Podcasts about endophthalmitis

Drs. Katherine Talcott and Yoshihiro Yonekawa join to discuss four recent publications in major ophthalmology journals.Featured articles:Anti-VEGF or PRP First for PDR (https://jamanetwork.com/journals/jamaophthalmology/article-abstract/2822892)Face Down Positioning for Macular Holes (https://www.aaojournal.org/article/S0161-6420(24)00483-4/fulltext)Management of Post-Cataract Endophthalmitis (https://www.ophthalmologyretina.org/article/S2468-6530(24)00337-3/abstract)PDS Clinical Trial Results (https://www.ophthalmologyretina.org/article/S2468-6530(24)00400-7/fulltext)ReferenceMichels Retinal Detachment (referenced in podcast, https://www.amazon.com/Retinal-Detachment-Ronald-G-Michels/dp/0801634172)Relevant Financial Disclosures: Dr. Sridhar and Dr. Talcott have consulted for Apellis and Iveric.You can claim CME credits for prior episodes via the AAO website. Visit https://www.aao.org/browse-multimedia?filter=Audi

In this episode of the New Retina Radio Journal Club with VBS, Maura Di Nicola, MD; Sruthi Arepalli, MD, and Barton Blackorby, MD, discuss a recent study comparing endophthalmitis rates following anti-VEGF injections with pre-treatment using either 5% Povidone Iodine or 0.05% Chlorhexidine. They highlight how prefilled syringes can reduce the risk of endophthalmitis and explore the implications for clinical practice, including antiseptic protocols, patient sensitivities, and how to navigate conflicting study outcomes. Tune in for valuable insights that could influence your injection protocols.

Episode 445: Endophthalmitis Management Crash Course with Dr. Ajay KuriyanDr. Ajay Kuriyan joins the podcast to offer pearls and strategies for managing endophthalmitis as a retinal specialist.You can claim CME credits for prior episodes via the AAO website. Visit https://www.aao.org/browse-multimedia?filter=Audi

In this episode of Knock Knock Eye, I reflect on turning 39 and how my medical history—surviving testicular cancer and a cardiac arrest—shapes my outlook on life and birthdays. Along with these personal reflections, I answer insightful YouTube comments, discussing topics like vision requirements for driving and Halloween eyeball decorations. I also dive into one of the scariest eye conditions for both patients and surgeons: Endophthalmitis, a dangerous post-surgery infection. Takeaways: Endophthalmitis: The Scariest Eye Condition: Dr. Flannery explains why Endophthalmitis is one of the most feared post-surgical complications, highlighting its symptoms, treatment, and the potential for severe vision loss. Reflecting on 39th Birthday: Dr. Flannery shares how surviving cancer and a cardiac arrest has shaped his perspective on celebrating another year of life, with both joy and a lingering sense of caution. Vision and Driving Laws: Responding to YouTube comments, Dr. Flannery discusses the surprisingly lax driving vision requirements in some states, like Wisconsin, and the potential dangers this poses to road safety. Halloween Eyeballs and Fan Comments: On a lighter note, Dr. Flannery enjoys a fun conversation with fans about his obsession with Halloween eyeball decorations, especially painting pumpkins and using inflatable eyes to bring a spooky twist to ophthalmology. Balancing Life as a Doctor and Comedian: Dr. Flannery talks about juggling two careers—ophthalmology and internet comedy—and how both bring him fulfillment, especially when he gets to engage with fans and answer their questions. — To Get Tickets to Wife & Death: You can visit Glaucomflecken.com/live  We want to hear YOUR stories (and medical puns)! Shoot us an email and say hi! knockknockhi@human-content.com Can't get enough of us? Shucks. You can support the show on Patreon for early episode access, exclusive bonus shows, livestream hangouts, and much more! – http://www.patreon.com/glaucomflecken Also, be sure to check out the newsletter: https://glaucomflecken.com/glauc-to-me/ If you are interested in buying a book from one of our guests, check them all out here: https://www.amazon.com/shop/dr.glaucomflecken If you like the scrubs I'm wearing, here's a link and discount code to get some Jaanuu Scrubs link: https://bit.ly/4cAvXbs code: DRG20 for 20% off first-time purchases* *This code works on full-price items only excluding embroidery!  If you want more information on models I use: Anatomy Warehouse provides for the best, crafting custom anatomical products, medical simulation kits and presentation models that create a lasting educational impact.  For more information go to Anatomy Warehouse DOT com. Link:  Anatomy Warehouse Plus for 15% off use code: Glaucomflecken15 Today's episode is brought to you by the Nuance Dragon Ambient Experience (DAX). It's like having a virtual Jonathan in your pocket. If you would like to learn more about DAX Copilot check out http://nuance.com/discoverDAX and ask your provider for the DAX Copilot experience. Produced by Human Content Learn more about your ad choices. Visit megaphone.fm/adchoices

Drs. Safa Rahmani and Kat Talcott join to discuss four recent major ophthalmology papers.Culture or No Culture for Endophthalmitis (https://ophthalmologyretina.org/article/S2468-6530(24)00338-5/abstract)Risk of Retinal Tear after Cataract Surgery (https://www.aaojournal.org/article/S0161-6420(24)00392-0/abstract)AREDS2 and GA Progression (https://www.aaojournal.org/article/S0161-6420(24)00425-1/abstract)Resident Salary and Benefits (https://jamanetwork.com/journals/jamaophthalmology/article-abstract/2820695#google_vignette)Relevant Financial Disclosures: Dr. Sridhar and Dr. Talcott have consulted for Apellis and Iveric.You can claim CME credits for prior episodes via the AAO website. Visit https://www.aao.org/browse-multimedia?filter=Audi

Today we are joined by Doctor Amir Khan, a professor of ophthalmology here at the Mayo Clinic for an interactive journal club doctor Khan brought two articles to our attention:  Ophthalmology Workforce Projections in the United States, 2020 to 2035 - Ophthalmology (aaojournal.org)  Endophthalmitis rates and risk factors following intraocular surgeries in the medicare population from 2016 to 2019 | British Journal of Ophthalmology (bmj.com)    Subscribe to the podcast:  https://MayoClinicOphthalmology.podbean.com   Follow and reach out to us on X: @mayocliniceye   

Contributor: Meghan Hurley MD Educational Pearls: What is Cellulitis? A common and potentially serious bacterial skin infection. Caused by various types of bacteria, with Streptococcus and Staphylococcus species being the most common. What is Preseptal Cellulitis and why is it more serious than facial cellulitis? Preseptal Cellulitis, also known as Periorbital Cellulitis, is a bacterial infection of the soft tissues in the eyelid and the surrounding area. This requires prompt and aggressive treatment to avoid progression into Orbital Cellulitis. How is Preseptal Cellulitis treated? Oral antibiotics for five to seven days. In the setting of trauma (scratching bug bites) Clindamycin or TMP-SMX (for MRSA coverage) and Amoxicillin-clavulanic acid or Cefpodoxime or Cefdinir. If there is no trauma, monotherapy with amoxicillin-clavulanic acid is appropriate. Check immunization status against H.influenzae and adjust appropriately. What is Orbital Cellulitis, how is it diagnosed, and why is it more serious than Preseptal Cellulitis? Orbital cellulitis involves the tissues behind the eyeball and within the eye socket itself. Key features include: Eye pain. Proptosis (Bulging of the eye out of its normal position). Impaired eye movement. Blurred or double vision. This can lead to three very serious complications: Orbital Compartment Syndrome. This can push eye forward, stretch optic nerve, and threaten vision. Meningitis given that the meninges of the brain are continuous with optic nerve. Endophthalmitis, which is inflammation of the inner coats of the eye. This can also threaten vision. If suspected, get a CT of the orbits and/or an MRI to look for an abscess behind the eyes. How is Orbital Cellulitis treated? IV antibiotics. Cover for meningitis with Ceftriaxone and Vancomycin. Add Metronidazole until intracranial involvement has been ruled out. Drain the abscess surgically. Usually this is performed by an ophthalmologist or an otolaryngologist. Admit to the hospital. References Bae C, Bourget D. Periorbital Cellulitis. 2023 Jul 17. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 29261970. Chaudhry IA, Shamsi FA, Elzaridi E, Al-Rashed W, Al-Amri A, Al-Anezi F, Arat YO, Holck DE. Outcome of treated orbital cellulitis in a tertiary eye care center in the middle East. Ophthalmology. 2007 Feb;114(2):345-54. doi: 10.1016/j.ophtha.2006.07.059. PMID: 17270683. Seltz LB, Smith J, Durairaj VD, Enzenauer R, Todd J. Microbiology and antibiotic management of orbital cellulitis. Pediatrics. 2011 Mar;127(3):e566-72. doi: 10.1542/peds.2010-2117. Epub 2011 Feb 14. PMID: 21321025. Wong SJ, Levi J. Management of pediatric orbital cellulitis: A systematic review. Int J Pediatr Otorhinolaryngol. 2018 Jul;110:123-129. doi: 10.1016/j.ijporl.2018.05.006. Epub 2018 May 8. PMID: 29859573. Summarized by Jeffrey Olson MS2 | Edited by Meg Joyce & Jorge Chalit, OMSII  

In this episode, we review the high-yield topic of Endophthalmitis from the Ophthalmology section. Follow Medbullets on social media: Facebook: www.facebook.com/medbullets Instagram: www.instagram.com/medbulletsofficial Twitter: www.twitter.com/medbullets

We sit down with vitreoretinal surgeon Dr. Tim Olsen to discuss screening for fungal endophthalmitis. Where did the traditional screening dogma originate and why? What are the potential harms from excessive screening? And finally, what do we do with this information when working with other medical specialties?   Breazzano MP, et al; AAO. American Academy of Ophthalmology Recommendations on Screening for Endogenous Candida Endophthalmitis. Ophthalmology. 2022 Jan;129(1):73-76. doi: 10.1016/j.ophtha.2021.07.015. Epub 2021 Jul 19. PMID: 34293405.  Subscribe to the podcast:  https://MayoClinicOphthalmology.podbean.com  Follow and reach out to us on Twitter: @mayocliniceye 

The Journal RETINA is devoted exclusively to diseases of the retina and vitreous. These podcasts are intended to bring to its listeners summaries of selected articles published in the current issue of this internationally acclaimed journal.

The Journal RETINA is devoted exclusively to diseases of the retina and vitreous. These podcasts are intended to bring to its listeners summaries of selected articles published in the current issue of this internationally acclaimed journal.

Bascom Palmer Eye Institute is celebrating its 60th anniversary and multiple guests join to lend historical perspective on major retina advancements at the institute. Dr. Eduardo Alfonso: Introduction (3:00)Dr. John Clarkson: The Founding Five, including discussion of Dr. J. Donald Gass (9:25)Dr. Steve Charles: Development of Modern Vitrectomy Surgical Systems (23:10)Dr. Philip Rosenfeld: Using Avastin for Retinal Disease (28.02)Dr. Mary Lou Lewis: Female Surgeons Entering the Field of Retina (44:57)Drs. Harry W. Flynn Jr. and Richard Forster: Developing Modern Treatments for Endophthalmitis (52:47)Drs. Lisa Olmos de Koo and Charles Wykoff: Alumni Perspectives and What to Look For in the Future (1:07:05)

The Journal RETINA is devoted exclusively to diseases of the retina and vitreous.  These podcasts are intended to bring to its listeners summaries of selected articles published in the current issue of this internationally acclaimed journal.

The Journal RETINA is devoted exclusively to diseases of the retina and vitreous.  These podcasts are intended to bring to its listeners summaries of selected articles published in the current issue of this internationally acclaimed journal.

Cost-Analysis of Protocal AB (https://jamanetwork.com/journals/jamaophthalmology/fullarticle/2780414) Endophthalmitis after MIGS (https://www.aaojournal.org/article/S0161-6420(21)00414-0/fulltext) Gender of Award Recipients in Major Ophthalmology Societies (https://www.ajo.com/article/S0002-9394(21)00314-7/fulltext)

In this episode we speak with Quresh Mohamed, a Consultant Ophthalmologist from Cheltenham. We discuss his paper entitled, 'Post-injection endophthalmitis rates with reduced povidone-iodine prophylaxis in patients with self-reported iodine sensitivity'. --- Send in a voice message: https://anchor.fm/eyetoeye/message

Welcome to EyePod Bayer!  In the following episode we will be focusing on endophthalmitis, and we have the honor to welcome Dr Eva Olofsson from Umeå University Hospital, a vitreoretinal surgeon, and the chairman of the Swedish Society of Ophthalmology, as our expert and distinguished guest for this session. Did you like the interview? Let us know your thoughts! eyepod@bayer.com MA-M_AFL-DK-0093-1  

Welcome to the 44th episode of Snippets. For this episode we have with us Dr. Muna Bhende, Senior Consultant, Vitreo Retinal services, Sankara Nethralaya, Chennai. She shares her experience and expertise on the management of Endophthalmitis. Please submit your valuable feedback at: https://forms.gle/k7LVRkuNSFgeuib78 Follow us on Facebook:https://www.facebook.com/SNippets-106093427853136 & Twitter: https://twitter.com/SnippetsP for weekly updates!! Subscribe to our podcast on the respective platforms --- Send in a voice message: https://anchor.fm/sankara-nethralaya/message

Dr. Vander from Wills Eye Hospital discusses the effect of vitreous tap on the management of 60 cases of endophthalmitis post intravitreal anti-VEGF injections. The discussed article:  Changes in Management Based on Vitreous Culture in Endophthalmitis After Intravitreal Anti-vascular Endothelial Growth Factor Injection. Patel SN, Storey PP, Pancholy M, Obeid A, Wibbelsman TD, Levin H, Hsu J, Garg SJ, Dunn JP, Vander JF. Am J Ophthalmol. 2019 Nov;207:224-231. doi: 10.1016/j.ajo.2019.06.008. Epub 2019 Jun 13

Drs. Ajay Kuriyan and Priya Sharma Vakharia join the program for a journal club discussion of four recent publications in major ophthalmology journals: LEAVO Study Endophthalmitis after Cataract Surgery IRIS Registry study PRP in RISE/RIDE Online Content for Diabetic Retinopathy

Dr. Shriji Patel and Dr. Ajay Kuriyan join live from ASRS 2019 for a journal club discussing four recent publications in major ophthalmology journals: EMR Effects on Operating Room Time Effect of Positive Vitreous Culture on Endophthalmitis Management Intravitreal Injection Trends Among Medicare Beneficiaries Redundancy of EMR Notes

Aankhe Lalima Hone Ka Ilaj? #XzimerMedicare me aaj ke is podcast me aap janege ki iritis kya hai, Scaliritis kya hai, Epicyclitis kya hai, Endophthalmitis kya hai, inhe phchane kaise, aur inka ilaj kya hai, aur ankh me chot lagne par kya kare ye sab aap is podcast me janege................ What Causes & Treatment of Redness In The Eye? || क्या है, आँख लाल होने का कारण और इलाज? https://youtu.be/KhnW7El4Ll4 Subscribe the channel. It's free- https://www.youtube.com/channe/UC5IcI... Facebook- https://www.facebook.com/XzimerOn/ Twitter - https://twitter.com/xzimer?s=09 --- Send in a voice message: https://anchor.fm/xzimer-medicare/message

Drs. Daniel Chao and Will Parke join for a journal club discussing 3 recent published peer-reviewed articles: 27-gauge trochar IOL fixation (hyperlink:https://journals.lww.com/retinajournal/Abstract/publishahead/27_GAUGE_SUTURELESS_INTRASCLERAL_FIXATION_OF.96416.aspx) Bilateral intravitreal injections and endophthalmitis (hyperlink:https://www.ajo.com/article/S0002-9394(18)30326-X/fulltext) Protocol S predictors (hyperlink: https://www.aaojournal.org/article/S0161-6420(18)30577-3/fulltext)

Check out this bonus episode while the Journal of Emergency Medicine Podcast takes a brief spring break.  We searched the last year of JEM Journals for pertinent articles on Infectious Disease topics and put them all together for one focused audio summary.  It is a great review of some previously published excerpts plus new content as well.  Special thanks to my guests on the show, Dr. Lucy Franjic, Dr. Court Crenshaw, and Dr. Aurelia Cheng.

Dr. David Almeida discusses the result of his group's large retrospective analysis of management and outcomes of 40 cases of endophthalmitis from over 258,000 intravitreal anti-VEGF injections.  Full reference: Xu, K., Chin, E. K., Bennett, S. R., Williams, D. F., Ryan, E. H., Dev, S., . . . Almeida, D. R. P. (2018). Endophthalmitis after Intravitreal Injection of Vascular Endothelial Growth Factor Inhibitors: Management and Visual Outcomes. Ophthalmology. doi:10.1016/j.ophtha.2018.01.022

Guest: Stephen G. Schwartz, MD, MBA Associate Professor of Ophthalmology Medical Director, Bascom Palmer Eye Institute at Naples Naples, FL

Paper Discussed: Ng JQ, Morlet N, Pearman JW, et al. Management and outcomes of postoperative endophthalmitis since the endophthalmitis vitrectomy study: the Endophthalmitis Population Study of Western Australia (EPSWA)'s fifth report. Ophthalmology, July 2005, 112(7) p1199-206 Guest: Jonathon Q. Ng, MBBS, BA Research Associate School of Population Health The University of Western Australia Crawley, Australia

Thu, 14 Jan 2010 12:00:00 +0100 https://edoc.ub.uni-muenchen.de/11045/ https://edoc.ub.uni-muenchen.de/11045/1/Zahneisen_Martina.pdf Zahneisen, Martina

Auch bei Augeneingriffen sind Risiken bzw. Komplikationen möglich. Schwerwiegendste Komplikation ist wohl die Endophthalmitis, welche durch perioperativ eingeschwemmte Bakterien intraokular, entsteht. Mit dieser Studie wurde versucht, mit zusätzlich zum Standardprocedere (Iod-Povidon Waschung präoperativ) gegebenem Levofloxacin eine Verringerung der Vorderkammerwasserkontamination intraoperativ zu erreichen. Pro Gruppe (Kontroll- vs. Studiengruppe) jeweils 64 Patienten. Der Nachweis konnte nicht erbracht werden. Von den 128 intraoperativen Proben war nur eine Vorderkammerwasserprobe kontaminiert. Somit ist keine Aussage über die Wirksamkeit möglich. Jedoch wurde in einer parallel angefertigten Studie eine signifikante Verringerung der Standortflora erreicht, welche als Infektionsquelle angesehen wird. Somit ist von einem positivem Effekt auf die Vorderkammerwasserkontamination auszugehen.

Guest: Vahid Feiz, M.D. Assistant ProfessorDirector of Refractive Surgery ServicesUC Davis Medical CenterDepartment of Ophthalmology and Vision Sciences Sacramento, CA

Paper Discussed: Prajna Lalitha, Jyothsna Rajagopalan, Karthik Prakash, Kim Ramasamy, Namperumalsamy Venkatesh Prajna and Muthaiah Srinivasan Postcataract Endophthalmitis in South India: Incidence and Outcome Ophthalmology, November 2005;112(11): 1884-1889 Guest: Prajna Lalitha, MD Head of the Department of Microbiology The Aravind Eye Hospital Madurai

Trotz der üblichen prophylaktischen Maßnahmen im Rahmen der Operationsvorbereitung können Erreger nachgewiesenermassen während der Operation ins Auge gelangen. Die perioperative systemische Gabe von Imipenem kann eventuell ins Augeninnere gelangte Erreger sterilisieren, zumindest bis zu einem bestimmten Maximum an Organismen. Im ersten Teil der vorliegenden Arbeit im tierexperimentellen Modell am phaken Kaninchenauge war es möglich, sämtliche mit 100 CFU S. aureus inifizierten Augen zu sterilisieren, falls diese 8 Stunden und eine halbe Stunde vor Infektion, sowie 8 Stunden nach Infektion intravenös Imipenem erhielten. Bei einer Erregermenge von 10 000 CFU waren noch 5 von 6 Augen steril, bei 10 000 CFU nur noch 3 von 6 Augen. Weiterhin scheint es möglich, den Glaskörper durch alleinige intravenöse Imipenemgabe sterilisieren zu können, wenn eine bestimmte Anzahl von intraokulären Keimen nicht überschritten wird. Im zweiten Teil dieser Arbeit wurden Augen mit 1000 CFU S. aureus infiziert und nach 24 Stunden intravenöse Therapie mit Imipenem oder der in der EVS verwendeten Kombination Ceftazidim und Amikazin begonnen. Nach 7 Tagen waren signifikant geringere Erregermengen in den mit Imipenem behandelten Augen festzustellen, als in mit Ceftazidim und Amikazin behandelten oder der unbehandelten Kontrollgruppe. 4 von 6 mit Imipenem therapierten Augen waren zu diesem Zeitpunkt steril. Ob es möglich ist, eine Endophthalmitis in einem derart frühen Stadium zu diagnostizieren und dann intravenös ohne intraokuläre Antibiotikaeingabe befriedigend therapieren zu können ist jedoch fraglich, denn in dieser Studie waren selbst in Augen mit negativem Kulturergebniss massive Entzündungszeichen festzustellen. Im dritten Teil dieser Arbeit stellte sich die intraokuläre Eingabe von Vancomycin und Amikacin als der alleinigen systemischen Imipenemgabe deutlich überlegen heraus, sowohl im Hinblick auf Erregermengen, klinischen Verlauf und histopathologisches Erscheinungsbild. Zu einem frühen Zeitpunkt der Infektion gegeben, können intraokuläres Vancomycin und Amikacin in diesem Tierexperiment relativ klare optische Medien ohne zusätzlich chirurgische Therapie erhalten. In dem hier durchgeführten Experiment erbrachte die zusätzliche intravenöse Therapie mit Imipenem keine messbare Verbesserung gegenüber der alleinigen intravitrealen Therapie mit Vancomycin und Amikacin.

Thu, 23 Jun 2005 12:00:00 +0100 https://edoc.ub.uni-muenchen.de/3831/ https://edoc.ub.uni-muenchen.de/3831/1/Kreutzer_Thomas.pdf Kreutzer, Thomas

Stenotrophomonas maltophilia, a micro-organism which colonises plastic material was isolated in only 10 known cases of postcataract surgery endophthalmitis (PE) world-wide. We present characteristics, treatment and outcome in 26 cases of PE caused by S. maltophilia contaminated rinsing solution used during cataract surgery. Methods: 21/26 patients (81%) required pars plana vitrectomy and were treated with intravitreal, topical, subconjunctival and systemic antibiotics covering to the most likely pathogens. 2 days after surgery identification of S. maltophilia allowed change of therapy to trimethoprim/sulfamethoxazol (TMP-SMX) 960mg bid i.v. and Ciprofloxacin 400mg -750mg bid p.o. for 10 days and TMP-SMX 960mg bid p.o. and Ciprofloxacin 250mg or 500mg bid p.o. for further 20 days, complemented with i.v. Fluorcortolone and topical treatment. Vision was examined before and during, 1 and 6 months after acute PE. Results: Before cataract surgery visual acuity was

Die akute postoperative Endophthalmitis stellt eine seltene, aber die Funktion und die Integrität des Auges bedrohende Komplikation nach ophthalmochirurgischen Eingriffen, meist Katarakt-Operation, dar. Häufig wird Staphylococcus epidermidis nachgewiesen. Für die Visusprognose entscheidend sind eine prompte Diagnose und schnellstmögliche Therapieeinleitung, um eine rasche Beseitigung der Erreger und Suppression der Immunantwort zu erreichen. Für die gezielte Therapie einer Staphylococcus epidermidis-assoziierten Endophthalmitis ist die Identifikation des entsprechenden Resistenzspektrums von besonderer Bedeutung, da in letzter Zeit zunehmend Resistenzentwicklungen dieser Spezies beobachtet wurden. Der genaue Zusammenhang zwischen Virulenz und Antibiotikaresistenzmuster der koagulasenegativen Staphylokokken ist bisher unklar. Unsere Hypothese, die auf dem klinischen Eindruck bei der Versorgung von Endophthalmitis-Patienten in unserer Klinik basiert, besagt, daß resistente Keime einen schwereren Krankheitsverlauf der Endophthalmitis induzieren, und dieser somit auf einer höheren Pathogenität dieser Erreger beruhen könnte. Es liegen bisher keine Daten über das funktionelle und histopathologische Erscheinungsbild einer experimentellen Endophthalmitis in Abhängigkeit von den Resistenzcharakteristika der jeweiligen Erreger vor. In der vorliegenden Arbeit wurden in einem Tiermodell Unterschiede im klinischen und funktionellen Verlauf sowie im histopathologischen Bild einer experimentellen Endophthalmitis untersucht, die durch antibiotisch unterschiedlich empfindliche Staphylococcus epidermidis-Stämme hervorgerufen wurden. Die Beobachtung des klinischen Verlaufs der Endophthalmitis ergab keine deutlichen Unterschiede im Schweregrad der Erkrankung bezüglich des vorderen Augenabschnitts. Jedoch konnten in Hinblick auf den Zeitpunkt der Funduseintrübung Differenzen zwischen den einzelnen experimentellen Guppen aufgezeigt werden. Im Verlauf der experimentell induzierten Endophthalmitis kam es bei den partiell- und multiresistenten Staphylococcus epidermidis-Stämmen zu einem früheren Zeitpunkt zu einer stärker ausgeprägten Entzündung und zu einer früheren Eintrübung des Glaskörperraumes durch Infiltration bis hin zum Verlust des roten Fundusreflexes als bei den vollempfindlichen Staphylococcus epidermidis-Stämmen. 12 Stunden nach Inokulation der Bakterien zeigte sich in den mit partiellresistenten Staphylococcus epidermidis-Stämmen infizierten Augen ein im Vergleich zur normalen Netzhautfunktion signifikant erniedrigtes ERG. Die mit vollsensiblen und multiresistenten Stämmen inokulierten Endophthalmitis-Augen waren dieser Gruppe hinsichtlich des Erhalts der Netzhautfunktion signifikant überlegen. 30 Stunden nach Infektion konnte lediglich in den mit vollsensiblen Bakterien inokulierten Augen eine elektroretinographische Antwort der Netzhaut registriert werden. Die histopathologische Analyse trug zu der klinischen und funktionellen Beobachtung bei, daß hinsichtlich des Entzündungsgrades aller untersuchten Gewebe des Auges ein milderes Bild der Endophthalmitis in den mit vollempfindlichen Keimen infizierten Augen und eine deutlichere Desintegration der anatomischen Strukturen in den mit resistenten Staphylococcus epidermidis-Stämmen infizierten Augen resultierte. Aus dem Vergleich der klinischen, histopathologischen und elektrophysiologischen Daten ergibt sich der Eindruck, daß in einem experimentellen Tiermodell einer nicht therapierten Endophthalmitis Resistenzen bei Staphylococcus epidermidis mit einem schwereren Krankheitsverlauf assoziiert sind. Die Studie zeigt, daß antibiotisch vollempfindliche Keime einen milderen Verlauf der Entzündung induzieren als partiell- und multiresistente Stämme von Staphylococcus epidermidis. Somit scheint die Schlußfolgerung gerechtfertigt, daß die spezifische Virulenz von Staphylococcus epidermidis mit dem Antibiotikaresistenzspektrum der einzelnen Stämme korreliert werden kann.