Podcasts about personal genome project

The Mindspan Elite live long lives and maintain healthy cognition. On this episode, Drs. Mike and Crystal explore the role of diet and lifestyle factors with Preston Estep III, PhD, a geneticist and the Director of Gerontology at the Personal Genome Project at Harvard Medical School.

In academia, most scientists publish their ideas and stop there. But if we want our breakthroughs to benefit society, we have to take it a step further.  So, what does it look like to commercialize scientific research? What mindset do academics need to work at the intersection of science and industry? Ben Lamm has a career of building successful deep tech businesses, and George Church has a career of commercializing academic science.  Together, they are the cofounders of Colossal, a breakthrough bioscience and genetic engineering company that is pioneering animal de-extinction technology to restore lost ecosystems for a healthier planet.  On this episode of Boost VC, Ben and George join us to explain how bringing back the woolly mammoth addresses climate change and explore their approach to the ethical concerns around de-extinction. They discuss the benefits of Colossal technology beyond Arctic rewilding, describing how their work helps endangered animals and promotes conservation. Listen in for Ben and George's insight on commercializing science and learn how to get comfortable enough with risk to turn academic ideas into industry. Topics Covered How George defines sciencePredict and create new options for humanityGoal to build better world Why Ben & George are bringing back the woolly mammothRestore previous ratio of grass to treesSequester carbon at rate only possible in Arctic How Ben & George approach the ethical concerns re: de-extinctionBelieve in radical transparencyLearn from negative feedback, people who question Why George works at the intersection of academia and industryLikes to work with curious young peopleExposure to diversity of ideas Why Colossal needs government collaboration and supportSeveral governments, Indigenous groups in ArcticClimate change, biodiversity and species preservation How woolly mammoths promote carbon removalKnock down trees so more grass can growCold, Arctic grasslands sequester carbon particularly well The benefits of Colossal technology beyond Arctic rewildingEradicate EHV virus in elephantsPromote species conservation How Ben & George think about commercializing scienceGo beyond publication to help societyFeedback from investors and academia What makes Ben & George's partnership workGeorge's lab provides idea from academic studyBen figures out product-market fit and funding George's advice to academics on commercializing productsCan't be afraid of failureCan come back from bankruptcy How Ben & George think about taking big risksBen believed grandmother saying he could do anythingAcademic failures taught George he would survive The impact Ben & George hope to make with ColossalEx utero development, species preservationThousands of Arctic elephants to sequester carbonAdvancements in reading and writing of genomes How Ben & George define successBenefit society, facilitate survival of speciesCreate things that are additive Connect with George Church & Ben Lamm Colossal https://colossal.comColossal on Twitter https://twitter.com/ItIsColossalColossal on Facebook https://www.facebook.com/itiscolossal/Colossal on Instagram https://www.instagram.com/itiscolossal/George on Twitter https://twitter.com/geochurchBen on Twitter https://twitter.com/federallamm Resources Citizen Science https://www.citizenscience.gov/#Personal Genome Project https://www.personalgenomes.org/How to Grow (Almost) Anything https://www.media.mit.edu/courses/htgaa/DIYbio https://diybio.org/Church Lab https://arep.med.harvard.edu/Hypergiant https://www.hypergiant.com/Pleistocene Park https://pleistocenepark.ru/Chris Mason Author Talk https://mitpress.mit.edu/blog/author-talk-the-next-500-years-by-christopher-e-mason/Prehistoric Planet https://tv.apple.com/us/show/prehistoric-planet/umc.cmc.4lh4bmztauvkooqz400akxav Connect with Boost VCBoost VC Website https://www.boost.vc/Boost VC on Facebook https://www.facebook.com/boostvc/Boost VC on Twitter https://twitter.com/BoostVCBoost VC on Instagram https://www.instagram.com/boost_vc/

In this episode, Dr. George Church and I talked about genome sequencing, NFT and blockchain in the health and biotech industry, and Personal Genome Project. ----------------------------------- Thanks to the partners: Newsly: https://newsly.mepromo code: EARLYMORNING. Anchor https://anchor.fm Libysn https://libsyn.compromo code: DG Hardsnake Energy https://www.instagram.com/hardsnakenrgy spikeview https://www.spikeview.comhttps://www.instagram.com/spikeview ---------------------------------------------------------------------------------- Listen on: Podcast website: https://anchor.fm/diamondgoat Spotify: https://open.spotify.com/show/0EuhA6WyuerHtVAqcFrFeO Google Podcast: https://www.google.com/podcasts?feed=aHR0cHM6Ly9hbmNob3IuZm0vcy80NzE4MzM5MC9wb2RjYXN0L3Jzcw== RadioPublic: https://radiopublic.com/dg-earlymorning-show-WoML4r Breaker: https://www.breaker.audio/dg-early-morning-show Podcast YT channel clips: https://www.youtube.com/channel/UCPZdwPiE-Rb7yv0qQ_7Nqpw Reason: https://reason.fm/podcast/dg-earlymorning-show Apple Podcast: https://podcasts.apple.com/us/podcast/dg-early-morning-show/id1575451533 Amazon Music: https://music.amazon.com/podcasts/f050b86c-1dad-4bc3-b12f-6aa5fa62438c -------------------------------------- Check out my other stuff: Instagram: @itzdiamondgoat Twitter: https://twitter.com/lildiamondgoat Main YT channel: youtube.com/diamondgoat Tiktok: @lildiamondgoat Soundcloud: @Lil Diamondgoat Spotify: @Lil Diamondgoat Merch store: https://diamondgoat.creator-spring.com --- Support this podcast: https://podcasters.spotify.com/pod/show/diamondgoat/support

Diet and brain health The Mindspan Elite live long lives and maintain healthy cognition. On this episode, Drs. Mike and Crystal explore the role of diet and lifestyle factors with Preston Estep III, PhD, a geneticist and the Director of Gerontology at the Personal Genome Project at Harvard Medical School.

Esther Dyson is the executive founder of Wellville, a 10-year nonprofit project dedicated to demonstrating the value of long-term investment in health and equity. The benefits accrue over time and not always to the investors directly, but overall human bodies and minds are the key to the collective future. Wellville wants to show what it looks like when humans act on that fact. Wellville works in five small communities (Clatsop County, OR; Lake COunty, CA; Muskegon County, MI; North Hartford, CT; and Spartanburg, SC), advising local leaders on scaling local initiatives in areas such as early childhood development, diabetes/obesity reduction, mental health support/trauma-informed care. It advocates a data-rich approach with learning and accountability along the way. Esther spends the other 50% of her time exploring new space, health and IT start-ups and technologies, writing about them and actively (and with full disclosure) investing in some of them. She sits on the boards of BAMF Health, Element 3 Health, PressReader, SWVL and Yandex, as well as nonprofits Charity Navigator, ExpandED Schools, Long Now Foundation and The Commons Project.  Her past seats include 23andMe, Evernote, WPP Group, XCOR Aerospace and the Personal Genome Project.

In this video Professor Church talks about his work on his project to recreate a mammoth in the Siberian Arctic. He also talks about the latest work that his lab is working on. George Church is the Robert Winthrop Professor of Genetics at Harvard Medical School, a Professor of Health Sciences and Technology at Harvard and MIT. Professor Church helped initiate the Human Genome Project in 1984 and the Personal Genome Project in 2005. He is widely recognized for his innovative contributions to genomic science and his many pioneering contributions to chemistry and biomedicine. He has co-authored 580 paper, 143 patent publications & the book "Regenesis". If you would like to support our channel, we'd love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan

In this video Professor Church talks about why everyone should get their complete genome sequenced and how we genetic engineering has created organisms which are immune to all viruses, and how potentially this technology could be used for humans. Nebula Genomics - full genome sequencing company started by Professor Church. https://nebula.org/whole-genome-sequencing-dna-test/ George Church is the Robert Winthrop Professor of Genetics at Harvard Medical School, a Professor of Health Sciences and Technology at Harvard and MIT. Professor Church helped initiate the Human Genome Project in 1984 and the Personal Genome Project in 2005. He is widely recognized for his innovative contributions to genomic science and his many pioneering contributions to chemistry and biomedicine. He has co-authored 580 paper, 143 patent publications & the book "Regenesis". If you would like to support our channel, we'd love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan

In this video Professor Church talks about the latest updates in xenotransplantation technology and how they are getting close to clinical trials with the latest Pig 3.0 that has been built with the gene technologies from his lab. He also talks about universal chimeric antigen receptors (CAR) T-Cells for stem cell transplantation. George Church is the Robert Winthrop Professor of Genetics at Harvard Medical School, a Professor of Health Sciences and Technology at Harvard and MIT. Professor Church helped initiate the Human Genome Project in 1984 and the Personal Genome Project in 2005. He is widely recognized for his innovative contributions to genomic science and his many pioneering contributions to chemistry and biomedicine. He has co-authored 580 paper, 143 patent publications & the book "Regenesis". If you would like to support our channel, we'd love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan

In this video Professor Church talks about the latest techniques for building AAVs and using them to delivery gene therapies. George Church is the Robert Winthrop Professor of Genetics at Harvard Medical School, a Professor of Health Sciences and Technology at Harvard and MIT. Professor Church helped initiate the Human Genome Project in 1984 and the Personal Genome Project in 2005. He is widely recognized for his innovative contributions to genomic science and his many pioneering contributions to chemistry and biomedicine. He has co-authored 580 paper, 143 patent publications & the book "Regenesis". If you would like to support our channel, we'd love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan

In this video Professor Church talks how he is using gene therapy to target aging and the benefits of gene therapy when compared to using small molecules. He talks about the study where his lab used a small number of gene therapies to target five or more diseases of aging and the follow up they are now doing. George Church is the Robert Winthrop Professor of Genetics at Harvard Medical School, a Professor of Health Sciences and Technology at Harvard and MIT. Professor Church helped initiate the Human Genome Project in 1984 and the Personal Genome Project in 2005. He is widely recognized for his innovative contributions to genomic science and his many pioneering contributions to chemistry and biomedicine. He has co-authored 580 paper, 143 patent publications & the book "Regenesis". If you would like to support our channel, we'd love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan

In this video Professor Church talks about his theory of aging and touches on his ideas on the future of aging. George Church is the Robert Winthrop Professor of Genetics at Harvard Medical School, a Professor of Health Sciences and Technology at Harvard and MIT. Professor Church helped initiate the Human Genome Project in 1984 and the Personal Genome Project in 2005. He is widely recognized for his innovative contributions to genomic science and his many pioneering contributions to chemistry and biomedicine. He has co-authored 580 paper, 143 patent publications & the book "Regenesis". If you would like to support our channel, we'd love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan

George leads Synthetic Biology at the Wyss Institute, where he oversees the directed evolution of molecules, polymers, and whole genomes to create new tools with applications in regenerative medicine and bio-production of chemicals. Among his recent work at the Wyss is development of a technology for synthesizing whole genes, and engineering whole genomes, far faster, more accurate, and less costly than current methods. George is widely recognized for his innovative contributions to genomic science and his many pioneering contributions to chemistry and biomedicine. In 1984, he developed the first direct genomic sequencing method, which resulted in the first genome sequence (the human pathogen, H. pylori). He helped initiate the Human Genome Project in 1984 and the Personal Genome Project in 2005. George invented the broadly applied concepts of molecular multiplexing and tags, homologous recombination methods, and array DNA synthesizers. His many innovations have been the basis for a number of companies including Editas (Gene therapy); Gen9bio (Synthetic DNA); and Veritas Genetics (full human genome sequencing).

George leads Synthetic Biology at the Wyss Institute, where he oversees the directed evolution of molecules, polymers, and whole genomes to create new tools with applications in regenerative medicine and bio-production of chemicals. Among his recent work at the Wyss is development of a technology for synthesizing whole genes, and engineering whole genomes, far faster, more accurate, and less costly than current methods. George is widely recognized for his innovative contributions to genomic science and his many pioneering contributions to chemistry and biomedicine. In 1984, he developed the first direct genomic sequencing method, which resulted in the first genome sequence (the human pathogen, H. pylori). He helped initiate the Human Genome Project in 1984 and the Personal Genome Project in 2005. George invented the broadly applied concepts of molecular multiplexing and tags, homologous recombination methods, and array DNA synthesizers. His many innovations have been the basis for a number of companies including Editas (Gene therapy); Gen9bio (Synthetic DNA); and Veritas Genetics (full human genome sequencing). George is Professor of Genetics at Harvard Medical School and Professor of Health Sciences and Technology at Harvard and the Massachusetts Institute of Technology (MIT). He is Director of the U.S. Department of Energy Technology Center and Director of the National Institutes of Health Center of Excellence in Genomic Science. He has received numerous awards including the 2011 Bower Award and Prize for Achievement in Science from the Franklin Institute and election to the National Academy of Sciences and Engineering. Thank you for listening! BIOS (@BIOS_Community) unites a community of Life Science innovators dedicated to driving patient impact. Alix Ventures (@AlixVentures) is a San Francisco based venture capital firm supporting early stage Life Science startups engineering biology to create radical advances in human health. Music: Danger Storm by Kevin MacLeod (link & license)

George Church is Robert Winthrop Professor of Genetics at Harvard Medical School and Professor of Health Sciences and Technology at Harvard and MIT. He is known as the father of synthetic biology and the CRISPR-CAS9 gene editing technology, and he is widely recognized as one of the most important geneticists of our age. In 1984, he developed the first direct genomic sequencing method, which resulted in the first genome sequence. He helped initiate the Human Genome Project in 1984 and the Personal Genome Project in 2005. He leads his own lab in Harvard and is also affiliated with the Broad Institute, the Wyss Institute, and a wide number of private companies that were spun off from his innovations. In this interview, Tiger asks Prof. Church about his time as a graduate student and postdoc, how Harvard took a chance on him for many times during his early research career, his experience starting the Human Genome Project and its wide-ranging impacts, his critical contribution to the CRISPR gene editing technology, the ethical and policy impacts of genome technology, and the urgent problems left unsolved in the field. The Human Genome Project began in 1990 and cost $3 billion dollars in federal funding. By 2004, the total stock market value of the genomics sector was $28 billion dollars. The project laid important groundwork for the genomic and biotechnology revolution that later transpired, and is a wonderful example of public-private partnership that is what this country needs today. What was the exact process like to sequence the first genome? What has it produced since, both scientifically and socially? Was the idea that we could sequence everyone in the world perceived as wild or immature? Meanwhile, the Personal Genome Project that Prof. Church founded in 2005 pioneered a new form of genomics research. The main goal of the project is to allow scientists to connect human genetic information (human DNA sequence, gene expression, associated microbial sequence data, etc) with human trait information (medical information, biospecimens and physical traits) and environmental exposures. How is it different from the Human Genome Project? Prof. Church compares the turning point of genome sequencing with the Internet around 1994, when suddenly everyone started using it. They have already helped bring down the cost of sequencing by 10-million fold. Similar to how Silicon Valley helped the Internet revolution by providing all kinds of softwares, it may be an adequate analogy to say that the HGP has provided the infrastructure like the Internet did, and perhaps the next steps would be additional business models and applications around genome sequencing that would further bring down the cost and make the benefits more widely available to everyone. The cost of reading and interpreting a genome has been shrinking exponentially. As the cost of this technology continues to decrease, what new possibilities will emerge? CRISPR is a way of finding a specific bit of DNA inside a cell. CRISPR-CAS9 is a system biologically found in bacteria; it’s their version of a viral defense mechanism. When viral vectors inject DNA into the bacteria's genetic material, the CRISPR-CAS9 system finds it and switches it out with high precision. It allows us to not only delete certain info, but also precisely add in new sequences in specific locations. Prof. Church explains to us how CRISPR works and his critical contributions to the technology at its infancy. Lastly, Prof. Church speaks to the moral-ethical concerns related to the CRISPR technology and synthetic biology at large. While the concept of gene modification is becoming an increasingly controversial topic, Prof. Church believes that not only is it a net positive to our world, our regulations should focus more on mitigating its impacts in a thoughtful manner, rather than trying to suffocate innovation altogether. “A politician trying to ban iPhones wouldn’t survive very long in office,” he joked.

James W. Clement is a lawyer and entrepreneur turned research scientist who has devoted the last two decades to understanding the science of life extension. He is best known for his Supercentenarian Research Study, which he started in 2010 with Professor George M. Church of Harvard Medical School and has received international press coverage. Through worldwide scientific collaborations and in his own laboratory, James focuses on advancing cutting-edge biomedical discoveries. He is the founder of the nonprofit Betterhumans biomedical research organization. Led by a collection of high-profile researchers, the organization focuses on bringing cutting edge scientific discoveries from the lab to the clinic. Clement was the 12th person in the world to have his whole genome sequenced and is Personal Genome Project participant #145   Time Stamps: 10:10 Start of podcast  10:50 What type of research is James doing and how does it relate to aging? 12:55 Compression of morbidity.  23:50 Feedlot meat and processed foods (23:50-24:35) 25:50 Super centenarian studies. 28:25 Observations on what super centenarians have in common. 31:40 Laron Dwarfs and IGF1 (22:00-22:45) 33:30 Should we over stimulate IGF1? 37:10 Measuring IGF1 39:40 Blue Zones and centenarian diets 42:50 Intermittent Hypoxia  46:40 Over fasting, finding a good balance. 51:40 Environmental hormesis  52:50 Okinawans  55:40 Confounding variables. 1:00:25 mTor/ketosis and glycogen depletion in the liver.  1:03:40 Animal based diets and intermittent ketosis. 1:06:10 James' thoughts on the carnivore diet. 1:10:55 Lack of nutrients in a plant based diet. 1:12:30 Benefits of prolonged ketosis in morbidly obese. 1:16:10 Protein sparing modified fast benefits. 1:20:10 Calorie restricted pure vegan diet. 1:22:00 Dexa scan. 1:25:50 James's insulin levels. 1:27:40 AGEs (advanced glycation end products) 1:34:10 Stress and glucose levels. 1:38:50 Does too much protein harm the kidneys? 1:45:10 Protein cycling. 1:46:34 Occasional long term fasting benefits. 1:47:35 Loma Linda sperm quality. 1:49:40 Carnivore diet for longevity. 1:52:20 Issues with studies comparing meat eaters vs. non meat eaters. 1:54:00 The most radical thing James has done recently. Ancestral Supplements https://ancestralsupplements.com/   Code SALADINOMD on the shopify site to receive 10% off.   Use the code CARNIVOREMD at www.whiteoakpastures.com all month for 10% off your order!   JOOVV: www.joovv.com/paul INSIDER: carnivoremd.com   My contact information:   Book: www.thecarnivorecodebook.com   PATREON: https://www.patreon.com/paulsaladinomd   SOCIAL MEDIA  Instagram: @carnivoremd Website: carnivoremd.com Twitter:@carnivoremd  Facebook: Paul Saladino MD email: drpaul@carnivoremd.com

George Church @geochurch) is a professor of genetics at Harvard & MIT, director of the Personal Genome Project, co-author of 509 papers, 143 patent publications and developed methods used for the first genome sequence (1994) & million-fold cost reductions since.It is NO exaggeration to say George's innovations have contributed to nearly all “next generation” DNA sequencing methods and companies; plus his lab's work on chip-DNA-synthesis, gene editing, and stem cell engineering resulted in founding additional application-based companies spanning fields of medical diagnostics and synthetic biology/therapeutics (all of which has led to the creation of over 14 biotech companies he's helped co-foundTo listen to the entire episode, visit: https://disruptors.fm/105-george-church-on-synthetic-biology-climate-change-and-the-superhuman-genome-project/

George Church @geochurch) is a professor of genetics at Harvard & MIT, director of the Personal Genome Project, co-author of 509 papers, 143 patent publications and developed methods used for the first genome sequence (1994) & million-fold cost reductions since. It is NO exaggeration to say George's innovations have contributed to nearly all “next generation” DNA sequencing methods... The post George Church on Synthetic Biology, Climate Change and the SUPERHUMAN Genome Project appeared first on The Syndicate.

George Church @geochurch) is a professor of genetics at Harvard & MIT, director of the Personal Genome Project, co-author of 509 papers, 143 patent publications and developed methods used for the first genome sequence (1994) & million-fold cost reductions since.It is NO exaggeration to say George's innovations have contributed to nearly all "next generation" DNA sequencing methods and companies; plus his lab's work on chip-DNA-synthesis, gene editing, and stem cell engineering resulted in founding additional application-based companies spanning fields of medical diagnostics and synthetic biology/therapeutics (all of which has led to the creation of over 14 biotech companies he's helped co-foundGeorge is the director of the IARPA BRAIN Project and NIH Center for Excellence in Genomic Science and his many honors include election to NAS and NAE and Franklin Bower Laureate for Achievement in Science.George is the author of Regenesis: How Synthetic Biology Will Reinvent Nature and Ourselves and now spends his free time trying to revive the Wholly Mammoth to combat climate change and save the world while remaining the foremost pioneer in the future of synthetic biology and genetic engineering.You can listen right here on iTunesIn today's episode we discuss:* The beginnings of the Human Genome Project and why in a lot of ways George thinks it was a waste of money* The future of genome sequencing and writing and where it's headed* Why George isn't hugely worried about genetic engineering leading to greater inequality* What scares George most in a world of synthetic biology* Why the best solutions to climate change are inevitably bio-based* How George's team is working to revive mammoths to combat climate change* The importance of being guinea pig number one* Why we should be inspired but not limited by nature* The real risk of bioterrorism* How to get benefits from your DNA without exposing your results* The importance of gene editing on getting humanity to space Make a Tax-Deductible Donation to Support The DisruptorsMake a Tax-Deductible Donation to Support The DisruptorsThe Disruptors is supported by the generosity of its readers and listeners. If you find our work valuable, please consider supporting us on Patreon, via Paypal or with DonorBox powered by Stripe.Donate

As a participant of the Personal Genome Project (PGP), which was initiated in 2005 at Harvard Medical School, James Turner has donated a significant amount of information to the project, including an extensive personal health survey, 20 years' worth of notes pertaining to doctor visits, lab tests, treatments, etc., and MRI images. Once submitted to the PGP, a participant's information becomes available to any all researchers for the purposes of driving genetic research. The program has two main goals: to perform whole genome sequencing on as many samples as possible, and to correlate the genetic information obtained with phenotypic data.   As a descendent of the PGP, the Open Humans Foundation takes a slightly different approach to the same idea; it allows participants to choose whether they want their data to be available to everyone or only select researchers, works to facilitate the transfer of information from personal devices to biological data banks, and makes use of data inspired by the Quantified Self Movement (e.g. Fitbit/Apple Watch, diet data). Turner now serves as the treasurer and chairman of this foundation, and he joins the podcast to provide unique insight on the world of genomic data and biological research driven by the people. Press play to hear the full conversation, and visit https://www.personalgenomes.org/us and http://openhumansfoundation.org/ to learn more.

George Church, professor at Harvard & MIT, co-author of 480 papers, 130 patent publications & one book "Regenesis", originally published in 2012. His contributions have enabled nearly all advancements in “next generation” DNA sequencing methods, he’s cofounded over 20 companies and he was listed as one of TIME’s 100 most influential people of 2017. Also considered the father of synthetic biology. George M. Church - http://arep.med.harvard.edu/gmc/ Nebula Genomics - https://www.nebulagenomics.io/ Veritas Genetics - https://www.veritasgenetics.com/ Show Notes • Nebula Genomics origins and Veritas Genetics traction • Genotyping vs. Medical grade whole genome sequencing – prices, value, and utility • Data ownership of personal genomes • Personal Genome Project is an open source/open access collaboration to share genomic and phenotypic information with researchers • 3 Axes: How close to useful medical genome (technically); who controls it (self or corporate); how useful on a day-to-day basis (understandability and interactivity). • Genome sequencing technology adoption and Seat-belts • What scientific and social problems are you most concerned or obsessed with today? • Aging Reversal • Human life extension limitations and perceptions • How Genome sequencing is like the internet back in the late 1980s. • Genome editing risks and biohacking ethics • Equitable distribution of gene editing technology among all the people require lower cost • What’s more important- Information Systems R&D or microbiology wet-lab experiments? How dependent are they on each other? • How did you first hear about blockchain technology? • Personal Genetics Education Project - PGed.org • Cambrian explosion of blockchains • Exploring possibilities of genomic research • What is the basis of consciousness? • George’s favorite scientists Quick Quote: Decoding the human genome sequence is the most significant undertaking that we have mounted so far in an organized way in all of science. I believe that reading our blueprints, cataloguing our own instruction book, will be judged by history as more significant than even splitting the atom or going to the moon. -Francis S. Collins [Director of the National Institute of Health (NIH)] News Corner 23andMe announces $300M deal for your DNA with giant drug company GSK - https://www.digitaltrends.com/cool-tech/23andme-gsk-drugs/

GEORGE CHURCH is professor of genetics at Harvard Medical School, director of the Personal Genome Project, and co-author (with Ed Regis) of Regenesis. The Conversation: https://www.edge.org/conversation/george_church-church-speaks

Genetic testing technology has advanced rapidly and it is becoming more affordable to perform whole genome sequencing. Whole genome sequencing can reveal heritable conditions and predispositions to disease. In this interview, Professor Steve Scherer discusses the findings from the initial cohort of 56 Canadian volunteers who had their whole genome sequenced for the Personal Genome Project Canada. The results, published in the Canadian Medical Association Journal, represent the culmination of 10 years of work by researchers. The project is ongoing. Prof. Scherer is the lead genome scientist at The Centre for Applied Genomics at the Hospital for Sick Children and the McLaughlin Centre at the University of Toronto. He is the lead author of the study. Full research article (open access): www.cmaj.ca/lookup/doi/10.1503/cmaj.171151 ----------------------------------- Subscribe to CMAJ Podcasts on Apple Podcasts, iTunes, Google Play, Stitcher, Overcast, Instacast, or your favourite aggregator. You can also follow us directly on our SoundCloud page or you can visit http://www.cmaj.ca/page/multimedia/podcasts.

Mirza Cifric is the Co-Founder and Chief Executive Officer or Veritas Genetics, one of the most innovating companies in the biotech industry. Mirza is a life sciences entrepreneur. Formerly CEO AbVitro, Head of Corp. Dev. FORMA Therapeutics.   About Veritas Genetics: Veritas is a passionate and dynamic group of scientists, engineers, genetic counselors, business folk, and designers. Their goal: empower people to live healthier, longer. But, their story began in the 1970s with a young student passionate about one thing, DNA. George Church's work set in motion countless genetic discoveries, including the Human Genome Project, the first initiative to map all genes in the human genome. George, along with a group of visionaries and scientists, including leaders from Harvard Medical School's Personal Genome Project, co-founded Veritas.

Mirza Cifric is the Co-Founder and Chief Executive Officer or Veritas Genetics, one of the most innovating companies in the biotech industry. Mirza is a life sciences entrepreneur. Formerly CEO AbVitro, Head of Corp. Dev. FORMA Therapeutics.   About Veritas Genetics: Veritas is a passionate and dynamic group of scientists, engineers, genetic counselors, business folk, and designers. Their goal: empower people to live healthier, longer. But, their story began in the 1970s with a young student passionate about one thing, DNA. George Church's work set in motion countless genetic discoveries, including the Human Genome Project, the first initiative to map all genes in the human genome. George, along with a group of visionaries and scientists, including leaders from Harvard Medical School's Personal Genome Project, co-founded Veritas.

PANELISTS: JASON BOBE Jason Bobe is Associate Professor and Director of the Sharing Lab at Icahn Institute at Mount Sinai. For the past 10 years, Jason has been at the forefront of innovative data sharing practices in health research. His work on the Personal Genome Project at Harvard, and now three other countries, pioneered new approaches for creating well-consented public data, cell lines and other open resources. These efforts led to important changes in the governance of identifiable health data and also led to the development of valuable new products, such as NIST's standardized human genome reference materials (e.g. NIST RM 8392), now used for calibrating clinical laboratory equipment worldwide. More recently, he co-founded Open Humans, a platform that facilitates participant-centered data sharing between individuals and the health research community. At the Sharing Lab, he attempts to produce health research studies that people actually want to join and works on improving our understanding of how to make great, impactful studies capable of engaging the general public and achieving social good. He is alsothe leader of the Resilience Project, an effort leveraging open science approaches to identify and learn how some people are able avoid disease despite having serious risk factors. Last year, he was selected to be in the inaugural class of Mozilla Open Science Fellows. He is also co-founder of two nonprofits: Open Humans Foundation and DIYbio.org. SOPHIE ZAAIJER Dr. Sophie Zaaijer is a Postdoctoral Researcher in the Erlich's lab at the New York Genome Center and Columbia University. Sophie is from the Netherlands, where she did her undergraduate in Music (viola) and Food Technology. For her Masters, she studied Medical Biotechnology at Wageningen University and went to Harvard Medical School to finish her thesis work in Monica Colaiacovo's lab. She next went on to do a PhD in Molecular Biology and Genetics in Julie Cooper's lab at Cancer Research UK, London (now the Crick Institute) and at the National Institutes of Health, Bethesda. Sophie focuses on genome technology and the growing impact of genomics on our daily lives. MODERATOR: HEATHER DEWEY-HAGBORG Heather Dewey-Hagborg is a transdisciplinary artist and educator who is interested in art as research and critical practice. Her controversial biopolitical art practice includes Stranger Visions in which she created portrait sculptures from analyses of genetic material (hair, cigarette butts, chewed up gum) collected in public places. Heather has shown work internationally at events and venues including the World Economic Forum, Shenzhen Urbanism and Architecture Biennale, the New Museum, and PS1 MOMA. Her work has been widely discussed in the media, from the New York Times and the BBC to TED and Wired. She is an Assistant Professor of Art and Technology Studies at the School of the Art Institute of Chicago and a 2016 Creative Capital award grantee in the area of Emerging Fields. INTRODUCTION: DANIEL GRUSHKIN Daniel Grushkin is founder of the Biodesign Challenge, an international university competition that asks students to envision future applications of biotech. He is co-founder and Cultural Programs Director of Genspace, a nonprofit community laboratory dedicated to promoting citizen science and access to biotechnology. Fast Company ranked Genspace fourth among the top 10 most innovative education companies in the world. Daniel is a Fellow at Data & Society. From 2013-2014, he was a fellow at the Woodrow Wilson International Center for Scholars where he researched synthetic biology. He was an Emerging Leader in Biosecurity at the UPMC Center of Health Security in 2014. As a journalist, he has reported on the intersection of biotechnology, culture, and business for publications including Bloomberg Businessweek, Fast Company, Scientific American and Popular Science.

GEORGE CHURCH (https://www.edge.org/memberbio/george_church) is a professor of genetics at Harvard Medical School and director of the Personal Genome Project. The Conversation: https://www.edge.org/conversation/george_church-the-augmented-human-being

In his book, Misha Angist takes you through his experience as the fourth subject in the Personal Genome Project, George Church’s ambitious plan to sequence the entire genomic catalog: every participant’s twenty thousand–plus genes and the rest of his or her six billion base pairs. He shares his thought process on deciding to be a participant and contemplates the advantages and disadvantages. This journey takes you through Angist discovering his variants and what disease he was at a higher risk for.

Dr. Church performed his undergraduate studies in Chemistry and Zoology at Duke University before moving on to Harvard University for his MA and PhD in Biochemistry and Molecular Biology. He is now a Professor of Genetics at Harvard Medical School and Professor of Health Sciences and Technology at Harvard University and the Massachusetts Institute of Technology. His work has led to advancements in the next generation of genome sequencing and synthesis of cell and tissue engineering, with the result being that he has either founded, co-founded, or advised 22 biotechnology companies. He has started the Personal Genome Project to seek volunteers to have their personal genome made publicly available. He is Director of the US Department of Energy Center for Bioenergy at Harvard and MIT and Director of the National Institutes of Health Center for Genomic Excellence at Harvard. With 50 patents and 270 papers published, 2011 saw Dr. Church's election the National Academy of Science. He recently released a book, co-written with Ed Regis, titled Regenesis: How Synthetic Biology Will Reinvent Nature and Ourselves. We asked Dr. Church to join us to discuss how advancements in synthetic biology will impact our lives, the challenges left to overcome, and the ethical considerations involved. Do listen in!

Dr. Church performed his undergraduate studies in Chemistry and Zoology at Duke University before moving on to Harvard University for his MA and PhD in Biochemistry and Molecular Biology. He is now a Professor of Genetics at Harvard Medical School and Professor of Health Sciences and Technology at Harvard University and the Massachusetts Institute of Technology. His work has led to advancements in the next generation of genome sequencing and synthesis of cell and tissue engineering, with the result being that he has either founded, co-founded, or advised 22 biotechnology companies. He has started the Personal Genome Project to seek volunteers to have their personal genome made publicly available. He is Director of the US Department of Energy Center for Bioenergy at Harvard and MIT and Director of the National Institutes of Health Center for Genomic Excellence at Harvard. With 50 patents and 270 papers published, 2011 saw Dr. Church's election the National Academy of Science. He recently released a book, co-written with Ed Regis, titled Regenesis: How Synthetic Biology Will Reinvent Nature and Ourselves. We asked Dr. Church to join us to discuss how advancements in synthetic biology will impact our lives, the challenges left to overcome, and the ethical considerations involved. Do listen in!

Duke University geneticist Misha Angrists genome is a public document, thanks to his participation in Harvard's Personal Genome Project. Angrist reflects on the medical and ethical implications of the project in his 2010 book, Here is a Human Being: At the Dawn of Personal Genomics.

Brooklyn Beep Marty Markowitz begins our look at the boroughs. Politico’s Ben Smith on the State of the State. Fast Company’s Andrew Penenberg on video game ubiquity. Geneticist Misha Angrist on the Personal Genome Project.

Dr. Misha Angrist, Assistant Professor of the Practice at the Duke University Institute for Genome Sciences & Policy

HMS professor David Altshuler discusses the relationship between human genetic variation and disease, and HMS professor George Church explains the complexities of the Personal Genome Project. Plus, we learn whether drug sales are influenced by direct-to-consumer advertising. For supplemental information, listen to an extended interview (mp3) with David Altshuler.

HMS professor David Altshuler discusses the relationship between human genetic variation and disease, and HMS professor George Church explains the complexities of the Personal Genome Project.

HMS professor David Altshuler discusses the relationship between human genetic variation and disease, and HMS professor George Church explains the complexities of the Personal Genome Project.