Podcasts about Estes

I've been told that if I were in a horror movie, I would die first. But can I help it if I'm curious, chaotic, and solitary? Anyway, here's a look at some solo paranormal investigations I did around Halloween 2021 in two North Carolina state parks: Eno River State Park in Durham and William B. Umstead State Park in Raleigh. Highlights include: - phantom footsteps - a breath on my neck while I was alone - an abandoned house in the woods  - a solo Estes session in an environment where I was being told fairly clearly that I wasn't wanted Sign up for my newsletter!

On this episode of The Residuals, Joy has a book report on the (in)famous Stanley Hotel in Estes Park, Colorado. This hotel was made famous by Stephen King as inspiration for his book The Shining. Take a deep dive with our hosts into the history of the Estes valley where we learn about its links to the spirit world via indigenous peoples & the energetic footprint left by industrious early Americans. Then keep your earholes peeled for part two when Emily will share the paranormal stories of the Stanley Hotel. Enjoy! * * * * * * * * * * * * * Between the present & past there are memories held in the walls & earth. Join Emily & Joy as they explore the spaces between the living & the dead. Hauntings, extrasensory perception, & all things paranormal. Welcome to The Residuals. email: TheResidualsPodcast@gmail.com instagram: @the_residuals_podcast music: purple-planet.com   ©2023

Boston rock legends Jon Butcher, Sal Baglio and Allen Estes have collaborated on a new album called Gypsy Caravan. Learn more at www.butcherbaglioandestes.com.

00:00 – 25:20 – Jimmy and Brendan open the show by talking about the NFL Divisional Round, and if any of the games moved the needle on potential head coaching candidates for the Colts. They get into what they are looking for in a head coach, like prior head coaching experience. They talk about some of the candidates the Colts could be considering, like the Bengals OC Brian Callahan.     25:21 – 40:50 – Don Fischer, voice of the Indiana Hoosiers, joins the show to dive into Indiana's recent turnaround the last 3 games, including nice wins over Illinois and Michigan State. Don talks about what has led to this turnaround, and how the team has managed to step up despite having two key players injured. They also talk about where the team can go from here.     40:51 – 47:45 – Jimmy and Brendan close out the first hour by talking about some breaking NBA trade news, as well as if we could see Myles Turner being traded away anytime soon.     47:46 – 1:15:08  – Casey Vallier from the Colts Radio Network joins Brendan and Jimmy as the dive into the NFL Divisional round and what they took away from those games. They get into what the Colts are looking for in their next head coach, and how the team is doing its due diligence in interviewing a large number and variety of candidates. They also talk about what type of coach they would like to see, whether it's an offensive or defensive minded coach, as well as what pieces on the Colts roster could be attractive to potential candidates.     1:15:09 – 1:31:20 – Beau Estes from NBATV and NBA.com joins the show to get into the Lakers trade news that broke earlier today. Jimmy, Brendan, and Beau get into the Pacers, and whether they are further along in their rebuild than initially expected. They also talk about how it's no coincidence that the Pacers have begun to struggle since Tyrese Haliburton went out with an injury.     1:31:21 – 1:39:33 – Jimmy and Brendan close out the 2nd hour by reviewing the Divisional round of the NLF playoffs, as well as looking ahead to next weekend and the Conference Championship games! They also talk about the Pacers and their losing streak.     1:39:34 – 2:04:35 – ESPN's Coach Seth Greenberg joins Jimmy and Brendan to kick off the 3rd and final hour to discuss college hoops, including whether or not the Hoosiers have truly gotten out of their funk. They get into whether its surprising or not that at this point in the season there is only 1 ranked Big 10 team. They then talk about the Purdue Boilermakers, and the expectations surrounding them, as well as the head coaching opening at Notre Dame.     2:04:36 – 2:15:46 – Howard Kellman, the voice of the Indianapolis Indians, joins the show to shift the conversation to baseball! They talk about news around baseball, and give their opinions on the pitch clock and automated strike zones.     2:15:46 – 2:28:41 – Jimmy and Brendan close out the show by giving the JCook Plays of the Day, as well as taking a final look at the Colts coaching search.        See omnystudio.com/listener for privacy information.

Darkness Radio presents Catching Up with Kindred Spirits with Amy Bruni, Adam Berry, & Chip Coffey! Amy Bruni, Adam Berry, and Chip Coffey are returning to Discovery Plus and Travel Channel on Friday, January 20th, 2023, with season seven of their hit paranormal investigation show, Kindred Spirits! All three join Darkness Radio today to talk about the beginning of Season Seven, the growing dynamic between the three of them, the unusual theme that runs through this season, and that little extra something that is happening when Amy and Adam employ the Estes method of using the Spirit Box on an investigation! Don't have Discovery Plus yet? subscribe at this link:  https://www.discoveryplus.com/ Are you a lover of the unknown? Would you like the opportunity to get away and investigate with Amy and Adam check out Strange Escapes:  http://www.strange-escapes.com/ Meet Amy, Adam, and Chip at Michigan Paracon in August 2023:  https://saultstemarie.com/events-calendar/michigan-paranormal-convention/ #paranormal  #supernatural  #metaphysical  #paranormalpodcasts  #darknessradio  #timdennis #kindredspirits #amybruni #adamberry  #chipcoffey  #ghosts  #spirits  #hauntings #hauntedhouses #haunteddolls #demons #deliverances #exorcisms #angels #guardianangels #spiritguides #Psychics #mediums #tarot  #ouija #shadowpeople #discoveryplus #travelchannel

Darkness Radio presents Catching Up with Kindred Spirits with Amy Bruni, Adam Berry, & Chip Coffey! Amy Bruni, Adam Berry, and Chip Coffey are returning to Discovery Plus and Travel Channel on Friday, January 20th, 2023, with season seven of their hit paranormal investigation show, Kindred Spirits! All three join Darkness Radio today to talk about the beginning of Season Seven, the growing dynamic between the three of them, the unusual theme that runs through this season, and that little extra something that is happening when Amy and Adam employ the Estes method of using the Spirit Box on an investigation! Don't have Discovery Plus yet? subscribe at this link:  https://www.discoveryplus.com/ Are you a lover of the unknown? Would you like the opportunity to get away and investigate with Amy and Adam check out Strange Escapes:  http://www.strange-escapes.com/ Meet Amy, Adam, and Chip at Michigan Paracon in August 2023:  https://saultstemarie.com/events-calendar/michigan-paranormal-convention/ #paranormal  #supernatural  #metaphysical  #paranormalpodcasts  #darknessradio  #timdennis #kindredspirits #amybruni #adamberry  #chipcoffey  #ghosts  #spirits  #hauntings #hauntedhouses #haunteddolls #demons #deliverances #exorcisms #angels #guardianangels #spiritguides #Psychics #mediums #tarot  #ouija #shadowpeople #discoveryplus #travelchannel

Um refrescante banho no rio, a espera paciente para pescar o almoço e os temores quando à Cobra Grande que desce a correnteza. Estes são alguns aspectos que fazem parte da vida diária dos índios da Amazônia, apresentadas às crianças sob a forma de singelos poemas. * Este episódio faz parte da série "Brasis de Pai para Filha", patrocinada pelo Consulado-Geral do Brasil em Londres. São 20 episódios que celebram a riqueza cultural, a diversidade racial e o patrimônio natural do Brasil no ano do bicentenário da Independência. Texto: Tiago Hakiy Ilustrações: Taísa Borges Editora: Panda Books Edição do episódio: Bruno Allevato ____ O Histórias de Pai Para Filha é um podcast que agrada a pais e filhos, com histórias produzidas, escritas ou adaptadas por mim, um pai coruja que quer ensinar à sua filha o gosto pelas histórias e pela língua portuguesa. Siga meu perfil no Instagram @pablouch e acompanhe o podcast também pelo Youtube (www.youtube.com/historiasdepaiparafilha) --- Send in a voice message: https://anchor.fm/depaiparafilha/message

Hung out with Mae Estes, and talked all about life and our love for music. We talked about the state of Country Music in Nashville and how it's always changing and evolving. Big time fan of this girl and everything she's got going on. Go stream her music wherever you stream! Mae's Insta: https://www.instagram.com/maeestes/ Our Insta: https://www.instagram.com/rcm_podcast/ --- Support this podcast: https://anchor.fm/kyle-corbliss/support

Estes são os nossos Momentos GPS. Momentos que seleccionei especialmente para levares contigo neste final de semana. A sugestão é que os possas utilizar como ponto de partida para uma reflexão e, talvez, reformulação das tuas coordenadas. Nesta viagem da Parentalidade Não-Conjugal e do Divórcio Consciente, recalcular a rota é essencial e desfrutar do caminho também. Neste Momento, eu, Mafalda, a Marcela Almeida e a Mikaela Övén partilhamos o impacto da comunidade/da sociedade na forma como o Divórcio é vivido pelos pais e pelos filhos, como os valores da Parentalidade Consciente podem contribuir para processos de Divórcio mais Conscientes e como, no fundo, todos nós o podemos fazer, ser tivermos a intenção de ser, como diz a Mia, «activistas para um Mundo melhor». Se não ouviste o episódio completo, podes fazê-lo seguindo o link. Porque este foi mesmo só um momento… A Mia fundou a Academia de Parentalidade Consciente e é co-host dos podcasts "Inspiração para Uma Vida Mágica" e "O Podcast da Parentalidade Consciente». É também autora dos livros «Educar com Mindfulness», «Educar com Mindfulness na Adolescência», «Heartfulness» e do «Caderno da Família Feliz».

If you're a country music fan, you're going to love this episode! Nashville recording and touring artist Mae Estes from Hope, AR is coming back home to play some music. She was the 2021 and 2022 Arkansas CMA Female Vocalist of the Year. The first music video of her career was exclusively premiered on CMT and she tours internationally! In this episode, she talks about exciting events happening in southwest Arkansas, what it's like as an independent artist chasing her dreams in the Music City, where she finds her inspiration, and much more! How can you support Mae and her music? Visit HERE. 

No Palácio do Planalto, o ministro Paulo Pimenta da Secretaria de Comunicação Social, conversou com a imprensa sobre a divulgação de dados de quebras de sigilo no cartão corporativo de Bolsonaro. Segundo Pimenta, o governo Jair Bolsonaro (PL) negou mais de 65 mil pedidos via LAI (Lei de Acesso à Informação) alegando sigilo por questões de segurança. O ministro Paulo Pimenta disse que , 2 mil deles ainda estão sendo analisados pela CGU (Controladoria Geral da União), por causa do decreto assinado por Lula no dia da posse, que visa liberar as informações escondidas pelo antigo governo. Na manhã desta quinta (12), a Secretaria Geral do governo Lula (PT) liberou os gastos de Bolsonaro com cartão corporativo, que chegaram a R$ 27,6 milhões entre 2019 e 2022. Segundo Pimenta, estes dados são diferentes das demais quebra de sigilos, como a carteira de vacinação do ex-presidente ou relativos à gestão do ex-ministro Eduardo Pazuello à frente da Saúde. Estes ainda dependem da CGU para ser revelados. "Estas informações que têm sido divulgadas [hoje] foram divulgadas por conta de decisão do Tribunal de Contas [da União]. Isso não tem nada a ver com o decreto [de Lula] que está em vigência. No prazo de 30 dias [a partir de 1º], a CGU vai fazer uma análise de outras informações, de outros documentos, que foram colocados em sigilo e hoje são objetos de análise do novo governo.", disse Paulo Pimenta, ministro da Secretaria de Comunicação Social. . radio..pt.org.br

It's a changing world of consumer research. There's never been more data at our fingertips, but with that comes privacy and ethical concerns. How do you pull out insights that will positively impact your business? It comes down to keeping humans first, what to do about data access we may shortly lose, not overindexing on too narrow an audience, and keeping the consumer a part of the process. As always, some big questions face us in the research world. How much data is needed for us to feel confident we have the right audience? What are the best ways to get cost-effective information from consumers? And how do you frame up the conversation to get the most bang for your buck? We wanted you to learn from a true expert in the consumer research space, so we welcomed on Janelle Estes. She's the Chief Insights Officer of UserTesting, a human insight platform focused on improving customer experience (CX). And as always, if you need help in building your Marketing Smarts, don't hesitate to reach out to us at: ForthRight-People.com. FACEBOOK https://www.facebook.com/forthrightpeople.marketingagency INSTAGRAM https://www.instagram.com/forthrightpeople/ LINKEDIN https://www.linkedin.com/company/forthright-people/ WORKSHEETS https://www.forthright-people.com/worksheets VIRTUAL CONSULTANCY https://www.forthright-people.com/shop

Apesar de números expressivos, que refletem a importância econômica das atividades no agronegócio e, por consequência, para a economia do país como um todo, a pecuária ainda enfrenta desafios que prejudicam a produtividade, impedindo que ela cresça ainda mais. A produtividade tem sido o grande desafio da pecuária de corte e de leite, atividades que movimentam, juntas, mais de US $25 bilhões por ano, somente dentro das fazendas. Estes valores mais que triplicam se considerarmos os segmentos ligados à indústria e à comercialização de carnes e lácteos.E a questão sanitária é um dos mais importantes pontos de atenção, e um dos casos mais relevantes é a incidência de parasitas nos bovinos.As parasitoses causam severos prejuízos à pecuária, muitos deles bem conhecidos dos produtores, como a redução do ganho de peso dos animais e o emagrecimento progressivo, os quais promovem perdas de desempenho e de eficiência reprodutiva.Combatendo os parasitos, há incremento na lucratividade dos sistemas de produção.Quando as verminoses estão associadas à presença de carrapatos e de moscas-dos-chifres, e aí as perdas são ainda mais severas. O produtor acaba não alcançando os resultados produtivos esperados com seu rebanho, mesmo realizando pesados investimentos em genética e nutrição.O programa OPG Multiação tem o objetivo de influenciar o tratamento estratégico de 5 milhões de bovinos até o fim deste ano, impactando mais de 1.100 propriedades em todo Brasil.OPG é a medida utilizada para verificar o índice da presença de vermes gastrointestinais nos bovinos. Taxa acima de 250 ovos por grama de fezes indica que o animal está infectado e que o produtor já está tendo perdas de produtividade.Este prejuízo chega em média a mais 40 quilos por animal ao ano – ou seja, quase 2 arrobas – e podendo ultrapassar os R $800 anuais por bovino, apenas com o impacto das verminoses. Soma-se a isso o baixo aproveitamento do suplemento mineral e das pastagens consumidas pelo animal, refletindo em baixo desempenho. Com esse importante serviço, estamos contribuindo para massificar a identificação dos vermes gastrointestinais das propriedades, problema extremamente relevante, que compromete o ganho de peso na fazenda. Para explorarmos e melhor entendermos estes impactos das verminoses, convidamos Guilherme Moura, médico veterinário, doutor em ciência animal pela Universidade Federal de Minas Gerais (UFMG) e  gerente de serviços técnicos da Vetoquinol Saúde Animal que nos dará formas de melhor contribuirmos para a evolução da produção animal no Brasil. https://linktr.ee/academiadoagrohttps://podfollow.com/academia-do-agro ................Para assinar e ouvir o podcast:Spotify: https://spoti.fi/33WG1dwDeezer: https://bit.ly/2VOuubAApple: https://apple.co/3oyQzaxGoogle: https://bit.ly/3lWvpS7Amazon: https://bit.ly/34xCWReYouTube: https://bit.ly/3mZop7p................Participe da Academia: https://t.me/ADA_AcademiaDoAgro Links Citados no Episódio https://www.vetoquinol.com.br https://www.boehringer-ingelheim.com.br/press-release/parasitas-bovinos-podem-causar-perdas-de-bilhoes ------------------------------------ Perfil do Entrevistado GUILHERME MOURAGuilherme Moura, médico veterinário, doutor em ciência animal pela Universidade Federal de Minas Gerais (UFMG) e gerente de serviços técnicos da Vetoquinol Saúde Animal INTERAJA COM GUILHERME MOURAE-mail: Guilherme.moura@vetoquinol.comSite:  https://www.vetoquinol.com.br INTERAJA COM  ACADEMIA DO AGROLinkedIn: https://www.linkedin.com/in/waldir.franziniInstagram:- www.instagram.com/academiadoagroTwitter: @academiadoagroTelegram: @academiadoagroFacebook: /academiadoagroCelular-Whatsapp: 062 9 9700 7049E-mail: podcast.academiadoagro@gmail.comACOMPANHE A REDE AGROCASThttps://www.redeagrocast.com.br/Somos da Agrocast. A primeira rede de podcasts do agronegócio brasileiro e tem o objetivo de aumentar o consumo da mídia pelo setor, bem como estimular a criação de novos podcasts do agro.Rede Agrocast: @redeagrocastAcademia do Agro: @academiadoagroAgro Resenha: @agroresenhaBendito Agro: @benditoagroBug Bites: @bugbitespodcastCachaça, Prosa & Viola :@cpvpodcastEsalqast: @esalqastMundo Agro Podcast: @mundoagropodcastNotícias do Front: @noticias_do_frontPapo Agro: @papoagropodcastRumen Cast: @rumencast Apoio:W. Franzini - Gestão do Agronegócio ME Ficha Técnica:Produção: Waldir FranziniEdição/masterização - A Fabrica de Podcast - https://www.afabricadepodcast.com.br/Musica: CC BY  - CC BY SAhttp://creativecommons.org/licenses/by/3.0/us/ Se você tem alguma sugestão de pauta, reclamação ou dúvida envie um e-mail para podcast.academiadoagro@gmail.com  | waldir.franzini@gmail.com | Whatsapp: 062 99700-7049

John talks with U.S. Rep. Ron Estes about the struggle for Republicans to elect a Speaker of the House.

Estes são os nossos Momentos GPS. Momentos que seleccionei especialmente para levares contigo neste final de semana. A sugestão é que os possas utilizar como ponto de partida para uma reflexão e, talvez, reformulação das tuas coordenadas. Nesta viagem da Parentalidade Não-Conjugal e do Divórcio Consciente, recalcular a rota é essencial e desfrutar do caminho também. Neste Momento, a Mariana D'Orey partilha a importância tanto da comunidade escolar, como dos vizinhos e amigos, na sua experiência pessoal do divórcio, enquanto filha. Se não ouviste o episódio completo, podes fazê-lo seguindo o link. Porque este foi mesmo só um momento… A Mariana D'Orey é mãe de três, jornalista, apresenta o programa “Filhos & Cadilhos” do Porto Canal, é co-host de “O Podcast da Parentalidade Consciente”, é adepta de slowparenting e sustainable life… Podes seguir a @marianaadorey nas redes sociais, acompanhar o seu programa e o podcast.

2023 begins with some belated gifts, not to mention a plethora of episodes and Inside Track goings-on. This month we'll be talking with Dr. Maranda Trahan and Amanda Ripley about gerontology, Dr. Jamie Hughes-Lika about NDBIs, and ourselves about visual supports (including Rob's favorite research story of 2022). Interested in joining the Winter Book Club on the topic of parenting? How about voting on an ethics topic for February? All that can be yours by supporting us on Patreon (but better do it soon!) Articles for January 2023 Gerontology Revisited w/ Dr. Maranda Trahan + Amanda Ripley Drossel, C. & Trahan, M.A. (2015). Behavioral interventions are first-line treatments for managing changes associated with cognitive decline. The Behavior Therapist, 38, 126-131. Burgio, L.D. & Burgio, K.L. (1986). Behavioral gerontology: Applications of behavioral methods to the problems of older adults. Journal of Applied Behavior Analysis, 19, 321-328. doi: 10.1901/jaba.1986.19-321   Visual Supports (LIVE) Meadan, H. Ostrosky, M.M., Triplett, B., Michna, A., & Fettig, A. (2011). Using visual supports with young children with autism spectrum disorder. Teaching Exceptional Children, 43, 28-35. doi: 10.1177/004005991104399693 Duttlinger, C., Ayres, K.M., Bevill-Davis, A., & Douglas, K.H. (2012). The effects of a picture activity schedule for students with intellectual disability to complete a seqeunce of tasks following verbal directions. Focus on Autism and Other Developmental Disabilities, 28, 32-43. doi: 10.1177/1088357612460572 Bateman, K.J., Wilson, S.E., Gauvreau, A., Matthews, K., Gucwa, M., Therrien, W., Nevill, R., & Mazurek, M. (2022). Visual supports to increase conversation engagmeent for preschoolers with autism spectrum disorder during mealtimes: An initial investigation. Journal of Early Intervention. 1-22. doi: 10.1177/10538151221111762 Fields, C.J. & Demchak, M. (2019). Integrated visual supports in a school-based microenterprise for students with intellectual disabilities. Career Development and Transition for Exceptional Individuals, 42, 128-134. doi: 10.1177/2165143418769611 Naturalistic Developmental Behavioral Intervention w/ Dr. Jamie Hughes-Lika Vivanti, G. & Stahmer, A.C. (2021). Can the Early Start Denver Model be considered ABA practice? Behavior Analysis in Practice, 14, 230-239. doi: 10.1007/s40617-020-00474-3 Rogers, S.J., Yoder, P., Estes, A., Warren, Z., McEachin, J., Munson, J., Rocha, M., Greenson, J., Wallace, L., & Gardner, E. (2021). A multisite randomized controlled tiral comparing the effects of intervention intensity and intervention sytle on outcomes for young children with autism. Journal of the American Academy of Child and Adolescent Psychiatry, 60, 710-722. doi: 10.1016/j.jaac.2020.06.013 Schreibman, L., Dawson, G., Stahmer, A.C., Landa, R., Rogers, S.J., McGee, G.G., Kasar, C., Ingersoll, B., Kaiser, A.P., Bruinsma, Y., McNerney, E., Wetherby, A., & Hadley, A. (2015). Naturalistic developmental behavioral interventions: Empirically validated treatments for autism spectrum disorder. Journal of Autism and Developmental Disorders, 45, 2411-2428. doi: 10.1007/s10803-015-2407-8

Paranormal researcher Heather Moser shares her perspective on investigation etiquette, historical research, and how folklore may influence phenomena! Heather is lead researcher for Small Town Monsters, as well as a contributor to two volumes of the Feminine Macabre. We started off our chat discussing investigation equipment, and whether the accessibility of paranormal investigation may influence how phenomena manifests. It did not take us long to deviate into elaborate discussion on tulpas, egregores, haunted objects, headless ghosts, the Bell Witch, and whether the land itself may be utilizing our own folklore to lure us into assuming the role of researchers and retellers of its own history! ====================== Huge THANK YOU!!! to Heather for pulling through our recording issues, allowing our chat to become an intricate and unintentional application of the Estes method! Follow her on Instagram @paganhistorian Read her blog posts on Shannon LeGro's Weird Writers Blog or on The Caravan, Library of Lore Blog Purchase all volumes of The Feminine Macabre HERE Check out Small Town Monsters at www.smalltownmonsters.com ====================== Send us suggestions and comments to tracingowlspodcast@gmail.com Follow us on Instagram @tracingowls or Twitter @TracingOwls Check our Linktree: linktr.ee/tracingowls Intro sampled from "Something strange lurks in the shadows" by Francisco Sánchez (@fanchisanchez) Sound effects obtained from https://www.zapsplat.com

Did man come from monkeys...FUNNY Sheikh Yusuf Estes...

"All Muslims don`t need to wear Hijaab" ┇FUNNY┇ Sh. Yusuf Estes ┇Smile...itz Sunnah┇

Jesus: Man, Myth or God? | Yusuf Estes

Estes são os nossos Momentos GPS. Momentos que seleccionei especialmente para levares contigo neste final de semana. A sugestão é que os possas utilizar como ponto de partida para uma reflexão e, talvez, reformulação das tuas coordenadas. Nesta viagem da Parentalidade Não-Conjugal e do Divórcio Consciente, recalcular a rota é essencial e desfrutar do caminho também. Neste Momento, a Sandra Matos partilha a sua escolha: errar com o coração, e fala-nos como tantas vezes nos aprisionamos a nós próprios quando queremos corresponder às expectativas dos outros, quando nos mantemos em relações onde já não mora o amor, nem a felicidade e nos divorciamos de nós mesmos. No final, revela a chave para a liberdade… Se não ouviste o episódio completo, podes fazê-lo seguindo o link. Porque este foi mesmo só um momento… A Sandra Matos - @rugas_de_mae – é mãe de 3 filhas, fundadora da Escola Babyoga Portugal e autora do livro «Escuta a tua voz». A Sandra faz palestras, sessões individuais de coaching, certificações de professores de Yoga Infantil, artigos, programas online e Retiros no feminino… um contributo real e pragmático para a mudança de paradigmas na parentalidade, na educação e no desenvolvimento pessoal. Podes seguir o seu trabalho na https://www.sandramatos.net/ ou nas redes sociais @rugas_de_mae

EXPOSING AL-QURAN! Wide Muslim Majority Don't Know It | Shaykh Yusuf Estes

PROPHET PBUH Never Said Anyone To Grow Beard By Shaykh Yusuf Estes

Christian Asked Yusuf Estes Why He Accepted Islam

Halal cigarettes?

Estes são alguns dos últimos audios divulgados pela conta de Pelé no Instagram. Um post promocional de um livro sobre sua carreira, agradecimentos pelo apoio durante o tratamento do câncer no cólon e a celebração de seu 82º aniversário, além de uma lembrança do dia em que marcou seu milésimo gol. Na primeira postagem após a confirmação do falecimento, as contas de Pelé nas redes sociais publicaram a seguinte mensagem: "A inspiração e o amor marcaram a jornada de Rei Pelé, que pacificamente faleceu no dia de hoje. Em sua jornada, Edson encantou todos com sua genialidade no esporte, parou uma guerra, fez obras sociais no mundo inteiro e espalhou o que mais acreditava ser a cura para todos os nossos problemas: o amor. A sua mensagem em vida se transforma em legado para as futuras gerações. Amor, amor e amor, para sempre." Leia mais sobre sua carreira: https://oantagonista.uol.com.br/esportes/pele-morre-em-sao-paulo-aos-82-anos/Cadastre-se para receber nossa newsletter: https://bit.ly/2Gl9AdL​ Foto: Rener Pinheiro/CBF Inscreva-se e receba a newsletter:  https://bit.ly/2Gl9AdL Confira mais notícias em nosso site:  https://www.oantagonista.com​ Acompanhe nossas redes sociais:  https://www.fb.com/oantagonista​ https://www.twitter.com/o_antagonista ​https://www.instagram.com/o_antagonista https://www.tiktok.com/@oantagonista_oficial No Youtube deixe seu like e se inscreva no canal: https://www.youtube.com/c/OAntagonista

Christian Cried & Embraced Islam followed by many others by Shaikh Yusuf Estes

The meaning of the word "Islam" is not "Peace" - Yusuf Estes

The Managing Editor of Texas's 247Sports' site breaks down Washington's opponent on both sides of the ball ahead of the 30th Valero Alamo Bowl, to be played Thursday night in San Antonio. To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices

Story of Yusuf Estes - From darkness to light

Understanding Our Addictions with Dr. Cali Estes: Dr. Cali Estes, Ph.D is a highly sought after Celebrity Addiction Therapist, Life Coach, Recovery Coach and Wellness Guru that blends talk therapy with forward and positive change to assist her clients in unlocking their true potential. She has been featured in books, magazines, radio and television for her work in the addictions and therapy fields. She works with individuals, drug and alcohol treatment teams and addiction professionals looking to advance their knowledge base. She is best known for her Sober on Demand program, where she brings the entire treatment team directly to the client, anywhere in the globe. Dr. Estes has over 25 years' experience working with drug, alcohol and food addictions. Her deep  understanding of drug and alcohol addiction, including the behaviors and ramifications that are associated with it, place her at the top in the field of addiction therapy. Dr. Estes is an interactive,  solution-focused Positive Psychologist and Cognitive Behavioral Therapist. Her unique no-nonsense  approach of cognitive behavioral therapy, positive psychology and life coaching combine to provide the perfect support for an addict. Dr. Estes' background in food addictions and the emotional and physical tolls it takes on one's psyche and physical well-being is highly unique. Dr. Estes is currently serving as a private practitioner working with a broad spectrum of clients, including top executives, celebrities and NFL.NBA athletes. She has been featured on top tier outs such as NBC Universal News, MSN Money, Entrepreneur Magazine, Max Sports and Fitness, among others for her work in Addiction Recovery and has been published in several journals and is the #1 Best Selling author of 3 books. She has also created and founded the largest online addiction and mental health educational institution in the globe, The Addictions Academy that is currently accredited and trained in 28 countries, 40,000 students and offered in 5 languages. Today's Top 3 Takeaways: Mindset and Mental Health Addiction Awareness Lowering Stressors for Work-Life Balance Today's Guest & Resource Links: https://theaddictioncoachonline.com/ https://theaddictionsacademy.com/ LinkedIn - https://www.linkedin.com/in/caliestes/ Facebook - https://www.facebook.com/DrCaliEstesOfficial Twitter -https://twitter.com/TheAddictionsCo https://www.samhsa.gov/ Cali Estes on Dr. Drew: https://drdrew.com/2016/217/ Our Mentioned Influencers: The Dr. Drew Podcast Watch us on YouTube: https://youtu.be/qtuvdO9UHmc Timestamped Show Notes: 00:30 - Introduction 06:15 - In my second book, the seven keys to tap into the wealth inside you. The first chapter is called eat your broccoli. It talks about how you cannot pour from an empty cup, if you're not healthy, how are you going to help other...

Estes são os nossos Momentos GPS. Momentos que seleccionei especialmente para levares contigo neste final de semana. A sugestão é que os possas utilizar como ponto de partida para uma reflexão e, talvez, reformulação das tuas coordenadas. Nesta viagem da Parentalidade Não-Conjugal e do Divórcio Consciente, recalcular a rota é essencial e desfrutar do caminho também. Neste Momento, partilho a história da nossa árvore de Natal. Uma história que começou quando eu e os meus filhos, o meu companheiro e os seus filhos passámos a viver juntos… Também há “guerras” de poderes e de papéis, na tua família? Quais são os vossos medos? Como sossegam os vossos corações? Qual é a vossa estrela?

Gathering around the pubcast to discuss equine nutrition in the performance horse arena are Dr. Joe Pagan, Dr. Laurie Lawrence and Dr. Steve Jackson. Expert in equine nutrition and founder of Kentucky Equine Research (KER), Dr. Pagan led the conversation by explaining the company's history, his academic background and KER's innovative philosophy in looking ahead into equine nutrition. 7:27Also joining in on the conversation was leading equine nutritionist Dr. Jackson who described his leadership at Bluegrass Equine Nutrition and his experience in one of the largest breed industries, the thoroughbreds. 10:28He acknowledged that with his background and horsemanship experience, most of his clients are usually thoroughbred owners or trainers ranging from central Kentucky to Japan. 12:47Dr. Jackson added he believes good horses often come by happenstance, mentioning most folks making feed or giving recommendations read from the same book giving management the upper hand in success. 13:45Innovation and science, the driving force behind equine nutrition success. Dr. Pagan mentioned when he first started, the industry was focused on sweet feed and straightforward programs. He added that it wasn't until he was in graduate school the emphasis switched to the alternative energy source of feeding fat as a performance source. 18:16However, he added that many in the industry are uncovering the consequences of feeding extremely high fat diets. Dr. Pagan then mentioned that current studies are taking place on polyunsaturated fats as a solution to help correct some of the diet concerns. 20:12Professor at the University of Kentucky, Dr. Laurie Lawrence, also joined in on the discussion. She added that from her academic perspective, she believes a lot of nutritional horse practices have been modeled by those of other species. 27:52What are some examples of low, moderate and high-performance horses? Dr. Estes, podcast co-host and Balchem Research Associate, then asked. 28:47Giving a few examples, Dr. Pagan said racehorses are in the high category, while polo ponies would fit into the middle, and recreational horses would fit into the low level. He then added that he and his team are focused on utilizing technology to alert horse owners on their typical riding time and a nutritional program that would work for them. 30:20While many factors fit into the nutritional space, Dr. Lawrence mentioned the importance of selecting long-stem and clean hay for the average horse rather than the suggested green, leafy and fresh hay quality. 31:15Education is a large factor when it comes to accurate equine nutrition, she added. Suggesting the importance of university research, local agents and the potential that an educational pathway can have in this space. 36:20Dr. Jackson mentioned that he believes the industry, in general, does a poor job of educating practitioners on nutritional needs and recommendations. He added the importance of continuing education for practitioners on various forage types, fat requirements and more. 43:29Making sure the body condition is appropriate for the horse type and the condition is necessary, noted Dr. Jackson. He added the importance of communicating with your nutritionist about the horse's GI tract and forage types. 58:57Dr. Lawrence rounded out the conversation by mentioning that as nutritionists, there is a lot of room for growth in educating horse owners, veterinarians and farriers. Additionally, she added that the industry has enough information to solve nearly 80% of the current nutritional concerns in the recreational horse industry. 1:02:42Please subscribe and share with your industry friends to bring more people to join us around the Real Science Exchange virtual pub table.  If you want one of our new Real Science Exchange t-shirts, screenshot your rating, review, or subscription, and email a picture to anh.marketing@balchem.com. Include your size and mailing address, and we'll get a shirt in the mail to you. 

From being over weight to losing 150+ lbs to slowing building it all back in muscle, Ridge Estes is a prime example of hard work and dedication. Ridge is a D1 thrower at Wichita State University and is on course to join the USA Olympic team. He regularly eats 6,000+ calories per day, squats 685lbs x 4, has a max bench of 470lbs all while maintaining a 50 inch box jump vertical and athletic physique. We cover a lot in this episode-- you're going to want to listen to it all. If you enjoyed this episode please share it with a friend. It helps us out a lot. https://podcasts.apple.com/vg/podcast/real-conversations/id1594231832 Ridge's Instagram: https://www.instagram.com/ridgeestes/ Jacob's Instagram: https://www.instagram.com/thejacoboc/ Jon's Instagram: https://www.instagram.com/thejonpete

Nesta quinta-feira, a Polícia Federal realizou uma operação que cumpriu 103 mandados de busca e apreensão contra pessoas ligadas a atos antidemocráticos em todo o País, entre eles os bloqueios de estradas promovidos por apoiadores do presidente Jair Bolsonaro (PL) inconformados com a vitória do ex-presidente Luiz Inácio Lula da Silva (PT) nas urnas.  As ordens foram expedidas pelo ministro Alexandre de Moraes, do Supremo Tribunal Federal. A ofensiva foi aberta três dias após bolsonaristas tentarem invadir a sede da Polícia Federal em Brasília, além de atearem fogo a carros e ônibus na capital federal. Enquanto isso, o Supremo Tribunal Federal (STF) decide a constitucionalidade do orçamento secreto. A presidente, ministra Rosa Weber, defendeu, durante julgamento que contesta o mecanismo, a derrubada das emendas do relator.  Em duro voto, a magistrada apontou 'verdadeiro regime de exceção ao orçamento da União, em burla à transparência e a distribuição isonômica de recursos públicos'. Mas esse não é o único assunto que preocupa o Congresso. Parlamentares querem espaço no novo governo para aprovar a PEC da Transição. O presidente da Câmara, Arthur Lira (PP-AL), negocia alguns ministérios com o futuro presidente Lula para garantir, pelo menos, 150 parlamentares na base do governo. Por falar em novo governo, Lula (PT) tenta retomar relações internacionais que foram ignoradas pelo atual governo. O futuro ministro das Relações Exteriores, Mauro Vieira, afirmou que o presidente eleito pediu para o Brasil retomar relações com a Venezuela. Estes são alguns dos assuntos que guiam o ‘Poder em Pauta', nossa conversa semanal com os repórteres do Estadão que cobrem o dia a dia da política. Participam desta edição Felipe Frazão, de Brasília, e Pedro Venceslau, de São Paulo. O Estadão Notícias está disponível no Spotify, Deezer, Apple Podcasts, Google podcasts, ou no agregador de podcasts de sua preferência. Apresentação: Emanuel Bomfim Produção/Edição: Gustavo Lopes, Jefferson Perleberg e Gabriela Forte. Sonorização/Montagem: Moacir Biasi.See omnystudio.com/listener for privacy information.

Toda criança brasileira, quando aprende a falar português, aprende também um bocado de palavras de origem tupi. Estes poemas divertidos celebram a influência da língua indígena no nosso vocabulário com bom humor! * Este episódio faz parte da série "Brasis de Pai para Filha", patrocinada pelo Consulado-Geral do Brasil em Londres. São 20 episódios que celebram a riqueza cultural, a diversidade racial e o patrimônio natural do Brasil no ano do bicentenário da Independência. Texto e ilustrações: Maté Editora: Brinque-book Edição do episódio: Bruno Allevato ____ O Histórias de Pai Para Filha é um podcast que agrada a pais e filhos, com histórias produzidas, escritas ou adaptadas por mim, um pai coruja que quer ensinar à sua filha o gosto pelas histórias e pela língua portuguesa. Siga meu perfil no Instagram @pablouch e acompanhe o podcast também pelo Youtube (www.youtube.com/historiasdepaiparafilha) --- Send in a voice message: https://anchor.fm/depaiparafilha/message

Today, Krysta, Laura and Dean discuss the Stanley Hotel, it's founder and first owner, the history of the area and finally discuss the hauntings and it's famous guests. Full disclosure, Dean calls Jim Carrey a coward for fleeing room 217, though Laura and Krysta chastise him for it. Krysta lays down some weird facts about steam powered cars and we discuss the Shining and it's many forms. All together, a well put together plot about a different kind of Christmas vacation.

This week, please join author Trisha Singh as she discusses her article "Manganese-Enhanced Magnetic Resonance Imaging in Takotsubo Syndrome." Dr. Carolyn Lam: Welcome to Circulation on the Run, your weekly podcast summary and backstage pass for the journal and its editors. We're your co-hosts. I'm Dr. Carolyn Nam, Associate Editor from the National Heart Center and Duke National University of Singapore. Dr. Greg Hundley: And I'm Dr. Greg Hundley, Associate Editor, director of the Pauley Heart Center at VCU Health in Richmond, Virginia. Carolyn, very interesting feature discussion this week. Many times we hear in magnetic resonance imaging the use of gadolinium contrast. And remember, gadolinium is an extracellular agent. And when we apply it in the heart, we look for infarcts, or areas of the heart that are perhaps dead, or scarred over. This week's feature discusses manganese as a contrast agent and it is an intracellular contrast agent. And very interestingly, it identifies calcium handling, so it's a marker of viability. And these authors are going to apply manganese as well as gadolinium in trying to understand mechanisms behind Takotsubo cardiomyopathy. But before we get to that, how about we grab a cup of coffee and jump into some of the other articles in the issue? Dr. Carolyn Lam: Oh, I'd love to tell you about the other articles. But just have to first say, I loved your description of the feature paper. It's right up your alley and I can't wait to learn more. But my first paper today I want to talk about pulse field ablation. Now, what is that? Pulse field ablation, or PFA, is a unique and novel technique to treat atrial fibrillation. It has a unique safety profile largely related to its preferentially for myocardial tissue ablation. And thus, sparing the esophagus and thus, deemed to have a unique safety profile. Now, a pentaspline catheter was the first such PFA system studied for AF ablation. And in the initial trials the catheter was used for pulmonary vein isolation and left atrial posterior wall ablation. However, following its regulatory approval in Europe, in clinical practice, physicians have ablated both these locations and expanded lesions that could be in closer proximity to the coronary arteries. Now, this is an unstudied important issue since preclinical and maybe some clinical data have raised the potential for coronary arterial spasm. Hence, the investigators led by Dr. Vivek Reddy from Icahn School of Medicine at Mount Sinai and colleagues studied the vasal spastic potential of PFA lesion sets, both remote from and adjacent to coronary arteries. Dr. Greg Hundley: Wow, Carolyn, this is a really interesting question. So what did they find? Dr. Carolyn Lam: In this retrospective analysis of a series of 25 patients undergoing PFA for atrial fibrillation in whom coronary angiography was performed pre, during and post ablation, they found that during pulmonary vein isolation and left atrial posterior wall ablation, coronary spasm did not occur. However, cavotricuspid isthmus ablation provoked severe subtotal vasospasm in five out of five consecutive patients. And this was relieved by in coronary nitroglycerin. ST elevation was not observed. No patient had severe spasm if first pretreated with parenteral nitroglycerin, either intracoronary or intravenous. And so in summary, coronary vasospasm was not provoked during PFA at locations remote from the coronary arteries. But when the energy is delivered adjacent to a coronary artery, like in cavotricuspid isthmus ablation, PFA did provoke subclinical vasospasm. And the phenomenon was attenuated by nitroglycerine administered either post hoc to treat spasm or as prophylaxis. And this is discussed in accompanying editorial, I like it, “Coronary Vasospasm in PFA Primum Non Nocere” by Drs. Estes and Sundeep and Saba. Dr. Greg Hundley: Very nice Carolyn. Very important research in this area using that particular methodology. Well Carolyn, my next study comes to us again from preclinical science. And Carolyn, this study evaluated mechanisms responsible for pulmonary hypertension. So as background, pulmonary hypertension is associated with increased expression of VEGFA and it's receptor VEGFR-2. But whether and how activation of VEGFA signal participates in the pathogenesis of pulmonary hypertension, that's unclear. And so these authors led by Dr. Yangxin Chen from Sun Yat-Sen Memorial Hospital and Sun Yat-Sen University evaluated VEGFA, VEGFR-2 signal activation and VEGFR-2 Y949 dependent vascular leak in lung samples from patients with pulmonary hypertension as well as in mice exposed to hypoxia. Dr. Carolyn Lam: Another one of those excellent translational pieces, isn't it Greg? So what did they find? Dr. Greg Hundley: Right Carolyn. So these authors found that pulmonary hypertension led to excessive pulmonary vascular leak in both patients and hypoxic mice. And this was owing to over activated VEGFA and VEGFR-2 Y949 signaling axis. Abolishing VEGFR-2 Y949 signaling via a specific point mutation was sufficient to prevent pulmonary vascular permeability and inhibit macrophage infiltration and Rac1 activation in smooth muscle cells under hypoxia exposure. This, in turn, led to alleviation of pulmonary hypertension manifestations including muscularization of distal pulmonary arterials, elevation of right ventricular systolic pressure and right ventricular hypertrophy. And so Carolyn, in summary, these results suggest that VEGFA, VEGFR-2 Y949 dependent vascular permeability is an important determinant in the pathogenesis of pulmonary hypertension and might serve as an attractive therapeutic target pathway for this disease. Dr. Carolyn Lam: Aw, thanks Greg for explaining that so well. The next paper talks about transcatheter aortic valve replacement of TAVR, recognizing that it is a well established treatment now for high and intermediate risk patients with severe symptomatic aortic stenosis. However, the question asked here is what makes some, but not all patients improve their left ventricular ejection fraction following TAVR associated after load reduction? Now, hypothesizing that circulating microRNAs may play a role here, the authors led by corresponding authors, Dr. Hosen and Jansen from University of Bonn and their colleagues profiled the differential expression of microRNAs in circulating extracellular vesicles in patients after TAVR. And in particular, the novel role of circulating microRNA 1225p in cardiomyocytes. Dr. Greg Hundley: Oh wow. So Carolyn, important study. So what did they find? Dr. Carolyn Lam: Well, first aortic stenosis increases circulating microRNA 1225p, which correlated with a lack of improvement of the EF in patients after TAVR. Extracellular vesicles harbored microRNA 1225p and facilitated its startling into the cardiomyocytes. Vesicular shuttling of this particular microRNA was regulated by a direct interaction with a multifunctional RNA binding protein called heterogeneous nuclear ribonucleoprotein U in a sequence specific manner. Extracellular vesicles containing the specific microRNA post transcriptionally repressed BCL2 an anti-apoptotic gene, which is central to cell viability and apoptosis. So in summary, Greg, an increase in extracellular vesicle microRNA 1225p in patients with aortic stenosis represents a novel mechanism for the deterioration of cardiac function in patients following TAVR. And pharmacological manipulation of this axis may improve ejection fraction and cardiac function in patients with aortic stenosis by improving the viability of cardiomyocytes, which opens the door to a potential therapeutic approach in patients with limited EF improvement following TAVR. Dr. Greg Hundley: Oh Carolyn, beautiful, beautiful description of that wonderful preclinical science. Well, let's reach into the mail bag and see what else is in the issue. And first, there's a research letter by Professor van Raalte entitled “Kidney Hemodynamic Effects of Angiotensin Receptor Blockades Sodium Glucose Co-transporter 2 Inhibition Alone and in Their Combination: A Crossover Randomized Trial in People with Type 2 Diabetes.” And Carolyn, there's also an In Depth piece from Dr. Marx entitled “GLP1 Receptor Agonist for the Reduction of Atherosclerotic Cardiovascular Risk in Patients with Type 2 Diabetes.” Dr. Carolyn Lam: Very, very nice papers, those two. There's also an exchange of letters between Drs. Hou and Sedej regarding the article, “Fine Tuning Cardiac Insulin Like Growth Factor 1 Receptor Signaling to Promote Health and Longevity.” As well as a Perspective by Dr. Eagle, “Comments on the 2022 Aortic Guidelines: Seeking More Precision in Aortic Care.” Now, let's go onto the feature discussion of all things MRI, shall we? Dr. Greg Hundley: You bet. More on manganese. Welcome listeners to this very interesting feature discussion on December 13th. And we have with us Dr. Trisha Singh from the University of Edinburgh in Edinburgh, Scotland. Welcome, Trisha. This is a fascinating study incorporating manganese cardiovascular magnetic resonance to study some of the mechanistic underpinnings of hypokinesis left ventricular hypokinesis in patients with Takotsubo syndrome. So maybe just describe for us some of the background information that went into the preparation of your study, and what was the hypothesis that you wanted to address? Dr. Trisha Singh: Yes, of course. So we know with patients with Takotsubo syndrome, it predominantly affects middle aged women, patients present with a degree of left ventricular dysfunction, which is transient. And, unfortunately, it can be quite difficult to diagnose because it can phenotypically present very similar to an acute coronary syndrome. We know from previous studies that these patients do have ongoing symptoms despite normalization of their LV function. And actually their outcomes are not as benign as previously thought. In terms of manganese enhanced MRI imaging, we at Edinburgh University have imaged patients with other cardiac conditions such as hypertrophic cardiomyopathy, and dilated cardiomyopathy. And have established that it can be used as a surrogate marker of myocardial calcium uptake and handling. So we were very interested to see whether or not patients with acute Takotsubo syndrome have got a myocardial calcium dysfunction and more importantly whether or not this translates into long-term dysfunction and perhaps could explain their symptoms and worse prognosis in long-term. Dr. Greg Hundley: Trisha, manganese MRI. Now, we hear about gadolinium MRI, how is manganese different? You mentioned it's a nice marker for calcium handling. Is this widely used clinically? What kind of contrast does it provide? Dr. Trisha Singh: So manganese was actually one of the first contrast agents to be used with magnetic resonance imaging. It kind of came about in the 1970s and 1980s. And previous animal models have looked at how it is essentially an intracellular contrast agent. And what I mean by that is manganese is a calcium analog and therefore, in cells where they are viable and there's intact cell function, they will be taken up through a voltage gated calcium channels. So, for example, in the heart. So the theory is that manganese, when you've got normal viability, manganese is taken up into the myocardium via voltage gate calcium channels. And several studies have shown that if you then have disease myocardium, these tissues do not take up the manganese as normal tissue would. And the main difference between manganese and gadolinium is they are both paramagnetic, which is why they're helpful and useful in MRI. But gadolinium, as a compound, is too big and it cannot cross an intact cell membrane and therefore, gadolinium is more extracellular. And as, we know, accumulates in tissues where there is increased edema, or water content. So gadolinium, for all intents and purposes, is incredibly useful contrast agent, certainly what we use predominantly at the moment in clinical practice, but it is extracellular. So the theory behind manganese is that it is an intracellular contrast agent as opposed to gadolinium. And where gadolinium accumulates in disease tissue, manganese accumulates in viable tissue. So they behave almost kind of in contrast to each other. And currently, manganese is not used in clinical practice. I think the only clinical compound contrast agent utilizing manganese was mangafodipir, otherwise known as Teslascan, which I believe came off the market in 2012 and that was predominantly used for imaging liver metastasis. Dr. Greg Hundley: Well Trisha, thank you for clarifying for us the difference between manganese, the intracellular contrast agent, and gadolinium, the extracellular contrast agent, that's so widely used clinically. Well, with that description, can you describe for us now, your study population and your study design? Dr. Trisha Singh: Perfect. So the study population was we aimed to recruit 20 patients with acute Takotsubo syndrome. The diagnosis of Takotsubo syndrome was based on a clinical diagnosis, so all our patients underwent a baseline echocardiography and invasive coronary angiography. Now, for us, the coronary angiography was quite important because we wanted to ensure we ruled out anyone with an acute myocardial infarction, which can often be tricky in this cohort of patients. So after recruiting 20 patients during the acute phase of Takotsubo, they all underwent a baseline gadolinium enhanced MRI scan followed by a manganese enhanced MRI scan. And these were done at least 48 hours a part. And then about three months roughly after the acute index, they were all invited to participate in a second manganese enhanced MRI scan. Dr. Greg Hundley: Very good. So two exams separated longitudinally over time. What were your study results? Dr. Trisha Singh: Our results demonstrated that during the acute phase as one would expect, patients had a degree of left ventricular dysfunction. The majority of our patients had afibrillar Takotsubo, so had afibrillar ballooning with preservation of the basal segments. With this, we also noted that in the areas that were affected by Takotsubo, so kind of the mid ventricular wall and the apex that all patients had significantly elevated native T1 and associated T2 as well. And as we expected there was reduced uptake of manganese and therefore kind of reduced calcium uptake in the myocardium in the area affected by Takotsubo syndrome. Interesting, what we also noticed was that all these patients had significantly elevated LV mass, which has been described in previous Takotsubo papers, certainly by Professor Dawson. And when you measured the left ventricular wall thickness, the LV wall thickness is elevated in the affected and actually not even in the non-affected areas, which I suspect explains why in the acute phase people almost doubles up which kind I guess fit with kind of acute myocardial edema and intense water content. And then, three months later when these patients returned for their follow-up scan, a lot of the acute changes had resolved. So native T2 values had improved and gone back to baseline. Native T1 and post contrast T1 values had remained elevated compared to the control population. And what we found was that manganese uptake, though it had improved, it still remained abnormal and reduced compared to the control population, which is a finding that we weren't expecting to find. Dr. Greg Hundley: Very interesting. So acutely we've got extracellular water there, elevation of myocardial T2, and also impaired manganese uptake. So intracellular abnormalities with calcium handling. Then later, so three months later, we have restoration of myocardial T2 so the extra water content is absent, but we have impaired manganese uptake indicating an abnormality with calcium handling. So how do we put this all together mechanistically? What does this tell us about the pathophysiology of Takotsubo syndrome? Dr. Trisha Singh: For one thing, I think we can say that there is, as described before, there is obviously intense myocardial edema present in patients with acute Takotsubo. And I think the significant elevation in T2 and LV mass kind of all fits together. Actually interestingly, as native T2 improves in their follow-up scans, the LV mass actually all return back to normal baseline. So I think the acute edema does resolve. And as you said, interestingly, despite all of these patients, their LV function completely recover. And despite that their myocardial calcium uptake, or handling remain normal. And I think that's not been demonstrated before. And I think it just points to that there is obviously, still something going on in the myocardium and it's not behaving completely normally despite completely normal kind of gross LV function. And potentially, this might point in the direction of why these patients have ongoing symptoms. So, certainly, from our observational cohort group, about 70% of patients had ongoing symptoms and this was predominantly breathlessness and palpitations. And potentially, might be related to why patients have worse outcomes compared to the general population. Dr. Greg Hundley: Very nice. And Trisha, can you describe, was there a therapeutic intervention between the acute and then the three month later measurements? Were these patients administered any type of medical therapy and were there differences in what those therapies may have been between different patients in your study? Dr. Trisha Singh: So predominantly, most of the patient population that were started on some combination of heart treatment due to the baseline LV dysfunction. And this kind of was a combination of most of them were on Ramipril, a few of them were also on spironolactone or eplerenone. And then, every single one was on furosemide. And interestingly, I mean I appreciate, I think the population group was quite small, so it's very difficult to compare those that were on kind of full heart failure treatment versus those who were just on beta blocker and ramipril therapy. But even in that cohort there was a split of about, I think predominantly, I think 17, 16 patients were on kind just beta blockers and ramipril as opposed to beta blocker, ramipril, spironolactone. And there was no difference kind of in the recovery in manganese uptake in that cohort. But, again, the numbers are quite small, so I think it's difficult to extrapolate any kind of true meaning in that. Of course, we know there's a lack of randomized control trial data looking at how to best treat patients with acute Takotsubo syndrome and certainly, what treatment may prevent these patients from having a recurrence of Takotsubo. And I know some of the TACA registry data has looked at actually despite the fact patients of being on beta blocker, or ramipril therapy, they still go having recurrence of Takotsubo and certainly of our cohort, one of our patients went on having a recurrent episode of Takotsubo within a year of her index event and she was on aspirin, beta blocker, spironolactone as well. Dr. Greg Hundley: Very nice. And then lastly, when you made these measurements looking at the manganese uptake or lack thereof, were these in the regions of myocardium where you mentioned many had apical LV wall motion abnormalities, were they in those regions or did you also measure regions remote to where the wall motion abnormality occurred? Dr. Trisha Singh: Of course. So we took measurements in the affected regions of the heart that kind of demonstrated spironolactone syndrome. And we also took measurements in kind of, so to speak, the remote segments of the heart. Now, for the remote segments of the heart, we could only measure native T1 and post contrast T1 at 30 minutes and to measure manganese uptake well, unfortunately, what we have to do is take a measurement over time, so we'd do every two and a half minutes for 30 minutes after the manganese contrast. So we weren't able to calculate manganese uptake in the remote regions. But what we could do was measure the native T1 in the remote region, and then the post contrast T1 and see how it differed with the region of interest in the affected portion of the heart, so to speak. Dr. Greg Hundley: Very good. Well, Trisha, with this really exciting research and very nice methodology, what do you see as the next study to be performed in patients with Takotsubo? Dr. Trisha Singh: So I think, in terms of manganese enhanced imaging, I think it'd be really interesting to re-scan these patients at one year or at two years. And the question there is whether or not their manganese uptake ever recovers really. I know we previously talked about this and thought about whether or not these patients who go onto developing Takotsubo syndrome might actually have a kind of an underlying cardiomyopathy that puts them at risk of developing Takotsubo with stress. So it'd be interesting to see whether or not actually their calcium uptake ever recovers in the long-term, or whether actually they have more of a chronic heart failure type like picture. And I think another area of interest would be to see potentially using manganese imaging as a noninvasive measure of kind of myocardial calcium activity and to see whether or there's any changes with therapy over the course of months to years or so. Dr. Greg Hundley: Very nice. Well listeners, we want to thank Dr. Trisha Singh from University of Edinburgh in Edinburgh, Scotland for bringing us this really interesting article in patients with Takotsubo syndrome demonstrating that there is a marked perturbation of myocardial manganese uptake, which is most evident in the acute phase of Takotsubo presentation, but also persists for at least three months despite apparent restoration of normal left ventricular ejection fraction and resolution of myocardial edema. All of this suggesting that abnormal myocardial calcium handling may be implicated in the pathophysiology of Takotsubo syndrome. Well, on behalf of Carolyn and myself, we want to wish you a great week. And we will catch you next week on the run. This program is copyright of the American Heart Association 2022. The opinions expressed by speakers in this podcast are their own and not necessarily those of the editors or of the American Heart Association. For more, please visit ajjournals.org.

O presidente eleito Luiz Inácio Lula da Silva (PT) deverá anunciar alguns futuros ministros nesta sexta-feira. A expectativa é que, entre os anunciados, estejam os ministros da Fazenda, Fernando Haddad (PT), da Defesa, José Múcio Monteiro, e da Justiça, Flávio Dino (PSB). O novo governo, ainda na sua fase de transição, já conseguiu sua primeira vitória no Congresso Nacional. Os senadores aprovaram em duas votações a chamada PEC da Transição, que abre um espaço fora do teto de gastos de R$ 145 bilhões, mais R$ 23 bilhões para recompor o orçamento deste ano. No entanto, a fase mais difícil começa agora, quando o texto vai para a Câmara dos Deputados, e pode ser modificado, ou até rejeitado. A tendência é que Lula consiga o número de parlamentares para a aprovação. Mas os deputados têm condicionado essa aprovação a um outro tema: orçamento secreto. Nesta semana, começou no Supremo Tribunal Federal (STF), o julgamento sobre a constitucionalidade da medida. Em um entendimento anterior, os ministros já suspenderam o instrumento pela falta de transparência. Os parlamentares se defendem e dizem que já tomaram medidas para tornar o orçamento menos secreto. A agitação acontece também com países vizinhos. No Peru, após uma tentativa fracassada de destituir a Câmara dos Deputados, o presidente Pedro Castillo foi deposto e preso. O líder peruano tentava se salvar de um processo de impeachment por parte dos parlamentares.  Estes são alguns dos assuntos que guiam o ‘Poder em Pauta', nossa conversa semanal com os repórteres do Estadão que cobrem o dia a dia da política. Participam desta edição Felipe Frazão, de Brasília, e Pedro Venceslau, de São Paulo. O Estadão Notícias está disponível no Spotify, Deezer, Apple Podcasts, Google podcasts, ou no agregador de podcasts de sua preferência. Apresentação: Emanuel Bomfim Produção/Edição: Gustavo Lopes, Jefferson Perleberg e Gabriela Forte. Sonorização/Montagem: Moacir Biasi.See omnystudio.com/listener for privacy information.

Gentry Estes joins the show to discuss all things Titans

Um nasceu nos anos 70 do século XIX, o outro nos anos 70 do século XX. Ambos estão na ordem dia. Eis as breves histórias da Roménia e do QatarSee omnystudio.com/listener for privacy information.

In a continuation of our series looking at the future of Estes Park, we dive into the future of fire protection in an in-depth interview with Estes Valley Fire Protection District Fire Chief (EVFPD) David Wolf. There is also an accompanying video tour of the current EVFPD Fire station that you can watch by following the link below. The interview with Chief Wolf in the audio podcast starts at about seven and a half minutes. In the interview, we discuss the possible challenges that the EVFPD may face in the next five to ten years and what might be some of the ways we move forward as a community to meet those challenges. Chief Wolf also breaks down in plain language how funding for the fire district works. Here is the previous article I wrote about the public input that the EVFPD has been asking for public input on.Today's post is sponsored by: This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.coloradoswitchblade.com/subscribe

Sports columnist for @Tennessean, @Gentry_Estes joins the show after returning from Philadelphia to recap the #Titans game vs the Eagles!

The Titans (7-4) came up short against the Bengals again. However, the team is gearing up for a matchup against former Titan A.J. Brown and his Eagles (10-1). The Tennessean's Gentry Estes previews the game and sets the table for the rest of the season. Todd Downing comes up short in his First Day Out. Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode, Ghost Joe interviews Bronxville Paranormal Members, Al Santariga and Bryan Bowden. Edgegrave Dave gives his review on the movie "Smile", and Chris Whitehouse talks about the Estes Method. The Bronxville Paranormal SocietyChris Whitehouse BookInto The DarknessParanoi Radio PodcastIf You Have A Paranormal Experience You'd Like To Share or If You'd Like To Be A Guest On The Show, Please Call (845)600-0744 and leave me a Voicemail! You Can Also Email Me At GhostJoeNY@gmail.comIf You Like The Podcast, Please Leave Me A Review on Apple Podcasts!Chris WhitehouseWhitehouse Investigations YouTubeTalking ParanormalWhitehouse Investigations FacebookWhitehouse Investigations IGThe Warped Reality PodcastOfficial WebsiteFacebook GroupInstagramTikTok

In this episode I read from the classic Women Who Run With The Wolves by Clarissa Pinkola Estes. She tells us about the 'wild woman', the wise and ageless presence in the female psyche that gives women their creativity, energy and power. For centuries, the 'wild woman' has been repressed by a male-orientated value system which trivialises women's emotions. Using a combination of time-honoured stories and contemporary casework, Estes reveals that the 'wild woman' in us is innately healthy, passionate and wise.   I first discovered this book a couple of years ago when Bandana Tewari recommended it on the show. Recently I came back to it, and I want to share the afterword with you in this episode, where we explore the concept - story is medicine.   Discover show notes, our library and more on www.goingconscious.com.   Connect with Nikki:Instagram & LinkedIn @nikkitrott www.consciousaccelerator.com

 Drew Taylor starts off this week's show by looking back on the “Art of DuckTales” panel he just hosted at Gallery Nucleus. Then Drew & Jim Hill look back on the life & career of a Disney Legend Learn more about your ad choices. Visit megaphone.fm/adchoices