional-education/lungcast

Episode Highlights 0:16 Intro 1:44 How to approach stage IV lung cancer, with Dr. David Tom Cooke 4:13 The ALA Lung Health Cohort Research Study, with Dr. Ravi Kalhan 8:42 What is the atopic march, with Dr. Payel Gupta 10:53 Weight loss for asthma care, with Dr. Anne Dixon 15:11 Air Quality Index 101, with Dr. Al Rizzo 18:47 Lung Cancer Age Equity, with Dr. Carolyn Presley 21:45 The emerging treatments for long Covid, with Dr. Julia Moore Vogel 24:28 The future of pulmonary embolism care, with Dr. Parth Rali 28:08 The modern fight against RSV, with Dr. Barbara Taylor 33:26 Detecting unhealthy air exposure, with Dr. Mark Hernandez 36:12 Living while fighting lung cancer, with Christy Fischer 38:51 Outro Though some subjects are clear favorites, it is nearly impossible to select a single answer to the question, “What was the biggest story in pulmonology this year?”  Since the American Lung Association (ALA) and HCPLive launched Lungcast in the summer of 2020, the field of respiratory health has evolved in unprecedented fashion. One doesn't have to look further than the show's episode library to appreciate the great shifts in the field—brought on by a global pandemic, numerous public health phenomena, and practice-changing innovations in screening, diagnostics, prevention and therapy. From vaccination to late-stage lung cancer care, the world of respiratory health is irrevocably changed from just a short span of 4 years. To reflect on this year's spectacular headlines in the field, HCPLive presents the annual recap episode in conjunction with This Year In Medicine, where the Lungcast team reflects on their favorite interview segments of 2023. Subscribe to Lungcast on YouTube: https://www.youtube.com/@Lungcast Want more content? Visit us at https://www.hcplive.com/podcasts/lungcast and https://www.lung.org/professional-education/lungcast.

For this episode fully focused on indoor air pollution, we are joined by Professor Mark Hernandez who serves as director of the Aerobiology and Disinfection Lab at the University of Colorado. Listen in to learn about the harmful impact of pollutants such as mold, toxic chemicals and asbestos on respiratory health, particularly in a school setting. Equally important, what can be done to help alleviate these effects? Episode highlights 0:16 Intro 0:50 Introducing Mark Hernandez, PhD, PE 2:15 The most pressing issues of school air quality 4:12 Advice for school administrators 6:25 The link to pediatric asthma 12:23 Trends in national monitoring 14:16 How COVID-19 changed ventilation priorities 16:29 An equitable, affordable solution 18:34 Signs of unhealthy air exposure 20:53 How clinicians and guardians can get involved 23:47 Outro Want more Lungcast? Visit us at HCPLive.com/podcasts/lungcast or www.lung.org/professional-education/lungcast

Christy Fischer, a miraculous 17-year stage IV lung cancer survivor, connects with us to discuss stress, stigma and significant changes in the treatment landscape. Hear how Christy transformed a daunting diagnosis into hope for others. This educational and inspirational episode touches upon the raw emotions of what it is like to live (and thrive!) with advanced cancer. Episode Highlights 0:17 Intro 1:55 Christy's first diagnosis 3:53 Reacting to Stage IV lung cancer 5:28 Initiating treatment 7:18 The lung cancer stigma 9:51 Finding the right doctor 11:16 How lung cancer care changed over 17 years 14:20 Clinical trial participation 16:51 Becoming an advocate 20:33 Advice for physicians diagnosing lung cancer 22:18 How to keep living after diagnosis Want more Lungcast? Visit us at HCPLive.com/podcasts/lungcast or www.lung.org/professional-education/lungcast

With cases of Respiratory Syncytial Virus (RSV) on the rise this fall, Dr. Barbara Taylor, professor of infectious diseases at UT Health San Antonio, joins us for this timely episode all about RSV. Importantly, she covers the unprecedented events of the 2022-2023 season that was marred by a ‘tripledemic' of respiratory diseases.  How do the lessons learned change the preventive approach to better protect against the deadly infection?   Episode Highlights 0:16 Intro 0:48 The burden of RSV today 2:11 Transmission, presentation and diagnosis of RSV 4:33 Likelihood of an RSV, COVID-19, flu “triple-demic” 7:35 The history of RSV vaccine development 12:09 Risk of RSV mutation and variants 14:19 The new RSV vaccines 20:09 Spacing the RSV vaccine with other seasonal shots 22:14 Age and comorbidities as vaccine criteria 24:30 In vitro immunization 27:39 Nirsevimab and monoclonal antibodies for RSV 29:31 Using the full toolset against RSV 31:50 Yearly COVID-19 vaccine updates? 33:24 A universal flu vaccine? 37:20 Outro Want more Lungcast? Visit us at HCPLive.com/podcasts/lungcast or www.lung.org/professional-education/lungcast

Pulmonary vascular disease expert Dr. Parth Rali at Temple Lung Center helps break down what is known about massive and submassive pulmonary emboli (PE), namely blood clots. This episode provides a comprehensive overview of PE, from the complications of diagnosis to the evolution of therapeutic modalities. Episode highlights 0:16 Intro 2:34 Defining pulmonary embolism classifications 8:18 The Pulmonary Embolism Severity Index 15:47 The role of D-dimer in diagnosis 17:08 Anticoagulation strategies 22:26 The Pulmonary Embolism Multidisciplinary Response Team 25:38 Long-term outlooks for acute PE 31:38 When to stop anticoagulation 35:27 The future of PE diagnosis and treatment 38:50 Outro Want more Lungcast? Visit us at HCPLive.com/podcasts/lungcast or www.lung.org/professional-education/lungcast

In this must-listen episode, Dr. Julia Moore Vogel at Scripps Research takes center stage to confer the still-emerging and always-evolving space of long COVID. As patient numbers continue to rise at an alarming rate, she makes a strong case about the critical need to better define the disease, mitigate its impact and, ultimately, break the taboo. Episode highlights 0:15 Introduction 1:27 Moore Vogel's background in Long Covid 4:30 Lacking terminology in Long Covid 6:20 Quantifying Long Covid disease 8:38 The mechanism of action: what we know 10:27 Pediatric Long Covid 16:00 Similarities to post-viral syndromes 16:58 Key diagnostic tools 18:37 The current Long Covid treatment landscape 20:57 Influence of SARS-CoV-2 variants and vaccines 22:02 Considering social determinants of health 23:35 Needs for professional and public education 27:00 Final thoughts 28:28 Outro Want more Lungcast? Visit us at HCPLive.com or Lung.org.

For this episode focusing on the role of medical oncology, we are joined by Dr. Carolyn Presley, thoracic oncologist and associate professor with tenure at Ohio State University. As a geriatric expert, she provides a poignant point-of-view on the need for a multidisciplinary approach to patient care, as well as advances in treatment that include targeted therapies.

Amid mass poor air quality exposure due to ongoing Canadian wildfires, Lungcast host and ALA Chief Medical Officer Albert Rizzo, MD, explains air quality index (AQI), signs and symptoms of acute and long-term poor air exposure, high-risk patient populations, and the concerning future of particle pollution exposure. Want more Lungcast? Visit us at HCPLive.com or Lung.org. Episode Highlights 0:15 Intro 1:23 What is the Air Quality Index? 3:14 Risk factors of poor air quality 4:30 Acute signs and symptoms 6:42 Recommendations for patients with pre-existing conditions 8:09 How long will this last? 10:28 When to resume livelihood 11:12 The long-term impact of air pollution exposure 14:02 Outro

Anne Dixon, MD, Director of Pulmonary and Critical Care Medicine at University of Vermont Medical Center and the first repeat guest in the history of Lungcast, rejoins American Lung Association Chief Medical Officer Albert Rizzo, MD, on the floor at the American Thoracic Society (ATS) 2023 International Conference in Washington, DC, to discuss headline news from the annual meeting and her ongoing work in clinical airway research. Want more Lungcast? Visit us at HCPLive.com or Lung.org. Episode Highlights 0:15 Intro 1:00 Obesity burdens in asthma 3:22 Weight loss intervention data at ATS 2023 4:53 ALA grants program 7:00 Airways Clinical Research Network 10:52 Seeking research collaborators 12:46 Merging clinicians, patients and industry in innovative research 13:54 Outro

Just in time for May's Asthma and Allergy Awareness Month, allergist and immunologist Dr. Payel Gupta of LifeMD.com headlines a conversation about the clinical presentation of asthma and its role in the atopic march. She also details various phenotypes, endotypes and other molecular mechanisms of asthma that can be applied to help guide disease management and treatment decisions. Episode highlights 0:15 Intro 1:16 Introducing Payel Gupta, MD 2:31 Classifications of asthma 5:35 What is the atopic march? 8:46 The bridge from allergy testing to immunotherapy 12:00 How to initially diagnose asthma 16:02 When to add secondary therapies 18:11 Biologics for uncontrolled asthma 23:20 Real-world use of the SMART therapy guidance 25:40 Assuring asthma treatment adherence 28:35 Addressing asthma care disparities 32:26 The future of asthma research 33:58 Outro Check out other allergy and/or asthma episodes of Lungcast: Poor Indoor Air Quality Exposure and Clinical Risks with Edward Brooks, MD, and Charlene McEvoy, MD How PREPARE Data, SMART Recommendations Alter Modern Asthma Strategy Fighting Disparities in Pediatric Asthma Care with Dr. LeRoy Graham Get More From Lungcast Lungcast on HCPLive: https://www.hcplive.com/podcasts/lungcast Lungcast on American Lung Association: https://www.lung.org/professional-education/lungcast Spotify: https://spoti.fi/3YEDxKw Apple Podcasts: http://bit.ly/3jCVevq YouTube: https://www.youtube.com/@Lungcast/videos

For our 30th episode of Lungcast™, pulmonologist Dr. Ravi Kalhan of Northwestern Medicine joins for a core-level discussion on the modeling of respiratory health and pulmonary mechanisms.  In addition to sharing how a novel machine learning method may one day soon predict lung disease susceptibility, Dr. Kalhan describes the science behind the American Lung Association Lung Health Cohort Research Study.

David Tom Cooke, MD, Founding Chief of the Division of General Thoracic Surgery at UC Davis, joins the first episode of 2023 to discuss his colleague's specific role in lung cancer screening and intervention, advances to minimally invasive, robotic and bronchoscopic techniques, and evolving strategies in individualized patient care. Episode Highlights 0:14 Intro 1:52 Introducing David T. Cooke, MD 3:23 The role of thoracic surgeons in improving lung cancer screening rates 6:22 Shared decision making in thoracic surgery 8:16 Lobar, wedge resection or segmentectomy? Plus, robotic techniques? 12:22 PET/CT scans in the staging process 13:52 The surgeon approach to stage IV lung cancer 16:02 Patient follow-up—improved mortality and longer life expectancy 18:50 Prioritizing surgery and neoadjuvant therapy regimens 20:48 Thoracic surgeon role in palliative care 22:57 What's on the horizon in the field: robotic surgery 24:17 Outro Check out other lung cancer episodes of Lungcast: Innovations in Interventional Pulmonology with Dr. Carla Lamb  Lung Cancer Screening: Trials, Tribulations & Triumphs with Dr. James Mulshine Future of Lung Cancer Precision Medicine with Andrea Mazzochi Get More From Lungcast Lungcast on HCPLive: https://www.hcplive.com/podcasts/lungcast Lungcast on American Lung Association: https://www.lung.org/professional-education/lungcast Spotify: https://spoti.fi/3YEDxKw Apple Podcasts: http://bit.ly/3jCVevq YouTube: https://www.youtube.com/@Lungcast/videos

Will your New Year's resolution kick off the journey to quit smoking? In our final Lungcast™ interview of 2022, Bob Levey, former Washington Post columnist and founder of the Super Stoppers Club, and the Lung Association's national senior director of tobacco programs, Jennifer Folkenroth, come together to review the intricacies of smoking cessation. The lively and informative discussion outlines the path to a smoke-free life, which is often riddled with hurdles and stressors. 0:16 Ernst Wynder, Evarts Graham and the discovery of smoking - lung cancer risk 1:52 Introducing Jennifer Folkenroth and Bob Levey 4:46 Bob Levey and the Super Stoppers Club 11:25 The clinical effect of group cessation 14:00 Why is it hard to quit smoking? 17:45 The value of cessation support systems and social groups 20:03 Navigating patient concerns around cessation treatments 21:54 Combating stigma and social trends 26:35 Resources for aspiring quitters 31:26 Outro

Among many unintended and unexpected effects of sheltering in place during the COVID-19 pandemic is the substantial increase in exposures to indoor allergens and pollutants. Here, Dr. Edward Brooks at University of Texas at San Antonio and Dr. Charlene McEvoy at University of Minnesota bring a shared expertise on air quality health and research to discuss the resulting health ramifications. It is an enlightening conversation about the patient populations who are most impacted, plus what can be done to help mitigate the consequences. Episode highlights 0:16 The history of indoor air environments 2:50 Introducing Edward G. Brooks, MD, and Charlene McEvoy, MD 4:39 The factors of poor indoor air quality 6:25 Ways to improve indoor air quality 8:59 The underlying pathophysiology of pollutants 13:02 Benzene recalls 14:18 High-risk behaviors and disease risks 17:14 Recommendations for exposed patients 21:02 Radon as a lung cancer risk 22:35 Final thoughts 25:42 Outro For additional news and insights, visit us at HCPLive.com and Lung.org.

Episode highlights 0:16 Alan Turing and the advent of artificial intelligence 2:19 Challenges and needs in IPF 3:13 Introducing Simon Walsh, MD, and Elizabeth Estes 3:58 Evolving IPF diagnostics 7:31 Multidisciplinary teams and centers for IPF 9:52 OSIC's use of AI and deep learning in IPF 12:36 The inception of OSIC 17:09 Pursuing AI opportunities in pulmonology 21:03 Applying data to clinical research 27:06 Project Opus 33:20 Final thoughts 37:21 Outro For additional news and insights into respiratory health, be sure to visit us at HCPLive.com and Lung.org.

Modern obstructive sleep apnea presents an under met challenge in pulmonary health. This episode, featuring Dr. Reena Mehra at Cleveland Clinic, delves into the ins and outs of this surprisingly common disease that is practically defined by its hefty symptom burden. Listen in to learn more about sleep apnea's improved diagnostics and advancing therapies, as well as the role of comorbid conditions. Episode highlights 0:16 The origin of sleep apnea diagnosis 1:48 Current sleep apnea burden in the US 3:16 Defining obstructive sleep apnea 4:40 The OSA pathophysiology 8:36 Clinical characteristics of OSA 11:16 Role of head and neck anatomy 12:30 Pros and cons of home sleep studies and polysomnography 16:11 Benefit of the Apnea-Hypopnea Index 21:55 The interplay of cardiovascular disease 23:41 The importance of PAP adherence 28:35 Addressing daytime somnolence 32:36 Additional OSA therapy options 35:55 How much weight should patients lose? 36:39 Future diagnosis and treatment 38:25 Outro For additional news and insights, visit us at HCPLive.com and Lung.org.

Dr. Carla Lamb at Beth Israel Lahey Health joins us to discuss her role in developing early interventional pulmonary training and recommendations, the utility of key diagnostic tools in the subspecialty, evolving roles for lung cancer treatments including bronchial stents, modernized COPD intervention and research, and the future of interventional pulmonary medicine. It is an information-packed interview! Episode highlights 0:16 Intro 1:49 The history of the interventional pulmonology subspecialty 7:12 The Rescue Lung, Rescue Life Society 10:04 Technological advances to low-dose CT scan accuracy 17:04 Utility of bronchial stents in lung cancer care 21:55 Bronchial thermoplasty in asthmatic patients 26:01 Assessing a COPD patient for volume reduction 32:58 Rheoplasty and targeted lung denervation 35:39 Cryobiopsy in ILD 38:58 The future of interventional pulmonology 42:35 Outro For additional news and insights, visit us at HCPLive.com and Lung.org.

In recognition of May's Asthma Awareness Month, this episode highlights our conversation with Dr. Juan Carlos Cardet at University of South Florida and Dr. Elliot Israel at Brigham and Women's Hospital about the most common respiratory disease in the U.S. It provides a deep dive into the guideline-supported SMART strategy, role of COVID-19 in current asthma risks, and research into the medical and financial impacts of asthma on the U.S. patient population. Episode highlights 0:16 The Discovery of Asthma 2:12 Introducing Elliot Israel, MD, and Juan Carlos Cardet, MD, MPH 3:20 Defining the SMART asthma strategy 5:46 The slow rollout of SMART 10:19 The strategy and findings of the PREPARE trial 21:41 How to initiate patient-activated reliever-triggered inhaled corticosteroid 25:15 The effect of COVID-19 on real-world asthma trials 27:40 How to lessen the disparities of asthma 31:14 Outro For additional news and insights, visit us at HCPLive.com and Lung.org.  

The Director of the ILD and Sarcoidosis Program at the Jacksonville College of Medicine joins Dr. Al Rizzo during Sarcoidosis Awareness Month to review the challenges and research surrounding the rare inflammatory disease. Episode highlights 0:16 The history of sarcoidosis 1:54 Introducing Mehdi Mirsaeidi, MD, MPH 2:54 Understanding inflammatory process in sarcoidosis 5:01 How advanced sarcoidosis presents in clinics 8:34 Anti-inflammatories for sarcoidosis 12:10 The role of lung transplantation 14:27 COVID-19 complications among patients 16:42 The sarcoidosis specialty care team 18:13 Clinical research endeavors 19:36 Outro For additional news and insights, visit us at HCPLive.com and Lung.org.  

For decades, scientists have hypothesized about a future when diseases could be treated with gene editing techniques. The reality is getting closer to fruition! In this fascinating episode, Drs. Eric Kmiec and Natalia Rivera-Torres at ChristianaCare's Gene Editing Institute share the latest developments in DNA alteration and explain why CRISPR gene editing continues to offer the most promise.  They also detail how their lab's pioneering work in squamous cell carcinoma is leading to what will be the first-ever lung cancer patient trial using CRISPR gene editing in a solid tumor. Learn more about lung cancer screening at HCPLive.com and Lung.org.

Continuing Black History Month, esteemed pediatric pulmonologist Dr. LeRoy Graham of Bridge Atlanta Medical Center drops by to discuss the disparities that continue to exist in childhood asthma. With a 40-plus history helping underserved communities, this easy-to-digest episode hits many high points about improving access to asthma care. Learn more about lung cancer screening at HCPLive.com and Lung.org.

In recognition of Black History Month, we are joined byinternationally acclaimed sickle cell disease expert Dr. Ify Osunkwo at Atrium Health to address stigma, mistrust and disparities. Born in Nigeria, she shares her unique perspectives on the genesis of this genetic disorder and its inequitable public health impacts. Check out the episode for an interesting overview of a storied disease. Learn more about lung cancer screening at HCPLive.com and Lung.org.

For the first episode of 2022, we welcome Dr. Gerald Criner at Temple University to summarize key highlights of recent clinical trials and research studies in the COPD field. Additionally, he outlines his work on the development of non-surgical techniques for patients who have advanced COPD. What have been the greatest impacts? Hurdles? Listen and learn. Learn more about lung cancer screening at HCPLive.com and Lung.org.

Join Dr. Al Rizzo for an end-of-year recap of the best highlights from Lungcast this year, featuring perspectives on COVID-19, asthma, lung cancer, tuberculosis, flu, and more.

With flu season upon us, Dr. Shantanu Agrawal, Chief Health Officer of Anthem Inc., joins us on behalf of their philanthropic arm, Anthem Foundation, to converse about the importance of flu vaccines as a key social driver of health. This episode explores the various vaccination modalities and related public health guidelines, as well as how our joint Fund Off Flu campaign aims to increase influenza knowledge and vaccination rates.

In recognition of Lung Cancer Awareness Month, this episode featuring Dr. James Mulshine at Rush University explains the ins and outs of the improved 2021 lung cancer screening guidelines. While a big step in the right direction, complexities and challenges of equitable access to low-dose CT scans continue to persist, plus the profound impact of the COVID-19 pandemic on screening rates. Learn more about lung cancer screening at HCPLive.com and Lung.org.

Interstitial lung disease, which prominently includes idiopathic pulmonary fibrosis, is a very broad category of chronic lung conditions with considerable nuance. To help break it down within the context of diagnosis and treatment, Dr. Marilyn Glassberg at University of Arizona joins us to discuss the roles of biomarkers, biopsies and drugs. This episode also sheds light on multidisciplinary clinics and stem cell therapy. Learn more about ILD and IPF at HCPLive.com and Lung.org.

In this timely episode, we are joined by infectious disease experts Dr. Michael Greenberg of Sanofi Pasteur and Dr. Richard (Rick) Nettles of Johnson & Johnson to discuss respiratory virus immunization.  It touches upon many hot topics, including the inadvertent health consequences of the pandemic. Additionally, they offer fascinating insight into how unprecedented collaboration and transparency have raised the research bar.

Dr. Castro and Dr. Rizzo discuss the evolving world of monoclonal antibodies for the treatment of severe asthma. Plus, the ALA team discusses September's annual Asthma Peak Week, and what it means for reopening schools. See and read more Lungcast recaps and additional interviews at HCPLive.com/sap-partner/american-lung-association. Listen to Dr. Rizzo's interview with Dr. Anne Dixon on the 2020 asthma management guidelines here. Visit Lung.org for more resources and expert insights into respiratory disease management. Episode highlights 0:15 Back to school with Asthma Peak Week 9:48 Biologics: the emerging severe asthma treatment field 11:34 Defining type 2 inflammation and severe asthma 15:47 Severe asthma biomarkers 21:23 IL-4, IL-13, TSLP: Promising pathways 25:49 Severe asthma diagnostic clues 28:34 Asthma biologic decision-making 35:31 How long-term is a biologic therapy? 37:44 The future of asthma-modifying therapy 41:09 Understanding asthmatic COVID-19 risk 44:57 Outro

Data beget progress. Such is the promise and hope of artificial intelligence, particularly machine learning, to match lung cancer patients with their optimal treatments. In this episode, Dr. Andrea Mazzocchi, Co-founder and CEO of Known Medicine, dissects the art and the science of how profiling biomarkers, epigenetics and the microenvironment may provide the synergy needed to revolutionize the oncologic landscape.

The NIH expert joins to highlight the most recent science and understood harms of current e-cigarette devices—and his team's work toward a standardized option for users.

A couple of climate change health experts and advocates join for a timely discussion on the clinical impact of pollution and air quality.