Podcasts about Zinn

Episode 392 of RevolutionZ  uncovers and visits a half-century-old file on my computer to address a surprisingly urgent question: are we building new revolutionary ideas, or just renting space in inherited ones. I recently rediscovered the text of my 1974 book What Is To Be Undone? written when the arguments between Marxism-Leninism, Maoism, anarchism, and other currents were not academic history but living fuel for organizing. Reading my own early investigations as the Sixties slipped into the Seventies feels like opening a time capsule and realizing the contents still impact what people believe is possible. On the same day, a friend pointed me toward Gabriel Rockhill's Who Paid The Piper Of Western Marxism? and the storms around his claim that contemporary revolutionary theory drifted into a “respectable” left alignment with capitalism and imperialism. I share a long excerpt from Rockhill laying out his case: a purge of dialectical and historical materialism, class analysis pushed aside by culturalism, and a call to rebuild a disciplined, organized left that can actually win. We agree on the need to rejuvenate anti-capitalist, anti-imperialist struggle, but we very seriously diverge on whether the path forward is a return to classical Marxism-Leninism and democratic centralism or a break from their limits. From there, I grapple with a personal and political test: was my younger and then on-going self part of the problem Rockhill describes, or was I trying to learn from past failures to strengthen future movements. Along the way I revisit blurbs from Noam Chomsky, Howard Zinn, and Herb Gintis, reflect on the dangers of sectarian dismissal, and end with Bob Dylan's “My Back Pages” as a reminder that clarity sometimes comes from letting go of certainty. This episode begins another sequence of episodes whose number of entries depends on what seems the case. Me then and now: a deluded, deceived, sell out CIA symp rejector of Marxism Leninism, or me then and now a sincere whipper snapper  trying to overcome past ideological problems on the way to a better society? Is our ideological problem anti anti imperialism, as Rockhill asserts, or is it that  in going forward from the Sixties we actually retained too much from dead men's minds? This episode is a scene setting opening shot on the way to aggressively and hopefully definitively determining which way we need to orient our thinking Back to classical Marxism Leninism, or forward to a participatory self managing future.Support the show

The Remarkable thing about Ray Zinn is he is a walking library. In this Tough Things First Podcast Ray takes your questions. Watch Now! Rob Artigo: This is a special edition of the Tough Things First podcast where we are also on video. If you want to watch instead of just listen, you can navigate to toughthingsfirst.com. On the pull down […]

6/1/26 Watermelon Wednesdays w/Paul Newlin & world-renown musician Corey Pesaturo: a preview of this week's amazing concert. Writers Block w/ Megan Zinn & Ruth Ozeki: “The Typing Lady and Other Fictions”— a preview of her upcoming event at the Odyssey Bookshop, in conversation with Kelly Link Senator Jo Comerford: the Protect Act, ICE in Massachusetts & the legislative process—getting it right. Mayor GL Sciarra of Northampton: the schools, the budget, the fiscal stability plan, & an override in our future?

Send us Fan Mail On this episode, I'm joined by Rutgers Athletic Director Kelli Zinn to talk about leading a Big Ten athletic department through the most chaotic era college sports has ever seen. We talk NIL, revenue sharing, the House settlement, the future of Olympic sports, why Rutgers is betting big on revenue generation, and how to win in college sports when the rules keep changing. Thank you for listening! For the latest in sports law news and analysis, you can follow Gabe Feldman on twitter @sportslawguy .  

Lischka, Gregor www.deutschlandfunkkultur.de, Zeitfragen

Dr. Deb Muth 00:04What if the future of healing isn’t about replacing cells, but about teaching your body how to heal itself again? We keep hearing the words stem cells and exoomes thrown around like they’re interchangeable, but they’re not. One is regulated, controversial, and often misunderstood. The other is rapidly emerging as one of the most exciting communication systems in human biology. Dr. Deb Muth 00:33And here’s the real question no one’s asking. Are we actually regenerating tissue or are we just stimulating the body to remember how it used to heal? Tired of being told your labs are normal, but you still feel terrible? At Serenity Healthcare Center, we don’t chase symptoms. We find the root cause. hormones, gut health, autoimmune conditions, chronic fatigue, brain fog. Dr. Deb Muth 01:02We use cuttingedge functional and regenerative medicine to get you real answers and a real path forward. This isn’t your average doctor’s office. This is medicine the way it was meant to be practiced. You deserve to feel like yourself again. Visit serenityhealthcarecenter.com to book your appointment today. Let us help you heal from the inside out. Dr. Deb Muth 01:28Welcome back to Let’s Talk Wellness Now. I’m Dr. Deb, your host. And if you’ve been following regenerative medicine, you’ve probably noticed the confusion. Patients are asking me every week, are exoomes stem cells? Are stem cells legal in the United States? I heard the FDA is shutting down all these clinics. Can I even get this therapy? Do I have to leave the country for treatment? Today, we’re cutting through the noise. This episode is not hype. Dr. Deb Muth 01:54It’s not sales. It’s education so you can understand the science, the regulatory reality, and the clinical difference between stem cell therapy and exoome therapy. And here’s what I want you to know right up front. Yes, these therapies are being used in the United States every single day. Yes, they’re being offered by highly trained physicians in integrative and regenerative medicine clinics across the country. Dr. Deb Muth 02:22Some are being used in FDA registered clinical trials. Some are being used in observational studies and some are being used in clinical practice under physician discretion. The landscape is nuanced and you deserve to understand it. So, grab your cup of coffee or tea and settle in for a deep dive into the most understood therapies in regenerative medicine. Dr. Deb Muth 02:43what they actually are, how they work, the regulatory landscape, and how they might support your body’s natural healing capacity. Let’s talk wellness now. So, let me start by asking you something. When you hear the word stem cell, what do you picture? Most people imagine damaged tissues magically regenerating or a torn meniscus growing back, cartilage reforming it into an arthritic joint or damaged brain tissue being replaced with healthy new beautiful cells. It’s a beautiful vision. Dr. Deb Muth 03:15And while it’s not quite that simple, the reality is actually more sophisticated and honestly more beautiful. Stem cells are powerful and they absolutely work, but the way they work and the mechanism by which they support healing is far more elegant and more so than most people really understand. And if you’re going to invest in regenerative therapy, you deserve to understand what you’re actually receiving. Dr. Deb Muth 03:44So, let’s start at the beginning. What are stem cells? At their core, stem cells are undifferentiated cells. That means they haven’t yet decided what they want to be when they grow up. Unlike a heart cell or a skin cell or a bone cell which have already committed to a specific function, stem cells exist in this beautiful state of potential. Dr. Deb Muth 04:05They have two remarkable abilities. First, they can self-renew. They can make copies of themselves, maintaining a reserve of these powerful cells throughout your lifetime. Second, they can differentiate under the right conditions. They can transform into specialized cell types. Bone cells, cartilage cells, nerve cells, muscle cells, even blood cells. Dr. Deb Muth 04:27This is why they’ve captured the imagination of the medical world. The potential is extraordinary. Now, there are several types of stem cells and understanding the differences matters tremendously for both understanding how they work and understanding how they’re regulated. Adult mezzenymal stem cells. We call these MSC’s are the most commonly used regenerative medicine. Dr. Deb Muth 04:54These come from bone marrow, atapost tissue, that’s fat, and other adult sources. They’re what we can call multi-potent, meaning they can become several types of cells, but not every type. A bone marrow stem cell isn’t going to become a brain cell, for instance. It has potential but it’s directed potential. Dr. Deb Muth 05:19Then we have perinatal stem cells. These come from umbilical cord blood cord tissue or something called Wharton’s jelly which is the gelatinous substance inside the umbilical cord. These cells are younger, more potent, and research by Weiss and colleagues published in stem cells back in 2006 showed that Wharton’s jelly derived MSC’s have superior proliferation and differentiation potential compared to bone marrow derived cells. Dr. Deb Muth 05:48They’re like comparing a 20-year-old athlete to a 50-year-old athlete. Both can perform, but one has more reserve capacity, more vigor, and more regenerative potential. And this isn’t this is very important because the perinatal sources umbilical cord tissue Wharton’s jelly amniotic tissue these are what many regenerative medicine clinics in the United States are using today and they’re using them because these tissues are incredibly rich in not just stem cells but growth factors cytoines and exoomes. Dr. Deb Muth 06:21Then there are embryionic stem cells. These are pur potent and they become any cell type in the body, but they’re highly regulated, ethically controversial, and honestly, they’re not being used in clinical practice in the United States outside of the very specific FDA approved research trials. Dr. Deb Muth 06:41So, when clinics talk about stem cell therapy, they’re almost never talking about embryionic stem cells. Now, here’s where it gets interesting and this is the part that changes everything about how we understand regenerative medicine. When you receive stem cell therapy, let’s say someone injects umbilical cord derived messenymal stem cells into your arthritic knee, those cells do not typically engraft or become new tissue in any permanent way. Dr. Deb Muth 07:12They don’t set up shop in your joint and start cracking out new cartilage cells for the rest of your life. So what are they actually doing then? Well, in 2011, researchers Arnold Arnold Kaplan and Dennis Korea published a landmark paper in stem cells translational medicine that fundamentally changed how we understand MSC therapy. Dr. Deb Muth 07:35They proposed that we should stop calling memal stem cells and start calling them medicinal signaling cells. Why? Well, because their primary therapeutic benefit doesn’t come from what they become. It comes from what they secrete. Think of stem cells as incredibly sophisticated biological pharmacies. When you inject them into damaged tissue, that arthritic knee, that inflamed autoimmune condition, that injured brain, that don’t just sit there passively, they sense the environment. Dr. Deb Muth 08:07They detect inflammation. They recognize the tissue damage and they understand that the immune dysregulation is present and they see that and respond. They start pumping out hundreds of bioactive molecules, growth factors that tell your cells to repair and rebuild, cytoines that modulate inflammation, chemocines that recruit your body’s own healing cells to the area. Dr. Deb Muth 08:32And these tiny membranes bound packages called extracellular vesicles, including exosomes, which we’re going to talk about extensively today as well. These secreted factors are giving instructions to your native cells. They’re saying, “Let’s reduce inflammation. Let’s modulate your immune response. Let’s promote angioenesis. Dr. Deb Muth 08:53” That’s the formation of new blood vessels, bringing nutrients and oxygen. Let’s stimulate your own resident stem cells to wake up and get to work. Reduce cell death in damaged tissue and restore normal cellular function. This is called paracrine signaling. It’s the cellto cell communication. And this is where the real therapeutic power lives. Dr. Deb Muth 09:14The stem cells themselves, many of them die within days to weeks, but the cascade of healing they trigger, the signals they send, the programs they activate in your own cells, those effects can last for months or even years. Now, this understanding is crucial because it explains why both stem cell therapy and exoo therapy can be effective. Dr. Deb Muth 09:38The stem cells are powerful not because they become new tissue but because of the signals they send and exoomes are those signals isolated and concentrated. The biggest misconception in regenerative medicine is that stem cells replace tissue and in reality they coach healing more than they become healing. They’re biological educators teaching your body to remember how it used to heal before chronic inflammation, toxicity, and disease turned off all those programs. Dr. Deb Muth 10:12So if stem cells don’t exactly end graft and become the new tissue, if their power is in their signaling and then next logical question is why do we need the cells at all? Well, if we could isolate the messengers themselves, what if we could deliver just the communication systems without any of the complexity of the living cells? Well, that’s exactly what exosomes are. Dr. Deb Muth 10:38And they represent the cutting edge of regenerative medicine. So, let me paint you a picture of how cells actually communicate. Because for most medical history, we had it wrong. For decades, textbooks taught us that cells talk to each other in two basic ways. through direct contact like shaking hands or releasing signaling molecules that floated through the extracellular space like messages in bottles, simple chemical messages. Dr. Deb Muth 11:09But in the 1980s and 90s, researchers started discovering something far more sophisticated. cells were releasing these tiny membrane bound packages like a biological FedEx envelope kind of you know it was filled with complex specific cargo and these packages could travel through the blood cross the barriers that normally keep things out like bloodb brain barrier and deliver their contents to distant cells with remarkable precision. Dr. Deb Muth 11:38These are called extracellular vesicles. And exoomes are one of the most therapeutic important types. So what exactly are exosomes? Well, they’re nanosized vesicles, typically 30 to 150 nanome in diameter. To put that into perspective, a human hair is about 100,000 nanometers wide. These are incredible and most impossibly tiny. Dr. Deb Muth 12:09They’re released by virtually all cells in the body, but the most therapeutically interesting exoomes come from mezenymal stem cells. And those medicinal signaling cells we just discussed. And according to a landmark review of Raposo and Stervogal, they published in the journal of cell biology in 2013, exoomes are not cellular debris. They’re not waste products. Dr. Deb Muth 12:35They are precisely engineered communication vesicles or vehicles. Think of them as sophisticated delivery systems carefully packed, carefully labeled, and sent to specific destinations. very specific instructions. Inside each of these exoomes, you’ll find an incredibly sophisticated payload. They are microRNAs. These are small RNA molecules that can literally turn genes off or on in the recipient cells. Dr. Deb Muth 13:06They can tell a cell to start making more collagen, to reduce inflammatory proteins, to activate repair programs that have been shut down by chronic disease for a very long time. There are messenger RNAs, actual templates for protein production. And exoome can deliver these instructions for making healing proteins. There are proteins themselves, growth factors, cytoines, enzymes, all the molecular tools a cell needs to heal. Dr. Deb Muth 13:34And there are lipids, specialized fats that help the exoome membrane fuse with targeted cells, delivering the cargo inside. When an exoome reaches its target cell, it can either fuse the cell membrane and deliver its contents directly inside like a Trojan horse, or it can bind to surface receptors and trigger signaling cascades, setting off a chain reaction of healing responses. Dr. Deb Muth 14:01Either way, it’s delivering very specific targeted instruction. And here’s what makes this so powerful. Those instructions are tailored to what this recipient cell actually needs. So, let me give you some concrete examples of what the research actually shows because this is where it really gets exciting. When researchers inject MSC derived exoomes into hearts that had experienced eskeeia, reprofusion, injury, that’s damaged blood flow being cut off and then being restored. Dr. Deb Muth 14:36Kind of like what happens during a heart attack. Something remarkable happened. A study by Lei and colleagues published in stem cell research in 2010 showed that exoomes significantly reduced the size of the damaged area, reduced inflammatory cytoines that drive tissue destruction and promoted tissue repair signaling. The exoomes were telling the heart cells stop the inflammatory cascade, activate your survival programs and repair the damage. Dr. Deb Muth 15:06In cartilage research, tow and colleagues published work in biioaterials in 2017 showing that exosomes derived from MSC’s could promote cartilage regeneration in osteoarthritis models. And the exoomes carried specific microRNAs that told condondroytes cartilage cells to proliferate and make more extracellular matrix, the structural framework of healthy cartilage. Dr. Deb Muth 15:30for autoimmune conditions. Research by Blazic and colleagues in Frontiers in Immunology in 2014 demonstrated that MSC derived exoomes could shift immune cell behavior from pro pro-inflammatory to regulatory. They could take an overactive self-attacking immune system and restore balance and promote tolerance. And perhaps most exciting brain research, a study by Zinn and colleagues published in the journal of extracellular vesicles in 2013 showed that MSC derived exoomes could cross the bloodb brain barrier. Dr. Deb Muth 16:07That protective shield around your brain that normally keep things out and promote neurological recovery in stroke models. They reduced brain inflammation, promoted neuroplasticity, supported the formation of neural connections, and for mitochondrial dysfunction, which underlies so many chronic conditions, Morrison and colleagues published research and scientific reports in 2017 showing that MSC derived exoomes can actually deliver functional mitochondria or mitochondrial components to damaged cells. They’re not Dr. Deb Muth 16:40just sending instructions, they’re sending spare parts. They’re restoring the cellular powerhouses to produce energy. So why are exoomes fundamentally different from stem cells? Well, exoomes contain no living cells. They can’t replicate. They can’t end graph. And they have virtually no risk of immune rejection or tumor formation. Dr. Deb Muth 17:03Concerns that exist elevate rarely with cellular therapies. They’re essentially biological software updates for your cells. As Fineian Pitiger wrote in their seinal review in stem cells in 2017, MSC derived exoomes represent the active ingredient of stem cell therapy delivered in a cellfree format. That’s the key insight in the in the therapeutic benefit of stem cells and it comes from what they excrete. Dr. Deb Muth 17:33Then exoomes are the secretion isolated, concentrated, and standardized. From a practical clinical standpoint, exoomes offer several compelling advantages. First, consistency. Because exoomes can be isolated, characterized, and standardized, each dose can be remarkably consistent. With living stem cells, there’s variability based on donor age, health status, processing methods, and one batch may be robust, but another might be weaker. Dr. Deb Muth 18:05With exoomes, you can measure the content, measure the potency, and ensure the quality control. Second is storage. Exoomes can be liophalized. They can be freeze-dried and stored at room temperature or refrigerated for extended periods. Stem cells require cryopreserv preservation, careful freezing, careful thawing. They’re fragile. Dr. Deb Muth 18:31Exoomes are remarkably stable. And third, their safety profile. Without living cells, the risk of adverse imunological reactions is dramatically lower. You’re not introducing foreign cells that your immune system might recognize and attack. You’re introducing molecular messages. Fourth is scalability. You can harvest millions, even billions of exoomes from stem cell cultures without ever injecting the cells themselves. Dr. Deb Muth 19:01And you can produce large quantities, standardize them, and make them available to patients. Now, there is a caution here in doing this. The scalability can produce rogue cells, and we want to be cautious of that. So, here’s what I need you to understand. Exoomes don’t force healing. They remind the body how healing works. Dr. Deb Muth 19:24They’re not replacing damaged cells. They’re re-educating the cells you already have. They’re turning back time on the biological programs that got turned off by inflammation, toxicity, trauma, time, and chronic disease. Your body knows how to heal. It’s done its entire life. Every cut that closed, every bone that mended, every infection you fought off, your body orchestrated that healing. Dr. Deb Muth 19:51The problem is that chronic disease, chronic inflammation, toxic exposures, poor nutrition, stress, all of these things disrupt the communication networks that coordinate healing. And exoomes restore that communication. They’re like rebooting a computer that’s frozen. They reset the system and remind it how it’s supposed to function. All right. Dr. Deb Muth 20:14So, this would not be complete if we didn’t talk about regulation because this is where a lot of confusion exists. And I want you to be given a real picture. Not fear-mongering, not pretending. There aren’t regulatory considerations, but the actual practical reality of how regenerative medicine is practiced in the United States today. Dr. Deb Muth 20:38Here’s what you need to understand. The FDA regulates these therapies and they have specific frameworks, but there’s important nuances between regulatory text enforcement priorities and actual clinical practice. And there are also state level regulations that provide additional pathways. The FDA regulates human cells, tissues, and cellular and tissue based products. Dr. Deb Muth 21:05We call them HCT/PPS under two main pathways. Section 361 products are those that meet specific criteria. They’re minimally manipulated, intended for homologous use, meaning these tissues perform the same basic function in the recipient as it did in the donor. They’re not combined with non-tissue components and they’re either autotogus, meaning they come from your own tissue, or they have had minimal systemic effect. Dr. Deb Muth 21:38An example of a clear 361 procedure, your doctor harvests your own bone marrow, we call this PRP, performs minimally processing to or uh perform Yeah. performs minimal processing to concentrate the stem cells through a centriuge and injects it into your arthritic knee the same day. That’s autogus same day but minimally manipulated. Dr. Deb Muth 22:04This is unquestionably legal and is being done in regenerative medicine clinics across the country every single day. So there’s section 351 where products are those that don’t meet all the section 361 criteria. They’re classified as drugs or biologic products and they require FDA approval through clinical trials. Dr. Deb Muth 22:27Now here’s where this gets more nuanced. There are regenerative medicine clinics across the United States using stem cell and exoome therapies in different contexts. First FDA registered clinical trials. These are formal research studies with investigational new drug applications. Patients enroll in trials. They sign informed consents. Dr. Deb Muth 22:48They receive therapies as part of their structured research protocols. And this is completely legal and represents the gold standard for gathering evidence. Second is observational studies and registry programs. Many clinics are collecting systemic data on patient outcomes using these therapies even outside the FDA trials. Dr. Deb Muth 23:12They’re documenting results, tracking safety, and contributing to the growing body of clinical evidence. Third, there’s clinical practice under physician discretion. There are physicians using these therapies based on their own clinical judgment informed consent from patients and their interpretation of the regulatory framework particularly around minimal manipulation and homologous use. Dr. Deb Muth 23:34Now there are also state regulations that provide additional legal frameworks. So, for example, Florida has enacted the Right to Try Act and specific regenerative medicine legislation that allows physicians to offer certain stem cell therapies under the state oversight. Utah has passed similar legislation creating pathways for regenerative medicine products. Dr. Deb Muth 23:57And these state laws recognize that patients should have access to potentially beneficial therapies, particularly when used by trained physicians with appropriate informed consent. The regulatory question often centers around are these products minimally manipulated. Some products clearly are not. They’ve been cultured. Dr. Deb Muth 24:20They’ve been expanded in laboratories and those require FDA approval that they don’t have. The FDA has appropriately shut down clinics using those products. But there are other products that undergo processing that many physicians and manufacturers argue constitutes minimal manipulation. And these tissues are cleared, potentially fragmented or particulated to make them more suitable for injection, preserved using methods like cryopreservation or liophalization and packaged. Dr. Deb Muth 24:54But the cells are not cultured or expanded in the laboratory. The FDA has issued guidance suggesting that many of these processing steps constitute more than manipul minimal manipulation. But many physicians, particularly those who specialized in regenerative medicine for years, disagree with that interpretation and they believe that the processing qualifies as minimal manipulation and that the product should fall under section 361 when used for homologous purposes. Dr. Deb Muth 25:24Is there regulatory debate? Absolutely. The FDA and some clinicians have different interpretations of what constitutes minimal manipulation. But here’s the practical reality. There are hundreds of well-trained, bore certified physicians across the United States offering these therapies every single day. Dr. Deb Muth 25:42They’re doing so based on their understanding of the regulations, their clinical experience, their commitment to patient safety, and their belief that these therapies can help people who have exhausted conventional options. The FDA’s enforcement priorities have focused primarily on the most problematic cases. Clin clinics making blatant disease cure claims, products with documented safety issues, clear cases of cellular expansion and culture, or clinics operating with no medical oversight. Dr. Deb Muth 26:15Reputable regenerative medicine physicians are using products from companies that provide comprehensive documentation of their processing methods. third-party sterility testing, certificates of analysis showing bioactive content, and quality control measures that meet or exceed industry standards. Now, let me be very clear about something. Dr. Deb Muth 26:36Quality matters enormously. Not all stem cells and exoome products are created equal. Research by Burger and colleagues published in the Orthopedic Journal of Sports Medicine in 2021 analyzed 12 commercially available stem cell products and found that many contained zero viable cells, high levels of bacteria, endotoxins and inconsistent growth factor concentrations. Dr. Deb Muth 27:01This is why the company providing these biologic matters tremendously. You want products from manufacturers who provide transport documentation in sourcing and processing. Conduct third-party testing and sterility and potency. Offer certificates of analysis for each batch. Use standardized validated processing protocols. Dr. Deb Muth 27:24Have quality control measures that ensure consistency and don’t make outrageous cure claims or promise. The best regenerative medicine physician carefully vet their suppliers. They don’t use products from companies making unrealistic promises. They use products from manufacturers who are transparent, scientifically rigorous, and committed to quality. Dr. Deb Muth 27:46Now, you specifically ask about homologous use and collagen defects. So, let me address this directly for you. Under the FDA guidance, homologous use means the tissue performs the same basic function in the recipient as in the donor. So for connective tissue, tendons, ligaments, cartilage, fascia, all of that which are collagenrich structures using MSC’s or their derivatives could be considered homologous use. Dr. Deb Muth 28:17MSC’s in their native environment provide structural support to produce extracellular matrix including collagen. Using them to support healing in damaged collagen rich tissues like arthritic joints, torn tendons or degenerative ligaments is arguably the same basic function. So using exoomes derived from MSC’s to support collagen synthesis reduce inflammation and promote tissue healing in the same structures. Dr. Deb Muth 28:46Many practitioners argue this also qualifies as homologous use because you’re supporting the structure and function that MSC’s would naturally support. So here’s the bottom line on the regulatory reality. Regenerative medicine is available in the United States. It’s being offered by highly trained physicians in integrative and regenerative medicine clinics across the country. Dr. Deb Muth 29:11Some therapies are offered in FDA registered clinics and some are offered in observational studies. Some are offered in clinical practice under physician discretion, informed consent, and careful attention to safety. The regulatory landscape is evolving. There are ongoing discussions both federally and state levels about creating clearer pathways for these therapies. Dr. Deb Muth 29:32So, if you choose to go down this road, you want to work with physicians who understand the regulations, who use quality products from reputable manufacturers with rigorous testing and documentation, who are transparent about what they’re using and why, who discuss the current regulatory landscape honestly with you, and who prioritize your safety and truly informed consent above all else. Dr. Deb Muth 29:55This is not a lawless wild wild west. But it is also not as simple as everything is legal and unavailable. It’s a nuanced landscape that requires ethical knowledge. And these practitioners that have this knowledge have got to provide informed patients who understand both the potential benefits and the current regulatory context. Dr. Deb Muth 30:17So let’s have some fun here. Let’s talk about what really matters to you that are listening and that’s what conditions are being supported with these therapies. What does the research show and what are clinicians seeing in actual practice with patients? Because here’s what’s really important. We have both published research evidence and extensive clinical experience. Dr. Deb Muth 30:38And when the two align, that’s when we can feel confident and comfortable about using these approaches. So, let’s start where we have the most substantial evidence. joint health and muscularkeeletal conditions. For arthritis, we have good data. A systemic review by Tan and colleagues published in arthritis research and therapy in 2021 analyzed 20 randomized controlled trials in MSC therapy for knee osteoarthritis. Dr. Deb Muth 31:05They found significant improvements in pain and function particularly in mild to moderate disease. What’s really interesting is when researchers start analyzing whether it was the cells themselves or their secreted factors doing the work. They found that exoomeenriched preparations showed similar benefits to whole cell therapy. Dr. Deb Muth 31:26Now towen colleagues in the biioaterials paper from 2017 demonstrated that MSC derived exoomes could promote cartilage matrix synthesize and reduce inflammation markers. The exoomes carried microarnas that told cartilage cells to make more collagen and proteoglycans, the building blocks of healthy cartilage. Dr. Deb Muth 31:49In clinical practice, physicians are seeing patients with knee, hip, shoulder, and spinal arthritis, experiencing reduced pain, improved function, better motility, and in some cases, measurable improvements in their tissue. I want to share a story here with you because back in 2006, my husband was injured at work. Some of you might have heard me tell this story before. Dr. Deb Muth 32:11Um, he broke two discs in his back and underwent surgery very early on when we started using stem cells. They had put cages and plates in and they used MSC’s to put inside the cage to create a hardened bone so that he could have a fusion and hopefully not have any pain. At the time, what the physician didn’t realize or mistakenly did was he did not put any human bone mixed with these dead cadaavver bone MSC’s. Dr. Deb Muth 32:42And so the MSC’s never grew. They didn’t have anything to grow by. So the plates and the screws just kind of went back and forth for six months before he could see another physician that would look at him differently and understand what actually happened. That was very early on. Today we know so much more than we did before. Dr. Deb Muth 33:01Fast forward to 2014 when my husband was having problems and he couldn’t feel his legs, he couldn’t feel his feet. We decided to undergo uh exoo and stem cell therapy again and we saw a physician in Florida who harvested cells from his bone marrow and his blood and his fat and mixed that all together and then put that back into the back. Dr. Deb Muth 33:27and he had tremendous benefit from it. So, I tell this story because I want you to see the trajectory of how long this has been going on that we’ve been using this and we’re learning as we’re going and things are changing rapidly in this in this world. And so, what we know today and what I’m teaching you today may very well change in a month or six months or a year from now, but we have the foundation at least to understand what is helpful, what is not right now. Dr. Deb Muth 33:54But just be aware that if you’re embarking on exoome or stem cell therapy or MSC’s that you understand that this terrain is going to change. So back to my conversation about what other things can we treat? Well, we can treat tendon and ligament injuries, chronic tennis elbow, Achilles tendonopathy, rotator cuff tears, chronic planter fasciitis. Dr. Deb Muth 34:17These were researched by PA and colleagues in the American Journal of Sports Medicine in 2017 and it showed that bone marrow concentrate injections resulted in improved pain and function compared to steroid injections. Now this mechanism appears to be enhanced collagen remodeling and reduced chronic inflammation. Dr. Deb Muth 34:39These are structural collagenrich tissues using MSC’s or their derivatives for structural support which makes biological sense. It’s homologous use. It’s similar. So clinically we’re seeing athletes, active adults and people with chronic pain who failed physically um failed physical therapy, failed conservative treatments finding relief in this functional uh improvement in this functional world that we live in today. Dr. Deb Muth 35:07So, I want to be clear about what we’re doing here for joint and muscularkeeletal issues. We’re not growing completely new cartilage from scratch or severely destroyed joints. We’re not magically regenerating tissues that’s been gone for decades. That’s not possible here. What you’re doing when you’re using MSSE’s and exoomes is supporting the body’s natural ability to repair, reducing inflam inflammation and damage, and we’re driving progressive degeneration uh or we’re stopping the progressive degeneration. By reducing the Dr. Deb Muth 35:41inflammatory damage, we’re stimulating resonant stem cells that have been dormant. We’re improving blood flow and uh uh oxygen to the tissues like cartilage and tendons. and we’re organizing the body to start creating its own quality collagen as it heals. So, it’s a regenerative support, not a tissue replacement. Dr. Deb Muth 36:07But for many people, this support is lifechanging. So, let’s talk about autoimmune disorders now because this is one of the most exciting and unrecognized applications. autoimmune conditions like rheumatoid arthritis, lupus, MS, Crohn’s disease, ulcerative colitis, Hashimoto’s, they all involve the immune system and the immune system is deregulated. Dr. Deb Muth 36:30And so basically your immune system is seeing this tissue as foreign and it’s attacking it. These MSC’s and their exoomes have profound immune modulatory properties. They don’t suppress the immune system like steroids or imunosuppressive drugs. They modulate it helping to restore balance. So for rheumatoid arthritis, research by Weang and colleagues in stem cells translational medicine in 2016 showed that MSC derived exoomes could shift the balance of immune cells, reducing pro-inflammatory TH7 cells that drive joint disruption uh and increase Dr. Deb Muth 37:08regulatory TE-C cells that maintain immune tolerance. So for MS, a clinical trial by Kasus and colleagues published in archives of neurology back in 2010 evaluated autotogus MSC therapy and MS patients and they found evidence of reduced disease activity, improved neurological function and decreased inflammatory uh lesions on MRI scans. Dr. Deb Muth 37:34The proposed mechanism is MSC’s and their exoomes reduce inflammatory cytoine production promote regulatory imu immune populations support remination of damaged nerves that is rebuilding the protective coating around the nerve fibers and it reduces bloodb brain barrier permeability which prevents immune cells from attacking their brain and spinal cord. Dr. Deb Muth 38:02And so for inflammatory bowel disease, the research by Barnholm uh sorry Barnhorn and colleagues in gut in 2020 showed that MS cell MSC derived extracellular vesicles could support mucosal healing and reduce inflammation in the gut lining. They appeared to restore intestinal barrier function, healing that leaky gut and modulating local immune responses. Dr. Deb Muth 38:30So in clinical practice, physicians are seeing patients with autoimmune conditions, experiencing reduced disease flares, decreasing the need for imunosuppressive medications, improving energy and quality of life, and in some cases extending periods of remission. But here’s what I want you to understand. Dr. Deb Muth 38:52When you see these therapies for autoimmune conditions, we are supporting immune regulation and reducing inflammatory damage. We are not treating or curing the disease in a conventional sense. These therapies work best as part of a comprehensive functional medicine approach that also addresses gut health because 70% of your immune system lives in your gut and environmental triggers like mold, heavy metals, chemical toxins that can drive autoimmune responses, chronic infections that can trigger immune disregulation, stress and nervous system imbalance. And Dr. Deb Muth 39:29these nutritional deficiencies are necessary to help improve the immune function. So regenerative therapy without addressing root causes is like bailing water out of your boat without plugging the hole. You might get temporary relief, but the underlying problem still remains. So let’s talk about neurological conditions. Dr. Deb Muth 39:52And this is where the science gets truly fascinating. for traumatic brain injury and concussion. Research by Zang and colleagues in the Journal of Neurot Trauma in 2015 showed that MSC derived exoomes could reduce brain inflammation, promote neuroplasticity, that’s the brain’s ability to rewire itself and improve cognitive outcomes in animal models. Dr. Deb Muth 40:17The exoomes crossed the bloodb brain barrier, delivered neuroprotective proteins and microRNAs. They reduced inflammation, supported mitochondrial function in injured neurons and promoted both new blood vessels from new blood formation and neurogenesis and the birth of new neurons occurred. Neurological recovery requires a multi-systematic approach. Dr. Deb Muth 40:42Exoomes may support neural repair, but they work best combined with hormone optimization, growth hormone, testosterone, thyroid, pregnnolone, mitochondrial support compounds like NAD, CoQ10, PQQ, carnitine, all of those things that we use traditionally in functional medicine. Now for stroke recovery, there was research by Zinn and colleagues in the journal of extracellular vesicles that showed MSC derived exoomes reduced the size of brain damage and improved neurological recovery in animal models. There was a Dr. Deb Muth 41:19Parkinson’s disease study done by Kimoji and colleagues in the movement disorders in 2018 that suggested that MSSE derived exoomes could support dopamineergic neuron survival and those are the cells that die in Parkinson’s and it can help to reduce neuroinflammation. Clinically, physicians are seeing improvements in patients with postconussion syndrome, chronic traumatic brain injury, early stage cognitive decline, and other neurodeenerative conditions. Dr. Deb Muth 41:52These are not cures, but meaningful improvements in cognitive function, mood, energy, and quality of life. Now, let’s talk about autism spectrum disorder very carefully here because this is a very sensitive but very important topic for families. There have been several clinical trials that have explored MSC therapy for autism. Dr. Deb Muth 42:16Liv and colleagues published research in stem cell translational medicine in 2013 showing improvements in social interaction, communication, and behavioral symptoms in children with ASD who received cord blood MSC’s. Dawson and colleagues in 2017 conducted randomized trial autotogus cord blood infusion and found modest improvements in social communication particularly in children with higher baseline immune dysregulation. Dr. Deb Muth 42:47The proposed mechanisms for modulation of neuroinflammation support the mitochondrial function because many children with autism show evidence of mitochondrial dysfunction, reduction of oxidative stress, improvement in gut brain access dysfunction and modulation of immune dysregulation. In clinical practice, some physicians are seeing improvements in some children, better eye contact, increased language development, reduced sensory sensitivities, improved social engagement, but responses vary significantly, and we cannot predict which children will benefit most. So for Dr. Deb Muth 43:26families considering regenerative approaches for autism, these therapies are supporting the body’s healing mechanisms, reducing neuroinflammation, supporting cellular energy production, modulating immune function. These should only be considered as part of a comprehensive biomedical approach that includes dietary interventions to address food sensitivities, support gut health, environmental toxin removal, particularly heavy metals and chemical exposures, gut healing protocols with targeted probiotics and nutrients, Dr. Deb Muth 44:00metabolic testing and targeted supplementation, and evidence-based on behavioral and developmental therapies. These therapies should only be pursued with practitioners who are honest about what we know and what we don’t know and who follow rigorous safety protocols who never promise cures and who view regenerative medicine as a tool in the comprehensive healing strategy, not a standalone miracle. Dr. Deb Muth 44:26Not only that, these therapies will most likely need to be given several times over the course of this person’s lifetime, possibly even on an annual basis. And this is really important because it is not a oneandone. It is not a one-sizefits-all, and it needs to be looked at as a long-term option for working with autism. So, since we’re looking at stem cells versus exoomes, living cells, with stem cell therapy, you’re receiving living cells that can survive in your body for days to weeks. Dr. Deb Muth 45:02With exoome therapy, there are no living cells, just biological messages they would have sent. So, replication stem cells can potentially replicate. Although therapeutically this happens minimally, exoomes cannot replicate. They deliver the cargo and then they are cleared by your body. With stem cells, it’s primarily paracrine signaling. Dr. Deb Muth 45:28They’re coaching your cells to heal. With exoomes, it’s pure signaling, pure reprogramming your cells without any cellular component. Stem cells as we talked about can be autotogus from your own bone fat, blood or um bone marrow or allergenic from umbilical cord tissue or Wharton’s jelly. Dr. Deb Muth 45:50Exoomes are typically derived from cultured MSC’s often from umbilical cord or bone marrow sources and both can be given by local injection for targeted treatment of joints and tissues and exoomes can be given intravenously for whole body systemic support. both have um low immun immunogicity. I can’t say that word today. Dr. Deb Muth 46:17But exoomes have even lower risk since they contain no cellular material. Now, it’s absolutely critical for you to understand that there are massive quality differences. We’ve talked about this earlier. I want you to be very aware of this and have a conversation with any of the practitioners that you’re considering undergoing this treatment with. Dr. Deb Muth 46:37Here is where it matters more than anything when you’re considering regenerative medicine, the quality of the products and the expertise of the practitioner. Because the reality is not all regenerative medicine products are created equal. We all know that when we take different supplements and not all practitioners understand these therapies at the same depth. Dr. Deb Muth 46:58You want to look for practitioners that are board certified or have some kind of specialized regenerative medicine training. You want to know their clinical experience. How much have they done these procedures? How long have they done this? You want honest communication about the evidence and the limitations in this. Dr. Deb Muth 47:17You want a comprehensive functional medicine approach to go along with these therapies. And you want somebody that’s transparent about their informed consent and their regulatory status. If you have people that are uh claiming that they can cure disease or giving you guarantees, that is not that is not a good practitioner to work with. Dr. Deb Muth 47:37If you have high pressure sales tactics, you need to decide today limited supply for a week. These are marketing manipulations. It’s not medical care. You want to be cautious of extremely low prices because quality regenerative products are expensive to source, process, and test. and store. And if somebody’s offering stem cells or exoomes for a few hundred dollars, seriously, you need to question the quality, the safety, and where they got this from. Dr. Deb Muth 48:09So before undergoing any regenerative therapy, make sure you’re having a very, very lengthy conversation with the person and so you truly understand exactly what you’re getting, how it’s going to be delivered, and what they’re going to do. If there’s one thing I want you to take away from today is that your body has remarkable capacity to heal when given the right biological signals and the right environment. Dr. Deb Muth 48:35Stem cells and exoomes are powerful tools for providing biological signaling that can reduce inflammation, modulate immune function, support tissue repair, and restore cellular communication that’s been disrupted by chronic disease and inflammation. These therapies are available in the United States through trained physicians working in FDA registered trials, observational studies, and clinical practice, and using quality products from manufacturers with rigorous testing and quality control. Dr. Deb Muth 49:04So before you invest in regenerative medicine, do your homework. Ask detailed questions about product quality and source. Verify the products come from reputable manufacturers with certificates of analysis, third-party testing. Work with experienced practitioners. And remember, no injection, no infusion, no biologic can overcome ongoing toxic exposure, chronic stress, poor nutrition, gut dysfunction, and inadequate sleep. Dr. Deb Muth 49:34True healing requires your body and you to actively participate in this healing. If you are unwilling to address the root causes and change the lifestyle factors that disrupted your health in the first place, the biologics can amplify your healing signals, but you have to create the internal environment where healing can actually happen. Dr. Deb Muth 49:56So, I hope this episode has helped you understand regenerative medicine more clearly. Share it with somebody who’s looking for healing beyond the conventional approaches. And until next time, this has been Let’s Talk Wellness Now. Have a blessed day. >> Welcome to Let’s Talk Wellness Now, where we bring expert insights directly to you. Dr. Deb Muth 50:16Please note that the views and information shared by our guests are their own and do not necessarily reflect those of Let’s Talk Wellness Now, its management, or our partners. Each affiliate, sponsor, and partner is an independent entity with its own perspectives. Today’s content is provided forformational and educational purposes only and should not be considered specific advice, whether financial, medical, or legal. Dr. Deb Muth 50:41While we strive to present accurate and useful information, we cannot guarantee its completeness or relevance to your unique circumstances. We encourage you to consult with a qualified professional to address your individual needs. Your use of information from this broadcast is entirely at your own risk. Dr. Deb Muth 51:00By continuing to listen, you agree to indemnify and hold Let’s Talk Wellness Now and its associates harmless from any claims or damages arising from the use of this content. We may update this disclaimer at any time, and changes will take effect immediately upon posting or broadcast. Thank you for tuning in. We hope you find this episode both insightful and thought-provoking. Listener discretion is advised.The post Episode 265 – The Future of Healing: How Exosomes Re-Educate Your Body to Heal Itself first appeared on Let's Talk Wellness Now.

5/18/26 (Co-Host Megan Zinn) The three not so little bears in Bill's neighborhood. Dr. David Gottsegen on plastics in our food and water. Megan Zinn with Katie DeBonville on “Grace Notes: A Musical Memoir.” Andrew Zimbalist, Smith Prof and sports expert: the World Cup coming to Mass -- an economic boondoggle? Michael Klare, Five College Prof Emeritus of Peace & World Security Studies: War and Peace (?) -- China, Iran, Cuba & Ukraine.

Wer alte Zinnkrüge zum Wertstoffhof trägt, weiß, dass sie einem heute aus der Hand gerissen werden. Der Zinnpreis ist parallel zum Gold in den letzten Jahren erheblich gestiegen. Aber was kann dieses sehr biegsame Schwermetall eigentlich und wofür wird es vor allem in den Böden, von der Pflanze, den Tieren und vom Menschen gebraucht? Darüber unterhält sich Eva Schmidt wieder mit Dr. Stefan Hügel, er ist Bioverfahrenstechniker und engagiert für einen gesunden Boden. Mehr über seine Arbeit erfahren Sie unter almaterra.at

Steve Pikiell discusses how he shaped his '26-27 roster with the guidance and efforts of Athletic Director Keli Zinn and General Manager Rob Sullivan. He also discusses how recruiting in the portal is constantly evolving, roster retention, recruiting size and rebounders, and how he plans to fill his remaining roster spots.

7/27/26: Co Host: Megan Zinn Tony Giardina w/ Francis DeBernardo: New Ways Ministry and Catholics for Inclusion. Megan Zinn w/ Emma Copley Eisenberg: “Fat Swim.” Prison Policy Initiative's Mike Wessler: the Just Income Program & $445 billion/yr to lock people up. Amherst Town Mgr Paul Bockelman: Hampshire Coll closing, the budget & ed funding.

On this episode Daniel Zinn (General Counsel, Chief of Staff, and Corporate Secretary at OTC Markets Group) discusses the expanding role of the modern general counsel. Dan shares how his role has evolved organically from pure legal counsel to encompass strategic business partnership, operational leadership, and business development. The conversation explores how Dan's multi-faceted role allows him to be involved in strategic discussions from the ground up, rather than just solving problems after they arise.

This time of year, many people around the world celebrate renewal, rebirth, and transformation. In this Tough Things First podcast, Ray Zinn digs into his book Zen of Zinn Daily to say, “you can do better. Here's how.” Rob Artigo: Ray, as we record this, it's March 31st, 2026. Your new book, Zen of Zinn Daily, compiles the best of your […]

A Suite of Choices 3/30/26: David Roitman (Co-Lead, UU Democracy Action Team) & Prof Danielle Allen on “Reimagining Democracy,” abolishing partisan primaries, legislators' stipends, applying the Public Records Law to them & same day voter reg. Megan Zinn's Writers Block w/ Jessica Brilliant Keener: “Evening Begins the Day.” Easthampton Mayor Salem Derby: No Kings, Mount Tom, antisemitism in schools—the City's response & DESE's report, the budget, schools & an impending override? Rob Weir: “7 Swings at 7: Mickey Mantle—Legend and Victim of American Culture.”

Odysseys 3/23/26: Tara Brewster & Susan Nicastro: Big Brothers/ Big Sisters & karaoke at the Iron Horse. Akemi Kochiyama-Ladson, Co-Director, Yuri Kochiyama Solidarity Project: resilience & resistance. Megan Zinn w/ Mark Oppenheimer on “Judy Blume, a Life.” Ellen Meeropol, on “Sometimes an Island.” Amherst Town Mgr Paul Bockelman: his Executive Order on immigration enforcement.

In this conversation, G'Ade and Mr. Ray Zinn discuss the critical role of active listening in leadership. They explore how effective communication fosters trust within teams, especially during conflicts, and the importance of empathy in understanding different perspectives. Mr. Zinn shares insights from his experience as a long-serving CEO, emphasizing that listening is essential for decision-making and cultivating a positive organizational culture. The discussion also highlights the need for emerging leaders to master listening skills to enhance their effectiveness and the overall success of their teams.To Connect with Ray Zinn:https://toughthingsfirst.com/To Connect with G'Ade:https://linktr.ee/theunfilteredbygade

Neighborism 3/16/26: Olivia Aguilar, MHC Prof & Dir of Miller Worley Ctr for the Environment: “A Latine Outdoor Experience.” Megan Zinn w/ Anne Fadiman on “Frog and Other Essays” coming to Broadside. Oscars Recap & Reactions w/ Megan Zinn & Kerstin Nordstrom. MA LUCE Immigrant Justice Hotline w/ Lena Entin & Michael Kaine.

Neighborism 3/16/26: Olivia Aguilar, MHC Prof & Dir of Miller Worley Ctr for the Environment: “A Latine Outdoor Experience.” Megan Zinn w/ Anne Fadiman on “Frog and Other Essays” coming to Broadside. Oscars Recap & Reactions w/ Megan Zinn & Kerstin Nordstrom. MA LUCE Immigrant Justice Hotline w/ Lena Entin & Michael Kaine.

Ray Zinn is not just the Longest Serving CEO in Silicon Valley History, he's a man that does not retire or quit. In this special edition of the Tough Things First Podcast, Ray talks about his new book aimed at inspiring the next generations to do the same. One day at a time. Zen of Zinn Daily is 365 days […]

Doing and Undoing 3/9/26: Country Joe remembered. Megan Zinn w/ Lindy West: her on-the-road memoir “Adult Braces.” Megan Zinn w/ political novelist Ellen Meeropol: “Sometimes an Island,” – life after the Undoing. Holyoke Mayor Joshua Garcia: silenced sirens & Holyoke's Irish tradition. UMass Middle East Prof David Mednicoff: the Iran War, nukes & int'l law.

Doing and Undoing 3/9/26: Country Joe remembered. Megan Zinn w/ Lindy West: her on-the-road memoir “Adult Braces.” Megan Zinn w/ political novelist Ellen Meeropol: “Sometimes an Island,” – life after the Undoing. Holyoke Mayor Joshua Garcia: silenced sirens & Holyoke's Irish tradition. UMass Middle East Prof David Mednicoff: the Iran War, nukes & int'l law.

Dr. David Zinn is the Director of Sport Management at Lander University in South Carolina along with being the NCAA Faculty Rep for their student athletes. Dr. Zinn stops by the podcast to share an update and some observations on this episode of The Educational AD Podcast!

TOP: Rutgers AD Keli Zinn on fundraising, RAC renovation, RU’s hoops programs and much more 23:50 Seton Hall-UConn fallout 29:55: Mid-major & D-3 shout-outs 34:15: Happy 80th, Pops Carino

Dateline New Haven: City Engineer Giovanni Zinn by WNHH Community Radio

You might not think so, but interviewing a candidate for a job is not easier than being interviewed. In this Tough Things First podcast, Ray Zinn explains the process from both sides. Rob Artigo: This is a quote from page 46 of Zen of Zinn, your book, page 46, and here it is: “When looking for a job, are you […]

What's Cooking? 2/16: Elyse Moore --"Jolly Good Time in the Kitchen" GCC Senior Symposia Wednesday, 2/18, at 2pm Writers' Block w/ Megan Zinn & acclaimed Lauren Groff about her new book Brawler MHC Kerstin N. Nordstrom with MHC Astronomy Prof. Ben Boatwright — Colonizing Mars? Really? Mandi Jo Henneke — Amherst Town Council president on budgets, schools, housing, and charter change.

2/9/26: Megan Zinn w/ Broadside's Roz Kreshak-Hayden: books to read & indies to support. Writers Block w/John Sayles's on “Crucible,” Henry Ford, industrial policy & his antisemitism. Holyoke Mayor Joshua Garcia: Bad Bunny, schools, MTA negotiations, icy roads, state aid, & financial modernization. John Bonifaz, Pres & Founder of Free Speech for People: prosecuting ICE agents, the AG, DAs, & the police.

SUPPORT VIVA! GET MERCH! www.vivafrei.com BUY A BOOK! https://amzn.to/4qBXikS SEND ME SOMETHING! David Freiheit 20423 SR 7 Ste F6319 Boca Raton 33498 TIP WITH CRYPTO! bc1qt0umnqna63pyw5j8uesphsfz0dyrtmqcq5ugwm THAT IS ALL! ----- The Justice Centre for Constitutional Freedoms (JCCF) is a Canadian non-profit legal advocacy organization founded in 2010 that defends constitutional rights and freedoms through litigation and education, often focusing on cases involving free speech, personal liberties, and challenges to government overreach (e.g., related to COVID measures and the Freedom Convoy).

2/2/26: John Bollard: “Two Hundred Years of Protesting with Rosa Parks.” Megan Zinn w/ Bremond Berry MacDougall & Lisa Endo Cooper: publishing “lost” women authors. Sen. Jo Comerford: combatting ICE's harms in Mass & nationwide & state finances. Nmpton Mayor GL Sciarra: If ICE comes to Hamp, snow removal, art & artists -- David Rothstein, ice sculptures & the Silver Chord Bowl,

Taken from a page of Ray's book Zen of Zinn 3, in this Tough Things First podcast, Ray Zinn discusses how honest assessment is the difference between gambling and investing. Rob Artigo: Ray, let's turn to page 89 of Zen of Zinn 3, your book in the series of three books. Page 89, and this is what it said, very […]

In which the laws of the Forgotten Realms get dicey

Send us a text✨  Dakota Zinn, Director of Partnership Solutions @ Kansas City Chiefs☁️ Building, fostering, and leveraging relationships in your career☁️ How to ask for and create your own opportunities☁️ The impact of Taylor Swift on the Chiefs' audience and partnerships☁️ Behind the scenes of partnership marketing☁️ Tips for getting promoted in sports marketingJoin the Sky Society Women in Marketing private LinkedIn group.Follow Sky Society on Instagram @skysociety.co and TikTok @skysociety.co

Ray Zinn, the longest-serving CEO in Silicon Valley history, joins the show to share the discipline required to lead a company for 37 years. From his roots as the oldest of 11 on a cattle ranch to inventing the Wafer Stepper and co-founding Micrel, Ray's journey is a masterclass in grit. We discuss the "boot camp" phase of starting a business, the benefits of self-financing, and his "Tough Things First" philosophy—learning to love the tasks you hate to overcome adversity. Whether you're a veteran entrepreneur or a corporate leader, Ray's insights on risk, profitability, and leadership will challenge you to sharpen your focus and tackle your biggest challenges head-on. Episode Resources: Tough Things First Zinn Starter   About Our Guest Raymond D. Zinn is an inventor, entrepreneur, and the longest serving CEO of a publicly traded company in Silicon Valley. Zinn is known best for conceptualizing and in effect inventing the Wafer Stepper, and for co-founding semiconductor company Micrel (acquired by Microchip in 2015), which provides essential components for smartphones, consumer electronics and enterprise networks. He has served as Chief Executive Officer, Chairman of its Board of Directors and President since the Company's inception in 1978. About Our Sponsors Navy Federal Credit Union   Navy Federal Credit Union offers exclusive benefits to all of their members. All Veterans, Active Duty and their families can become members. Have you been saving up for the season of cheer and joy that is just around the corner? With Navy Federal Credit Union's cashRewards and cashRewards Plus cards, you could earn a $250 cash bonus when you spend $2,500 in the first 90 days. Offer ends 1/1/26. You could earn up to 2% unlimited cash back with the cashRewards and cashRewards Plus cards. With Navy Federal, members have access to financial advice and money management and 24/7 access to award-winning service. Whether you're a Veteran of the Army, Marine Corps, Navy, Air Force, Space Force or Coast Guard, you and your family can become members. Join now at Navy Federal Credit Union. At Navy Federal, our members are the mission.      Join the conversation on Facebook! Check out Veteran on the Move on Facebook to connect with our guests and other listeners. A place where you can network with other like-minded veterans who are transitioning to entrepreneurship and get updates on people, programs and resources to help you in YOUR transition to entrepreneurship.   Want to be our next guest? Send us an email at interview@veteranonthemove.com.  Did you love this episode? Leave us a 5-star rating and review!  Download Joe Crane's Top 7 Paths to Freedom or get it on your mobile device. Text VETERAN to 38470. Veteran On the Move podcast has published 500 episodes. Our listeners have the opportunity to hear in-depth interviews conducted by host Joe Crane. The podcast features people, programs, and resources to assist veterans in their transition to entrepreneurship.  As a result, Veteran On the Move has over 7,000,000 verified downloads through Stitcher Radio, SoundCloud, iTunes and RSS Feed Syndication making it one of the most popular Military Entrepreneur Shows on the Internet Today.

Taking Time 1/12/26: Amherst author Jill Shulman: choosing a college & taking time to tell them who you are. Megan Zinn w/ Jedediah Berry, author of “The Naming Song,” winner of the 2025 Mass Book Award for Fiction –a decade to write. Holyoke Mayor Joshua Garica, Treasurer Rory Casey & Councilor Megan McGrath-Smith: years to change the 1879 law. UMass Prof Amilcar Shabazz: years later, are we honoring MLK's legacy?

The Urgency of Now 1/5/26: Bob Flaherty: Trump, the invasion, protests & rewilding. Megan Zinn w/ Margot Douaihy: “Divine Ruin,” third in the Sister Holiday mystery series. At-large Amherst Councilor Mandi Jo Hanneke: buy the numbers. Nation Magazine Defense Correspondent Michael Klare: Venezuela & beyond.

12/29/25: Gwen Agan: the view from the principal's office and the school committee. Megan Zinn, Lee Thomson & Alice Hough:” Whatcha reading?”—fantasies to consider. Lucia Dostal—an amazing musician—in studio! Thomas Draudt: “Conversations on Main”— Picture Main St.

In the volatile world of Silicon Valley, where the average CEO tenure is often less than five years and startups burn out as quickly as they rise, Ray Zinn stands as a monumental exception. For 37 years, Zinn served as the CEO of Micrel, the semiconductor company he founded in 1978, holding the record as the longest-serving CEO of a publicly traded company in the Valley. His tenure wasn't just about longevity; it was a masterclass in disciplined consistency. Under his leadership, Micrel achieved a staggering record of being profitable for 36 out of those 37 years, a feat almost unheard of in the tech industry.This video dives deep into the story of the man they call the "Iron Man" of the semiconductor industry. We explore how Zinn famously rejected the standard Venture Capital model, choosing instead to bootstrap Micrel using his own savings and bank loans to maintain total control over the company's culture and destiny. You will learn about his unique management philosophy, "Tough Things First," which prioritized discipline and employee well-being over short-term stock manipulation.Beyond the business metrics, we also uncover the incredible personal resilience of Ray Zinn. Later in his career, he went legally blind, yet continued to run the company effectively, relying on his vivid memory and the deep trust he had built with his team. From the early days of 1978 to the final acquisition by Microchip Technology in 2015, this is the definitive story of an outlier who proved that slow, steady, and disciplined leadership can outlast the hype of Silicon Valley.Support the show

Megan Zinn w/Elinor Lipman on “Ladies in Waiting: Jane Austen's Unsung Characters.” by WHMP Radio

12.15.25 Amherst Super. Dr. Xiomara Herman—budgets, start time, and staff. Writers' Block w/ Megan Zinn & Karolina Zapal on the Book Reading Challenge. Easthampton Mayor Salem Derby—lean budgets and affordability. EMK Institute CEO Adam Hinds on polarization and the Filibuster.

Click on the podcast as newly appointed Montana State Representative Stacy Zinn joins us in studio. A longtime DEA agent and former congressional candidate, Zinn has been on the front lines battling cartels, gang crime, and the growing fentanyl threat […] The post Former DEA Agent Has New Digs for an Old Fight first appeared on Voices of Montana.

With fan frustration at a high level with both Greg Schiano and Steve Pikiell, new Rutgers AD Keli Zinn has only one realistic choice in the present. Despite some fans calling for both coaches to be fired, the most realistic plan is to generate as much NIL and resources possible to put both coaches in the best position possible to succeed in 2026. At the same time, Zinn needs to build belief and change perception with legitimate NIL resources at Rutgers to better the future of both programs long term. #rutgersfootball #rutgersbasketball

The world of information is transforming at light speed, and getting sucked into a misinformation vortex is a constant problem. In this Tough Things First podcast, Ray Zinn says, “Just the Facts, Ma'am.” Rob Artigo: Ray, looking at page 26 of your first Zen of Zinn book, Zen of Zinn one. It says, you wrote this, “Get it right and […]

Mike, Richie and Alec are joined by Rutgers Athletics Director Keli Zinn to discuss everything from RNIL, department changes, facilities, new hires, her favorite NJ foods, if Rutgers / Maryland will get a rivalry trophy and she pitches us (and you at home) why to donate! Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Mike, Richie and Alec discuss everything Keli Zinn had to say about Rutgers new NIL initiative during her media scrum today (2:00) before breaking down what Schiano had to say during his weekly presser (15:00). They close by discussing where the team is at at the halfway point of the season (29:00). Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

On today's Bible Answer Man broadcast (10/13/25), Hank discusses Columbus Day, a U.S. holiday that commemorates the landing of Christopher Columbus in the Americas in 1492. In 2020, Columbus Day was the scene of carnage as demonstrators toppled statues of Abraham Lincoln and Theodore Roosevelt in Portland's South Park Block. Moreover, the moniker “Stolen Land” was ominously spray-painted across its concrete base. Protest organizers dubbed the event “Indigenous Peoples Day of Rage.” What could possibly motivate American citizens—supposed exemplars of social justice—to behave with such wanton recklessness in a supposed era of “wokeness” and progressive values? In trying to come to grips with this question, Hank was cowed by page after page of Google search results with exclamations that Columbus was a nefarious character—a ruthless money-grubbing, genocidal maniac, who severed hands, raped women, and enslaved gentle people to satisfy white Europeans' lust for gold. One starts to wonder “how can I trust history?” Mary Grabar, author of the book, Debunking Howard Zinn: Exposing the Fake History That Turned a Generation Against America asked this very question. A good deal of what you read on the internet is based on Zinn's historical revisionism. It constitutes a steady diet of poison seeping into the hearts and minds of impressionable children. Grabar exposes the fake history lessons that are systematically turning a new generation of kids against American exceptionalism.

Charlie Kirk assassination, Las Vegas, E. Parry Thomas. Eccles family, Mormon influence in Vegas, Howard Hughes, "Mormon mafia," Mitt Romney, Huntsman family, Jon Huntsman Jr., Intertel, Resorts international, Donald J. Trump, Steve Wynn, Wynn's relationship with E. Parry Thomas, Trump's struggles breaking into Vegas, Sean Reyes, David O. Leavitt, the Kingstons, "Bleeding the Beast," Reyes and the Kingstons, pedophilia and incest among the Kingstons, "Lost Boys," Lost Boys as Vegas prostitutes, the LeBarons, the LeBaron-NXIVM connection, the "LeBaron-Langford Massacre," allegations of trafficking against fundamentalist Mormon sects, M. Russell Ballard, Timothy Ballard, Operation Underground Railroad (OUR), David Lee Hamblin, Satanic ritual abuse (SRA) allegations in Utah, George Zinn, Zinn's child porn charges, Sundance Film Festival, Utah Republican Party, Zinn as a delegate for the Utah Republican Party, Jason Chaffetz, Chaffetz's links to Utah Valley University, Chaffetz's links to Jon Huntsman, Mia Love, Mike Lee, Russell M. Nelson and his death, the Grand Blanc Township Mormon church shooting, Timothy Ballard and Israel, Erika Kirk, Erika Kirk's relationship with Trump, George Zinn and Jon Huntsman, OUR as MAGA honeypot, Trump & the LDSFirst Kirk Assassination ShowSecond Kirk Assassination ShowResourcesMusic b y: Keith Allen Dennishttps://keithallendennis.bandcamp.com/ Hosted on Acast. See acast.com/privacy for more information.

Charlie Kirk, the Kirk assassination, George Zinn, Zinn's arrest for child porn, June 14 SLC No Kings march, Armed Queers LLC, Utah County Sheriff's Department, David Lee Hamblin, Satanic ritual abuse (SRA), Hamblin's use of narco-hypnosis, David Leavitt, Ukraine, Gordon Bowen, Sundance, Robert Redford, M. Russell Ballard, Timothy Ballard, Operation Underground Railroad (OUR), Minnesota and OUR's move to, OUR's links to Ukraine, Kash Patel, Patel's links to Ballard, Richard C. O'Brien, Kirk's links to Ballard, Medvedev's Ukraine accusations, Jason Goodman, George Webb, attempts to link Ukraine to the assassination, Cambridge Analytica and its network, Russia-Israel links, intrigues in Trump 2.0, OUR as the Sword of Damocles in Trump 2.0, the similarities between Hamblin's techniques and CIA/Pentagon behavior modificationResourcesMusic by: Keith Allen Dennishttps://keithallendennis.bandcamp.com/ Hosted on Acast. See acast.com/privacy for more information.

Utah prosecutors have charged 22-year-old Tyler Robinson with aggravated murder in the shooting of conservative commentator Charlie Kirk. The charges include obstruction of justice, witness tampering, and multiple firearm offenses. According to the affidavit, Robinson confessed to both his roommate — with whom he was in a romantic relationship — and his father. Investigators say Robinson admitted that the motive was political. He told his roommate that “some hate cannot be negotiated” and accused Kirk of “spreading hatred.”Prosecutors allege that Robinson carved antifascist slogans into the bullet casings used in the shooting. They say he left behind clothes and a backpack at the scene, both of which tested positive for his DNA. A bolt-action rifle was found nearby. Surveillance footage and Discord messages allegedly link Robinson to planning the attack, though he has not spoken directly to police. His roommate, someone transitioning from male to female who has not been publicly identified, is cooperating with investigators.Politics Politics Politics is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber.Also at the scene was a second man, George Zinn, who approached police with a knife and told them to shoot him. Zinn allegedly said he had been trying to help Robinson escape. He has not been charged in the shooting, but prosecutors say he was found with child pornography. The two men were not known to each other before that day.This case does not follow the familiar patterns of mental instability or mass shooting chaos. Prosecutors have outlined what they describe as a deliberate, targeted act with ideological motivation. Robinson allegedly stated that he believed the shooting would be “the only way” to stop Kirk. The firearm used was a bolt-action rifle, which indicates planning rather than impulsivity.Governor Spencer Cox, in his television appearances, struck a more composed tone than in his initial press conference. That earlier moment felt like a political speech. Over the weekend, however, he appeared more focused on unity and de-escalation. That stands in contrast to Trump, whose responses were angrier and more inflammatory. The White House has not issued a formal statement, but administration officials have been briefed.One of the major talking points emerging in political media is whether this attack fits into a broader pattern. Names like Paul Pelosi and Ashli Babbitt have been floated — but what happened here is categorically different. The suspect allegedly had a motive, a plan, and a clear ideological framework. This was not senseless. According to prosecutors, it was intentional and politically driven.It's still early, and these are only allegations. But the details laid out so far paint a clear picture: a targeted political killing, carried out in public, with motive stated directly. That's rare. And it's something we'll be forced to grapple with as the trial unfolds.Chapters00:00:00 - Intro00:02:15 - Charlie Kirk Suspect Arrested00:09:53 - Interview with Karol Markowicz00:53:28 - Update00:54:01 - Pam Bondi Hate Speech00:57:39 - Epstein01:00:15 - Hakeem Jeffries and Zohran Mamdani01:02:53 - Interview with Ryan McBeth01:52:45 - Wrap-up This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.politicspoliticspolitics.com/subscribe

//The Wire//2300Z September 16, 2025////ROUTINE////BLUF: UKRAINIAN ATTACK REPORTED IN VLADIVOSTOK IN POSSIBLE SNEAK-ATTACK. MORE DETAILS RELEASED ON KIRK SHOOTING, MANY QUESTIONS STILL REMAIN.// -----BEGIN TEARLINE------International Events-Far East: This morning explosions were reported in Vladivostok, as Ukrainian forces allegedly conducted a strike at far-flung military installations in Russia's eastern region. The exact location of the attack(s) has not yet been confirmed, however Ukrainian sources claim that the target was the 155th Marine Infantry Brigade.Analyst Comment: So far most of the sources on this attack are Ukrainian, so not entirely the most impartial resources for determining what happened. This could have been another behind-the-lines drone attack such as conducted a few months ago, since this attack vector is really one of the handful of methods for targeting this far away from the current conflict zone in Ukraine.-HomeFront-Utah: George Zinn, the man who created a distraction during the Kirk assassination, has been charged with obstruction of justice after admitting that he caused the distraction intentionally. Authorities continuing the investigation have stated that Zinn stated that he intended to draw attention away from the real shooter, to allow the assassin to escape.Washington D.C. - This morning FBI Director Kash Patel testified before Congress on a variety of issues.Analyst Comment: Most of the testimony today was only remarkable for the entertainment value, though Patel did continue to raise suspicions (as has become a nearly-daily occurrence) regarding Jeffrey Epstein, stating that Epstein did not traffic anyone to other individuals.-----END TEARLINE-----Analyst Comments: Almost a week after the assassination of Charlie Kirk, the number of inconsistencies and accomplices remains the same as before. If George Zinn did not have prior knowledge of the attack (as insinuated by investigators) the initial knee-jerk reaction to help out an unknown assassin in the seconds after a brutal murder is very odd at best, or psychopathic at worst. Zinn does have a long history of agitation and mental illness, so at this point it's hard to determine if he is just crazy or a legitimate and pre-planned accomplice to the murder. This afternoon, the alleged text messages between Tyler Robinson and his transgender accomplice were released, mostly pertaining to communications between the two apparently after the attack (though no timestamps on these messages were provided). These communications (among other things) indicate that the rifle was covertly stolen from the suspect's grandfather prior to the murder.Otherwise, the tone of the messages as released is somewhat unusual, and may be an indication of a pre-established alibi, knowing that these messages would be evidence at some point. Other terminology seems suspicious, leading to concerns that the messages might be fabricated or altered in some way, a speculative theory that is backed up by the inclusion of ellipses in the provided text which confirms that parts of the conversations have been omitted before release (though to what degree remains unclear). Right now there's no way to confirm the authenticity of these messages either way, and much more information and investigation is needed to determine exactly what took place. However even without digging in to the messages, the general gist of the case so far is that it's overwhelmingly unlikely that Tyler Robinson acted alone.More broadly, the expansion of investigations into other accomplices continues, as many statements from investigators have indicated the list of accomplices is wider than previously thought (by the FBI, at least). Authorities have stated that 20 individuals are currently being investigated for having prior knowledge of the attack.Analyst: S2A1Re

//The Wire//2300Z September 10, 2025////PRIORITY////BLUF: CHARLIE KIRK ASSASSINATED AT EVENT IN UTAH. RUSSIAN DRONES ENTER POLISH AIRSPACE, SEVERAL SHOT DOWN BY POLISH AIR FORCE. VIOLENT MURDER SUSPECT REMAINS FUGITIVE IN NEW YORK. // -----BEGIN TEARLINE------International Events-Poland: Yesterday evening multiple Russian drones were observed flying out of the warzone in Ukraine and into Polish airspace. Polish military authorities issued various airspace closures and scrambled aircraft to intercept these drones. U.S. Air Force aircraft were also observed responding to the crisis, having scrambled at least one F-35 to attempt to find the drones. As the crisis developed Poland issued a large-scale shelter-in-place order, encompassing much of the eastern regions of the country, home to roughly 9 million people. No one was killed, and none of the drones appear to have been targeting anything in Poland as roughly a dozen drones were discovered crashed in farmers fields in eastern districts of the country.Analyst Comment: So far, the number of drones that entered Polish airspace has varied. Most reports seem to settle on a figure of around a dozen drones of varying type, but the true number has not been confirmed. Poland did confirm that several drones were shot down inside their airspace, though the exact number was not provided.-HomeFront-Utah: This afternoon Charlie Kirk was assassinated at a Turning Point USA event at Utah Valley University in Orem.Analyst Comment: This is a developing situation at the time of this report, and the situation remains very dynamic and multiple malign actors may be involved. After the shot, an elderly man (who was identified as George Zinn) was tackled in the crowd by those who thought he was the shooter. After some time, it became clear that Zinn was not the shooter but actually an agitator of some sort. While this is speculative, this individual behaved as though he may have been a spotter and/or an intentional distraction from the actual shooter, who may have taken the shot from an elevated position some distance away from the event. Some video evidence from the scene does indicate that an individual was spotted lying prone in a tactical position on the roof of an adjacent building. This afternoon, the FBI stated that they had one suspect in custody, other than the individual identified as George Zinn. More details to follow as information becomes available.North Carolina: Societal tensions remain extremely high following the release of the full murder tape of Iryna Zarutska. President Trump has called for the death penalty to be applied in this case, and the extremely shocking and disturbing nature of the murder is causing larger questions to be asked.Analyst Comment: In short, this horrific murder (and now along with that of Charlie Kirk) has moved the goalposts toward an acknowledgement of reality more than anything in recent memory. The defense is also trying to tee up an insanity defense, releasing statements that suggest the killer might have been mentally ill. However, the audio from the murder tape confirms that the murderer had planned and pre-established a story for the murder, stating that the victim had provoked him in some way (which the tape also confirms she did not do). Considering that the murderer will be tried by a jury of his peers probably *in Charlotte*, this is an important distinction to remember.Washington D.C. - Yesterday the Bureau of Labor Statistics posted the annual revisions to the jobs report, which revised the total number of jobs created last year. Out of the roughly 1.7 million jobs allegedly created last year, a little over 911,000 jobs were revised downwards, which is the largest recorded revision on record.Analyst Comment: This jobs report means that 51% of all of the jobs reported last year...never existed. The books were cooked to doub

//The Wire//2300Z September 11, 2025////ROUTINE////BLUF: CHARLIE KIRK ASSASSIN REMAINS AT LARGE AS THE INVESTIGATION CONTINUES. MULTIPLE HOAX SWATTING INCIDENTS REPORTED AT UNIVERSITIES AROUND THE NATION. CUBAN ILLEGAL ARRESTED AFTER BRUTAL MURDER AT DALLAS HOTEL. SHOOTING REPORTED AT US NAVAL ACADEMY IN ANNAPOLIS.// -----BEGIN TEARLINE------HomeFront-Utah: The situation regarding the assassination of Charlie Kirk continues to develop, with many new details coming to light overnight. At the moment, multiple individuals seem to be involved in this case in one way or another: One actual shooter, and many more persons that caused confusion during the initial reaction to the shooting. The individual identified as George Zinn was initially arrested after he verbally confessed to the crime, stating that he was the shooter. He screamed "I did it" and "shoot me" immediately as the shot was heard. This could have been a case of mental illness (as Zinn has a criminal history that reflects such and he was known to authorities for this kind of thing) or this could also have been an intentional act of diversion to allow the real shooter time to escape. Whatever the intent was, this did function as a diversionary tactic, and the shooter was able to egress from the area. Nevertheless, local reports state that Zinn was released from custody. Another unidentified individual was initially arrested at the scene as well, in possession of a pellet rifle. No further information regarding this individual's status at this time.Idaho: A fight broke out at a candlelight vigil at the Idaho Capitol (which was arranged to memorialize Charlie Kirk) when leftist activists began to interrupt proceedings. Several leftist demonstrators were removed after they attempted to gain entry to the crowd and scream obscenities during the vigil.Colorado: Yesterday afternoon a school shooting was reported at Evergreen High School near Denver. Local authorities state that Desmond Holly, a 16-year-old student at the school, shot two students before taking his own life.Texas: Yesterday afternoon a woman was beheaded at a motel in Dallas. Local authorities state that Yordanis Cobo-Martinez, an illegal migrant from Cuba, murdered his employer (Chandra Nagamallaiah) with a machete after a brief argument at the Downtown Suites Hotel. Cobo-Martinez was arrested at the scene.Maryland: This afternoon, an active shooter was reported at the US Naval Academy in Annapolis. This is a developing situation at this time, but initial reports indicate that a former Midshipmen returned to the institution to conduct the attack. Early reports indicate as many as 1-3 casualties, however the scene is still locked down at this time. More details to follow as information becomes available.USA: This afternoon the recent wave of swatting calls flared up again, with several calls being made around Boston this afternoon. An active shooter situation was reported at the University of Massachusetts (UMass), which turned out to be a hoax. Several other locations around Boston were also host to swatting incidents, which also were hoaxes. This morning a bomb threat was called in to the DNC headquarters in Washington, which was also confirmed to be a hoax. Throughout the afternoon the University of Central Florida also reported a similar hoax being called in at their campus.-----END TEARLINE-----Analyst Comments: When it comes to risk assessment and mitigation, making decisions based on details that are speculative is acceptable if time is of the essence, such as when a high-profile assassin is still on the loose. However, it would be wise to focus on the details that help with that assessment, rather than getting dragged down rabbit holes that eat up time that we don't have. Panicking helps no one, and though it is a challenging skill to develop when the general mood is that of extreme anger, rem