Podcast appearances and mentions of kim eagle

Send us a textThis episode highlights the importance of embracing the journey of self-discovery while navigating societal pressures. Kim Eagle elucidates the distinction between being stuck and being scared, urging listeners to confront their fears and pursue their truths. - Introduction to Kim and her journey into therapy - The significance of being a seeker - Fear versus genuine obstacles in life - The impact of codependency on self-worth - Embracing discomfort as a pathway to growth - Tools for managing feelings of rejection and validation Where to find Kim Eagle: Visit her website at kimeagle.com for resources and to connect on social media. Support the showFollow Playing Injured on Instagram: https://www.instagram.com/playinginjured/

With Dr. Kim Eagle, a cardiologist from the University of Michigan and the Director of the Frankel Cardiovascular Center.   Did you know that October is Sudden Cardiac Arrest Awareness Month? What is a sudden cardiac arrest and how does it differ from a heart attack? Although the two are thought to be similar, they are actually quite different. A heart attack occurs when there is an insufficient flow of blood to the heart. This is typically caused by a circulatory problem such as a blockage or an Aneurysm. But a sudden cardiac arrest results from “an electrical failure” where the heart malfunctions due to an irregular rhythm and suddenly stops beating. While a heart attack may be preceded by a history of warning symptoms, such as fatigue or shortness of breath, a sudden cardiac arrest or SCA usually occurs without warning, and in 95% of the cases, it will be fatal. Although an unexpected blow to the chest, such as the one suffered by the Buffalo Bills' Damar Hamlin, could disrupt the heart's electrical rhythm, an acute onset of emotional distress or anxiety could also trigger life-threatening arrhythmias. The signs of sudden cardiac arrest are a sudden collapse and the loss of consciousness. If a person has stopped breathing after collapsing, it is likely they're experiencing an SCA. It is critical to act immediately by calling 911 and promptly administering CPR. The likelihood of survival may increase if you have access to a portable defibrillator, more commonly known as an AED. These devices are frequently found in public places such as sports stadiums and come equipped with voice-guided instructions for use by untrained individuals. Prior to her death in October of 2023, Florine recorded an interview with Dr. Kim Eagle, a renowned cardiologist from the University of Michigan and the Director of the Frankel Cardiovascular Center. If you want to learn more about the signs and symptoms of heart disease and the simple lifestyle changes that could lessen your risk of a heart attack, please listen to Florine's interview with Dr. Eagle.   Please note: This episode was previously recorded prior to Florine's death in October of 2023.   What You'll Hear in This Episode: How does heart disease impact other health conditions such as diabetes, high blood pressure, and obesity? What type of screening occurs for cardiac health? The importance of getting an annual physical. How does the lack of resources affect those who get treated for cardiovascular disease? What are four simple things we can do to improve our heart health today? What foods should we avoid for heart disease, and which should we try to eat more of? What about coffee or alcohol? How regular exercise helps to extend our life span. How Dr. Kim gets in his 10,000+ steps a day.   Today's Takeaway: I want to thank Dr. Kim Eagle for being my guest today. Heart disease is the leading cause of death for men and women in the United States. Every 36 seconds, someone in the U.S. dies from cardiovascular disease. On an annual basis, every one in four deaths in the U.S. are caused by heart disease. Since 2014, the financial toll in the U.S. from heart-related deaths including medical services, prescription drugs, and loss of productivity due to death exceeds $219 billion per year. That's $219 billion and this year's numbers might well exceed that figure due to the complications of COVID-19! Something's got to change. If you want to ensure that you and your loved ones don't become part of these statistics, Dr. Eagle has given us four simple changes that you can implement today. If you just follow his suggestions, you can lessen your risk of developing heart disease. I'm Florine Mark, and that's “Today's Takeaway.”   Quotes: When we talk to patients about trying to understand their risk and prevent future events, the first thing is to start with understanding their numbers, and that requires them to work with a doctor.” — Dr. Eagle [4:52] “It's very important to have an annual physical.” — Dr. Eagle [6:05] “Cardiovascular disease and resources matter.” — Dr. Eagle [6:35] “When there is a disparity of socio-economic status, this can then lead to a lack of access to medical care, preventive therapies, and so forth.” — Dr. Eagle [7:51] “If you look at your plate, you want your plate to be rich in color, full of fruits and fresh vegetables.” — Dr. Eagle [12:07] “A Mediterranean diet is rich in fruits and vegetables, where the protein is a healthy protein.” — Dr. Eagle [13:11] “Any movement at all is incredibly healthy for cardiovascular health, and also mental health.” — Dr. Eagle [16:37]   Brought to You By: Gardner White Furniture   Mentioned in This Episode: Dr. Kim Eagle Frankel Cardiovascular Center, University of Michigan Health  

The Beat with Joel Dunning Ep. 8 In this episode, Joel addresses a machine learning model improving mortality risk prediction for cardiac surgery patients, the efficacy of thoracoscopic surgery for descending necrotizing mediastinitis, and a study examining diversity and compensation among cardiothoracic surgeons. He also talks about a minimally invasive mitral valve repair, repair by translocation of anomalous origin of the left coronary artery, and a global surgeon spotlight. After discussing upcoming events in the CT surgery world, Joel closes with a shoutout to Kim Eagle and Thomas Crawford for their work with My Heart Your Heart.   JANS Items Mentioned Researchers Show That a Machine Learning Model Can Improve Mortality Risk Prediction for Cardiac Surgery Patients Efficacy of Thoracoscopic Surgery for Descending Necrotizing Mediastinitis Exploring Diversity, Compensation Among Academic Cardiothoracic Surgeons   CTSNet Content Mentioned Minimally Invasive Off-Pump Mitral Valve Repair with the NeoChord DS1000 System Anomalous Origin of the Left Coronary Artery from the Pulmonary Artery (ALCAPA): Repair by Translocation   Global Surgeon Spotlight: An Interview with Professor Barasa Otsyula   Other Items Mentioned CTSNet Events Calendar My Heart Your Heart  

Drs. Deepak Bhatt, Kim Eagle and Payal Kohli review Day 2 late-breaking science from AHA 2022, including ECMO-CS (0:42), RESPECT-EPA (2:22), ISCHEMIA-EXTENDed (5:45) and EMPA-KIDNEY (7:39). The ACC is providing coverage of the hottest AHA 2022 science. For trial summaries, news coverage, daily video wrap-ups and more, visit ACC's Meeting Coverage page and follow the ACC on social media using the hashtag #AHA22 to join the conversation.

Drs. Deepak Bhatt, Kim Eagle and Payal Kohli review Day 3 late-breaking science from AHA 2022, including ENHANCE-AF (0:32), PRECSION (2:40), BrightHTN (4:08), and SPYRAL HTN-ON (6:41). The ACC is providing coverage of the hottest AHA 2022 science. For trial summaries, news coverage, daily video wrap-ups and more, visit ACC's Meeting Coverage page and follow the ACC on social media using the hashtag #AHA22 to join the conversation.

In this special AHA episode of Eagle's Eye View, Drs. Deepak Bhatt, Kim Eagle and Payal Kohli discuss highlights from Day 1 of the AHA 2022 late-breaking science, including TRANSFORM-HF, DCP, PROMINENT, and IRONMAN. The ACC is providing coverage of the hottest AHA 2022 science. For trial summaries, news coverage, daily video wrap-ups and more, visit ACC's Meeting Coverage page and follow the ACC on social media using the hashtag #AHA22 to join the conversation.

The Federal Reserve on Wednesday intensified its drive to tame high inflation by raising its key interest rate by three-quarters of a point — its largest hike in nearly three decades — and signaling more large rate increases to come that would raise the risk of another recession.The move the Fed announced after its latest policy meeting will increase its benchmark short-term rate, which affects many consumer and business loans, to a range of 1.5% to 1.75%.The central bank is ramping up its drive to tighten credit and slow growth with inflation having reached a four-decade high of 8.6%, spreading to more areas of the economy and showing no sign of slowing. Americans are also starting to expect high inflation to last longer than they had before. This sentiment could embed an inflationary psychology in the economy that would make it harder to bring inflation back to the Fed's 2% target.The Fed's three-quarter-point rate increase exceeds the half-point hike that Chair Jerome Powell had previously suggested was likely to be announced this week. The Fed's decision to impose a rate hike as large as it did Wednesday was an acknowledgment that it's struggling to curb the pace and persistence of inflation, which has been worsened by Russia's war against Ukraine and its effects on energy prices.Borrowing costs have already risen sharply across much of the U.S. economy in response to the Fed's moves, with the average 30-year fixed mortgage rate topping 6%, its highest level since before the 2008 financial crisis, up from just 3% at the start of the year. The yield on the 2-year Treasury note, a benchmark for corporate borrowing, has jumped to 3.3%, its highest level since 2007.READ MORE: https://www.wcnc.com/article/news/nation-world/fed-rate-hike/507-712efdf8-4e15-42f6-a21e-9c5b33328ca7'An exhibit highlighting photography will be without a photo taken during a Charlotte Pride event after a decision from the Gaston County manager.The Gaston County Museum of Art and History is currently displaying Into the Darkroom, a photography exhibit aimed at showing photography's use as an art form and its place in history.The exhibit uses photos from the 20th century, showcases vintage cameras, and features work from four modern photographers in Gaston County. One of these photographers, Grant Baldwin, used a photo he took at the 2019 Charlotte Pride Parade of two men kissing. Baldwin says the photo was taken during a marriage proposal.However, shortly after opening the exhibit, this photo was removed.Gaston County officials state this decision was made after Kim Eagle, the county manager, instructed museum staff to work with Baldwin to select another photograph to highlight."The idea behind the exhibit is to document a historical event, and there are other options from the photographer's work that more fully capture the context of the parade that was documented," the county said in a statement.The decision did not involve the museum's board of commissioners.READ MORE: https://www.wcnc.com/article/news/local/lgbtq-photo-removed-from-gaton-county-museum-photographer-speaks-out-pride-men-kissing/275-f25200f5-8b5f-45a5-88ca-9da4edaf3f83Watch Wake Up Charlotte each weekday morning from 4:30 to 7 a.m. on WCNC Charlotte, and as always, join the conversation on social media using #WakeUpCLT! 

The Federal Reserve on Wednesday intensified its drive to tame high inflation by raising its key interest rate by three-quarters of a point — its largest hike in nearly three decades — and signaling more large rate increases to come that would raise the risk of another recession. The move the Fed announced after its latest policy meeting will increase its benchmark short-term rate, which affects many consumer and business loans, to a range of 1.5% to 1.75%. The central bank is ramping up its drive to tighten credit and slow growth with inflation having reached a four-decade high of 8.6%, spreading to more areas of the economy and showing no sign of slowing. Americans are also starting to expect high inflation to last longer than they had before. This sentiment could embed an inflationary psychology in the economy that would make it harder to bring inflation back to the Fed's 2% target. The Fed's three-quarter-point rate increase exceeds the half-point hike that Chair Jerome Powell had previously suggested was likely to be announced this week. The Fed's decision to impose a rate hike as large as it did Wednesday was an acknowledgment that it's struggling to curb the pace and persistence of inflation, which has been worsened by Russia's war against Ukraine and its effects on energy prices. Borrowing costs have already risen sharply across much of the U.S. economy in response to the Fed's moves, with the average 30-year fixed mortgage rate topping 6%, its highest level since before the 2008 financial crisis, up from just 3% at the start of the year. The yield on the 2-year Treasury note, a benchmark for corporate borrowing, has jumped to 3.3%, its highest level since 2007. READ MORE: https://www.wcnc.com/article/news/nation-world/fed-rate-hike/507-712efdf8-4e15-42f6-a21e-9c5b33328ca7' An exhibit highlighting photography will be without a photo taken during a Charlotte Pride event after a decision from the Gaston County manager. The Gaston County Museum of Art and History is currently displaying Into the Darkroom, a photography exhibit aimed at showing photography's use as an art form and its place in history. The exhibit uses photos from the 20th century, showcases vintage cameras, and features work from four modern photographers in Gaston County. One of these photographers, Grant Baldwin, used a photo he took at the 2019 Charlotte Pride Parade of two men kissing. Baldwin says the photo was taken during a marriage proposal. However, shortly after opening the exhibit, this photo was removed. Gaston County officials state this decision was made after Kim Eagle, the county manager, instructed museum staff to work with Baldwin to select another photograph to highlight. "The idea behind the exhibit is to document a historical event, and there are other options from the photographer's work that more fully capture the context of the parade that was documented," the county said in a statement. The decision did not involve the museum's board of commissioners. READ MORE: https://www.wcnc.com/article/news/local/lgbtq-photo-removed-from-gaton-county-museum-photographer-speaks-out-pride-men-kissing/275-f25200f5-8b5f-45a5-88ca-9da4edaf3f83 Watch Wake Up Charlotte each weekday morning from 4:30 to 7 a.m. on WCNC Charlotte, and as always, join the conversation on social media using #WakeUpCLT! 

: In this special ACC.22 episode of Eagle's Eye View, Drs. Kim Eagle, Payal Kohli and Deepak Bhatt discuss highlights from Day 3 of the ACC.22 late-breaking science and featured clinical research, including POISE-3, SPYRAL HTN-ON MED, EMPULSE, and FIDELITY.

In this special ACC.22 episode of Eagle's Eye View, Drs. Kim Eagle, Payal Kohli and Deepak Bhatt discuss highlights from Day 2 of the ACC.22 late-breaking science and featured clinical research, including PACMAN AMI, SuperWIN, DIAMOND, and IVVE.

In this special ACC.22 episode of Eagle's Eye View, Drs. Kim Eagle, Payal Kohli and Deepak Bhatt discuss highlights from Day 1 of the ACC.22 late-breaking science and featured clinical research, including CHAP, SCORED, COMPLETE, and Bentracimab.

Drs. Deepak Bhatt, Payal Kohli, and Kim Eagle discuss highlights from the hottest clinical trials presented during Day 3 of the 2021 AHA Annual Scientific Session, including the PREPARE-IT 2 (0:32), AXIOMATIC-TKR (3:49), ASCEND (6:34), and REVERSE-IT (9:46) trials.   Subscribe to Eagle's Eye View

Drs. Deepak Bhatt, Payal Kohli, and Kim Eagle discuss highlights from the hottest clinical trials presented during Day 2 of the 2021 AHA Annual Scientific Session, including trials EMPULSE (0:28), EMPEROR-Preserved (2:21), CHIEF-HF (4:05), and PALACS (7:43).     Subscribe to Eagle's Eye View

Drs. Deepak Bhatt, Payal Kohli, and Kim Eagle discuss highlights from the hottest clinical trials presented during Day 1 of the 2021 AHA Annual Scientific Session, including trials on aortic valve replacement vs. watchful waiting in severe AS (AVATAR), and evaluating the benefit of concomitant tricuspid repair during mitral valve surgery (CTCR-MVS).     Subscribe to Eagle's Eye View

In this special episode of Eagle’s Eye View, Dr. Kim Eagle, Dr. Deepak Bhatt, and Dr. Payal Kohli discuss highlights from Day 3 of ACC.21, including SOLOIST and SCORED, LIFE, GALACTIC-HF, FIDELIO-DKD, and RESCUE.

In this special episode of Eagle’s Eye View, Dr. Kim Eagle, Dr. Deepak Bhatt, and Dr. Payal Kohli discuss highlights from Day 2 of ACC.21, including FLOWER-MI, DARE-19, COALITION ACTION, REHAB-HF, HOST-EXAM, and RADIANCE-HTN TRIO.

In this special episode of Eagle’s Eye View, Dr. Kim Eagle, Dr. Deepak Bhatt, and Dr. Payal Kohli discuss highlights from Day 1 of ACC.21, including LAAOS III, ATLANTIS, ADAPTABLE, EXPLORER-HCM, and PARADISE-MI.

In this episode, Kim Eagle, MD, MACC, asks Matthew Martinez, MD, FACC, and Steve Ommen, MD, FACC, all of the questions you wish you could ask about hypertrophic cardiomyopathy and the new ACC guidelines. 

In this episode, Kim Eagle, MD, MACC, asks Matthew Martinez, MD, FACC, and Steve Ommen, MD, FACC, all of the questions you wish you could ask about hypertrophic cardiomyopathy and the new ACC guidelines. 

In this special episode of the View, Deepak Bhatt, MD, MPH, FACC, joins Kim Eagle, MD, MACC, to discuss the top journal scans and clinical trials from 2020.

In this episode, Michael Mack, MD, MACC, Kim Eagle, MD, MACC, and Rebecca Hahn, MD, FACC, discuss important changes in the 2020 valvular guideline update.

In this special episode of Eagle’s Eye View, Dr. Kim Eagle, Dr. Peter Block, and Dr. Deepak Bhatt discuss highlights from Day 4 of AHA 2020, including SEARCH-AF, FIDELIO, THALES, RHAPSODY, SOLOIST-WHF, and SCORED.

In this special episode of Eagle’s Eye View, Dr. Kim Eagle, Dr. Peter Block, and Dr. Deepak Bhatt discuss highlights from Day 5 of AHA 2020, including results from the INVESTED trial.

In this special episode of Eagle’s Eye View, Dr. Kim Eagle and Dr. Deepak Bhatt discuss highlights from Day 3 of AHA 2020, including STRENGTH, OMEMI, EXPLORER-HCM, One-Month DAPT, and COLCOT Diabetes.

In this special episode of Eagle’s Eye View, Dr. Kim Eagle and Dr. Deepak Bhatt discuss highlights from Day 1 of AHA 2020, including GALACTIC-HF, AFFIRM-AHF, VITAL-Rhythm, ARREST, TIPS-3, DAPA-CKD, and EMPEROR-Reduced.

In this special episode of Eagle’s Eye View, Dr. Kim Eagle and Dr. Deepak Bhatt discuss highlights from Day 2 of AHA 2020, including ALPHEUS and RIVER.

In this special episode of Eagle’s Eye View, Dr. Kim Eagle, Dr. Peter Block, and Dr. Deepak Bhatt discuss highlights from Day 4 and Day 5 of TCT 2020, including Anatomy of Human Accessory Renal Artery Peri-Arterial Renal Sympathetic Nerve for Renal Denervation and IREMMI.

In this special episode of Eagle’s Eye View, Dr. Kim Eagle, Dr. Peter Block, and Dr. Deepak Bhatt discuss highlights from Day 3 of TCT 2020, including DEFINE-FLOW, REFLECT II, and STS/ACC TVT Registry.

In this special episode of Eagle’s Eye View, Dr. Kim Eagle, Dr. Peter Block, and Dr. Deepak Bhatt discuss highlights from Day 2 of TCT 2020, including Disrupt CAD III, SCOPE II, and ULTIMATE.

In this special episode of Eagle’s Eye View, Dr. Kim Eagle, Dr. Peter Block, and Dr. Deepak Bhatt discuss highlights from Day 1 of TCT 2020, including PROSPECT ABSORB and TICO-STEMI.

CardioNerds (Amit Goyal & Daniel Ambinder) join University of Michigan cardiology fellows (Apu Chakrabarti, Jessica Guidi, and Amrish Deshmukh) for some craft brews in Ann Arbor! They discuss a challenging case of Ventricular Septal Rupture after acute MI. Dr. Kim Eagle, editor of ACC.org & host of Eagle's Eye View Podcast, and Dr. Devraj Sukul provide the E-CPR and message for applicants. Episode notes were developed by Johns Hopkins internal medicine resident, Eunice Dugan, with mentorship from University of Maryland cardiology fellow Karan Desai.   Jump to: Patient summary - Case media - Case teaching - References D The CardioNerds Cardiology Case Reports series shines light on the hidden curriculum of medical storytelling. We learn together while discussing fascinating cases in this fun, engaging, and educational format. Each episode ends with an “Expert CardioNerd Perspectives & Review” (E-CPR) for a nuanced teaching from a content expert. We truly believe that hearing about a patient is the singular theme that unifies everyone at every level, from the student to the professor emeritus. We are teaming up with the ACC FIT Section to use the #CNCR episodes to showcase CV education across the country in the era of virtual recruitment. As part of the recruitment series, each episode features fellows from a given program discussing and teaching about an interesting case as well as sharing what makes their hearts flutter about their fellowship training. The case discussion is followed by both an E-CPR segment and a message from the program director. CardioNerds Case Reports PageCardioNerds Episode PageCardioNerds AcademySubscribe to our newsletter- The HeartbeatSupport our educational mission by becoming a Patron!Cardiology Programs Twitter Group created by Dr. Nosheen Reza Patient Summary A male in his 60s with medical history of obesity and GERD presents with five days of progressive chest pressure radiating to bilateral arms and associated with dyspnea on exertion. Due to worsening chest pain with new lightheadedness, he decided to come to the ED. His presentation to the hospital was delayed due to fear of contracting COVID-19. In the ED, patient was afebrile, blood pressure 96/56, HR 137, RR 22, and oxygen saturation 94% on room air. On exam, he was ill appearing, acutely distressed, and altered. He had a 3/6 mid systolic murmur loudest at L sternal border, JVP to 10 cm H2O and had crackles up to mid-lung fields. His extremities were cool to touch. Labs notable for Cr 1.5, High-Sensitivity Troponin-T up to 5756, and lactate 3.9. EKG showed incomplete RBBB, PVCs, and ST elevations in the inferior leads with depressions in lateral and precordial leads. Coronary Angiography showed mid-RCA occlusion with faint L to right collaterals. He underwent PCI with restoration of TIMI 3 flow. After PCI, he continued to be hypotensive requiring IABP and norepinephrine. PA catheter demonstrated (in mmHg): RA 26, RV 63/29 (31), 55/36 (44), PCWP 29, and CO 5 L/min, CI 2.2, and SVR 467. Shunt run of mixed venous O2 saturation showed: SVC 71%, RA 72%, RV 62%, PA 85% with oxygen step up in the R-sided circuit. Left ventriculogram then confirmed septal rupture with contrast extravasation from LV into RV. Due to worsening shock, he was stabilized on VA ECMO which was complicated by hemolysis and acute renal failure requiring CVVHD. On day 7 after presentation, he underwent surgery which revealed a large 6x6 cm ventricular septal defect on the posterior aspect of the septum and repaired with a large bovine pericardial path. He was eventually discharged after a prolonged stay and repeat TTE on follow up showed biventricular dysfunction and residual 1cm VSD.   Case Media ABCDClick to Enlarge A. ECG: Incomplete RBBB, PVCs, and ST elevations in the inferior leads with depressions in lateral and precordial leads. B. Coronary angiography: mid-RCA occlusion with faint L to right collaterals.C-D.

In this special episode of Eagle's Eye View, Dr. Deepak Bhatt, Dr. Kim Eagle, and Dr. Gabriel Steg discuss highlights from Day 4 of ESC Congress 2020, including THEMIS-PAD, BRACE CORONA, and REALITY.

In this special episode of Eagle's Eye View, Dr. Deepak Bhatt, Dr. Kim Eagle, and Dr. Gabriel Steg discuss highlights from Day 3 of ESC Congress 2020, including HOME-PE and LoDoCo2.

In this special episode of Eagle's Eye View, Dr. Deepak Bhatt, Dr. Kim Eagle, and Dr. Gabriel Steg discuss highlights from Day 2 of ESC Congress 2020, including VOYAGER PAD, BAMI, ATPCI, POPULAR TAVI, PARALLAX, and DAPA-CKD.

In this special episode of Eagle's Eye View, Dr. Deepak Bhatt, Dr. Kim Eagle, and Dr. Gabriel Steg discuss highlights from Day 1 of ESC Congress 2020, including COLCOT, COPS, EVAPORATE, EMPEROR-Reduced, EAST – AFNET 4, and EXPLORER-HCM.

Kim Eagle is the founder of Earn that Body, an online nutrition and fitness training company. This conversation isn't your typical, "How to Avoid Gaining 10 Pounds During the Holidays" or "How to Get Your Six Pack." This episode explores Kim, the entrepreneur, on the origins of her online coaching business and how she balances virtually every aspect of the business. Yes, she is the face of 'Earn that Body,' but she's also the Marketing Director, the Head Coach, the Social Media Director, the Accountant, the Business Manager, the Podcaster, the Curriculum Creator, and more.  It's an honest look at the intensive work that goes into every facet of this business. Enjoy this glimpse behind the glamour.  To learn more about Kim and her programs: https://www.earnthatbody.com/  

In this special episode of the View, Dr. Peter Block, Dr. Kim Eagle, and Dr. Deepak Bhatt discuss highlights from Day 2 of AHA.19, including the effect of treatment according to age in the DAPA-HF trial, early surgery versus conventional management for asymptomatic severe aortic stenosis in the RECOVERY trial, and results from the 3,146 patients randomized in the United States in the REDUCE-IT USA trial.

In this special episode of the View, Dr. Peter Block, Dr. Kim Eagle, and Dr. Deepak Bhatt discuss highlights from Day 3 of AHA.19, including Evaporate: Icosapent Ethyl on Progression of Coronary Atherosclerosis in Patients With Elevated Triglycerides on Statin, the Treat Stroke To Target trial results, and Impella versus intra-aortic balloon pump in the United States.

Hosted by: Dr. Danielle Belardo Instagram: @theveggiemd Twitter: @theveggiemd Facebook: The Veggie MD Produced by: Dr. Kasey Johnson Instagram: @drkaseyjohnson   This weeks episode, is ALL about Cardiology (and plant based nutrition of course)!  Research, research, research! Last weekend was the Annual American College of Cardiology National Meeting, where cardiologists from around the world present new research, guidelines, data and evidence in all areas of cardiovascular disease.  I interviewed two esteemed cardiologists during and after ACC 2019.    If you didn't get to attend ACC this year, get ready for your front row seat in this episode! Dr. Robert Ostfeld will take you through his ACC 2019 nutrition presentation, where he will take us through the evidence, research studies, and peer reviewed literature which support a whole food plant based diet as being the most healthful for cardiovascular disease prevention.  Additionally, he tackles the Mediterranean diet AND keto diet, and explains just why plant based diet takes first place.    The second half of the episode, I had the honor to interview Dr. Kim Eagle, who is the editor of the ACC’s website, ACC.org, and the creator of my favorite cardiology podcast, ACC's Eagles Eye View.  We discuss the exciting trials being released at ACC 2019, how to adequately evaluate research studies, and more.     About Kim Eagle MD:  Dr. Kim Eagle is the Albion Walter Hewlett Professor of Internal Medicine, Professor of Health Management and Policy at the University of Michigan School of Public Health, and Director of the Frankel Cardiovascular Center at the University of Michigan. He attended Oregon State University, graduating in 1976 followed by Tufts University Medical School, graduating in 1979. He completed a residency and chief residency in Internal Medicine at Yale-New Haven Hospital from 1979 to 1983 followed by research and clinical fellowships in cardiology and health services research at Harvard Medical School and The Massachusetts General Hospital (MGH) from 1983 through 1986. From 1986 to 1994, Dr. Eagle served MGH where he was promoted to Associate Director of Clinical Cardiology and Associate Professor of Medicine at Harvard before moving to the University of Michigan.  At the University of Michigan, beginning in 1994, Dr. Eagle developed an outcomes research program focusing on quality, cost-effectiveness, practice guidelines, acute coronary syndromes, treatment of aortic diseases, the fight against childhood obesity (Founder -“Project Healthy Schools”), heart disease in special populations and reuse of pacemakers in third world nations (Founder – “Project My Heart Your Heart”). His outcomes research team has led quality improvement initiatives across the state of Michigan in acute MI, heart failure, and coronary intervention. Dr. Eagle has contributed extramural presentations to more than 110,000 learners in 33 U.S. states and 11 countries. He has published 591 peer-reviewed articles, 69 chapters, and edited 8 books including his latest, The Heart of a Champion, co-written with legendary Michigan football coach, Bo Schembechler.  Dr. Eagle has served the American College of Cardiology on numerous committees and task forces. He is the editor of the ACC’s website, ACC.org. He served its Board of Trustees from 2001-2005. He received ACC’s “Master” designation in 2009, and its national Distinguished Teacher Award in 2012.  He served on the National Heart, Lung and Blood Institute’s External Advisory Committee from 2002-2006, and has been Study Chair of its Genetic Causes of Thoracic Aortic Conditions (GenTAC) since 2006. He has served the local and national American Heart Association and he received the national AHA’s Laennec Society’s Clinician Educator Award in 2013. He is past President of the Association of University Cardiologists and a Board Member of the World Medical Relief. In 2014, the University of Michigan and many of Dr. Eagle’s grateful patients created the Kim A. Eagle Professorship in Cardiovascular Medicine and an endowed research fund bearing his name. About Rob Ostfeld MD Robert Ostfeld, MD, MSc, FACC, a cardiologist, is the Director of Preventive Cardiology, the founder and director of the Cardiac Wellness Program at Montefiore Health System, and an Associate Professor of Medicine at the Albert Einstein College of Medicine. Dr. Ostfeld earned his BA from the University of Pennsylvania, graduating Summa Cum Laude and Phi Beta Kappa; his MD from Yale University School of Medicine; and his Masters of Science in Epidemiology from the Harvard School of Public Health. Dr. Ostfeld completed his medical internship and residency at the Massachusetts General Hospital and his cardiology fellowship and research fellowship in Preventive Medicine at Brigham and Women's Hospital - both teaching hospitals of Harvard Medical School.   His professional interests include cardiovascular disease prevention, medical education and clinical research. He speaks widely regarding nutrition and prevention. He earned the Outstanding Full Time Attending of the Year award at Montefiore for excellence in teaching medical residents; the Program Directors Award for dedicated service on behalf of the Montefiore-Einstein Cardiology Fellowship; and was elected to the Leo M. Davidoff Society at Einstein for outstanding achievement in the teaching of medical students.

In this special episode of Eagle’s Eye View, Dr. Peter Block, Dr. Kim Eagle, and Dr. Deepak Bhatt discuss highlights from Day 3 of ACC.19, including IRAD: Acute Aortic Dissection: Lessons Learned From 9000 Patients, REDUCE-IT: Reduction in Total Ischemic Events With Icosapent Ethyl, DECLARE-TIMI 58 HFrEF: Dapagliflozin on HF and Mortality in T2D Based on EF, and SAFARI-STEMI: Femoral Access vs. Radial Access For Primary PCI in STEMI.

In this special episode of Eagle’s Eye View, Dr. Peter Block, Dr. Kim Eagle, and Dr. Deepak Bhatt discuss highlights from Day 2 of ACC.19, including PARTNER 3: TAVR or SAVR in Low-Risk Patients, AUGUSTUS: Apixaban vs. Vitamin K Antagonist and Aspirin vs. Placebo in AFib and ACS, PCI, POET: Partial Oral Treatment of Left-Sided Infectious Endocarditis, and MOMENTUM 3: MagLev Technology in Mechanical Circulatory Support Therapy With HeartMate 3.

Kim Eagle shares how her business Earn that Body got started and how it is impacting the lives of people all over the country. Kim journeys with customers holding them accountable with exercise and food programs and the results are undeniable.

  She's been voted Austin's Best Personal Trainer for multiple years, but this Top Nutrition Trainer has clients around the globe! In this talk recorded live at Bicycle World in Austin, Founder and CEO of Earn that Body, Kim Eagle, dispenses her Top 10 Tips for Healthy Weight Loss.   Bad news for you folks expecting a quick fix or some magic solution - it doesn't exist. But, by implementing some common sense changes into your daily routine, you can lose unwanted pounds and start chasing peak performance!  To receive a copy of Kim's notes and recipes from this talk, go to  shockthatbody.com/bicycleworld   Copyright 2019 All Rights Reserved

In this special episode of the View, Kim Eagle and Salim Virani discuss the 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol.

In this special episode of the View, Kim Eagle, Peter Block, and Deepak Bhatt discuss the highlights from Day 2 of the 2018 American Heart Association Scientific Sessions, including the Cardiac Remodeling Following Ligation of Arteriovenous Fistula in Stable Renal Transplant Recipients, DTU, ODYSSEY OUTCOMES, and ODYSSEY OUTCOMES Economics trials.

In this special episode of the View, Kim Eagle and Peter Block discuss the highlights from Day 1 of the 2018 American Heart Association Scientific Sessions, including the VITAL, CIRT, and REDUCE-IT trials.

Dr. Carolyn Lam:               Welcome to Circulation on the Run, your weekly podcast summary and backstage pass to the journal and its editors. I'm Dr. Carolyn Lam, Associate Editor from the National Heart Center and Duke National University of Singapore. This week's feature paper takes a deep dive into nitric oxide signaling, that extremely important pathway in cardiovascular health and disease. This time, taking a novel look at genetic predisposition, phenotypic consequences, and therapeutic implications. All that coming right up after these summaries.                                                 The first original paper describes the derivation and validation of a novel model to stratify the risk of death due to circulatory etiology in patients resuscitated from cardiac arrest without an ST elevation MI.                                                 First author, Dr. Bascom, corresponding author Dr. Setter from Maine Medical Center in Portland and their colleagues use the International Cardiac Arrest Registry to derive a novel model termed the CREST Model, which describes an incrementally high risk of circulatory etiology death with an increasing score.                                                 Now, CREST is a simple score with components of C for prior coronary artery disease. R for non-shockable rhythm. E for ejection fraction less than 30% on admission. S for shock at the time of admission. T for ischemic time more than 25 minutes. The authors showed that this CREST tool may allow for estimation of circulatory risk and improve triage of cardiac arrest survivors without STEMI at the point of care.                                                 The next study reports associations between usual sodium, potassium and blood pressure using gold standard 24-hour urinary data collected for the first time among a nationally representative sample of adults in the United States.                                                 First and corresponding author Dr. Jackson from Centers for Disease Control and Prevention used cross-sectional data from 766 participants aged 20 to 69 years with complete blood pressure and 24-hour urine collections in the 2014 national health and nutrition examination survey.                                                 They found that there was a strong direct relationship between higher sodium excretion and higher blood pressure and hypertension. In addition, there was an inverse relationship between potassium excretion and blood pressure and hypertension. When added to the evidence based from longitudinal and interventional studies, these results support clinicians dietary advise to lower sodium intake and increase consumption of potassium containing foods.                                                 The next two studies in this week's journal examine the utility of circulating biomarkers to aid in the diagnosis of acute aortic dissection. As a reminder, the AHA/ACC guidelines published in 2010, proposed using the aortic dissection detection risk score or ADD risk score as a primary screening tool based on scoring the presence of three categorical risks.                                                 Number one, high risk conditions such as Marfan Syndrome, a family history of aortic disease, known aortic valve disease, known thoracic aortic aneurysm or previous aortic manipulation. Number two, The pain features such as chest, back or abdominal pain described as being of abrupt onset severe intensity or ripping, tearing. Number three, the examination features such as evidence of profusion deficit, systolic blood pressure difference, spoken neurological deficit or aortic diastolic murmur and hypertension or shock.                                                 The presence of one or more markers within each of these categorical features is given an ADD score of one with a maximum cumulative score of three if all three categorical features are present. In the first of these two papers in this week's journal, first author Dr. Nazareen, corresponding author Dr. Morello and colleagues from Molinette Hospital in Italy performed the advised International Multi Centers Study, which prospectively assessed the diagnostic performance of standardized strategies integrating pre-test probability assessment and D-dimer in 1,850 patients from the emergency department.                                                 They found that in patients with an ADD risk score above one and D-dimer less than 500 nanograms per milliliter, the rate of acute aortic syndromes was significant at one in 22 cases. Rule out strategies for acute aortic syndromes integrating an ADD risk score of zero or one with D-dimer less than 500 were found to miss only around 1 in 300 cases of acute aortic syndrome.                                                 Integrating the ADD risk score with D-dimer could help to standardize diagnostic decisions on advanced imaging for suspected acute aortic syndrome balancing the risks of misdiagnosis and over testing. The authors concluded that patients at high probability of acute aortic syndrome such as with an ADD risk score above one should proceed to computer tomography and geography or other conclusive imaging irrespective of D-dimer levels.  However, in those with an ADD risk score of zero or one, with a D-dimer of less than 500 were possible rule out diagnostic strategies for acute aortic syndrome.                                                 The second manuscript in the present issue suggests that soluble ST2 might be an even better biomarker than D-dimer to rule out aortic dissection. In this paper by first author, Dr. Wang, co-corresponding authors, Dr. Du and Guo from Beijing Anzhen Hospital and Peking University respectively, the authors measured plasma concentrations of soluble ST2 using the R&D Systems assay in 1,360 patients including 1,027 participants in the retrospective discovery set and 330 patients with an initial suspicion of acute aortic dissection and ruled in a prospective validation cohort.                                                 The proportion of acute aortic dissection, this acute chest pain cohort was high at more than 40%. The authors found that soluble ST2 measured using this research grade assay showed higher levels in acute aortic dissection than in acute myocardial infarction or in acute pulmonary embolism. The result suggested that soluble ST2 levels could be useful as a rule out marker possibly even to an extent moderately superior to D-dimer.                                                 A cut-off level of around 35 nanograms per milliliters using the research grade soluble ST2 assay appeared to reliably rule out acute aortic dissection if used within 24 hours after symptom onset with a negative likelihood ratio of 0.01 and a negative predictive value of more than 99%. These intriguing findings are discussed in an accompanying editorial by Dr. Toru Suzuki from University of Leicester and Dr. Kim Eagle from University of Michigan. Well, that wraps it up for our summaries. Now, for our future discussion.                                                 Nitric oxide signaling plays a key role in the regulation of vascular tone and platelet activation. In fact, the pharmacologic stimulation of nitric oxide pathway is emerging as a therapeutic strategy in cardiovascular medicine in many areas including in heart failure preserved dejection fraction.                                                 Today's paper is therefore all the more intriguing because it seeks to understand the impact of a genetic predisposition to enhanced nitric oxide signaling on the risk for cardiovascular disease as a way of informing of the potential utility of pharmacologic stimulation of the nitric oxide pathway.                                                 Intrigued? Well, I certainly and I'm so glad to have with us the corresponding author, Dr. Sekar Kathiresan from Massachusetts General Hospital as well as a familiar voice, Dr. Peipei Ping, associate editor from UCLA here to discuss this paper.                                                 Sekar, could I ask you as an introduction to tell us a little bit more of the general approach of looking at genetic predisposition as a way of perhaps forecasting potential utility of pharmacologic stimulation? Could you tell us a little bit more about that? Dr. Sekar Kathiresan:      Yes. I'm delighted to speak a little bit more about this idea of using naturally occurring genetic variation to understand if a medicine developed against a target is going to work in terms of efficacy and also potentially lead to on target side effect.                                                 As you know, there are lots of variants for mutations in genes that eventually become targets for medicines. Over the last 10, 15 years, there's been an explosion in our understanding of human genetic variation, specifically in genes targeted by medicines.                                                 The idea here is that if there's a naturally occurring mutation in that target gene, you can simply ask what are the phenotypic consequences of carrying that mutation. Also use that information to predict, as I said, the efficacy of pharmacologic manipulation and potentially on-target side effects. This approach has become a very powerful approach.                                                 A famous recent example of gene, PCSK9, where mutation in this gene occur naturally. A lower function of PCSK9 and individuals who carry this mutations have lower LDL levels and lower risk of heart attack. This information has led to the development of medicine that mimic those mutations and those medicines have been proven now to lower LDL as well as lower risk of heart attack, a phenomenon anticipated by the genetics. Dr. Carolyn Lam:               If I understand it right then, with regards to today's paper, the idea is that if a genetic predisposition to enhanced nitric oxide signaling associates with reduced risk of cardiovascular disease, then that would support the hypothesis that pharmacologic stimulation of the nitric oxide pathway would prevent or treat the cardiovascular disease, right? Could you further expand? Because you also did a meditation analysis. How would we understand that? Dr. Sekar Kathiresan:      Let me walk you through the basics of this paper. Our hypothesis initially was a genetic predisposition to enhance nitric oxide signaling would actually affect a range of cardiovascular diseases. Nitric oxide is a well-known molecule, a regulator of a number of important processes; vascular tone, blood pressure, platelet aggregation.                                                 A couple of important genes in the nitric oxide pathway are, one, nitric oxide synthase, the key enzyme that generates NO. Second is a soluble guanylyl cyclase that is a regulatory molecule involved in NO biology. One of the genes that is part of that pathway is called GUCY183, which is basically a subunit of the soluble guanylyl cyclase.                                                 What we did was we looked at those two genes and asked, "Are there naturally occurring variations in those two genes that actually give us a sense that they gain function that they actually activate nitric oxide signaling. It turned out there are two polymorphisms. One in nitric oxide synthase and the other is in the soluble guanylyl cyclase subunit that are essentially gain of function. They're common polymorphisms.                                                 We know their gain of function because the carriers of these DNA variants have lower blood pressure. An indicator that there's enhanced NO signaling. We use these two polymorphisms as an instrument to understand the phenotypic consequences of having lifelong enhanced nitric oxide signaling.                                                 What we looked at was the relationship of individuals who carried both of the gene variants or gained a function and asked whether these individuals what the relationship of carrying the variant was to a range of cardiovascular diseases as well as a range of quantitative traits like blood pressure or kidney function.                                                 We looked at this in extremely large human population samples where genotype and phenotype had been collated. Most important of these samples is a recent study of a population-based cohort study called the UK Biobank, which has involved about a half million people where genotype and have phenotype have been assembled.                                                 What we found was that genetic predisposition to enhance nitric oxide signaling was associated with reduced risk of several important cardiovascular diseases. First, coronary heart disease. Second, peripheral arterial disease, and third, ischemic stroke.                                                 That provide a very compelling evidence that atherosclerotic cardiovascular disease would be lower based on enhanced nitric oxide signaling. What was surprising to us is we also found a couple of other diseases where it seemed to benefit from enhanced nitric oxide signaling namely kidney function and pulmonary function. These were a little surprising to us, but I think it really suggest that NO plays an important role in a range of diseases.                                                 In terms of your question about what aspect of NO biology is leading to be relationship to these diseases, is it simply the blood pressure effect for example or could you actually infer a mechanisms beyond the blood pressure? We looked at that specifically in the context of cardiovascular disease and we're able to show that the protection afforded by the enhanced nitric oxide signaling gene variants, that protection exceeded the amount predicted by the blood pressure change. In fact, by quite a bit suggesting that there are probably non-blood pressure mechanisms that are at play in terms of the protection afforded by enhanced nitric oxide signaling gene variants. Dr. Carolyn Lam:               Peipei, I have to invite your thoughts now. This is such an amazing paper. We had great discussions as an editor team. Tell us your thoughts. Dr. Peipei Ping:                 The editorial team as well as the reviewers have been very impressed with the quality of the datasets and the value and detail, the metadata analysis together with the appropriate analytical approach. The study is done in our view in a very careful manner and the analysis was performed through the highest standards.                                                 What we also recognized is the potential impact that this particular study may have on multiple areas of studies, in particularly with their findings, the spectrum of individuals, how they carry nitric oxide signaling trends. You could appreciate that the individual score or genetic score paired with the analysis of the genetic variance that they have done, they see from the mental idea that examine both genetic as well as phenotype of each individual is critically important for medicine to be prescribed in the next step of therapies. Dr. Carolyn Lam:               Building on that thought, Sekar, could I ask you? You found some rare inactivating variance. Are these the patients then you think should be targeted for NO enhancing therapies? What's the clinical implications of your findings? Dr. Sekar Kathiresan:      I think there are two ways to think about the implications of these findings. One is there's just a simple biologic insight, the pharmacologic activation of NO signaling maybe protective beyond pulmonary hypertension. As you know, there are actually compounds in the clinic right now that are pharmacologic activators of soluble guanylate cyclase. Those medicines work in the rare condition of pulmonary hypertension.                                                 our work suggest that those medicines are likely to work in a broader range of indications including atherosclerotic cardiovascular disease, kidney disease and pulmonary function. At a simple level, those experiments, I think, should be looked at. Those indications should be looked at.                                                 Whether we've identified a subset of a population that particularly will respond versus it will be a general phenomenon across a range of different individuals that have impaired nitric oxide signaling, I think time will tell. Certainly, one group to think about would be those who are indigenously deficient in nitric oxide signaling and we did find that there are small subset of patients who have inactivating mutations in these two genes and they have higher blood pressure and increased risk for cardiovascular disease.                                                 It was a pretty rare phenomenon, so very small number of individuals would be relevant there. I'm not sure actually that you necessarily want to limit the potential benefit of NO signaling, enhanced NO signaling to just that subgroup. In fact, my prediction would be that the medicine would be relevant for a very large percentage of the population. That you do not need to limit the potential application of this therapy to just those who carry the inactivating mutations. Dr. Peipei Ping:                 I agree largely of what Sekar has discussed. I would add that in situations where genetic information are available with the patients, what the study has offered is fairly clear in the patients where rare variance that inactivate the NOS3 or the guanylyl cyclase off the genes. Maybe a failure it is with a higher systolic blood pressure risk. I'm entirely supportive with the general conclusion that we have come to a time point where NOS outside signaling activation is a critical new element of therapy in cardiovascular health and disease. Dr. Sekar Kathiresan:      Thank you Peipei. Thank you Sekar for taking the time to share your thoughts with us. We are so proud to be publishing paper in circulation. So proud and happy to be chatting about this on this podcast. You've been listening to Circulation on the Run. Thank you for joining us and please tune in again next week.

Runified Podcast host Matt Sorenson reflects on common themes that were present throughout the last 30 episodes of the Runified Podcast. He focuses the topics of the Boston Marathon, training, diversity, veterans, overcoming obstacles, epic adventures, and changing lives with running. This is a great chance to learn what Runified is all about! Our guests in the past 30 episodes are Audrey Springer, Victoria Phillippi, Chris Sanders, Shawanna White, Deyl Kearin, Stacy Holden, Sasha Wolff, Ben Jacobs, Kim Eagle, Arne Robertson, Marcel van der Kuil, Steph Cash Hogan, Martinus Evans, Bill O’Shields, Kate McKenzie, Martin Parnell, Thom Singer, BethAnn Telford, Ben Luke Smith, Nico Ericksen-Deriso, Mark Sutcliffe, Martina O’Connell, Bonnie Yesian, Eric Spears, Zuleyma Chazari, Adele Garcia, and Andy Cloud. We chat about the marathon, half marathon, ultramarathons, trail running, injury, training, running advice, coaching, challenges in life, mental health, education, technology, nutrition, and more.   This episode is hosted by Matt Sorenson and is sponsored by goodr. Use code “runified2017” at playgoodr.com for a special Runified discount and to help support Runified and our running podcast! Runified’s Website, Instagram, Facebook, Twitter

Kim Eagle is a nutrition coach, helping athletes across the world reach their fitness and nutrition goals with her Earn That Body programs. Kim became a runner a couple years before her son was born. After training for marathons by herself for years, she found that training with a coach and group enabled her to reach new levels. We talk with Kim about how she became a nutrition and fitness coach and how she has turned her love for fitness and nutrition into a thriving business. We talk about nutrition for long distance runners and Kim provides very helpful advice for runners of all abilities. Kim provides a special offer for our listeners you won’t want to miss.   This episode is hosted by Matt Sorenson and is sponsored by goodr. Use code “runified2017” at playgoodr.com for a special Runified discount and to help support Runified and our running podcast!   Runified’s Website, Instagram, Facebook, Twitter Earn That Body Website, Earn That Body Podcast, Protein Powder Recipe, Facebook, Instagram, Twitter

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