Podcasts about ieeg

What is the Human Brain Project and how might it advance epilepsy research? Dr. Maryam Nouri speaks with Dr. Philippe Ryvlin about the project in terms of the Human Intracerebral EEG Platform and how compiling these unique data from around the world could lead to new breakthroughs and understanding of epilepsy.The Human Intracerebral EEG Platform is an open-source platform designed for collecting, managing, analyzing, and sharing iEEG data at an international level. Its primary mission is to promote the development of large-scale iEEG research projects by facilitating international collaborations in the field.Links:Human Brain ProjectHuman Intracerebral EEG PlatformThe Virtual Brain Registration is now open for the 15th European Epilepsy Congress, held September 7th through 11th in Rome, Italy. Join your colleagues for five days of teaching courses, symposia, platform sessions, career development sessions, and more! To receive a discount on registration fees, register by May 10. Visit the ILAE website for more information, or register directly at bit.ly/ilaerome. That's

La incorporación de ChatGPT en la gestión de proyectos ofrece un valor inmenso, no solo en términos de eficiencia y precisión, sino también en la capacidad de adaptarse y aprender constantemente. Al actuar como un asistente virtual, ChatGPT reduce la carga de trabajo de los gestores de proyectos y permite a los equipos centrarse en tareas más críticas y creativas. A medida que la tecnología continúa evolucionando, es probable que veamos aún más aplicaciones y funcionalidades de ChatGPT en el ámbito de la gestión de proyectos, llevando la disciplina a nuevos horizontes. Noticias: Según AIM, el popular chatbot ChatGPT le cuesta a OpenAI ~700.000 dólares al día y la quiebra podría llegar en 2024. 3.500 participantes compiten actualmente por descubrir vulnerabilidades en los principales modelos de chatbot de IA en la convención de hackers DefCon de Las Vegas. Microsoft acaba de lanzar una versión de código abierto de ChatGPT adaptada a casos de uso empresarial. Bautizada como "Azure ChatGPT", promete más control y privacidad en comparación con el modelo público. Amazon recurre a la IA generativa para crear prácticos elementos destacados que sintetizan los puntos clave de las opiniones de los clientes y ayudan a los compradores a evaluar rápidamente la opinión sobre un producto. Una paciente británica que sufrió un ictus vuelve a caminar de forma independiente gracias a unos "pantalones inteligentes" controlados por inteligencia artificial. Google ha desplegado nuevas capacidades de IA para Search Generative Experience (SGE) con el fin de mejorar el aprendizaje y ayudar a los usuarios a digerir información compleja. Neurocientíficos de la Universidad de Berkeley acaban de reconstruir "Another Brick in the Wall" de Pink Floyd utilizando grabaciones cerebrales iEEG e IA. Dos antiguos investigadores de IA de Google han lanzado Sakana AI, una empresa emergente de Tokio que combina varios modelos de IA más pequeños. Kristen Garcia Dumont, ex directora ejecutiva de Machine Zone, ha fundado una nueva aplicación de redes sociales llamada BeFake para redefinir las redes sociales. Herramientas WorkbookPDF- Cuadernos gramaticales personalizados de AI (Enlace) MindPal- Un segundo cerebro construido con IA (Enlace) MeMemes- Conviértete en un meme con la IA (enlace) Jasper- Un asistente de redacción AI para generar cualquier tipo de copia de marketing (Enlace) Browse- Entrene un robot en 2 minutos para extraer datos de cualquier sitio web (Enlace) Sheet AI- Pon IA en tus hojas de cálculo de Google (Enlace) Clearmind- Terapia de IA personalizada para todos (Enlace) PDFPals- chatea al instante con cualquier PDF en Mac (Enlace) Bardeen- Herramienta de automatización sin código para mejorar la productividad del flujo de trabajo (Enlace) Dreamdecoder- Comprende el significado de tus sueños gracias a la IA (enlace) Superdash- Cree rápidamente formularios basados en IA (Enlace) Songburst- Genera música AI desde tu móvil (enlace) MealPractice- Planificación de comidas sin esfuerzo con recetas generadas por inteligencia artificial (Enlace) Aizzy- Muévase más rápido con los asistentes de IA (Enlace) SayData- Crear análisis orientados al cliente (Enlace) Human Generator- Crear personas en tiempo real con IA (Enlace) TweetHunter- Herramienta de crecimiento de Twitter todo en uno para crear contenido utilizando IA, crear una audiencia y programar publicaciones. (Enlace) Plan de Asesoria Personal Canal de Youtube Déjame un mensaje de voz

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.04.05.535577v1?rss=1 Authors: Peterson, V., Vissani, M., Luo, S., Rabbani, Q., Crone, N. E., Bush, A., Richardson, M. Abstract: Neurosurgical procedures, in which electrodes can be placed in the brain of awake patients, offer remarkable opportunities to discover the neurophysiology underlying human speech. The relative scarcity of these opportunities and the altruism of participating patients obligates us to apply the highest possible rigor to signal interpretation. Intracranial electroencephalography (iEEG) signals recorded during overt speech can present an acoustic-induced vibration artifact that tracks the fundamental frequency (F0) of the participant's voice, encompassing high-gamma frequencies that are used for neural activation during speech production and perception. To advance our understanding of the neural control of speech production and develop reliable speech models, we developed a spatial filtering approach to identify and remove acoustic-induced artifactual components of the recorded signal. We show that traditional reference schemes may jeopardize signal quality, but our data-driven method can denoise the recording while preserving signals from the underlying neural activity. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.12.01.518775v1?rss=1 Authors: Wu, T. Q., Kaboodvand, N., Veit, M., McGinn, R. J., Davey, Z., Datta, A., Graber, K. D., Meador, K. J., Fisher, R., Buch, V., Parvizi, J. Abstract: Neuromodulation of the anterior nuclei of the thalamus (ANT) has shown to be efficacious in patients with refractory focal epilepsy, but it is not uniformly effective. One important uncertainty is to what extent thalamic subregions other than the ANT are recruited earlier and more prominently in the propagation of seizures in patients with presumed temporal lobe epilepsy (TLE). To address this unknown, we studied 11 patients with clinical manifestations of TLE planned to undergo invasive stereo-encephalography (sEEG) monitoring. We extended cortical electrodes to reach thalamic nuclear subdivisions in the anterior (ANT), middle (mediodorsal) and or posterior (pulvinar) sites. This multisite thalamic sampling was without any adverse events. Intracranial EEG (iEEG) recordings confirmed seizure onset in medial temporal lobe, insula, orbitofrontal and temporal neocortical sites, thereby highlighting the importance of iEEG for more accurate localization of seizure foci. Visual review of EEGs documented early and prominent involvement of specific thalamic sites. Seizures originating from the same brain origin produced a stereotyped thalamic EEG signature. Visual review of EEGs, validated with single-pulse corticothalamic evoked potentials, documented early and prominent involvement of thalamic sites that would have not been predicted given the anatomy of seizure onset zones. Pulvinar was involved earlier and more prominently than other sampled nuclear subgroups in 60% of patients, even though all patients had a presumed diagnosis of TLE prior to invasive monitoring. Our findings document the feasibility and safety of multisite sampling from the human thalamus and suggest that the anatomy of thalamic involvement may not be entirely predictable on the basis of clinical information or lobar localization of seizures. Future clinical trials can establish whether offering more personalized targets for thalamic neuromodulation will lead to greater meaningful improvements in outcome. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.11.18.516669v1?rss=1 Authors: Nagle, A., Gerrelts, J. P., Krause, B., Boes, A. D., Bruss, J. E., Nourski, K. V., Banks, M. I., Van Veen, B. Abstract: Multivariate autoregressive (MVAR) model estimation enables assessment of causal interactions in brain networks. However, accurately estimating MVAR models for high-dimensional electrophysiological recordings is challenging due to the extensive data requirements. Hence, the applicability of MVAR models for study of brain behavior over hundreds of recording sites has been very limited. Prior work has focused on different strategies for selecting a subset of important MVAR coefficients in the model and is motivated by the potential of MVAR models and the data requirements of conventional least-squares estimation algorithms. Here we propose incorporating prior information, such as fMRI, into MVAR model estimation using a weighted group LASSO regularization strategy. The proposed approach is shown to reduce data requirements by a factor of two relative to the recently proposed group LASSO method of Endemann et al. (2022) while resulting in models that are both more parsimonious and have higher fidelity to the ground truth. The effectiveness of the method is demonstrated using simulation studies of physiologically realistic MVAR models derived from iEEG data. The robustness of the approach to deviations between the conditions under which the prior information and iEEG data is obtained is illustrated using models from data collected in different sleep stages. This approach will allow accurate effective connectivity analyses over short time scales, facilitating investigations of causal interactions in the brain underlying perception and cognition during rapid transitions in behavioral state. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.10.25.513590v1?rss=1 Authors: Pidnebesna, A., Sanda, P., Kalina, A., Hammer, J., Marusic, P., Vlcek, K., Hlinka, J. Abstract: Intracranial EEG (iEEG) data is a powerful way to map brain function, characterized by high temporal and spatial resolution, allowing the study of interactions among neuronal populations that orchestrate cognitive processing. However, the statistical inference and analysis of brain networks using iEEG data faces many challenges related to its sparse brain coverage, and its inhomogeneity across patients. We review these challenges and develop a methodological pipeline for estimation of network structure not obtainable from any single patient, illustrated on the inference of the interaction among visual streams using a dataset of 27 human iEEG recordings from a visual experiment employing visual scene stimuli. 100 ms sliding window and multiple band-pass filtered signals are used to provide temporal and spectral resolution. For the connectivity analysis we showcase two connectivity measures reflecting different types of interaction between regions of interest (ROI): Phase Locking Value as a symmetric measure of synchrony, and Directed Transfer Function - asymmetric measure describing causal interaction. For each two channels, initial uncorrected significance testing at p less than 0.05 for every time-frequency point is carried out by comparison of the data-derived connectivity to a baseline surrogate-based null distribution, providing a binary time-frequency connectivity map. For each ROI pair, a connectivity density map is obtained by averaging across all pairs of channels spanning them, effectively agglomerating data across relevant channels and subjects. Finally, the difference of the mean map value after and before the stimulation is compared to the same statistic in surrogate data to assess link significance. The analysis confirmed the function of the parieto-medial temporal pathway, mediating visuospatial information between dorsal and ventral visual streams during visual scene analysis. Moreover, we observed the anterior hippocampal connectivity with more posterior areas in the medial temporal lobe, and found the reciprocal information flow between early processing areas and medial place area. To summarize, we developed an approach for estimating network connectivity, dealing with the challenge of sparse individual coverage of intracranial EEG electrodes. Its application provided new insights into the interaction between the dorsal and ventral visual streams, one of the iconic dualities in human cognition. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.10.03.510665v1?rss=1 Authors: Afnan, J., von Ellenrieder, N., Lina, J.-M., Pellegrino, G., Arcara, G., Cai, Z., Hedrich, T., Abdallah, C., Khajehpour, H., Frauscher, B., Gotman, J., Grova, C. Abstract: Background: Magnetoencephalography (MEG) is a widely used non-invasive tool to estimate brain activity with high temporal resolution. However, due to the ill-posed nature of the MEG source imaging (MSI) problem, the ability of MSI to identify accurately underlying brain sources along the cortical surface is still uncertain and requires validation. Method: We validated the ability of MSI to estimate the background resting state activity of 45 healthy participants by comparing it to the intracranial EEG (IEEG) atlas (https://mni-open-ieegatlas.research.mcgill.ca/). First, we applied wavelet-based Maximum Entropy on the Mean (wMEM) as an MSI technique. Next, we converted MEG source maps into intracranial space, by applying a forward model to the MEG reconstructed source maps and estimated virtual IEEG (VIEEG) potentials on each IEEG channel location and quantitatively compared those with actual IEEG signals from the atlas for 38 regions of interest in the canonical frequency bands. Results: The MEG spectra were more accurately estimated in the lateral regions compared to the medial regions. The regions with higher amplitude in the VIEEG than in the IEEG were more accurately recovered. In the deep regions, MEG estimated amplitudes were largely underestimated and the spectra were poorly recovered. Moreover, the MEG largely overestimated oscillatory peaks in the alpha band, especially in the anterior and deep regions. This is possibly due to higher phase synchronization of alpha oscillations over extended regions, exceeding the spatial sensitivity of IEEG but detected by MEG. Importantly, we found that MEG estimated spectra were more comparable to spectra from the IEEG atlas after the aperiodic components were removed. Conclusion: This study identifies brain regions and frequencies for which MEG source analysis is likely to be reliable, a promising step towards resolving the uncertainty in recovering intracerebral activity from non-invasive MEG studies. Copy rights belong to original authors. Visit the link for more info Podcast created by PaperPlayer

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.09.08.507081v1?rss=1 Authors: Li, J., Cao, D., Yu, S., Wang, H., Imbach, L., Stieglitz, L., Sarnthein, J., Jiang, T. Abstract: Working memory (WM) is the ability to actively maintain information for a short time and is central to human behavior. Rodent studies have proposed that hippocampal-entorhinal communication supports WM maintenance. However, the exact neural mechanisms of this interaction in WM remains unclear in humans. To address these questions, we combined machine learning analyses with intracranial electroencephalography (iEEG) recordings from the hippocampus and the entorhinal cortex (EC) in human participants, who maintained a set of letters in their WM. We found that WM maintenance was accompanied by elevated bidirectional hippocampal-EC information exchange via the theta band (2-8 Hz) and bidirectional cross-region theta-gamma phase-amplitude coupling (PAC). Further decoding analyses showed that the unidirectional inter-regional communication, with both theta oscillations in the hippocampus modulating EC gamma activity and theta band-coordinated information flow from the hippocampus, could decode correct performance at the level of participants. Taken together, our results demonstrate that theta functional coupling in the hippocampal-EC supports the maintenance of WM information via a specific pattern of frequency and direction. This connectivity-based coding could shed light on the neural mechanisms of WM processing. Copy rights belong to original authors. Visit the link for more info Podcast created by PaperPlayer

La presidenta del IEEG defendió la decisión de ese órgano que sacó de la terna a un varón que había obtenido uno de los 3 mejores promedios de calificación para aspirar a la Contraloría Interna para meter a una mujer ¿fue un exceso? #PólvoraEnLínea #SegundaEmisión

Hoy rindió protesta Brenda Canchola Elizarraraz como consejera presidenta del IEEG, es la primera mujer al frente del organismo en 26 años, ¿cómo será la cohesión interna? #PólvoraEnLínea #SegundaEmisión

La comisión de Vinculación con los Organos Públicos Locales del INE designó a Brenda Canchola como la más idónea para presidir el consejo del IEEG durante 7 años, solo falta una aduana #PólvoraEnLínea #SegundaEmisión

El Consejo General del IEEG tendrá un consejero o consejera presidente interino durante octubre, pues se pospuso la elección del sucesor de Mauricio Guzmán, quien ya terminó su periodo #PólvoraEnLínea #SegundaEmisión

Aunque apenas mañana se vota el acuerdo y es apenas el inicio, se ve venir una impugnación de Movimiento Ciudadano, ¿va a haber debate en la mesa del IEEG? Se queda en el tintero.. #PólvoraEnLínea #SegundaEmisión

Ayer lunes por la noche comenzó a circular el proyecto que el Consejo General del IEEG prepara para mañana miércoles que será la sesión para la asignación de las plurinominales, ¿cómo queda el reparto? #PólvoraEnLínea #PrimeraEmisión

Este domingo el IEEG hizo el cómputo final y no hay mayores sorpresas, los votos y porcentajes acreditan que el PAN tiene 21 distritos… #PólvoraEnLínea #PrimeraEmisión

Hoy fue la sesión especial del IEEG en la que arrancaron los cómputos distritales y municipales, el voto por voto será en solo en casos especiales, la duración será indefinida… #PólvoraEnLínea #PrimeraEmisión

El formato del debate del IEEG permitirá mayor interacción de los candidatos, aunque hay cosas que se deberán ajustar, ya es un pasito… ojalá que la apuesta sea a las propuestas #PólvoraEnLínea #SegundaEmisión

¿Los debates del IEEG realmente posicionan a los candidatos que asisten?, ¿hay ganadores y perdedores?, ¿quién debe ganar: el candidato o la ciudadanía?, ¿el formato lo permite? #PólvoraEnLínea #PrimeraEmisión

Ya comienzan los debates de candidatos organizados por el IEEG, ¿cómo vendrá el menú?, ¿habrá propuestas, cómos, encontronazos?, sin duda habrá algunos muy interesantes… #PólvoraEnLínea #SegundaEmisión

Desde el arranque del proceso electoral, varios partidos se han quejado del árbitro; ayer, el Tribunal Electoral resolvió que se violaron garantías de audiencia de parte del IEEG hacia Morena y su resolución fue a partir de información que no le habían requerido #PólvoraEnLínea #PrimeraEmisión

El tema del contacto físico en las campañas de los candidatos a la alcaldía de León ha superado las expectativas que había, ¿se está cumpliendo el protocolo que marca el IEEG por la pandemia? #PólvoraEnLínea #SegundaEmisión

Según Inmersa, el PAN lleva ventaja en prácticamente la mayoría de los distritos federales; el 20 de abril arrancan campañas de diputaciones locales y el lunes el IEEG dictaminará lo que ocurre con las fórmulas propuestas por los partidos #PólvoraEnLínea #PrimeraEmisión

El fin de semana estuvo movidito porque ya fue el cierre de registros de candidatos a diputados locales; además, el IEEG solicitó al PAN unos ajustes de ubicación, ¿cómo es posible? #PólvoraEnLínea #PrimeraEmisión

Luego de que el IEEG aprobó solo 34 planillas de Morena a Ayuntamientos, ¿cómo queda el tema de paridad?, ¿hay algún tema que ajustar? A ver qué dice el árbitro electoral #PólvoraEnLínea #SegundaEmisión

A partir de que los partidos entreguen sus papeles tienen 72 horas para subsanar alguna falla o insuficiencia, mientras, el IEEG tiene hasta el 4 de abril para pronunciarse sobre la procedencia de los registros #PólvoraEnLínea #SegundaEmisión

Die Form von Kirche muss sich immer wieder an die Gegebenheiten der Zeit anpassen und hat sich auch immer wieder an die Gegebenheiten der Zeit angepasst. Das ist eine Binsenweisheit. Die viel schwierige Frage ist dabei: Wie ist die Form für Kirche in dieser Zeit? Über diese Frage rede ich mit Hans Hermann Pompe, Referent für Mission und Kirchenentwicklung der Arbeitsstelle für missionarische Kirchenentwicklung und diakonische Profilbildung (midi) und Michael Herbst, Professor an der Universität Greiwswald und Leiter des Instituts zur Erforschung von Evangelisation und Gemeindeentwicklung (IEEG). Wir sind als einzelne Ortsgemeinde häufig völlig überfordert vorzuhalten, was alles zum Vollprogramm einer Kirchengemeinde gehört. Michael Herbst, IEEG Wir reden über die Vor- und Nachteile der regionalen und lokalen Ebene für die Kirchenentwicklung und wieso in der Zusammenarbeit eine enorme Stärke liegt. Denn das Dilemma ist deutlich: Menschen sind nicht mehr lokal verankert, sondern mobil. Während die Kirchgemeindestruktur noch in Straßenzügen denkt, sind Menschen an vielen Orten daheim. Zeug*innen der Christen im Alltag, sind für die meisten Menschen heute, der erste und wichtigste Zugangsort. Und da sind wir ganz, ganz schwach. Hans-Hermann, Pompe Und wie schaffen es eigentlich Gemeinden Strahlkraft zu entwickeln, sodass sie überlokal wahrgenommen werden? Die Frage nach Kirchenentwicklung ist auch eine Frage nach Mission und Evangelisation. Links Institut zur Erforschung von Evangelisation und Gemeindeentwicklung https://ieeg.uni-greifswald.de/

Luego de que Luis Gerardo González sugirió que los aficionados del Club León aportaran para pagar la renta del estadio, y ahora que avaló el aumento a los sueldos de los consejeros del IEEG, ¿qué se espera del liderazgo? ¿habrá contrapeso? #PólvoraEnLínea #SegundaEmisión

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.25.265520v1?rss=1 Authors: Mondino, A., Cavelli, M., Gonzalez, J., Osorio, L., Castro-Zaballa, S., Costa, A., Vanini, G., Torterolo, P. Abstract: The sleep-wake cycle is constituted by three behavioral states: wakefulness (W), non-REM (NREM) and REM sleep. These states are associated with drastic changes in cognitive capacities, mostly determined by the function of the thalamo-cortical system. Thalamo-cortical activity can be examined by means of the intra-cranial electroencephalogram (iEEG). With the purpose to study in depth the basal activity of the iEEG in adult rats, we analyzed the spectral power and coherence of the iEEG during W and sleep in the paleocortex (olfactory bulb), as well as in motor, somatosensory and visual neocortical areas. We also analyzed the laterality (right Vs. left hemispheres) of the signals, as well as the iEEG in function of the light and dark phases. We found that the iEEG power and coherence of the whole spectrum were largely affected by behavioral states and were highly dependent on the cortical areas recorded. We also determined that there are night/day differences in power and coherence during sleep, but not in W. Finally, while we did not find right/left differences in power either in W or sleep, we observed that during REM sleep intra-hemispheric coherence differs between both hemispheres. We conclude that the iEEG dynamics is highly dependent on the cortical area and behavioral states. We also determine that there are light/dark phases disparities in the iEEG that emerge during sleep, and that intra-hemispheric connectivity differs between both hemispheres only during REM sleep. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.07.24.220566v1?rss=1 Authors: Das, A., de los Angeles, C., Menon, V. Abstract: Investigations using noninvasive functional magnetic resonance imaging (fMRI) have provided significant insights into the unique functional organization and profound importance of the human default mode network (DMN), yet these methods are limited in their ability to resolve network dynamics across multiple timescales. Electrophysiological techniques are critical to address these challenges, yet few studies have explored the neurophysiological underpinnings of the DMN. Here we investigate the brain-wide electrophysiological organization of the DMN in a common large-scale network framework consistent with prior fMRI studies. We used brain-wide intracranial EEG (iEEG) recordings, and evaluated intra- and cross-network interactions during the resting-state and cognition. Our analysis revealed significantly greater intra-DMN phase iEEG synchronization in the slow-wave (< 4 Hz) while DMN interactions with other brain networks was higher in all higher frequencies. Crucially, slow-wave intra-DMN synchronization was observed in the task-free resting-state and during verbal memory encoding and recall. Compared to resting-state, intra-DMN phase synchronization was significantly higher during both memory encoding and recall. Slow-wave intra-DMN phase synchronization increased during successful memory retrieval, highlighting its behavioral relevance. Finally, analysis of nonlinear dynamic causal interactions revealed that the DMN is a causal outflow network during both memory encoding and recall. Our findings identify dynamic spectro-temporal network features that allow the DMN to maintain a balance between stability and flexibility, intrinsically and during task-based cognition, provide novel insights into the neurophysiological foundations of the human DMN, and elucidate network mechanisms by which it supports cognition. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.07.22.216416v1?rss=1 Authors: Henin, S., Shankar, A., Borges, H., Flinker, A., Doyle, W., Friedman, D., Devinsky, O., Buzsaki, G., Liu, A. Abstract: We describe the spatiotemporal course of cortical high-gamma activity (HGA), hippocampal ripple activity and interictal epileptiform discharges (IEDs) during an associative memory task in 15 epilepsy patients undergoing invasive electroencephalography (iEEG). Successful encoding trials were significantly greater HGA in hippocampus and frontal regions. Successful recall trials manifested sustained HGA in occipital pole and hippocampus compared to failed responses. Hippocampal ripple rates were greater during successful encoding and retrieval trials. IEDs during encoding were associated with decreased odds of remembering in hippocampus (-19%), temporal pole (-18%) or middle temporal gyrus (-15%). Hippocampal IEDs during retrieval predicted 33% decreased odds of remembering. Odds of remembering were further reduced if IEDs occurred during the 500-2000 ms window of encoding or retrieval. Hippocampal IEDs were followed by a transient decrease in ripple rate. We hypothesize that IEDs impair associative memory in a regionally and temporally specific manner by decreasing physiologic hippocampal ripples necessary for effective encoding and recall. Because dynamic memory impairment arises from pathological IED events competing with physiological ripples, IEDs represent a promising therapeutic target for memory remediation in patients with epilepsy. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.06.28.176222v1?rss=1 Authors: Charupanit, K., Sen-Gupta, I., Lin, J. J., Lopour, B. A. Abstract: Objective: Studies of high frequency oscillations (HFOs) in epilepsy have primarily tested the HFO rate as a biomarker of the seizure onset zone (SOZ), but the rate varies over time and is not robust for all individual subjects. As an alternative, we tested the performance of HFO amplitude as a potential SOZ biomarker using two automated detection algorithms. Methods: HFOs were detected in intracranial electroencephalogram (iEEG) from 11 patients using a machine learning algorithm and a standard amplitude-based algorithm. For each detector, SOZ and non-SOZ channels were classified using the rate and amplitude of high frequency events, and performance was compared using receiver operating characteristic curves. Results: The amplitude of detected events was significantly higher in SOZ. Across subjects, amplitude more accurately classified SOZ/non-SOZ than rate (higher values of area under the ROC curve and sensitivity, and lower false positive rates). Moreover, amplitude was more consistent across segments of data, indicated by lower coefficient of variation. Conclusion: As an SOZ biomarker, HFO amplitude offers advantages over HFO rate: it exhibits higher classification accuracy, more consistency over time, and robustness to parameter changes. Significance: This biomarker has the potential to increase the generalizability of HFOs and facilitate clinical implementation as a tool for SOZ localization. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.06.02.129676v1?rss=1 Authors: Magnotti, J. S., Wang, Z., Beauchamp, M. S. Abstract: Direct recording of neural activity from the human brain using implanted electrodes (iEEG, intracranial electroencephalography) is a fast-growing technique in human neuroscience. While the ability to record from the human brain with high spatial and temporal resolution has advanced our understanding, it generates staggering amounts of data: a single patient can be implanted with hundreds of electrodes, each sampled thousands of times a second for hours or days. The difficulty of exploring these vast datasets is the rate-limiting step in discovery. To overcome this obstacle, we created RAVE ("R Analysis and Visualization of iEEG"). All components of RAVE, including the underlying "R" language, are free and open source. User interactions occur through a web browser, making it transparent to the user whether the back-end data storage and computation is occurring on a local machine, a lab server, or in the cloud. Without writing a single line of computer code, users can create custom analyses, apply them to data from hundreds of iEEG electrodes, and instantly visualize the results on cortical surface models. Multiple types of plots are used to display analysis results, each of which can be downloaded as publication-ready graphics with a single click. RAVE consists of nearly 50,000 lines of code designed to prioritize an interactive user experience, reliability and reproducibility. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.05.27.120097v1?rss=1 Authors: Tan, R. J., Rugg, M. D., Lega, B. C. Abstract: Human data collected using noninvasive imaging techniques have established the importance of parietal regions towards episodic memory retrieval, including the angular gyrus and posterior cingulate cortex. Such regions comprise part of a putative core episodic retrieval network. In free recall, comparisons between contextually appropriate and inappropriate recall events (i.e. prior list intrusions) provide the opportunity to study memory retrieval networks supporting veridical recall, and existing findings predict that differences in electrical activity in these brain regions should be identified according to the accuracy of recall. However, prior iEEG studies, utilizing principally subdural grid electrodes, have not fully characterized brain activity in parietal regions during memory retrieval and have not examined connectivity between core recollection areas and the hippocampus or prefrontal cortex. Here, we employed a data set obtained from 100 human patients implanted with stereo EEG electrodes for seizure mapping purposes as they performed a free recall task. This data set allowed us to separately analyze activity in midline versus lateral parietal brain regions, and in anterior versus posterior hippocampus, to identify areas in which retrieval-related activity predicted the recollection of a correct versus an incorrect memory. With the wide coverage afforded by the stereo EEG approach, we were also able to examine interregional connectivity. Our key findings were that differences in gamma band activity in the angular gyrus, precuneus, posterior temporal cortex, and posterior (more than anterior) hippocampus discriminated accurate versus inaccurate recall as well as active retrieval versus memory search. The left angular gyrus exhibited a significant power decrease preceding list intrusions as well as unique phase-amplitude coupling properties, whereas the prefrontal cortex was unique in exhibiting a power increase during list intrusions. Analysis of connectivity revealed significant hemispheric asymmetry, with relatively sparse left- sided functional connections compared to the right hemisphere. One exception to this finding was elevated connectivity between the prefrontal cortex and left angular gyrus. This finding is interpreted as evidence for the engagement of prefrontal cortex in memory monitoring and mnemonic decision-making. Copy rights belong to original authors. Visit the link for more info

  In May 2019 Izzy Lugo, Co-Founder and COO at Urban Misfit Ventures, joined me on Episode 119 of the Screw the Naysayers podcast. Izzy is also a public speaker and co-host of the Strange on Purpose Podcast.  Urban Misfit Ventures is a holding company that owns one of Milwaukee's fastest growing startups. IEEG, a Content Marketing firm as well as an events company called the mkemisfits. Izzy is also a huge foodie, sneakerhead and sports fan.  Today I share 7 truths that Izzy shared about his experiences as a startup entrepreneur (along with my own comments). I missed my five minute goal by 2 minutes but the content is gold. Enjoy...  

Markus Weimer ist Pfarrer der evangelischen Kirchengemeinde Böhringen am Bodensee. Außerdem ist er im Leitungsteam von Church Convention. Zusammen mit seiner Gemeinde möchte er eine Quellgemeinde sein. Was das genau ist und wie sie das umsetzen möchten, haben wir unter anderem in der Episode besprochen. Außerdem geht es auch ganz viel darum, was wir aus der anglikanischen Kirche lernen können. Unsere Webseite: https://ecclesiopod.de Podcast bei Instagram: https://www.instagram.com/ecclesiopod/ Shownotes: ev. Kirche Böhringen: www.ekiboe.de churchconvention: https://www.churchconvention.de/cc/ IEEG: https://ieeg.uni-greifswald.de Markus Artikel im Willow Creek Magazin: https://bit.ly/37kmxiF Atlas neuer Gemeindeformen: https://bit.ly/30LT1Qc Bücher: Mission Zukunft, Michael Diener u. Ulrich Eggers: https://amzn.to/38ybiTI Kirche und Milieu, Milieusensible Kommunikation des Evangelium, u.a. von Markus Weimer: https://amzn.to/30NU6XC Next Generation Leader, Andy Stanley: https://amzn.to/2sPDbrf Lebendig!: Vom Geheimnis mündigen Christseins, Michael Herbst: https://amzn.to/2TQDlK0 Vielen Dank fürs zuhören. Es würde mir und dem Podcast sehr weiterhelfen, wenn du den Podcast bewerten würdest und deinen Freunden davon erzählst. Ich freue mich außerdem über Feedback. Schreib mir einfach auf Instagram oder per Mail an: gebhardtsilas@gmail.com

En diciembre de 2020, afirmó López Obrador que el Sistema Nacional de Salud funcionará a toda máquina, con atención médica y medicamentos gratuitos. No va a salir gratis, de algún lado tienen que financiarse, solo hay dos caminos: endeudarse o mejorar la recaudación. En otro tema quiénes son los expertos en materia electoral para continuar el impulso del IEEG. Sobre todo algunas mujeres, por lo que es necesario ver si el próximo presidente del instituto será mujer, pero no solo por el simple hecho de serlo, sino por sus méritos.

Izzy Lugo is the Co-Founder and COO at Urban Misfit Ventures, Brand & Content Strategist, Public Speaker and co-host of the Strange on Purpose Podcast. Urban Misfit Ventures is a holding company that owns one of Milwaukee's fastest growing startups. IEEG, a Content Marketing firm as well as an events company called the mkemisfits. Izzy is also a huge foodie, sneakerhead and sports fan. In this episode Izzy explains: What the term misfits means to him Why we should not shame people for being employees Why showing only the highlights on our entrepreneurial journey is a disservice to potential entrepreneurs Why the Misfits continue to invest in giving out high quality free content The importance of aligning yourselves with the right people That at times the four Misfit founders couldn’t pay themselves Why he feels they were damn lucky (note: they weren't) Why you have to play the long game How they select new employees Why persistence wears down resistance And the one thing the misfits are most proud of This is a candid and unvarnished look into the entrepreneurial journey. You can reach Izzy at: LinkedIn: https://www.linkedin.com/in/israellugoiii/   Please do not hesitate to reach out to me. I’d love to hear your thoughts, comments, and stories, or just make a connection.Email-  tim@screwthenaysayers.com Facebook- https://www.facebook.com/stnwithtimalison/ Instagram- https://www.instagram.com/screwthenaysayers/ LinkedIn- https://www.linkedin.com/in/tim-alison/ Screw The Naysayers- www.screwthenaysayers.com

Izzy Lugo is COO at Urban Misfit Ventures, an 8-month-old, start-up holding company that Izzy confesses “pivots a lot.” One agency subsidiary, IEEG, specializes in storytelling and influencer marketing – often by creating a video to tell a brand's story. The influencer marketing portion of their work is based on stories told by influencers, but the influencers are Urban Misfit Venture's employees, each of whom has a massive individual following. Because the employees are the influencers, they can consult with clients and carefully craft the messages that need to be presented. No paying an influencer and trusting that individual to say “the right thing.” IEEG knows what message it wants to send . . . and knows it is going to get it. Urban Misfit Ventures' clients include Milwaukee's professional sports teams and national and international clothing and design brands, who are amazed that the agency and the influencers are one and the same. The second Urban Misfit Ventures' subsidiary, MKE Misfits, is an events company that tells the client's brand story, is very involved in that story, and then provides “quirky” experiential promotions to differentiate itself and its client companies. The company has a major reputation in the Milwaukee area. Urban Misfit Ventures is planning to introduce a number of other specialty subsidiaries I 2019. How did it all start? After a period of separate careers, Quentin, Izzy's college roommate, had met with two of the company's other founders, and then approached Izzy to pitch the idea of Urban Misfit Ventures. After an hour conversation, Izzy was on board, and two weeks later, he quit his job at the bike share. In eight months, the team has grown to 10 employees, including interns. When they started, they traded services for their space at a co-working space, truly starting from scratch. Izzy can be reached on his company's website at: urbanmisfitventures.com, as can anything related to IEEG or MKE Misfits. His company is also on LinkedIn and Instagram. Izzy, Israel Lugo III uses @IzzyLugo for all his handles..

From $- 900 in his bank account to full-time entrepreneur, Quentin Allums has demonstrated tremendous resilience in his path to starting the Urban Misfit Ventures. Talking to Quentin, I realized it's not about who believes in you. It's about how badly do you believe in yourself. When you feel like you're on the brink of failure, do you give up? Or do you inch closer to see what could be past that next horizon? Quentin is the Chief Executive Officer & Co-Founder of Urban Misfit Ventures; which owns IEEG, a storytelling company, and MKE Misfits a community & events company based out of Milwaukee. He was one of the first LinkedIn video storytellers & have since used the platform to accumulate millions of views and travel the world for speaking engagements such as VidCon 2018 and TEDx. In this episode, we talk about: ⚡️The Highs and Lows of Entrepreneurship ⚡️How to Build a Good Team ⚡️The Value Pivoting ⚡️How to Build an Online Community ⚡️ Why You Should Invest in People Quentin's Links: LinkedIn: https://www.linkedin.com/in/tagjustq/ Instagram: https://www.instagram.com/tagjustQ/ YouTube: https://www.youtube.com/user/CloudofMusiQ/ Or you can find me on just about any platform @tagJustQ Connect with me: linkedin.com/in/tiffanyparra/ Follow me on IG: @tiffanyparra_ $upport the podcast: www.patreon.com/work_in_progress Join my community for podcasters: bit.ly/LIpodcasts Want to know what gear I use to produce the podcast? kit.com/TiffanyParra Tune in next Wednesday Nov 7th at 9 PM PST for another Real Talk livestream. --- Support this podcast: https://anchor.fm/work-in-progress/support

Milwaukee Misfits, An events company, community and content team owned by Urban Misfit Ventures. MKE is made up of a collective of entrepreneurs, influencers, and Misfits creative STORYTELLING to inspire action. Brands partner with them to tap into our community and reach, create compelling visual stories, and build brand awareness. Quentin Allums is a top LinkedIn video creator, personal branding strategist, storyteller, and speaker. He has amassed over 3 million content views on the platform in a span of 8 months and is the creator of the popular LinkedIn show #justQ. Israel is the COO, a keynote speaker & handles all partnerships for IEEG & the MKEMisfits team. Previously the Director of Corporate Partnerships with Roc Ventures, he has also worked with organizations such as The Milwaukee Bucks and The Milwaukee Brewers. Eric is a public speaker, visual storyteller, and a top LinkedIn video creator. His journey began in the esports industry and with that has not only built a strong personal brand but regularly has work seen by over 5 million eyes collectively. Brema is one of Milwaukee's most popular Instagram influencers, also known as Optic Legacy. He is a videographer, photographer & brand strategist. He has amassed over 50k followers and has partnered with brands across the globe including Google, Chrome Industries, Red Bull, Movement Watch & more.- https://www.mkemisfits.com/- https://www.linkedin.com/in/tagjustq/- https://www.linkedin.com/in/izzylugo/- https://www.linkedin.com/in/didslive/- https://www.linkedin.com/in/brema-brema-6a5b23162/Please do NOT hesitate to reach out to me on LinkedIn, Instagram, or via email mark@vudream.comLinkedIn - https://www.linkedin.com/in/mark-metry/Instagram - https://www.instagram.com/markmetry/Twitter - https://twitter.com/markymetryMedium - https://medium.com/@markymetryFacebook - https://www.facebook.com/Humans.2.0.PodcastMark Metry - https://www.markmetry.com/Humans 2.0 Twitter - https://twitter.com/Humans2Podcast

Milwaukee Misfits, An events company, community and content team owned by Urban Misfit Ventures. MKE is made up of a collective of entrepreneurs, influencers, and Misfits creative STORYTELLING to inspire action. Brands partner with them to tap into our community and reach, create compelling visual stories, and build brand awareness. Quentin Allums is a top LinkedIn video creator, personal branding strategist, storyteller, and speaker. He has amassed over 3 million content views on the platform in a span of 8 months and is the creator of the popular LinkedIn show #justQ. Israel is the COO, a keynote speaker & handles all partnerships for IEEG & the MKEMisfits team. Previously the Director of Corporate Partnerships with Roc Ventures, he has also worked with organizations such as The Milwaukee Bucks and The Milwaukee Brewers. Eric is a public speaker, visual storyteller, and a top LinkedIn video creator. His journey began in the esports industry and with that has not only built a strong personal brand but regularly has work seen by over 5 million eyes collectively. Brema is one of Milwaukee’s most popular Instagram influencers, also known as Optic Legacy. He is a videographer, photographer & brand strategist. He has amassed over 50k followers and has partnered with brands across the globe including Google, Chrome Industries, Red Bull, Movement Watch & more.- https://www.mkemisfits.com/- https://www.linkedin.com/in/tagjustq/- https://www.linkedin.com/in/izzylugo/- https://www.linkedin.com/in/didslive/- https://www.linkedin.com/in/brema-brema-6a5b23162/Please do NOT hesitate to reach out to me on LinkedIn, Instagram, or via email mark@vudream.comLinkedIn - https://www.linkedin.com/in/mark-metry/Instagram - https://www.instagram.com/markmetry/Twitter - https://twitter.com/markymetryMedium - https://medium.com/@markymetryFacebook - https://www.facebook.com/Humans.2.0.PodcastMark Metry - https://www.markmetry.com/Humans 2.0 Twitter - https://twitter.com/Humans2Podcast

A continuación se presenta el video completo del DVD interactivo desarrollado para el IEEG.Todos los apartados interactivos y de animación no se pueden mostrar en la pagina web.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.04.16.045716v1?rss=1 Authors: Metzger, B. A., Magnotti, J. S., Wang, Z., Nesbitt, E., Karas, P. J., Yoshor, D., Beauchamp, M. S. Abstract: Experimentalists studying multisensory integration compare neural responses to multisensory stimuli with responses to the component modalities presented in isolation. This procedure is problematic for multisensory speech perception since audiovisual speech and auditory-only speech are easily intelligible but visual-only speech is not. To overcome this confound, we developed intracranial encephalography (iEEG) deconvolution. Individual stimuli always contained both auditory and visual speech but jittering the onset asynchrony between modalities allowed for the time course of the unisensory responses and the interaction between them to be independently estimated. We applied this procedure to electrodes implanted in human epilepsy patients (both male and female) over the posterior superior temporal gyrus (pSTG), a brain area known to be important for speech perception. iEEG deconvolution revealed sustained, positive responses to visual-only speech and larger, phasic responses to auditory-only speech. Confirming results from scalp EEG, responses to audiovisual speech were weaker than responses to auditory-only speech, demonstrating a subadditive multisensory neural computation. Leveraging the spatial resolution of iEEG, we extended these results to show that subadditivity is most pronounced in more posterior aspects of the pSTG. Across electrodes, subadditivity correlated with visual responsiveness, supporting a model in visual speech enhances the efficiency of auditory speech processing in pSTG. The ability to separate neural processes may make iEEG deconvolution useful for studying a variety of complex cognitive and perceptual tasks. Copy rights belong to original authors. Visit the link for more info