Podcasts about umass

Matt Brown (@MattBrownEP) goes over some of the things he learned from going to UMass' win over UConn and what it says about some programs at the bottom of the FBS ranks. Then he and co-host Bryan Fischer (@BryanDFischer) discuss other college athletics issues like the proposed CUSA/American/Sun Belt regional reorganization plan and other realignment moves that could be made.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

(3:00) No let up at practice (6:00) Will they treat UMass like a scrimmage a la JSU? (11:00) Miami matchup, hardest remaining game, 4-2 finish? (21:00) On uniforms (25:00) Midseason "grades" (37:00) Best FSU "big 3" (41:00) OL, young guys you'd like to see play vs UMass (46:00) Why the confidence they won't regress? (53:00) Favorite 'Nole (1:02:00) So what changed over the last few weeks? Music: Positive K - I Got A Man Learn more about your ad choices. Visit megaphone.fm/adchoices

Matt and Tyler kick off the team preview series by diving into the keys and questions for St. Bonaventure, Rhode Island, UMass and Fordham

In case you missed it, Arcand gets you caught up on all the latest including UMass football's first win of the season, a school having a problem with Iron Maiden, and a story of a man in a tree. 

WE APPRECIATE EACH AND EVERY ONE OF YOU! If you wouldn't mind please go leave us a review on Apple Podcasts! Thanks! Welcome back to Episode 164 of On the Spot Sports and in today's episode we have a very special guest, current professional hockey player, Jake Gaudet! Jake and I talk about his path to pro hockey playing in the AHL with the Cleveland Monsters. We also talk about winning the National Championship with U-Mass this past season before turning pro, having good habits which leads to winners, going through injuries and coming back stronger, having the community get behind U-Mass and help them have success, finding your role, finding ways to create chemistry during the Covid season and so much more! We hope you guys enjoy this episode!! Thank you Jake for coming on the show! I had a blast! Follow us on Instagram @on_the_spot_sports and take a listen on YouTube, Spotify and Apple/Google Podcasts @ On The Spot Sports Get $25 off our guy Jamie Phillips Nutrition book for Hockey Players with the discount code "ONTHESPOT" on victoremnutrition.com Living Sisu link: https://livingsisu.com/app/devenirmem...... *BECOME A MEMBER TODAY*

UMass commit Chris Delaney joins the show! We discuss his commitment to the Minutemen, his first year in the USHL and what it was like growing up in Massachusetts! 

Picking the best bets for the college football week's worst games, from UConn at UMass to South Carolina at Tennessee. Can Florida State's incompetent offense cover a double-digit spread against North Carolina? How bad will Wisconsin boat race Illinois? And can Chip Kelly and UCLA cover 16 playing against whatever the hell is left of Arizona's football program?   Sign up today at MyBookie.com and use promo code DRINKINBROS to get your first-ever deposit matched dollar-for-dollar.   Ghostbed.com/DrinkinBros   Kill Cliff is offering Drinkin' Bros an exclusive offer, 30% off, go to KillCliff.com and use promo code DRINKINBROS.

Hosts Matt Brown (@MattBrownEP) and Bryan Fischer (@BryanDFischer) embrace their inner sickos and dive into the bottom end of the FBS ranks to discuss programs like UConn, UMass, New Mexico State, UTEP, Akron and more. Where challenges do these college football programs face and where can they go in the coming years? See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

On this episode of the DJ Morgan Show, DJ recaps the weekend in Nashville against Vanderbilt, the team putting complete games together and getting closer to breaking through with a win, preparing for UMass and more.

Is it even possible for a sophomore to manage a $2 million business? On today's show, we interview Kevin Hiselman who shares with us his distilled wisdom on perseverance, and overcoming your fears. You will learn how Kevin managed a $2 million painting business while he was a sophomore at UMass, Amherst. Kevin was first introduced to YEAA when he was taking classes at UMass. And while he has eager to sign up immediately, he had to fight off the initial scepticism from his friends and family. One of the biggest things that attracted Kevin to the internship was the opportunity to get mentored by folks who were just slightly older than him. In his first year with YEAA, Kevin ran a $110,000 business and earned $20,000 in profits. As a district manager in his second year, he dramatically scaled up his business to $2 million in revenues and $110,000 in profits. Topics discussed on today's show include overcoming your fear of running a business, cultivating leadership skills, and learning responsibility and accountability. You do not want to miss this one. Enjoy! What You Will Learn In This Show What does it take to successfully complete a YEAA internship? Why YEAA is the most fun experience that you can ever have How the YEAA internship taught me responsibility and maturity How I ran a $2 million painting business at YEAA And so much more… Resources: YEAA Website Facebook LinkedIn Instagram

- The guys recap a great week 5 and discuss what has the potential to be a crazy week 6. 

Ross Tucker & Emory Hunt preview the following games in College Football for this weekend including: Oklahoma vs. Texas (1:35) Michigan State at Rutgers (8:35) Penn State at Iowa (11:04) UConn at UMass (15:45) Download the DraftKings Sports Book App and use code ROSS for a sign up bonus up to $1,000 Connect with the Pod Website -  https://www.rosstucker.com Become A Patron - https://www.patreon.com/RTMedia Podcast Twitter - https://twitter.com/RossTuckerPod Podcast Instagram -  https://www.instagram.com/rosstuckerpod/ Ross Twitter -  https://twitter.com/RossTuckerNFL Ross Instagram -  https://www.instagram.com/rosstuckernfl/ Learn more about your ad choices. Visit megaphone.fm/adchoices

The guys (@GamblgingPodcast) give out their college football picks for week 6. The college football predictions episode hits on a number of big games including, Penn State at Iowa, Arkansas at Ole Miss and UCONN at UMASS. Then they're joined by Johnny Guinta (@AJohnnyGiunta47) to talk all things college football betting and much more. Subscribe to The College Football Experience w/ Colby Dant -> https://sg.pn/tcfe Get all of our College Football Picks in the SGPN APP today https://sgpn.app and leave us a rating/review. Hosts - Sean Green | Ryan Kramer Guest - Colby Dant Follow - Twitter | Instagram Watch - YouTube | Twitch Listen - Apple | Spotify Read - SportsGamblingPodcast.com Discuss - Slack | Reddit Support for this episode - WynnBet | PropSwap.com code “SGP” | Prediction Strike code SGP | Oddscrowd.com Podcast Timecodes 00:00 - Prerolls 1:39 - Intro/Welcome 2:03 - SGP Contributor Colby Dant 6:27 - Matt Corral Heisman Odds 8:25 - Middle Tennessee v. Liberty Preview 10:22 - TCU v. Texas Tech Preview 12:30 - UConn v. UMass Preview 15:14 - Wisconsin v. Illinois Preview 17:29 - SMU v. Navy Preview 20:22 -Texas A&M v. Alabama Preview 26:51 - Oklahoma v. Texas Preview 30:28 - Arkansas v. Mississippi Preview 36:06 - Georgia v. Auburn Preview 39:56 - Penn State v. Iowa Preview 46:02 - Nebraska v. Michigan Preview 48:41 - Notre Dame v. Virginia Tech Preview 52:44 - LSU v. Kentucky Preview 55:39 - Lock, Dog, Tease, Bonus Lock, and Norm Salute Parlay 1:02:19 - Host of Blue Wire Podcast Officially Unofficial Johnny Giunta Learn more about your ad choices. Visit podcastchoices.com/adchoices

On today's episode of Locked on Boston College we look at a variety of topics heading out of last weekend's tough loss to Clemson. First we look at the good, bad and ugly from the game. Who were the two real standouts for the Eagles, and what got the negative labels. Secondly, we look at Dennis Grosel. Many folks have been calling for the quarterback to be benched, but we explain why that may not be the best answer. Hear why it's great to love the backup quarterback, but once they get on the field it's a different story. Finally, Mitch Wolfe stops by again and talks about other games from around the country, including Wake Forest defeating Louisville, and our favorite segment, "What happened to UMass and Uconn football! All of this and more on today's show. Support Us By Supporting Our Sponsors! SweatBlock Get it today for 20% off at SweatBlock.com with promo code LockedOn, or at Amazon and CVS. Built Bar Built Bar is a protein bar that tastes like a candy bar. Go to builtbar.com and use promo code “LOCKED15,” and you'll get 15% off your next order. BetOnline AG There is only 1 place that has you covered and 1 place we trust. Betonline.ag! Sign up today for a free account at betonline.ag and use that promocode: LOCKEDON for your 50% welcome bonus. Rock Auto Amazing selection. Reliably low prices. All the parts your car will ever need. Visit RockAuto.com and tell them Locked On sent you. Learn more about your ad choices. Visit podcastchoices.com/adchoices

Risa Isard is a sports industry veteran and policy expert. She specializes in advancing equity with and for girls and women, LGBTQ+ people, people of color, and others in and through sport. Her career in the sports industry spans professional and college sports, sports policy, and nonprofit thought leadership. She has developed partnerships with professional ninja athletes, hosted Billie Jean King in an on-stage conversation, directed the premier national event for increasing access to youth sports, co-authored and edited foundational research reports, established community-based partnerships to support sport leaders across the country, launched a first-of-its-kind online portal for community leaders, founded a farmer's market at professional baseball games, run a baseball league for people with special needs, hosted a celebrity soccer challenge, authored fortune cookies, and more. She is the former associate director of thought leadership for national nonprofit KABOOM!, former project director for the Aspen Institute Sports & Society Program, and former community relations coordinator for a minor league baseball team. She's also been on staff at Brandi Chastain's nonprofit organization, Duke University women's basketball, and the Phoenix Mercury. Risa has presented at South by Southwest (SXSW), Spotlight: Health at the Aspen Ideas Festival, the Surgeon General's Innovation Summit, the University of Pennsylvania's Law School Sports Symposium, the North American Society for Sport Management, and elsewhere. She has written for Sports Business Journal, AdWeek, Global Sport Matters, Quartz, espnW and elsewhere. Risa graduated cum laude from Duke with a specialized degree in “Social Change at the Intersection of Culture, Gender, and Sports,” simultaneously receiving honors for her original research thesis on the pre-history and early years of Title IX (1969-1975). A long-time advocate of using sports for social change, Risa is a Research Fellow in the Laboratory for Inclusion and Diversity in Sport at UMass, where she is currently pursuing a Ph.D. in Sport Management from the Isenberg School of Management. Quotes: --“This is definitely not sport-specific. Racial bias has long been documented in men's sports. There is less documentation, but no less convincing evidence, that it happens in women's sports as well. It can manifests in a number of different ways. It can be about the attention athletes get, it can be about the kind of attention they get, and it can be about the language we use when we talk about athletes...Absolutely, racial bias is pervasive in and across sports, and in women's sports." --“Title IX has fixed things unequally when it comes to girls. Title IX has been excellent for white, middle-upper class girls like me. It has been a lot less effective at creating equity for Black girls, Latinx girls, girls of color broadly, and girls from low income communities. The gender gaps that exist in some communities are still quite pervasive…Title IX, at its best, ought to create a more equitable society for all girls, and it hasn't done that yet.” Follow Risa on Twitter: @RisaLovesSports Follow Social Sport: Website, Instagram, Facebook, Twitter, Newsletter --- Support this podcast: https://anchor.fm/socialsport/support

Umass Darthmouth has been building a solid program. And with Providence Rhode Island not far away, Smart move for the university to bring in a local football recruiter form Rhode Island. --- Send in a voice message: https://anchor.fm/canwekeepitreal/message Support this podcast: https://anchor.fm/canwekeepitreal/support

The Eastern Insider Podcast is back, and this week's edition is jam-packed with great interviews >Alex Jewell and Greg Steiner open the show with all that you need to know from around athletics, and their breakdown of EMU Football's Week Three matchup with UMass and the upcoming Texas State game. > Chris Creighton takes you inside his office as he preps his team for a big week against Texas State > WEMU's Tom Helmer sits down with Sterling Roberts to learn about his Olympic experience.

When a peacock fugitive is on the run, only the BPD can step in to restore justice. Or, just, sometimes peacocks like to escape the zoo. At least that's what is true in Kelly Noonan's experience. Kelly is a good friend, excellent writer, and real cool person. She shares real life peacock stories, real life Poshmark woes, and some deep introspection on this weeks episode. 

A $175 million historic gift from The Morningside Foundation to UMass Chan Medical School was announced on Tuesday, Sept. 7, with a press event at the UMass Club in Boston. Listen to the full press conference in this podcast episode. For more: https://www.umassmed.edu/umasschan/

Kennedy wants to know what you would have custom made, Karson found an interesting question about a bad kid on Facebook, Annie discusses the U-Mass fraternity protest and Producer Dan brings random topics. See omnystudio.com/listener for privacy information.

The Eastern Insider Podcast is back, and this week's edition is jam-packed with great interviews >Alex Jewell and Greg Steiner open the show with all that you need to know from around athletics, and their breakdown of EMU Football's Week Three matchup with UMass and the upcoming Texas State game. > Chris Creighton takes you inside his office as he preps his team for a big week against Texas State > WEMU's Tom Helmer sits down with Sterling Roberts to learn about his Olympic experience.

Filip Lindeberg's new to the pros, but he's 22 years old and fresh off a UMass title ... which means he won big games.  Learn more about your ad choices. Visit megaphone.fm/adchoices

Matt and Matt are back to break down a tough week for BC fans, as we try to inject some positive vibes and look ahead to the Denny Show on Saturday. Hope is not lost, we have the best QB2 in the country, and we're ready to #ShockTheWorld. Our good friend Sean Sylvia joins the show this week to breakdown what's wrong with the defense, talk about what this type of injury does to the locker room, and give his much-anticipated thoughts on Colorado State. It's still a great day to be an Eagle - Get In, Folks!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This month on Episode 28 of Discover CircRes, host Cynthia St. Hilaire highlights four original research articles featured in the August 20th and September 3rd issues of Circulation Research. This episode also features an in-depth conversation with Dr Scott Cameron from the Cleveland Clinic and Dr Milka Koupenova from the University of Massachusetts Medical Center about their study, SARS-CoV-2 Initiates Programmed Cell Death in Platelets.   Article highlights:   Gupta, et al. Electronic Cigarettes and Oxidized Lipids   Bartosova, et al. Glucose Derivative Induced Vasculopathy in CKD   Atmanli, et al. DMD Correction Attenuates Cardiac Abnormalities   Ma, et al. Length Dependent Activation in Porcine Myocardium   Cindy St. Hilaire:        Hi, and welcome to Discover CircRes, the podcast for the American Heart Association's journal, Circulation Research. I'm your host, Dr Cindy St. Hilaire from the Vascular Medicine Institute at the University of Pittsburgh, and today I will be highlighting articles presented in our August 20th and September 3rd issues of Circulation Research. I also will speak with Dr Scott Cameron from the Cleveland Clinic and Dr Milka Koupenova from the University of Massachusetts Medical Center about their study, SARS-CoV-2 Initiates Programmed Cell Death in Platelets. Cindy St. Hilaire:        The first article I want to share is titled Electronic and Tobacco Cigarettes Alter Polyunsaturated Fatty Acids and Oxidative Biomarkers. The first author is Rajat Gupta and the corresponding author is Jesus Araujo from UCLA. E-cigarettes have surged in popularity in the last decade and while many people switching from traditional cigarettes to smokeless ones view the latter as a safe alternative to smoking tobacco, emerging data shows that E-cigarettes cause adverse effects such as oxidative stress, inflammation and endothelial dysfunction in users. The aerosols produced during vaping contain similar levels of reactive oxygen species, also called ROS, as the vapors of tobacco smoke. However, data on the extent to which E-cigarettes, E-cigarette ROS, influences cardiovascular health is lacking. Cindy St. Hilaire:        To address this, this group recruited 32 chronic users of E-cigarettes, 29 chronic tobacco smokers, and 45 individuals that used neither and they measured their plasma levels of oxidative biomarkers. The team found both similarities and differences between the E-cigarettes and the tobacco users. For example, both smoking groups had increased plasma antioxidant capacity and decreased levels of oxidized linoleic acid compared with the levels seen in non-users, while arachidonic acid levels were raised in tobacco smokers and reduced in E-cigarette users. Overall, however, the biomarker levels were deemed to be intermediate for E-cigarette users between the non-users and the tobacco users. This study suggests that while E-cigarettes carry a lower health risk than tobacco, they are by no means safe.     Cindy St. Hilaire:        The second article I want to share is titled Glucose Derivative Induced Vasculopathy in Children on Chronic Peritoneal Dialysis. The first author is Maria Bartosova and the corresponding author is Claus Schmitt and they're from the University of Heidelberg. Diabetes, high blood pressure and obesity are risk factors for both cardiovascular disease and chronic kidney disease. Worse still, loss of kidney function and even dialysis itself are thought to exacerbate cardiovascular issues. In the case of dialysis, it's thought that high levels of glucose degradation products, or GDPs, in the dialysis fluids can promote the addition of sugar moieties to vascular proteins and lipids causing vascular damage. To investigate this theory, Bartosova and colleagues studied vascular tissue from children with chronic kidney disease receiving dialysis fluids with either high levels or low levels of glucose degradation products and compared these to tissues from children not on dialysis at all. Cindy St. Hilaire:        Proteome and transcriptome analysis of the vessel tissues revealed that compared with patients or no to low GDP fluids, patients receiving high GDP fluids had higher levels of damaging glycation, increased transcription of genes involved in cell death, and decreased transcription of genes involved in cell survival and cytoskeletal reorganization. In line with these findings, vessels from high GDP patients displayed considerable evidence of damage, such as markers of apoptosis, skeletal disintegration and thickened intimas. The results confirmed GDPs can cause vasculopathy and suggest low GDP fluids should be used for dialysis patients. Cindy St. Hilaire:        The next article I want to share is titled Cardiac Myoediting Attenuates Cardiac Abnormalities in Human and Mouse Models of Duchenne Muscular Dystrophy. The first author is Ayhan Atmanli and the corresponding author is Eric Olson from UT Southwestern. Duchenne Muscular Dystrophy, or DMD, affects one in 5,000 baby boys and is caused by mutations in gene for dystrophin, an architectural protein essential for muscle cell integrity. Patients display profound muscle degeneration and weakness, with respiratory and heart muscle dysfunction being a major cause for death. With the recent improvements in respiratory medicine that extend the lives of patients, this group now focused on heart dysfunction and specifically, whether gene editing could mitigate it. The team created induced pluripotent stem cells, or iPSCs, from Duchenne Muscular Dystrophy patient and his healthy brother and showed that gene editing from the DMD cells enabled their development into normal-looking cardiomyocytes with normal contractile function and calcium handling, equivalent to that seen in healthy control cells. The unedited DMD cells, by contrast, did not develop normally. For great clinical relevance, the team edited DMD cells after cardiomyocyte differentiation showing that this reduced their propensity for arrhythmia, compared with that of unedited cells. Cindy St. Hilaire:        Lastly, the team provided evidence to suggest gene editing may improve heart abnormalities in mice with the same mutation. All together the results are proof of principle and support of the development of gene editing therapy as treatment for DMD. Cindy St. Hilaire:        The last article I want to share is titled The Super-Relaxed State and Length Dependent Activation in Porcine Myocardium. The first authors are Weikang Ma and Marcus Henze and the corresponding author is Thomas Irving and they're from the Illinois Institute of Technology. Myofilament length-dependent activation or LDA is the fundamental mechanism coupling the force of the heart's contraction to it's proceeding diastolic volume. In other words, LDA ensures that the more the heart fills, the stronger it contracts. Studies of rodent hearts have given insights into LDA mechanics. However, how it operates in large mammalian hearts is unknown. Using structural and biochemical analysis of pig myocardial fibers, this group found that compared with small stretches of the fibers which were equivalent to small diastolic volumes, long stretches induced greater ATP turnover and greater numbers of cross bridges between myosin and actin filaments which are critical contractile machinery proteins. Cindy St. Hilaire:        Myosin motors can be found in three stages, engaged with actin, unengaged in a disordered, relaxed state but ready to engage, or super-relaxed state where they are essentially switched off. The team showed that as muscle stretch increased, the amount of super-relaxed myosin motors diminished with more myosin motors becoming engaged to enable a stronger contraction. When the fibers were treated with a myosin motor inhibitor, these stretch effects were impaired. In revealing the mechanisms of myofilament length-dependent activation, this study provides a platform for studying cardiomyopathies in which this system goes awry. Cindy St. Hilaire:        So today, Dr Scott Cameron from the Cleveland Clinic and corresponding author of the paper, Dr Milka Koupenova from the University of Massachusetts Medical Center, are both with me to discuss their study, SARS-CoV-2 Initiates Programmed Cell Death in Platelets. And this article is in our September 3rd issue of Circ Research and for full disclosure, the editor of Circ Res, Dr Jane Freedman is also an author on this manuscript. And for full double disclosure, I know Dr Koupenova quite well as we were both graduate students together back in the Ravid Lab at Boston University. However, the full Editorial Board selects these articles, not just me alone and this one is timely, novel, and an amazing story. So thank you both for joining me today. Milka Koupenova:       Thank you for having us. Scott Cameron:           Privileged to be here. Cindy St. Hilaire:        So before we jump into the story that is your paper, can you give us a little bit of background about platelets? I know for years, I guess certainly before Katya's lab, I just thought of platelets as little nucleus-free particles that clot. But we know they are so much more than that. So why are they so important? And how do they function to do more than just stop a bleed? Milka Koupenova:       So this is a great question, Cindy, and I am happy that you alluded exactly to the anucleated nature of platelets. So platelets are cell fragments. They're precursors in the bone marrow, the megakaryocyte. They are the second most abundant blood component after the red blood cells. And traditionally, platelets have been known, as what you pointed out, as these little units that change their conformation once there is some form of a problem with either the vascular, which we have a cut, they come together, they form this clot, and bleeding is prevented. But as we have learned perhaps in the past 20 years that platelets have a profound immune role during various immune processes and infections for different kind of microbes. And particularly relevant to this paper is that we understand that platelets have clearly a role responding to the viruses and activating the immune system. Cindy St. Hilaire:        Yeah, and that was actually my next question. You and Jane are the world-leading experts on platelets and viral responses. So what was known about that interaction, I guess before we started looking at SARS-CoV-2, what was known about that platelet virus or even type of virus interaction? Milka Koupenova:       So SARS-CoV-2 is a RNA virus--respiratory virus that we actually thought similarly to influenza that it mostly stays in the lower respiratory tract where it becomes problematic. However, from our work with influenza, when we saw that in certain patients you actually can detect the virus in platelet. In the beginning of the pandemic, we hypothesized that perhaps, in some people, the virus crosses over into the circulation. And based on our previous studies with influenza, we wanted to see if that indeed is the case. Hence we initiated a study here at UMass with the department head who is also on the paper, Dr Finberg, who is a leading expert in influenza and novel virus and we collected platelets from people to see if we can detect it. And so in the beginning, we were not able to detect SARS-CoV-2 in platelets. So we collected platelets from 17 patients and by qPCR with the primers that the CDC has, for whatever reason I couldn't detect anything. And I was really frustrated because previous reports have shown that about 25%, in some people even 35% of the study population, SARS can be detected. So very interesting observations. Milka Koupenova:       I could see it by immunofluorescence but I couldn't detect the RNA. And the story goes, that I attended a seminar on SARS-CoV-2 and the person was actually referencing a company that started from University of Pitt where you are. Cindy St. Hilaire:        Oh, very nice. Milka Koupenova:       And they do specific, it's called amplicon ARTIC v3 sequencing so they enrich for the SARS-CoV-2 RNA and screen by sequencing. And when we did that, we were able to detect it in all patients. So I freaked out and I said, "Oh my gosh, something is wrong." Milka Koupenova:       And so I sent plasma, and I sent controls, and actually RNA from the virus and you can see beautifully that it's only in platelets. Four of the 17 people actually had RNA in the plasma, but what you can observe in all these people is that the virus is fragmented, meaning it's not infectious. And in a way what this tells us, it suggests that platelets are super important in the removing it from the circulation and they probably serve as a dead-end for the virus because you cannot find virus coming out of platelets and the RNA is chopped off. So what I would say, is that platelets are these amazing little units that serve as removal of the viral RNA for these particular viruses, respiratory viruses that are RNA viruses. Cindy St. Hilaire:        I think that is so interesting. So essentially, they're almost like little composters that are chewing it up and preventing it from spreading in the organism. Milka Koupenova:       Yes, and as a result there is a response. Cindy St. Hilaire:        Scott, probably the most common thing that people know with SARS is that loss of smell, or taste, and things like that, but really that doesn't send anybody to the hospital. So really what are the symptoms of COVID-19 patients that tie in with platelets specifically? I feel like that's a lot of things that we maybe in the public, or on Twitter, and things didn't hear as much about. So really what are those big symptoms linking COVID and platelets and what are the implications of platelet death in the pathogenesis of COVID? Scott Cameron:           So certainly I think several investigators are in the world of now showing that platelets are hyperactivated, Robbie Campbell and Matt Rondina put a really nice paper in Blood last year showing that platelets are hyperactive and there are other investigators who found something similar. And so the question is, what are the symptoms of hyperactive platelets in the SARS-CoV-2 patient? So what most of them would find is shortness of breath or dyspnea, and when they present to the emergency department, and certainly we saw this, the oxygen saturation which should be in the mid to high 90s on room air on an average person, was quite often low. It was in the 80s or 70s, sometimes even the 60s. Scott Cameron:           And the real surprising thing was those are patients that would normally immediately be on a ventilator, but yet they could still be talking to you. And so if you have a platelet that's activated in a hyperthrombotic condition, like SARS-CoV-2, COVID-19, and then that forms a blood clot, you have a situation where the amount of oxygen the patients taking in and the amount of oxygen you're measuring in the artery is quite discrepant and we call that the alveolar arterial or oxygen gradient. So if you've got lots of platelet plugs through the microvasculature, it's going to take up some space the oxygen should be using for diffusing in. And so that would be manifested as shortness of breath and that's certainly one of the biggest tip-offs that a patient might have a blood clot, particularly in the lung. Cindy St. Hilaire:        Some of these symptoms of COVID-19 are really worse in patients with comorbidities, diabetes, obesity and heart failure. Are platelets central to kind of the pathogenesis of those disease or the symptoms of those diseases? I guess the root of my question is, why do the comorbidities of diabetes, obesity, and heart failure make COVID worse? Is it something about those disease states themselves or is there a role for platelet? Scott Cameron:           That's a brilliant question, no one's ever asked that before. And as Dr Koupenova said, I'm a little bit biased too because I firmly believe that in different disease states, the disease educates the platelets so you've got a different platelets phenotype. So focusing on diabetes, we know the platelet phenotype is different in diabetic patients. We know that platelet reactivity seems to be higher through the P2Y12 receptor.  In terms of obesity, it is true, we know that, and this has been published also, and we know that the platelet phenotype is hyperactive in a patient with obesity and so that tells me that, that's a comorbidity that might affect platelet function and also vice versa for that case. And then in terms of why is it affecting males more prominently and more severely than females, well one of the beefs, I guess, that I had is that we treat diseases in women the same as we do in men assuming that the platelet phenotype in disease must be the same, but that's absolutely not true. And that's actually a theme that we have in our lab right now, we know that the behavior of platelets, and how platelets are educated in diseases is not all the same in women as in men and I think it's a huge disservice that we really had to have a pandemic that would make that quite clear to us. Cindy St. Hilaire:        You kind of hit onto something that's really, I think it's now becoming more recognized certainly in the cardiovascular field and that is so many studies are really only on male mice, or only younger or older men, and we are missing not only a huge patient population, but probably some really interesting biology that is distinct. Milka Koupenova:       So expanding on that, we know that in platelets, the toll-like receptors, and we've looked at the expression of all 10 in a study that we published in ATVB in 2015, actually, significantly if you look at Farmingham Heart Study data and the expression of these toll-like receptors they are increased in women versus men. And also, an interesting observation that never got published, once upon a time when I was doing studies with TLR7 mice is that if you inject TLR7 agonists, male mice would have a higher level of reduced platelet count than female mice at the same time points, right? And at that time it wasn't published. Definitely there are differences, but I also want to extrapolate a little bit on what was said at the beginning. We have to understand that when it comes to these comorbidities, everything affects a unit that doesn't have a nucleus, right? And diabetes and obesity have the so called profound, chronic inflammation of cytokines, such as IL6, that keep circulating. These things have effect on platelets. So we have two responses, we have the environment that affects platelets and we have the direct response of the virus that affects platelets. And that cumulative response truly can exhaust them and once they become exhausted, once they release their contents, as we show in this paper, then you're compromising their function and you will be compromising taking out the virus from one side and from the other side you're going to be compromising the environment because all of the content that comes out from a unit that already has free form proteins, it exhibits a true insult on what's being surrounded. So these clots that form in the lung or the platelets that circulate they no longer can be resolved properly. Cindy St. Hilaire:        Yeah. Milka Koupenova:       It's a balance. Cindy St. Hilaire:        Yeah, so really it's like destroying the platelet not only are you destroying the vacuum that has to suck up those particles, you're then just dumping a whole bunch of pro-inflammatory things on all of the endothelial cell vasculature that those platelets are nearby. Cindy St. Hilaire:         Actually that was one thing that I thought you spent a decent portion of the discussion on, and that is the method by which the blood is collected really impacts the outputs you observe in quote unquote platelets. Can you talk about the importance of that because I think that's one thing, certainly as a PhD who's just like, "Oh, yeah. I'm just going to collect blood from my mice and do this thing," how critical is that point in the experiment, in the blood collection? Milka Koupenova:       So I am very adamant when it comes to platelets for the blood to be drawn in citrate. And I have to say that a lot of the studies that you would see in the literature are done using EDTA blood or serum. They all have their importance. I'm not going to dismiss it, but if you want to truly measure what's inside in plasma, versus what's inside in platelets, or what's inside in any cell for that matter, you got to go for citrate. You have to be very careful not to shake the blood. You have to be very careful not to cool down the blood. So the nurses probably hated me because often I would be like, "You can't do this. You can't put it on ice. You can't warm it up to above certain degrees. Everything has to be controlled and done correctly." Milka Koupenova:       And so I had done in the past studies in which I would take plasma from the same patient in EDTA, in citrate and then isolate the RNA, have my tech isolate the RNA, and we send it to a fragment analyzer, and you can see how much more RNA you will get in the EDTA plasma. I'm not even talking about serum. Milka Koupenova:       Serum is a very different thing, then you're definitely going to get platelet content in it, in the serum, right? So it's important to distinguish that perhaps when you're getting EDTA plasma you are looking at a content that could have been inside in platelet and I can't stress enough that when it comes to these particular studies, citrate, dextrose, phosphate is your place to go and be. Cindy St. Hilaire:        So in terms of translational potential, what do your findings suggest about future therapies or targets to investigate as therapy? And is modulating platelets a potential for combating viral infections or mitigating their severity? Milka Koupenova:       Well, Scott and I actually talk a lot about that. Scott Cameron:           That's right. Milka Koupenova:       I personally would say, control the inflammation, never let it go to platelet. Let me back up a little bit, if you have to, you have to, right? But your go to method should be inflammation, if you don't get to the point that you need to control platelets then you're in a better place because it becomes very fickle. From everything that you hear me say, you push it to one side and the balance is destroyed. You deactivate platelets or inhibit platelets well, are they now not able to pick up the virus and then you're now having the virus circulating somewhere. Now, if you don't treat platelets that's also not good. So you're in the very fickle situation if you get to the point that you need to control the activation of platelets and there are trials currently that are trying to look at those things. Scott, I'm going to refer this a little bit more to you because you have done some interesting things with that particular point. Scott Cameron:           No, it's a great question, Milka, and I think that as platelet biologists, nobody more than I wanted it to be true that platelets would be the ultimate target. I mean, clearly patients with SARS-CoV-2 have thrombosis, clearly platelets are activated, so should we inactivate them? That was the whole point of the RECOVERY trial and one of the benefits I'll tell you before I sort of go into that is, working in a large organization like the Cleveland Clinic and we have access to data and lots of it extremely quickly, and so because of that I of course could see how many patients were coming into our hospital with thrombotic events. And I could see what the independent predictors of thrombotic events was and it wasn't the platelet count, sometimes platelet count was low, sometimes it's high in the SARS-CoV-2 patient. And if you took those individuals that were on aspirin, comparing them to those that are not in a propensity match study,  one of the things that we find is that aspirin doesn't seem to affect or improve mortality or the number of blood clots in the patient with SARS-CoV-2. Scott Cameron:           We compared that to all non-steroidal anti-inflammatory medications that patients may have been taking also in a propensity match study just in case it was the mechanism action of the drug, rather than the drug itself, and we found that NSAIDs not only did not protect patients, but they were not necessarily harmful either, which was one of the things that came out at the start of the pandemic. Among, I'll add, the absence of evidence based medicine and a lot of cases where naturally people, including clinicians, were scared and so they were going off label and they were trying a lot of different medications with really not a shred of randomized controlled data. Scott Cameron:           But now that we're 18 months into it, the first and biggest study that came back was the RECOVERY trial, which we were all waiting on, where patients were given aspirin and short term mortality was examined over an observational period of one month. And just like we found in a propensity match study, which is as close as you'll get to a clinical trial in a retrospective manner, the prospect of RECOVERY trial actually showed the curves were almost super imposeable, those that got aspirin versus those that didn't. So I think low dose aspirin clearly is not going to be enough for those patients, but I'll also add that over the observational period of one month they also didn't see a higher incidence of death in those patients. And I think Milka's point is really well taken that you have to remember that as well being an entity of thrombosis, platelets are immunological entities and so you've got to really consider should we be inhibiting them and if you are inhibiting them, I think the time point at which you should inhibit them is what we should examine, not just an all or nothing, inhibited or not. Milka Koupenova:       It's just in our linear brains we prefer to think of it as one straight, linear pathway, but it isn't, and I think platelets are actually a great example of how many pathways are feeding into one tiny fragment and that particular blood cell is inducing this profound response during these infections. Cindy St. Hilaire:        I think most people have heard that angiotensin-converting enzyme 2, also called ACE2 is the receptor of SARS-CoV-2. The virus itself uses it to bind and become internalized into the cell, but there's been some discussion or even some discrepancy of data as to whether platelets truly express ACE2 and if that is the means for the virus to enter the platelets. So can you share with us what is the current state of knowledge about that? Scott Cameron:           Yeah, just as a segue of some of the things that Milka said, I think the preparation of your sample is part of the answer. If you draw in the incorrect tube, if you the tube is not completely filled, and the ratio of citrates to whole blood isn't correct you're going to have discrepant results. If you biomechanically activate the platelets by drawing through a short needle, in a small-bore needle for example, that's going to activate the platelets. If you cool them, it's going to activate them. But then also, depending on how you decide to separate them, we always washed platelets in my lab, we wash them two or sometimes three times, and I can tell you if you use flow cytometer we get one white blood cell for every 12,000 platelets. Scott Cameron:           And some investigators might go one step further and they'll a CD45 depletion set, which is certainly important if you're studying RNA. But one of the issues, as you well know, a CD45 is also on the surface of platelets, so if you start with a low expressing protein and you CD45 deplete them, you are actually going to get a decrease in your platelet yields. I've seen it, I think Milka's seen it, various other investigators have, and you might find yourself at the threshold of what your antibody can detect. It's also variably expressed. If you look at even healthy individuals, some of them have almost none. So if you look at 10 individuals, you might actually find none, but then if you look at another 10, the amount of expression that we see is kind of all over the place. It's not like other receptors where one tends to express a certain amount and that's the way it is in health. ACE2 doesn't seem to be that way for whatever reason. Milka Koupenova:       We were able to detect in some of the people by qPCR, but what was interesting is that from the three primers that I used there was never the same person who we were able to detect all three primers with for that receptor. That tells you that maybe they are changes of one base that is not enough for the primer to detect it, right? That becomes another possibility of not being able to detect. Milka Koupenova:       And so I go to confocal microscopy where I use 100 lens and tons of hours in the microscope room, and Scott is completely right, it's really hard to see it particularly in healthy people. And it starts to pick a little bit more in people with cardiovascular disease or people with COVID that are old. So it's a bit complicated, but the important thing here is, besides the fact that we are detecting ACE2 and we're detecting proteins and I use controls, biological controls to prove that this is the case and it's not just an antibody problem, is that the virus will get picked up by platelets even if you don't have ACE2. That is the take home message from this paper is that the platelet has evolved various mechanisms by which is utilizes getting it inside. It is that important for this virus. This type of virus is not recirculating. In this case, what we observed is that the virus is attached to microparticles that are of platelet origin for that matter. Cindy St. Hilaire:        So really what you're saying, what I'm hearing is the platelet is the superhero of the body. Milka Koupenova:       Definitely. Absolutely. No bias, absolutely. Cindy St. Hilaire:        Unbiasedly, it is a superhero. Well, Dr Cameron and Dr Koupenova, thank you so much not only for this amazing discussion, but for really an elegant, elegant paper that is really bringing to light the complex interaction between SARS-CoV-2 and platelets. So thank you so much for joining me and keep publishing amazing stories like this. Milka Koupenova:       Thank you for having us. Scott Cameron:           Thank you, an honor to be here. Thanks again. Cindy St. Hilaire:        That's it for the highlights from August 20th and September 3rd issues of Circulation Research. Thank you for listening. Please check out the CircRes Facebook page and follow us on Twitter and Instagram with the handle @CircRes and #DiscoverCircRes. Thank you to our guests, Dr Scott Cameron and Dr Milka Koupenova. This podcast is produced by Ashara Ratnayaka, edited by Melissa Stoner, and supported by the editorial team of Circulation Research. Some of the copy text for the highlighted articles is provided by Ruth Williams. I'm your host, Dr Cynthia St. Hilaire, and this is Discover CircRes, your on-the-go source for the most exciting discoveries in basic cardiovascular research. This program is copyright of the American Heart Association, 2021. The opinions expressed by speakers in this podcast are their own and not necessarily those of the editors or of the American Heart Association. For more information, please visit ahajournals.org.  

UTEP Percussion Professor Andy Smith returns to talk about his time at UMass and working in drumlines in New England (01:20), his 9+ years going to and teaching at Middle Tennessee State, along with some timely financial advice (13:10), his time as a doctoral student at Indiana University (30:30), and interacts with the Random Ass Questions (52:20).Finishing with a Rave on the David Halberstam book The Education of a Coach (01:24:00).Links:Part 1 with Andy SmithAndy Smith's UTEP homepageAmy Smith on the podcastWill KennedyDennis ChambersJohn J.R. RobinsonCasey ScheuerellNick AngelisThom Hannum“Blue Rondo a la Turk” - Dave BrubeckSteve GaddColin McNuttBlast!Star of Indiana DCILalo DavilaJulie Davila on the podcastBrian MuellerMusic City Mystique WGICrossmenChad WymanMike SpiroSteve HoughtonKevin BoboMike MixtackiBernard WomaPaschal YoungeScott KettnerBen WahlundGuardians of the Galaxy trailerElf trailerThe Love Guru trailerTommy Boy trailerBlack Sheep trailerJames Doyle on the podcastMike SammonsSide by Side - Wiff Rudd“Message in a Bottle” - The Police“Roxanne” - The PoliceAlexis C. Lamb on the podcastRaves:The Education of a Coach - David Halberstam

Mike and Scott look back at BC's win over UMass and towards the game versus Temple. Can the Eagles improve to 3-0? Plus, how will the Eagles handle the Phil Jurkovic's injury as Dennis Grosel steps in at QB? All that and more, check it out! To advertise on the podcast, just email mike@lightscamerasports.com!

GBH News reporter Adam Reilly welcomes local political experts who are closely watching Boston's mayoral race to see which of the five candidates will face each other in the race to the November elections, in a live event taped on the eve of the election. GBH News City Hall reporter Saraya Wintersmith and WBZ political commentator Jon Keller lead the way with their reporting and historical context. Pollster Steve Koczela points out interesting data points in the race, and finally UMass political scientist Erin O'Brien meets up with Jax Van Zandt, host of the show Politics and Prosecco, to talk about the significance of the race to women and particularly women of color.

It's the Season 6 finale of Knuckleheads, y'all! And we've got a real one to close it out for you. One of the greatest ever to do it. New York legend. Rucker Park hero. Philadelphia superstar. The high-flying hooper every kid wanted to be, a man who made his mark on the sport forever with a name the game will never forget, it's JULIUS ... DR.J ... ERVING! Nothing but love for our OG. Make an appointment with the Doctor and tune in for this very special episode of Knuckleheads. Current state of basketball and player resemblances [3:00] Legendary dunking, being one of the NBA's 50 Greatest Players, nickname origin [9:15] UMASS and Rucker Park [23:45] ABA to NBA transition, first dunk contest, biggest rivalries [30:49] Effortless swagger, endorsements, racism over time [53:20] Being MJ's favorite player, Wilt Chamberlain, almost playing for the Bucks [1:04:55] About Our Hosts: NBA veterans Quentin Richardson and Darius Miles are lifelong friends and bona fide truth-tellers. Listen as they invite special guests, high-profile athletes, musicians and entertainers to get brutally honest about everything from current events to untold stories from the golden era of sports and culture. Named for the on-court celebration they made wildly popular, this unfiltered, hilarious and surprising podcast is like playing NBA 2K with no fouls. Other places to find Knuckleheads:  Subscribe on Youtube: https://www.youtube.com/watch?v=e_oEpHy1IGw Follow on Instagram: https://www.instagram.com/knuckleheadspodcast/?hl=en Follow on Facebook: https://www.facebook.com/Knuckleheadspod/ See omnystudio.com/listener for privacy information.

We knew that Week 2 in the ACC would include someone losing to an FCS team....we just didn't know who, when, or how. Well... Florida State lost in excruciatingly painful fashion, and we should really start to question what we thought we knew about them at this time last week. Pittsburgh scored more points than Tennessee did on Saturday, which was good, but their overall performance left a few things to be desired. NC State lost convincingly to an average Mississippi State team, leaving us wondering exactly how that happened. Miami just barely found a way to survive against App State. Boston College won the battle against UMass, but may have lost the war in losing Phil Jurkovec for an extended period following a wrist injury. All of that, plus weekly awards, a couple of listener questions get answered, and MORE! Use promo code "GOACC" for 10% off your first order of premium, great-looking, officially-logo'd Georgia Tech gear at Section103.com! Rate and subscribe on Apple Podcasts and Spotify! Follow us on Twitter and Instagram!

Charlie Sheldon is based in Washington and is the author of Strong Heart, Adrift, and the third book in the series Totem (see links below). Charlie went to Yale University and UMass, where he received a Masters Degree in Wildlife Biology/Resource Management. He worked in the fishing industry for 15 years as a deckhand, mate, skipper, and consultant, then relocated to the Pacific Northwest in 1990 to be near Olympic National Park. He worked at seaports for nearly 30 years as a planner, project manager, and executive. When he retired from seaports in 2012 he returned to sea as a merchant sailor for four years, working on various container and military vessels as Able Bodied Seaman and Bosun. He retired in 2016 to work full time at his writing. Nowadays he hikes in the Olympic National Park whenever he can, cooks for his wife, pesters his grandchildren, and continues to scribble tales. Available on Amazon Strong Heart: https://amzn.to/3hs1iSQ Adrift: https://amzn.to/3C7gJrF Totem: https://amzn.to/3hu346c

The Eastern Insider Podcast is back, and this week's edition is jam-packed with great interviews >Alex Jewell and Greg Steiner open the show with all that you need to know from around athletics, and their breakdown of EMU Football's Week Two matchup with Wisconsin > Chris Creighton takes you inside his office as he preps his team for a bounceback week against UMass > Senior center Mike Van Hoeven tells you why he was wearing a different jersey this past Saturday, and fills you in on how his team plans to attack UMass Sept. 18.

Boston College went in to the UMass game as -39 point favorites, but in the end, UMass battled the Eagles hard. On top of all that, BC starting quarterback Phil Jurkovec left the game after the first drive with a wrist injury. We talk about how that impacted the game, and the incredible performance by the ACC's top backup quarterback, Dennis Grosel. Then we are joined by BC Bulletin's Mitchell Wolfe who talks to us about the offense and the defense. The offense did what it needed to do, rushing the ball for 250 yards against a smaller UMass front seven, but the defense of BC struggled. We look at whether it was a fluke or this is fixable. Full analysis of the game, only on Locked on Boston College! Listen below! Support Us By Supporting Our Sponsors! SweatBlock Get it today for 20% off at SweatBlock.com with promo code LockedOn, or at Amazon and CVS. Built Bar Built Bar is a protein bar that tastes like a candy bar. Go to builtbar.com and use promo code “LOCKED15,” and you'll get 15% off your next order. BetOnline AG There is only 1 place that has you covered and 1 place we trust. Betonline.ag! Sign up today for a free account at betonline.ag and use that promocode: LOCKEDON for your 50% welcome bonus. Rock Auto Amazing selection. Reliably low prices. All the parts your car will ever need. Visit RockAuto.com and tell them Locked On sent you. StatHero StatHero, the FIRST Ever Daily Fantasy Sportsbook that gives the PLAYER the ADVANTAGE. Go to StatHero.com/LockedOn for 300% back on your first play. Learn more about your ad choices. Visit podcastchoices.com/adchoices

The Boston College Eagles sit at 1-0 after a lopsided win against FCS foe Colgate on September 4th. This weekend the difficulty only goes up a little as they take on the UMass Minutemen in Amherst. This isn't to troll UMass, but the program has been in dire straights over the last five years, and the Eagles come in as a -39 point favorite. We are joined by Eric Hoffses to break down the game, and give our predictions for the matchup. In addition we swing around the ACC to talk about the games of the past weekend. Which teams stood out to AJ and Eric? Who disappointed in their opening matchups? And what is going on with the Florida State Seminoles....could they be one of the top teams in the ACC again? Finally, we look at gambling odds in the ACC. Some interesting matchups this weekend including Pitt and Tennessee, Rutgers and Syracuse and Appalachian State vs. Miami. Listen below! Support Us By Supporting Our Sponsors! SweatBlock Get it today for 20% off at SweatBlock.com with promo code LockedOn, or at Amazon and CVS. Built Bar Built Bar is a protein bar that tastes like a candy bar. Go to builtbar.com and use promo code “LOCKED15,” and you'll get 15% off your next order. BetOnline AG There is only 1 place that has you covered and 1 place we trust. Betonline.ag! Sign up today for a free account at betonline.ag and use that promocode: LOCKEDON for your 50% welcome bonus. Rock Auto Amazing selection. Reliably low prices. All the parts your car will ever need. Visit RockAuto.com and tell them Locked On sent you. StatHero StatHero, the FIRST Ever Daily Fantasy Sportsbook that gives the PLAYER the ADVANTAGE. Go to StatHero.com/LockedOn for 300% back on your first play. Learn more about your ad choices. Visit podcastchoices.com/adchoices

#WorcesterWednesday with Mayor Joe Petty - COVID, WPS Leadership Change, UMass Medical. (September 8th, 2021)

You can't go 15 and 0 without 1 and 0, and that's where the Birds sit after the first Saturday of the season. Matt and Matt are back to break down Saturday's Colgate Slaughter, and look ahead to the trip down the Mass Pike to Amherst this weekend. It's a great day to be an Eagle - Get In, Folks!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In this episode of UnScripted: The Cardiac Hill Podcast, Corey Cohen analyzes Pitt's dominant win over UMass and what can be taken from it. He also talks about the perfect start from Pitt Volleyball. Learn more about your ad choices. Visit podcastchoices.com/adchoices

On today's show we are joined by Kwan Williams, a four star commitment from Owings Mills, Maryland. Hear about his decision to play football, his connection with defensive line coach Vince Oghobaase, and where he sees Boston College heading in the next few years. The Eagles have been in need of help on the defensive line, and this recruit could be someone who BC fans talk about for years. Our exclusive interview is one you won't want to miss. In addition we look at three keys to beating UMass football on Saturday. With BC a -39 point favorite at the time of this writing, the odds are favorable for a big BC win, but they have to take care of business. What are those three factors? Listen below. Finally, the Eagles will be wearing their red bandana uniforms on Saturday. We talk about Welles Crowther, the meaning of the bandana, and why it is the right thing to do on the 20th anniversary of 9/11 All of this and more on today's show. Support Us By Supporting Our Sponsors! SweatBlock Get it today for 20% off at SweatBlock.com with promo code LockedOn, or at Amazon and CVS. Built Bar Built Bar is a protein bar that tastes like a candy bar. Go to builtbar.com and use promo code “LOCKED15,” and you'll get 15% off your next order. BetOnline AG There is only 1 place that has you covered and 1 place we trust. Betonline.ag! Sign up today for a free account at betonline.ag and use that promocode: LOCKEDON for your 50% welcome bonus. Rock Auto Amazing selection. Reliably low prices. All the parts your car will ever need. Visit RockAuto.com and tell them Locked On sent you. StatHero StatHero, the FIRST Ever Daily Fantasy Sportsbook that gives the PLAYER the ADVANTAGE. Go to StatHero.com/LockedOn for 300% back on your first play. Learn more about your ad choices. Visit podcastchoices.com/adchoices

Today on Boston Public Radio: Art Caplan talks about the Supreme Court's upholding of the new Texas abortion law and an Ohio judge protecting hospital patients from the latest controversial and off-label COVID-19 treatment — the anti-parasitic drug ivermectin. He also weighs in on conflicting attitudes surrounding vaccine booster shots. Caplan is the Drs. William F. and Virginia Connolly Mitty Professor and founding head of the Division of Medical Ethics at NYU School of Medicine in New York City. Then, we hear listeners' opinions on boycotting business that have not spoken out against the new Texas abortion law. Andrew Bacevich weighs in on who should take responsibility for the crisis in Afghanistan, the United States' standing in the world 20 years after 9/11 and what service to the country should look like. Bacevich is the President of the Quincy Institute for Responsible Statecraft, a Professor Emeritus of International Relations and History at Boston University and author of "The Age of Illusions: How America Squandered Its Cold War Victory.” State Rep. Mike Connolly discusses his bill looking into reversing the state's Happy Hour ban, which he hopes could help restaurants bounce back from COVID-19. Connolly represents the Massachusetts House of Representatives' 26th Middlesex district, which comprises East Cambridge and East Somerville. Laura Sullivan shares insights from her reporting on the Red Cross' work in Haiti, and how the organization only built six homes in the country after raising half a billion dollars following the 2010 earthquake. She also talks about how to best support people in Haiti by donating to local organizations. Sullivan is an investigative correspondent for NPR who reported extensively on the Red Cross in 2015. Shirley Leung gives an update on the latest business headlines, including business leaders' opinions on the mayor's race, and a 50 million dollar donation from the Manning family to the UMass system. She also discusses how requesting housekeeping at hotels can keep staff employed. Leung is a business columnist for The Boston Globe and a GBH contributor. Then, we talk with listeners about the current coin shortage and the challenges of parking and paying for laundry.

Tatum Hackenberg (maiden name Coffey) played lacrosse at Penn State University from 2012-2015 where she was a 2-time All-American, then played professionally in the United Women's Lacrosse League for the Long Island Sound, and now is a coach and trainer for 3 Point Lacrosse.  She talks about growing up in Toms River, playing  soccer, basketball, and boys hockey, and not playing lacrosse until she was a Freshman in high school.  She describes her great career at Toms River North High School where she earned 12 varsity letters, scored over 300 goals in lacrosse, was 1st team All-American, and was the MVP of the Under Armor All-American game.  Tatum discusses her recruiting process, originally picking UMass,  and how she ended up at Penn State.  She then talks about her phenomenal career with the Nittany Lions, winning a Big Ten Conference Championship, making the NCAA Tournament twice,  being a 2-time All American,  meeting her now husband Christian, the former Penn State and NFL Quarterback, and how they made the relationship work through busy schedules and long distance.  Tatum explains her time as a sideline reporter in college, playing professionally for the Long Island Sound, and her goal to grow the game of lacrosse in the Toms River area through training and coaching at 3 Point Lacrosse.

The Boston College Eagles and UMass Minutemen face off in Amherst for the first time since the 1980's. Expectations are high for Jeff Hafley and his squad, after thrashing Colgate 51-0 at Alumni Stadium. UMass on the other hand is struggling, losing badly to Pitt in week one. We are joined by Michael Traini of Fight Massachusetts to talk about the Minutemen, Walt Bell and the Hanger. In addition we talk about the news, and the exciting announcement by four star guard Donald Hand Jr. who pledged to Boston College on Tuesday. We look at Earl Grant's first '22 commitment, and why this step was a big one. Support Us By Supporting Our Sponsors! SweatBlock Get it today for 20% off at SweatBlock.com with promo code LockedOn, or at Amazon and CVS. Built Bar Built Bar is a protein bar that tastes like a candy bar. Go to builtbar.com and use promo code “LOCKED15,” and you'll get 15% off your next order. BetOnline AG There is only 1 place that has you covered and 1 place we trust. Betonline.ag! Sign up today for a free account at betonline.ag and use that promocode: LOCKEDON for your 50% welcome bonus. Rock Auto Amazing selection. Reliably low prices. All the parts your car will ever need. Visit RockAuto.com and tell them Locked On sent you. StatHero StatHero, the FIRST Ever Daily Fantasy Sportsbook that gives the PLAYER the ADVANTAGE. Go to StatHero.com/LockedOn for 300% back on your first play. Learn more about your ad choices. Visit podcastchoices.com/adchoices

He's back! Scott Mutryn is back on the podcast. The former BC QB and Learfield IMG sideline reporter for the Eagles talks with Mike about BC's dominating win over Colgate. We break down all parts of the game with a focus on QB Phil Jurkovec. Plus, how will the Eagles prepare for UMass out in Amherst? All that and more. To advertise on the podcast, please email mike@lightscamerasports.com

After Pitt's 51-7 win over UMass on Saturday, we went live for a post-game reaction show to talk about the blowout, the tight ends, the running backs, the defense and a lot more. 

This episode features Neil Gilchrist, Chief Pharmacy Officer of UMass Memorial Health. Here, he discusses workforce development, the continued shift to value and outcomes based services, and more.

Coach Duzz joins us ahead of tomorrow's season opener against UMass. Hear what he says about the season expectations, his roster, the preseason rankings in the ACC and more!  See omnystudio.com/listener for privacy information.

EdUp Exclusive with YOUR sponsor MDT Marketing! Before you read about UMass acquiring Brandman University, The EdUp Experience was talking about it with Don Kilburn, CEO of UMass Online! Welcome back to America's leading higher education podcast! In this episode, EdUp got the scoop on how and why UMass and Brandman went from exploring a partnership to birthing UMass Global. UMass Global will serve online working adult students by offering them online programs with wraparound services for that particular market. Through strategic positioning, UMass Global now has a coast-to-coast profile to expand its geographic footprint. Donald C. Kilburn is currently the CEO of UMass Online. He is a pioneer and expert in online education with nearly three decades of experience developing innovative education solutions and a track record of developing successful growth strategies for high impact organizations. Prior to this role, Mr. Kilburn served as the President of Pearson North America – the largest education company in the world – managing over $4 billion in sales and 15,000 employees. He also served as CEO of Pearson Learning Solutions and Vice Chairman of Higher Education. From 1998 until 2008, he served as President of Pearson Custom Publishing with responsibility for overseeing its higher education services and solutions business. Before joining Pearson, Mr. Kilburn spent 12 years at Simon and Schuster Custom Publishing during which he served as editor-in-chief for six years, and then later as President of the business for six years. He also worked for the Xerox Corporation and served as a Director of Interactive Data Corporation. Another awesome episode with your sponsor MDT Marketing! Get your free marketing consultation today! mdtmarketing.com/edup Thank you so much for tuning in. Join us on the next episode for your EdUp time! Connect with your hosts - Elvin Freytes, Elizabeth Leiba, and Dr. Joe Sallustio ● If you want to get involved, leave us a comment or rate us on Apple Podcasts! ● Join the EdUp community at The EdUp Experience! ● Follow us on Facebook | Instagram | LinkedIn | Twitter | YouTube Thanks for listening! We make education your business!

It's finally football season with real games to talk about! Dan and Emily break down this week's AAC games, including the difficult situation that Tulane is navigating in the wake of Hurricane Ida. Plus, accidental UMass football coverage.  Learn more about your ad choices. Visit podcastchoices.com/adchoices

Episode 85 of The Latke Room, your favorite jews talk about Henrik a Lundqvist and the new Spider-Man trailer. Then Mollie Walker, a Sports Reporter for the New York Post (26:14) joins the show to talk about her journey working in sports and trending topics around the NHL.

The Rangers lost one of the greatest players in team history "Mr. Ranger" and Hockey Hall of Famer Rod Gilbert. The hockey world also mourns the loss of former NY Rangers player Kevin Hayes' brother Jimmy who passed away unexpectantly at 31 years old. The King, Henrik Lundqvist announced his retirement this past weekend and the Rangers also announced they will be retiring this number 30 this season. The Rangers also announced their full coaching staff for the upcoming season. This week our guest is former New York Rangers defenseman Thomas Poeck. Thomas played 4 seasons with the Rangers and another for the Islanders. He also was the first Hobey Baker finalist for UMass Hockey. Thomas shared some great stories that you don't want to miss.

We caught up with Ferraro, one of the best young defensemen in the league and the future of the Sharks' blueline. We talked about his journey to the NHL, his time in UMass, being partners with Burnzy, and what to expect from the Sharks this year.

Is this the year Oklahoma finally puts it all together and wins a national championship? Can Oklahoma State's offense get its act together? Which direction is West Virginia headed? How does Kansas State defy the laws of college football physics? And, oh no, that Kansas schedule. Ty and Dan conclude their preview of the Big 12 and also investigate BYU, New Mexico State, and UMass before taking a closer look Conference USA East.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.