Podcast appearances and mentions of Jennifer A Doudna

Tijeras a nivel molecular serían la vía para curar el VIH. Científicos de la Universidad de Amsterdam presentaron avances de una investigación basada en la técnica conocida como Repeticiones Palindrómicas Cortas Agrupadas y Regularmente Espaciadas (CRISPR, por sus siglas en inglés), la cual fue inventada por los ganadores del premio Nobel de Química 2020, Emmanuelle Charpentier y Jennifer A. Doudna… dicha investigación apunta a poder eliminar con éxito el VIH de las células, lo cual es un completo avance, ya que, hasta el momento, el virus sólo puede detenerse. Esto apenas está en desarrollo, pero ya comienza a asomarse.

How have microbes changed the course of life on our planet? How has our atmosphere changed as a result of bacteria and archaea? Assimilation can help enhance single cellular life. Archaea can collect long strings of extra genes just in case. Finding the right gene at the right moment can help Archaea make the most of available food. Basem Al-Shayeb, Marie C. Schoelmerich, Jacob West-Roberts, Luis E. Valentin-Alvarado, Rohan Sachdeva, Susan Mullen, Alexander Crits-Christoph, Michael J. Wilkins, Kenneth H. Williams, Jennifer A. Doudna, Jillian F. Banfield. Borgs are giant genetic elements with potential to expand metabolic capacity. Nature, 2022; DOI: 10.1038/s41586-022-05256-1

Ki ne szeretne megjavítani magán egy-két dolgot? Például magasabb vagy alacsonyabb lenni egy picit, esetleg felturbózni a nyelvérzékét és a memóriáját. Milyen lenne egy tökéletesre tenyésztett társadalom betegségek nélkül? Ezt a jövőt akarjuk? Nagy Ildi és Baranyi Marci Varga Mátéval, az ELTE Genetikai Tanszékének oktatójával és kutatójával beszélget a génszerkesztés jelenéről, jövőjéről és etikai kérdéseiről az Ott vagyunk már? legújabb epizódjában.    Ez itt az Index.hu és a Brain Bar közös podcastsorozata, ahol azt vizsgáljuk, milyen jövőt ígért a tudomány és mikor valósulnak meg a jóslatai. A beszélgetést a Porsche Centrum Budapest támogatta.     (00:00) A kasztszerű embertenyésztés a világbéke záloga?  (00:56) Politikai biológia, avagy milyen célja lehet az ember tudatos tenyésztésének?  (04:30) A génjeink határoznak meg minket? És ha igen, mit hozhat el számunkra a génmódosítás?  (10:41) Génszerkesztéssel kiirthatóak a halálos betegségek?  (11:44) Varga Máté, az ELTE Genetikai Tanszékének oktatója és kutatója csatlakozik a beszélgetéshez  (19:24) Milyen betegségeket tudunk már megelőzni génszerkesztéssel?  (23:40) Hol lehet elvágni egy DNS szálat?  (29:30) Miért kellenek halak a génszerkesztéshez?  (32:15) Hol a határ növénynemesítés és génmódosítás esetén?  (39:27) GMO-val a klímaváltozás ellen?  (40:48) Egyre törékenyebb lesz a világ a génszerkesztéssel?  (42:08) Az első génmódosított ikerpár története és a génszerkesztés etika-kódexe  (49:27) Mikor jön el a dizájner bébik kora?  Podcast  Hallgasd meg a Könyvpárbaj legutóbbi epizódját, amelyben Jennifer A. Doudna, a génszerkesztés egyik legfontosabb alakjának könyve alapján Ildi és Marci a terület etikai vonatkozásait vitatja meg: https://spoti.fi/3vurMKQ     Filmek  Mary Shelley's Frankenstein: https://imdb.to/3lFCUik  Human Nature – Jennifer A. Doudna szereplésével: https://imdb.to/3GawCRr  Rampagne: https://imdb.to/3sRQB1I    Könyvek  Aldous Huxley - Szép új világ: https://bit.ly/38M56gL   Mary Shelley – Frankenstein, avagy a modern prométheusz: https://bit.ly/3wK9i8O  Jennifer A. Doudna - Samuel H. Sternberg - Meghekkelt teremtés - Hogyan irányíthatjuk a génszerkesztéssel az evolúciót?: https://bit.ly/38y5tuT  Henry T. Greely - CRISPR People: The Science and Ethics of Editing Human: https://bit.ly/3LAK429       Extrák   Varga Máté kutatócsoportjának honlapja: http://danio.elte.hu/   Eugenika – az eszme a holokauszt mögött: https://bit.ly/3wHPoMP   Különbség vagy betegség? Ki mondja meg? https://bit.ly/3PGcevB   Mit jelent a “nature or nurture”? https://bit.ly/3lLbQy9   Hogy fejlődött ki a mai görögdinnye? https://bit.ly/3yVZ2gu   Hogy néztek ki a gyümölcsök régen? https://bit.ly/3wEStwZ   Mi az a CRISPR? https://bit.ly/39TI3B2   Lulu és Nana – kiszivárgott a hír a világ első génmódosított babáiról: https://bit.ly/3LIEoD6   Lulu, Nana és a génmódosítás etikai dilemmái: https://bit.ly/3wKZmMn  

Quade is one of 36 Kid Reporters in Scholastic Kids Press. He is 12 years old, in 7th grade, and lives in Encinitas, CA. This is Quade's 2nd year in the Scholastic Kids Press program. He has interviewed Olympic athletes, and covered stories including biochemist Jennifer A. Doudna and microbiologist Emmanuelle Charpentier receiving Nobel Prizes, and the SpaceX Crew Dragon heading to the International Space Station.Link to online Kid Reporter bio: https://kpcnotebook.scholastic.com/user/374

A partir de la arquitectura que imita las formas naturales o del CRISR, que ha revolucionado la edición genética, reflexionamos sobre la compleja relación entre la ciencia, la tecnología y la naturaleza en el siglo XXI. AUTORES CITADOS: Leonardo Da Vinci, Antoni Gaudí, Jorge Wagensberg, Carl Sagan, John Berger, Jennifer A. Doudna, Samuel H. Sternberg, George Basalla, Jussi Parikka, Francisco Mogica, Tomás Libertiny, David Benjamin, Neri Oxman, Janine Benyus, William McDonough, Nicolas Bourriaud, Tomás Saraceno. Para seguir leyendo: La rebelión de las formas o cómo preservar cuando la incertidumbre aprieta, de Jorge Wagensberg (Tusquets). Una grieta en la creación: CRISPR, la edición génica y el increíble poder de controlar la evolución,  de Jennifer A. Doudna y Samuel H. Sternberg (Alianza Editorial). The Evolution of Technology, de George Basalla (Cambridge University Press). Insect Media: An Archaeology of Animals and Technology, de Jussi Parikka (University of Minnesota Press).

Algumas delas dedicaram toda as suas vidas em prol de produzir a ciência que nos salva. Neste episódio, os professores Marquinhos e Geison receberam a nossa querida Dra. Alexsandra Valério para gravar o quarto episódio da série sobre as "Mulheres na Ciência". Eles falaram um pouco sobre as fantásticas "Lise Meitner", a cientista que descobriu a fissão nuclear; "Katherine Johnson", que tinha mais credibilidade que os computadores da NASA e foi fundamental para o envio dos primeiros astronautas americanos para o espaço; "Emmanuelle Charpentier" e "Jennifer A. Doudna" as cientistas que descobriram um método de edição genética. Embarque conosco nessa jornada que tem o objetivo de resgatar as grandes descobertas científicas realizadas por mulheres! Vem Cienciar conosco e Um Feliz dia das Trabalhadoras!

We chat to Debra about the merging of media, retail and entertainment in the fashion industry, ‘squad shopping', the complexities of sustainability in the sector and Andrew tries to pitch his own fashion label!Find out more about DebraWatch: My Octopus TeacherRead: A Crack in Creation: Gene Editing and the Unthinkable Power to Control Evolution, Jennifer A Doudna & Samuel H SternbergListen: Scott Galloway

Gayathri Vijayakumar is a virologist at Scribe Therapeutics, the start-up firm co-founded by Nobel laureate Jennifer A Doudna to develop gene-editing technique CRISPR.

Who said academics can't be entrepreneurs? Benjamin L. Oakes is the Founder and CEO of Scribe Therapeutics, a company rewriting the story of disease and engineering the future of genetic medicine. Completing his PhD at University of California, Berkeley in 2017 - Oakes worked under the supervision of Jennifer A. Doudna, a 2020 Nobel prize winner. In this podcast, we explore Oakes' career path & and the practical application of his research to make huge advancements in the field.

El doctor Marcelo Cortez, profesor del Laboratorio de Virología Molecular y Control de Patógenos de la Facultad de Química y Biología de la USACH, explica de qué se trata la técnica CRISPR/CAS9 que convirtió a Emmanuelle Charpentier y Jennifer A. Doudna en merecedoras del reconocimiento.Conduce: Patricia de la Parra

dessanをゲストに迎え、CRISPRの仕組みを利用した様々な技術や遺伝子回路、これからの発展について話しました。Show notes The Nobel Prize in Chemistry 2020…The Nobel Prize in Chemistry 2020 was awarded jointly to Emmanuelle Charpentier and Jennifer A. Doudna “for the development of a method for genome editing.” Scientifc Background on the Nobel Prize in Chemistry 2020 A TOOL FOR GENOME EDITING…ノーベル財団による詳細なCRISPR研究のレビュー、そしてなぜDoudnaとCharpentierの二人が受賞に値するのかについて説明している。 76. The Chimeric RNA, Researchat.fm…ゲノム編集についてdessanをゲストに迎えて話しました。 A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity. Science 2012…CharpentierとDoudnaによるノーベル賞につながる論文の一つ。CRISPR–Cas9システムがこの論文によってその大枠が明らかにされた。 Multiplex Genome Engineering Using CRISPR/Cas Systems. Science 2013…Feng Zhang labによるヒト細胞におけるゲノム編集技術の報告。 RNA-Guided Human Genome Engineering via Cas9. Science 2012…George Church labによるヒト細胞におけるゲノム編集技術の報告も同時に掲載された。 First rounders: Feng Zhang (Podcast)…Feng Zhangが出演したNatute Biotechnologyのポッドキャスト。おすすめです。 26. Cool tech googlability, Researchat.fm…RNAを標的にできるCas13bについては、エピソード26で紹介しました。 Cas14 (crisp_bio)…“Cas14は、PAMに依存しないssDNA切断活性に加えて、PAMに依存するdsDNA切断活性も帯びている” CasX enzymes comprise a distinct family of RNA-guided genome editors. Nature 2019…CasX Transposon-encoded CRISPR–Cas systems direct RNA-guided DNA integration. Nature 2019…トランスポゾン型のCasシステムの報告。 RNA-programmed genome editing in human cells. eLife 2013…Doudna labによるヒト細胞におけるゲノム編集技術の報告。FengやChurchらよりも少しだけ遅かった。 Microhomology-mediated end-joining-dependent integration of donor DNA in cells and animals using TALENs and CRISPR/Cas9. Nature Communications 2014 Ep52. Split into a row Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity. Cell 2013…Double nicking (2つのgRNAとCas9 nickase)によるより正確なゲノム編集方法が示された。 Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex. Nature 2015…Cas9を用いた転写の活性化手法。 Live visualization of chromatin dynamics with fluorescent TALEs. Nature Structural & Molecular Biology 2013 … TALENを用いた染色体の特定領域のイメージング方法 Dynamic Imaging of Genomic Loci in Living Human Cells by an Optimized CRISPR/Cas System. Cell 2013…dCas9-EGFPによる生細胞のイメージング技術。SpCas9の場合は、D10AとH840Aの２つの変異を入れることで、DNAに結合するが切断しないdead Cas9 (dCas9)として利用することができる。 Live cell imaging of low- and non-repetitive chromosome loci using CRISPR-Cas9. Nature Communications 2017…ガイドRNAにMS2 loopをたくさんつなげることで (14個!)、明るい輝点を得ることができる。 CRISPR-mediated live imaging of genome editing and transcription. Science 2019…こちらは蛍光標識したガイドRNAを利用した生細胞イメージング方法。 A protein tagging system for signal amplification in gene expression and fluorescence imaging. Cell 2014…Sun tagとCas9を用いたイメージング方法。 Split Green Fluorescent Proteins: Scope, Limitations, and Outlook…Split GFP Programmable RNA tracking in Live Cells with CRISPR/Cas9. Cell 2016…PAMmerによるSpCas9のmRNAイメージング CRISPR-Mediated Programmable 3D Genome Positioning and Nuclear Organization. Cell 2018 … CRISPR-GO：CRISPR技術、核内でのゲノム空間構造、ポッドキャスト内ではゲノム同士を寄せるという説明をしていましたが、今調べてみると特定のゲノム領域と核膜やカハール体への再配置ということでした。 Manipulation of nuclear architecture through CRISPR-mediated chromosomal looping. Nature Communications 2017 … こちらがCRISPRの仕組みを用いることで人工的に染色体内部にループを作成した論文。 Transcriptional repression mediated by repositioning of genes to the nuclear lamina. Nature 2008 … LacO-LacIの仕組みを用いることでゲノムの特定領域にLacO arrayを差し込み、核膜に局在させたLacIに結合させることである遺伝子領域を核膜側に誘導しようとした論文。最初にこの論文を読んだ時はそのアイデアにたまげました。 9. One-shot beautiful experiment (Researchat.fm)…人工的なDNA領域へ細胞内の情報（細胞系譜）を書き込む技術についてエピソード9で話しました。 CRISPR–Cas encoding of a digital movie into the genomes of a population of living bacteria. Nature 2017…George Churchらは、Cas1-Cas2システムによって馬の動画をバクテリアゲノム書き込み、それを読み出すことに成功した。 Multiplex recording of cellular events over time on CRISPR biological tape. Science 2017…コピー数の異なる2つのプラスミドをCas1-Cas2で取り込ませて、細胞内で人工的な時計のような仕組みを実現した。 Single-Nucleotide-Resolution Computing and Memory in Living Cells. Molecular Cell 2019…Tim Liu Labによる複雑な遺伝子回路の実現。DOMINOについては、プロモーター配列を標的にしているのではなくオペレーター配列でした。 Rewritable multi-event analog recording in bacterial and mammalian cells. Science 2018…David Liu labから報告されたガイドRNAによって連鎖する遺伝子回路（カスケード）の実現。 Terminal Deoxynucleotidyl Transferase, TdT…テンプレートに依存しないDNA合成を可能にする酵素。 Tandem fluorescent protein timers for in vivo analysis of protein dynamics. Nature Biotechnology 2012…GFP Timer Permanent genetic memory with >1-byte capacity. Nature Methods 2014 Continuous genetic recording with self-targeting CRISPR-Cas in human cells. Science 2016…自分で自分のガイドRNAを編集することで、理論的には無限に情報を書き込む方法が提案されたが、領域が壊れてしまう問題もある。 Ten Simple Rules to Win a Nobel Prize. ヘンリー・ブラッグ (Wikipedia) iPS細胞 (Wikipedia) 国境なき医師団 Human Genome Project Xiaowei Zhuang Expansion microscopy (Wikipedia) Renato Dulbecco (Wikipedia) Programmable RNA editing by recruiting endogenous ADAR using engineered RNAs. Nature Biotechnology 2019…LEAPER crisp_bio … 世界広しといえでも、これだけCRISPRの最新情報がまとまっているサイトはCRISP_BIOさんの他に世の中には存在しません。日本語でCRISPRの最先端情報を追える喜び。CRISP_BIOさん、いつもありがとうございます。 Editorial notes 1分でわかるとか無理なのですが、一方で言葉を尽くせばわかる可能性についても同時に信じておりますので…(soh) 思い出しながらどんどん話しているので、後から聞き返すと細部が間違っていたりしています。気になった方はshow notesをご参照ください。(dessan) いい感じのグルーヴがみられてよかったです。ポッドキャストやってきてよかったです。(tadasu) 最初に喋らんと出番が無くなる！と思ってこれまでの流れをまとめてみたんですが細かく色々ミスってました…(coela)

Nobel ödüllerini belirleyen enstitülerden biri olan İsveç’teki Karolinska Enstitüsü’nden Erdinç Sezgin, ödülün 1901’den bugüne kadar ki hikayesini Kısa Dalga’dan Kemal Göktaş’a anlatıyor.“Ödülün adı Alfred Nobel'den geliyor. Dinamiti bulan ve kimya alanında birçok buluşa imza atan birisi. Alfred Nobel’in kardeşi (Ludving) ölüyor. Fransız bir gazete bunu Alfred Nobel ölmüş gibi algılıyor ve “Milyonların ölmesine sebep olan buluşu yapan Alfred Nobel öldü” diye manşetine taşıyor. Alfred Nobel bunu görünce yıkılıyor tabii. Ölümünden önce de böyle bir vasiyette bulunuyor, “ben öldükten sonra adıma bir ödül verilsin” diye…”Nobel Kimya Ödülü’nü bu yıl iki bilim kadını aldı: Emmanuelle Charpentier ve Jennifer A. Doudna. İki kadının aralarında kanserin de olduğu hastalıklara çare olan buluşu nasıl davalık oldu. İki bilim kadının Nobel zaferinin perde arkası.•Nobel ödülleri bugüne kadar kişilere verildi, bundan sonra bilimsel çalışma yapan gruplar mı alacak? •Bilimsel çalışmalara katılan doktora öğrencilerinin hakkı mı yeniyor?•Bu yılki ödüllerin insanlık tarihi için önemi ne?•Nobel’i önemli hale getiren “duygusal” nedenler•Albert Einstein Nobel ödülü parasını kime bıraktı?•Sartre ve Nobel ödülünü reddeden üç kişi•Nobel Kimya ödülünü alanların yaptığı büyük devrim •Nobel ödülleri neden takımlara değil de kişilere veriliyor? •Coğrafya, Nobel ödüllerinde de mi kader?

This year's Nobel Prize in Chemistry was awarded for the discovery of the CRISPR/Cas9 gene editing system.   The prize was shared by Emmanuelle Charpentier, a microbiologist and director of the Berlin-based Max Planck Unit for the Science of Pathogens, and Jennifer A. Doudna, a professor and biochemist at the University of California, Berkeley. #crispr #CRISPracing #crisprcas9 #crisprosperi #genetics #genetica #genetic #geneticallymodified #genetictesting #GENETICFREAK #geneticlab #GeneticPassport #geneticdisorder #geneticmorph #geneticallyengineered #GeneticEngineering #geneticallygifted #geneticallymodifiedorganism #geneticMEMORY #geneticsupps #genetictrainer #geneticallymodifiedorganisms #GeneticallyModifiedFood #geneticallysuperior #geneticmutation #geneticopera #geneticallyalteredfood #geneticista #geneticcounselling #geneticmodification

dessanをゲストに迎え、CRISPR–Cas9やTALENなどのゲノム編集技術とその背後にある遺伝学について話しました。Show notes The Nobel Prize in Chemistry 2020…The Nobel Prize in Chemistry 2020 was awarded jointly to Emmanuelle Charpentier and Jennifer A. Doudna “for the development of a method for genome editing.” Scientifc Background on the Nobel Prize in Chemistry 2020 A TOOL FOR GENOME EDITING…ノーベル財団による詳細なCRISPR研究のレビュー、そしてなぜDoudnaとCharpentierの二人が受賞に値するのかについて説明している。 Emmanuelle Charpentier…DoudnaとCharpentierは2011年に学会で知り合い、そこからノーベル賞につながる共同研究を開始した。 Jennifer Doudna…CharpentierとともにCRISPRの仕組みを明らかにし、その後のゲノム編集そしてCasタンパクを用いた核酸検出など多大な貢献をした。 2. An emerging technology is always not perfect…始まって間もない第二回でもざっくりとCRISPR–Cas9について解説しました。 dessanが出た過去回のResearchat.fmのエピソード…ep37, ep38, ep51, ep58 37. Biological Enigma … 今回のep67はep37の続編という位置付けなので、分子細胞生物学に興味がある方はep37を聴いてからep76を聴いていただけるとより理解が深まります。 ゲノム編集とはなにか　「ＤＮＡのハサミ」クリスパーで生命科学はどう変わるのか (ブルーバックス) (Amazon) 遺伝学 (Wikipedia) 遺伝学的スクリーニング…逆遺伝学と順遺伝学について。 トランスジェニック動物 表現型 (Wikipedia) Thomas Hunt Morgan (Wikipedia) 遺伝子の必須性は細胞の進化可能性にリンクした定量的特性である…必須遺伝子などについて Cell type (Wikipedia)…日本語ではセルタイプあるいは細胞種 部位特異的ヌクレアーゼを基盤とするゲノム編集技術…ZFNやFok1などについての山本先生らによる日本語解説論文。 72. The Hitchhiker’s Guide to the Enzyme Galaxy…エピソード72では制限酵素の多様な世界について紹介しています。 TALEN (Wikipedia) Golden Gate Assembly法…Type IISと呼ばれる制限酵素を用いることで、複数のDNA断片を一度に連結させることのできるクローニング技術。 ガイドRNA…guide RNAあるいはsingle-guide RNAとも呼ばれるcrRNAとtracrRNAを一つのRNAとして連結させたRNA分子。 crRNA…CRISPR RNA tracrRNA…trans-activating crRNA A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity. Jinek et al Science 2012.…ノーベル賞の受賞に直接的に関連するDoudnaとCharpentierらによる論文。この仕事によってCas9によるゲノム編集の仕組みの大枠が解明された。 Ribozyme (Wikipedia) Argonaute (Ago) Editorial notes 実はdessanと初めて話しました。そしてまだ対面では会ったことはないのちょっと面白くないですか？(soh) ノーベルのおかげで、急遽参加させていただきました！(dessan) ~亜米利加男塾~ 王TALEN 「切断確認」という冗談はさておき、リトアニアのVirginijus Siksnys先生についても話したかったですね。(tadasu) dessan相変わらずの分かりやすさでした！何かに例える事のいい側面と失われる情報の側面が悩ましい。(coela)

In news from our slow slide into autocracy, six militia members were arrested and charged with planning to kidnap Michigan Governor Gretchen Whitmer. They planned to try her for treason in a kangaroo court. The penalty for treason, of course, is death. The plot included attempts to recruit 200 armed men to storm the Capitol building in Lansing and taking hostages, including Gov. Whitmer. An additional seven men affiliated with the extremist group, “Wolverine Watchmen” were also arrested for threatening to “start a civil war leading to societal collapse.” Can’t make this shit up.  The militia plot is just one more stark example of how Trump and the Republican party have fanned the flames of white supremacy and wannabe fascists. Last week Trump called on the Proud Boy fascists to “stand back and stand by.” When right-wing protesters, many of them heavily armed, descended on the Michigan Capitol back in April and May, Trump tweeted the encouraging words: “LIBERATE MICHIGAN.”  Get used to it, I guess. Turns out up until 2017 the Republican National party was restricted from using “poll monitors” because of a campaign of voter intimidation in New Jersey.  Yes, the fly was the star of the Vice Presidential debate on Wednesday.  Oh, yeah, Trump is flying high on steroids and looking to give all his Big Pharma pals a taste of the action as he hocks Regeneron’s antibody treatment REGN-COV2. Meanwhile the White House super-spreader event in the Rose Garden marches on.  EPA grants Oklahoma control over Tribal Lands so they can be further exploited. This strips from 38 tribes in Oklahoma their sovereignty over environmental issues. It also establishes a legal and administrative pathway to potential environmental abuses on tribal land, including dumping hazardous chemicals like carcinogenic PCBs and petroleum spills, with no legal recourse by the tribes, according to a former high-level official of the EPA. Senator Pat Toomey announced on Monday that he will not be running for reelection in 2022 nor will he be running for Governor, which leaves the door wide open for Q-Anon conspiracy theorists like Doug Mastriano to take the nomination.  This opened a ton of speculation as to which progressives are looking to run. Names already include Helen Gym and Summer Lee.  Unions are “all in” for Republican Brian Fitzpatrick in Bucks County, once again relying on a strategy to court more moderate Republicans instead of build power on the left.  PA Stands Up and other progressive groups get the shout out in Vanity Fair for organizing independently of the Biden campaign that seems more interested in increasing the percentage of white conservative Democratic men who voted for Trump in 2016, than expanding the electorate and getting out the vote in strong Democratic areas. Helen Gym the progressive, populist city council member in Philly, told the magazine, “It doesn’t matter what the Biden campaign is doing—groups are mobilizing on the left, and statewide they’re united as PA Stands Up...Many of these groups are absolutely ignored by both parties, but we’re moving at the local level, and we’re making hundreds of thousands of phone calls across the state. We have proven to be very effective at winning at the margins.” The Nobel Prize in Chemistry went to Emmanuelle Charpentier and Jennifer A. Doudna for the development of the CRISPR/Cas9 genetic scissors. CRISPR makes it possible to snip out very precise segments of genetic code which has revolutionized molecular life sciences and contributed to promising therapies for cancer and inherited diseases. This is the first time two women jointly won the Nobel Prize in Chemistry, and the 6th and 7th women to win the prize.  It’s almost here! Season 3 of Star Trek Discovery returns to CBS All Access next Thursday, October 15th. The opening scene was released this week. It looks like it’s going to be a hell of a season.  Kevin just got another shipment from Levante Brewing and Free Will Brewing is getting ready to release this year's Sharing Size. So awesome. 

TGIF! We're talking light therapy helping seniors get better sleep and congratulating chemists Emmanuelle Charpentier and Jennifer A. Doudna on being the first two women to share the Nobel Prize. Listen to The Optimist Daily Update with Summers & Kristy - Making Solutions the News!

I dagens avsnitt bland annat: Omvärlden reagerar på konflikten om Nagorno-Karabach, Donald Trump friskförklarad, Synsam flyttar tillbaka tillverkningen från Kina till Sverige, gensaxen CRISPR/Cas9, svarta hål och amerikansk poesi bland årets nobelprisvinnare samt dansk forskningsrapport förklarar svenska dödsfallen från Wuhansjukan https://radio.bubb.la/torsdag-8-oktober-2020/ Länkar som diskuterades i dagens sändning: Förband ur den av Turkiet stödda nationella Syriska nationella armén strider nu på Azerbajdzjans sida i kriget mot Armenien om kontroll över Nagorno-Karabach, styrkorna har tidigare också opererat som Turkiets legosoldater under inbördeskriget i Libyen Friskförklarad Donald Trump skrivs ut från militärsjukhuset Walter Reed och ses posera på Vita husets balkong, tar rakryggad och med triumfatorisk hållning av sig ansiktsmasken under vad som av MSNBC beskrivs som ett “Mussolini moment”, CNN målar upp situationen som något som hör hemma i totalitära Nordkorea Glasögontillverkaren Synsam flyttar produktionen från Kina till Ockelbo, bygger ny fabrik som ska producera en miljon glasögon årligen, orsakerna till flytten är Ockelbos historia av entreprenörskap, läget samt klimatet, satsningen ger inledningsvis 150 nya arbetstillfällen Nobelpriset i litteratur 2020 till amerikanska poeten Louise Glück för hennes sökande efter det allmänmänskliga med hjälp av antika myter och klassiska motiv och för en förmåga att förena det personliga med det universella Nobelpriset i kemi tilldelas Emmanuelle Charpentier och Jennifer A. Doudna för utvecklingen av gensaxen CRISPR/Cas9, som inte bara revolutionerat grundvetenskapen utan även växtförädlingen och kommer att leda till nya medicinska behandlingar Nobelpriset i fysik delas ut till Roger Penrose för upptäckten att bildandet av svarta hål är en konsekvens av den allmänna relativitetsteorin och till Reinhard Genzel och Andrea Ghez för upptäckten av ett supermassivt kompakt objekt i Vintergatans centrum Folkhälsomyndigheten hävdar svenskar blivit för slappa och förklarar att nuvarande coronarestriktioner kommer ligga kvar minst ett år, generaldirektör Johan Carlson skönjer viss trötthet hos människor, men tycker sig inte se vrede och aggression likt i övriga Europa, flaggar för lokala restriktionspaket som innebär begränsning av kollektivtrafik och förbud mot att befinna sig i affärer om det inte handlar om att handla mat Working Paper: Exceptionally Many Vulnerable – ‘Dry Tinder' – in Sweden Prior to COVID-19

Le Prix Nobel de chimie est décerné à deux généticiennes, la Française Emmanuelle Charpentier et l'Américaine Jennifer A. Doudna pour leurs travaux sur le ciseau génétique CRISPR-Cas9. Cette découverte biomédicale permet de couper un gène précis. Avec Didier Trono, responsable du laboratoire de virologie et génétique de lʹÉcole polytechnique fédérale de Lausanne (EPFL). Un sujet de Stéphane Délétroz.

Es klingt verlockend, was mit der Genschere Crispr/Cas9 alles möglich sein könnte: Innovative Krebstherapien, man könnte Erbkrankheiten möglicherweise heilen und die DNA von Menschen, Tieren, Pflanzen und Mikroorganismen verändern. Die beiden Forscherinnen, die diese Methode entwickelt haben, Emmanuelle Charpentier und Jennifer A. Doudna, wurden dafür heute mit dem Chemie-Nobelpreis geehrt. 2012 gelang ihnen mit einer grundlegenden Forschung der Durchbruch. Der Mechanismus ist günstig und effizient und der Mensch könnte sich die Welt damit theoretisch selbst modellieren. Deshalb ist er auch hoch umstritten. Linda Fischer aus dem Wissensressort ordnet die Vergabe des Preises ein und erklärt das Revolutionäre an der Crispr/Cas9-Methode. Wer darf wie wo in Deutschland Urlaub machen? Die Staatskanzleien der Bundesländer berieten sich heute in einer Telefonschalte. Über das erste Ergebnis sprechen wir im Podcast. Außerdem: Der größte deutsche Sportverband, der Deutsche Fußball-Bund (DFB) und die Privathäuser einiger Funktionäre wurden am Morgen mit 200 Ermittlern durchsucht. Die Frankfurter Staatsanwaltschaft wirft dem DFB und sechs nicht namentlich genannten früheren oder aktiven Funktionären Steuerhinterziehung in besonders schweren Fällen vor, es geht um fast fünf Millionen Euro. Im Podcast blickt Oliver Fritsch, Sportredakteur, auf die eingeleiteten Ermittlungen. Und Herbert Feuerstein ist gestorben. Das teilte der WDR mit. Ein kurzer Nachruf auf sein Werk. Was noch? Der Lockdownbaum ist weg. Moderation und Produktion: Fabian Scheler Fragen, Kritik, Anregungen? Sie erreichen uns unter wasjetzt@zeit.de Weitere Links zur Sendung: So funktioniert das neue Universalwerkzeug: https://www.zeit.de/video/2016-06/4948764858001/crispr-so-funktioniert-das-universalwerkzeug-der-gentechnik Crispr: "Menschenzüchtung muss tabu bleiben" https://www.zeit.de/wissen/2016-06/crispr-ethikrat-erbgut-zuechtung Crispr: Der letzte Tabubruch der Gentechnik? https://www.zeit.de/wissen/2018-11/crispr-china-geburt-zwillinge-erbanlage-genveraenderung-hiv-resistenz Crispr-Themenseite bei ZEIT ONLINE: https://www.zeit.de/thema/crispr Corona-Regeln: Was man wo in Deutschland darf https://www.zeit.de/gesellschaft/2020-10/corona-regeln-deutschland-maskenpflicht-veranstaltungen-buero-bundeslaender-uebersicht

Non era mai accaduto nella storia dei Nobel. Due donne hanno vinto insieme il Nobel per la chimica: Emmanuelle Charpentier e a Jennifer A. Doudna per aver inventato la tecnica di editing genomico CRISPR-Cas9.

Emmanuelle Charpentier und Jennifer A. Doudna bekommen den Chemie-Nobelpreis für die Erforschung von Methoden zur Erbgut-Veränderung durch die Genschere CRISPR/Cas. Die Französin Charpentier leitet die Max-Planck-Forschungsstelle für die Wissenschaft der Pathogene in Berlin. Martin Gramlich im Gespräch mit dem Wissenschaftsjournalisten Hellmuth Nordwig.

Emmanuelle Charpentier hat zusammen mit ihrer Kollegin Jennifer A. Doudna die Genschere CRISPR/Cas entwickelt und damit die moderne Genetik revolutioniert.

Continuamos en Estocolmo, donde se reveló el nombre de las ganadoras del Premio Nobel de Química: la microbióloga francesa Emmanuelle Charpentier, de la Unidad Max Planck para la ciencia de los patógenos en Berlín; y la bioquímica estadounidense Jennifer A. Doudna, de la Universidad de California en Berkeley.

Muy poco después de su desarrollo, la técnica de edición génica conocida como CRISP-R comenzó a utilizarse en Uruguay. La doctora Martina Crispo, directora de la unidad de animales Transgénicos y de Experimentación del Institut Pasteur de Montevideo, comenzó a trabajar con las "tijeras genéticas" en 2014, generando resultados muy rápidamente. Trabajan con animales y vegetales y su desarrollo ha transformado a esta técnica en un poderoso aliado de la investigación nacional. Las ganadoras del Nobel de Química 2020 son Emmanuelle Charpentier y Jennifer A. Doudna.

A francesa Emmanuele Charpentier e a americana Jennifer A. Doudna foram as cientistas vencedoras do Nobel de Química; 2020 teve o mês de setembro mais quente até hoje, de acordo com serviço europeu Copérnico; líder da oposição em Belarus reúne-se com deputados franceses; candidatos à vice-presidência dos EUA debatem nesta quarta (07); metade da população do enclave de Nagorno Karabakh foge de confrontos armados na região; Uma parceria da Agência Radioweb com a Rádio França Internacional.

Christine Shearer is Senior R&D Engineer at Annie’s Homegrown in Berkeley, CA. We talk about food science, socially responsible practices, and innovation. For more information: Annie’s Homegrown website A Crack in Creation: Gene Editing and the Unthinkable Power to Control Evolution by Jennifer A. Doudna and Samuel H. Sternberg Sporkful podcast BBC’s The Food Chain podcast

Sam Harris speaks with Jennifer Doudna about the gene-editing technology CRISPR/Cas9. They talk about the biology of gene editing, how specific tissues in the body can be targeted, the ethical implications of changing the human genome, the importance of curiosity-driven science, and other topics. Jennifer A. Doudna is a professor in the Chemistry and the Molecular and Cell Biology Departments at the University of California, Berkeley, investigator with the Howard Hughes Medical Institute, and researcher in the Molecular Biophysics and Integrated Bioimaging Division at the Lawrence Berkeley National Laboratory. She is internationally recognized as a leading expert on RNA-protein biochemistry, CRISPR biology, and genome engineering. She is the author (with Samuel Sternberg) of A Crack in Creation: Gene Editing and the Unthinkable Power to Control Evolution.

This week, Amazon primes Whole Foods, Uber has a new head, Samsung loses its head, Half-Life comes to an end(?), Germany solves "the trolley problem", and much more.  What We're Playing With Andy: HBO's Room 104: Ep. 5 “The Internet” Headlines Uber makes CEO pick official, Kalanick makes first comment Uber says it'll stop tracking riders after they're dropped off Samsung Heir Is Found Guilty of Corruption in Blockbuster Trial 'Half Life' writer reveals what could've been Episode 3 Audible Book of the Week A Crack in Creation: Gene Editing and the Unthinkable Power to Control Evolution by Jennifer A. Doudna, Samuel H. Sternberg F.D.A. Approves First Gene-Altering Leukemia Treatment, Costing $475,000 Sign up at AudibleTrial.com/TheDrillDown Music Break: Lost in the Supermarket by The Clash Hot Topic: Amazon + Whole Foods Amazon Cuts Whole Foods Prices as Much as 43% on First Day Amazon's Whole Foods deal will make Alexa a lot smarter Amazon Cortana Music Break: Airbag by Radiohead Final Word: The Trolley Problem Kill animals and destroy property before hurting humans, Germany tells future self-driving cars Cummins beats Tesla to EV semi truck The Drill Down Video of the Week The Trolley Problem: Consequentialism as illustrated by “I, Robot” Subscribe! The Drill Down on iTunes (Subscribe now!) Add us on Stitcher! The Drill Down on Facebook The Drill Down on Twitter Geeks Of Doom's The Drill Down is a roundtable-style audio podcast where we discuss the most important issues of the week, in tech and on the web and how they affect us all. Hosts are Geeks of Doom contributor Andrew Sorcini (Mr. BabyMan), marketing research analyst Dwayne De Freitas, and Box product manager Tosin Onafowokan.