Podcasts about impaired

Josh Potter sits down with comedian and writer Ellory Smith for a wide-ranging episode of The Josh Potter Show covering comedy, sports, influencers, bizarre news stories and the increasingly strange world of social media. Ellory talks about the pressure for comedians and writers to become influencers and her day at Chargers Training Camp. The conversation also gets into NFL players with Felonies, Hard Knocks, CTE and the ridiculous-looking Guardian caps. Josh and Ellory also react to sports betting, women's sports, Banana Ball, viral news broadcasts, a bizarre Dollar Tree story, and one truly unforgettable QVC clip. Follow Ellory - https://www.instagram.com/ellory_smith Roach Reporters: Send your stories to JoshPotterShow@gmail.com See Josh live: https://punchup.live/JoshPotter Like, Subscribe, and hit the bell so you never miss a new Roach Report. This week's episode is sponsored by Quince. Head to https://www.quince.com/potter for free shipping and 365-day returns! On the show this week: Chargers training camp NFL Guardian caps Women's baseball Banana Ball  The QVC Gaff And Much More! ★★★ This week's Intro Music: “Josh Potter Show Beat” by ⁠⁠⁠ ⁠⁠ @JaxMarcayah ⁠⁠ Outro Music: “Live From The Roach Motel (feat. Hendawg)” by Brothers ⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁨⁠⁠https://www.youtube.com/@HendawgMusic ⁠⁠⁠⁠ ⁠⁠⁠⁠ ⁠ ⁠⁠⁠⁠⁠ ★★★ See Josh Live! ALL STAND UP LINKS CAN BE FOUND HERE: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://punchup.live/joshpotter ★★★ Josh Potter:

8-11 Mitch Please Ep (#270) wkly memecast for the visually & Facebook impaired00:00:00 - 0.1 Welcome00:00:10 Intros00:02:26 Depressing NEWSMitch, Hong, SOCIALISM!, TN Justin J Pearson! TN Burchett bill bans Feds from sending $ to Flock dadgum it, many AIs escape containment, Urbana UFO, SC base named after Graham; Turkey stuffed, roasted, catering truck ruse 00:07:32 ANIMAL — booted racket tail hummingbird - closer00:08:31 NEWS End00:08:42 Quiet Michael (QM) Round 117:35 Brane Damage (BD) Round 122:53 end28:14 ES round 134:30 end34:34 QM Round 239:10 end39:00 BD Round 244:00 end51:10 ES round 257:54 end58:00 QM 3 1:02:00 end1:02:10 bD round 31:10:12 end1:10:30 ES round 31:16:20 endqm pOST WITH THE MOST 1:16:30 bD post with the MOST1:17:20 ES post with the MOSThttps://www.youtube.com/c/FacebookfortheBlindFB4tB► COME to a LIVE recording every Tuesday at 7:30p CST (♫@7:00p)Follow the link below - RSVP by email, then we send a Zoom link about an hour before the show!https://linktr.ee/fb4tb #FB4tB► Like & Subscribe! FB4tB YouTube channel: https://www.youtube.com/c/FacebookfortheBlindFB4tB► Subscribe to the FB4tB podcast HERE: https://bit.ly/3mINXct► Like FB4tB on Facebook: https://www.facebook.com/FB4TB► Follow FB4tB on Twitter: https://twitter.com/FB4tB_WasTaken► Check out another nifty visualizered FB4tB podcast episode here: https://youtu.be/9O9KVHScswUThank you for listening!#Listenable, #FB4tB, #Comedy, #memes, #TuesdayNight, #LIVE, #podcast, filmed before a Live audience

Host: Darryl S. Chutka, M.D.  Guest: Stephanie L. Grach, M.D., M.S.  Chronic fatigue syndrome is now known as myalgic encephalomyelitis. Despite this change in terminology, there's still a great deal that's not known regarding this health problem. Clinical manifestations can include severe, persistent fatigue, often with a worsening of symptoms following physical exertion. Impaired sleep, potential cognitive impairment, and possible orthostatic intolerance is also commonly seen. The exact cause remains unknown, although several proposed mechanisms have come forward. The diagnosis is based on clinical presentation. Patient management, while less than optimal, is usually limited to symptom control. This condition poses a major challenge to primary care clinicians with both establishing a diagnosis and management. To help sort out this frustrating health problem is my guest, Dr. Stephanie Grach, an internist in the Division of General Internal Medicine at the Mayo Clinic. The topic for today's podcast is Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.  Connect with us! Mayo Clinic Talks Podcast Season 6 | Mayo Clinic School of Continuous Professional Development 

Reflecting pool fiasco continues, Mitch is dead, then FUNNY, FUNNY MEMES! 0:10 Intros0:50 Depressing NEWS12:00 ANIMAL closer12:30 NEWS End13:00 Quiet Michael (QM) Round 1https://www.youtube.com/c/FacebookfortheBlindFB4tB► COME to a LIVE recording every Tuesday at 9p CST (♫@8:00p)Follow the link below - RSVP by email, then we send a Zoom link about an hour before the show!https://linktr.ee/fb4tb #FB4tB► Like & Subscribe! FB4tB YouTube channel: https://www.youtube.com/c/FacebookfortheBlindFB4tB► Subscribe to the FB4tB podcast HERE: https://bit.ly/3mINXct► Like FB4tB on Facebook: https://www.facebook.com/FB4TB► Follow FB4tB on Twitter: https://twitter.com/FB4tB_WasTaken► Check out another nifty visualizered FB4tB podcast episode here: https://youtu.be/9O9KVHScswUThank you for listening!#Listenable, #FB4tB, #Comedy, #memes, #TuesdayNight, #LIVE, #podcast, filmed before a Live audience

Send us a text and chime in!As summer comes to a close, the Prescott Valley Police Department is reminding drivers that the season's final celebrations can quickly turn tragic when alcohol is involved. Whether you're attending a barbecue, spending time outdoors, or enjoying a weekend getaway, the safest choice is to never get behind the wheel after drinking. Impaired driving remains one of the leading causes of serious and fatal crashes. Alcohol slows reaction time, impairs judgment, and reduces coordination, which puts not only the impaired driver at risk, but also passengers, pedestrians, cyclists, and other motorists. The Prescott Valley Police Department encourages everyone to plan...   For the written story, read here >> https://www.signalsaz.com/articles/prescott-valley-police-urge-sober-driving/ Check out the CAST11.com Website at: https://CAST11.com Follow the CAST11 Podcast Network on Facebook at: https://Facebook.com/CAST11AZFollow Cast11 Instagram at: https://www.instagram.com/cast11_podcast_network

Send us Fan MailColin and Russ discuss the arrest of former NFL QB and color commentator Tony Romo, who was arrested last week in Wisconsin for drunk driving.  Colin and Russ watched the body worn camera and detail their analysis of the investigation.  Did the officer have probable cause to make the arrest?  Did they violate any of Tony Romo's rights?  They also deliver their predictions of what will happen with this case.  Plus, an Is This Legal and a hilarious DCOTW.  Give a listen here!

7-28 New fake proof of life! &FUNNY MEMES! FB4tB Ep. (#268)Mitch is dead, AND alive... Schrödinger's tortise, Tates in jail :) ...0:10 Intros1:25 Depressing NEWS8:45 ANIMAL closer starring Jimothy! 10:43 NEWS end11:11 QM RD11:07:00 QM PWtM 1:08:12 BD PWtM1:09:00 ES PWtMhttps://www.youtube.com/c/FacebookfortheBlindFB4tB► COME to a LIVE recording every Tuesday at 7:30p CST (♫@7:00p)Follow the link below - RSVP by email, then we send a Zoom link about an hour before the show!https://linktr.ee/fb4tb #FB4tB► Like & Subscribe! FB4tB YouTube channel: https://www.youtube.com/c/FacebookfortheBlindFB4tB► Subscribe to the FB4tB podcast HERE: https://bit.ly/3mINXct► Like FB4tB on Facebook: https://www.facebook.com/FB4TB► Follow FB4tB on Twitter: https://twitter.com/FB4tB_WasTaken► Check out another nifty visualizered FB4tB podcast episode here: https://youtu.be/9O9KVHScswUThank you for listening!#Listenable, #FB4tB, #Comedy, #memes, #TuesdayNight, #LIVE, #podcast, filmed before a Live audience

In this episode of the Gladden Longevity Podcast, Dr. Gladden interviews Dr. Bill Rawls, who shares his transformative journey from conventional medicine to holistic healing. Bill discusses his struggles with chronic illness, particularly Lyme disease, and how he discovered the importance of cellular health and autophagy in recovery. He emphasizes the role of herbal therapies and adaptogens in promoting wellness and protecting cellular function, ultimately leading to a deeper understanding of chronic illness and aging. In this conversation, they explore the intricate connections between autoimmunity, chronic illness, and the role of microbial influences. They discuss the implications of long COVID, the benefits of adaptogenic herbs, and the importance of nervous system regulation in healing. The conversation emphasizes the need for a holistic approach to health, focusing on creating a supportive environment for healing and the potential of herbal medicine in managing chronic conditions.   For Audience Join the other 20,000+ high-performers getting weekly insights on biological reversal, exponential strategies, and Life Energy optimization→ https://start.gladdenlongevity.com/subscribe If you're ready to measure your 60+ biological ages and build a personalized reversal plan, apply for a discovery call here → https://start.gladdenlongevity.com/apply-now   Use code 'Podcast10' to get 10% OFF on any of our supplements at https://gladdenlongevityshop.com/!    Takeaways ·       Dr. Bill Rawls transitioned from conventional medicine to holistic healing due to personal health struggles. ·       Chronic Lyme disease was a pivotal point in Dr. Bill's journey, leading him to explore alternative therapies. ·       Understanding cellular health is crucial for addressing chronic illnesses. ·       Autophagy is a key process for cellular rejuvenation and health. ·       Herbal therapies can effectively support the body's healing processes. ·       Adaptogens help the body adapt to stress and promote resilience. ·       Impaired autophagy is linked to many chronic illnesses. ·       Dr. Bill emphasizes the importance of diet, sleep, and lifestyle in maintaining health. ·       Herbs can protect cells from stress and inflammation. ·       The journey of healing is often non-linear and requires exploration of various therapies. Autoimmunity may be driven by microbial invasion and immune response. ·       Long COVID symptoms could be linked to reactivation of dormant pathogens. ·       Adaptogenic herbs can support cellular health and stress management. ·       Nervous system regulation is crucial for effective healing. ·       Herbal preparations can be more effective than traditional medications. ·       Creating a healthy environment is essential for chronic illness management. ·       The body's stress response can exacerbate chronic health issues. ·       Herbs can provide a broad spectrum of benefits beyond just antimicrobial effects. ·       Education and environment play key roles in health improvement. ·       Chronic illness management requires a shift in healthcare focus.  Chapters 00:00 Dr. Bill Rawls' Journey from Conventional Medicine to Holistic Healing 05:12 Understanding Lyme Disease and Chronic Illness 10:46 The Role of Autophagy in Health and Disease 16:36 Herbal Therapies and Adaptogens in Healing 25:20 Protecting Cellular Health and Mitochondrial Function 26:20 Understanding Autoimmunity and Microbial Influence 28:02 Long COVID and Chronic Illness Connections 30:14 The Role of Adaptogenic Herbs in Healing 32:07 Nervous System Regulation and Healing 33:55 Herbal Preparations and Their Efficacy 37:54 The Broad Spectrum of Herbal Medicine 40:59 Creating a Healthy Environment for Healing 49:03 The Future of Health and Chronic Illness Management   To learn more about Dr. Bill Rawls:Facebook: https://www.facebook.com/rawlsmd/ Website: rawlsmd.com Instagram: https://www.instagram.com/rawlsmd/   Reach out to us at:    Website: https://gladdenlongevity.com/     Facebook: https://www.facebook.com/Gladdenlongevity/    Instagram: https://www.instagram.com/gladdenlongevity/?hl=en     LinkedIn: https://www.linkedin.com/company/gladdenlongevity    YouTube: https://www.youtube.com/channel/UC5_q8nexY4K5ilgFnKm7naw       Gladden Longevity Podcast Disclosures Production & Independence The Gladden Longevity Podcast and Age Hackers are produced by Gladden Longevity Podcast, which operates independently from Dr. Jeffrey Gladden's clinical practice and research at Gladden Longevity in Irving, Texas. Dr. Gladden may serve as a founder, advisor, or investor in select health, wellness, or longevity-related ventures. These may occasionally be referenced in podcast discussions when relevant to educational topics. Any such mentions are for informational purposes only and do not constitute endorsements. Medical Disclaimer The Gladden Longevity Podcast is intended for educational and informational purposes only. It does not constitute the practice of medicine, nursing, or other professional healthcare services — including the giving of medical advice — and no doctor–patient relationship is formed through this podcast or its associated content. The information shared on this podcast, including opinions, research discussions, and referenced materials, is not intended to replace or serve as a substitute for professional medical advice, diagnosis, or treatment. Listeners should not disregard or delay seeking medical advice for any condition they may have. Always seek the guidance of a qualified healthcare professional regarding any questions or concerns about your health, medical conditions, or treatment options. Use of information from this podcast and any linked materials is at the listener's own risk. Podcast Guest Disclosures Guests on the Gladden Longevity Podcast may hold financial interests, advisory roles, or ownership stakes in companies, products, or services discussed during their appearance. The views expressed by guests are their own and do not necessarily reflect the opinions or positions of Gladden Longevity, Dr. Jeffrey Gladden, or the production team. Sponsorships & Affiliate Disclosures To support the creation of high-quality educational content, the Gladden Longevity Podcast may include paid sponsorships or affiliate partnerships. Any such partnerships will be clearly identified during episodes or noted in the accompanying show notes. We may receive compensation through affiliate links or sponsorship agreements when products or services are mentioned on the show. However, these partnerships do not influence the opinions, recommendations, or clinical integrity of the information presented. Additional Note on Content Integrity All content is carefully curated to align with our mission of promoting science-based, ethical, and responsible approaches to health, wellness, and longevity. We strive to maintain the highest standards of transparency and educational value in all our communications.

Federal law could require impaired driver detection technology HR 4 full 2348 Thu, 09 Jul 2026 18:11:07 +0000 Y9kvEYCyIH0gLC94JndT7uyf4vIgVpe2 news MIDDAY with JAYME & WIER news Federal law could require impaired driver detection technology HR 4 From local news & politics, to what's trending, sports & personal stories...MIDDAY with JAYME & WIER will get you through the middle of your day! © 2025 Audacy, Inc. News https://player.amperwavepod

Nobody's watchin the State of the Union...0:10 Intros1:25 Depressing NEWS17:30 ANIMAL closer18:45 NEWS End19:00 Quiet Michael (QM) Round 120:20 (QM) Round 1, for real this timexx.xx Brane Damage (BD) Round 1...https://www.youtube.com/c/FacebookfortheBlindFB4tB► COME to a LIVE recording every Tuesday at 7:30p CST (♫@7:00p)Follow the link below - RSVP by email, then we send a Zoom link about an hour before the show!https://linktr.ee/fb4tb #FB4tB► Like & Subscribe! FB4tB YouTube channel: https://www.youtube.com/c/FacebookfortheBlindFB4tB► Subscribe to the FB4tB podcast HERE: https://bit.ly/3mINXct► Like FB4tB on Facebook: https://www.facebook.com/FB4TB► Follow FB4tB on Twitter: https://twitter.com/FB4tB_WasTaken► Check out another nifty visualizered FB4tB podcast episode here: https://youtu.be/9O9KVHScswUThank you for listening!#Listenable, #FB4tB, #Comedy, #memes, #TuesdayNight, #LIVE, #podcast, filmed before a Live audience

2-17 fire horses of falsehoods Ep. (#245)https://www.youtube.com/c/FacebookfortheBlindFB4tB► COME to a LIVE recording every Tuesday at 7:30p CST (♫@7:00p)Follow the link below - RSVP by email, then we send a Zoom link about an hour before the show!https://linktr.ee/fb4tb #FB4tB► Like & Subscribe! FB4tB YouTube channel: https://www.youtube.com/c/FacebookfortheBlindFB4tB► Subscribe to the FB4tB podcast HERE: https://bit.ly/3mINXct► Like FB4tB on Facebook: https://www.facebook.com/FB4TB► Follow FB4tB on Twitter: https://twitter.com/FB4tB_WasTaken► Check out another nifty visualizered FB4tB podcast episode here: https://youtu.be/9O9KVHScswUThank you for listening!#Listenable, #FB4tB, #Comedy, #memes, #TuesdayNight, #LIVE, #podcast, filmed before a Live audience

7-7 Ep. #264 FIGHT! I am Spartacus! & then — Funny, funny memes!0:10 Intros1:25 Depressing NEWS11:00 ANIMAL closer12:45 NEWS End13:00 Quiet Michael (QM) Round 116:53 end17:00 Tiede (TD) round 1grrrrrr....18:30 we walked Tiede!20:00 We are All Tiede Round 1, ES, QM, TCBam Bam Bigelow flaming shirt and sax25:30 end25:38 ES round 131:15 end31:31 QM Round 236:42 end37:00 We've ALWAYS All been Tiede Round 2Nana refuses to read meme (NOT!)Logan Paul, enemy of the show, in 2021Tiede, friend of the show, and all of us tonight44:00 TD's RD2 end46:03 Social Media Post of the Year candidate48:18 end ES round 248:25 QM Rd352:12 QM Rd3 end52:17 Us, Tiede Round 3, even the peanut gallery, Spartacus53:57 Tyler for the WIN!Pot roast—ain't nothing wrong with that!Italian slur!?59:50 END of Tiede's Round 3 (Ende der Runde 3)1:00:00 ES round 31:04:45 ES round 31:05:08 QM Most1:06:11 Tyler doin TD's Most, ES and NAN echoing for some reason...1:07:00 ES post with the MOSThttps://www.youtube.com/c/FacebookfortheBlindFB4tB► COME to a LIVE recording every Tuesday at 7:30p CST (♫@7:00p)Follow the link below - RSVP by email, then we send a Zoom link about an hour before the show!https://linktr.ee/fb4tb #FB4tB► Like & Subscribe! FB4tB YouTube channel: https://www.youtube.com/c/FacebookfortheBlindFB4tB► Subscribe to the FB4tB podcast HERE: https://bit.ly/3mINXct► Like FB4tB on Facebook: https://www.facebook.com/FB4TB► Follow FB4tB on Twitter: https://twitter.com/FB4tB_WasTaken► Check out another nifty visualizered FB4tB podcast episode here: https://youtu.be/9O9KVHScswUThank you for listening!#Listenable, #FB4tB, #Comedy, #memes, #TuesdayNight, #LIVE, #podcast, filmed before a Live audience

Impaired driving laws could see big changes in Saskatchewan. The provincial government is proposing a new approach which would remove criminal charges from some impaired driving offences. Tim McLeod, Minister of Justice and Attorney General, joins Evan to explain why the government made this decision and how it'll impact you on the road.

Simon Constable reports on a severe heatwave in southern France that impaired cognitive function. He shares the collective relief felt as temperatures finally dropped, allowing for clearer thinking and a return to daily domestic comfort. (2)1807 TIILSIT

Description:  Hosts Roz and Dr. Sanchez-Fueyo discuss the key articles of the July issue of the American Journal of Transplantation. [3:52] Simultaneous quantification of native human and transgenic porcine liver function in a decedent model of extracorporeal cross-circulation [12:11] Pathologic evaluation of pig kidney and heart xenografts: 2024 recommendations from the Banff Xenotransplantation Pathology Working Group [13:36] The use of a centralized normothermic preservation and assessment center to rescue kidneys declined after standard allocation [25:57] Machine perfusion modulates cold-preservation injury in kidney transplantation: IDEAL stage 4 United States population cohort study [37:05] Impaired thymic function is independently associated with an increased risk of posttransplant infections in kidney recipients

PainExam Podcast Show Notes NAD+ Supplementation in Pain and Inflammation: Hype, Hope, or Emerging Science? Hosted by: PainExam Podcast Presented by: NRAP Academy (Neuromodulation, Regional Anesthesia & Pain) Host: David Rosenblum, MD Episode Overview In this episode of the PainExam Podcast, we explore the growing interest in NAD+ (Nicotinamide Adenine Dinucleotide) supplementation and its potential role in pain management, inflammation reduction, cellular recovery, and healthy aging. NAD+ is a naturally occurring coenzyme found in every living cell and is essential for energy production, mitochondrial function, DNA repair, and cellular resilience. As NAD+ levels decline with age, chronic stress, inflammation, and disease, researchers have begun investigating whether restoring NAD+ levels may improve outcomes in chronic pain conditions and inflammatory disorders. We review the current science, discuss potential mechanisms of action, and examine how NAD+ therapy is being integrated into regenerative medicine, wellness programs, and pain management practices. What is NAD+? NAD+ is a coenzyme involved in: ✅ Cellular energy production (ATP generation) ✅ Mitochondrial health ✅ DNA repair pathways ✅ Oxidative stress reduction ✅ Neuroprotection ✅ Cellular signaling ✅ Activation of longevity-associated proteins called sirtuins Without adequate NAD+, cells become less efficient at producing energy and managing inflammation. Why Might NAD+ Matter in Chronic Pain? Many chronic pain conditions involve: Mitochondrial dysfunction Oxidative stress Neuroinflammation Peripheral and central sensitization Impaired cellular recovery Researchers hypothesize that optimizing NAD+ levels may help address several of these pathways simultaneously. Potential areas of interest include: Neuropathic Pain NAD+ may support: Nerve repair Axonal recovery Mitochondrial function within neurons Reduction of oxidative injury Inflammatory Pain NAD+ influences inflammatory signaling pathways and may help modulate: Cytokine production Immune cell activity Cellular stress responses Fatigue and Recovery Patients with chronic pain frequently report: Fatigue Brain fog Reduced exercise tolerance Poor recovery Because NAD+ plays a critical role in energy metabolism, some clinicians report improvements in energy and recovery following supplementation. Potential Mechanisms of Action 1. Improved Mitochondrial Function Mitochondria generate ATP, the body's energy currency. Reduced NAD+ levels are associated with: Cellular aging Impaired energy production Increased inflammation Supplementation may help restore mitochondrial efficiency. 2. Activation of Sirtuins Sirtuins are proteins involved in: Cellular repair Longevity Metabolic regulation Inflammation control NAD+ serves as a critical substrate for sirtuin activity. 3. DNA Repair Support NAD+ is required for enzymes known as PARPs (Poly ADP Ribose Polymerases), which participate in DNA repair processes following cellular injury. 4. Reduction of Oxidative Stress Chronic inflammation often produces excessive reactive oxygen species (ROS). NAD+ may help maintain cellular antioxidant defenses and reduce oxidative injury. Routes of NAD+ Supplementation Intravenous (IV) NAD+ Most commonly marketed in wellness and recovery clinics. Potential advantages: Direct systemic delivery Avoids gastrointestinal absorption issues Allows higher dosing protocols Potential limitations: Cost Time commitment Variable evidence base Oral Precursors Rather than NAD+ itself, many supplements provide precursors such as: Nicotinamide Riboside (NR) Nicotinamide Mononucleotide (NMN) These compounds are converted into NAD+ within the body. What Does the Evidence Show? Current evidence remains preliminary. While preclinical and mechanistic studies are promising, large-scale randomized controlled trials evaluating NAD+ specifically for chronic pain are still limited. Areas under active investigation include: Neuropathic pain Neurodegenerative disorders Chronic fatigue syndromes Recovery optimization Healthy aging Patients should understand that NAD+ therapy remains an emerging treatment rather than a standard evidence-based pain intervention. Safety Considerations Reported side effects may include: Nausea Flushing Chest tightness during rapid infusions Headache Fatigue Lightheadedness Most adverse effects appear infusion-rate dependent and can often be minimized through slower administration protocols. Patients should discuss treatment with a qualified healthcare professional, especially if they have: Cardiovascular disease Active cancer Significant medical comorbidities Clinical Pearls for Pain Physicians ✔ Consider NAD+ as a potential adjunct—not a replacement—for evidence-based pain care. ✔ Continue emphasizing exercise, sleep optimization, nutrition, behavioral health, and appropriate interventional therapies. ✔ Discuss realistic expectations with patients. ✔ Recognize that evidence continues to evolve. ✔ Focus on patient-centered outcomes rather than laboratory markers alone. Key Takeaways NAD+ is essential for cellular energy production and repair. Declining NAD+ levels may contribute to aging, inflammation, and chronic disease. Early evidence suggests possible benefits in inflammation, recovery, fatigue, and nerve health. Robust pain-specific clinical trials remain limited. NAD+ therapy should currently be viewed as an adjunctive and investigational strategy in pain management. Resources for Physicians Pain Medicine Board Preparation Prepare for the ABA Pain Medicine Boards with:

    PainExam Podcast Show Notes NAD+ Supplementation in Pain and Inflammation: Hype, Hope, or Emerging Science? Hosted by: PainExam Podcast Presented by: NRAP Academy (Neuromodulation, Regional Anesthesia & Pain) Host: David Rosenblum, MD Episode Overview In this episode of the PainExam Podcast, we explore the growing interest in NAD+ (Nicotinamide Adenine Dinucleotide) supplementation and its potential role in pain management, inflammation reduction, cellular recovery, and healthy aging. NAD+ is a naturally occurring coenzyme found in every living cell and is essential for energy production, mitochondrial function, DNA repair, and cellular resilience. As NAD+ levels decline with age, chronic stress, inflammation, and disease, researchers have begun investigating whether restoring NAD+ levels may improve outcomes in chronic pain conditions and inflammatory disorders. We review the current science, discuss potential mechanisms of action, and examine how NAD+ therapy is being integrated into regenerative medicine, wellness programs, and pain management practices. What is NAD+? NAD+ is a coenzyme involved in: ✅ Cellular energy production (ATP generation) ✅ Mitochondrial health ✅ DNA repair pathways ✅ Oxidative stress reduction ✅ Neuroprotection ✅ Cellular signaling ✅ Activation of longevity-associated proteins called sirtuins Without adequate NAD+, cells become less efficient at producing energy and managing inflammation. Why Might NAD+ Matter in Chronic Pain? Many chronic pain conditions involve: Mitochondrial dysfunction Oxidative stress Neuroinflammation Peripheral and central sensitization Impaired cellular recovery Researchers hypothesize that optimizing NAD+ levels may help address several of these pathways simultaneously. Potential areas of interest include: Neuropathic Pain NAD+ may support: Nerve repair Axonal recovery Mitochondrial function within neurons Reduction of oxidative injury Inflammatory Pain NAD+ influences inflammatory signaling pathways and may help modulate: Cytokine production Immune cell activity Cellular stress responses Fatigue and Recovery Patients with chronic pain frequently report: Fatigue Brain fog Reduced exercise tolerance Poor recovery Because NAD+ plays a critical role in energy metabolism, some clinicians report improvements in energy and recovery following supplementation. Potential Mechanisms of Action 1. Improved Mitochondrial Function Mitochondria generate ATP, the body's energy currency. Reduced NAD+ levels are associated with: Cellular aging Impaired energy production Increased inflammation Supplementation may help restore mitochondrial efficiency. 2. Activation of Sirtuins Sirtuins are proteins involved in: Cellular repair Longevity Metabolic regulation Inflammation control NAD+ serves as a critical substrate for sirtuin activity. 3. DNA Repair Support NAD+ is required for enzymes known as PARPs (Poly ADP Ribose Polymerases), which participate in DNA repair processes following cellular injury. 4. Reduction of Oxidative Stress Chronic inflammation often produces excessive reactive oxygen species (ROS). NAD+ may help maintain cellular antioxidant defenses and reduce oxidative injury. Routes of NAD+ Supplementation Intravenous (IV) NAD+ Most commonly marketed in wellness and recovery clinics. Potential advantages: Direct systemic delivery Avoids gastrointestinal absorption issues Allows higher dosing protocols Potential limitations: Cost Time commitment Variable evidence base Oral Precursors Rather than NAD+ itself, many supplements provide precursors such as: Nicotinamide Riboside (NR) Nicotinamide Mononucleotide (NMN) These compounds are converted into NAD+ within the body. What Does the Evidence Show? Current evidence remains preliminary. While preclinical and mechanistic studies are promising, large-scale randomized controlled trials evaluating NAD+ specifically for chronic pain are still limited. Areas under active investigation include: Neuropathic pain Neurodegenerative disorders Chronic fatigue syndromes Recovery optimization Healthy aging Patients should understand that NAD+ therapy remains an emerging treatment rather than a standard evidence-based pain intervention. Safety Considerations Reported side effects may include: Nausea Flushing Chest tightness during rapid infusions Headache Fatigue Lightheadedness Most adverse effects appear infusion-rate dependent and can often be minimized through slower administration protocols. Patients should discuss treatment with a qualified healthcare professional, especially if they have: Cardiovascular disease Active cancer Significant medical comorbidities Clinical Pearls for Pain Physicians ✔ Consider NAD+ as a potential adjunct—not a replacement—for evidence-based pain care. ✔ Continue emphasizing exercise, sleep optimization, nutrition, behavioral health, and appropriate interventional therapies. ✔ Discuss realistic expectations with patients. ✔ Recognize that evidence continues to evolve. ✔ Focus on patient-centered outcomes rather than laboratory markers alone. Key Takeaways NAD+ is essential for cellular energy production and repair. Declining NAD+ levels may contribute to aging, inflammation, and chronic disease. Early evidence suggests possible benefits in inflammation, recovery, fatigue, and nerve health. Robust pain-specific clinical trials remain limited. NAD+ therapy should currently be viewed as an adjunctive and investigational strategy in pain management. Resources for Physicians Pain Medicine Board Preparation Prepare for the ABA Pain Medicine Boards with:

    PainExam Podcast Show Notes NAD+ Supplementation in Pain and Inflammation: Hype, Hope, or Emerging Science? Hosted by: PainExam Podcast Presented by: NRAP Academy (Neuromodulation, Regional Anesthesia & Pain) Host: David Rosenblum, MD Episode Overview In this episode of the PainExam Podcast, we explore the growing interest in NAD+ (Nicotinamide Adenine Dinucleotide) supplementation and its potential role in pain management, inflammation reduction, cellular recovery, and healthy aging. NAD+ is a naturally occurring coenzyme found in every living cell and is essential for energy production, mitochondrial function, DNA repair, and cellular resilience. As NAD+ levels decline with age, chronic stress, inflammation, and disease, researchers have begun investigating whether restoring NAD+ levels may improve outcomes in chronic pain conditions and inflammatory disorders. We review the current science, discuss potential mechanisms of action, and examine how NAD+ therapy is being integrated into regenerative medicine, wellness programs, and pain management practices. What is NAD+? NAD+ is a coenzyme involved in: ✅ Cellular energy production (ATP generation) ✅ Mitochondrial health ✅ DNA repair pathways ✅ Oxidative stress reduction ✅ Neuroprotection ✅ Cellular signaling ✅ Activation of longevity-associated proteins called sirtuins Without adequate NAD+, cells become less efficient at producing energy and managing inflammation. Why Might NAD+ Matter in Chronic Pain? Many chronic pain conditions involve: Mitochondrial dysfunction Oxidative stress Neuroinflammation Peripheral and central sensitization Impaired cellular recovery Researchers hypothesize that optimizing NAD+ levels may help address several of these pathways simultaneously. Potential areas of interest include: Neuropathic Pain NAD+ may support: Nerve repair Axonal recovery Mitochondrial function within neurons Reduction of oxidative injury Inflammatory Pain NAD+ influences inflammatory signaling pathways and may help modulate: Cytokine production Immune cell activity Cellular stress responses Fatigue and Recovery Patients with chronic pain frequently report: Fatigue Brain fog Reduced exercise tolerance Poor recovery Because NAD+ plays a critical role in energy metabolism, some clinicians report improvements in energy and recovery following supplementation. Potential Mechanisms of Action 1. Improved Mitochondrial Function Mitochondria generate ATP, the body's energy currency. Reduced NAD+ levels are associated with: Cellular aging Impaired energy production Increased inflammation Supplementation may help restore mitochondrial efficiency. 2. Activation of Sirtuins Sirtuins are proteins involved in: Cellular repair Longevity Metabolic regulation Inflammation control NAD+ serves as a critical substrate for sirtuin activity. 3. DNA Repair Support NAD+ is required for enzymes known as PARPs (Poly ADP Ribose Polymerases), which participate in DNA repair processes following cellular injury. 4. Reduction of Oxidative Stress Chronic inflammation often produces excessive reactive oxygen species (ROS). NAD+ may help maintain cellular antioxidant defenses and reduce oxidative injury. Routes of NAD+ Supplementation Intravenous (IV) NAD+ Most commonly marketed in wellness and recovery clinics. Potential advantages: Direct systemic delivery Avoids gastrointestinal absorption issues Allows higher dosing protocols Potential limitations: Cost Time commitment Variable evidence base Oral Precursors Rather than NAD+ itself, many supplements provide precursors such as: Nicotinamide Riboside (NR) Nicotinamide Mononucleotide (NMN) These compounds are converted into NAD+ within the body. What Does the Evidence Show? Current evidence remains preliminary. While preclinical and mechanistic studies are promising, large-scale randomized controlled trials evaluating NAD+ specifically for chronic pain are still limited. Areas under active investigation include: Neuropathic pain Neurodegenerative disorders Chronic fatigue syndromes Recovery optimization Healthy aging Patients should understand that NAD+ therapy remains an emerging treatment rather than a standard evidence-based pain intervention. Safety Considerations Reported side effects may include: Nausea Flushing Chest tightness during rapid infusions Headache Fatigue Lightheadedness Most adverse effects appear infusion-rate dependent and can often be minimized through slower administration protocols. Patients should discuss treatment with a qualified healthcare professional, especially if they have: Cardiovascular disease Active cancer Significant medical comorbidities Clinical Pearls for Pain Physicians ✔ Consider NAD+ as a potential adjunct—not a replacement—for evidence-based pain care. ✔ Continue emphasizing exercise, sleep optimization, nutrition, behavioral health, and appropriate interventional therapies. ✔ Discuss realistic expectations with patients. ✔ Recognize that evidence continues to evolve. ✔ Focus on patient-centered outcomes rather than laboratory markers alone. Key Takeaways NAD+ is essential for cellular energy production and repair. Declining NAD+ levels may contribute to aging, inflammation, and chronic disease. Early evidence suggests possible benefits in inflammation, recovery, fatigue, and nerve health. Robust pain-specific clinical trials remain limited. NAD+ therapy should currently be viewed as an adjunctive and investigational strategy in pain management. Resources for Physicians Pain Medicine Board Preparation Prepare for the ABA Pain Medicine Boards with:

Albania, Platner, Trump store owners jailed, HRC TINA, the algae pool, Iran, defeat by snap, Kennedy Center tarp, and THEN Funny, funny memes!https://www.youtube.com/c/FacebookfortheBlindFB4tB► COME to a LIVE recording every Tuesday at 7:30p CST (♫@7:00p)Follow the link below - RSVP by email, then we send a Zoom link about an hour before the show!https://linktr.ee/fb4tb #FB4tB► Like & Subscribe! FB4tB YouTube channel: https://www.youtube.com/c/FacebookfortheBlindFB4tB► Subscribe to the FB4tB podcast HERE: https://bit.ly/3mINXct► Like FB4tB on Facebook: https://www.facebook.com/FB4TB► Follow FB4tB on Twitter: https://twitter.com/FB4tB_WasTaken► Check out another nifty visualizered FB4tB podcast episode here: https://youtu.be/9O9KVHScswUThank you for listening!#Listenable, #FB4tB, #Comedy, #memes, #TuesdayNight, #LIVE, #podcast, filmed before a Live audience

Maria Keena has more about the 72-million-dollar budget cut to the blind pension fund.

Hosts: Ed Jones (Owner of Nutrition World) & Clint Powell A variety of topics all to living a healthy life Presented by: Nutrition World www.nutritionw.com Broadcasting from the Nooga Dentistry Studio www.noogadentistry.com Production of: Whitfield Media Group www.vitalhealthradio.com Title: All about Eggs & Pasture Raised Chickens with Kristy, Deprescribing & “De-Supplementing” with Dr. Curt Dearing [0:00:00] Intro, Nutrition World Updates, and Ed's Bodybuilding Prep Ed announces a new partnership with Azure: Bringing ~100 new holistic food items into Nutrition World. Examples: maple syrup, coconut oil, apple cider vinegar, organic chicken breast, cheeses, farm butters. Ed shares he's preparing for the Chattanooga Fitness Bodybuilding Contest (his 4th year): Being coached by Matt Davis (Train Station gym). Current approach: high protein, ~40% fewer calories, focused fat loss. Matt had him do a high-carb refeed day (~300g carbs vs his usual 50g) which dramatically improved his energy and look. [0:9:11] Protein, Longevity, and Why Ed Focuses on Eggs Ed emphasizes a higher-protein diet, especially for aging, muscle maintenance, and longevity. Core diet elements he advocates: Higher protein Healthy fats Colorful vegetables (in smaller but consistent amounts) Notes many women under-consume protein, which accelerates muscle loss and impacts longevity. Introduces guest Kristy, a long-time friend and staff member who homesteads and raises eggs that Ed eats 12–18 per week. [0:11:04] Homesteading with Kristy: How She Raises Chickens and Protects the Flock Kristy's setup: Around 100 chickens, plus goats, dogs, cats, and a donkey (Bradford). Lives “on the prairie” (rural, wooded property). Uses no chemicals on the property (no weed killers, pest sprays, etc.). She wants chickens to “do chicken things”—roam, peck, eat bugs, move soil—rather than be treated like pets or indoor animals. Predator control: No perimeter fence; previously lost some chickens to a fox attack. Now uses Bradford the donkey and a Great Pyrenees dog for protection: Donkey alerts and deters daytime predators like hawks and owls (stomping and loud calls). Pyrenees patrols at night, primarily deterring coyotes. Roosters herd hens into cover when threats appear. Motivator: Kristy's passion for knowing where her food comes from, and controlling at least part of her family's food system. [0:15:09] Structured Water, and Animal Hydration Kristy filters all animal water with a high-grade system (not just a basic fridge filter): Removes contaminants without completely stripping all minerals (not full RO). Then she “restructures” the water with a swirling device (structure unit): Mimics water flowing over rocks in nature, believed to add “life” and energy back to the water. She and Ed both report feeling better hydration from structured water (less persistent thirst). All of her animals receive this filtered/structured water. [0:17:26] Egg Production, Breeds, and Why Yolk Color Matters Kristy keeps multiple chicken breeds: Shell color = breed, not nutrition (white, brown, cream, etc., are just different breeds). Example: White Leghorn → white eggs, Rhode Island Red → darker brown eggs. Key nutritional indicator: yolk color She aims for deep orange yolks. Pale yellow yolks signal lower nutrient density, especially protein and nutrient intake from the chickens' diet. Production basics: Most hens lay about 5–6 eggs per week, especially in their first 3 years. Ed and Clint estimate she's getting hundreds of eggs per week in total. Kristy's flock policy: She has a “no-kill” policy for older hens, keeping them for tick and bug control and the social flock structure. Acknowledges some people cull flocks after 2–3 years, but she tends to keep productive, healthy hens past 4 years. [0:19:37] Industrial Eggs vs. Pasture-Raised: Animal Welfare and Nutrition Ed contrasts Kristy's setup with CAFO operations (Concentrated Animal Feeding Operations): Chickens crowded in small cages, poor conditions, bad feed. Notes such operations often use antibiotics—partly for disease, but also because they fatten animals. Kristy's holistic management: No antibiotics; uses natural anti-parasite and immune support: Pumpkin seeds for worms Homegrown herbs like oregano and rosemary She builds a strong “terrain” (internal environment) in the animals so they resist disease better. Discussion that what chickens eat (seed oils, moldy grains, etc. in industrial systems) ultimately affects the nutritional quality of the eggs humans eat. Nutritional highlights of eggs: Choline in yolks (brain and cognitive health). A “perfect protein” with high biological value and broad micronutrients. Eggs historically rank at the top for turning dietary protein into muscle due to a complete amino acid profile. Cholesterol discussion: Ed challenges the blanket fear of cholesterol: Cholesterol supports hormone production and brain function. Notes that the real risk markers are advanced lipoproteins like ApoB and Lp(a), not total cholesterol alone. Personal example: Ed eats 12–18 eggs per week. & his cholesterol is extremely low by clinical standards. Conclusion: Quality eggs are encouraged, especially from pasture-based systems like Kristy's, or higher-quality options in stores. [0:23:15] “Organic” vs. “Pasture-Raised” and Misleading Egg Labels “Organic eggs”: fed organic feed but may still be confined indoors with no outdoor access. “Pasture-raised”: hens are outdoors on pasture, doing natural chicken behaviors; often superior in welfare and nutrition. Both agree: If forced to choose, pasture-raised is preferable to organic-only. They call out labels bragging about “vegetarian-fed” hens as misleading: Chickens are not natural vegetarians; they're omnivores that eat bugs. Forcing a vegetarian diet moves them away from their natural food and may reduce egg quality. Kristy shares a quirky but natural behavior: Chickens love scrambled eggs as a treat. She feeds them scrambled eggs and crushed shells. Rationale: Eggshells are rich in calcium, which hens need to build strong new shells. She simply cracks and throws shells; no elaborate processing.. [0:27:25] Refrigeration vs. Room-Temperature Egg Storage Kristy's explanation: Freshly laid eggs have a “bloom” or natural protective coating that makes them shelf-stable if not washed. Unwashed farm eggs can sit at room temperature for ~6 weeks or more. Store-bought eggs are washed and must be refrigerated, because washing removes that protective coating. You cannot safely leave standard grocery-store eggs on the counter. Ed highlights this as another example of nature's built-in protective design. [0:32:28] Deprescribing and “De-Supplementing” with Dr. Curt Dearing Ed reintroduces Dr. Curt Dearing to expand on a prior show about deprescribing (reducing excessive medications). Common scenario Curt sees: People on many prescription meds plus a large number of supplements, overwhelmed and confused. They want to simplify, optimize, and know what really matters. Curt's consult approach: Review all meds and all supplements, then: Remove what isn't necessary. Emphasize foundational lifestyle and core supplements. They warn about a false sense of security: Some people think “I'm taking a pill, so I don't have to change my habits.” This applies to both pharmaceuticals and nutraceuticals. [0:36:00] The Core Four, Lifestyle First, and Limits of Medication-Only Approaches Ed references his “Core Four” foundational supplements (detailed in a free ebook on The Holistic Navigator): Designed as tier 1 essentials vs. lower-tier “nice-to-have” supplements. Curt's stance: Diet and exercise are the primary pillars. Supplements should support, not replace, healthy habits. Example: People on metformin or berberine may keep eating poorly yet feel “covered” because their blood sugar numbers look better. This is managing symptoms, not addressing root causes. [37:15] “Beyond Cholesterol” and Advanced Heart Risk Testing Curt mentions his upcoming ebook “Beyond Cholesterol” (targeting Amazon release): Argues standard lipid panels (total cholesterol, LDL, HDL) are not enough. Advocates for advanced tests like ApoB, Lp(a), and coronary calcium scores. Example case: A patient with LDL of 212 on atorvastatin. Curt notes that LDL alone can be “dangerous or harmless” depending on the underlying particle types and inflammation. Coronary Calcium Score: Patient's score is 0, which is reassuring but not a free pass. Calcium score detects calcified plaque, not soft plaque, and doesn't capture inflammation. Curt emphasizes HS-CRP (high-sensitivity C-reactive protein) as a marker of systemic inflammation, which drives soft plaque formation. [0:40:22] Medications in the Case Study: Statin, Nexium, Amlodipine, Zoloft Curt walks through a specific patient on multiple meds: Atorvastatin (statin) Curt questions its necessity given: Calcium score of 0 Lipid values that don't look catastrophic Recommends advanced lipid testing and provides patients with evidence-based reasons to discuss with their provider if they want to stop. Nexium (PPI) Discusses risks of long-term proton pump inhibitor use: Impaired absorption of magnesium, calcium, micronutrients Possible cognitive, kidney, and bone issues. Insists on a taper, not cold turkey, due to rebound reflux. Amlodipine (blood pressure med) Often can be tapered fairly quickly, especially when: Lifestyle changes are implemented (diet, exercise). Magnesium intake is optimized (many people take too little magnesium). Curt's view: conventional medicine often drives blood pressure too low in older adults; some elevation is physiologically adaptive. Zoloft (SSRI) Must be tapered, like most psychiatric meds, to avoid withdrawal and symptom flare. [0:46:10] Magnesium, Omega-3s, and Simplifying the Supplement Stack Curt reviews the patient's supplement list and simplifies: Multivitamin: Advocates a high-quality multi (not basic synthetics like Centrum). Prefers one that already includes CoQ10 (e.g., 100 mg), so separate CoQ10 can be discontinued. Vitamin D: Should be taken with vitamin K to direct calcium into bone and away from arteries and organs. Omega-3s: Many people take half the necessary dose. Recommends triglyceride-form omega-3s like DHA Extra (~960 mg DHA) for inflammation and blood pressure. Magnesium: Suggests glycinate or taurate forms for better absorption and blood pressure benefits. Probiotics: Curt suggests taking breaks (e.g., a month off) and rotating brands/strains, including spore-based types. Seasonal products: The patient takes quercetin + stinging nettle for allergies. Curt recommends seasonal use only for seasonal allergies, saving money and reducing pill fatigue. For lipids and blood sugar, Curt favors BerberCol (berberine + bergamot) to: Improve numbers (to satisfy doctors). More meaningfully affect ApoB and related risk markers. Weight & energy: Patient had been using weight-loss products. Curt shifts focus to fixing sleep and overall lifestyle rather than stacking more “fat burners.” Saffron: He distinguishes between saffron extracts for mood vs. saffron for weight management—formulation details matter. [0:54:57] Closing: Funding for Alternative Health and Supplement Tax Benefits Ed shares policy/legislative updates: Alternative health funding preserved in the federal budget. Initial fear that support would be cut; instead, it was kept in the proposed budget. The Dietary Supplement Access Act proposal: Would classify dietary supplements as a qualified medical expense in the IRS code. Allow individuals to claim up to $500/year (and $250 for married filing separately) for supplements. Could apply to common products like multivitamins, vitamin D, etc. if/when finalized.  The post Radio Show / Podcast – June 14, 2026 first appeared on Vital Health Radio.

Woman files lawsuit that claims she was injured by McDonald's Sausage McMuffin 'wholly unfit of human sonsumption', Canadian man facing charges for kayaking while impaired...then there's the part about the kayak being stolen and him using a snow shovel to paddle...Three workers arrested at bungee jump after failing to attach proper harness to 21-year-old who plunged to her deathSee omnystudio.com/listener for privacy information.

Woman files lawsuit that claims she was injured by McDonald's Sausage McMuffin 'wholly unfit of human sonsumption', Canadian man facing charges for kayaking while impaired...then there's the part about the kayak being stolen and him using a snow shovel to paddle...Three workers arrested at bungee jump after failing to attach proper harness to 21-year-old who plunged to her death

Glasgow Tandem club members Anne Fraser and Dianne Lusman have spent many hours and miles together. They came on Good Company in April 2025 to about talk communication, syncing up when cycling and recovering from a crash.Listen to Good Company, RNIB Connect Radio's relationship show, on the first Tuesday of each month at 7 pm and 8pm on the first sunday of each month.Image shows the RNIB Connect Radio logo. On a white and black background ‘RNIB' written in bold black capital letters and underline with a bold pink line. Underneath the line: ‘Connect Radio' is written in black in a smaller font. 

Donny skipped Don Jr.s wedding, napped, Shaprio lost 90% of audience and reduced to playing Fortnite, your Cybertruck is NOT A BOAT! Then, funny memes!1:09 News17:00 News End17:17 QM Rd 128:22 ES End RD128:33 QM Rd2 = the Filler Roundhttps://www.youtube.com/c/FacebookfortheBlindFB4tB► COME to a LIVE recording every Tuesday at 7:30p CST (♫@7:00p)Follow the link below - RSVP by email, then we send a Zoom link about an hour before the show!https://linktr.ee/fb4tb #FB4tB► Like & Subscribe! FB4tB YouTube channel: https://www.youtube.com/c/FacebookfortheBlindFB4tB► Subscribe to the FB4tB podcast HERE: https://bit.ly/3mINXct► Like FB4tB on Facebook: https://www.facebook.com/FB4TB► Follow FB4tB on Twitter: https://twitter.com/FB4tB_WasTaken► Check out another nifty visualizered FB4tB podcast episode here: https://youtu.be/9O9KVHScswUThank you for listening!#Listenable, #FB4tB, #Comedy, #memes, #TuesdayNight, #LIVE, #podcast, filmed before a Live audience

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Traffic deaths declined overall in 2025, but several Mountain West states saw increases. The new initiative focuses on risky driving behaviors.

Joseph Roethel, director, AM Best, discusses two Best's Special Reports that found no catastrophe-driven P/C impairments following three years of elevated storm losses, while recent health impairments include a number of troubled affiliates.

I've seen police make the argument at the side of the road that this could happen - and it very well may have on this occasion. https://www.lehtoslaw.com

If you're dealing with unexplained digestive issues, chronic stress, low libido, or irregular heart rate, your vagus nerve may be involved. In this video, I've compiled the most common signs of vagus nerve dysfunction and how it impacts everything from inflammation to brain function. You'll also learn practical ways to support and stimulate your vagus nerve naturally through lifestyle strategies, targeted nutrition, and gut-focused therapies.  

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Pregnancy in Women With Impaired Left Ventricular Function: Data From ROPAC.

We discuss the diagnosis and treatment of one of EM's paradoxes: High-Output Heart Failure. Hosts: Nicolas Gonzalez, MD Brian Gilberti, MD https://media.blubrry.com/coreem/content.blubrry.com/coreem/HOHF.mp3 Download Leave a Comment Tags: Cardiology Show Notes Core EM Modular CME Course Maximize your commute with the new Core EM Modular CME Course, featuring the most essential content distilled from our top-rated podcast episodes. This course offers 12 audio-based modules packed with pearls! Information and link below.  Course Highlights: Credit: 12.5 AMA PRA Category 1 Credits™ Curriculum: Comprehensive coverage of Core Emergency Medicine,  with 12 modules spanning from Critical Care to Pediatrics. Cost: Free for NYU Learners $250 for Non-NYU Learners Click Here to Register and Begin Module 1 1. Core Definition & Hemodynamic Profile Clinical Paradox: Congestive symptoms (pulmonary edema, JVD, peripheral edema) in the setting of a hyperdynamic, supranormal cardiac function. Hemodynamic Criteria: Cardiac Index (CI): >4.0 L/min/m2. Cardiac Output (CO): >8 L/min. Systemic Vascular Resistance (SVR): Pathologically low (vasodilated or shunted state). The “Warm” Phenotype: Unlike standard HFrEF/HFpEF (often “Cold and Wet”), HOHF presents as “Warm and Wet” due to low SVR and bounding pulses. 2. Pathophysiology: The Hemodynamic Paradox Primary Insult: Decreased SVR (either via peripheral vasodilation or arteriovenous shunting). Effective Arterial Blood Volume: Paradoxically low despite high total CO. Neurohormonal Cascade: Activation of Renin-Angiotensin-Aldosterone System (RAAS). Increased Sympathetic Nervous System tone. Increased Antidiuretic Hormone (ADH) secretion. Resultant State: Avid renal salt and water retention leading to massive plasma volume expansion. Cardiac Response: Chronic volume overload → eccentric remodeling → chamber dilation → eventual secondary myocardial failure/dilated cardiomyopathy. 3. Differential Diagnosis: Etiological “Buckets” Category A: Increased Metabolic Demand (Systemic) Hyperthyroidism/Thyrotoxicosis: Direct T3 effects: increased chronotropy/inotropy. Indirect effects: metabolic byproduct accumulation causing peripheral vasodilation. Myeloproliferative Disorders: High cell turnover and increased oxygen consumption drive compensatory CO increase. Sepsis (Hyperdynamic Phase): Cytokine-mediated global vasodilation. Note: Often transient; may transition to sepsis-induced myocardial depression. Category B: Peripheral Vascular Effects (Shunting/Vasodilation) Arteriovenous Fistulas (AVF) / Malformations (AVM): Most Common Cause: Iatrogenic AVF for Hemodialysis (ESRD population). Bypasses high-resistance capillary beds, dumping arterial blood directly into venous circulation. Chronic Liver Disease (Cirrhosis): Formation of “spider angiomata” and internal AV shunts. Impaired clearance of endogenous vasodilators (e.g., Nitric Oxide). Thiamine Deficiency (Wet Beriberi): Accumulation of pyruvate/lactate → systemic vasodilation. Histopathology: Vacuolation, myofiber hypertrophy, and interstitial edema. Chronic Lung Disease: Hypoxia/Hypercapnia-driven systemic vasodilation. Concomitant pulmonary HTN (RV remodeling) but preserved/high LV output. Others: Paget's disease of bone (extensive micro-shunting), Carcinoid syndrome, Mitochondrial diseases, Acromegaly, Erythroderma. 4. Special Focus: Hemodialysis Access-Induced HOHF Physiologic Phases of AVF Creation: Acute Phase: Immediate ↓ SVR. ↑ Stroke volume and Heart Rate (SNS-mediated). Endothelial shear stress → Nitric Oxide release → further arterial dilation. Subacute Phase (Days to 2 Weeks): RAAS-driven volume expansion. ↑ Right Atrial, Pulmonary Artery, and LV End-Diastolic Pressures (LVEDP). Natriuretic peptide surge (BNP/ANP) peaks around Day 10. Chronic Phase (Weeks to Months): Adaptive hypertrophy. Decompensation occurs when dilation exceeds contractility limits. 5. Point-of-Care Physical Exam & Maneuvers Nicoladoni-Branham Sign (Pathognomonic for Shunt-driven HOHF): Maneuver: Manually compress the AVF (or inflate cuff to >50 mmHg above SBP) for 30 seconds. Positive Result: Reflexive bradycardia or a transient rise in systemic BP. Significance: Confirms the shunt is a major contributor to the cardiac workload. Peripheral Pulse Assessment: Water Hammer Pulses: Rapid upstroke and collapse. Quincke's Pulse: Visible capillary pulsations in the nail beds. Traube's Sign: “Pistol-shot” sounds auscultated over the femoral arteries. Volume Status: Rales, S3 gallop, peripheral edema (standard HF signs). 6. Diagnostic Workup (Technical Targets) POCUS / Echocardiography: Left Ventricle: Hyperdynamic function; EF typically >60%. Left Atrium: Significant dilation (Left Atrial Volume Index >34 mL/m2; Case study noted 72 mL/m2). IVC: Plethoric with minimal respiratory variation. Doppler: High flow velocities across the AV access if applicable. Laboratory Evaluation: BNP/NT-proBNP: Often markedly elevated (e.g., >70,000 in severe cases), though mean values in literature hover around 700–800 pg/mL. Hematology: CBC to evaluate for severe anemia (trigger for HOHF if Hgb7–8 g/dL to reduce demand. Beriberi: High-dose IV Thiamine (100–500 mg). Thyrotoxicosis: Beta-blockers (Propranolol) + Antithyroid meds (PTU/Methimazole). Phase 3: Surgical/Interventional Salvage (Refractory AVF Cases) Closure of Accessory Sites: If multiple fistulas exist, close the non-dominant/unused sites. Flow Reduction (Banding): Surgical narrowing of the fistula to target flow

This week on Mel & Floyd: Smarty Pants minds the store [with help from Saga and Luther] while Mel is off in search of the perfect beer; Treason for a reason; Hatin' on billionaires; Laundry fire on the USS Gerald R. Ford; Nazis are all about the merch; All about flags; The politics of vector graphics; And other random topics; Notice something missing?  For the complete Mel and Floyd Experience, buy the CD “The Very Best of James Brown” and play it on your Hi-Fi while listening to this podcast!  Or listen live at 89.9 FM or wortfm.org/listen-live/ every Friday from 1 to 2 PM Central Time. Photo courtesy Hal Gatewood on Unsplash Did you enjoy this story? Your funding makes great, local journalism like this possible. Donate hereThe post Tablets for the Irony Impaired appeared first on WORT-FM 89.9.

This episode of RAPM Focus challenges physicians to think differently about pain after cesarean delivery by showcasing a new approach for patient care after cesarean delivery. RAPM Executive Editor Eric Schwenk, MD, explores the SPACE-postpartum model with Sarah Ciechanowicz, BMBCh, FRCA, following the October 2025 publication of her brief technical report, “SPACE-Postpartum: a multidomain biopsychosocial framework for predicting chronic pain and impaired recovery after cesarean delivery – proof-of-concept report.” The SPACE-postpartum model is essentially a multidomain symptom system for understanding recovery after cesarean delivery. This biopsychosocial framework brings together five interconnected symptom areas—sleep, pain, affect, cognition, and energy—for early risk assessment after surgery, offering a comprehensive approach to the entire recovery process after cesarean delivery. Early recovery is not just about pain scores, but about a pattern of symptoms that tend to cluster and shape a patients' long-term trajectory. By assessing that pattern early on, we could potentially identify a modifiable risk profile for chronic pain and impaired recovery.  Dr. Sarah Ciechanowicz (“Chye-kha-no-vich”) is a consultant anesthetist at University College London Hospitals, researcher at Imperial College London, and former visiting fellow in obstetric anesthesia research at Stanford University. Her work focuses on improving postpartum recovery and pain prediction after caesarean delivery. She developed the SPACE-Postpartum framework—a multidomain biopsychosocial model designed to identify women at risk of chronic pain and inform intervention in the early postpartum period. *The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice, and it is not intended to function as a substitute for a healthcare practitioner's judgement, patient care, or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others. Podcast and music produced by Dan Langa. Find us on X @RAPMOnline, LinkedIn @Regional Anesthesia & Pain Medicine, Facebook @Regional Anesthesia & Pain Medicine, and Instagram @RAPM_Online.

In this encore episode, we detail connections between H. pylori and hypochlorhydria, while highlighting possible downstream effects on nutrient absorption. We examine how reduced gastric acidity can impair the liberation and assimilation of certain micronutrients, including iron, calcium, vitamin B12, and more; and we further discuss the impact of low stomach acid upon downstream digestive enzyme activation and gut microbial balance. Topics:1. Hypochlorhydria - Low stomach acid.2. H. pylori 3. Gastric Anatomy & Layers- The stomach: hollow, muscular organ for mechanical and chemical digestion.- Regions: Cardia, fundus, body, and pylorus.- Layers: Mucosa, Submucosa, Muscularis externa, Serosa4. Mucosal Layer - Surface mucous cells secrete a thick bicarbonate-rich, protective mucus.- Gastric pits lead to gastric glands, which contain specialized secretory cells.5. Specialized Gastric Cells- Parietal Cells: Secrete hydrochloric acid (HCl) and intrinsic factor (IF).- Chief Cells: Secrete pepsinogen (converted to pepsin by HCl) and gastric lipase.- Role of HCl: Activates pepsin, denatures proteins, and contributes to nutrient absorption.- Intrinsic factor and vitamin B12 absorption.6. Vitamin B12 Absorption- Essential for DNA synthesis, RBC formation, neurological function.- Released from food proteins by gastric acid and pepsin.- Impaired absorption.7. Role of Gastric Acid in Broader Micronutrient Absorption- Absorption of minerals.- Soluble, ionized state.- Iron: HCl aids in preventing insoluble precipitates and supports iron absorption.8. Protective Role of Gastric Acid- Acts as a line of defense against ingested pathogens.- Maintains low microbial diversity in the stomach.- Low HCl and Small Intestinal Bacterial Overgrowth.9. Symptoms of Low Stomach Acid- Bloating, early satiety, excessive belching.- Undigested food in stool, chronic constipation.- May reflect impaired enzymatic activation and digestive insufficiency.10. Conclusion- Multifactorial causes and downstream effects.- Optimal range, neither high nor low.Thank you to our episode sponsor: 1. "Longevity" with Protein, Probiotics, Bovine Colostrum, Collagen, and More. Use code CHLOE for 25% off.*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.Thanks for tuning in!Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

Connecticut has a real problem with impaired driving. A new report was released by The Connecticut Forensic Lab and shows many drivers tested for drinking and driving earlier this year, also had drugs detected in those tests. We spoke with Dr. Jessica Gleba, Director of forensic laboratory operations with the Department of Emergency Services and Public Protection's Division of Scientific Services, about the latest statistics.

Incest and inbreeding? It's a taboo for humans, so why is it ok for dogs? Your cute smushed-faced dog is suffering. And AKC is not OK. What's PETA doing about it? Plenty. Jakob Shaw tells Emil the problems with BIBs, that's stands for breathing impaired breeds. Time to take a stand against torture breeding. For more go to PETA.org.    

Too busy to read the Lens? Listen to our weekly summary here! In this week's episode we discuss…Impaired fasting glucose and diabetes are linked to significantly increased risk of third, fourth, and sixth cranial-nerve palsies.Experts created standardized grading scales to improve detection and management of ocular toxicities from emerging cancer therapies.ChatGPT o1 Pro performed comparably to glaucoma specialists in diagnosing glaucoma from visual field and OCT-RNFL data.

A 25,000-pound semi veering across the highway wasn't an isolated scare, it's part of a nationwide epidemic. Impaired driving kills 12,000 Americans a year, costs billions, and continues to be dismissed as a "mistake" instead of the lethal choice it is.Stop it NOW!  @MADDNational This episode is brought to you by BIOptimizers | Magnesium Breakthrough: Visit: https://bioptimizers.com/drphil Promo Code: DrPhil for 15% off and 25% off during black Friday. Stronger, longer, better life.    

A Computational Account of Borderline Personality Disorder: Impaired Predictive Learning About Self and Others Through Bodily SimulationIn this episode, Dr. Jud Brewer, Dr. Sarah Fineberg, and Dr. Philip Corlett explore an innovative computational psychiatry model of borderline personality disorder (BPD). Social dysfunction is a core feature of BPD, and this study proposes that individuals with BPD struggle with predictive learning about self and others due to deficits in embodied simulation—using one's own bodily experiences to infer the mental states of others. The discussion covers how computational models can help explain emotional dysregulation, attachment disruptions, and the instability of interpersonal relationships in BPD, offering new insights into treatment approaches. Tune in to discover how neuroscience, machine learning, and psychiatry intersect to deepen our understanding of personality disorders.Full Reference:Fineberg, S. K., Steinfeld, M., Brewer, J. A., & Corlett, P. R. (2014). A computational account of borderline personality disorder: Impaired predictive learning about self and others through bodily simulation. Frontiers in Psychiatry, 5, 111. https://doi.org/10.3389/fpsyt.2014.00111Let's connect on Instagram

From its nearly three-hour runtime to its deployment of some of the most deranged CGI you've ever seen committed to screen, Radu Jude's DRACULA often feels like an extended act of trolling, but is it art? The answer to that question is inextricable from the film's presentation of AI-derived art as grotesque, inhuman, and unsatisfying, and it makes DRACULA arguably more entertaining to discuss than it is to watch. So after attempting to pull some meaning out of what the critic in 8 1/2 might describe as DRACULA's “series of gratuitous episodes,” we move into Connections for a study in contrasts between Fellini's portrait of an artist struggling to make a personal work, and Jude's evisceration of a charlatan trying to outsource artistry to a machine. Then in Your Next Picture Show, we discuss another film we considered as a DRACULA pairing that may not be quite as celebrated as 8 1/2, but we nonetheless recommend as another depiction of a filmmaker in creative crisis: Christopher Guest's debut feature, THE BIG PICTURE. Please share your thoughts about 8 1/2, DRACULA, or anything else in the world of film, by sending an email or voice memo to comments@nextpictureshow.net, or leaving a short voicemail at (773) 234-9730. Next episode: A celebration of Peter Bogdanovich's THE LAST PICTURE SHOW, and 500 episodes of a niche film podcast named after it. Intro: 00:00:00-00:01:57 Dracula discussion: 00:01:57 - 00:27:20 Dracula/8 1/2 Connections: 00:27:20 - 00: 48:11 Your Next Picture Show and goodbyes: 00:48:11-end Learn more about your ad choices. Visit megaphone.fm/adchoices

Due to Alzheimer's research focusing on a symptom of it (amyloid plaques), rather than its actual cause, Alzheimer's has remained "incurable" for decades Rather than being a single disease, Alzheimer's has multiple different subtypes (e.g., those due to insulin resistance, nutritional deficiencies, inflammation, infections, or concussions), each of which requires a different treatment Impaired blood circulation to the brain and lymphatic drainage from the brain are often the primary trigger that initiates the degenerative process seen in Alzheimer's disease. Factors which impair this circulation (e.g., poor sleep) hence roughly double the risk of dementia, while treatments which improve this circulation frequently produce remarkable improvements for cognitive decline and dementia DMSO is an effective treatment for brain injuries like strokes, and well-suited to address many of the root causes of dementia and reverse the degenerative state that dying neurons get trapped in. Because of this, there are many reports of it reversing dementia and clinical trials in both humans and animals corroborating these improvements This article will review the actual causes of dementias like Alzheimer's and the forgotten therapies many have successfully used to cure them

Radu Jude's DRACULA is, technically speaking, yet another movie about one of the most depicted antagonists in all of cinema, but in actuality it's about a different beast that has fascinated filmmakers for nearly as long: filmmaking. Within the grand tradition of “movies about moviemaking,” DRACULA's surreal humor, combined with its focus on a struggling filmmaker fantasizing about the film he might make, gave us an excuse to revisit an all-time classic of the form, Federico Fellini's 8 1/2. So this week we search for meaning within 8 1/2's reveries of a blocked creative mind, interrogate the “semi” part of Fellini's semi-autobiographical approach, and touch on some of the other films that exist in the shadow of this one. Then in Feedback, our recent pairing of RUNNING ON EMPTY and ONE BATTLE AFTER ANOTHER inspires a supplementary-listening suggestion for the former, and a head canon explanation for one of our questions about the latter.Please share your thoughts about 8 1/2, DRACULA, or anything else in the world of film, by sending an email or voice memo to comments@nextpictureshow.net, or leaving a short voicemail at (773) 234-9730.Intro: 00:00:00-00:05:128 1/2 Keynote: 00:05:12-00:11:398 1/2 Discussion: 00:11:39-48:26Feedback/outro: 00:48:26-end Learn more about your ad choices. Visit megaphone.fm/adchoices

This week we discuss the dangers of impaired driving. Impaired driving poses significant dangers, leading to thousands of fatalities and injuries each year due to reduced coordination, judgment, and reaction times. Definition and Causes Impaired driving occurs when an individual operates a vehicle while under the influence of substances such as alcohol, marijuana, prescription drugs, or illicit drugs. These substances can severely impair essential driving skills, including visual function, mental judgment, and motor skills. Statistics Alcohol-Related Fatalities: In the United States, approximately 29 people die daily in crashes involving alcohol-impaired drivers, accounting for about 30% of all traffic-related deaths. Drug Impairment: A significant number of drivers involved in serious crashes test positive for drugs. In a study, 51.6% of drivers involved in serious injury and fatal crashes had at least one drug in their system prior to the incident. Effects of Impairment Alcohol: Even a single drink can impair driving abilities, leading to decreased reaction times and poor decision-making. The legal blood alcohol concentration (BAC) limit is typically set at 0.08%, but impairment can begin at lower levels. Drugs: Both legal and illegal drugs can impair driving. For instance, marijuana can affect coordination and judgment, while stimulants like cocaine can lead to aggressive driving behaviors. Medications: Some prescription and over-the-counter medications can cause drowsiness and dizziness, further increasing the risk of accidents. Preventive Measures Education and Awareness: Public campaigns aimed at educating drivers about the dangers of impaired driving are crucial. Understanding the effects of substances on driving can help reduce incidents. Designated Drivers: Encouraging the use of designated drivers, taxis, or rideshare services can significantly reduce the risk of impaired driving. Legal Enforcement: Strict enforcement of DUI laws and sobriety checkpoints can deter impaired driving behaviors. Conclusion Impaired driving is a serious public safety issue that leads to numerous preventable deaths and injuries each year. By understanding the dangers and implementing effective preventive measures, we can work towards reducing the incidence of impaired driving and ensuring safer roads for everyone.

I bet you thought it was ENTIRELY about the carbs you were eating that were responsible for your weight gain, or slide into mild cognitive impairment.Well, you're not entirely wrong, however, having lots of carbs puts an increased demand on your ability use and produce choline. High carbs are one of the reasons for the choline deficiency, the other reason is that some people 25 - 40+ percent are limited in their abilty to use and manufacture choline (from Bile, to acetyl choline a vital neurotransmitter, and more). Having high carbs (carbs in general), not consuming enough choline (egg yolks and liver) and having specific SNPs (single nuclear polymorphisms) that predispose you to not being able to use choline well, or at all, puts you unequivocally at risk for cognitive impairment, dementia, and NAFD, if not obesity as well.The GOOD NEW is that it is correctable without medications through dietary changes.I kid you not.

Before an evaluation, Arial is reviewing the patient's MRI report that describes sequestration at the L4 – L5 level. The intake form reveals sensory changes along the lateral calf, and dorsum of the foot. Which clinical finding is the most consistent with the medical record? A) Impaired heel walking B) Gastrocnemius and soleus atrophy C) Extensor hallicus longus weakness D) Saddle paraesthesiaTEXT OUR TEAM:(727) 732-4573

Amy and T.J. go over the expletive riddled, headline making, 3 hour interview with Hunter Biden. Not only does Hunter drop a bombshell that his father was on Ambien leading up to his devastating debate with Trump, but he also goes after actor George Clooney, accusing him of stepping on and undermining his father, telling him to “F*#% Off.”See omnystudio.com/listener for privacy information.

Amy and T.J. go over the expletive riddled, headline making, 3 hour interview with Hunter Biden. Not only does Hunter drop a bombshell that his father was on Ambien leading up to his devastating debate with Trump, but he also goes after actor George Clooney, accusing him of stepping on and undermining his father, telling him to “F*#% Off.”See omnystudio.com/listener for privacy information.

Amy and T.J. go over the expletive riddled, headline making, 3 hour interview with Hunter Biden. Not only does Hunter drop a bombshell that his father was on Ambien leading up to his devastating debate with Trump, but he also goes after actor George Clooney, accusing him of stepping on and undermining his father, telling him to “F*#% Off.”See omnystudio.com/listener for privacy information.