Podcasts about Pompe

Nicola Longo MD, PhD, and Mark Roberts, MD Nicola Longo MD, PhDProfessor and Vice Chair of Human Genetics,Allen and Charlotte Ginsburg Chair in Precision Genomic Medicine,Division of Clinical Genetics, Department of Human Genetics,University of California at Los Angeles (UCLA), Los Angeles, CA, USAMark Roberts, MDProfesor and Consultant Neurologist,University of Manchester, Manchester, UKResearch Lead for Adult Metabolic Medicine at Salford Care Organisation, Manchester, UKDrs. Longo and Roberts discuss the current status of gene therapies in rare neuromuscular disorders in this eight-part podcast series. This is derived from the symposium that was presented at World Symposium 2025 in San Diego, California on February 4th through 7th, 2025 and is intended for healthcare professionals only. This podcast includes information about investigational compounds that do not yet have a regulatory approval or authorization for a specific indication. The safety and efficacy of the agents under investigation have not been established and contents of this podcast shall not be used in any manner to directly or indirectly promote or sell the product for unapproved uses. The views, thoughts, and opinions expressed in this presentation belong solely to the author and are subject to change without notice.The contents of this presentation do not constitute an endorsement of any product or indication by Astellas. In this part, Dr. Roberts will discuss vectors, different strategies, modes of administration and targets in gene replacement therapies.Mark Roberts, MDNow in the broader sense, gene replacement therapy seeks to actually deliver genetic material directly into the host cell to influence gene expression. In the most simple idea, one of course has a vector, this is most commonly but not exclusively a virus, which can then be given intravenously for example, and can hope to potentially correct the condition within the individual cells using novel transgenes. Suitable candidate conditions for this as examples of genetic conditions are now well understood. And crucially, this applies not only towards some more recessive, but dominant and even accident conditions.Across the piece, one can see for example, mitochondrial problems, spinal muscular atrophy as is well known, X-linked myotubular myopathy, Duchenne muscular dystrophy, a very common condition affecting one in 3000 male individuals, Pompe disease of course, an important focus of the meeting here, but other very common conditions, for example, cystic fibrosis, immunological conditions and perhaps obviously very crucial in early work on gene therapy, hemophilia.Let's now think about the approaches to gene therapy. One can seek to work at the DNA level and gene replacement. In essence, one is trying to put a new transgene through into the nucleus that will ultimately be transcribed and translated and produce the important functional protein that is lost. Gene editing which is a very exciting new technology or CRISPR technology actually seeks to actually modify in vivo the actual mutations that are responsible for the pathogenic production of abnormal proteins and correcting these and actually producing a more normalized protein.But of course there are also RNA approaches where one seeks to actually repair the mRNA transcripts copied from the mutated gene. For example, this may be a novel approach that could be extremely useful in myotonic dystrophy, a multisystem condition. When we talk about the viral vectors, predominantly we're talking about viruses. Those such as adenoviruses and AAV viruses which have the virtue of not integrating into the host genome or at least not in a large amount, and those which deliberately seek to integrate into host genome such as retroviral or lentiviral systems that may be particularly useful for ex vivo systems.There are of course other ways to get genetic payloads into the nucleus, various polymers, nanoparticles and even cell penetrating peptides. Nanoparticles in particular is certainly on the ascendant. That being said, in a recent review of the clinical trials in gene therapy, it was certainly the viral vectors that stood out both in direct gene replacement with lentivirus and AAV, but also actually as delivery systems, for example, for gene editing. An example of what one is seeking to do with AAV, so of course one seeking to remove the native DNA, insert the new transgene directly into the vector and of course keen to make sure that there's a high transmission into the capsid producing a recombinant AAV, which then can be given as a treatment and hopefully produce a therapeutic increase in the functional protein that is deficit in the disorder.In the next part, Dr. Roberts will discuss immune responses and other safety concerns related to gene therapies.

Nicola Longo MD, PhD, and Mark Roberts, MDNicola Longo MD, PhDProfessor and Vice Chair of Human Genetics,Allen and Charlotte Ginsburg Chair in Precision Genomic Medicine,Division of Clinical Genetics, Department of Human Genetics,University of California at Los Angeles (UCLA), Los Angeles, CA, USAMark Roberts, MDProfesor and Consultant Neurologist,University of Manchester, Manchester, UKResearch Lead for Adult Metabolic Medicine at Salford Care Organisation, Manchester, UKDrs. Longo and Roberts discuss the current status of gene therapies in rare neuromuscular disorders in this 8-part podcast series. This is derived from the symposium that was presented at World Symposium 2025 in San Diego, California on February 4th-7th 2025 and is intended for healthcare professionals only.This podcast includes information about investigational compounds that do not yet have a regulatory approval or authorization for a specific indication. The safety and efficacy of the agents under investigation have not been established and contents of this podcast shall not be used in any manner to directly or indirectly promote or sell the product for unapproved uses.The views, thoughts, and opinions expressed in this presentation belong solely to the author and are subject to change without notice. The contents of this presentation do not constitute an endorsement of any product or indication by Astellas. In this part, Dr. Roberts will discuss immune responses and other safety concerns related to gene therapies.Mark Roberts, MDUndoubtedly, the immune system is a major issue in these patients. It would be fantastic if we could immunotolerize our patients and indeed prevent the rejection of the therapy. We've talked about the fact that these are viral vectors and of course there may be high seroprevalence of antibodies to these viral vectors, and it's very important in the pre-screening of patients who might be eligible to understand that at the beginning. These of course can have developed over the years and of course can be part of immunological memory and therefore extremely difficult and probably impractical to actually shift.On giving the treatment though as I think we're all aware there is this problem of the innate immunity and potential therefore for acute toxicities and then a learned or adaptive response with cytotoxic T cells and antibodies which may of course become high tighter neutralizing antibodies and potentially antibodies not only against the viral vector, even the functional protein, even the transgene are all theoretical possibilities with time. The capsid, the transgene, and even the protein product can all potentially induce an immunological event. Of course, all of these would lead to both potential patient changes and then a lack of efficacy of the treatment.Indeed, there have been some serious and indeed fatal problems in the gene therapy development program as I think we're all aware. Though many of these are thankfully been overcome. Spinal muscular atrophy has a gene therapy which is licensed, but there were early patients who actually had significant problems. A patient of just 6 months of age who developed kidney failure, two other patients who actually developed liver failure.In Duchenne muscular dystrophy, a very common condition, again there were significant issues and crucially in these patients who all have cardiomyopathy, it was heart failure and cardiac arrest that were big concerns and pulmonary edema and this was seen even with a CRISPR-based technology and is perhaps is best known but has been addressed the excellent myotubular myopathy patients, four patients died and crucially quite a long time after the gene therapy emphasizing the need to monitor these patients extremely carefully and these patients died of cholestatic liver failure albeit that they had a degree of liver dysfunction.That's changed our screening of course of patients, we're now all looking in myotubular patients for liver involvement and Rett syndrome as well. Now these immunoprophylaxis treatment regimes to hopefully try and reduce the immunological reaction against the gene are certainly evolving.This is just a summary of some of the other immunosuppressive regimes used in other disorders, for example, spinal muscular atrophy, but Pompe and MPS as examples of LSDs. Certainly these regimes will continue to evolve and are going to be very important in seeking to make sure that these treatments are effective. It reminds me somewhat of what's happened with enzyme replacement therapy that the use of these immunological strategies in infants has revolutionized the utility of those treatments in early patients.In the next part, Dr. Roberts will discuss lessons learned from gene therapy trials.

Nicola Longo MD, PhD, and Mark Roberts, MDDrs. Longo and Roberts discuss the current status of gene therapies in rare neuromuscular disorders in this eight-part podcast series. This is derived from the symposium that was presented at WORLDSymposium 2025 in San Diego, California on February 4th-7th 2025 and is intended for healthcare professionals only.This podcast includes information about investigational compounds that do not yet have a regulatory approval or authorization for a specific indication. The safety and efficacy of the agents under investigation have not been established and contents of this podcast shall not be used in any manner to directly or indirectly promote or sell the product for unapproved uses.The views, thoughts, and opinions expressed in this presentation belong solely to the author and are subject to change without notice. The contents of this presentation do not constitute an endorsement of any product or indication by Astellas. In this part, Dr. Longo will discuss the current treatment landscape and limitations in lysosomal disorders.Nicola Longo MD, PhDWhat I want to do today, is just place gene replacement therapy within the current landscape of lysosomal storage disorder treatment therapy. Gene therapy obviously has the potential of treating lysosomal disorder to correct the root cause of lysosomal storage disorder. The gene is defective, and what happen is that you can potentially either fix the gene or bypass the lack of the genetic product. But there are already therapies that are existing and are functioning. Obviously, in many cases, the lysosomal disorder is caused by defective production of an enzyme, which is defective.We can either replace the enzyme with enzyme replacement therapy, or provide chaperone for specific mutations that retain the synthesis of the enzyme, that however is not very functional. Another avenue that it is being reported is the utilization of substrate reduction therapy. A substrate accumulates, you prevent the synthesis of the substrate to reduce the accumulation of toxic material. What we know now is that this is not enough to produce many lysosomal disorders. In many cases, the lysosomal disorder result sometime in impairment of intracellular trafficking, and sometime in the function of other organelles.At the end, it results in the activation of the macrophagic system and inflammation. Already we have some therapy acting at this level. The end result of lysosomal storage disorder, there will be cell suffering and cell death, leading to a progression of the disease, and morbidity and mortality. Now, what therapy do we have available already? Obviously, hematopoietic stem cell transplantation has been around for quite some time.It has been the same thing that we do with gene therapy, except that instead of reintroducing the gene of the subject, we place gene of a subject who is not affected of the disease. This therapy has been proven effective in cases of MPS-1 and alpha-mannosidosis. But in many cases this has to be given way before symptoms start to be affected.Enzyme replacement therapy has been around for quite some time, starting with Gaucher disease, and now that it is available for a list of diseases that are there, so it's like Fabry, Gaucher, Pompe, different types of mucopolysaccharidosis, alpha-mannosidosis, acid lipase deficiency, 1 neuronal ceroid lipofuscinosis, and Niemann-Pick type A and B.Obviously the advantage of this therapy, they give back the enzyme that it is defective. But the disadvantage that many time they cannot enter specialized areas such as the brain. There is already the second generation of enzyme replacement therapy that it is available. With this second generation, some of the newer drugs are more effective in terms of cellular uptake, or in terms of having a prolonged half-life and prolonged activity.Then there are pharmacological chaperone therapy, and the one which is FDA approved is migalastat for Fabry disease, under study is ambroxol for Gaucher disease. The disadvantage of this therapy that only a selected number of mutations respond to this therapy.Substrate reduction therapy has been introduced for Gaucher disease many years ago with miglustat, and it was followed by eliglustat. Both of them are effective, and some of them more effective than other, simply because of the fewer side effects of eliglustat as compared to miglustat. But at the same time, eliglustat does not pass the blood brain barrier.Finally, the newer agents that are already administered, N-acetyl-L-leucine and arimoclomol, both approved for Niemann-Pick type C, they act more on the downstream effect of the lysosomal storage disorder, either by stabilizing neuronal cell activity or by reducing the inflammation that is present in the brain.In the next part, Dr. Longo will discuss gene replacement therapy in lysosomal disorders.

Nicola Longo MD, PhDProfessor and Vice Chair of Human Genetics,Allen and Charlotte Ginsburg Chair in Precision Genomic Medicine,Division of Clinical Genetics, Department of Human Genetics,University of California at Los Angeles (UCLA), Los Angeles, CA, USAMark Roberts, MDProfessor and Consultant Neurologist,University of Manchester, Manchester, UKResearch Lead for Adult Metabolic Medicine at Salford Care Organisation, Manchester, UKDrs. Longo and Roberts discussed the current status of gene therapies in rare neuromuscular disorders in this eight-part podcast series. This is derived from the symposium that was presented at World Symposium 2025 in San Diego, California on February 4th through 7th, 2025, and is intended for healthcare professionals only. This podcast includes information about investigational compounds that do not yet have a regulatory approval or authorization for a specific indication. The safety and efficacy of the agents under investigation have not been established and contents of this podcast shall not be used in any manner to directly or indirectly promote or sell the product for unapproved uses. The views, thoughts, and opinions expressed in this presentation belong solely to the author and are subject to change without notice. The contents of this presentation do not constitute an endorsement of any product or indication by Astellas. In this part, Dr. Longo will discuss ongoing gene therapies in lysosomal disorders.Nicola Longo MD, PhDI'm going to present to discuss some example of ongoing gene therapy for lysosomal disorder. There are gene therapy in development for both Fabry disease and some of this involve ex vivo gene therapy, many others involve systemic administration with an AAV, Gaucher disease type 1 that affect the periphery, and Gaucher disease type 2, where the replacement should occur within the central nervous system because this condition affects the brain. There is already one approved gene therapy for lysosomal disorder, which is for the early onset metachromatic leukodystrophy. This has been approved both in Europe and now even in the United States, which consists of ex vivo gene therapy with the administration of an extra gene that restore the function of the defective enzyme. Now there are many others that are ongoing for the same indication. There are gene therapy programs for GM1 and GM2 gangliosidosis, and at least one for Krabbe disease. It is important to know that some of these condition are actually included in the recommended uniform screening panel. Basically, we would have access to patients in a timely manner for some of these conditions. Then there are several gene therapy under development for the mucopolysaccharidoses, including MPS-IH, MPS-II, MPS-IIIA and MPS-IV.There are different type of lysosomal disorders, the one caused by mutation, integral membrane protein, not enzyme within the lysosome, but protein that are present on the membrane of the lysosome. This gene therapy that have been tested, it is for cystinosis, that it is caused by a defective lysosomal and for Danon disease, which is caused by a deficiency of an integral membrane part. Finally, one lysosomal disorder, which obviously seems a metabolic condition, but it is really not, is glycogen storage disease type 2 or Pompe disease, in which there is the intralysosomal accumulation of glycogen. There are several ongoing clinical trials to try to correct the problem in this condition.Now, I'm going to discuss some of the most advanced program in the lysosomal storage disorder. This include one for Fabry, which is on an accelerated approval pathway with phase 1 and 2 data, one for Gaucher disease type 1. Obviously, I'm going to discuss the one that has been already approved for metachromatic leukodystrophy. There is one for Hunter syndrome, and the difference of the one for Hunter syndrome, it is an example of the direct administration of gene therapy within the central nervous system.Finally, there is one ongoing for glycogen storage disease type 2 or Pompe disease in adult patients. In gene therapy for metachromatic leukodystrophy, it was the first gene therapy approved for lysosomal disorder in human, and this requires harvesting the CD34 cell from affected patient and then introducing the [inaudible 00:04:32] gene back in this cell, and then placing them back inside the patient again. This has been very effective in patients who were treated early, and obviously, the treatment needs to occur before there is irreversible brain damage in this patient.In the next part, Dr. Roberts and Longo will discuss treatment with gene therapies.

Frédérique Lemarchand a répondu à l'appel d'aller habiter en haut de la colline de Vézelay, il y a quelques années déjà. De son appartement, au premier étage d'un immeuble qui surplombe les jolies pentes du Morvan, je suis toujours étonné par la profondeur et la douceur qui, descendues de la colline, pénètrent toute la nature environnante, si loin que mes yeux n'en voient pas la fin.De son appartement, qui est aussi son lieu de création, je suis encore plus étonné par la lumière et la joie qui transforment ce lieu où il fait si bon respirer l'air intense et léger qui vibre, comme dans les œuvres et dans le cœur de cette femme artiste.Cette lumière circule au-delà de cet appartement, dans le courant énergétique puissant qui serpentent sur les quelques dizaines de mètres, entre les murs et sur les pavés d'une ruelle, qui le relient à la Basilique de la Lumière.À quelques dizaines d'heures seulement de Noël, la lumière divine est prête à embraser le monde. C'est avec Frédérique Lemarchand que nous sommes invités à méditer sur la portée merveilleuse et fondamentale de cet évènement unique grâce auquel, à la suite du Christ, nous sommes tous conduits à cette divinité où il nous attend depuis l'origine et pour l'éternité.Qui mieux que Frédérique Lemarchand pour nous parler de la lumière ? Cette femme photophore, qui vit en communion avec Annick de Souzenelle, est une femme prophétique. Sa vision nous aide à surmonter les peurs d'un monde de plus en plus agité, et à accueillir jusqu'au cœur de nos propres ombres la lumière d'un amour aussi tendre qu'irradiant.La grâce, avec Frédérique Lemarchand, est de nous permettre de tourner notre regard à l'intérieur de nous, de nous guider depuis nos ombres jusqu'aux lueurs de la lumière divine qui pulse déjà en nous, et qui rayonne si fortement chez cette femme lumière.Pour découvrir l'oeuvre de Frédérique Lemarchand, cliquer ici.VERS LA MERVEILLEChers amis, chers auditeurs de Zeteo,Des merveilles de mon enfance, celle qui est la plus précieuse, la plus belle la plus mystérieuse à la fois, c'est celle de Noël. Bercé par les récits lus par mes parents, les chants qui résonnaient dans toute la maison ou à la messe de minuit, et les illustrations de mes beaux albums d'histoire religieuse, l'enchantement de l'histoire de cette nuit de Bethléem a profondément marqué mon imaginaire, sans jamais le quitter.La poésie et la beauté de la nuit étoilée, la proximité tendre et curieuse des animaux, la présence aimante et protectrice de Joseph et de Marie, tout cela m'a profondément attaché à la présence de l'enfant Jésus.Si, bien plus tard, j'ai traversé des années de désert spirituel, une voix ne s'est jamais éteinte en moi. Je savais qu'un jour où l'autre, Jésus reviendrait dans ma vie, sans savoir ni où ni comment.Depuis, il y a eu la création de Zeteo. Et l'occasion pour moi de cheminer maintenant avec Jésus, et de découvrir que ce nouveau-né allait, à l'âge adulte, appeler l'humanité à le suivre. De jour en jour, j'entre un peu plus dans la lumière de la présence du Christ qui éclaire tous les mystères et qui chasse toutes les ombres.La méditation de Noël offerte si gracieusement par Frédérique Lemarchand me fait aussi penser à ses peintures. Le visage du Christ y est présent, dans sa lumière souvent, et parfois aussi dans cette beauté plus mystérieuse qui convient mieux à nos cœurs embrumés, et que le talent d'une artiste comme Frédérique sait si bien recréer.Les inquiétudes et les ombres du monde ne doivent pas nous faire oublier l'essentiel. Déjà, nous arrivons au moment du solstice où la lumière bascule et commence à l'emporter sur les ténèbres.N'oublions pas l'essentiel.N'oublions pas la merveille de Noël.N'oublions pas les merveilles du monde, les beautés du Vivant. S'il y a des choses que nous ne comprenons pas, sachons que le mystère est la porte d'entrée vers la beauté et l'amour. Comme dans l'infini des galaxies et la beauté renversante des étoiles, des planètes et de la vertigineuse dynamique cosmique. Comme dans une icône. Comme dans un tableau de Frédérique Lemarchand.Le Christ vient pour chacun d'entre nous. S'il se révèle toujours différemment, avec un message particulier pour chacun, il est l'incarnation de l'amour et de la vie éternelle.Nous sommes déjà entrés dans nos vies éternelles.Je souhaite que ce Noël révèlera à chacun la merveille de la présence divine en lui.J'exprime toute ma joie et ma gratitude personnelle pour le cadeau que Frédérique a offert à Zeteo. Pour tous les invités précédents de ce podcast, et ceux qui sont à venir avec des épisodes magnifiques. Pour les auditeurs, notamment ceux qui envoient des messages. Pour les donateurs, ceux qui ont fait un don déjà, comme ceux qui vont en faire un, aujourd'hui ou demain.J'aimerais que vous puissiez goûter la même joie que celle qui m'anime lorsque j'exprime ma gratitude envers vous !Joyeux Noël à tous, particulièrement encore à ceux qui souffrent, qui sont seuls, qui sont malades, qui ont peur, qui sont en colère, qui saignent dans leur coeur et dans leur corps, pour qu'eux aussi accueillent la merveille.Guillaume DevoudPour soutenir l'effort de Zeteo, podcast sans publicité et d'accès entièrement gratuit, vous pouvez faire un don. Il suffit pour cela de cliquer sur l'un des deux boutons ci-dessous, pour le paiement de dons en ligne au profit de l'association Telio qui gère Zeteo.Cliquer ici pour aller sur notre compte de paiement de dons en ligne sécurisé par HelloAsso.Ou cliquer ici pour aller sur notre compte Paypal.Vos dons sont défiscalisables à hauteur de 66% : par exemple, un don de 50€ ne coûte en réalité que 17€. Le reçu fiscal est généré automatiquement et immédiatement à tous ceux qui passent par la plateforme de paiement sécurisé en ligne de HelloAssoNous délivrons directement un reçu fiscal à tous ceux qui effectuent un paiement autrement (Paypal, chèque à l'association Telio, 76 rue de la Pompe, 75016 Paris – virement : nous écrire à info@zeteo.fr ).  Pour lire d'autres messages de nos auditeurs : cliquer ici.Pour en savoir plus au sujet de Zeteo, cliquer ici.Pour lire les messages de nos auditeurs, cliquer ici.Nous contacter : contact@zeteo.frProposer votre témoignage ou celui d'un proche : temoignage@zeteo.fr

Amala Klep Kremmel est une jeune femme au parcours de vie déjà riche. En quête de sens depuis son enfance, attirée à la fois par l'art, en particulier le théâtre, et la spiritualité, son cheminement l'a d'abord conduite à la découverte de la sagesse orientale.Elle a développé une pratique de la méditation et du yoga qui l'ont conduite à animer des cercles de formation, d'enseignement et de prière, en France et en Belgique. Dans ses livres, explorant mythes et récits, elle a partagé une vision forte et originale de la souveraineté de la femme.« J'avais beaucoup prié pour recevoir une foi inébranlable, je l'ai reçue » : Les épreuves qu'Amala a traversées, avec des moments où, comme elle le dit-elle-même, elle avait le sentiment d'avoir tout perdu, ont ouvert un nouveau chemin. Celui de la rencontre avec le Christ.Depuis, en s'appuyant sur une vaste lecture de la Bible, des Pères de l'Église, des grands mystiques de la tradition chrétienne, comme d'auteurs contemporains, dont Annick de Souzenelle, Jean-Yves Le Loup et Denis Marquet, Amala Klep Kremmel creuse un sillon large et profond.Large, avec les initiatives d'une jeune mère de deux enfants, pour qui la spiritualité doit être accessible et simple, où le corps, le cœur et l'âme participent : Des cercles de partage, de prière et de louange, nourris par la Parole divine lue dans l'Ancien et le Nouveau Testament, et ouvertes aux autres spiritualités.Large aussi avec les créations et les sessions théâtrales d'une actrice et metteuse en scène, pour des expériences individuelles et collectives en quête de connexion entre la spiritualité, la psychologie et les émotions.Profond, avec les livres d'une autrice féconde, qui a déjà écrit sur les rêves et leur signification, sur le chant comme médecine de l'âme, ou sur le féminin sacré.  Profond aussi, avec les créations artistiques d'une artiste pénétrée par la beauté de la lumière, qu'elle exprime par ses icônes et ses vitraux.  Depuis son enfance, Amala dit avoir toujours aimé rassembler les citations, parce qu'elles « ouvrent un chemin qui va directement de la tête au cœur ». D'où l'idée d'un coffret qu'elle a créé et qu'elle publie cette année, et qui contient plus d'une centaine de citations, essentiellement celles du Christ : L'Oracle de la Lumière Christique, qu'elle commente longuement au cours de cet épisode.Avec ces citations, Amala propose un autre accès aux lectures quotidiennes de l'Évangile, une pratique originale de la lectio divina enrichie, pour chaque citation, par une méditation et un rituel.Avec Amala, nous continuons la redécouverte d'un Christianisme de feu, si bien engagée dans les précédents épisodes de Zeteo. Nous allons à la rencontre d'une femme à la sagesse aussi étonnante qu'inspirante.Pour découvrir L'Oracle de la lumière Christique, le coffret créé par Amala Klep Kremmel, cliquer ici.Pour découvrir La Voie de la Grâce, le site d'Amala Klep Kremmel, cliquer iciLA PAROLE ET LE CERCLEChers amis, chers auditeurs de Zeteo,J'ai beaucoup de choses à vous dire, mais je vais tenter de faire au plus court.J'avais prévu, comme chaque année à la même période, un appel aux dons, dans une campagne un peu pensée, réfléchie, au mieux de mes capacités.Et puis tout est bousculé.Ces derniers mois, particulièrement depuis certains épisodes de l'été dernier, les choses changent autour de Zeteo. Elles ont pris plus de profondeur, d'intensité, il y a plus de partages aussi.Elles changent aussi pour le monde, mais pas dans le même sens.Parce que je sentais que les choses changeaient, j'ai cessé de faire des appels aux dons pendant plusieurs mois. Et pendant ce temps, les dons ont continué d'arriver, il y en a même eu un peu plus que les autres années aux mêmes périodesJ'ai vécu une suite de rencontres bouleversantes, et j'ai bien senti que vous étiez de plus en plus nombreux à être bouleversés vous aussi par ces rencontres.Parce que le monde change, qu'il donne les signes qu'il ne va pas dans le bon sens, un monde qui est tenté par le néant et qui semble aspiré par l'ombre… Il y a la double nécessité de l'urgence et de la beauté à accueillir et à relayer ceux qui portent le réel et la lumière.Il y a les témoignages tellement bouleversants sur Zeteo, je pourrais tous les citer.Pour n'en prendre que quelques uns, je pense à Denis Marquet, qui nous a rappelé que le Christianisme ne prend vie qu'au contact de l'autre, des autres, avec les autres, pour les autres.Il y a le message d'une des grandes invitées régulières de Zeteo, qui, parce qu'elle est une femme aussi humble que lumineuse, ne souhaite pas trop que je parle d'elle et donc que je ne nommerai pas. Elle dit qu'ensemble autour de ce podcast, nous formons justement un groupe, une communauté, celle des chevaliers de l'invisible. Avant elle, je n'avais pas réellement pris conscience de cette communauté.Il y a la rencontre avec Amala, et pour qui je n'ai pas hésité à bousculer le programme pour une diffusion dès aujourd'hui, à quelques jours de Noël. Quand vous aurez écouté cet épisode, je crois que vous serez nombreux à comprendre pourquoi c'était bien comme ça.Amala a un don particulier de rassembler toutes les paroles, les citations de la Bible, de Jésus, des grands mystiques chrétiens et pas que chrétiens. Elle a un autre don, celui d'une sagesse intérieure d'une profondeur et d'une richesse que j'ai rarement rencontrées. Et elle a encore d'autres dons, dont celui de créer des cercles, des communautés qui se rassemblent, qui découvrent et écoutent ensemble la parole biblique, qui prient, qui chantent le plus beau des chants, celui de la louange.Il y aura la semaine prochaine, juste avant Noël, la rencontre avec une femme à qui Zeteo doit tant… J'ose le dire, sans révéler encore son nom, un peu par coquetterie ou par goût du mystère, elle est avec Annick de Souzenelle, dont elle était tellement proche, la personne à qui Zeteo doit tellement. Cela sera un grand moment.La semaine dernière, Linda Bortoletto nous parlait du cercle, celui de la femme sacrée, et du glaive, celui de l'archange. Au moment de ce message, je vois un rapprochement de plus, celui du glaive, comme la parole, et du cercle, comme le silence et l'accueil.Le cercle, celui de nos communautés, et la parole, comme les citations d'Amala, la parole du Christ, celles de la Bible, comme vos messages, qui disent mieux que tout discours ce que ce podcast peut apporter de bien. Ces messages, vous pouvez les lire en cliquant sur le lien indiqué en bas de ce texte, à la rubrique « nos auditeurs » du site web de ce podcast. Ils sont très nombreux, et j'ai pu y ajouter beaucoup de ceux qui ont été reçus au cours de ces derniers jours.La parole, c'est aussi celle de Servanne.Servanne m'a envoyé cette semaine le message le plus poignant. Je voudrais vous inviter à nous unir en pensée et en prière pour elle, pour l'épreuve qu'elle traverse, pour qu'elle ne se sente pas seule, pour qu'elle soit rejointe par ce cercle qui nous relie, et par beaucoup d'autres cercles. Pour l'opération prochaine, pour la guérison de la maladie de Servanne, comme de tous ceux qui nous sont proches, pour tous ceux qui souffrent, qui sont seuls, qui sont dans le deuil, l'angoisse ou le désespoir.La guérison et la lumière viendront pour eux.Beaucoup de choses changent. Ce qui change pour Zeteo, c'est cette belle avancée vers la lumière divine que nous effectuons tous ensemble, dans la liberté belle et fragile de ce podcast. Et cela, malgré les temps inquiétants que nous vivons et les ombres qui menacent de recouvrir la Terre. La lumière finira par l'emporter, au creux le plus profond de l'ombre, des souffrances, des peurs et des doutes.Je reprends ici une citation que me confiait Amala pas plus tard qu'hier, elle qui en connaît des milliers, dont celle-ci de Marie Elia : « L'ombre a été tant aimée qu'elle en est devenue lumière. »Aimer nos ombres, c'est aimer la part de soi-même que l'on aime pas, dont on a peur, c'est aimer l'autre, c'est jusqu'à aimer l'ennemi, c'est suivre le Christ.J'avais beaucoup d'autres choses encore à vous dire que je vous dirai une autre fois.Et puisqu'à l'origine, ce message devait être un appel aux dons, je l'achève avec l'espoir et la confiance que si Zeteo est aligné sur la bienveillance universelle et divine, alors cette bienveillance saura susciter des donateurs parmi vous. Cette dernière quinzaine de l'année est le moment le plus décisif, pour que nous puissions continuer la mission d'un podcast à l'accès entièrement gratuit et qui est ouvert à tous.Je tiens ici à exprimer toute ma gratitude à ceux qui ont déjà fait un don, et à ceux qui vont le faire.Belle montée vers la lumière de Noël à tous, et ne l'oubliez pas,L'ombre a été tant aimée qu'elle en est devenue lumière.Guillaume DevoudPour soutenir l'effort de Zeteo, podcast sans publicité et d'accès entièrement gratuit, vous pouvez faire un don. Il suffit pour cela de cliquer sur l'un des deux boutons ci-dessous, pour le paiement de dons en ligne au profit de l'association Telio qui gère Zeteo.Cliquer ici pour aller sur notre compte de paiement de dons en ligne sécurisé par HelloAsso.Ou cliquer ici pour aller sur notre compte Paypal.Vos dons sont défiscalisables à hauteur de 66% : par exemple, un don de 50€ ne coûte en réalité que 17€. Le reçu fiscal est généré automatiquement et immédiatement à tous ceux qui passent par la plateforme de paiement sécurisé en ligne de HelloAssoNous délivrons directement un reçu fiscal à tous ceux qui effectuent un paiement autrement (Paypal, chèque à l'association Telio, 76 rue de la Pompe, 75016 Paris – virement : nous écrire à info@zeteo.fr ).  Pour lire d'autres messages de nos auditeurs : cliquer ici.Pour en savoir plus au sujet de Zeteo, cliquer ici.Pour lire les messages de nos auditeurs, cliquer ici.Nous contacter : contact@zeteo.frProposer votre témoignage ou celui d'un proche : temoignage@zeteo.fr

Linda Bortoletto, lorsqu'elle s'est égarée au cours d'une marche dans les Calanques de Cassis, ne se doutait pas qu'elle s'engageait dans une nouvelle aventure. Quand ses pas l'ont menée jusqu'à ce petit oratoire marial, elle a dit y avoir reçu un appel aussi original qu'inattendu : Celui d'aller parcourir toute l'Italie à pied, pour en raconter la Grande Belleza, la grande beauté.Linda Bortoletto, lorsqu'elle s'est engagée sur le Sentiero Italia, la marche la plus longue d'Italie, ne se doutait pas non plus qu'elle allait gravir, une à une, les barres d'une échelle céleste qui a transformé sa vie. Dès ses premiers pas, qui l'ont menée jusqu'à la plus grande crèche vivante d'Italie, elle dit à quel point le rayonnement de Marie l'a de nouveau bouleversée.Un peu plus loin, pas loin des pentes de l'Etna, sur la puissante terre sicilienne où « beauté et destruction dansent ensemble », Linda Bortoletto a découvert le sanctuaire d'une Vierge Noire. C'est à ce moment, dit-elle, que son voyage a réellement commencé.En découvrant, tout au long de sa remontée de l'Italie, la présence de nombreuses Madones noires qui suivent un mystérieux chemin stellaire, Linda dit avoir reçu un nouveau message de l'une d'entre elles : « Tu dois raconter qui je suis ».Alors qu'elle est partie habiter en Inde, peu après sa dernière participation à Zeteo, Linda est venue en France présenter son nouveau livre Italia Cosmica.Avec elle, nous sommes invités à entreprendre un parcours initiatique mystérieux et merveilleux, où les étoiles, les anges et des forêts de symboles nous guident et nous accompagnent.En révélant l'histoire des Madones Noires, qui remontent bien avant l'arrivée du Christianisme, Linda Bortoletto rétablit l'alliance avec les temps anciens et notre époque. En témoignant de la beauté, de la puissance et de la fécondité de Marie de Nazareth, magnifiée par les Madones, elle confirme à quel point la mère du Christ, et le Christ lui-même, ont été attendus et annoncés longtemps avant leur venue sur Terre.Linda nous le confie : « Longtemps, j'ai cru que le Christianisme ne portait plus de feu, qu'il avait bradé le mystère contre le dogme ». Le nouveau souffle si puissant qui l'anime aujourd'hui rallume toutes les braises de ce feu.Cet épisode est un hymne magnifique à Marie, aux femmes, au Christ et à l'incarnation. Linda, pétrie de sagesse orientale, infatigable marcheuse devant l'éternel, nous rappelle avec flamme que notre humanité, quand elle atteint l'union profonde, harmonieuse et du corps et de l'esprit, devient divine.Pour lire Italia Cosmica, le nouveau livre de Linda Bortoletto, cliquer ici.LA GRANDE BEAUTÉChers amis, chers auditeurs de Zeteo,En préparant l'épisode diffusé dès aujourd'hui, je ne m'attendais pas, pour cette troisième participation de Linda Bortoletto à Zeteo, à vivre un tel bouleversement. Certes, après l'avoir déjà rencontrée deux fois, j'avais compris qu'il y avait, chez cette fine et jolie jeune femme, la profondeur, le talent, l'énergie et le courage qu'avaient si bien exprimé ses premiers livres.Depuis, j'ai compris pourquoi Italia Cosmica est un livre si important pour elle. Pour venir le présenter, elle a quitté pour quelques semaines l'Inde, sa nouvelle terre d'accueil. Et elle apporte ici, avec elle et en elle, cette mystérieuse et attirante alliance entre l'Orient de sa mère, et l'Occident de son père.Des alliances, avec Linda, il y en a d'autres ici. D'où le bouleversement qu'elle a vécu, dans sa rencontre avec les Vierges Noires d'Italie, qu'elle nous fait vivre à notre tour.Alliances et réconciliations.Entre les sagesses anciennes qui, depuis si longtemps, avaient attendu et annoncé la venue du Christ et le rôle de la femme qui allait l'enfanter, et nos sagesses actuelles qui ont tellement besoin de revenir à La Source.Entre Marie et toutes les femmes. Les Madones Noires, comme ose le dire une amie de Linda, représentent toutes les déesses. Autour de Marie de Nazareth, elles exaltent le féminin sacré et rassemblent toutes les femmes.Telle est la grande beauté que révèle cet épisode. Elle ne se limite pas à la merveilleuse et unique Italie, chantée par Linda Bortoletto. C'est une beauté qui exalte la création, la nature, l'art et les œuvres humaines. C'est aussi, comme le dit encore Linda avec audace, la beauté de l'incarnation et de l'union du corps et de l'esprit, dans toute la dimension sacrée de l'amour humain.La grande beauté, c'est celle de Marie de Nazareth, restituée ici dans toute sa puissance. C'est pourquoi cet épisode est une si belle marche à gravir dans notre montée vers Noël.La grande beauté, enfin, est dans la gratitude.Pour Linda, comme pour tous les invités venus et à venir sur Zeteo. Et pour vous, chers auditeurs, pour votre fidélité, votre enthousiasme et votre émotion souvent, votre soutien nécessaire et votre générosité aussi.Sans vous, et sans vos dons, ceux qui sont venus et ceux qui, en espérance, sont à venir, il n'y aurait pas cette contribution à la beauté du monde qu'ensemble, nous élevons chaque semaine.« Par-dessus tout, veille sur ton cœur, c'est de lui que jaillit la vie. » (Pr 4,23)Tous ensemble vers Noël,Guillaume DevoudPour soutenir l'effort de Zeteo, podcast sans publicité et d'accès entièrement gratuit, vous pouvez faire un don. Il suffit pour cela de cliquer sur l'un des deux boutons ci-dessous, pour le paiement de dons en ligne au profit de l'association Telio qui gère Zeteo.Cliquer ici pour aller sur notre compte de paiement de dons en ligne sécurisé par HelloAsso.Ou cliquer ici pour aller sur notre compte Paypal.Vos dons sont défiscalisables à hauteur de 66% : par exemple, un don de 50€ ne coûte en réalité que 17€. Le reçu fiscal est généré automatiquement et immédiatement à tous ceux qui passent par la plateforme de paiement sécurisé en ligne de HelloAssoNous délivrons directement un reçu fiscal à tous ceux qui effectuent un paiement autrement (Paypal, chèque à l'association Telio, 76 rue de la Pompe, 75016 Paris – virement : nous écrire à info@zeteo.fr ).  Pour lire d'autres messages de nos auditeurs : cliquer ici.Pour en savoir plus au sujet de Zeteo, cliquer ici.Pour lire les messages de nos auditeurs, cliquer ici.Nous contacter : contact@zeteo.frProposer votre témoignage ou celui d'un proche : temoignage@zeteo.fr

En Chine, Emmanuel Macron est arrivé à Pékin et a été accueilli en grande pompe. Deux grands sujets ont été évoqués autour de la table, notamment au sujet des déséquilibres commerciaux croissants entre la Chine et l'Europe. Écoutez RTL autour du monde du 4 décembre 2025.Hébergé par Audiomeans. Visitez audiomeans.fr/politique-de-confidentialite pour plus d'informations.

À l'occasion de la journée internationale des personnes handicapées, nous parlons de leur santé mentale. Il s'agit non seulement de favoriser le bien-être des personnes en situation de handicap, mais également de mieux diagnostiquer et prendre en charge certaines comorbidités psychiques. Les affections mentales constituent en effet une comorbidité fréquente et parfois négligée, tant pour les personnes affectées dans leur mobilité par un handicap physique que pour les personnes concernées par un trouble moteur.  La santé mentale, grande cause nationale en France pour 2025, est reconduite pour l'année 2026. Les obstacles à la santé mentale sont multiples : qu'il s'agisse de l'accès aux soignants formés et spécialisés, les freins d'ordre financiers, géographiques, auxquels s'ajoutent les préjugés ou les fake-news, qui exposent les personnes à des retards de prise en charge ou à des traitements inappropriés. Les entraves et inégalités dans cet accès aux soins psychologiques et psychiatriques sont encore plus présentes pour certaines populations vulnérables. Aujourd'hui, à l'occasion de la journée internationale des personnes handicapées, Priorité Santé évoque les besoins et obstacles spécifiques qui concernent leur santé mentale, qu'ils ou elles soient porteur.es d'un handicap physique ou moteur.  Le double fardeau du handicap et de la santé mentale  Pour les personnes en situation de handicap, la détresse psychologique peut être générée par des émotions associées au handicap lui-même : angoisse d'être stigmatisé, isolé, exclu tout comme la difficulté de le dire. Des facteurs spécifiques peuvent également intervenir, comme la gestion de la douleur, la détresse affective et sexuelle, la frustration associée au manque d'autonomie.   À côté des problématiques liées directement ou handicap, peuvent se développer également des comorbidités d'ordre psychique et/ou psychiatrique ; avec un risque de sous-diagnostic, et donc d'absence de prise en charge, susceptible d'amplifier les symptômes et d'accroître le fardeau de la maladie et d'amplifier leur sévérité.  Valoriser la différence et les compétences   L'enjeu de la santé mentale dans le parcours de soins des personnes en situation de handicap doit donc être valorisé et considéré en fonction des spécificités des parcours de chacune et de chacun, des émotions individuelles, mais aussi des compétences propres aux personnes en situation de handicap. Mieux comprendre, mieux prendre en charge, lutter contre la stigmatisation, pour rendre le soin réellement accessible à tous les publics.  Avec : Matteo Bussoletti, psychologue, psychothérapeute, exerce au sein d'un IEM (Institut d'Éducation Motrice) dans la région du Havre, accueillant des enfants et des adolescents avec une déficience motrice et des troubles associés. Il est l'auteur de plusieurs articles sur des problématiques émotionnelles, scolaires et développementales de l'enfant et de l'adolescent. Ses travaux portent également sur les pratiques d'accompagnement psychologique, notamment l'hypnose, qu'il a intégrée à la prise en charge des jeunes en situation de handicap Hortense Aka Dago-Akribi, psychologue clinicienne et professeure titulaire à l'Université Félix Houphouët Boigny de Cocody à Abidjan en Côte d'Ivoire.   Un reportage de Charlie Dupiot. ► En fin d'émission, nous parlons du Téléthon qui se tient les 5 et 6 décembre 2025 en France. À quelques jours de ce rendez-vous dédié à la recherche contre les maladies génétiques, coup de projecteur sur le projet européen DREAMS, un projet pour améliorer la prise en charge de cinq maladies rares : la myopathie de Duchenne, une myopathie centronucléaire, la myopathie d'Emery-Dreifuss, la maladie de Pompe et la maladie de Danon. Interview de Xavier Nissan, directeur de recherche à I-Stem et coordonnateur du projet Dreams.   Programmation musicale : ► Nathi feat. Kayla Carrington – A vida é minha ► Natanjo – Kimia.

À l'occasion de la journée internationale des personnes handicapées, nous parlons de leur santé mentale. Il s'agit non seulement de favoriser le bien-être des personnes en situation de handicap, mais également de mieux diagnostiquer et prendre en charge certaines comorbidités psychiques. Les affections mentales constituent en effet une comorbidité fréquente et parfois négligée, tant pour les personnes affectées dans leur mobilité par un handicap physique que pour les personnes concernées par un trouble moteur.  La santé mentale, grande cause nationale en France pour 2025, est reconduite pour l'année 2026. Les obstacles à la santé mentale sont multiples : qu'il s'agisse de l'accès aux soignants formés et spécialisés, les freins d'ordre financiers, géographiques, auxquels s'ajoutent les préjugés ou les fake-news, qui exposent les personnes à des retards de prise en charge ou à des traitements inappropriés. Les entraves et inégalités dans cet accès aux soins psychologiques et psychiatriques sont encore plus présentes pour certaines populations vulnérables. Aujourd'hui, à l'occasion de la journée internationale des personnes handicapées, Priorité Santé évoque les besoins et obstacles spécifiques qui concernent leur santé mentale, qu'ils ou elles soient porteur.es d'un handicap physique ou moteur.  Le double fardeau du handicap et de la santé mentale  Pour les personnes en situation de handicap, la détresse psychologique peut être générée par des émotions associées au handicap lui-même : angoisse d'être stigmatisé, isolé, exclu tout comme la difficulté de le dire. Des facteurs spécifiques peuvent également intervenir, comme la gestion de la douleur, la détresse affective et sexuelle, la frustration associée au manque d'autonomie.   À côté des problématiques liées directement ou handicap, peuvent se développer également des comorbidités d'ordre psychique et/ou psychiatrique ; avec un risque de sous-diagnostic, et donc d'absence de prise en charge, susceptible d'amplifier les symptômes et d'accroître le fardeau de la maladie et d'amplifier leur sévérité.  Valoriser la différence et les compétences   L'enjeu de la santé mentale dans le parcours de soins des personnes en situation de handicap doit donc être valorisé et considéré en fonction des spécificités des parcours de chacune et de chacun, des émotions individuelles, mais aussi des compétences propres aux personnes en situation de handicap. Mieux comprendre, mieux prendre en charge, lutter contre la stigmatisation, pour rendre le soin réellement accessible à tous les publics.  Avec : Matteo Bussoletti, psychologue, psychothérapeute, exerce au sein d'un IEM (Institut d'Éducation Motrice) dans la région du Havre, accueillant des enfants et des adolescents avec une déficience motrice et des troubles associés. Il est l'auteur de plusieurs articles sur des problématiques émotionnelles, scolaires et développementales de l'enfant et de l'adolescent. Ses travaux portent également sur les pratiques d'accompagnement psychologique, notamment l'hypnose, qu'il a intégrée à la prise en charge des jeunes en situation de handicap Hortense Aka Dago-Akribi, psychologue clinicienne et professeure titulaire à l'Université Félix Houphouët Boigny de Cocody à Abidjan en Côte d'Ivoire.   Un reportage de Charlie Dupiot. ► En fin d'émission, nous parlons du Téléthon qui se tient les 5 et 6 décembre 2025 en France. À quelques jours de ce rendez-vous dédié à la recherche contre les maladies génétiques, coup de projecteur sur le projet européen DREAMS, un projet pour améliorer la prise en charge de cinq maladies rares : la myopathie de Duchenne, une myopathie centronucléaire, la myopathie d'Emery-Dreifuss, la maladie de Pompe et la maladie de Danon. Interview de Xavier Nissan, directeur de recherche à I-Stem et coordonnateur du projet Dreams.   Programmation musicale : ► Nathi feat. Kayla Carrington – A vida é minha ► Natanjo – Kimia.

Marc Bezançon est un homme habité par une foi vivante et un sens de l'engagement profond. Après de brillantes études, il a exercé des fonctions d'abord au service de l'État, au cours des négociations visant à l'harmonisation européenne des services bancaires. Il a ensuite intégré une des plus grandes banques françaises, au sein de laquelle il a développé les services d'assurance.Marc Bezançon témoigne d'une « recherche désespérée d'amour », engagée dès les premières heures de sa vie, avec son frère jumeau, en raison de la grave maladie de sa mère dont il a été trop longuement séparé.  Marc Bezançon révèle comment la rencontre avec Jésus a bouleversé sa vie. Il revient sur les étapes marquantes de sa vie spirituelle abondée par une relation directe avec le divin. Il raconte les effusions de l'esprit, les visions, les locutions reçues aux moments charnières de sa vie, et qui continuent de l'accompagner aujourd'hui.Les grâces reçues par Marc Bezançon sont à la hauteur des épreuves rencontrées. La longue maladie de son épouse, la sienne, les décès autour de lui, ont creusé un puits de souffrance à chaque fois rempli par la lumière, la consolation et l'amour divin.Ces grâces lui permettent aujourd'hui de continuer d'avancer sur le chemin de l'entraide aux plus démunis à laquelle il consacre maintenant sa vie, au service du mouvement international Fondacio pour qui il recherche les fonds.Dans ce cœur à cœur vibrant avec Marc Bezançon, nous recevons de belles lueurs de la douce et réconfortante lumière divine. Nous sommes entraînés, comme lui, à ouvrir toujours plus grande notre confiance dans la bienveillance divine qui est partout. Nous sommes invités à lui demander, comme Marc le fait lui-même, les grâces dont nous avons besoin. Et à nous disposer à accueillir tout ce qui vient, avec l'esprit en paix et le cœur en joie.Pour découvrir Fondacio, cliquer ici.GRATITUDE ET DÉPASSEMENTChers amis, chers auditeurs de Zeteo,C'est un message de gratitude que j'aimerais partager avec tous ceux qui composent cette aventure qui nous permet de nous retrouver chaque semaine : les invités, les auditeurs, les donateurs.J'ai le profond sentiment que cette 6ème année depuis la création de Zeteo s'achève différemment.Il y a d'un côté la situation inquiétante du monde qu'on ne peut ignorer ou nier. Il y a aussi des grâces particulières pour notre temps. Comme le dira une prochaine invitée au moment de Noël, il y a une lumière qui vient pour chasser toutes les ombres, même les plus tenaces.Je suis ému en voyant la croissance de l'audience, plus dynamique encore cette année que les précédentes. Je suis bouleversé par les messages, les témoignages d'auditeurs que je reçois, et j'espère avoir le temps de pouvoir partager sur le site de Zeteo les plus récents dans les jours qui viennent.Je suis aussi touché par la générosité de certains d'entre vous. En fait, cela fait maintenant plus de 4 mois que j'ai cessé de faire des appels aux dons, et depuis, Zeteo a continué d'en recevoir, même un peu plus que l'année passée à la même période.Pour tout cela, pour tous les épisodes si beaux diffusés cette année, pour la communion partagée tous ensemble, pour la générosité de ceux qui ont fait un don, je tiens à dire à la fois toute ma gratitude et ce si agréable sentiment de dépassement.Gratitude et dépassement face à la bienveillance divine infinie, universelle, exprimée dans tout le vivant, c'est d'elle que nous recevons tout, le souffle, la vie, la lumière, l'amour, l'entraide.En ce moment, il y a lutte entre les ténèbres et la lumière, mais je n'ai aucun doute que c'est la lumière qui va l'emporter. Elle l'a déjà emporté, et je le mesure aussi à la joie, la légèreté, la vibration d'amour qui nous relie tous et qui me porte au quotidien, et je le mesure aussi en pensant à tous les épisodes à venir d'ici la fin de cette année. Ils sont désormais tous enregistrés, et je suis impatient de les diffuser tous.Je pense à cet épisode magnifique, celui d'aujourd'hui avec Marc Bezançon. Marc, dont la vie actuelle est consacrée à récolter des fonds pour aider les plus démunis, nous parle d'abandon et d'abondance.Alors je finirai ce message avec cette double espérance. Celle que l'abandon, c'est-à-dire la confiance, soit toujours de plus en plus grande, et celle de l'abondance pour vous, et aussi pour Zeteo.L'abondance, c'est la manne qui est juste. Ni trop, ni trop peu.Pour nous, cette période qui commence est la plus importante de l'année pour nos récoltes de dons. Elle détermine beaucoup la suite d'une aventure qui est à la fois belle pour tout ce que je viens d'écrire, et fragile, parce qu'elle est indépendante, donc libre, et qu'elle repose sur l'entière gratuité d'accès à Zeteo. Elle n'a aucune autre sources de revenus que vos dons.Alors d'avance, un grand merci à ceux qui, en cette fin d'année, feront un geste pour soutenir l'effort de Zeteo,à bientôt,et à tous, particulièrement ceux qui souffrent et qui sont seuls,belle montée vers Noël.Guillaume DevoudPour soutenir l'effort de Zeteo, podcast sans publicité et d'accès entièrement gratuit, vous pouvez faire un don. Il suffit pour cela de cliquer sur l'un des deux boutons ci-dessous, pour le paiement de dons en ligne au profit de l'association Telio qui gère Zeteo.Cliquer ici pour aller sur notre compte de paiement de dons en ligne sécurisé par HelloAsso.Ou cliquer ici pour aller sur notre compte Paypal.Vos dons sont défiscalisables à hauteur de 66% : par exemple, un don de 50€ ne coûte en réalité que 17€. Le reçu fiscal est généré automatiquement et immédiatement à tous ceux qui passent par la plateforme de paiement sécurisé en ligne de HelloAssoNous délivrons directement un reçu fiscal à tous ceux qui effectuent un paiement autrement (Paypal, chèque à l'association Telio, 76 rue de la Pompe, 75016 Paris – virement : nous écrire à info@zeteo.fr ).  Pour lire d'autres messages de nos auditeurs : cliquer ici.Pour en savoir plus au sujet de Zeteo, cliquer ici.Pour lire les messages de nos auditeurs, cliquer ici.Nous contacter : contact@zeteo.frProposer votre témoignage ou celui d'un proche : temoignage@zeteo.fr

Hubert de Boisredon est un entrepreneur engagé qui, dès le début de sa brillante carrière professionnelle, est resté fidèle aux appels du cœur et de la conscience.Aujourd'hui, dans un monde agité, dans une société occidentale tourmentée et gagnée par le doute et les peurs, il n'hésite pas à témoigner une fois de plus, en offrant un regard profondément humain, inspiré par sa foi chrétienne, sa vision d'une économie juste, d'une entreprise en quête de bien commun plutôt que d'opportunisme, et d'une société ouverte aux plus démunis.Habité par la passion de transmettre, et parce qu'il est persuadé que nous pouvons toujours faire le choix de diriger notre vie plutôt que de la subir, Hubert de Boisredon vient d'écrire un nouveau livre. Dans Le Courage des Chefs, il s'adresse à tous ceux qui cherchent à vivre autrement. Le chef, c'est celui qui sait faire émerger le meilleur de chacun, qui incarne une espérance, qui apprend à ne pas ignorer la peur mais plutôt à l'habiter sans s'y soumettre, et qui a le courage de tenir fidèlement aux décisions et aux engagements pris en conscience.Que ferai-je de mon courage ? La question que pose Hubert de Boisredon parle à chacun de nous. Nous avons tous une lumière en nous. Cette voix intérieure qui nous invite, particulièrement dans les moments importants et souvent difficiles, à agir pour le bien. Savons-nous y répondre ? L'exemple d'humanité, d'action et de bienveillance qu'il nous offre nous y encourage profondément. Pour lire Le Courage des Chefs, le nouveau livre d'Hubert de Boisredon, cliquer ici.VERS MA LUMIÈREChers amis, chers auditeurs de Zeteo,Chaque jour, nous voyons un peu plus les jours raccourcir, et nos ciels s'assombrir. D'ailleurs, ceux-ci sont porteurs, pour beaucoup d'entre nous déjà, des premières neiges de l'hiver.C'était mon cas cette semaine, lorsque j'ai essuyé une vraie tempête en Belgique. Il valait pourtant bien de la traverser, car j'ai pu en rapporter un bel épisode pour Noël.Cela n'est pas pour rien que les flocons de neige ressemblent à des étoiles. En fait, je crois qu'ils en sont les larmes…C'est ce que je me disais en les voyant virevolter et danser devant mon pare-brise. Cela me rassurait un peu, car la nuit avançait vite et j'avais encore plusieurs centaines de kilomètres à parcourir.Quelques heures plus tard, je me suis endormi en emportant dans mon sommeil le coton de mes belles étoiles blanches. Je me suis dit qu'elles m'avaient certainement aidé à regagner ma maison malgré la route devenue glissante et dangereuse.Il y a les jours froids et sombres, une actualité de plus en plus étrange et parfois inquiétante, mais il y a toujours la lumière. Celle des étoiles, qui nous parviennent même lorsque le ciel est lourd. Celle dont témoigne Hubert de Boisredon dans le nouvel épisode diffusé dès aujourd'hui.Le Royaume est aussi et avant tout à l'intérieur de nous. Et il y a toujours, en chacun, cette étincelle de lumière qui ne disparaît jamais. Et il y a toujours, en nous ou auprès de nous, un souffle suffisant pour la rallumer. C'est ce que m'inspire la magnifique question posée par Hubert de Boisredon, qui cite ici la poétesse Anna de Noailles : « Que ferai-je de mon courage ? »Cette question sonne juste. Elle entend déjà que le courage, nous l'avons toujours. Bien-sûr, elle peut sembler absurde pour ceux qui souffrent beaucoup et qui peuvent être accablés par le désespoir.La lumière existe. Elle vient, avec la promesse de Noël qui approche. Et quand il est vraiment difficile d'y croire, alors il suffit parfois d'un geste simple. Celui d'accueillir l'immédiat. Alors, les surprises ne manquent pas…L'étincelle viendra de l'intérieur, ou de l'extérieur. Je suis émerveillé par mes rencontres actuelles pour Zeteo. Elles manifestent à quel point la lumière existe et circule, animée dans de plus en plus de cercles et de lieux où des communautés se créent et se retrouvent.Et je suis également émerveillé, et dépassé, de prendre conscience que ce podcast, à sa manière, constitue aussi une communauté rassemblée autour de cette lumière.Notre puissance est immense,Très belle journée de dimanche, avec une pensée particulière pour ceux qui sont seuls et qui souffrent,Lumineusement,Guillaume DevoudPour soutenir l'effort de Zeteo, podcast sans publicité et d'accès entièrement gratuit, vous pouvez faire un don. Il suffit pour cela de cliquer sur l'un des deux boutons ci-dessous, pour le paiement de dons en ligne au profit de l'association Telio qui gère Zeteo.Cliquer ici pour aller sur notre compte de paiement de dons en ligne sécurisé par HelloAsso.Ou cliquer ici pour aller sur notre compte Paypal.Vos dons sont défiscalisables à hauteur de 66% : par exemple, un don de 50€ ne coûte en réalité que 17€. Le reçu fiscal est généré automatiquement et immédiatement à tous ceux qui passent par la plateforme de paiement sécurisé en ligne de HelloAssoNous délivrons directement un reçu fiscal à tous ceux qui effectuent un paiement autrement (Paypal, chèque à l'association Telio, 76 rue de la Pompe, 75016 Paris – virement : nous écrire à info@zeteo.fr ).  Pour lire d'autres messages de nos auditeurs : cliquer ici.Pour en savoir plus au sujet de Zeteo, cliquer ici.Pour lire les messages de nos auditeurs, cliquer ici.Nous contacter : contact@zeteo.frProposer votre témoignage ou celui d'un proche : temoignage@zeteo.fr

Ecoutez L'oeil d'Alex Vizorek du 21 novembre 2025.Hébergé par Audiomeans. Visitez audiomeans.fr/politique-de-confidentialite pour plus d'informations.

Ecoutez L'oeil d'Alex Vizorek du 21 novembre 2025.Hébergé par Audiomeans. Visitez audiomeans.fr/politique-de-confidentialite pour plus d'informations.

durée : 00:46:12 - Bienvenue chez vous : à la une - La pompe à chaleur séduit par ses promesses : chauffage économique, confort thermique et aides financières. Mais l'installation doit être rigoureusement adaptée au logement. Diagnostic, isolation, réglages : tout se joue en amont. Un spécialiste de l'ALEC fait le point. Vous aimez ce podcast ? Pour écouter tous les autres épisodes sans limite, rendez-vous sur Radio France.

Êtes-vous certain de maîtriser la langue française ? Règles de grammaire étonnantes, abus de langage, vocabulaire mal employé, origine insoupçonnée d'expressions... vous allez être surpris ! Hébergé par Acast. Visitez acast.com/privacy pour plus d'informations.

Horreur dans un bar du Plateau-Mont-Royal. Un bébé naissant abandonné devant la porte d’une résidence à Longueuil. Le procès d’un entrepreneur accusé d’agression sexuelle encore reporté. Faits divers avec Maxime Deland, journaliste à l’agence QMI. Regardez aussi cette discussion en vidéo via https://www.qub.ca/videos ou en vous abonnant à QUB télé : https://www.tvaplus.ca/qub ou sur la chaîne YouTube QUB https://www.youtube.com/@qub_radio Pour de l'information concernant l'utilisation de vos données personnelles - https://omnystudio.com/policies/listener/fr

On this episode, my guest is Stephen Jenkinson, culture activist and ceremonialist advocating a handmade life and eloquence. He is an author, a storyteller, a musician, sculptor and off-grid organic farmer. Stephen is the founder/ principal instructor of the Orphan Wisdom School in Canada, co-founded with his wife Nathalie Roy in 2010. Also a sought-after workshop leader, articulating matters of the heart, human suffering, confusions through ceremony.He is the author of several influential books, including Money and the Soul's Desires, Die Wise: A Manifesto for Sanity and Soul (2015), Come of Age: The Case for Elderhood in a Time of Trouble (2018), A Generation's Worth: Spirit Work While the Crisis Reigns (2021), and Reckoning (2022), co-written with Kimberly Ann Johnson. His most recent book, Matrimony: Ritual, Culture, and the Heart's Work, was released in August 2025. He is also involved in the musical project Nights of Grief & Mystery with singer-songwriter Gregory Hoskins, which has toured across North America, Europe, Australia, and New Zealand.Show Notes:* The Bone House of the Orphan Wisdom Enterprise* Matrimony: Ritual, Culture and the Heart's Work* The Wedding Industry* Romantic Sameness and Psychic Withering* The Two Tribes* The Roots of Hospitality* The Pompous Ending of Hospitality* Debt, And the Estrangement of the Stranger* More Than Human Hospitality* The Alchemy of the Orphan Wisdom SchoolHomework:Matrimony: Ritual, Culture, and the Heart's Work | PurchaseOrphan WisdomThe Scriptorium: Echoes of an Orphan WisdomTranscription:Chris: This is an interview that I've been wondering about for a long time in part, because Stephen was the first person I ever interviewed for the End of Tourism Podcast. In Oaxaca, Mexico, where I live Stephen and Natalie were visiting and were incredibly, incredibly generous. Stephen, in offering his voice as a way to raise up my questions to a level that deserve to be contended with.We spoke for about two and a half hours, if I remember correctly. And there was a lot in what you spoke to towards the second half of the interview that I think we're the first kind of iterations of the Matrimony book.We spoke a little bit about the stranger and trade, and it was kind of startling as someone trying to offer their first interview and suddenly hearing something [00:01:00] that I'd never heard before from Stephen. Right. And so it was quite impressive. And I'm grateful to be here now with y'all and to get to wonder about this a little more deeply with you Stephen.Stephen: Mm-hmm. Hmm.Chris: This is also a special occasion for the fact that for the first time in the history of the podcast, we have a live audience among us today. Strange doings. Some scholars and some stewards and caretakers of the Orphan Wisdom enterprise. So, thank you all as well for coming tonight and being willing to listen and put your ears to this.And so to begin, Stephen, I'm wondering if you'd be willing to let those who will be listening to this recording later on know where we're gathered in tonight?Stephen: Well, we're in... what's the name of this township?Nathalie: North Algona.Stephen: North Algona township on the borders, an eastern gate [00:02:00] of Algonquin Park. Strangely named place, given the fact that they were the first casualties of the park being established. And we're in a place that never should have been cleared - my farm. It should never have been cleared of the talls, the white pines that were here, but the admiralty was in need back in the day. And that's what happened there. And we're in a place that the Irish immigrants who came here after the famine called "Tramore," which more or less means "good-frigging luck farming."It doesn't technically mean that, but it absolutely means that. It actually means "sandy shore," which about covers the joint, and it's the only thing that covers the joint - would be sand. You have to import clay. Now, that's a joke in many farming places in the world, but if we wanted any clay, we'd have to bring it in and pay for the privilege.And the farm has been in [00:03:00] my, my responsibility for about 25 years now, pretty close to that. And the sheep, or those of them left because the coyotes have been around for the first time in their casualty-making way... They're just out here, I'm facing the field where they're milling around.And it's the very, very beginnings of the long cooling into cold, into frigid, which is our lot in this northern part of the hemisphere, even though it's still August, but it's clear that things have changed. And then, we're on a top of a little hill, which was the first place that I think that we may have convened a School here.It was a tipi, which is really worked very well considering we didn't live here, so we could put it up and put it down in the same weekend. [00:04:00] And right on this very hill, we were, in the early days, and we've replaced that tipi with another kind of wooden structure. A lot more wood in this one.This has been known as "The Teaching Hall" or "The Great Hall," or "The Hall" or "The Money Pit, as it was known for a little while, but it actually worked out pretty well. And it was I mean, people who've come from Scandinavia are knocked out by the kind of old-style, old-world visitation that the place seems to be to them.And I'd never really been before I had the idea what this should look like, but I just went from a kind of ancestral memory that was knocking about, which is a little different than your preferences, you know. You have different kinds of preferences you pass through stylistically through your life, but the ones that lay claim to you are the ones that are not interested in your [00:05:00] preferences. They're interested in your kind of inheritance and your lineage.So I'm more or less from the northern climes of Northern Europe, and so the place looks that way and I was lucky enough to still have my carving tools from the old days. And I've carved most of the beams and most of the posts that keep the place upright with a sort of sequence of beasts and dragons and ne'er-do-wells and very, very few humans, I think two, maybe, in the whole joint. Something like that. And then, mostly what festoons a deeply running human life is depicted here. And there's all kinds of stories, which I've never really sat down and spoken to at great length with anybody, but they're here.And I do deeply favour the idea that one day [00:06:00] somebody will stumble into this field, and I suppose, upon the remains of where we sit right now, and wonder "What the hell got into somebody?" That they made this mountain of timber moldering away, and that for a while what must have been, and when they finally find the footprint of, you know, its original dimensions and sort of do the wild math and what must have been going on in this sandy field, a million miles in away from its home.And wherever I am at that time, I'll be wondering the same thing.Audience: Hmm.Stephen: "What went on there?" Even though I was here for almost all of it. So, this was the home of the Orphan Wisdom School for more than a decade and still is the home of the Orphan Wisdom School, even if it's in advance, or in retreat [00:07:00] or in its doldrums. We'll see.And many things besides, we've had weddings in here, which is wherein I discovered "old-order matrimony," as I've come to call it, was having its way with me in the same way that the design of the place did. And it's also a grainery for our storage of corn. Keep it up off the ground and out of the hands of the varmints, you know, for a while.Well that's the beginning.Chris: Hmm. Hmm. Thank you Stephen.Stephen: Mm-hmm.Chris: You were mentioning the tipi where the school began. I remember sleeping in there the first time I came here. Never would I have thought for a million years that I'd be sitting here with you.Stephen: It's wild, isn't it?Chris: 12 years later.?: Yeah.Chris: And so next, I'd like to do my best in part over the course of the next perhaps hour or two to congratulate you on the release of [00:08:00] your new book, Matrimony: Ritual, Culture, and the Heart's Work.Stephen: Thank you.Chris: Mm-hmm. I'm grateful to say like many others that I've received a copy and have lent my eyes to your good words, and what is really an incredible achievement.For those who haven't had a chance to lay their eyes on it just yet, I'm wondering if you could let us in on why you wrote a book about matrimony in our time and where it stands a week out from its publication.Stephen: Well, maybe the answer begins with the question, "why did you write a book, having done so before?" And you would imagine that the stuff that goes into writing a book, you'd think that the author has hopes for some kind of redemptive, redeeming outcome, some kind of superlative that drops out the back end of the enterprise.And you know, this is [00:09:00] the seventh I've written. And I would have to say that's not really how it goes, and you don't really know what becomes of what you've written, even with the kind people who do respond, and the odd non-monetary prize that comes your way, which Die Wise gamed that.But I suppose, I wrote, at all partly to see what was there. You know, I had done these weddings and I was a little bit loathe to let go, to let the weddings turn entirely into something historical, something that was past, even though I probably sensed pretty clearly that I was at the end of my willingness to subject myself to the slings and arrows that came along with the enterprise, but it's a sweet sorrow, or there's a [00:10:00] wonder that goes along with the tangle of it all. And so, I wrote to find out what happened, as strange as that might sound to you. You can say, "well, you were there, you kind of knew what happened." But yes, I was witness to the thing, but there's the act of writing a book gives you the opportunity to sort of wonder in three-dimensions and well, the other thing I should say is I was naive and figured that the outfit who had published the, more or less prior two books to this one, would kind of inevitably be drawn to the fact that same guy. Basically, same voice, new articulation. And I was dumbfounded to find out that they weren't. And so, it's sort of smarted, you know?And I think what I did was I just set the whole [00:11:00] enterprise aside, partly to contend with the the depths of the disappointment in that regard, and also not wanting to get into the terrible fray of having to parse or paraphrase the book in some kind of elevator pitch-style to see if anybody else wanted to look at it. You know, such as my touchy sense of nobility sometimes, you know, that I just rather not be involved in the snarl of the marketplace any longer.So, I withdrew and I just set it aside but it wasn't that content to be set, set aside. And you know, to the book's credit, it bothered me every once in a while. It wasn't a book at the point where I was actually trying to engineer it, you know, and, and give it some kind of structure. I had piles of paper on the floor representing the allegation of chapters, trying to figure out what the relationship was [00:12:00] between any of these things.What conceivably should come before what. What the names of any of these things might be. Did they have an identity? Was I just imposing it? And all of that stuff I was going through at the same time as I was contending with a kind of reversal in fortune, personally. And so in part, it was a bit of a life raft to give me something to work on that I wouldn't have to research or dig around in the backyard for it and give me some sort of self-administered occupation for a while.Finally, I think there's a parallel with the Die Wise book, in that when it came to Die Wise, I came up with what I came up with largely because, in their absolute darkest, most unpromising hours, an awful lot of dying people, all of whom are dead now, [00:13:00] let me in on some sort of breach in the, the house of their lives.And I did feel that I had some obligation to them long-term, and that part of that obligation turned into writing Die Wise and touring and talking about that stuff for years and years, and making a real fuss as if I'd met them all, as if what happened is really true. Not just factually accurate, but deeply, abidingly, mandatorily true.So, although it may be the situation doesn't sound as extreme, but the truth is, when a number of younger - than me - people came to me and asked me to do their weddings, I, over the kind of medium-term thereafter, felt a not dissimilar obligation that the events that ensued from all of that not [00:14:00] be entrusted entirely to those relatively few people who attended. You know, you can call them "an audience," although I hope I changed that. Or you could call them "witnesses," which I hope I made them that.And see to it that there could be, not the authorized or official version of what happened, but to the view from here, so to speak, which is, as I sit where I am in the hall right now, I can look at the spot where I conducted much of this when I wasn't sacheting up and down the middle aisle where the trestle tables now are.And I wanted to give a kind of concerted voice to that enterprise. And I say "concerted voice" to give you a feel for the fact that I don't think this is a really an artifact. It's not a record. It's a exhortation that employs the things that happened to suggest that even though it is the way it is [00:15:00] ritually, impoverished as it is in our time and place, it has been otherwise within recoverable time and history. It has.And if that's true, and it is, then it seems to me at least is true that it could be otherwise again. And so, I made a fuss and I made a case based on that conviction.There's probably other reasons I can't think of right now. Oh, being not 25 anymore, and not having that many more books in me, the kind of wear and tear on your psyche of imposing order on the ramble, which is your recollection, which has only so many visitations available in it. Right? You can only do that so many times, I think. And I'm not a born writing person, you know, I come to it maniacally when I [00:16:00] do, and then when it's done, I don't linger over it so much.So then, when it's time to talk about it, I actually have to have a look, because the act of writing it is not the act of reading it. The act of writing is a huge delivery and deliverance at the same time. It's a huge gestation. And you can't do that to yourself, you know, over and over again, but you can take some chances, and look the thing in the eye. So, and I think some people who are there, they're kind of well-intended amongst them, will recognize themselves in the details of the book, beyond "this is what happened and so on." You know, they'll recognize themselves in the advocacy that's there, and the exhortations that are there, and the [00:17:00] case-making that I made and, and probably the praying because there's a good degree of prayerfulness in there, too.That's why.Chris: Thank you. bless this new one in the world. And what's the sense for you?Stephen: Oh, yes.Chris: It being a one-week old newborn. How's that landing in your days?Stephen: Well, it's still damp, you know. It's still squeaky, squeaky and damp. It's walking around like a newborn primate, you know, kind of swaying in the breeze and listening to port or to starboard according to whatever's going on.I don't know that it's so very self-conscious in the best sense of that term, yet. Even though I recorded the audio version, I don't think [00:18:00] it's my voice is found every nook and cranny at this point, yet. So, it's kind of new. It's not "news," but it is new to me, you know, and it's very early in terms of anybody responding to it.I mean, nobody around me has really taken me aside and say, "look, now I want to tell you about this book you wrote." It hasn't happened, and we'll see if it does, but I've done a few events on the other side of the ocean and hear so far, very few, maybe handful of interviews. And those are wonderful opportunities to hear something of what you came up with mismanaged by others, you know, misapprehend, you could say by others.No problem. I mean, it's absolutely no problem. And if you don't want that to happen, don't talk, don't write anything down. So, I don't mind a bit, you know, and the chances are very good that it'll turn into things I didn't have in mind [00:19:00] as people take it up, and regard their own weddings and marriages and plans and schemes and fears and, you know, family mishigas and all the rest of it through this particular lens, you know. They may pick up a pen or a computer (it's an odd expression, "pick up a computer"), and be in touch with me and let me know. "Yeah, that was, we tried it" or whatever they're going to do, because, I mean, maybe Die Wise provided a bit of an inkling of how one might be able to proceed otherwise in their dying time or in their families or their loved ones dying time.This is the book that most readily lends itself to people translating into something they could actually do, without a huge kind of psychic revolution or revolt stirring in them, at least not initially. This is as close as I come, probably, to writing a sequence of things [00:20:00] that could be considered "add-ons" to what people are already thinking about, that I don't force everybody else outta the house in order to make room for the ideas that are in the book. That may happen, anyway, but it wasn't really the intent. The intent was to say, you know, we are in those days when we're insanely preoccupied with the notion of a special event. We are on the receiving end of a considerable number of shards showing up without any notion really about what these shards remember or are memories of. And that's the principle contention I think that runs down the spine of the book, is that when we undertake matrimony, however indelicately, however by rote, you know, however mindlessly we may do it, [00:21:00] inadvertently, we call upon those shards nonetheless.And they're pretty unspectacular if you don't think about them very deeply, like the rice or confetti, like the aisle, like the procession up the aisle, like the giving away of someone, like the seating arrangement, like the spectacle seating arrangement rather than the ritual seating arrangement.And I mean, there's a fistful of them. And they're around and scholars aside maybe, nobody knows why they do them. Everybody just knows, "this is what a wedding is," but nobody knows why. And because nobody knows why, nobody really seems to know what a wedding is for, although they do proceed like they would know a wedding if they saw one. So, I make this a question to be really wondered about, and the shards are a way in. They're the kind of [00:22:00] breadcrumb trail through the forest. They're the little bits of broken something, which if you begin to handle just three or four of them, and kind of fit them together, and find something of the original shape and inflection of the original vessel, kind of enunciates, begins to murmur in your hands, and from it you can begin to infer some three-dimensionality to the original shape. And from the sense of the shape, you get a set sense of contour, and from the sense of contour, you get a sense of scale or size. And from that you get a sense of purpose, or function, or design. And from that you get a sense of some kind of serious magisterial insight into some of the fundament of human being that was manifest in the "old-order matrimony," [00:23:00] as I came to call it.So, who wouldn't wanna read that book?Chris: Mm-hmm.Thank you. Mm-hmm. Thank you, Stephen. Yeah. It reminds me, just before coming up here, maybe two weeks ago, I was in attending a wedding. And there was a host or mc, and initially just given what I was hearing over the microphone, it was hard to tell if he was hired or family or friends. And it turned out he was, in fact, a friend of the groom. And throughout the night he proceeded to take up that role as a kind of comedian.Audience: Mm-hmm.Chris: This was the idea, I guess. Mm-hmm. And he was buzzing and mumbling and swearing into the microphone, [00:24:00] and then finally minimizing the only remnant of traditional culture that showed up in the wedding. And his thing was, okay, so when can we get to the part where it's boom, boom, boom, right. And shot, shot, shot, whatever.Stephen: Right.Chris: There was so much that came up in my memories in part because I worked about a decade in Toronto in the wedding industry.Mm-hmm. Hospitality industry. Maybe a contradiction in terms, there. And there was one moment that really kind of summed it up. I kept coming back to this reading the book because it was everything that you wrote seemed to not only antithetical to this moment, but also an antidote.Anyways, it was in North Toronto and the [00:25:00] owner of the venue - it was a kind of movie theatre turned event venue - and there was a couple who was eventually going to get married there. They came in to do their tasting menu to see what they wanted to put on the menu for the dinner, for their wedding.And the owner was kind of this mafioso type. And he comes in and he sees them and he walks over and he says, "so, you're gonna get married at my wedding factory."Audience: Mm-hmm.Chris: In all sincerity.Stephen: Mm-hmm.Chris: Right.Without skipping a beat. Could you imagine?Stephen: Yeah.I could. I sure could.Chris: Yeah. Yeah.Stephen: I mean, don't forget, if these people weren't doing what the people wanted, they'd be outta business.Audience: Mm-hmm.Stephen: No, that's the thing. This is aiding and abetting. This is sleeping with the enemy, stylistically-speaking. [00:26:00] The fact that people "settle" (that's the term I would use for it), settle for this, the idea being that this somehow constitutes the most honest and authentic through line available to us is just jaw dropping. When you consider what allegedly this thing is supposed to be for. I mean, maybe we'll get into this, but I'll just leave this as a question for now. What is that moment allegedly doing?Not, what are the people in it allegedly doing? The moment itself, what is it? How is it different from us sitting here now talking about it? And how is it different from the gory frigging jet-fuelled aftermath of excess. And how's it different from the cursing alleged master of ceremonies? How can you [00:27:00] tell none of those things belong to this thing?And why do you have such a hard time imagining what doesAudience: Hmm mmChris: Well that leads me to my next question.Stephen: Ah, you're welcome.Chris: So, I've pulled a number of quotes from the book to read from over the course of the interview. And this one for anyone who's listening is on page 150. And you write Stephen,"Spiritually-speaking, most of the weddings in our corner of the world are endogamous affairs, inward-looking. What is, to me, most unnerving is that they can be spiritually-incestuous. The withering of psychic difference between people is the program of globalization. It is in the architecture of most things partaking of the internet, and it is in the homogeneity of our matrimony. [00:28:00] It is this very incestuous that matrimony was once crafted and entered into to avoid and subvert. Now, it grinds upon our differences until they are details.And so, this paragraph reminded me of a time in my youth when I seemed to be meeting couples who very eerily looked like each other. No blood or extended kin relation whatsoever, and yet they had very similar faces. And so as I get older, this kind of face fidelity aside, I continue to notice that people looking for companionship tend to base their search on similitude, on shared interests, customs, experiences, shared anything and everything. This, specifically, in opposition to those on the other side of the aisle or spectrum, to difference or divergence. And so, opposites don't attract anymore. I'm curious what you think this psychic [00:29:00] withering does to an achieve understanding of matrimony.Stephen: Well, I mean, let's wonder what it does to us, generally, first before we get to matrimony, let's say. It demonizes. Maybe that's too strong, but it certainly reconstitutes difference as some kind of affliction, some kind of not quite good enough, some kind of something that has to be overcome or overwhelmed on the road to, to what? On the road to sameness? So, if that's the goal, then are all of the differences between us, aberrations of some kind, if that's the goal? If that's the goal, are all the [00:30:00] differences between us, not God-given, but humanly misconstrued or worse? Humanly wrought? Do the differences between us conceivably then belong at all? Or is the principle object of the entire endeavor to marry yourself, trying to put up with the vague differences that the other person represents to you?I mean, I not very jokingly said years ago, that I coined a phrase that went something like "the compromise of infinity, which is other people." What does that mean? "The compromise of infinity, which is other people." Not to mention it's a pretty nice T-shirt. But what I meant by the [00:31:00] phrase is this: when you demonize difference in this fashion or when you go the other direction and lionize sameness, then one of the things that happens is that compromise becomes demonized, too. Compromise, by definition, is something you never should have done, right? Compromise is how much you surrender of yourself in order to get by. That's what all these things become. And before you know it, you're just beaten about the head and shoulders about "codependence" and you know, not being "true to yourself" as if being true to yourself is some kind of magic.I mean, the notion that "yourself is the best part of you" is just hilarious. I mean, when you think about it, like who's running amuck if yourself is what you're supposed to be? I ask you. Like, who's [00:32:00] doing the harm? Who's going mental if the self is such a good idea? So, of course, I'm maintaining here that I'm not persuaded that there is such a thing.I think it's a momentary lapse in judgment to have a self and to stick to it. That's the point I'm really making to kind of reify it until it turns ossified and dusty and bizarrely adamant like that estranged relative that lives in the basement of your house. Bizarrely, foreignly adamant, right? Like the house guest who just won't f**k off kind of thing.Okay, so "to thine own self be true," is it? Well, try being true to somebody else's self for ten minutes. Try that. [00:33:00] That's good at exercise for matrimony - being true to somebody else's self. You'll discover that their selves are not made in heaven, either. Either. I underscore it - either. I've completely lost track of the question you asked me.Chris: What are the consequences of the sameness on this anti-cultural sameness, and the program of it for an achieved understanding of matrimony.Stephen: Thank you. Well, I will fess up right now. I do so in the book. That's a terrible phrase. I swear I'd never say such a thing. "In my book... I say the following," but in this case, it's true. I did say this. I realized during the writing of it that I had made a tremendous tactical error in the convening of the event as I did it over the years, [00:34:00] and this is what it came to.I was very persuaded at the time of the story that appears in the chapter called "Salt and Indigo" in the book. I was very, very persuaded. I mean, listen, I made up the story (for what it's worth), okay, but I didn't make it up out of nothing. I made it up out of a kind of tribal memory that wouldn't quite let go.And in it, I was basically saying, here's these two tribes known principally for what they trade in and what they love most emphatically. They turn out to be the same thing. And I describe a circumstance in which they exchange things in a trade scenario, not a commerce scenario. And I'm using the chapter basically to make the case that matrimony's architecture derives in large measure from the sacraments of trade as manifest in that story. [00:35:00] Okay. And this is gonna sound obvious, but the fundamental requirement of the whole conceit that I came up with is that there are two tribes. Well, I thought to myself, "of course, there's always two tribes" at the time. And the two tribe-ness is reflected in when you come to the wedding site, you're typically asked (I hope you're still asked) " Are you family or friend of the groom or friend of the bride?" And you're seated "accordingly," right? That's the nominal, vestigial shard of this old tribal affiliation, that people came from over the rise, basically unknown to each other, to arrive at the kind of no man's land of matrimony, and proceeded accordingly. So, I put these things into motion in this very room and I sat people accordingly facing each other, not facing the alleged front of the room. [00:36:00] And of course, man, nobody knew where to look, because you raised your eyes and s**t. There's just humans across from you, just scads of them who you don't freaking know. And there's something about doing that to North Americas that just throws them. So, they're just looking at each other and then looking away, and looking at each other and looking away, and wondering what they're doing here and what it's for. And I'm going back and forth for three hours, orienting them as to what is is coming.Okay, so what's the miscalculation that I make? The miscalculation I made was assuming that by virtue of the seating arrangement, by virtue of me reminding them of the salt and indigo times, by virtue of the fact that they had a kind of allegiance of some sort or another to the people who are, for the moment, betrothed, that those distinctions and those affiliations together would congeal them, and constitute a [00:37:00] kind of tribal affiliation that they would intuitively be drawn towards as you would be drawn to heat on a cold winter's night.Only to discover, as I put the thing into motion that I was completely wrong about everything I just told you about. The nature of my error was this, virtually all of those people on one side of the room were fundamentally of the same tribe as the people on the other side of the room, apropos of your question, you see. They were card carrying members of the gray dominant culture of North America. Wow. The bleached, kind of amorphous, kind of rootless, ancestor-free... even regardless of whether their people came over in the last generation from the alleged old country. It doesn't really claim them.[00:38:00]There were two tribes, but I was wrong about who they were. That was one tribe. Virtually everybody sitting in the room was one tribe.So, who's the other tribe? Answer is: me and the four or five people who were in on the structural delivery of this endeavour with me. We were the other tribe.We didn't stand a chance, you see?And I didn't pick up on that, and I didn't cast it accordingly and employ that, instead. I employed the conceit that I insisted was manifest and mobilized in the thing, instead of the manifest dilemma, which is that everybody who came knew what a wedding was, and me and four or five other people were yet to know if this could be one. That was the tribal difference, if you [00:39:00] will.So, it was kind of invisible, wasn't it? Even to me at the time. Or, I say, maybe especially to me at the time. And so, things often went the way they went, which was for however much fascination and willingness to consider that there might have been in the room, there was quite a bit more either flat affect and kind of lack of real fascination, or curiosity, or sometimes downright hostility and pushback. Yeah.So, all of that comes from the fact that I didn't credit as thoroughly as I should have done, the persistence in Anglo-North America of a kind of generic sameness that turned out to be what most people came here ancestrally to become. "Starting again" is recipe for culture [00:40:00] loss of a catastrophic order. The fantasy of starting again. Right?And we've talked about that in your podcast, and you and I have talked about it privately, apropos of your own family and everybody's sitting in this room knows what I'm talking about. And when does this show up? Does it show up, oh, when you're walking down the street? Does it show up when you're on the mountaintop? Does it show up in your peak experiences? And the answer is "maybe." It probably shows up most emphatically in those times when you have a feeling that something special is supposed to be so, and all you can get from the "supposed to" is the allegation of specialness.Audience: Mm-hmm.Stephen: And then, you look around in the context of matrimony and you see a kind of febral, kind of strained, the famous bridezilla stuff, all of that stuff. [00:41:00] You saw it in the hospitality industry, no doubt. You know, the kind of mania for perfection, as if perfection constitutes culture. Right? With every detail checked off in the checkbox, that's culture. You know, as if everything goes off without a hitch and there's no guffaws. And in fact, anybody could reasonably make the case, "Where do you think culture appears when the script finally goes f*****g sideways?" That's when. And when you find out what you're capable of, ceremonially.And generally speaking, I think most people discovered that their ceremonial illiteracy bordered on the bottomless.That's when you find out. Hmm.Chris: Wow.Stephen: Yeah. And that's why people, you know, in speech time, they reach in there and get that piece of paper, and just look at it. Mm-hmm. They don't even look up, terrified that they're gonna go off script for a minute as [00:42:00] if the Gods of Matrimony are a scripted proposition.Chris: Mm-hmm. Yeah. Thank you for sharing that with us, that degree of deep reflection and humility that I'm sure comes with it.Stephen: Mea Culpa, baby. Yeah, I was, I got that one totally wrong. Mm-hmm. And I didn't know it at the time. Meanwhile, like, how much can you transgress and have the consequences of doing so like spill out across the floor like a broken thermometer's mercury and not wise up.But of course, I was as driven as anybody. I was as driven to see if I could come through with what I promised to do the year before. And keeping your promise can make you into a maniac.Audience: Hmm hmm.Chris: But I imagine that, you [00:43:00] know, you wouldn't have been able to see that even years later if you didn't say yes in the first place.Stephen: Oh, yeah. Yeah. And I wouldn't have been able to make the errors.Chris: Right.Stephen: Right. Yeah. I mean, as errors go, this is not a mortal sin. Right, right. And you could chalk it up to being a legitimate miscalculation. Well, so? All I'm saying is, it turns out I was there too, and it turns out, even though I was allegedly the circus master of the enterprise, I wasn't free and clear of the things we were all contending with, the kind of mortality and sort of cultural ricketiness that were all heirs to. That's how I translated it, as it turns out.So, PS there was a moment, [00:44:00] which I don't remember which setting it was now, but there was a moment when the "maybe we'll see if she becomes a bride" bride's mother slid up to me during the course of the proceedings, and in a kind of stage whisper more or less hissed me as follows."Is this a real wedding?"I mean, that's not a question. Not in that setting, obviously not. That is an accusation. Right. And a withering one at that. And there was a tremendous amount of throw-down involved.So, was it? I mean, what we do know is that she did not go to any of the weddings [00:45:00] that she was thinking of at the time, and go to the front of the room where the celebrant is austerely standing there with the book, or the script, or the well-intentioned, or the self-penned vows and never hissed at him or her, "is this a real wedding?"Never once did she do that. We know that.Right.And I think we know why. But she was fairly persuaded she knew what a real wedding was. And all she was really persuaded by was the poverty of the weddings that she'd attended before that one. Well, I was as informed in that respect as she was, wasn't I? I just probably hadn't gone to as many reprobate weddings as she had, so she had more to deal with than I did, even though I was in the position of the line of fire.And I didn't respond too well to the question, I have to say. At the moment, I was rather combative. But I mean, you try to do [00:46:00] what I tried to do and not have a degree of fierceness to go along with your discernment, you know, just to see if you can drag this carcass across the threshold. Anyway, that happened too.Chris: Wow. Yeah. Dominant culture of North America.Stephen: Heard of it.Chris: Yeah. Well, in Matrimony, there's quite a bit in which you write about hospitality and radical hospitality. And I wanted to move in that direction a little bit, because in terms of these kind of marketplace rituals or ceremonies that you were mentioning you know, it's something that we might wonder, I think, as you have, how did it come to be this [00:47:00] way?And so I'd like to, if I can once again, quote from matrimony in which you speak to the etymology of hospitality. And so for those interested on page 88,"the word hospitality comes from hospitaller, meaning 'one who cares for the afflicted, the infirm, the needy.' There's that thread of our misgivings about being on the receiving end of hospitality. Pull on it. For the written history of the word, at least, it has meant, 'being on the receiving end of a kind of care you'd rather not need.'"End quote.Stephen: That's so great. I mean, before you go on with the quote. It's so great to know that the word, unexamined, just kind of leaks upside, doesn't it? Hospitality, I mean, nobody goes "Hospitality, ew." [00:48:00] And then, if you just quietly do the obvious math to yourself, there's so much awkwardness around hospitality.This awkwardness must have an origin, have a home. There must be some misgiving that goes along with the giving of hospitality, mustn't there be? How else to understand where that kind of ickiness is to be found. Right? And it turns out that the etymology is giving you the beginnings of a way of figuring it out what it is that you're on the receiving end of - a kind of succor that you wish you didn't need, which is why it's the root word for "hospital."Chris: Hmm hmm. Wow.Audience: Hmm.Chris: May I repeat that sentence please? Once more."For the written history of the word, at least, it has meant, [00:49:00] 'being on the receiving end of a kind of care you'd rather not need.'"And so this last part hits home for me as I imagine it does for many.And it feels like the orthodoxy of hospitality in our time is one based not only in transaction, but in debt. And if you offer hospitality to me, then I owe you hospitality.Stephen: Right.Chris: I'm indebted to you. And we are taught, in our time, that the worst thing to be in is in debt.Stephen: Right?Chris: And so people refuse both the desire to give as well as the learning skill of receiving. And this is continuing on page 88 now."But there's mystery afoot with this word. In its old Latin form, hospice meant both 'host' and 'guest.'"Stephen: Amazing. One. Either one, This is absolutely amazing. We're fairly sure that there's a [00:50:00] acres of difference between the giver of hospitality and the receiver that the repertoire is entirely different, that the skew between them is almost insurmountable, that they're not interchangeable in any way. But the history of the word immediately says, "really?" The history of the word, without question, says that "host" and "guest" are virtually the same, sitting in different places, being different people, more or less joined at the hip. I'll say more, but you go ahead with what you were gonna do. Sure.Chris: "In it's proto Indo-European origins, hospitality and hospice is a compound word: gosh + pot. And it meant something like [00:51:00] 'stranger/guest/host + powerful Lord.'It is amazing to me that ancestrally, the old word for guest, host, and stranger were all the same word. Potent ceremonial business, this is. In those days, the server and the serve were partners in something mysterious. This could be confusing, but only if you think of guest, host, and stranger as fixed identities.If you think of them as functions, as verbs, the confusion softens and begins to clear. The word hospice in its ancient root is telling us that each of the people gathered together in hospitality is bound to the others by formal etiquette, yes, but the bond is transacted through a subtle scheme of graces.Hospitality, it tells us, is a web of longing and belonging that binds people for a time, some hithereto unknown to each other is a clutch of mutually-binding elegances, you could say. In its ancient practice, [00:52:00] hospitality was a covenant. According to that accord, however we were with each other. That was how the Gods would be with us. We learn our hospitality by being on the receiving end of Godly administration. That's what giving thanks for members. We proceed with our kin in imitation of that example and in gratitude for it."Mm-hmm.And so today, among "secular" people, with the Gods ignored, this old-time hospitality seems endangered, if not fugitive. I'm curious how you imagine that this rupture arose, the ones that separated and commercialized the radical relationships between hosts and guests, that turned them from verbs to nouns and something like strangers to marketplace functions.[00:53:00]Stephen: Well, of course this is a huge question you've asked, and I'll see if I can unhuge it a bit.Chris: Uhhuh.Stephen: Let's go right to the heart of what happened. Just no preliminaries, just right to it.So, to underscore again, the beauty of the etymology. I've told you over and over again, the words will not fail you. And this is just a shining example, isn't it? That the fraternization is a matter of ceremonial alacrity that the affiliation between host and guest, which makes them partners in something, that something is the [00:54:00] evocation of a third thing that's neither one of them. It's the thing they've lent themselves to by virtue of submitting to being either a host or a guest. One.Two. You could say that in circumstances of high culture or highly-functioning culture, one of the principle attributes of that culture is that the fundament of its understanding, is that only with the advent of the stranger in their midst that the best of them comes forward.Okay, follow that. Yeah.So, this is a little counterintuitive for those of us who don't come from such places. We imagine that the advent of strangers in the midst of the people I'm describing would be an occasion where people hide their [00:55:00] best stuff away until the stranger disappears, and upon the disappearance of the stranger, the good stuff comes out again.You know?So, I'm just remembering just now, there's a moment in the New Testament where Jesus says something about the best wine and he's coming from exactly this page that we're talking about - not the page in the book, but this understanding. He said, you know, "serve your best wine first," unlike the standard, that prevails, right?So again, what a stranger does in real culture is call upon the cultural treasure of the host's culture, and provides the opportunity for that to come forward, right? By which you can understand... Let's say for simplicity's sake, there's two kinds of hospitality. There's probably all kinds of gradations, [00:56:00] but for the purposes of responding to what you've asked, there's two.One of them is based on kinship. Okay? So, family meal. So, everybody knows whose place is whose around the table, or it doesn't matter - you sit wherever you want. Or, when we're together, we speak shorthand. That's the shorthand of familiarity and affinity, right?Everybody knows what everybody's talking about. A lot of things get half-said or less, isn't it? And there's a certain fineness, isn't it? That comes with that kind of affinity. Of course, there is, and I'm not diminishing it at all. I'm just characterizing it as being of a certain frequency or calibre or charge. And the charge is that it trades on familiarity. It requires that. There's that kind of hospitality."Oh, sit wherever you want."Remember this one?[00:57:00]"We don't stand on ceremony here.""Oh, you're one of the family now." I just got here. What, what?But, of course, you can hear in the protestations the understanding, in that circumstance, that formality is an enemy to feeling good in this moment, isn't it? It feels stiff and starched and uncalled for or worse.It feels imported from elsewhere. It doesn't feel friendly. So, I'm giving you now beginnings of a differentiation between how cultures who really function as cultures understand what it means to be hospitable and what often prevails today, trading is a kind of low-grade warfare conducted against the strangeness of the stranger.The whole purpose of treating somebody like their family is to mitigate, and finally neutralize their [00:58:00] strangeness, so that for the purposes of the few hours in front of us all, there are no strangers here. Right? Okay.Then there's another kind, and intuitively you can feel what I'm saying. You've been there, you know exactly what I mean.There's another kind of circumstance where the etiquette that prevails is almost more emphatic, more tangible to you than the familiar one. That's the one where your mother or your weird aunt or whoever she might be, brings out certain kind of stuff that doesn't come out every day. And maybe you sit in a room that you don't often sit in. And maybe what gets cooked is stuff you haven't seen in a long time. And some part of you might be thinking, "What the hell is all this about?" And the answer is: it's about that guy in the [00:59:00] corner that you don't know.And your own ancestral culture told acres of stories whose central purpose was to convey to outsiders their understanding of what hospitality was. That is fundamentally what The Iliad and The Odyssey are often returning to and returning to and returning to.They even had a word for the ending of the formal hospitality that accrued, that arose around the care and treatment of strangers. It was called pomp or pompe, from which we get the word "pompous." And you think about what the word "pompous" means today.It means "nose in the air," doesn't it? Mm-hmm. It means "thinks really highly of oneself," isn't it? And it means "useless, encumbering, kind of [01:00:00] artificial kind of going through the motions stuff with a kind of aggrandizement for fun." That's what "pompous" means. Well, the people who gave us the word didn't mean that at all. This word was the word they used to describe the particular moment of hospitality when it was time for the stranger to leave.And when it was mutually acknowledged that the time for hospitality has come to an end, and the final act of hospitality is to accompany the stranger out of the house, out of the compound, out into the street, and provision them accordingly, and wish them well, and as is oftentimes practiced around here, standing in the street and waving them long after they disappear from view.This is pompous. This is what it actually means. Pretty frigging cool when you get corrected once in a while, isn't it? [01:01:00] Yeah.So, as I said, to be simplistic about it, there's at least a couple of kinds, and one of them treasures the advent of the stranger, understanding it to be the detonation point for the most elegant part of us to come forward.Now, those of us who don't come from such a place, we're just bamboozled and Shanghai'ed by the notion of formality, which we kind of eschew. You don't like formality when it comes to celebration, as if these two things are hostile, one to the other. But I'd like you to consider the real possibility that formality is grace under pressure, and that formality is there to give you a repertoire of response that rescues you from the gross limitations of your autobiography.[01:02:00]Next question. I mean, that's the beginning.Chris: Absolutely. Absolutely. Mm-hmm. Thank you once again, Stephen. So alongside the term or concept of "pompe," in which the the guest or stranger was led out of the house or to the entrance of the village, there was also the consideration around the enforcement of hospitality, which you write about in the book. And you write that"the enforcement of hospitality runs the palpable risk of violating or undoing the cultural value it is there to advocate for. Forcing people to share their good fortune with the less fortunate stretches, to the point of undoing the generosity of spirit that the culture holds dear. Enforcement of hospitality is a sign of the eclipse of hospitality, typically spawned by insecurity, contracted self-definition, and the darkening of the [01:03:00] stranger at the door.Instead, such places and times are more likely to encourage the practice of hospitality in subtle generous ways, often by generously treating the ungenerous."And so there seems to be a need for limits placed on hospitality, in terms of the "pompe," the maximum three days in which a stranger can be given hospitality, and concurrently a need to resist enforcing hospitality. This seems like a kind of high-wire act that hospitable cultures have to balance in order to recognize and realize an honorable way of being with a stranger. And so I'm wondering if you could speak to the possibility of how these limits might be practiced without being enforced. What might that look like in a culture that engages with, with such limits, but without prohibitions?Stephen: Mm-hmm. That's a very good question. [01:04:00] Well, I think your previous question was what happened? I think, in a nutshell, and I didn't really answer that, so maybe see how I can use this question to answer the one that you asked before: what happened? So, there's no doubt in my mind that something happened that it's kind of demonstrable, if only with the benefit of hindsight.Audience: Right.Stephen: Or we can feel our way around the edges of the absence of the goneness of that thing that gives us some feel for the original shape of that thing.So you could say I'm trafficking in "ideals," here, and after a fashion, maybe, yeah. But the notion of "ideals," when it's used in this slanderous way suggests that "it was never like that."Chris: Mm-hmm.Stephen: And I suggest to you it's been like that in a lot of places, and there's a lot of places where it's still like that, although globalization [01:05:00] may be the coup de grâce performed upon this capacity. Okay. But anyway.Okay. So what happened? Well, you see in the circumstance that I described, apropos of the stranger, the stranger is in on it. The stranger's principle responsibility is to be the vector for this sort of grandiose generosity coming forward, and to experience that in a burdensome and unreciprocated fashion, until you realize that their willingness to do that is their reciprocity. Everybody doesn't get to do everything at once. You can't give and receive at the same time. You know what that's called? "Secret Santa at school," isn't it?That's where nobody owes nobody nothing at the end. That's what we're all after. I mean, one of your questions, you know, pointed to that, that there's a kind of, [01:06:00] what do you call that, teeter-totter balance between what people did for each other and what they received for each other. Right. And nobody feels slighted in any way, perfect balance, et cetera.Well, the circumstance here has nothing of the kind going with it. The circumstance we're describing now is one in which the hospitality is clearly unequal in terms of who's eating whose food, for example, in terms of the absolutely frustrated notion of reciprocity, that in fact you undo your end of the hospitality by trying to pay back, or give back, or pay at all, or break even, or not feel the burden of "God, you've been on the take for fricking hours here now." And if you really look in the face of the host, I mean, they're just getting started and you can't, you can't take it anymore.[01:07:00]So, one of the ways that we contend with this is through habits of speech. So, if somebody comes around with seconds. They say, "would you like a little more?"And you say, "I'm good. I'm good. I'm good." You see, "I'm good" is code for what? "F**k off." That's what it's code for. It's a little strong. It's a little strong. What I mean is, when "I'm good" comes to town, it means I don't need you and what you have. Good God, you're not there because you need it you knucklehead. You're there because they need it, because their culture needs an opportunity to remember itself. Right?Okay. So what happened? Because you're making it sound like a pretty good thing, really. Like who would say, "I think we've had enough of this hospitality thing, don't you? Let's try, oh, [01:08:00] keeping our s**t to ourselves. That sounds like a good alternative. Let's give it a week or two, see how it rolls." Never happened. Nobody decided to do this - this change, I don't think. I think the change happened, and sometime long after people realized that the change had had taken place. And it's very simple. The change, I think, went something like this.As long as the guest is in on it, there's a shared and mutually-held understanding that doesn't make them the same. It makes them to use the quote from the book "partners," okay, with different tasks to bring this thing to light, to make it so. What does that require? A mutually-held understanding in vivo as it's happening, what it is.Okay. [01:09:00] So, that the stranger who's not part of the host culture... sorry, let me say this differently.The culture of the stranger has made the culture of the host available to the stranger no matter how personally adept he or she may be at receiving. Did you follow that?Audience: A little.Stephen: Okay. Say it again?Audience: Yes, please.Stephen: Okay. The acculturation, the cultured sophistication of the stranger is at work in his or her strangerhood. Okay. He or she's not at home, but their cultural training helps them understand what their obligations are in terms of this arrangement we've been describing here.Okay, so I think the rupture takes place [01:10:00] when the culturation of one side or the other fails to make the other discernible to the one.One more time?When something happens whereby the acculturation of one of the partners makes the identity, the presence, and the valence of the other one untranslatable. Untranslatable.I could give you an example from what I call " the etiquette of trade," or the... what was the word? Not etiquette. What's the other word?Chris: The covenant?Stephen: Okay, " covenant of trade" we'll call it. So, imagine that people are sitting across from each other, two partners in a trade. Okay? [01:11:00] Imagine that they have one thing to sell or move or exchange and somebody has something else.How does this work? Not "what are the mechanics?" That can be another discussion, but, if this works, how does it work? Not "how does it happen?" How does it actually achieve what they're after? Maybe it's something like this.I have this pottery, and even though you're not a potter, but somebody in your extended family back home was, and you watched what they went through to make a fricking pot, okay?You watched how their hands seized up, because the clay leached all the moisture out of the hands. You distinctly remember that - how the old lady's hands looked cracked and worn, and so from the work of making vessels of hospitality, okay? [01:12:00] It doesn't matter that you didn't make it yourself. The point is you recognize in the item something we could call "cultural patrimony."You recognize the deep-runningness of the culture opposite you as manifest and embodied in this item for trade. Okay? So, the person doesn't have to "sell you" because your cultural sophistication makes this pot on the other side available to you for the deeply venerable thing that it is. Follow what I'm saying?Okay. So, you know what I'm gonna say next? When something happens, the items across from you cease to speak, cease to have their stories come along with them, cease to be available. There's something about your cultural atrophy that you project onto the [01:13:00] item that you don't recognize.You don't recognize it's valence, it's proprieties, it's value, it's deep-running worth and so on. Something happened, okay? And because you're not making your own stuff back home or any part of it. And so now, when you're in a circumstance like this and you're just trying to get this pot, but you know nothing about it, then the enterprise becomes, "Okay, so what do you have to part with to obtain the pot?"And the next thing is, you pretend you're not interested in obtaining the pot to obtain the pot. That becomes part of the deal. And then, the person on the making end feels the deep running slight of your disinterest, or your vague involvement in the proceedings, or maybe the worst: when it's not things you're going back and forth with, but there's a third thing called money, which nobody makes, [01:14:00] which you're not reminded of your grandma or anyone else's with the money. And then, money becomes the ghost of the original understanding of the cultural patrimony that sat between you. That's what happened, I'm fairly sure: the advent, the estrangement that comes with the stranger, instead of the opportunity to be your cultural best when the stranger comes.And then of course, it bleeds through all kinds of transactions beyond the "obvious material ones." So, it's a rupture in translatability, isn't it?Chris: You understand this to happen or have happened historically, culturally, et cetera, with matrimony as well?Stephen: Oh, absolutely. Yeah.Yeah. This is why, for example, things like the fetishization of virginity.Audience: Mm-hmm. [01:15:00]Stephen: I think it's traceable directly to what we're talking about. How so? Oh, this is a whole other long thing, but the very short version would be this.Do you really believe that through all of human history until the recent liberation, that people have forever fetishized the virginity of a young woman and jealously defended it, the "men" in particular, and that it became a commodity to trade back and forth in, and that it had to be prodded and poked at to determine its intactness? And this was deemed to be, you know, honourable behavior?Do you really think that's the people you come from, that they would've do that to the most cherished of their [01:16:00] own, barely pubescent girls? Come on now. I'm not saying it didn't happen and doesn't still happen. I'm not saying that. I'm saying, God almighty, something happened for that to be so.And I'm trying to allude to you now what I think took place. Then all of a sudden, the hymen takes the place of the pottery, doesn't it? And it becomes universally translatable. Doesn't it? It becomes a kind of a ghosted artifact of a culturally-intact time. It's as close as you can get.Hence, this allegation of its purity, or the association with purity, and so on. [01:17:00] I mean, there's lots to say, but that gives you a feel for what might have happened there.Chris: Thank you, Stephen. Thank you for being so generous with your considerations here.Stephen: You see why I had to write a book, eh?Audience: Mm-hmm.Stephen: There was too much bouncing around. Like I had to just keep track of my own thoughts on the matter.But can you imagine all of this at play in the year, oh, I don't know, 2022, trying to put into motion a redemptive passion play called "matrimony," with all of this at play? Not with all of this in my mind, but with all of this actually disfiguring the anticipation of the proceedings for the people who came.Can you imagine? Can you imagine trying to pull it off, and [01:18:00] contending overtly with all these things and trying to make room for them in a moment that's supposed to be allegedly - get ready for it - happy.I should have raised my rates on the first day, trying to pull that off.But anyway.Okay, you go now,Chris: Maybe now you'll have the opportunity.Stephen: No, man. No. I'm out of the running for that. "Pompe" has come and come and gone. Mm.Chris: So, in matrimony, Stephen, you write that"the brevity, the brevity of modern ceremonies is really there to make sure that nothing happens, nothing of substance, nothing of consequence, no alchemy, no mystery, no crazy other world stuff. That overreach there in its scripted heart tells me that deep in the rayon-wrapped bosom of that special day, the modern wedding is scared [01:19:00] silly of something happening. That's because it has an ages-old abandoned memory of a time when a wedding was a place where the Gods came around, where human testing and trying and making was at hand, when the dead lingered in the wings awaiting their turn to testify and inveigh."Gorgeous. Gorgeous.Audience: Mm-hmm.Chris: And so I'm curious ifStephen: "Rayon-wrapped bosom." That's not, that's not shabby.Chris: "Rayon-wrapped bosom of that special day." Yeah.So, I'm curious do you think the more-than-human world practices matrimony, and if so, what, if anything, might you have learned about matrimony from the more-than-human world?Stephen: I would say the reverse. I would say, we practice the more-than-human world in matrimony, not that the more-than-human world practices matrimony. We practice them, [01:20:00] matrimonially.Next. Okay. Or no? I just gonna say that, that's pretty good.Well, where do we get our best stuff from? Let's just wonder that. Do we get our best stuff from being our best? Well, where does that come from? And this is a bit of a barbershop mirrors situation here, isn't it? To, to back, back, back, back.If you're thinking of time, you can kind of get lost in that generation before, or before, before, before. And it starts to sound like one of them biblical genealogies. But if you think of it as sort of the flash point of multiple presences, if you think of it that way, then you come to [01:21:00] credit the real possibility that your best stuff comes from you being remembered by those who came before you.Audience: Hmm.Stephen: Now just let that sit for a second, because what I just said is logically-incompatible.Okay? You're being remembered by people who came before you. That's not supposed to work. It doesn't work that way. Right?"Anticipated," maybe, but "remembered?" How? Well, if you credit the possibility of multiple beginnings, that's how. Okay. I'm saying that your best stuff, your best thoughts, not the most noble necessarily. I would mean the most timely, [01:22:00] the ones that seem most needed, suddenly.You could take credit and sure. Why, why not? Because ostensibly, it arrives here through you, but if you're frank with yourself, you know that you didn't do that on command, right? I mean, you could say, I just thought of it, but you know in your heart that it was thought of and came to you.I don't think there's any difference between saying that and saying you were thought of.Audience: Mm-hmm.Stephen: So, that's what I think the rudiments of old-order matrimony are. They are old people and their benefactors in the food chain and spiritually speaking. Old people and their benefactors, the best part of them [01:23:00] willed to us, entrusted and willed to us. So, when you are willing to enter into the notion that old-order matrimony is older than you, older than your feelings for the other person, older than your love, and your commitment, and your willingness to make the vows and all that stuff, then you're crediting the possibility that your love is not the beginning of anything.You see. Your love is the advent of something, and I use that word deliberately in its Christian notion, right? It's the oncomingness, the eruption into the present day of something, which turns out to be hugely needed and deeply unsuspected at the same time.I used to ask in the school, "can you [01:24:00] have a memory of something you have no lived experience of?" I think that's what the best part of you is. I'm not saying the rest of you is shite. I'm not saying that. You could say that, but I am saying that when I say "the best part of you," that needs a lot of translating, doesn't it?But the gist of it is that the best part of you is entrusted to you. It's not your creation, it's your burden, your obligation, your best chance to get it right. And that's who we are to those who came before us. We are their chance to get it right, and matrimony is one of the places where you practice the gentle art of getting it right.[01:25:00] Another decent reason to write a book.Chris: So, gorgeous. Wow. Thank you Stephen. I might have one more question.Stephen: Okay. I might have one more answer. Let's see.Chris: Alright. Would I be able to ask if dear Nathalie Roy could join us up here alongside your good man.So, returning to Matrimony: Ritual, Culture and the Heart's Work. On page 94, [01:26:00] Stephen, you write that"hospitality of the radical kind is

Nouveaux pilotes, un brin déjantés, à bord de la Libre Antenne sur RMC ! Jean-Christophe Drouet et Julien Cazarre prennent le relais. Après les grands matchs, quand la lumière reste allumée pour les vrais passionnés, place à la Libre Antenne : un espace à part, entre passion, humour et dérision, débats enflammés, franc-parler et second degré. Un rendez-vous nocturne à la Cazarre, où l'on parle foot bien sûr, mais aussi mauvaise foi, vannes, imitations et grands moments de radio imprévisibles !

Plusieurs débats au cœur de l'actualité, les Grandes gueules ont le choix, en débattre ou non : Les prix à la pompe repartent à la hausse Le salaire, sujet tabou entre collègues Une intelligence artificielle nommée ministre en Albanie

Silvia and Rodrigo are joined by Dr Ray Wang, Director of the multidisciplinary Foundation of Caring Lysosomal Storage Disorder Program at the Children's Hospital of Orange County. Silvia asks Dr Wang and Rodrigo (who also happens to be a researcher in this field) about cutting-edge advances in LSD research: from base editing in Pompe disease and patient-specific in vivo gene editing, to new biomarkers and scoring systems in Gaucher disease, insights into lipid dysregulation across lysosomal storage disorders, and the first clinical trial of anakinra in Sanfilippo syndrome. Papers discussed include: Christensen CL, et al Base editing rescues acid α-glucosidase function in infantile-onset Pompe disease patient-derived cells. Mol Ther Nucleic Acids. 2024 May 21;35(2):102220. doi: 10.1016/j.omtn.2024.102220. PMID: 38948331; PMCID: PMC11214518. Starosta RT, et al Predicting liver fibrosis in Gaucher disease: Investigation of contributors and development of a clinically applicable Gaucher liver fibrosis score. Mol Genet Metab. 2025 Feb;144(2):109010. doi: 10.1016/j.ymgme.2025.109010. Epub 2025 Jan 3. PMID: 39788861. Kell P, et al Secondary accumulation of lyso-platelet activating factors in lysosomal storage diseases. Mol Genet Metab. 2025 Jun 17;145(4):109180. doi: 10.1016/j.ymgme.2025.109180. Polgreen LE, et al Anakinra in Sanfilippo syndrome: a phase 1/2 trial. Nat Med. 2024 Sep;30(9):2473-2479. doi: 10.1038/s41591-024-03079-3. Epub 2024 Jun 21. Erratum in: Nat Med. 2024 Sep;30(9):2693. doi: 10.1038/s41591-024-03207-z. Musunuru K, et al Patient-Specific In Vivo Gene Editing to Treat a Rare Genetic Disease. N Engl J Med. 2025 Jun 12;392(22):2235-2243. doi: 10.1056/NEJMoa2504747.

On the 135th episode of the What is a Good Life? podcast, I'm delighted to welcome our guest, Stephen Jenkinson. Stephen is a cultural worker, teacher, author, and ceremonialist. He is the creator and principal instructor of the Orphan Wisdom School, founded in 2010. He has master's degrees from Harvard University (theology) and the University of Toronto (social work). He's the author of Come of Age, the award-winning Die Wise, Money and the Soul's Desires, and Reckoning (with Kimberly Ann Johnson). His latest book, Matrimony: Ritual, Culture and the Heart's Work, invites readers to contemplate the significance of matrimony, ceremony, and cultural articulation—and how to redeem them for future generations.In this rich conversation, Stephen explores profound questions about life, love, and the nature of existence. The discussion delves into the essence of ceremonies, particularly in matrimony, emphasising the need for meaningful endings and the responsibilities we hold towards future generations. The discussion weaves fate, ancestry, humility, and the call to “proceed as if you're needed” into a meditation on how we might live fully inhabited lives.For Stephen's latest book, Matrimony:To buy your copy: https://orphanwisdom.com/store/matrimony/About the book: https://orphanwisdom.com/books/matrimony/For more of Stephen's work: Website: https://orphanwisdom.com/Contact me at mark@whatisagood.life if you'd like to explore your own lines of self-inquiry through 1-on-1 coaching, my 5-week group courses, or to discuss experiences I create to stimulate greater trust, communication, and connection, amongst your leadership teams.- For the What is a Good Life? podcast's YouTube page: https://www.youtube.com/@whatisagoodlife/videos- My newsletter: https://www.whatisagood.life/- My LinkedIn: https://www.linkedin.com/in/mark-mccartney-14b0161b4/00:01 – Introduction01:37 – The Condition of Pondering06:28 – Roots of Pondering10:16 – The Dream Another World Has of You19:36 – Needed vs Important21:46 – Matrimony and the Presence of the Absence26:00 – Longing and Belonging 31:00 – Modern wedding and the privatisation of love35:47 – The Art of the Ending41:40 – Pompe and the Necessity of Closure43:47 – Ritual as a Gift to the Village45:45 – The White Heat of Possibility51:25 – The Active Witness53:43 – What Is a Good Life for Stephen?

In this episode, Prof Chris Vorster (Director, Centre for Human Metabolomics, North-West University, South Africa), Sarah Viall (Assistant Professor, Molecular and Medical Genetics, Oregon Health & Science University, USA) and PD Dr. med. Ulrike Mütze (Consultant, Heidelberg University Hospital, Germany) join Silvia Radenkovic and Rodrigo Starosta to explore the evolving landscape of newborn screening. They discuss national and international variations in practice, how to maintain consistency and quality, and the future scope of testing – including opportunities to improve access in resource-limited settings. Authors' opinions are their own and do not represent their institutions. Referenced papers include: Newborn screening in South Africa: the past, present, and plans for the future. Malherbe et al (2024) Clinical validation of cutoff target ranges in newborn screening of metabolic disorders by tandem mass spectrometry: a worldwide collaborative project. McHugh et al (2024) Five years of newborn screening for Pompe, Mucopolysaccharidosis type I, Gaucher, and Fabry diseases in Oregon. Viall & Held (2025) Long-term outcomes of adolescents and young adults identified by metabolic newborn screening. Mütze et al (2025) Treatment Outcomes for Maple Syrup Urine Disease Detected by Newborn Screening. Mengler et al (2024) Vitamin B12 Deficiency Newborn Screening. Mütze et al (2024) The role of exome sequencing in newborn screening for inborn errors of metabolism. Adhikari et al (2020)

Aiutaci a scaldare la speranza Al CRAS ci prendiamo cura ogni giorno di animali selvatici feriti o in difficoltà. Nei nostri container di degenza, accogliamo pazienti che hanno bisogno di un ambiente sicuro, tranquillo.

En été comme en vacances, il est très fréquent de faire une sieste pour combattre une vague de fatigue. Mais savez-vous à quoi elle est liée ? Les explications d'Emilie Steinbach.Hébergé par Audiomeans. Visitez audiomeans.fr/politique-de-confidentialite pour plus d'informations.

In this episode, Dr Joost Groen, a clinical biochemist at the University Medical Center Groningen, and Dr Matt Gentry, Professor & Chair of Biochemistry & Molecular Biology in the College of Medicine at University of Florida, join Rodrigo and Silvia to discuss new insights, AI, cancer metabolism and some of their favourite papers on Glycogen Storage Disorders. Authors opinions are their own and do not represent their institutions. GSD episode papers: Brain glycogen serves as a critical glucosamine cache required for protein glycosylation. Sun et al A machine learning model accurately identifies glycogen storage disease Ia patients based on plasma acylcarnitine profiles. Groen et al Small-molecule inhibition of glycogen synthase 1 for the treatment of Pompe disease and other glycogen storage disorders. Ullman et al Repurposing SGLT2 inhibitors: Treatment of renal proximal tubulopathy in Fanconi-Bickel syndrome with empagliflozin. Overduin et al Gross-Valle The relation between dietary polysaccharide intake and urinary excretion of tetraglucoside. Gross-Valle et al Glycogen drives tumour initiation and progression in lung adenocarcinoma. Clarke HA et al Spatial metabolomics reveals glycogen as an actionable target for pulmonary fibrosis. Conroy et al In situ mass spectrometry imaging reveals heterogeneous glycogen stores in human normal and cancerous tissues. Young et al Glycogen accumulation modulates life span in a mouse model of amyotrophic lateral sclerosis. Brewer et al Dynamics of cognitive variability with age and its genetic underpinning in NIHR BioResource Genes and Cognition cohort participants. Rahman MS et al Neurological glycogen storage diseases and emerging therapeutics Colpaert et al

Aujourd'hui, Jean-Loup Bonnamy, Bruno Poncet et Barbara Lefebvre débattent de l'actualité autour d'Alain Marschall et Olivier Truchot.

Tous les matins à 6h40, l'actualité du point de vue des auditeurs de RMC. Chaque jour, trois questions autour d'un sujet d'actualité. Témoignages, réactions et débats : RMC est LA radio de l'interactivité.

Featuring articles on routine cerebral embolic protection for TAVI, and treatments for cirrhosis due to MASH, BRAF V600E metastatic colorectal cancer, and Pompe's disease; a new review article series on medical education; a case report of a woman with dyspnea on exertion; and Perspectives on addressing ultraprocessed foods, on the costs of dismantling DEI, and on a brother's keeper.

durée : 00:03:26 - Un monde connecté - par : François Saltiel - Jeff Bezos, patron d'Amazon, pour son mariage, envisage trois jours de noces à Venise. Une fête qui suscite la colère des insulaires. Bien plus qu'un événement mondain, cette débauche de richesse est un symbole des tensions de classe et des problèmes environnementaux liés au tourisme de masse.

Aujourd'hui, Joëlle Dago-Serry, Antoine Diers et Didier Giraud débattent de l'actualité autour d'Alain Marschall et Olivier Truchot.

Après deux ans sans chauffage, Amélie rencontre un professionnel à la Foire de Châlons de 2021 pour remplacer sa pompe à chaleur. Elle règle 12.000€ en liquide et sans facture. Quelque temps plus tard, Amélie découvre que sa pompe à chaleur censée être neuve serait un modèle vétuste âgé de... 16 ans ! Aujourd'hui, après 4 hivers sans chauffage, et alors que l'équipement ne fonctionne toujours pas, Amélie vit dans l'angoisse du prochain hiver, sans solution fiable, ni chauffage fonctionnel. Dans le podcast « Ça peut vous arriver » sur RTL, Julien Courbet et son équipe distribuent conseils conso et astuces juridiques pour lutter contre les arnaques dans la bonne humeur. Ecoutez Ça peut vous arriver avec Julien Courbet du 23 juin 2025.Distribué par Audiomeans. Visitez audiomeans.fr/politique-de-confidentialite pour plus d'informations.

Aujourd'hui dans "Punchline", Laurence Ferrari et ses invités débattent du risque de l'augmentation du prix du carburant au vu de l'escalade entre Israël et l'Iran.Distribué par Audiomeans. Visitez audiomeans.fr/politique-de-confidentialite pour plus d'informations.

It is not trite to say that some people see challenges as obstacles and others see them as opportunities. Katy Arvidson was ten years old when she was diagnosed with Pompe disease. In spite of that diagnosis, she kept going and eventually obtained her Master's Degree in Social Work. Katy is currently Ms. Wheelchair Alaska, embracing a platform of not just surviving but thriving. She talks about her life, work, and dedication to helping people. Katy can be supported and reached through The Dane Foundation, whose mission is to provide for the unique needs of individuals with physical and developmental disabilities: http://thedanefoundation.org/donate.html More information about the Ms. Wheelchair USA competition can be found at: https://www.mswheelchairusa.org/ The views and opinions of the guests on this podcast are theirs and theirs alone and do not necessarily represent those of the host, Westwords Consulting or the Kenosha County Substance Abuse Coalition. We're always interested in hearing from individuals or organizations who are working in substance use disorder treatment or prevention, mental health care and other spaces that lift up communities. This includes people living those experiences. If you or someone you know has a story to share or an interesting approach to care, contact us today! Follow us on Facebook, LinkedIn, and YouTube. Subscribe to Our Email List to get new episodes in your inbox every week!

Retrouvez Alexandre Le Mer chaque jour pour un échange exclusif avec un invité sur un sujet d'actualité majeur. En quelques minutes, obtenez un éclairage précis et pertinent pour mieux comprendre les enjeux du moment. Un rendez-vous incontournable pour démarrer la journée informé, avec des analyses percutantes et des points de vue d'expertsDistribué par Audiomeans. Visitez audiomeans.fr/politique-de-confidentialite pour plus d'informations.

La FDA (Food and Drug Administration) a émis son alerte de niveau le plus élevé concernant une pompe cardiaque qui a été liée à 49 décès et 129 blessures.Traduction :FDA has issued its highest-level alert about a heart pump that has been linked to 49 deaths and 129 injuries. Hosted on Acast. See acast.com/privacy for more information.

La FDA (Food and Drug Administration) a émis son alerte de niveau le plus élevé concernant une pompe cardiaque qui a été liée à 49 décès et 129 blessures.Traduction :FDA has issued its highest-level alert about a heart pump that has been linked to 49 deaths and 129 injuries. Hosted on Acast. See acast.com/privacy for more information.

Toeriste wat in die Etosha Nasionale Park reis kla oor 'n gebrek aan beide petrol en diesel, veral by Namutoni en Okaukuejo. Volgens berigte was daar die afgelope vyf of ses dae min tot geen brandstof beskikbaar nie. Kosmos 94.1 Nuus het gesels met Nelson Ashipala, Namibia Wildlife Resorts se woordvoerder, wat die situasie bevestig en meer inligting oor ander geraakte gebiede gee.

Glucose is the main source of energy for all forms of life, but it isn't usually stored as individual C6H12O6 molecules. Animals use glycogen to do that job. Glycogen is a large branched polymer of glucose molecules, linked together by α-1,4 and α-1,6 glycosidic bonds. The liver and muscles break down the stored glycogen whenever the body needs an extra boost of glucose. Glycogen storage diseases are genetic defects in glycogen metabolism resulting in accumulation of glycogen. What happens when macromolecules accumulate in cells? Cell damage and dysfunction. Because the liver and muscles are the two main organs that use glycogen, they are also the two most affected by glycogen storage diseases. In the liver, glycogen accumulation leads to hypoglycemia since the glycogen can't be broken down to glucose. Damage to the liver from extra glycogen can also lead to liver failure or even liver cancers. In the muscles, glycogen accumulation causes weakness, exercise intolerance, and potentially heart failure. There are at least 12 distinct glycogen storage diseases, but we'll cover only the 4 most common ones. After listening to this Audio Brick, you should be able to: Identify the most common glycogen storage diseases: von Gierke disease (type 1), Pompe disease (type 2), Cori disease (type 3), and McArdle disease (type 5). Identify the enzymes deficient in each of the most common glycogen storage diseases. Describe the clinical manifestations of each of the most common glycogen storage diseases. Describe management for each of the most common glycogen storage diseases. You can also check out the original brick from our Cellular and Molecular Biology collection, which is available for free. Learn more about Rx Bricks by signing up for a free USMLE-Rx account: www.usmle-rx.com You will get 5 days of full access to our Rx360+ program, including nearly 800 Rx Bricks.  After the 5-day period, you will still be able to access over 150 free bricks, including the entire collections for General Microbiology and Cellular and Molecular Biology. *** If you enjoyed this episode, we'd love for you to leave a review on Apple Podcasts.  It helps with our visibility, and the more med students (or future med students) listen to the podcast, the more we can provide to the future physicians of the world. Follow USMLE-Rx at: Facebook: www.facebook.com/usmlerx Blog: www.firstaidteam.com Twitter: https://twitter.com/firstaidteam Instagram: https://www.instagram.com/firstaidteam/ YouTube: www.youtube.com/USMLERX Learn how you can access over 150 of our bricks for FREE: https://usmlerx.wpengine.com/free-bricks/ from our Musculoskeletal, Skin, and Connective Tissue collection, which is available for free. Learn more about Rx Bricks by signing up for a free USMLE-Rx account: www.usmle-rx.com You will get 5 days of full access to our Rx360+ program, including nearly 800 Rx Bricks.  After the 5-day period, you will still be able to access over 150 free bricks, including the entire collections for General Microbiology and Cellular and Molecular Biology.

Mardi 18 février, François Sorel a reçu Julien Villeret, directeur de l'innovation chez EDF, Claudia Cohen, journaliste chez Bloomberg, et Taïg Khris, fondateur d'OnOff et d'Albums. Ils se sont penchés sur le dévoilement de Grok 3 par Elon Musk, le lancement de Deep Research, un rival gratuit à OpenAI par Perplexity, et la préparation de Huawei pour son retour sur le plan international, dans l'émission Tech & Co, la quotidienne, sur BFM Business. Retrouvez l'émission du lundi au jeudi et réécoutez-la en podcast.

Een nieuwe #nerdland podcast! Met deze maand: Tasmaanse Tijgers! Everest & xenon! Deepseek! Stargate! De piSSStream! Pompeï! En veel meer... Shownotes: https://podcast.nerdland.be/nerdland-maandoverzicht-februari-2025/ Gepresenteerd door Lieven Scheire, met Kurt Beheydt, Marian Verhelst, Peter Berx, Bart Van Peer en Toon Verlinden. Montage & mastering door Jens Paeyeneers. (00:00:00) Intro (00:02:11) Els en Hetty hebben een baby! En de baby is mooi! En hij heet Max! (00:03:45) Lieven ging op space reis! (00:11:48) Can we use quantum computers to test radical consciousness theory? (00:25:17) Stapje dichter bij levende Tasmaanse tijger (00:37:36) Kan je de Everest beklimmen in 3 dagen met Xenon? (00:44:49) CES beurs gadgets (00:52:48) AI NIEUWS (00:53:10) DeepSeek R1 open source LLM uit China (01:03:30) Er is een LEGO ASML machine! (01:08:11) OpenAI lanceert “operator” (01:11:44) Nieuwste OpenAI toepassing kan 1000 dollar per search kosten (01:13:44) AI-wetenschapper: Sakana.ai (01:17:54) Stargate plan van 500 miljard in USA (01:18:55) Studenten gebruiken NotebookLM (01:21:20) Momenteel planetenparade te zien (01:25:09) SILICON VALLEY NEWS (01:25:29) New Glenn test launch (01:28:17) Starship 7 test launch (01:32:26) Musk moeit zich met Artemis (01:34:22) Space X lanceert twee onbemande maanmissies (01:36:35) pISSStream toont hoeveel pies er in het ISS zit. (01:43:00) De lente begint onder de grond (01:48:57) VLC automatische ondertiteling (01:56:10) Grootste prive-badhuis ooit ontdekt in Pompei (02:03:56) Vluchtende voeten ontdekt bij Vesuvius (02:12:11) Duidelijk verschillen tussen hersenen pasgeboren jongens en meisjes (02:26:20) Tsjechische onderzoekers vinden nieuwe diersoort… in de huisdierenwinkel! (02:30:33) What eats Dubas bugs? (02:35:44) Meteoriet valt voor voordeur (02:40:09) Eindelijk duidelijk waarom klap op het hoofd dementierisico verhoogt (02:44:42) RECALLS / MEDEDELINGEN (02:44:46) Ingestuurde Kwatrijnen (02:47:01) Puntjes op de i: Trump zei niet dat wie een biljoen investeert zomaar vergunning krijgt, wel dat ze die versneld zullen krijgen. (02:48:18) Coolest Projects is dit jaar op 26 april, inschrijven via coolestprojects.be (02:49:43) Dwengo geeft robotkits weg. (02:51:39) EIGEN PROMO (02:51:46) Lieven AI tour: s Hertoghenbosch op 6 feb, Norwich (UK) op 18 feb, in Arnhem op 5 maart, Amsterdam op 7 maart, ook op VTM Go (02:52:13) Hetty toert nog tot april: hettyhelsmoortel.be (02:52:30) Toon: code Rood, Maarten, boek: bier, ook brouwpakket weer beschikbaar (02:53:25) SPONSOR: Planet B

In this inspiring episode of PH Journals Beyond the Camo, I sit down with Bruce Campbell—an endurance coach, Ironman athlete, and someone who refuses to let Pompe Disease define his limits. Bruce has been a massive influence on my 70.3 Ironman journey, not only pushing me physically but also shaping my mindset and mental resilience. We dive into: ✅ His journey with Pompe Disease and how it changed his life ✅ The challenges of living with a progressive condition ✅ How he approaches coaching and mentorship in endurance sports ✅ The importance of mental resilience in Ironman training ✅ His personal philosophies on overcoming obstacles ✅ Advice for aspiring endurance athletes Bruce's story is a testament to the power of determination and the mindset it takes to keep pushing forward, no matter the odds. Whether you're an athlete, someone facing personal challenges, or just looking for inspiration, this episode is a must-watch!

In this inspiring episode of PH Journals Beyond the Camo, I sit down with Bruce Campbell—an endurance coach, Ironman athlete, and someone who refuses to let Pompe Disease define his limits. Bruce has been a massive influence on my 70.3 Ironman journey, not only pushing me physically but also shaping my mindset and mental resilience. We dive into: ✅ His journey with Pompe Disease and how it changed his life ✅ The challenges of living with a progressive condition ✅ How he approaches coaching and mentorship in endurance sports ✅ The importance of mental resilience in Ironman training ✅ His personal philosophies on overcoming obstacles ✅ Advice for aspiring endurance athletes Bruce's story is a testament to the power of determination and the mindset it takes to keep pushing forward, no matter the odds. Whether you're an athlete, someone facing personal challenges, or just looking for inspiration, this episode is a must-watch!

Karina vous dévoile les décisions de justice les plus improbables.

durée : 00:05:14 - Avec sciences - par : Alexandre Morales - Comment augmenter la l'efficacité de la captation du carbone par les océans ? Selon des chercheurs de l'université de Dartmouth, la solution se trouverait dans l'ajout de poussière à la surface des océans. Mais la méthode peut-elle (et doit-elle) être appliquée à large échelle ?

durée : 00:02:36 - L'Humeur du matin par Guillaume Erner - par : Guillaume Erner - Je vais vous faire une confidence : sur France Culture, on ne déteste pas la théorie et les explications complexes. Parmi les motivations de vote, il y a des mécanismes inconscients, ou méta-conscients pour ceux qui n'aiment pas les théories de l'inconscient. - réalisation : Félicie Faugère

1/2:Réenchanter les funérailles Alors que nous mourrons de plus en plus à l'hôpital ou à l'EHPAD, que les pompes funèbres sont devenues un marché gigantesque à qui nous déléguons des gestes importants auprès de nos défunts, de nombreuses femmes réfléchissent à se réapproprier la mort et les funérailles, collectivement. Comme les féministes ont pu le faire pour les naissances, elles parlent de revaloriser le travail de soin, la nécessité de respecter les corps et la temporalité propre à ces moments intimes et fragiles. Veillées à domicile, toilettes mortuaires, cérémonies, elles souhaitent réenchanter la mort.Comment retrouver des rituels, et le temps nécessaire pour vivre des funérailles à nos images, c'est la question que pose ce premier épisode d'une série de deux autour de la mort. Avec :Hélène Chaudeau, accompagnante funéraireKate Houben, accompagnante funéraireJuliette Cazes, autriceAlexa Hagerty, anthropologueLisa Carayon, juriste Textes :Sortir au jour, Amandine DhéeLa femme-qui-aide et la laveuse, Yvonne VerdierLa laveuse de mort, Sara OmarSpiritualités radicales, Yuna VisantinLa cendre de tes morts, Albertine Delanpe RemerciementsMerci à Martin Julien Coste, Marion Waller, Virginie Chavance. Pour prolonger l'écoute- Collectif Par la racine ;- Pionnières du monde funéraire ;- Anthropologie et mort ;- Au bonheur des morts, Vincianne Despret ;- Le travail des morts, Thomas Laqueur ;- Réenchanter la mort, Youki Vattier ;- Coopérative funéraire de Rennes ;- Coopérative funéraire de Lyon ;- Coopérative funéraire de Bordeaux ;- Pompe funèbre Noir Clair à Lyon ;- Thanatosphere ;- Noémie Robert, célébrante funéraire ;- Association d'entre aide à la fin de vie et au deuil ;- Podcast Mortel par Taous Merakchi ;- Le bizarreum ;- Happy end ;- Collectif pour une Sécurité sociale de la mort ;- Mémé Radio Enregistrements : octobre 2024 - Prise de son, montage, textes et voix : Charlotte Bienaimé - Réalisation et mixage : Charlie Marcelet - Accompagnement réalisation : Gary Salin - Lectures : Estelle Clément Béalem - Accompagnement éditorial : Sarah Bénichou - Illustrations : Anna Wanda Gogusey

1/2:Réenchanter les funérailles Alors que nous mourrons de plus en plus à l'hôpital ou à l'EHPAD, que les pompes funèbres sont devenues un marché gigantesque à qui nous déléguons des gestes importants auprès de nos défunts, de nombreuses femmes réfléchissent à se réapproprier la mort et les funérailles, collectivement. Comme les féministes ont pu le faire pour les naissances, elles parlent de revaloriser le travail de soin, la nécessité de respecter les corps et la temporalité propre à ces moments intimes et fragiles. Veillées à domicile, toilettes mortuaires, cérémonies, elles souhaitent réenchanter la mort.Comment retrouver des rituels, et le temps nécessaire pour vivre des funérailles à nos images, c'est la question que pose ce premier épisode d'une série de deux autour de la mort.Avec :Hélène Chaudeau, accompagnante funéraireKate Houben, accompagnante funéraireJuliette Cazes, autriceAlexa Hagerty, anthropologueLisa Carayon, juristeTextes :Sortir au jour, Amandine DhéeLa femme-qui-aide et la laveuse, Yvonne VerdierLa laveuse de mort, Sara OmarSpiritualités radicales, Yuna VisantinLa cendre de tes morts, Albertine DelanpeRemerciementsMerci à Martin Julier-Costes, Marion Waller, Virginie Chavance.Pour prolonger l'écoute- Collectif Par la racine ;- Pionnières du monde funéraire ; Juliette Cazes- Anthropologie et mort ;- Au bonheur des morts, Vincianne Despret ;- Le travail des morts, Thomas Laqueur ;- Réenchanter la mort, Youki Vattier ;- Coopérative funéraire de Rennes ;- Coopérative funéraire de Lyon ;- Coopérative funéraire de Bordeaux ;- Pompe funèbre Noir Clair à Lyon ;- Thanatosphere ;- Noémie Robert, célébrante funéraire ;- Association d'entre aide à la fin de vie et au deuil ;- Podcast Mortel par Taous Merakchi ;- Le bizarreum ;- Happy end ;- Collectif pour une Sécurité sociale de la mort ;- Mémé Radio Enregistrements octobre 2024 Prise de son, montage, textes et voix Charlotte Bienaimé Réalisation et mixage Charlie Marcelet Accompagnement réalisation Gary Salin Lectures Estelle Clément Béalem Accompagnement éditorial Sarah Bénichou Illustrations Anna Wanda Gogusey

Acest episod al podcastului îl are ca invitat pe Ovidiu Țifui, poate cel mai bun inginer de instalații din România. Într-o discuție amânată de prea mult timp, vorbim despre eficiența energetică și avantajele instalării pompelor de căldură față de centralele pe gaz. Ovidiu a explicat avantajele pompelor de căldură sol-apă și aer-apă și cum acestea pot asigura atât încălzirea, cât și răcirea eficientă a locuinței. Pentru mine, cel mai important a fost subiectul calității aerului interior și exterior, importanța ventilației corespunzătoare și folosirea filtrelor pentru a menține un mediu sănătos. Episodul oferă informații valoroase pentru cei interesați de eficiență energetică, sustenabilitate și soluții moderne de încălzire și răcire.IGDLCC înseamnă Informații Gratis despre Lucruri care Costă! Totul ne costă dar mai ales timpul așa că am făcut această serie pentru a mă informa și educa alături de invitați din domeniile mele de interes. Te invit alături de mine în această călătorie. Mi-am propus să mă facă mai informat și mai adaptat la schimbările care vin. Sper să o facă și pentru tine.

Une plateforme qui condense le pire des dérives en matière de cryptomonnaies fait le buzz, avec son apogée proposant des diffusions de vidéos en live peu recommandables. Tant pis Tendance Participants