Podcasts about Amplitude

In this episode, Justin Bauer, former Chief Product Officer at Amplitude and now one of the most sought-after product advisors in AI, talks about the pivotal career moments that shaped his leadership style. From betting everything on a tiny startup with 13 people to navigating layoffs and leveling conversations, Justin shares how he learned to lead with clarity, humility, and courage.He also reflects on what it takes to thrive in a high-growth environment — and how to reinvent yourself every 18 months to stay relevant. This is a conversation about ambition, emotional resilience, and how to earn trust when the stakes are high.In this conversation, you'll learn:Why preparation and self-reflection are Justin's keys to confident leadershipHow to navigate the emotional toll of layoffs, leveling, and managing upWhy clarity of expectations keeps your career evolvingThings to listen for:(00:00) Intro(01:44) Justin's early life in Iowa(04:33) First jobs and early ambitions(07:39) Thanks to our sponsor, Navattic & ThriveStack(10:47) A high-stakes decision to join Amplitude(14:00) The reality of startup life(16:00) Advice for aspiring startup employees(18:55) Feedback and career growth(26:41) Overcoming imposter syndrome(27:11) Navigating leadership challenges(29:16) Seeking clarity in a growing company(30:52) Managing up and building relationships(37:50) Handling layoffs and difficult conversations(43:06) The importance of preparation and role-playing(56:05) The value of deep thinking timeThis episode is presented by:Navattic: Interactive Product Demo Software - https://navattic.com/value ThriveStack: Measure Growth. Find Drivers. Fix Leaks. https://www.thrivestack.ai/Resources:Connect with Justin:LinkedIn: https://www.linkedin.com/in/jjbauer/ Connect with Andrew:LinkedIn: https://www.linkedin.com/in/andrewcapland/ Substack: https://media.deliveringvalue.coHire Andrew as your coach: https://deliveringvalue.co/coaching

Thompson and Austin Hay, co-founders of Clarify, the startup that's pioneering the idea of autonomous CRM. Their vision? A CRM that actually does the work for sellers of driving outreach, managing pipeline, and surfacing insights without constant manual input. Patrick and Austin share: • Their journey from Iteratively, Ramp, and Amplitude to founding Clarify • Why the CRM market is ripe for disruption with AI • How Clarify's unique pricing model flips the script (free CRM, pay only when the AI agent works for you) • The concept of autonomous GTM teams and the rise of the Go-to-Market Engineer • Lessons in building culture, hiring talent, and embracing the “beautiful mess” of startups If you're a founder, sales leader, or builder rethinking your revenue stack and curious about how AI will transform the way teams sell, this conversation is a must-listen.

Engineering leadership is undergoing a seismic shift, requiring playbooks to be rewritten, in real-time. In this special episode, hosts Patrick Gallagher and Jerry Li give you an inside look at the ELC Annual 2025 experience, and how the two-day conference will equip you with new mental models, skills, and frameworks required to lead.Get a preview of tactical takeaways from deep operational dives into companies like OpenAI, Amplitude, and HeyGen. Discover how the conference will help you redesign your innovation engine, transform your team's workflows, and blur the lines between engineering, product, and business to drive impactful change. Through a unique mix of tactical sessions, peer-led roundtables, and curated mentorship, you'll learn how to find the community and coaching needed to lead through uncertainty and invest in your own career growth.To learn more & get tickets, go to sfelc.com/annual2025Use code podcast15 for 15% off tickets - group tickets / discounts available. ABOUT ELC ANNUALThe playbook for engineering leadership is being rewritten. ELC Annual 2025, happening September 10-11 in San Francisco, is where you'll gain the insights, strategies, and deep connections needed to lead in this new era. 50+ speakers, 50+ peer-led roundtables discussions, 1:1 matching to expand your network. Insights, connections & support.Join the community of engineering leaders who are co-creating the future of our field.Listener Discount → Use code podcast15 for 15% offGroup Tix → For teams looking to attend together, special group discounts can be found under the 'Tickets' section of our website!Secure your ticket at sfelc.com/annual2025 ToolHive Unlocks the Full Value of MCP & Your AI AgentsSo you've invested in AI agents for code generation, but they're limited to experiments or even stuck on the shelf. To do real, valuable work, those AI agents need access to your data and systems.ToolHive helps you confidently connect the pieces by making it simple and secure for you to use the Model Context Protocol (MCP).ToolHive includes a pre-vetted registry of MCP servers, containerizes every MCP server for consistency and leans on built-in security to keep your secrets safe.Leaders trust ToolHive to put MCP into production and put their AI agents to work.ToolHive is open source, so get started for free at toolhive.dev Join us at ELC Annual 2025ELC Annual is the premier event for engineering leaders. This is our biggest event of the year: 1,000+ CTOs, VPs & Directors in San Francisco @ ELC Annual 2025 for two days of leadership breakthroughs, tactical peer learning & curated connections!

In this episode of The Option Block, the host Mark Longo, along with guests Henry "The FlowMaster" Schwartz from Cboe and "Uncle" Mike Tosaw from St. Charles Wealth Management, delve into current market dynamics influenced by inflation data, Fed rate cuts, and significant movements in stocks like Apple, AMD, and Nvidia. They also explore unusual options activity in stocks like Equinox Gold and Amplitude, revealing intriguing trading strategies and market sentiments. The discussion includes the implications of upcoming geopolitical summits and the ongoing earnings season. The episode wraps up with listener questions on trading strategies and a nostalgic look back at 80s movies such as Rocky IV.   01:05 Meet the Hosts and Show Overview 03:17 Market Analysis and Trading Insights 05:24 Volatility and Market Trends 08:44 Individual Stocks and Market Movers 29:02 Earnings Season Highlights 30:14 Cisco's Market Reaction 30:34 Applied Materials Earnings Preview 31:03 Upcoming Retail Earnings: Target and Walmart 31:39 Seasonal Trading Insights 32:29 Odd Block: Unusual Options Activity 33:15 Equinox Gold Corp Analysis 40:59 Unity Software: Big Call Buyers 44:30 Mail Block: Listener Questions 44:58 Rocky IV and 80s Nostalgia 46:43 Earnings Poll and Market Sentiment 51:44 Around the Block: Market Watch 54:45 Show Wrap-Up and Upcoming Content  

Ken Sluiter is a Grammy‑nominated recording engineer, producer, and mixer whose career spans from Chicago's indie scene to major Los Angeles studios. He has worked with a diverse roster of artists, including Weezer (Red Album), Morrissey, James Blunt, Heart, OK Go, Jerry Lee Lewis, Andra Day, The Mekons, and Flogging Molly. After establishing himself at Chicago's Kingsize Sound Labs, Ken moved to LA in 2003, where he assisted legendary engineers Andrew Scheps, Greg Fidelman, and Jim Scott on projects for artists such as Metallica, Pink, and Keith Richards.Known for his refined in‑the‑box Pro Tools workflow and ability to commit to bold sonic decisions early in the process, Ken blends analog tracking with digital precision in his own API‑equipped mix room. His credits extend to film and television scores—including Hannibal and American Gods—and he now works extensively in Dolby Atmos, continuing to shape mixes for artists across genres.IN THIS EPISODE YOU'LL LEARN:Working on jinglesThe process of editing on tapeCharging based on time vs per projectChecking your ego at the door to help grow your careerAlways being ready for anything to happen in the studioBeing flexible to a band's style of workingHow clocking affects your sound while mixingHow to identify a good clock from a bad oneMixing in-the-box vs. hybridWhy you should listen really loud when starting a mixListening in context to determine when something is/isn't a problemMaking bass sound good on small speakersFocusing on mixing translationMixing kick drums to feel big, but without being muddyUsing gates as a sound shaperKick/bass relationships: How to get them to work well togetherTo learn more about Ken Sluiter, visit: https://promixacademy.com/mentor/ken-sluiter/Looking for 1-on-1 feedback and training to help you create pro-quality mixes?Check out my coaching program Amplitude and apply to join:https://masteryourmix.com/amplitude/ Want additional help with your music productions?For tips on how to improve your mixes, visit: https://masteryourmix.com/ Download your FREE copy of the Ultimate Mixing Blueprint: https://masteryourmix.com/blueprint/ Get your copy of my Amazon #1 bestselling books:The Recording Mindset: A Step-By-Step Guide to Creating Pro Recordings From Your Home Studio: https://therecordingmindset.com The Mixing Mindset: The Step-By-Step Formula For Creating Professional Rock Mixes From Your Home Studio: https://masteryourmix.com/mixingmindsetbook/ Check out our Sponsors:Download Waves Plugins here: https://waves.alzt.net/EK3G2K Subscribe to the show:Apple Podcasts: https://podcasts.apple.com/us/podcast/master-your-mix-podcast/id1240842781 Spotify: https://open.spotify.com/show/5V4xtrWSnpA5e9L67QcJej Youtube: http://www.youtube.com/@MasterYourMix...

Your hard-earned leadership skills may not be enoughWhen I sat down with Thomas Hansen — President of Amplitude, and former executive at Microsoft and Dropbox — I knew this conversation would change the way I think about leadership.Thomas has led billion-dollar teams, navigated career reinventions, and even learned leadership lessons on a windsurfing board. In this episode, he opens up about the next leadership superpower every leader needs to survive — and thrive — in today's AI-driven world.You'll discover:- Why the “career ladder” is gone for good.- The daily habit he uses to stay ahead with his team.- How AI is shifting what makes a great leader.- Why the best CEOs embrace what they don't know.- What windsurfing taught him about business risk and resilience.This isn't theory — it's real, hard-won insight from the front lines of leadership. If you're a CEO, President, Founder, or rising leader, these are the strategies that will keep you in the game when everything around you is changing.-----Follow Thomas on LinkedIn: https://www.linkedin.com/in/thomasneergaardhansen/Learn more about Amplitude: https://amplitude.com/-----Connect with the Host, #1 bestselling author Ben FanningSpeaking and Training inquiresSubscribe to my Youtube channelLinkedInInstagramTwitter

AI is transforming marketing — making alignment between product, marketing, and sales more critical than ever. In this episode of Talking Too Loud, Amplitude CMO Tifenn Dano Kwan shares how she bridges team cultures, drives trust, and uses deadlines to turn the GTM tug-of-war into growth.Links to Learn More:Follow Tifenn Dano Kwan on LinkedInFollow Savage on LinkedInSubscribe to Talking Too Loud on WistiaWatch on YouTubeFollow Talking Too Loud on InstagramFollow Talking Too Loud on TikTokLove what you heard? Leave us a review!On AppleOn Spotify

All links and images can be found on CISO Series. Check out this post for the discussion that is the basis of our conversation on this week's episode co-hosted by me, David Spark, the producer of CISO Series, and Steve Zalewski. Joining them is Terry O'Daniel, former CISO at Amplitude. In this episode:  Beyond prioritization: aligning risk with reality From signals to strategy The Case for Maturity Models Security Starts With Culture Huge thanks to our sponsor, SecurityPal SecurityPal is the leader in Customer Assurance, helping companies accelerate security assurance without compromising accuracy. Their AI + human expertise approach, dynamic Trust Center, and modern TPRM solution eliminate manual work and streamline vendor security at scale. To learn more, visit securitypal.ai.

Steve Chadie, a 25+ year veteran of the recording industry, began his career as an intern at Willie Nelson's Pedernales recording studio in 1995, quickly working his way up to Assistant Engineer for Larry Greenhill.He stayed on at Pedernales until the doors closed commercially in 2012. He still records Willie Nelson at the facility, however, including vocals and guitar on “Last Man Standing”, “My Way” (for which he received a Grammy for Best Traditional Pop Vocal Album), “God's Problem Child”, “Willie Nelson and The Boys”, and “Summertime -Willie Nelson sings Gershwin”.Most recently, Steve co-produced “The Willie Nelson Family”, a collection of songs done with his band in March 2019 and with his immediate family at the beginning of the pandemic in April 2020.Other credits with Willie include tracking engineer on "Heroes”, "Let's Face The Music And Dance”, “Django And Jimmie” (Willie's collaboration with Merle Haggard in 2015) and mixing on "December Day", a collection of work he recorded with Willie and his sister Bobbie in between touring on impromptu sessions that date as far back as 2004.Steve has been awarded a double platinum record for Los Lonely Boys "Heaven" and was nominated for a Grammy for the song "Heaven", as well. He has recorded and/or mixed five Los Lonely Boys records since their debut release.Other accolades include a triple platinum record for work done on Sublime's "Sublime" and a platinum record for work on Hillary Duff's self-titled recording "Hillary Duff". In addition, he has been awarded a gold record for work done on Kenny Wayne Shepherd's "Live On" CD.IN THIS EPISODE YOU'LL LEARN:Working with Willie NelsonBeing reliableHow to get artists to keep hiring youWhy you should always be “rolling” when in the studioRiding vocals as you record themRecording brushes on a drum kitHow to record acoustic guitarsMono vs stereo recording techniques on guitars: When and where to use themSteve's technique for creating wide-sounding acoustic guitarsExperimenting in the studio without slowing down a session To learn more about Steve Chadie visit: https://stevechadie.com/Looking for 1-on-1 feedback and training to help you create pro-quality mixes?Check out my coaching program Amplitude and apply to join:https://masteryourmix.com/amplitude/ Want additional help with your music productions?For tips on how to improve your mixes, visit: https://masteryourmix.com/ Download your FREE copy of the Ultimate Mixing Blueprint: https://masteryourmix.com/blueprint/ Get your copy of my Amazon #1 bestselling books:The Recording Mindset: A Step-By-Step Guide to Creating Pro Recordings From Your Home Studio: https://therecordingmindset.com The Mixing Mindset: The Step-By-Step Formula For Creating Professional Rock Mixes From Your Home Studio: https://masteryourmix.com/mixingmindsetbook/ Check out our Sponsors:Download Waves Plugins here: https://waves.alzt.net/EK3G2K Subscribe to the show:Apple Podcasts:

Andrew Casey remembers a moment when colleagues truly looked to him for leadership. At ServiceNow, a then‑$400 million company with little go‑to‑market infrastructure, the team faced a long list of missing elements: no functioning comp plan, no partner ecosystem, and no clear strategy for scaling sales. “Whenever people said they didn't know how,” Casey recalls, “I started raising my hand and said, I don't know either, but I know what we're going to go do… and then we're going to adjust as we go.” That willingness to lead through uncertainty became a turning point in his career.ServiceNow would grow from $400 million to $4.5 billion during his tenure, and colleagues still use the pricing and deal frameworks he created, he tells us. The experience cemented his approach: chase experiences, not titles, and transform finance into a partner that drives business outcomes.That mindset carried into his first CFO role at WalkMe in 2020, where, just two weeks in, COVID forced an immediate office shutdown. “We didn't even have a work‑from‑home policy,” he tells us. The sudden disruption forced him to navigate crisis management, team alignment, and IPO preparation simultaneously.His journey through Sun Microsystems, Symantec, Oracle, HP, ServiceNow, and Lacework sharpened his ability to guide transformation and scale. Today, as CFO of Amplitude, Casey draws on those lessons to help a smaller public company grow with discipline. Each chapter—from orchestrating 37 acquisitions at Oracle to steering turnarounds—reflects a career built on stepping into complexity, listening first, and leading change with confidence.

Too often, product managers work as human middleware between data sources and stakeholders, drowning in analysis instead of making strategic decisions that move the needle. Life is short—you need to get your time back. In this episode, Ross Webb (who built data-driven products generating £50M+ revenue) explores how AI transforms decision-making by automatically analysing customer feedback from every source and synthesising actionable insights whilst you focus on strategy. What You'll Learn: Why extraordinary curiosity is the most important product management skill (and how AI amplifies it)How to adapt frameworks to serve your business instead of constraining itWhy field experience with customers beats desk research every single timeThe customer-obsessed mindset that separates experience leaders from feature buildersHow AI can automate customer feedback analysis and data synthesis from multiple sources Featured Guests: Christoph Bodenstein - Data literacy expert on curiosity-driven analysis and AI transformationHarris Kaldis - Framework adaptation specialist on flexible processes and strategic communicationMichael Cooper - Customer intelligence expert on field experience and direct customer connectionAlba Simon - Customer experience specialist on friction elimination and consumer empathyJoão Moreira - Startup strategy expert on balancing agility with structured product thinking Key Takeaways: The future belongs to PMs who combine AI-powered data processing with deep customer empathyFrameworks should be tools that serve you, not rules that constrain strategic thinkingDaily customer contact should be non-negotiable for any serious product managerAI can handle the heavy lifting of data synthesis, freeing PMs for strategic insight and action Sponsored by FlowFocus AI - The agentic AI system that connects your entire product stack (Jira, Amplitude, PostHog, roadmapping tools, competitive intelligence) and saves product managers 5-10 hours per week. Because life is too short to be human middleware.

Taylor Larson is a record producer, mixer, and audio engineer who has worked with artists such as Asking Alexandria, Periphery, From First to Last, I See Stars, Veil of Maya, Within Temptation, The Dangerous Summer, Conditions, and Sky Eats Airplane. He is also the guitarist of The Evening.IN THIS EPISODE YOU'LL LEARN:Making sacrifices to work in audioUsing reference tracks to make you a better engineerHow to create energy in a mixRecording drums that hit hardThe secret tip John Feldmann uses for recording drums that sound bigBreaking the “rules” of audioCreating sustain for your drumsA simple trick for getting ghost notes to be clearly heardWhy dynamics aren't always importantTo learn more about Taylor Larson's company, MixWave, visit: https://www.mixwave.net/Looking for 1-on-1 feedback and training to help you create pro-quality mixes?Check out my coaching program Amplitude and apply to join:https://masteryourmix.com/amplitude/ Want additional help with your music productions?For tips on how to improve your mixes, visit: https://masteryourmix.com/ Download your FREE copy of the Ultimate Mixing Blueprint: https://masteryourmix.com/blueprint/ Get your copy of my Amazon #1 bestselling books:The Recording Mindset: A Step-By-Step Guide to Creating Pro Recordings From Your Home Studio: https://therecordingmindset.com The Mixing Mindset: The Step-By-Step Formula For Creating Professional Rock Mixes From Your Home Studio: https://masteryourmix.com/mixingmindsetbook/ Check out our Sponsors:Download Waves Plugins here: https://waves.alzt.net/EK3G2K Subscribe to the show:Apple Podcasts: https://podcasts.apple.com/us/podcast/master-your-mix-podcast/id1240842781 Spotify: https://open.spotify.com/show/5V4xtrWSnpA5e9L67QcJej Youtube: http://www.youtube.com/@MasterYourMix Have questions you'd like answered on the show?Send them to questions@masteryourmix.comPlease leave a rating and review:https://masteryourmix.com/review/ Thanks for listening!

Elena Verna is a renowned growth advisor to tech startups, and currently heads Growth at Lovable, one of the fastest growing tech startups globally -- where she helped the AI-native company reach $80M ARR in under seven months with a lean team. Previously, she held senior roles at world leading technology companies such as SurveyMonkey, Miro, Amplitude, and Dropbox, and has advised companies like MongoDB, Superhuman, and Veed. +++ To support this podcast, check out our some of our sponsors & get discounts:→ $1,000 off Vanta: Your compliance superpower — vanta.com/high→ Get up to 6 months of Notion's Business plan for free with Notion AI included (worth $12K): Go to - https://ntn.so/highflyers & click “Apply Now”If you're keen to discuss sponsorship and partnering with us or recommend future guests, email us at contact@curiositycentre.com today! Join our stable of commercial partners including the Australian Government, Google, KPMG, University of Melbourne and more.  ***CLICK HERE to read show notes from this conversation. Please enjoy!***Follow us on Instagram, LinkedIn or TwitterGet in touch with our Founder and Host, Vidit Agarwal directly hereContact us via our website to discuss sponsorship opportunities, recommend future guests or share feedback, we love hearing how to improve! Thank you for rating / reviewing this podcast on Apple Podcasts and Spotify, it helps others find us and convince guests to come on the show! ***The High Flyers Podcast is described as a "meticulously researched biography" that uncovers the untold stories of remarkable people and companies -- redefining the "high flyer". Launched in 2020, we have ranked in the global top ten podcasts for past two years, with listeners in 27 countries and over 200 episodes released. Excerpts of the podcast have been featured in Forbes, AFR, Daily Telegraph, and showcased at SXSW.200+ guests have joined host, Vidit Agarwal on the show from 15+ countries, including The CEO's of multi-billion dollar companies like Bunnings, Australia Post, Woolworths, Airwallex, Eucalyptus etc; Board Members at Macquarie Bank, ANZ, Reserve Bank etc; Former Prime Minister of Australia; Globally renowned Tech CEO's from Google, Microsoft, Xero etc, Successful Venture Capital and Family Office Investors; CIO's at the world's biggest superannuation funds; Leading Entertainers; Olympic Gold Medal Winning Athletes and interesting minds you wouldn't have heard of that are changing the world. Our parent company, Curiosity Centre is your on-demand intelligence hub for knowledge, connections and growth to achieve your potential, everyday. Join 200,000+ Investors, Founders, Functional Leaders, CEOs and Emerging Leaders. Learn with the world's best and be 1% better everyday at https://curiositycentre.com***   

What's up everyone, today we have the pleasure of sitting down with István Mészáros, Founder and CEO of Mitzu.io. (00:00) - Intro (01:00) - In This Episode (03:39) - How Warehouse Native Analytics Works (06:54) - BI vs Analytics vs Measurement vs Attribution (09:26) - Merging Web and Product Analytics With a Zero-Copy Architecture (14:53) - Feature or New Category? What Warehouse Native Really Means For Marketers (23:23) - How Decoupling Storage and Compute Lowers Analytics Costs (29:11) - How Composable CDPs Work with Lean Data Teams (34:32) - How Seat-Based Pricing Works in Warehouse Native Analytics (40:00) - What a Data Warehouse Does That Your CRM Never Will (42:12) - How AI-Assisted SQL Generation Works Without Breaking Trust (50:55) - How Warehouse Native Analytics Works (52:58) - How To Navigate Founder Burnout While Raising Kids Summary: István built a warehouse-native analytics layer that lets teams define metrics once, query them directly, and skip the messy syncs across five tools trying to guess what “active user” means. Instead of fighting over numbers, teams walk through SQL together, clean up logic, and move faster. One customer dropped their bill from $500K to $1K just by switching to seat-based pricing. István shares how AI helps, but only if you still understand the data underneath. This conversation shows what happens when marketing, product, and data finally work off the same source without second-guessing every report.About IstvánIstvan is the Founder and CEO of Mitzu.io, a warehouse-native product analytics platform built for modern data stacks like Snowflake, Databricks, BigQuery, Redshift, Athena, Postgres, Clickhouse, and Trino. Before launching Mitzu.io in 2023, he spent over a decade leading high-scale data engineering efforts at companies like Shapr3D and Skyscanner. At Shapr3D, he defined the long-term data strategy and built self-serve analytics infrastructure. At Skyscanner, he progressed from building backend systems serving millions of users to leading data engineering and analytics teams. Earlier in his career, he developed real-time diagnostic and control systems for the Large Hadron Collider at CERN. How Warehouse Native Analytics WorksMarketing tools like Mixpanel, Amplitude, and GA4 create their own versions of your customer. Each one captures data slightly differently, labels users in its own format, and forces you to guess how their identity stitching works. The warehouse-native model removes this overhead by putting all customer data into a central location before anything else happens. That means your data warehouse becomes the only source of truth, not just another system to reconcile.István explained the difference in blunt terms. “The data you're using is owned by you,” he said. That includes behavioral events, transactional logs, support tickets, email interactions, and product usage data. When everything lands in one place first (BigQuery, Redshift, Snowflake, Databricks) you get to define the logic. No more retrofitting vendor tools to work with messy exports or waiting for their UI to catch up with your question.In smaller teams, especially B2C startups, the benefits hit early. Without a shared warehouse, you get five tools trying to guess what an active user means. With a warehouse-native setup, you define that metric once and reuse it everywhere. You can query it in SQL, schedule your campaigns off it, and sync it with downstream tools like Customer.io or Braze. That way you can work faster, align across functions, and stop arguing about whose numbers are right.“You do most of the work in the warehouse for all the things you want to do in marketing,” István said. “That includes measurement, attribution, segmentation, everything starts from that central point.”Centralizing your stack also changes how your data team operates. Instead of reacting to reporting issues or chasing down inconsistent UTM strings, they build shared models the whole org can trust. Marketing ops gets reliable metrics, product teams get context, and leadership gets reports that actually match what customers are doing. Nobody wins when your attribution logic lives in a fragile dashboard that breaks every other week.Key takeaway: Warehouse native analytics gives you full control over customer data by letting you define core metrics once in your warehouse and reuse them everywhere else. That way you can avoid double-counting, reduce tool drift, and build a stable foundation that aligns marketing, product, and data teams. Store first, define once, activate wherever you want.BI vs Analytics vs Measurement vs AttributionBusiness intelligence means static dashboards. Not flexible. Not exploratory. Just there, like laminated truth. István described it as the place where the data expert's word becomes law. The dashboards are already built, the metrics are already defined, and any changes require a help ticket. BI exists to make sure everyone sees the same numbers, even if nobody knows exactly how they were calculated.Analytics lives one level below that, and it behaves very differently. It is messy, curious, and closer to the raw data. Analytics splits into two tracks: the version done by data professionals who build robust models with SQL and dbt, and the version done by non-technical teams poking around in self-serve tools. Those non-technical users rarely want to define warehouse logic from scratch. They want fast answers from big datasets without calling in reinforcements.“We used to call what we did self-service BI, because the word analytics didn't resonate,” István said. “But everyone was using it for product and marketing analytics. So we changed the copy.”The difference between analytics and BI has nothing to do with what the tool looks like. It has everything to do with who gets to use it and how. If only one person controls the dashboard, that is BI. If your whole team can dig into campaign performance, break down cohorts, and explore feature usage trends without waiting for data engineering, that is analytics. Attribution, ML, and forecasting live on top of both layers. They depend on the raw data underneath, and they are only useful if the definitions below them hold up.Language often lags behind how tools are actually used. István saw this firsthand. The product stayed the same, but the positioning changed. People used Mitzu for product analytics and marketing performance, so that became the headline. Not because it was a trend, but because that is what users were doing anyway.Key takeaway: BI centralizes truth through fixed dashboards, while analytics creates motion by giving more people access to raw data. When teams treat BI as the source of agreement and analytics as the source of discovery, they stop fighting over metrics and start asking better questions. That way you can maintain trusted dashboards for executive reporting and still empower teams to explore data without filing tickets or waiting days for answers.Merging Web and Product Analytics With a Zero-Copy ArchitectureMost teams trying to replace GA4 end up layering more tools onto the same mess. They drop in Amplitude or Mixpanel for product analytics, keep something else for marketing attribution, and sync everything into a CDP that now needs babysitting. Eventually, they start building one-off pipelines just to feed the same events into six different systems, all chasing slightly different answers to the same question.István sees this fragmentation as a byproduct of treating product and marketing analytics as separate functions. In categorie...

It's undeniable that the merits of diversity lay at the heart of David Bottrill's vast discography. With artists like Peter Gabriel, Smashing Pumpkins, Tool, Muse, Silverchair, Staind and Rush, David's work spans genres and generations, lending to a sound that is both familiar and progressive. He's cultivated the aggressive hard-rock palette of bands like Stone Sour, Godsmack, and Mastodon, while maintaining a connection to other ends of the spectrum with artists like Afrocelt Sound System, IAMX, and Nusrat Fateh Ali Khan. With three Grammy Awards and the success of millions of copies sold worldwide, David has produced and mixed platinum and gold career-defining albums that have established paradigms and redefined genres. “I prefer to work on music that has a strong identity and shows elements of originality,” David states, “genre isn't really important.” It's this focus on identity and potential that inspires David to push artists to curate the best of themselves and make music that defines who they are in that moment. And yet, even in their individuality, each album that David works on distinctly shows his fingerprint. David spent 20 years living in the UK and has just built a new Atmos mix and overdub studio in the greater Toronto area in his native country of Canada, although he still spends much of his time working with artists in various international locations. David has recently retired from the board of directors for Make Music Matter, but still supports the non-profit that uses the creation of music and socially conscious art to help heal trauma in marginalized communities and individuals. Through Make Music Matter, David found an outlet for his experience, truly helping better the lives of others and bringing awareness to the community at large.IN THIS EPISODE YOU'LL LEARN:Balancing the artist's vision vs giving people “what they want”Mixing in subgroupsBuilding mix templates to maximize creativity and speedCarving space in the low end to get clarityMixing with a subwooferThe downside of using reverbKnowing when to step away from a mix and restart later To learn more about David, visit: https://www.davidbottrill.com/Looking for 1-on-1 feedback and training to help you create pro-quality mixes?Check out my coaching program Amplitude and apply to join:https://masteryourmix.com/amplitude/ Want additional help with your music productions?For tips on how to improve your mixes, visit: https://masteryourmix.com/ Download your FREE copy of the Ultimate Mixing Blueprint: https://masteryourmix.com/blueprint/ Get your copy of my Amazon #1 bestselling books:The Recording Mindset: A Step-By-Step Guide to Creating Pro Recordings From Your Home Studio: https://therecordingmindset.com The Mixing Mindset: The Step-By-Step Formula For Creating Professional Rock Mixes From Your Home Studio: https://masteryourmix.com/mixingmindsetbook/ Check out our Sponsors:Download Waves Plugins here: https://waves.alzt.net/EK3G2K Subscribe to the show:Apple Podcasts:

In this episode of Future Finance, hosts Paul Barnhurst and Glenn Hopper sit down with Siqi Chen, founder and CEO of Runway. Siqi opens up about the challenges he faced understanding finance as a founder, and how those frustrations led him to build a more intuitive platform. The conversation explores what's broken in traditional finance tools and how better design can make finance easier to grasp for everyone in the business, not just the experts.Siqi is a builder and investor with a background that spans NASA, gaming, and high-growth startups. Before Runway, he led products at Zynga and Postmates, served as CEO of Sandbox VR, and invested in companies like Clubhouse and Amplitude. His journey gives him a unique perspective on how product design can solve real business pain points, especially in finance.Expect to Learn:Why traditional finance tools are often disliked.The common spreadsheet struggles growing teams face.How user-friendly design improves collaboration.Why Runway focuses on clarity and flexibility over complexity.What it means to build a thinking tool, not just a planning tool.Siqi shares practical, hard-earned insights on what it takes to build a truly useful finance platform, one that prioritizes clarity, flexibility, and collaboration. If you're frustrated by rigid systems or drowning in spreadsheet chaos, this episode offers a fresh perspective on how thoughtful design and a new approach to financial modeling can help you make better, faster decisions.Follow Siqi:LinkedIn - https://www.linkedin.com/in/siqic/Company - https://www.linkedin.com/company/runway/Twitter - https://x.com/bladerJoin hosts Glenn and Paul as they unravel the complexities of AI in finance:Follow Glenn:LinkedIn: https://www.linkedin.com/in/gbhopperiiiFollow Paul: LinkedIn - https://www.linkedin.com/in/thefpandaguyFollow QFlow.AI:Website - https://bit.ly/4i1EkjgFuture Finance is sponsored by QFlow.ai, the strategic finance platform solving the toughest part of planning and analysis: B2B revenue. Align sales, marketing, and finance, speed up decision-making, and lock in accountability with QFlow.ai. Stay tuned for a deeper understanding of how AI is shaping the future of finance and what it means for businesses and individuals alike.In Today's Episode:[01:05] - Origin of Runway[03:00] - Early Challenges & First Users[04:10] - Early Demo & Launch Delay[05:29] - User-Friendly Design[11:43] - Winning by Being Different[15:53] - Powerful Tech, Simple Design[16:33] - From Workflow to Thinking Tool

Episode #380 of BGMania: A Video Game Music Podcast. Today on the show, Bryan and Bedroth go beat-for-beat through a curated lineup of killer music from across the rhythm game spectrum—from lo-fi grooves and hypnotic trance to absolute chaos and comedic gold. We're highlighting tracks from genre staples like Amplitude, Parappa the Rapper, Thumper, and Crypt of the NecroDancer, while also diving into lesser-known but equally brilliant titles like Zubo, Melatonin, Tadpole Treble, and Mad Rat Dead. Whether you're a longtime rhythm game junkie or a casual toe-tapper, this episode has something for every kind of beat-matcher. Turn up the volume, find your groove, and get ready to vibe. Email the show at bgmaniapodcast@gmail.com with requests for upcoming episodes, questions, feedback, comments, concerns, or any other thoughts you'd like to share! Special thanks to our Executive Producers: Jexak, Xancu, Jeff & Mike. EPISODE PLAYLIST AND CREDITS Konga Conga Kappa -King Conga- from Crypt of the NecroDancer [Danny Baranowsky, 2015] Break For Me from Amplitude [James Landino feat. Noelle Leblanc, 2016] See It from Frequency [Paul Oakenfold, 2001] Stasis from Lanota [Maozon, 2016] All Master's Rap -Bathroom Song- from Parappa the Rapper [Masaya Matsuura feat. Dred Foxx, Ryu Watabe, Sandra, Lenky Don & Michele Burks, 1996] Team Seas Ahoy from Zubo [Christian Henson, Joe Henson & Alexis Smith, 2008] Buzzooka Brawl from HarmoKnight [Minako Adachi, Nobuo Kiyota, Kiyoto Ohtani & Kiyohiro Sada, 2012] New Day from Melatonin [cademakesmusic, 2022] Thunder Creek from Tadpole Treble [Matthew Taranto feat. Jason Dowies & Chet Tucker, 2016] Beetle from Thumper [Brian Gibson, 2016] Snow Falls, a Light Far Away from JACKJEANNE [Akira Kosemura, 2021] 12 o'clock from Goodbye Volcano High [Dabu & Brigitte Naggar, 2023] Distorted Graffiti from Mad Rat Dead [Yoh Ohyama, 2020] Rondo a la Destroyer v. Inventor from Hextech Mayhem: A League of Legends Story [Stemage, 2021] LINKS Patreon: https://patreon.com/bgmania Website: https://bgmania.podbean.com/ Discord: https://discord.gg/cC73Heu Facebook: BGManiaPodcast X: BGManiaPodcast Instagram: BGManiaPodcast TikTok: BGManiaPodcast YouTube: BGManiaPodcast Twitch: BGManiaPodcast PODCAST NETWORK Very Good Music: A VGM Podcast Listening Religiously

Tokyo Speirs is a multi-Platinum-certified Canadian record producer, audio engineer and songwriter from the Greater Toronto Area.He has worked with many charting artists via Walk Off The Earth, such as Lindsey Stirling, Lukas Graham, Phillip Phillips, Gabriela Bee, USS, and Luminati Suns. With certified gold singles such as “Fire in my Soul,” Platinum on their 2019 full-length album "Here We Go," which peaked as the #1 selling pop album in America (Nielsen's Pop Album Chart), #3 on Canada's Top Albums Chart, and debuted in the Top 5 on Billboard's Album Sales Chart, and Platinum on their latest Album “Stand By Me” which included the Platinum-certified smash hit “My Stupid Heart,” with the help of viral TikToks and creative live performances. He has co-written and co-produced the Pokémon Journeys theme song, Disney's Go Away Unicorn and Blade Runner Black Lotus. Using unconventional samples, creative lyrics and unique recording techniques, Tokyo pushes the boundaries while reigning in the weirder side of pop. Having also gained respect in songwriting and mastering, at the end of the day, he's just a friendly engineer (friendgineer?) who strives to draw intimate, captivating performances, whether that means invisibly recording or pushing talent as far as possible to get the take.He is currently working and performing with Walk Off the Earth, producing Luminati Suns, as well as dipping his toes into video production and live production.IN THIS EPISODE YOU'LL LEARN:Finding your niche in productionBeing strong-willed to push your skillsLetting experimentation inspire creativityWorking and writing with Walk Off The EarthTreating music as a jobThe inner workings of a successful bandSetting up roles for different members of a bandRecording unique instrumentsPrioritizing during the recording and mixing stagesKnowing when to spend time on something vs. moving onScheduling your life around musicHow he organizes his files, sessions, and ideasHow to make choruses that are hugeTo learn more about Tokyo Speirs, visit: https://www.instagram.com/friendgineer/Check out Walk Off The Earth on tour: https://tour.walkofftheearth.com/And check out their latest single: https://orcd.co/breakingmyheartLooking for 1-on-1 feedback and training to help you create pro-quality mixes?Check out my coaching program Amplitude and apply to join:https://masteryourmix.com/amplitude/ Want additional help with your music productions?For tips on how to improve your mixes, visit: https://masteryourmix.com/ Download your FREE copy of the Ultimate Mixing Blueprint: https://masteryourmix.com/blueprint/ Get your copy of my Amazon #1 bestselling books:The Recording Mindset: A Step-By-Step Guide to Creating Pro Recordings From Your Home Studio: https://therecordingmindset.com The Mixing Mindset: The Step-By-Step Formula For Creating Professional Rock Mixes From Your Home Studio: https://masteryourmix.com/mixingmindsetbook/ Check out our...

In this episode of Future Finance, hosts Paul Barnhurst and Glenn Hopper welcome Siqi Chen, founder and CEO of Runway, a finance platform built to help operators understand their business without needing a degree in finance. The discussion explores how traditional FP&A tools fall short, and why Runway is reimagining financial modeling by combining flexibility, design, and deeper thinking. Siqi is the founder and CEO of Runway, a modeling platform designed for operators and finance professionals who need flexible, intuitive tools to manage business complexity. He previously served as CEO of Sandbox VR, VP of Product at Postmates, and Head of Product at Zynga. Siqi has also invested in over 100 startups, including Clubhouse, Amplitude, Pipe, and Italic. Early in his career, he worked at NASA, where he was awarded a Congressional Space Act Award while still in school for his work on the Mars Exploration Rover.In this episode, you will discover:Why FP&A platforms often fail to replace spreadsheets for financial modeling.How Runway is addressing the core pains of collaboration, complexity, and data integration.Why flexibility and speed of thought matter more than workflow automation.How Siqi thinks about AI's role in making finance tools more usable and accessible.A remarkable story of how a meme coin helped fund life-saving research for his daughter's brain tumor.Siqi shared his remarkable journey from NASA engineer and tech executive to founder of a finance platform built for modern operators. His experiences across product leadership, startup growth, and personal resilience highlight why tools like Runway are redefining how finance professionals think, plan, and collaborate. This episode is a must-listen for anyone looking to move beyond outdated systems and embrace a more flexible, human-centered approach to financial modeling and decision-making.Follow Siqi:LinkedIn - https://www.linkedin.com/in/siqic/Company - https://www.linkedin.com/company/runway/Join hosts Glenn and Paul as they unravel the complexities of AI in finance:Follow Glenn:LinkedIn: https://www.linkedin.com/in/gbhopperiiiFollow Paul:LinkedIn - https://www.linkedin.com/in/thefpandaguyFollow QFlow.AI:Website - https://bit.ly/4i1EkjgFuture Finance is sponsored by QFlow.ai, the strategic finance platform solving the toughest part of planning and analysis: B2B revenue. Align sales, marketing, and finance, speed up decision-making, and lock in accountability with QFlow.ai. Stay tuned for a deeper understanding of how AI is shaping the future of finance and what it means for businesses and individuals alike.In Today's Episode:[01:48] - Siqi's Background[04:41] - Runway Journey So Far[07:11] - Approachable Finance Tools[14:28] - UX & What Makes Runway Unique[20:26] - Thinking Tool Idea[24:28] - Excel Flexibility Trade-Offs[33:46] - AI as a Financial Exoskeleton[40:21] - The Meme Coin Surprise[44:40] - Wrap-Up

Amplitude térmica marca o período e não se descarta possibilidade de geada

Too often, product managers work as human middleware between their teams and tools, burning out great people with administrative friction instead of building energising high-performance cultures. Life is short—you need to get your time back. In this episode, Ross Webb (who built product teams at Amazon serving 80,000+ IT professionals) explores how AI transforms team leadership by streamlining management processes, reducing PM stress, and enabling sustainable high performance. What You'll Learn: Why top product leaders think like part-time recruiters and become "talent factories"How actively seeking to be wrong makes you a better, more effective leaderThe balance between decision-making authority and collaborative experimentationHow to drive high performance whilst preventing team burnout and maintaining wellbeingHow AI can automate performance tracking, workload balancing, and communication coordination Featured Guests: Jordan Burton - Talent development expert on the "talent factory" mindset and ecosystem buildingHarrison Baker - Leadership specialist on curiosity, questioning, and situational readingAnnika Schmid - Decision-making strategist on reversible vs irreversible choices and rapid experimentationKris Jones - Performance management expert on sustainable high performance and burnout prevention Key Takeaways: High-performance teams aren't about finding perfect people—they're about creating systems for excellenceThe shift from "smartest person in the room" to "surround myself with incredible talent" defines leadershipSpeed of learning often trumps perfection of planning in most product decisionsAI can eliminate the administrative burden that burns out talented team members Sponsored by FlowFocus AI - The agentic AI system that connects your entire product stack (Jira, Amplitude, PostHog, roadmapping tools, competitive intelligence) and saves product managers 5-10 hours per week. Because life is too short to be human middleware.

Los mitos forman parte de la estructura narrativa de todos los pueblos. Relatos que intentan explicar el origen del mundo, los fenómenos naturales o ciertos sucesos para los que no hay una explicación racional. En esa línea se sitúa 'Calabobos', la novela de Luis Mario, que bebe de la mitología cántabra para construir una historia oral donde destaca una heroína: Mariuca. Su madre, el viejo, Nanda la Chona y su familia, Suco, Chanín y el narrador —hermano de Mariuca— componen un universo popular que el autor modela con una lengua cercana y narrativa de raíz oral. Una historia familiar e iniciática que se entreteje con las leyendas del norte.En nuestra sección infantil, Leticia Audibert abre la Pequeteca con 'El libro más querido del bosque', escrito por Mar Pico Seijo e ilustrado por Anastasia Wessex, y editado por La Galera. Una historia que reivindica el amor por la lectura y la fuerza del libro como espacio compartido.Con Mery Cuesta nos detenemos en la exposición 'Néstor Reencontrado' en el Museo Reina Sofía, que rescata la figura de Néstor Martín-Fernández de la Torre. El artista canario, muy presente en la España de la Edad de Plata, ha caído en el olvido fuera de su tierra natal. Esta muestra reúne más de cien piezas que reflejan su eclecticismo, desde el simbolismo al modernismo, pasando por el art déco.Además, Concha Álvarez nos guía por algunas de las exposiciones del MUSAC de León, en el marco de su 20º aniversario. El museo acoge obras como El bramido de la tierra, de Luis Moro; los murales de gran formato de Secundino Hernández en Estación total; y las esculturas cinéticas Meadow y Amplitude, de Studio Drift, que combinan tecnología, movimiento y naturaleza.Escuchar audio

Justin Francis has a knack for channeling emotion through sound. His multi-faceted and innovative recording approach as a Grammy award- winning engineer, mixer, and producer has led to a lineage of work with a range of artists across an eclectic spectrum of musical genres. Raised in western Pennsylvania and now having immersed himself in the Nashville music scene for well over a decade, he has worked alongside artists like Sheryl Crow, Kacey Musgraves, Tyler Childers, Lake Street Dive, Justin Timberlake, Madison Cunningham, Gary Clark Jr, Sarah Jarosz, and Lauren Daigle. Justin's dedication to serving the song, paired with an intention to advocate for and uplift artists, makes him one of the most sought-after creative minds in music today.IN THIS EPISODE YOU'LL LEARN:Moving to Nashville to break into the industryGoing freelance after years of working in a big studioServing parts, not instrumentsThe importance of starting a mix with volume and panning onlyCreating space for vocals in a mixSidechaining instrumentation based on vocalsSetting up your sessions to help you work efficiently and have ultimate control over your processingBeing intentional with effectsHow tracking with effects can change the vibe of a sessionLearning to let go and not constantly tweak your settingsWorking with Sheryl Crow and Maddison CunninghamTo learn more about Justin Francis, visit: https://www.jryanfrancis.com/Looking for 1-on-1 feedback and training to help you create pro-quality mixes?Check out my coaching program Amplitude and apply to join:https://masteryourmix.com/amplitude/ Want additional help with your music productions?For tips on how to improve your mixes, visit: https://masteryourmix.com/ Download your FREE copy of the Ultimate Mixing Blueprint: https://masteryourmix.com/blueprint/ Get your copy of my Amazon #1 bestselling books:The Recording Mindset: A Step-By-Step Guide to Creating Pro Recordings From Your Home Studio: https://therecordingmindset.com The Mixing Mindset: The Step-By-Step Formula For Creating Professional Rock Mixes From Your Home Studio: https://masteryourmix.com/mixingmindsetbook/ Check out our Sponsors:Download Waves Plugins here: https://waves.alzt.net/EK3G2K Subscribe to the show:Apple Podcasts: https://podcasts.apple.com/us/podcast/master-your-mix-podcast/id1240842781 Spotify: https://open.spotify.com/show/5V4xtrWSnpA5e9L67QcJej Youtube: http://www.youtube.com/@MasterYourMix Have questions you'd like answered on the show?Send them to questions@masteryourmix.comPlease leave a rating and review:https://masteryourmix.com/review/...

Too often, product managers work as human middleware between systems and stakeholders, drowning in administrative overhead instead of driving strategic change. Life is short—you need to get your time back. In this episode, Ross Webb (who led product transformations at Amazon and Just Eat) explores how AI transforms leadership effectiveness by handling administrative burden, freeing leaders to focus on strategic thinking and meaningful change management. What You'll Learn: Why compassion alone won't drive lasting transformation in established organisationsHow to standardise platform integrations to unlock 30% year-on-year growthThe balance between rigorous planning and genuine agile principles (not "lean theatre")How to build crucial stakeholder alliances when you're the outsider coming inHow AI can automate status updates, reporting, and process coordination Featured Guests: David Behlich - Transformation specialist who's driven change in 70,000+ person organisationsDominic Le Garsmeur - Platform strategy expert who achieved 30% YoY growth through standardisationKris Jones - Strategic planning advocate who balances preparation with agilityNiko Korner - Organisational politics navigator and stakeholder alliance builder Key Takeaways: Successful transformation requires both inspiration AND enforcement—some people need to be movedFocus on foundation before chasing growth; sometimes slow down to speed upUnderstanding organisational politics is essential for senior product leadershipAI can eliminate the administrative friction that keeps leaders reactive instead of proactive Sponsored by FlowFocus AI - The agentic AI system that connects your entire product stack (Jira, Amplitude, PostHog, roadmapping tools, competitive intelligence) and saves product managers 5-10 hours per week. Because life is too short to be human middleware.

A Celebration of Juneteenth with Leaders of Color in Academia, Medicine, Engineering and Athletics. Here is the complete list: Chancellor Gary May ( Chancellor of UC Davis), Dean Raheem Beyah (Dean, College of Engineering, Georgia Tech), Dr. Emery Brown, MD, PhD ( Anesthesiologist-Statistician, Harvard/ MIT/ Mass. General Hospital), Chase Griffin ( Toigo Fellow, Investment Fellow, Athlete Creator and Quarterback, UCLA), Nagela Nukuna (Product Lead, The White House), Leselle Vincent ( Senior Associate, Center for Public Impact), Sonola Onasanya ( ESG Equity Analyst, Net Purpose), Gabriel Galaraza (Professional Services Manager, Amplitude), Kyle Woumn (Engineering Manager, Nerd Wallet and Forbes 30 Under 30, 2022), Ms. Pinder (Vice Principal, Bishop Michael Eldon School, The Bahamas), Mr. Bourne ( Chemistry Teacher, B.M.E.S.) ,Mr. R. Deveaux (Deputy Permanent Secretary, The Ministry of Education, The Bahamas), Former Ambassador S. Collie ( Former Bahamian Ambassador to Washington, DC), Mr. Isaiah Swann ( MD-PhD Student at The University of Virginia), Dr. Jenaye Burrows, MBBS (Medical Doctor), Chadwin Hanna ( MD-PhD Student, The University of Florida), Dr. Kuna Fortingo, MD ( Medical Resident), Dr. Sheena Collie (Chief Medical Officer, Doctors Hospital, The Bahamas), Aaron Levarity (Professional Basketball Player in France & from The Bahamas).

Welcome to another episode of the Oncology Brothers podcast! In this episode, Drs. Rahul and Rohit Gosain, both practicing community oncologists, are joined by Dr. Tian Zhang from UT Southwestern to discuss key highlights from the ASCO 2025 annual meeting, focusing on genitourinary (GU) malignancies. Episode Highlights: • KEYNOTE-564: discussed 5 years OS data, reinforcing the role of adjuvant pembrolizumab in renal cell carcinoma • AMPLITUDE: combination of PARP inhibitor niraparib with abiraterone improved progression-free survival in patients with homologous recombination repair mutations in metastatic hormone-sensitive prostate cancer • ARANOTE: positive quality of life impact when using darolutamide in metastatic hormone-sensitive prostate cancer, which is also FDA approved now • NIAGARA: the prognostic value of ctDNA in muscle-invasive bladder cancer, emphasizing its implications for treatment strategies YouTube: https://youtu.be/Rt8HQpdyVY0 Follow us on social media: •⁠  ⁠X/Twitter: https://twitter.com/oncbrothers •⁠  ⁠Instagram: https://www.instagram.com/oncbrothers •⁠  Website: https://oncbrothers.com/ Join us as we break down these important studies and their potential to change clinical practice in oncology. Don't forget to check out our other episodes for more insights into cancer care!

Phil Greiss is a French-Canadian producer, songwriter, mix engineer, and multi-instrumentalist known for his genre-blending work in global pop and Latin music. He co-wrote and co-produced the chart-topping hit “Savage Love” by Jason Derulo and Jawsh 685, earning a 2021 ASCAP Pop Award. Greiss was also behind the production and mixing of J Balvin's “Mi Gente,” which became a massive global success and earned him Latin Grammy nominations and over 68× RIAA Platinum certifications.Launching his career in France with acclaimed albums for artists like Corneille and Zaho, Greiss broke into the international scene after co-producing Willy William's “Voodoo Song,” which became the foundation for “Mi Gente.” Since then, he has worked with high-profile artists including Beyoncé, Nicki Minaj, David Guetta, and BTS, producing hits like “Goodbye” and “Metele Al Perreo.” His recent work continues to bridge cultures and genres, solidifying his role as a leading force in contemporary pop and Latin music.IN THIS EPISODE YOU'LL LEARN:Following your passions, despite societal/parental pushbackTrusting your earsLearning to understand the “sound” of your plugins/hardwareThe key to success as a songwriterWhat publishers are looking for in a songwriterBeing a “finisher”Balancing creativity vs. technical: how to prevent each one from harming the otherWriting songs for viralityUsing clipping in your mixesWorking with limitationsBuilding your workflow for predictable resultsTo learn more about Phil Greiss, visit: https://about.me/philgreissLooking for 1-on-1 feedback and training to help you create pro-quality mixes?Check out my coaching program Amplitude and apply to join:https://masteryourmix.com/amplitude/ Want additional help with your music productions?For tips on how to improve your mixes, visit: https://masteryourmix.com/ Download your FREE copy of the Ultimate Mixing Blueprint: https://masteryourmix.com/blueprint/ Get your copy of my Amazon #1 bestselling books:The Recording Mindset: A Step-By-Step Guide to Creating Pro Recordings From Your Home Studio: https://therecordingmindset.com The Mixing Mindset: The Step-By-Step Formula For Creating Professional Rock Mixes From Your Home Studio: https://masteryourmix.com/mixingmindsetbook/ Check out our Sponsors:Download Waves Plugins here: https://waves.alzt.net/EK3G2K Subscribe to the show:Apple Podcasts: https://podcasts.apple.com/us/podcast/master-your-mix-podcast/id1240842781 Spotify: https://open.spotify.com/show/5V4xtrWSnpA5e9L67QcJej Youtube: http://www.youtube.com/@MasterYourMix Have questions you'd like answered on the show?Send them to

Too often, product managers work as human middleware between tools, teams, and market intelligence. Life is short—you need to get your time back. In this episode, Ross Webb (former Principal PM at Amazon and Just Eat, who took products from 0 to £50M+ revenue) explores how AI agents are transforming go-to-market success by automating research, competitive analysis, and cross-functional alignment workflows. What You'll Learn: Why B2B2B environments require different GTM strategies and how to navigate complex stakeholder layersThe "echo-back approach" that transforms customer problems into quantifiable business valueHow to build genuine harmony between sales and product teams (not just tolerance)Ecosystem design thinking: ensuring every piece needed for market success is alignedHow AI agents can automate competitive intelligence and market validation workflows Featured Guests: João Moreira - Product leadership expert on B2B2B complexity and cross-team collaborationTzvika Shahaf - Strategic consultant on customer problem validation and business value translationDavid Moore - Sales-product alignment specialist and relationship building expertAlba Simon - Ecosystem design thinking pioneer and organisational strategy expert Key Takeaways: Product-market fit requires orchestrating the entire ecosystem, not just building great productsDirect customer engagement beats secondhand feedback from sales teams every timeUnderstanding each team's KPIs and workflows creates win-win collaboration opportunitiesAI can automate the administrative burden of market research, freeing PMs for strategic thinking Sponsored by FlowFocus AI - The agentic AI system that connects your entire product stack (Jira, Amplitude, PostHog, roadmapping tools, competitive intelligence) and saves product managers 5-10 hours per week. Because life is too short to be human middleware.

Dr. Neeraj Agarwal and Dr. Jeanny Aragon-Ching discuss important advances in the treatment of prostate, bladder, and kidney cancers that were presented at the 2025 ASCO Annual Meeting. TRANSCRIPT Dr. Neeraj Agarwal: Hello, and welcome to the ASCO Daily News Podcast. I am Dr. Neeraj Agarwal, your guest host of the ASCO Daily News Podcast today. I am the director of the Genitourinary Oncology Program and a professor of medicine at the University of Utah Huntsman Cancer Institute and editor-in-chief of the ASCO Daily News.  I am delighted to be joined by Dr. Jeanny Aragon-Ching, a GU medical oncologist and the clinical program director of the GU Center at the Inova Schar Cancer Institute in Virginia. Today, we will be discussing some key abstracts in GU oncology that were presented at the 2025 ASCO Annual Meeting.  Our full disclosures are available in the transcript of this episode.  Jeanny, it is great to have you on the podcast. Dr. Jeanny Aragon-Ching: Oh, thank you so much, Neeraj. Dr. Neeraj Agarwal: Jeanny, let's begin with some prostate cancer abstracts. Let's begin with Abstract 5017 titled, “Phase 1 study results of JNJ-78278343 (pasritamig) in metastatic castration-resistant prostate cancer.” Can you walk us through the design and the key findings of this first-in-human trial? Dr. Jeanny Aragon-Ching: Yeah, absolutely, Neeraj. So this study, presented by Dr. Capucine Baldini, introduces pasritamig, a first-in-class T-cell redirecting bispecific antibody that simultaneously binds KLK2 on prostate cancer cells and CD3 receptor complexes on T cells. KLK2 is also known as human kallikrein 2, which is selectively expressed in prostate tissue. And for reference, KLK3 is what we now know as the PSA, prostate-specific antigen, therefore making it an attractive and specific target for therapeutic engagement. Now, while this was an early, first-in-human, phase 1 study, it enrolled 174 heavily pretreated metastatic CRPC patients. So many were previously treated with ARPIs, taxanes, and radioligand therapy. So given the phase 1 nature of this study, the primary objective was to determine the safety and the RP2D, which is the recommended phase 2 dose. Secondary objectives included preliminary assessment of antitumor activity. So, pasritamig was generally well tolerated. There were no treatment-related deaths. Serious adverse events were rare. And in the RP2D safety cohort, where patients received the step-up dosing up to 300 mg of IV every 6 weeks, the most common treatment-related adverse events were low-grade infusion reactions. There was fatigue and grade 1 cytokine release syndrome, what we call CRS. And no cases of neurotoxicity, or what we call ICANS, the immune effector cell-associated neurotoxicity syndrome, reported. Importantly, the CRS occurred in just about 8.9% of patients. All were grade 1. No patients required tocilizumab or discontinued treatment due to adverse events. So, this suggests a favorable safety profile, allowing hopefully for outpatient administration without hospitalization, which will be very important when we're thinking about bispecifics moving forward. In terms of efficacy, pasritamig showed promising activity. About 42.4% of evaluable patients achieved a PSA50 response. Radiographic PFS was about 6.8 months. And among patients with measurable disease, the objective response rate was about 16.1% in those with lymph node or bone metastases, and about 3.7% in those with visceral disease, with a median duration of response of about 11.3 months. So, altogether, this data suggests that pasritamig may offer a well-tolerated and active new potential option for patients with metastatic CRPC.   Again, as a reminder, with the caveat that this is still an early phase 1 study. Dr. Neeraj Agarwal: Thank you, Jeanny. These are promising results for a bispecific T-cell engager, pasritamig, in prostate cancer. I agree, the safety and durability observed here stand out, and this opens the door for further development, possibly even in earlier disease settings.  So, shifting now from immunotherapy to the evolving role of genomics in prostate cancer. So let's discuss Abstract 5094, a real-world, retrospective analysis exploring the prognostic impact of homologous recombination repair gene mutations, especially BRCA1 and BRCA2 mutations, in metastatic hormone-sensitive prostate cancer. Can you tell us more about this abstract, Jeanny? Dr. Jeanny Aragon-Ching: Sure, Neeraj. So this study was presented by Dr. David Olmos, represents one of the largest real-world analyses we have evaluating the impact of homologous recombination repair, or what we would call HRR, alterations in metastatic hormone-sensitive prostate cancer. So, this cohort included 556 men who underwent paired germline and somatic testing. Now, about 30% of patients had HRR alterations, with about 12% harboring BRCA1 or BRCA2 mutations and 16% having alterations in other HRR genes. Importantly, patients were stratified via CHAARTED disease volume, and outcomes were examined across treatment approaches, including ADT alone, doublet therapy, and triplet therapy. The prevalence of BRCA and HRR alterations were about similar between the metastatic hormone-sensitive prostate cancer and the metastatic castrate-resistant prostate cancer, with no differences observed, actually, between the patients with high volume versus low volume disease.  So, the key finding was that BRCA and HRR alterations were associated with poor clinical outcomes in metastatic hormone-sensitive prostate cancer. And notably, the impact of these alterations may actually be even greater in metastatic hormone-sensitive prostate cancer than previously reported in metastatic CRPC. So, the data showed that when BRCA mutations are present, the impact of the volume of disease is actually limited. So, poor outcomes were observed across the board for both high-volume and low-volume groups. So, the analysis showed that patients with HRR alterations had significantly worse outcomes compared to patients without HRR alterations. Median radiographic progression-free survival was about 20.5 months for the HRR-altered patients versus 30.6 months for the non-HRR patients, with a hazard ratio of 1.6. Median overall survival was 39 months for HRR-altered patients compared to 55.7 months for the non-HRR patients, with a hazard ratio of 1.5. Similar significant differences were observed when BRCA-mutant patients were compared with patients harboring non-BRCA HRR mutations. Overall, poor outcomes were independent of treatment of ARPI or taxanes. Dr. Neeraj Agarwal: Thank you, Jeanny. So, these data reinforce homologous recombination repair mutations as both a predictive and prognostic biomarker, not only in the mCRPC, but also in the metastatic hormone-sensitive setting as well. It also makes a strong case for incorporating genomic testing early in the disease course and not waiting until our patients have castration-resistant disease. Dr. Jeanny Aragon-Ching: Absolutely, Neeraj. And I think this really brings home the point and the lead up to the AMPLITUDE trial, which is LBA5006, a phase 3 trial that builds on this very concept of testing with a PARP inhibitor, niraparib, in the hormone-sensitive space. Can you tell us a little bit more about this abstract, Neeraj? Dr. Neeraj Agarwal: Sure. So, the AMPLITUDE trial, a phase 3 trial presented by Dr. Gerhardt Attard, enrolled 696 patients with metastatic hormone-sensitive prostate cancer and HRR gene alterations. 56% of these patients had BRCA1 and BRCA2 mutations. Patients were randomized to receive abiraterone with or without niraparib, a PARP inhibitor. The majority of patients, 78% of these patients, had high-volume metastatic hormone-sensitive prostate cancer, and 87% of these patients had de novo metastatic HSPC. And 16% of these patients received prior docetaxel, which was allowed in the clinical trial. So, with a median follow-up of nearly 31 months, radiographic progression-free survival was significantly prolonged with the niraparib plus abiraterone combination, and median was not reached in this arm, compared to abiraterone alone, which was 29.5 months, with a hazard ratio of 0.63, translating to a 37% reduction in risk of progression or death. This benefit was even more pronounced in the BRCA1 and BRCA2 subgroup, with a 48% reduction in risk of progression, with a hazard ratio of 0.52. Time to symptomatic progression also improved significantly across all patients, including patients with BRCA1, BRCA2, and HRR mutations. Although overall survival data remain immature, early trends favored the niraparib plus abiraterone combination. The safety profile was consistent with prior PARP inhibitor studies, with grade 3 or higher anemia and hypertension were more common but manageable. Treatment discontinuation due to adverse events remained low at 11%, suggesting that timely dose modifications when our patients experience grade 3 side effects may allow our patients to continue treatment without discontinuation. These findings support niraparib plus abiraterone as a potential new standard of care in our patients with metastatic hormone-sensitive prostate cancer with HRR alterations, and especially in those who had BRCA1 and BRCA2 mutations. Dr. Jeanny Aragon-Ching: Thank you, Neeraj. This trial is especially exciting because it brings PARP inhibitors earlier into the treatment paradigm. Dr. Neeraj Agarwal: Exactly. And it is exciting to see the effect of PARP inhibitors in the earlier setting.  So Jeanny, now let's switch gears a bit to bladder cancer, which also saw several impactful studies. Could you tell us about Abstract 4502, an exploratory analysis from the EV-302 trial, which led to approval of enfortumab vedotin plus pembrolizumab for our patients with newly diagnosed metastatic bladder cancer? So here, the authors looked at the outcomes in patients who achieved a confirmed complete response with EV plus pembrolizumab. Dr. Jeanny Aragon-Ching: Sure, Neeraj. So, EV-302 demonstrated significant improvements in progression-free and overall survival for patients previously treated locally advanced or metastatic urothelial cancer, I'll just call it metastatic UC, as a frontline strategy, establishing EV, which is enfortumab vedotin, plus pembro, with pembrolizumab as standard of care in this setting.  So, this year at ASCO, Dr Shilpa Gupta presented this exploratory responder analysis from the phase 3 EV-302 trial. Among 886 randomized patients, about 30.4% of patients, this is about 133, in the EV+P arm, and 14.5% of the patients in the chemotherapy arm, achieved a confirmed complete response. They call it the CCR rates. So for patients who achieved this, median PFS was not reached with EV+P compared to 26.9 months with chemotherapy, with a hazard ratio of 0.36, translating to a 64% reduction in the risk of progression. Overall survival was also improved. So the median OS was not reached in either arm, but the hazard ratio favored the EV+P at 0.37, translating to a 63% reduction in the risk of death. The median duration of complete response was not reached with EV+P compared to 15.2 months with chemotherapy. And among those patients who had confirmed CRs at 24 months, 78% of patients with the EV+P arm remained progression-free, and around 95% of the patients were alive, compared to 54% of patients who were progression-free and 86% alive of the patients in the chemotherapy arm. Safety among responders were also consistent with prior reports. Grade 3 or higher treatment-related adverse events occurred in 62% of EV+P responders and 72% of chemotherapy responders. Most adverse events were managed with dose modifications, and importantly, no treatment-related deaths were reported among those who were able to achieve complete response.  So these findings further reinforce EV and pembro as the preferred first-line therapy for metastatic urothelial carcinoma, offering a higher likelihood of deep, durable responses with a fairly manageable safety profile. Dr. Neeraj Agarwal: Thank you for the great summary, Jeanny. These findings underscore the depth and durability of responses achievable with this combination and also suggest that achieving a response may be a surrogate for long-term benefit in patients with metastatic urothelial carcinoma.  So now, let's move to Abstract 4503, an exploratory ctDNA analysis from the NIAGARA trial, which evaluated perioperative durvalumab, an immune checkpoint inhibitor, in muscle-invasive bladder cancer. So what can you tell us about this abstract? Dr. Jeanny Aragon-Ching: Absolutely, Neeraj. So, in NIAGARA, presented by Dr. Tom Powles, the addition of perioperative durvalumab to neoadjuvant chemotherapy, gem/cis, significantly improved event-free survival, overall survival, and pathologic complete response in patients with cisplatin-eligible muscle-invasive bladder cancer. Recall that this led to the U.S. FDA approval of this treatment regimen on March 28, 2025.  So, a planned exploratory analysis evaluated the ctDNA dynamics and their association with clinical outcomes, which was the one presented recently at ASCO. So, the study found that the incidence of finding ctDNA positivity in these patients was about 57%. Following neoadjuvant treatment, this dropped to about 22%, with ctDNA clearance being more common in the durvalumab arm, about 41%, compared to the chemotherapy control arm of 31%. Notably, 97% of patients who remained ctDNA positive prior to surgery failed to achieve a pathologic CR. So, this indicates a strong association between ctDNA persistence and lack of tumor eradication. So, postoperatively, only about 9% of patients were ctDNA positive. So, importantly, durvalumab conferred an event-free survival benefit regardless of ctDNA status at both baseline and post-surgery. Among patients who were ctDNA positive at baseline, durvalumab led to a hazard ratio of 0.73 for EFS. So, this translates to a 27% reduction in the risk of disease recurrence, progression, or death compared to the control arm. In the post-surgical ctDNA-positive group, the disease-free survival was also improved with a hazard ratio of 0.49, translating to a 51% reduction in the risk of recurrence.  So, these findings underscore the prognostic value of ctDNA and suggest that durvalumab provides clinical benefit irrespective of molecular residual disease status. So, the data also supports that ctDNA is a promising biomarker for future personalized strategies in the perioperative treatment of muscle-invasive bladder cancer. Dr. Neeraj Agarwal: Thank you, Jeanny. It is great to see that durvalumab is improving outcomes in these patients regardless of ctDNA status. However, based on these data, presence of ctDNA in our patients warrants a closer follow-up with imaging studies, because these patients with positive ctDNA seem to have a higher risk of recurrence. Dr. Jeanny Aragon-Ching: I agree, Neeraj.  Let's round out the bladder cancer discussion with Abstract 4518, which reported the interim results of SURE-02, which is a phase 2 study evaluating neoadjuvant sacituzumab govitecan plus pembrolizumab in cisplatin-ineligible muscle-invasive bladder cancer. Can you tell us more about this abstract, Neeraj? Dr. Neeraj Agarwal: Sure, Jeanny. So, Dr Andrea Necchi presented interim results from the SURE-02 trial. This is a phase 2 study evaluating neoadjuvant sacituzumab govitecan plus pembrolizumab, followed by a response-adapted bladder-sparing treatment and adjuvant pembrolizumab in patients with muscle-invasive bladder cancer.  So, in this interim analysis, 40 patients were treated and 31 patients were evaluable for efficacy. So, the clinical complete response rate was 38.7%. All patients achieving clinical complete response underwent bladder-sparing approach with a repeat TURBT instead of radical cystectomy. Additionally, 51.6% of patients achieved excellent pathologic response with a T stage of 1 or less after neoadjuvant therapy. The treatment was well tolerated, with only 12.9% of patients experiencing grade 3 or higher adverse events without needing dose reduction of sacituzumab. Molecular profiling, interestingly, showed that clinical complete response correlated with luminal and genomically unstable subtypes, while high stromal gene expression was associated with lack of response.  These results suggest that sacituzumab plus pembrolizumab combination has promising activity in this setting, and tolerability, and along with other factors may potentially allow a bladder preservation approach in a substantial number of patients down the line. Dr. Jeanny Aragon-Ching: Yeah, agree with you, Neeraj. And the findings are very provocative and support completing the full trial enrollment and further exploration of this strategy in muscle-invasive bladder cancer in order to improve and provide further bladder-sparing strategies. Dr. Neeraj Agarwal: Agree. So, let's now turn to the kidney cancer, starting with Abstract 4505, the final overall analysis from CheckMate-214 trial, which evaluated nivolumab plus ipilimumab, so dual checkpoint inhibition strategy, versus sunitinib in our patients with metastatic clear cell renal cell carcinoma. Dr. Jeanny Aragon-Ching: Yeah, absolutely, Neeraj. So, the final 9-year analysis of the phase 3 CheckMate-214 trial confirms the long-term superiority of nivolumab and ipilimumab over sunitinib for first-line treatment of advanced metastatic renal cell carcinoma. So, this has a median follow-up of 9 years. Overall survival remains significantly improved with the combination. So, in the ITT patient population, the intention-to-treat, the hazard ratio for overall survival was 0.71. So, this translates to a 29% reduction in the risk of death. 31% of patients were alive at this 108-month follow-up compared to 20% only in those who got sunitinib. So, similar benefits were observed in the intermediate- and poor-risk groups with a hazard ratio of 0.69, and 30% versus 19% survival at 108 months.  Importantly, a delayed benefit was also seen in those favorable-risk patients. So, the hazard ratio for overall survival improved from 1.45 in the initial report and now at 0.8 at 9 years follow-up, with 35% of patients alive at 108 months compared to 22% in those who got sunitinib. Progression-free survival also favored the nivo-ipi arm across all risk groups. At 96 months, the probability of remaining progression-free was about 23% compared to 9% in the sunitinib arm in the ITT patient population, 25% versus 9% in the intermediate- and poor-risk patients, and 13% compared to 11% in the favorable-risk patients. Importantly, at 96 months, 48% of patients in the nivo-ipi responders remained in response compared to just 19% in those who got sunitinib. And in the favorable-risk group, 36% of patients who responded remained in response, although data were not available for sunitinib in this subgroup.  So, this data reinforces the use of nivolumab and ipilimumab as a durable and effective first-line effective strategy for standard of care across all risk groups for advanced renal cell carcinoma. Dr. Neeraj Agarwal: Thank you, Jeanny. And of course, since ipi-nivo data were presented, several other novel ICI-TKI combinations have emerged. And I'm really hoping to see very similar data with TKI-ICI combinations down the line. It is really important to note that we are not seeing any new safety signals with the ICI combinations or ICI-based therapies, which is very reassuring given the extended exposure. Dr. Jeanny Aragon-Ching: Absolutely agree with you there, Neeraj.  Now, going on and moving on to Abstract 4514, which is the KEYNOTE-564 trial, and they reported on the 5-year outcomes of adjuvant pembrolizumab in clear cell RCC in patients who are at high risk for recurrence. Can you tell us a little bit more about this abstract, Neeraj? Dr. Neeraj Agarwal: Sure. So, the KEYNOTE-564 trial established pembrolizumab monotherapy as the first adjuvant regimen to significantly improve both disease-free survival and overall survival compared to placebo after surgery for patients with clear cell renal cell carcinoma. So, Dr Naomi Haas presented the 5-year update from this landmark trial.  A total of 994 patients were randomized to receive either pembrolizumab or placebo. The median follow-up at the time of this analysis was approximately 70 months. Disease-free survival remained significantly improved with pembrolizumab. The median DFS was not reached with pembrolizumab compared to 68.3 months with placebo, with a hazard ratio of 0.71, translating to a 29% reduction in risk of recurrence. At 5 years, 60.9% of patients receiving pembrolizumab remained disease-free compared to 52.2% with placebo. Overall survival also favored pembrolizumab. The hazard ratio for OS was 0.66, translating to a 34% reduction in risk of death, with an estimated 5-year overall survival rate of 87.7% with pembrolizumab compared to 82.3% for placebo. Importantly, these benefits were consistent across all key subgroups, including patients with sarcomatoid features. In addition, no new serious treatment-related adverse events have been reported in the 3 years since treatment completion.  So, these long-term data confirm pembrolizumab as a durable and effective standard adjuvant therapy for patients with resected, high-risk clear cell renal cell carcinoma. Dr. Jeanny Aragon-Ching: Thank you for that wonderful summary, Neeraj. Dr. Neeraj Agarwal: That wraps up our kidney cancer highlights. Any closing thoughts, Jeanny, before we conclude? Dr. Jeanny Aragon-Ching: It's been so wonderful reviewing these abstracts with you, Neeraj. So, the 2025 ASCO Annual Meeting showcased a lot of transformative data across GU cancers, from first-in-class bispecifics to long-term survival in RCC. And these findings are already shaping our clinical practices. Dr. Neeraj Agarwal: I agree. And we have covered a broad spectrum of innovations in GU cancers with strong clinical relevance.  So, thank you, Jeanny, for joining me today and sharing your insights.  And thank you to our listeners for joining us. You will find links to the abstracts discussed today in the transcript of this episode. If you find these conversations valuable, please take a moment to rate, review, and subscribe to the ASCO Daily News Podcast wherever you listen. Thank you so much. Disclaimer: The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions.  Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement. Find out more about today's speakers:    Dr. Neeraj Agarwal     @neerajaiims     Dr. Jeanny Aragon-Ching   Follow ASCO on social media:       @ASCO on Twitter       ASCO on Bluesky   ASCO on Facebook       ASCO on LinkedIn       Disclosures:   Dr. Neeraj Agarwal:   Consulting or Advisory Role: Pfizer, Bristol-Myers Squibb, AstraZeneca, Nektar, Lilly, Bayer, Pharmacyclics, Foundation Medicine, Astellas Pharma, Lilly, Exelixis, AstraZeneca, Pfizer, Merck, Novartis, Eisai, Seattle Genetics, EMD Serono, Janssen Oncology, AVEO, Calithera Biosciences, MEI Pharma, Genentech, Astellas Pharma, Foundation Medicine, and Gilead Sciences  Research Funding (Institution): Bayer, Bristol-Myers Squibb, Takeda, Pfizer, Exelixis, Amgen, AstraZeneca, Calithera Biosciences, Celldex, Eisai, Genentech, Immunomedics, Janssen, Merck, Lilly, Nektar, ORIC Pharmaceuticals, Crispr Therapeutics, Arvinas  Dr. Jeanny Aragon-Ching:   Honoraria: Bristol-Myers Squibb, EMD Serono, Astellas Scientific and Medical Affairs Inc., Pfizer/EMD Serono   Consulting or Advisory Role: Algeta/Bayer, Dendreon, AstraZeneca, Janssen Biotech, Sanofi, EMD Serono, MedImmune, Bayer, Merck, Seattle Genetics, Pfizer, Immunomedics, Amgen, AVEO, Pfizer/Myovant, Exelixis,    Speakers' Bureau: Astellas Pharma, Janssen-Ortho, Bristol-Myers Squibb, Astellas/Seattle Genetics

For more than 20 years, Ryan Worsley has been studiously, methodically, prodigiously, and obsessively honing his craft. Most recently, he was nominated by the Juno Awards for Recording Engineer of the Year (2020), but he was first recognized by the Western Canadian Music Awards in 2015 with his first award for Engineer of the Year. He has since won Producer of the Year twice (2019, 2022).Ryan's collaboration with Juno Award-winners Dear Rouge (Universal Music Canada) has been particularly fruitful. He produced, wrote, and mixed their LPs Black To Gold (2015), PHASES (2018), and Spirit (2022), resulting in five Top 10 singles on the Canadian Alternative Chart—including a #1 with “Fake Fame” in 2022.He also produced, co-wrote, and mixed Monowhales' Daytona Bleach, which earned four Top 10 singles on Canadian rock radio and contributed to the band's Juno Award for Breakthrough Group of the Year (2022).Ryan has worked with a wide range of artists, including Willow, Said The Whale (Arts & Crafts), Hotel Mira (Light Organ), Mathew V (604 Records), The Royal Foundry, and Shaun Frank.IN THIS EPISODE YOU'LL LEARN:Is knowing music theory problematic?Why it's a good thing to work with poor musiciansHow to keep objective when working multiple roles on a projectMaking songs grow and building excitementUnderstanding how radio affects your mixesAutomating your mix for impactBlending samples with real instrumentationAchieving natural dynamics in a songHow to pick samples efficientlyMaking your vocals feel controlled and polishedKnowing when to double vocalsHow to process layered vocalsUsing parallel processing on vocalsCompressing vocalsTo learn more about Ryan Worsley, visit https://www.echoplantsound.com/ryanLooking for 1-on-1 feedback and training to help you create pro-quality mixes?Check out my coaching program Amplitude and apply to join:https://masteryourmix.com/amplitude/ Want additional help with your music productions?For tips on how to improve your mixes, visit: https://masteryourmix.com/ Download your FREE copy of the Ultimate Mixing Blueprint: https://masteryourmix.com/blueprint/ Get your copy of my Amazon #1 bestselling books:The Recording Mindset: A Step-By-Step Guide to Creating Pro Recordings From Your Home Studio: https://therecordingmindset.com The Mixing Mindset: The Step-By-Step Formula For Creating Professional Rock Mixes From Your Home Studio: https://masteryourmix.com/mixingmindsetbook/ Check out our Sponsors:Download Waves Plugins here: https://waves.alzt.net/EK3G2K Subscribe to the show:Apple Podcasts: https://podcasts.apple.com/us/podcast/master-your-mix-podcast/id1240842781 Spotify: https://open.spotify.com/show/5V4xtrWSnpA5e9L67QcJej Youtube: http://www.youtube.com/@MasterYourMix...

Today, we cover ASCO 2025 in the genitourinary space, specifically bladder and renal cancer. Dr. Enrique Grande, a renowned oncologist and Program and Clinical Research lead of MD Anderson Cancer Centre, Madrid, joins us. This is a mega episode where we cover AMPLITUDE, JAVELIN MEDLEY, CHECKMATE 901 and NIAGARA, advancing urothelial cancer care; SEAR 02 and the CReST trial, pushing boundaries in bladder cancer; CHECKMATE 214; LITESPARK-005 and LITESPARK-004, showcasing belzutifan's promise; and KEYNOTE-564, adjuvant therapy for kidney cancer. Stay tuned for an insightful conversation on how these trials may be transforming patient outcomes!Studies discussed in the episode:CHECKMATE 901NIAGARACHECKMATE 214CREST trialSEAR 02LITESPARK 004/005AMPLITUDEJAVELIN MEDLEYFor more episodes, resources and blog posts, visit www.inquisitiveonc.comPlease find us on Twitter @InquisitiveOnc!If you want us to look at a specific trial or subject, email us at inquisitiveonc@gmail.comArt courtesy of Taryn SilverMusic courtesy of AlisiaBeats: https://pixabay.com/users/alisiabeats-39461785/Disclaimer: This podcast is for educational purposes only. If you are unwell, seek medical advice.Oncology for the Inquisitive Mind is recorded with the support of education grants from our foundation partners Pfizer, Gilead Pharmaceuticals and Merck Pharmaceuticals. Our partners have access to the episode at the same time you do and have no editorial control over the content. Hosted on Acast. See acast.com/privacy for more information.

Jordon Beal is a songwriter, producer, and engineer based in Chicago, IL. He made the leap into audio full-time in 2010 after working with legendary producer Sylvia Massy on a series of singles with his former band. Although his position in the band was uncertain, the studio experience sparked a deeper passion—he realized he felt far more fulfilled behind the glass than on stage. That moment became the catalyst for his career in audio.Since then, Jordon has built an impressive portfolio, working on records for artists such as Intervals (including their Juno Award-winning album), Silverstein, The Devil Wears Prada, Architects, Conquer Divide, Veil of Maya, Divide The Fall, Cane Hill, Janus, and LIMBS. His behind-the-scenes collaborations have also connected him with top-tier producers and engineers, including Sam Guaiana, Adam “Nolly” Getgood, Joey Sturgis, Sylvia Massy, and Phil Pluskota. In addition to production, he's carved out a niche in editing and session prep work—an area that now makes up a significant portion of his schedule and showcases his precision and attention to detail.IN THIS EPISODE YOU'LL LEARN:Working with Sylvia Massy as an artistHow to eliminate “red-light syndrome”Going with your gut instinctRecording keeper takes while writing songsMaking moves with intentAdjusting your processes to fit the artist's preferencesWhy double tracking with the same guitar can be problematicThe secret to getting your guitars to sound massiveWhy good editing starts at the tracking stageEditing guitars: Where you should make your cuts if you want the best soundThe pros and cons of time-stretchingUsing different time-stretching algorithmsUsing drum trigger spikes: Why they're so helpful Using Soundflow to save time and work efficientlyTo learn more about Jordon Beal, visit: https://www.facebook.com/jordon.poppLooking for 1-on-1 feedback and training to help you create pro-quality mixes?Check out my coaching program Amplitude and apply to join:https://masteryourmix.com/amplitude/ Want additional help with your music productions?For tips on how to improve your mixes, visit: https://masteryourmix.com/ Download your FREE copy of the Ultimate Mixing Blueprint: https://masteryourmix.com/blueprint/ Get your copy of my Amazon #1 bestselling books:The Recording Mindset: A Step-By-Step Guide to Creating Pro Recordings From Your Home Studio: https://therecordingmindset.com The Mixing Mindset: The Step-By-Step Formula For Creating Professional Rock Mixes From Your Home Studio: https://masteryourmix.com/mixingmindsetbook/ Check out our Sponsors:Download Waves Plugins here: https://waves.alzt.net/EK3G2K Subscribe to the show:Apple Podcasts: https://podcasts.apple.com/us/podcast/master-your-mix-podcast/id1240842781 Spotify: https://open.spotify.com/show/5V4xtrWSnpA5e9L67QcJej Youtube:

Today, we're joined by Professor Anthony Joshua, head of Medical Oncology at St. Vincent's Hospital, Sydney, and a global leader in prostate cancer and melanoma. In this episode, Professor Joshua discusses multiple trials including AMPLITUDE, advancing prostate cancer therapies; CAN 2409, exploring immunotherapy; ARANOTE, showing darolutamide's impact on progression-free survival; the prognostic significance of PSA 0.2; and the landmark STAMPEDE study. Join us for a deep dive into these game-changing studies. Let's begin! It's a jam-packed episode!Studies discussed in the episode:AMPLITUDECAN2409ARANOTESTAMPEDE*AND MORE!For more episodes, resources and blog posts, visit www.inquisitiveonc.comPlease find us on Twitter @InquisitiveOnc!If you want us to look at a specific trial or subject, email us at inquisitiveonc@gmail.comArt courtesy of Taryn SilverMusic courtesy of AlisiaBeats: https://pixabay.com/users/alisiabeats-39461785/Disclaimer: This podcast is for educational purposes only. If you are unwell, seek medical advice.Oncology for the Inquisitive Mind is recorded with the support of education grants from our foundation partners Pfizer, Gilead Pharmaceuticals and Merck Pharmaceuticals. Our partners have access to the episode at the same time you do and have no editorial control over the content. Hosted on Acast. See acast.com/privacy for more information.

Simon Grove is a music producer based in Sydney, Australia. Having an equally strong musical background as a bass player and guitarist, he is able to bridge the division between engineer and musician seamlessly. This allows him to create records with technical precision whilst retaining the music's intended character and dynamic. Simon has built a vast catalogue of clients from around the world, including Protest The Hero, Plini, Intervals, Richard Henshall, Stephen Taranto, Owane, Tashka, and many more.IN THIS EPISODE YOU'LL LEARN:Becoming a session musicianWhat makes a great bass tone?Using parallel processing on bassSimon's live and in-studio signal chains for bassKick and bass relationships: Deciding whether the bass should sit above or below the kick drumHow to shape your kick drums to fit the tempo of your songs (to get more clarity out of them)His plugin, GrovebassHow to make ghost notes be heard clearly in a mixGiving snare drums their own spaceHow the thickness of a drum affects the toneWhy he avoids using gates on drumsWhy editing is so important (even if you have great musicians and performances)Working on instrumental music: How to give lead guitars their own spaceTracking techniques for getting tighter guitarsThe importance of tuning for toneTo learn more about Simon Grove, visit: https://simongrove.com/Looking for 1-on-1 feedback and training to help you create pro-quality mixes?Check out my coaching program Amplitude and apply to join:https://masteryourmix.com/amplitude/ Want additional help with your music productions?For tips on how to improve your mixes, visit: https://masteryourmix.com/ Download your FREE copy of the Ultimate Mixing Blueprint: https://masteryourmix.com/blueprint/ Get your copy of my Amazon #1 bestselling books:The Recording Mindset: A Step-By-Step Guide to Creating Pro Recordings From Your Home Studio: https://therecordingmindset.com The Mixing Mindset: The Step-By-Step Formula For Creating Professional Rock Mixes From Your Home Studio: https://masteryourmix.com/mixingmindsetbook/ Check out our Sponsors:Want more Mixing or Mastering clients? Communicate your true value with MixFlip: https://mixflip.io/?affiliate=mym Download Waves Plugins here: https://waves.alzt.net/EK3G2K Subscribe to the show:Apple Podcasts: https://podcasts.apple.com/us/podcast/master-your-mix-podcast/id1240842781 Spotify: https://open.spotify.com/show/5V4xtrWSnpA5e9L67QcJej Youtube: http://www.youtube.com/@MasterYourMix Have questions you'd like answered on the show?Send them to

Gert Attard joins us to discuss this practice-changing data and the highlight of ASCO 2025

In this episode, Avanish and Andrew discuss:Andrew's journey as an "operational CFO" from Sun Microsystems through ServiceNow, WalkMe, Lacework, and now Amplitude, being part of the team that built ServiceNow from $400M to $4.5B ARRWhy CFOs must "play chess, not checkers" - thinking several moves ahead about decision implications and making strategic investment pivots for anticipated future growthThe critical difference between multi-product and platform strategies: true platforms have definite customer adoption journeys where products aren't sold independentlyRecognizing platform readiness signals: when customers organically create their own workflows and use cases you never conceived, like hospitals using Amplitude for emergency room optimizationBuilding effective teams by mixing "veterans with rookies" to solve problems rather than just "admire problems," and driving focused execution around single key investmentsThe "fair exchange of value" approach to pricing and partnerships that emphasizes customer adoption, transparency, and simplicity over complexityAbout Avanish Sahai:Avanish Sahai is a Tidemark Fellow and served as a Board Member of Hubspot from 2018 to 2023; he currently serves on the boards of Birdie.ai, Flywl.com and Meta.com.br as well as a few non-profits end educational boards. Previously, Avanish served as the vice president, ISV and Apps partner ecosystem of Google from 2019 until 2021. From 2016 to 2019, he served as the global vice president, ISV and Technology alliances at ServiceNow.  From 2014 to 2015, he was the senior vice president and chief product officer at Demandbase.  Prior to Demandbase, Avanish built and led the Appexchange platform ecosystem team at Salesforce, and was an executive at Oracle and McKinsey & Company, as well as various early-to-mid stage startups in Silicon Valley.About Andrew Casey: Andrew Casey is Chief Financial Officer at Amplitude, where he leads Amplitude's General & Administrative organization, which includes finance, accounting, and legal. With more than 25 years of enterprise software experience, Casey brings deep financial expertise combined with extensive go-to-market strategy and business operations experience.Casey joined Amplitude from Lacework, where he served as CFO and oversaw its successful acquisition by Fortinet. Prior to that, he was the CFO of WalkMe, where he led its Initial Public Offering (IPO) and transformed its enterprise sales motion. Casey's career also includes senior finance roles with ServiceNow, Hewlett-Packard, NortonLifeLock Inc. (formerly Symantec), Oracle, and Sun Microsystems.About TidemarkTidemark is a venture capital firm, foundation, and community built to serve category-leading technology companies as they scale.  Tidemark was founded in 2021 by David Yuan, who has been investing, advising, and building technology companies for over 20 years.  Learn more at www.tidemarkcap.com.LinksFollow our guest, Andrew CaseyFollow our host, Avanish SahaiLearn more about Tidemark

Eric Vishria is a General Partner at Benchmark Capital.Our conversation goes inside the new class of startups going zero to $100 million ARR in 12 months, the ways AI is changing company building, and how Eric and Benchmark make new investments.We get into the risk rewards of Series As today, how Benchmark competes to work with founders, and and why the best storytellers win.We also talk about parallels between the 90's, 2000's, and today, and how the archetype of successful founders has changed in the age of AI.Thanks to Spenser Skates, Sajith Wickramasekara, Bobby DeSimone, and Semil Shah for help brainstorming topics for Eric!Special thanks to this episode's sponsors:Bolt: Help them break a world record for the largest hackathon - up to $1m in prizes. Sign-up here. Numeral: The end-to-end platform for sales tax and compliance. Try it here.Timestamps:(5:17) What gets Eric excited about a new investment(7:48) Backing learning machines(12:34) Backing Cerebras at inception(16:20) Why the best storytellers win(21:17) How Eric works with founders(26:38) Companies going zero to $100m in 12 months(31:09) Revenue quality of AI products(32:41) Moats and business models in AI(38:41) AI margins and runway(41:14) Parallels between winners of the 90's and today(44:54) Archetypes of the best AI founders(50:43) SaaS companies successfully pivoting to AI(53:43) LLMs are most comparable to transistors in the 1950s(56:19) Ways Eric uses AI personally(58:05) How VC has changed over the past decade(1:01:40) VC is a hustler's business(1:03:20) Backing extraordinary companies is all that matters(1:09:36) What makes Benchmark unique(1:17:03) How Benchmark makes investment decisions(1:18:38) Skipping senior year of high school(1:20:21) Working with Ben Horowitz and Marc Andreessen ‘00-'08(1:24:42) Starting RockMelt, selling to Yahoo(1:26:28) Joining Benchmark in 2014(1:28:08) Investing in Confluent one month later(1:28:50) Lessons from Spenser at Amplitude(1:29:36) Fireworks AI's hyper growth(1:30:49) Pricing in AI changing from tokens to outcomes(1:32:23) Ways Eric's perception of VCs changed after becoming one(1:34:07) How to build a management team(1:38:21 )The best CEOs make new mistakes(1:39:50) Why there should be more public companies(1:44:03) “Even great companies can be overvalued”ReferencedBenchmarkCerebrasBenchlingBen Thompson + Mark Zuckerberg InterviewConfluentAmplitudeFireworks AIAndy Price at Artisinal TalentFollow EricX / TwitterLinkedInFollow TurnerX/ TwitterLinkedInSubscribe to my newsletter to get every episode + the transcript in your inbox every week

A classically trained guitarist who studied composition at The New School for Jazz and Contemporary Music, Manhattan native Ben Greenberg is a prolific record producer, engineer, songwriter, and performer who coheres conservatory training with a deep history across many different genres of underground music.Known as a founding member of respected industrial/metal group Uniform and a former member of The Men, Zs, and many more, Greenberg has been described by Ben Ratliff of the New York Times as “a good musician [...] and boss of his own one-man guitar project, Hubble.” Ben's rich and varied performance history ranges from over two decades touring with bands to performing for legendary composers like Glenn Branca and Terry Riley.In the year 2000 Greenberg began assisting Grammy-award winning engineer Mike Marciano at Systems Two Recording in Ditmas Park, Brooklyn. It was here that he learned the fundamentals of recording on 2” tape alongside early Pro Tools systems. He would go on to build his own recording studio in Brooklyn (Python Patrol) and work out of world-class studios all around the globe (Electrical Audio, The Magic Shop, Strange Weather, The Pool, Sonic Ranch). Greenberg's studio credits include Danny Elfman, Depeche Mode, Drab Majesty, Wicca Phase Springs Eternal, Junglepussy, Show Me The Body, Drew McDowall, Black Marble, and Christeene, among many others. His process attends to the essence of the artist's vision and exacts a cultivated philosophy of sound upon them. The result is something between organic and synthetic: A magic that locks in the music's emotional resonance with the listener.Since the 2010s, Greenberg has produced and mixed award-winning scores for film and television. He is the principal engineer to the scores of composer Brian McComber (ex-Dirty Projectors), including the A24 productions It Comes At Night and Krisha, as well as Kingdom of Silence (Showtime), 16 Shots (Showtime), Little Woods (Neon), Mickey and The Bear (Utopia), and Fair Play (Netflix), among others. Greenberg was Randall Dunn's mix assistant for the Jóhann Jóhannsson score to Panos Cosmatos' 2018 film, Mandy (SpectreVision), and Dunn's co-engineer for the 2022 score to Julio Torres' Problemista (A24). Greenberg has also mixed Ella Van Der Woude's scores for Something You Said Last Night (Elevation Pictures) and Silver Haze (EMU Films), and in 2024 he won a Cinema Audio Society award for Outstanding Achievement in Sound Mixing - Documentary, for his stereo and surround mixes of JD Samson's score for Sam Green's 32 Sounds (DofMP).IN THIS EPISODE YOU'LL LEARN:Starting music production at a young ageFinding jobs in the music industryDealing with parents who might not understand your passionsWorking on metal, jazz, and everything in betweenSwitching your workflow for different genresUnderstanding what to listen for with compressionHow to approach a new mixWhy volume and panning are your most important toolsDetermining when plugins are worth purchasing Working with Danny ElfmanPurposely doing lessTo learn more about Ben Greenberg, visit: https://circularruin.com/Ben-GreenbergLooking for 1-on-1 feedback and training to help you create pro-quality mixes?Check out my coaching program Amplitude and apply to join:https://masteryourmix.com/amplitude/ Want additional help with your music productions?For tips on how to improve your mixes, visit: https://masteryourmix.com/ Download your FREE copy of the Ultimate Mixing Blueprint:

Dr. John Sweetenham shares highlights from Day 5 of the 2025 ASCO Annual Meeting, including data from large trials in advanced malignant melanoma and mCSPC plus a new approach to first-line treatment for patients with multiple myeloma who are not transplant eligible. Transcript Hello, I'm Dr. John Sweetenham, the host of the ASCO Daily News Podcast, with my takeaways on selected abstracts from Day 5 of the 2025 ASCO Annual Meeting. My disclosures are available in the transcript of this episode. The selected abstracts from this final day of ASCO25 include important new data from large, randomized trials in patients with advanced malignant melanoma and patients with metastatic castration-sensitive prostate cancer, as well as a new approach to the first-line treatment of patients with multiple myeloma who are not transplant eligible.  Starting with LBA9500, this study was conducted in patients with completely resected stage III or IV malignant melanoma and compared the combination of relatlimab plus nivolumab versus nivolumab alone in this population. The study, named the RELATIVITY-098 trial, was presented by Dr. Georgina Long from the University of Sydney, Australia. In her introduction to the study, Dr. Long explained that the current standard of care for adjuvant therapy of resected stage III/IV melanoma is with PD-1 monotherapy with nivolumab, but that about 50% of patients will suffer from a subsequent relapse. In the first-line setting in patients with advanced or unresectable melanoma, the combination of nivolumab with the LAG-3 inhibitor, relatlimab, has been previously shown to improve progression-free survival in the RELATIVITY-047 trial. The current study evaluated this same combination in the adjuvant setting. More than 1,000 patients from 24 countries were randomized to receive either nivolumab alone (546 patients) or the combination of nivolumab with relatlimab (547 patients). Both treatments were given for a maximum of 1 year or until progression of disease, unacceptable toxicity, withdrawal, or death. Various biomarker studies were also undertaken including LAG-3 and PD-1 expression on CD8-positive T cells. The primary endpoint of the study was relapse-free survival, and Dr. Long reported that this was the same in both arms of the study. For example, at 24 months, the relapse-free survival was 64% in the monotherapy arm compared with 62% in the combination arm. The hazard ratio was 1.01 and the P value was 0.928. Metastasis-free survival was also identical in both arms. No benefit was observed for the combination in any of the prespecified subgroups. No new toxicity signals emerged compared with the RELATIVITY-047 trial. Interestingly, the baseline surface expression of LAG-3 and co-expression of LAG-3 and PD-1 on CD8 T cells in the 098 adjuvant trial were lower than in the 047 advanced disease trial, perhaps explaining why the combination did not confer benefit over nivo alone in the adjuvant setting. This is an important result, demonstrating that results from one clinical setting cannot always be extrapolated to another. Although the combination has gained some use in the adjuvant setting, this study clearly demonstrates that more drug in this situation is no better and that monotherapy remains the current standard of care. Results from the AMPLITUDE trial for patients with metastatic castration-sensitive prostate cancer with alterations in homologous recombination repair (HRR) genes, in LBA5006, were presented today by Dr. Gerhardt Attard from University College London, UK. This international, multicenter study evaluated the combination of the selective PARP inhibitor, niraparib, in combination with abiraterone acetate and prednisone. The same combination has been previously shown to improve outcomes in castration-resistant metastatic prostate cancer harboring BRCA mutations in the MAGNITUDE study. The current trial included patients with castration-sensitive disease with HRR mutations including BRCA1/2. Six hundred and ninety-six patients were randomized between niraparib, abiraterone, and prednisone plus androgen deprivation therapy, or the same combination with placebo instead of niraparib. Permitted prior therapies included no more than 6 months of prior androgen deprivation therapy and the use of docetaxel, or prior palliative radiation therapy. The primary endpoint of the study was radiographic relapse-free survival. Dr. Attard reported that the risk for radiographic progression-free survival in the whole population was significantly reduced by 37% with niraparib and abiraterone acetate plus prednisone compared with the placebo arm. The radiographic progression-free survival risk reduction with niraparib in the prespecified BRCA1/2 subgroup was 48% and reached statistical significance compared with the placebo arm. The secondary endpoint of time to symptomatic progression was also improved with niraparib in the HRR population and the BRCA1/2 subgroup. There was a trend for overall survival favoring the niraparib combination. However, the overall survival data were immature at this first interim analysis and did not yet reach statistical significance. No new safety concerns emerged with the toxicity data consistent with the MAGNITUDE study. Less than 5% more of the patients on the experimental arm discontinued treatment in comparison to the control arm. The authors conclude that the AMPLITUDE study results support the use of niraparib, abiraterone, and prednisone as a new treatment option for patients with metastatic castration- sensitive prostate cancer and BRCA and homologous recombination repair gene alterations. The results certainly support this conclusion and are potentially practice-changing. Turning to hematologic malignancies, my final selection from today's presentations is Abstract 7504, presented by Dr. Hang Quach from St Vincent's Hospital, Melbourne, Australia, and describes a novel combination of elranatamab, daratumumab, and lenalidomide in patients with newly diagnosed multiple myeloma who are not transplant-eligible – the so-called MagnetisMM-6 trial part 1. Elranatamab is a novel bispecific T-cell engaging antibody directed against BCMA and CD3, which has previously been approved for certain patients with relapsed and refractory multiple myeloma. In the present study, this was combined with lenalidomide and daratumumab in newly diagnosed patients. The report today describes the dose-finding phase of this study, which was part 1, specifically addressing so-called dose level ‘G', comprising elranatamab 76mg subcutaneously every 4 weeks plus daratumumab 1800mg subcutaneously and lenalidomide 25mg given orally. Thirty-seven patients were entered at this dose level, of whom 32 were on treatment at the time of analysis. Early response data show an overall response rate of 97.3%. With median follow up of 7.9 months, the current CR rate is 27% with a VGPR rate of almost 68%. The most frequent toxicities were hematologic, with neutropenia observed in 75%. Some cytokine release syndrome was observed in about 60% of patients, but none was greater than grade 2. The authors conclude that this combination is active in untreated multiple myeloma, with manageable toxicity and evidence of responses which appear to deepen over time. The dose-finding component of this trial is continuing and will subsequently progress into a phase 3 trial based on the data from the current study. This will compare daratumumab plus lenalidomide with the same combination plus elranatamab in previously untreated patients. That concludes our special coverage from the 2025 ASCO Annual Meeting. Thanks for listening and we hope you have enjoyed listening to our top takeaways from ASCO25. If you value the insights that you hear on the ASCO Daily News Podcast, please remember to rate, review, and subscribe wherever you get your podcasts. Disclaimer:  The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement.  Find out more about today's speaker:    Dr. John Sweetenham    Follow ASCO on social media:     @ASCO on Twitter    @ASCO on Bluesky    ASCO on Facebook    ASCO on LinkedIn     Disclosures:   Dr. John Sweetenham:    No relationships to disclose

Mike Pepe is an L.A.-based producer/songwriter, outstanding in the alternative scene with crossover appeal. Recent releases and sessions include The Struts, Charlotte Sands, Taking Back Sunday, Mod Sun, Cassadee Pope, Bryce Vine, Plain White T's, Matty Healy, and Dashboard Confessional. Notable syncs include EA NHL 25, Keeping Up with the Kardashians, and Ball and the Family. He has a talent for developing indies and helping get them label deals, most recently Senses (Hopeless Records) and Diva Bleach (Thriller Records). Regular writing and production partners include Lil Aaron, Imad Royal, Ilan Rubin, The Futuristics, Mitchy Collins, Curtis Peoples, Blaise Railey, Kate Morgan, and Smrtdeath, among many others.IN THIS EPISODE YOU'LL LEARN:Working with John FeldmanHow to keep tracks interestingBeing tested throughout your careerChallenging yourself to write bad songs on purposeThe challenges of being a songwriter professionallyBeing a songwriter, without music theory trainingThe skills of a great producerProducers vs. songwritersBeing pigeonholeed by your successesHow to empower the artists you work with Thinking based on feeling, rather than being technically mindedMaking choruses feel giantTo learn more about Mike Pepe, visit https://www.mikepepemusic.com/Looking for 1-on-1 feedback and training to help you create pro-quality mixes?Check out my coaching program Amplitude and apply to join:https://masteryourmix.com/amplitude/ Want additional help with your music productions?For tips on how to improve your mixes, visit: https://masteryourmix.com/ Download your FREE copy of the Ultimate Mixing Blueprint: https://masteryourmix.com/blueprint/ Get your copy of my Amazon #1 bestselling books:The Recording Mindset: A Step-By-Step Guide to Creating Pro Recordings From Your Home Studio: https://therecordingmindset.com The Mixing Mindset: The Step-By-Step Formula For Creating Professional Rock Mixes From Your Home Studio: https://masteryourmix.com/mixingmindsetbook/ Check out our Sponsors:Download Waves Plugins here: https://waves.alzt.net/EK3G2K Subscribe to the show:Apple Podcasts: https://podcasts.apple.com/us/podcast/master-your-mix-podcast/id1240842781 Spotify: https://open.spotify.com/show/5V4xtrWSnpA5e9L67QcJej Youtube: http://www.youtube.com/@MasterYourMix Have questions you'd like answered on the show?Send them to questions@masteryourmix.comPlease leave a rating and review:https://masteryourmix.com/review/ Thanks for listening!

Serving SMB mid-market customers is one thing, but when you go upstream to enterprise sales, everything changes: go-to-market strategy, the sales process, how you structure deals, even how you define customer value. Today's guest, Andrew Casey, has helped scale four SaaS companies: ServiceNow, WalkMe, Lacework, and his current company, Amplitude. At ServiceNow, he worked closely with Snowflake's Mike Scarpelli and Coatue's David Schneider, and he was instrumental in establishing the company's deal desk to support its sales motion. As an operationally focused CFO, he shares a wealth of knowledge on the importance of staying close to the customer, structuring deals that work for both sides, establishing transparency in usage-based pricing, aligning incentives and strategy in sales, the pros and cons of multi-year deals, the problem with auto-renewals and what to do instead, and how to adapt your go-to-market strategy when moving from SMB mid-market to enterprise.—LINKS:Andrew Casey on LinkedIn: https://www.linkedin.com/in/andrew-casey-6b14875/Amplitude: https://amplitude.comServiceNow: https://www.servicenow.comCJ on X (@cjgustafson222): https://x.com/cjgustafson222Mostly metrics: http://mostlymetrics.comRELATED EPISODES:Gaining Strategic Advantage in Vertical SaaS With Guidewire's CFO, Jeff Cooper"Steal Your Boss's Job”: Calendly CFO John McCauley on Leadership, Ownership & GrowthThe Largest Software IPO Ever: How Snowflake Still Left Money on the Table —TIMESTAMPS:(00:00) Preview and Intro(02:40) Sponsor – Tropic | NetSuite | Planful | Tabs(08:45) Becoming an Operationally Focused CFO(11:50) Staying Close to the Customer as a CFO(16:37) Sponsor – Rippling Spend | Pulley | MUFG(20:34) Running Towards a Challenging Market at ServiceNow(24:15) How He Established the Deal Desk at ServiceNow(26:13) Structuring a Deal That Works for Both Sides(29:08) Transparency in Usage-Based Pricing(32:39) A Client's “Budget Problem”: Cash or Expense Issue(36:42) Lessons From Building Out the Deal Desk at ServiceNow(40:53) Pros and Cons of Multi-Year Deals(43:57) Auto-Renewals: Do This Instead(46:10) Adapting the Go-to-Market Strategy for Enterprise Sales(55:33) Selling to CIOs Whose Jobs Are at Stake(58:18) What Defines “Enterprise”(59:43) The Most Important Thing To Get Right in Enterprise Sales(1:01:01) Lessons From Andrew's Background in Corporate Finance(1:03:12) The Story of How Andrew Got His Job at ServiceNow(1:07:57) Long-Ass Lightning Round: A Big Mistake(1:10:31) Advice to Younger Self(1:11:17) Finance Software Stack(1:14:47) Craziest Expense Story—SPONSORS:Tropic is an intelligent spend management solution that consolidates your spend data and processes into one unified offering, enabling insights and decisive action. Take control of your spend with intelligent spend management at tropicapp.io/mostlymetrics.NetSuite is an AI-powered business management suite, encompassing ERP/Financials, CRM, and ecommerce for more than 41,000 customers. If you're looking for an ERP, head to https://netsuite.com/metrics and get the CFO's Guide to AI and Machine Learning.Planful's financial planning software can transform your FP&A function. Built for speed, accuracy, and confidence, you'll be planning your way to success and have time left over to actually put it to work. Find out more at www.planful.com/metrics.Tabs is a platform that brings all of your revenue-facing data and workflows - billing, AR, payments, rev rec, and reporting - onto a single system so you can automate and be more flexible. Find out more at: tabs.inc/metrics.Rippling Spend is a spend management software that gives you complete visibility and automated policy controls across every type of spend, saving you time and money. Get a demo to see how much time your org would save at rippling.com/metrics.Pulley is the cap table management platform built for CFOs and finance leaders who need reliable, audit-ready data and intuitive workflows, without the hidden fees or unreliable support. Switch in as little as 5 days and get 25% off your first year: pulley.com/mostlymetrics.MUFG is a global banking powerhouse that provides comprehensive banking services for VC-backed, PE-backed, and public companies with revenues starting at $40M. Accelerate your growth trajectory. Contact group head Bob Blee at bblee@us.mufg.jp to find out more.#SMBtoEnterprise, #gotomarketstrategy #scalingSaaS #dealdesk #ServiceNow Get full access to Mostly metrics at www.mostlymetrics.com/subscribe

Anne is the Head Engineer/Producer at La La Land Sound in Louisville, Kentucky. She has split her time between Montreal and Louisville over the last 10 years, working on hundreds of recordings along the way, gathering over 375 million streams.​​She spends most of her time in the studio, recording, mixing, and producing with artists like Murder By Death, Bonnie Prince Billy, GRLwood, Joan Shelley, Strand of Oaks, By the Grace of God, and Rachel Grimes. She's also worked on albums by Ray Lamontagne, Jake Shears, Emma Ruth Rundle, and White Reaper over the years. Bumping shoulders over time working with producers Glyn Johns, John Alagia, and Jim James. She's recorded, mixed, and/or produced more than 100 records in her career, with records gathering reviews in publications such as Rolling Stone, Nylon, Billboard, NPR, Brooklyn Vegan, Kerns, AVClub, Magnet, and most major music publications. Anne is a true professional in experience, efficiency, and creative thinking, and loves to foster a positive and friendly recording experience for all. She enjoys and is specialized in old school live band recordings as much as complex multi-month modern productions and is skilled in both approaches. She loves working with artists on all styles of music: rock, country, experimental, contemporary, classical, and everything in between.IN THIS EPISODE YOU'LL LEARN:Recording yourself vs othersStarting before you truly feel “ready”Working on multiple projects quickly vs taking your time on one project: Which will help you grow faster?Minimal mic technique compared to multi-micingWhy having a mobile rig is super helpful for people just getting startedGetting the most out of sub-par roomsChoosing mics that suit the roomBuilding your mental library of studio gearWorking with Glynn JohnsHow the famed Glynn Johns technique was actually an accidentRemixing Slint's “Tweez” (previously mixed by Steve Albini)Using AI for audio restorationTo learn more about Anne Gauthier, visit: https://www.annegauthier.info/Looking for 1-on-1 feedback and training to help you create pro-quality mixes?Check out my coaching program Amplitude and apply to join:https://masteryourmix.com/amplitude/ Want additional help with your music productions?For tips on how to improve your mixes, visit: https://masteryourmix.com/ Download your FREE copy of the Ultimate Mixing Blueprint: https://masteryourmix.com/blueprint/ Get your copy of my Amazon #1 bestselling books:The Recording Mindset: A Step-By-Step Guide to Creating Pro Recordings From Your Home Studio: https://therecordingmindset.com The Mixing Mindset: The Step-By-Step Formula For Creating Professional Rock Mixes From Your Home Studio: https://masteryourmix.com/mixingmindsetbook/ Check out our Sponsors:Download Waves Plugins here: https://waves.alzt.net/EK3G2K Subscribe to the show:Apple Podcasts: https://podcasts.apple.com/us/podcast/master-your-mix-podcast/id1240842781 Spotify:

Mike Kennerty has been playing guitar for the All-American Rejects for more than a couple decades at this point. When he's not doing that he's busy working as a producer/mixer/engineer for bands such as Screeching Weasel, Masked Intruder, The Copyrights, Red City Radio, Direct Hit, Geoff Palmer, etc... He lives in Oklahoma and actually quite enjoys it!IN THIS EPISODE YOU'LL LEARN:Building confidence as an audio engineerTaking chances to land clientsWorking with and learning from producers such as Howard Benson, Matt Squire, and Eric ValentineShaping songs in pre-productionWriting “hit” songsRefining a band's soundSeeing your limitations as a superpowerIncorporating templates into your processUsing room samples vs reverbsHis workflow for working with programmed drumsKeeping guitar tracking simpleUsing room tracks with guitarsTo learn more about Mike Kennerty, visit: https://www.instagram.com/mikeaar/Looking for 1-on-1 feedback and training to help you create pro-quality mixes?Check out my coaching program Amplitude and apply to join:https://masteryourmix.com/amplitude/ Want additional help with your music productions?For tips on how to improve your mixes, visit: https://masteryourmix.com/ Download your FREE copy of the Ultimate Mixing Blueprint: https://masteryourmix.com/blueprint/ Get your copy of my Amazon #1 bestselling books:The Recording Mindset: A Step-By-Step Guide to Creating Pro Recordings From Your Home Studio: https://therecordingmindset.com The Mixing Mindset: The Step-By-Step Formula For Creating Professional Rock Mixes From Your Home Studio: https://masteryourmix.com/mixingmindsetbook/ Check out our Sponsors:Download Waves Plugins here: https://waves.alzt.net/EK3G2K Subscribe to the show:Apple Podcasts: https://podcasts.apple.com/us/podcast/master-your-mix-podcast/id1240842781 Spotify: https://open.spotify.com/show/5V4xtrWSnpA5e9L67QcJej Youtube: http://www.youtube.com/@MasterYourMix Have questions you'd like answered on the show?Send them to questions@masteryourmix.comPlease leave a rating and review:https://masteryourmix.com/review/ Thanks for listening!

Gregory Scott is an audio engineer, mixer, and record producer from Los Angeles, California. Immersed in music from the age of 4, he has grown up with a deep passion for crafting sound. In 2020, he co-founded Off-Center Records with fellow engineer-producer Aaron Moxness to bridge the gap between indie artists and the technical, creative, and promotional resources available in the Los Angeles music scene.Gregory's technical expertise is grounded in a Bachelor's in Recording Arts from Loyola Marymount University. During and after his college years, he refined his craft at prestigious studios like Morning View and Westlake Recording Studios. At Westlake, he contributed to Grammy-winning projects such as Tyler, the Creator's Call Me If You Get Lost and collaborated with major talents like SZA, Dominic Fike, and Benny Blanco, among countless others.As a producer, Gregory partners with artists to discover and fine-tune their unique sound, helping them create cohesive and authentic bodies of work. His extensive industry knowledge and versatile skill set allow him to support artists at every stage of their journey, enabling them to focus on creating. This has led him to work on the latest releases of artists like JMSN, Snakehips, Riz la Vie, and Mad Keys, and help launch fresh-faced artists like Cam Okoro, Eli Feier, and MAMA, I'M into the next phase of their career.IN THIS EPISODE YOU'LL LEARN:The differences between small and big studiosUsing the same approaches when working between various genresFinding time to practice your audio skillsDeveloping the sound of an artistDo track lengths matter?Writing for TikTokFocusing on the musical hierarchy in a mixWhy you should layer reverbsPicking complementary reverbsWorking with reverb timesNavigating the idea of “perfect” vs “done”How to determine when an imperfection is ok to leave in a mixUsing tools to help with achieving the overall frequency balance of the mixWhy tools like Tonal Balance Control can be problematicTo learn more about Gregory Scott, visit: https://www.gregsoundsgood.com/Looking for 1-on-1 feedback and training to help you create pro-quality mixes?Check out my coaching program Amplitude and apply to join:https://masteryourmix.com/amplitude/ Want additional help with your music productions?For tips on how to improve your mixes, visit: https://masteryourmix.com/ Download your FREE copy of the Ultimate Mixing Blueprint: https://masteryourmix.com/blueprint/ Get your copy of my Amazon #1 bestselling books:The Recording Mindset: A Step-By-Step Guide to Creating Pro Recordings From Your Home Studio: https://therecordingmindset.com The Mixing Mindset: The Step-By-Step Formula For Creating Professional Rock Mixes From Your Home Studio: https://masteryourmix.com/mixingmindsetbook/ Check out our Sponsors:Want more Mixing or Mastering clients? Communicate your true value with MixFlip: https://mixflip.io/?affiliate=mym Download Waves Plugins here: https://waves.alzt.net/EK3G2K...

Anthony “Rocky” Gallo is a Grammy-winning producer/recording engineer based in Brooklyn. Rocky has worked with artists such as Cigarettes After Sex, John Legend, Common, Norah Jones, Gavin DeGraw, Cat Power, Yeasayer, Mos Def, Carly Simon, Jon Bon Jovi, Perry Farrell, Warren Haynes, Travis Barker, Robert Randolph, Jim Jones, KRS1, Talib Kweli and many more. His achievements include a Grammy, Platinum records, and billions of streams. Rocky is constantly producing artists himself and is always excited to work in all music genres. Rocky runs Virtue And Vice Studios located in Brooklyn, featuring a Vintage 8026 Neve Console loaded with 1084's. When he is not freelancing at other studios, it is his primary home.IN THIS EPISODE YOU'LL LEARN:Being “all-in” regardless of tough timesBuilding your studio project by projectFinding your true calling in audio productionWorking on high-pressure projectsLosing objectivity by mixing for too longNot taking mix revision notes personallyDeveloping consistency with the quality of your workSaving time with templatesEffectively using reverbs in your mixesWhy overcompressing is actually a good thingTo learn more about Anthony “Rocky” Gallo, visit: http://www.tjgallo.com/Looking for 1-on-1 feedback and training to help you create pro-quality mixes?Check out my coaching program Amplitude and apply to join:https://masteryourmix.com/amplitude/ Want additional help with your music productions?For tips on how to improve your mixes, visit: https://masteryourmix.com/ Download your FREE copy of the Ultimate Mixing Blueprint: https://masteryourmix.com/blueprint/ Get your copy of my Amazon #1 bestselling books:The Recording Mindset: A Step-By-Step Guide to Creating Pro Recordings From Your Home Studio: https://therecordingmindset.com The Mixing Mindset: The Step-By-Step Formula For Creating Professional Rock Mixes From Your Home Studio: https://masteryourmix.com/mixingmindsetbook/ Check out our Sponsors:Want more Mixing or Mastering clients? Communicate your true value with MixFlip: https://mixflip.io/?affiliate=mym Download Waves Plugins here: https://waves.alzt.net/EK3G2K Subscribe to the show:Apple Podcasts: https://podcasts.apple.com/us/podcast/master-your-mix-podcast/id1240842781 Spotify: https://open.spotify.com/show/5V4xtrWSnpA5e9L67QcJej Youtube: http://www.youtube.com/@MasterYourMix Have questions you'd like answered on the show?Send them to questions@masteryourmix.comPlease leave a rating and review:

ABOUT WADE CHAMBERSWade Chambers will be leading Engineering at Amplitude. Amplitude is the leading digital analytics platform that helps companies unlock the power of their products. Wade has over 25 years of engineering leadership experience, both advising companies and being hands-on in key leadership positions at companies such as Included Health, Twitter, TellApart, Proofpoint, Yahoo, and Opsware. He is a deep technical expert with a proven track record of scaling teams, leaders, market-defining technology innovations, and business growth. Build AI Voice Agents with ElevenLabsElevenLabs is the leading Voice AI platform for developers with thousands of ultra-realistic, human-like voices across 32 languages.Developers use ElevenLabs to build life-like, conversational AI voice agents to handle customer support queries, appointment scheduling, and even offer personalized 1-1 tutoring.Get started for free at elevenlabs.io/elc SHOW NOTES:Why empowering engineering teams to own their mission matters (3:16)Common traps that prevent eng leaders from empowering teams (5:15)Understanding the “why” behind ownership & systemizing individual ownership (7:09)Systems change for empowerment: Aligning company vision, outcomes, competencies & behaviors (9:48)How to bring someone from low ownership back to high ownership (13:49)Developing trust & having tough conversations around ownership (15:17)Nonobvious factors to that erode ownership over time (17:42)Empowering teams through meaningful missions, clear expectations, defining success, & ongoing check-ins (20:55)Identifying engineers w/ competencies & behaviors that align w/ your org's vision & goals (24:00)When having too much ownership becomes a problem (27:22)Wade's process for officially transferring ownership (28:47)Coaching and navigating conversations around ownership (32:01)Impactful questions to ask during the coaching / check in process (34:08)Closing gaps in leadership competencies & behaviors (37:27)Coaching leaders to align personal growth with org goals (39:25)Rapid fire questions (41:34)This episode wouldn't have been possible without the help of our incredible production team:Patrick Gallagher - Producer & Co-HostJerry Li - Co-HostNoah Olberding - Associate Producer, Audio & Video Editor https://www.linkedin.com/in/noah-olberding/Dan Overheim - Audio Engineer, Dan's also an avid 3D printer - https://www.bnd3d.com/Ellie Coggins Angus - Copywriter, Check out her other work at https://elliecoggins.com/about/

Andy Gesner is the owner and president of HIP Video Promotion. He has played in bands and released records since 1979, giving him firsthand insight into the music industry's complexities. This experience as a working musician informs his authentic approach to music promotion and marketing. He channeled his expertise and passion into uplifting fellow artists, establishing HIP as one of the most trusted names in music marketing. Over the past 24 years, he has built HIP from the ground up, developing innovative promotional strategies that adapt to the ever-changing media landscape. Andy and his team have promoted more than 4,800 music videos for artists including Bryan Adams, The B-52s, Bon Iver, Johnny Cash, Death Cab For Cutie, Pearl Jam, Maroon 5, Sia, and Weird Al Yankovic, spanning genres from indie rock to hip-hop, pop, metal, and beyond.IN THIS EPISODE YOU'LL LEARN:Making friends instead of competitorsImmersing yourself in your local sceneNavigating the 80/20 of album marketingPutting together a marketing teamBuying fake followers, comments, and likesCreating music videos vs short-form contentRepackaging your workWhy videos are so important for your music promotionHaving consistency in your marketingHow much to budget for album promotionHis experiences working with artists like Johnny Cash, Maroon 5, Sia, The Lumineers, Paramore, and moreGiving your audience calls to actionWhat metrics to pay attention to to know if your marketing is workingTo learn more about Andy Gesner, visit: https://www.hipvideopromo.com/Looking for 1-on-1 feedback and training to help you create pro-quality mixes?Check out my coaching program Amplitude and apply to join:https://masteryourmix.com/amplitude/ Want additional help with your music productions?For tips on how to improve your mixes, visit: https://masteryourmix.com/ Download your FREE copy of the Ultimate Mixing Blueprint: https://masteryourmix.com/blueprint/ Get your copy of my Amazon #1 bestselling books:The Recording Mindset: A Step-By-Step Guide to Creating Pro Recordings From Your Home Studio: https://therecordingmindset.com The Mixing Mindset: The Step-By-Step Formula For Creating Professional Rock Mixes From Your Home Studio: https://masteryourmix.com/mixingmindsetbook/ Check out our Sponsors:Want more Mixing or Mastering clients? Communicate your true value with MixFlip: https://mixflip.io/?affiliate=mym Download Waves Plugins here: https://waves.alzt.net/EK3G2K Subscribe to the show:Apple Podcasts: https://podcasts.apple.com/us/podcast/master-your-mix-podcast/id1240842781 Spotify: https://open.spotify.com/show/5V4xtrWSnpA5e9L67QcJej Youtube: http://www.youtube.com/@MasterYourMix Have questions you'd like...

Amplitude helped define the modern analytics stack, powering digital products with deep behavioral insights. But in a world shifting toward agentic interfaces and vertically integrated AI, even a category leader has to evolve.In this episode, CEO Spenser Skates shares how he's rethinking AI within the constraints of a 13-year-old codebase, why analytics remains Amplitude's competitive edge—and why taking the company public early was a risk worth taking. Links:Connect with SpenserXLinkedInConnect with JoubinXLinkedInEmail: grit@kleinerperkins.comLearn more about Kleiner Perkins

Robert L. Smith is an Oscar and Grammy-winning, Emmy-nominated producer, composer, and engineer. His 35+ years in the music industry also includes work as a composer, director, DJ, videographer, photographer, writer, and public speaker.Based in New York City, his career spans the globe, collaborating with legends from every country. Some recent highlights include “The Get Down” for Netflix, with director Baz Luhrmann, netting a # 1 Billboard single “Telepathy” with Christina Aguilera featuring Nile Rogers and Sia; Tina Arena's # 2 album “Love saves”; Oscar and Grammy wins for the documentary “20 Feet From Stardom”; an ongoing work with Sir PaulMcCartney; production with Peter Asher for Steve Martin's latest “The Long Awaited Album” with the Steep Canyon Rangers, as well as collaborating with Alice Cooper on Pink Floyd's “Wish You Were Here” Symphonic album. Robert is currently working on his memoir, as well as helping artists navigate the ever-changing tides of the music industry.IN THIS EPISODE, YOU'LL LEARN:Studio etiquette Navigating work/life balanceWorking smarter, not harderManaging expectations in the studioFinding mentorsWorking all of the roles in a production vs. only oneGainstaging with mixing in mindHow to prepare for sessionsWorking with AerosmithThe importance of a headphone mixWorking on the TV show GleeHow winning a Grammy won't change your lifeSession organizationMixing vocals firstTo learn more about Robert L. Smith, visit: https://defyrecordings.com/Looking for 1-on-1 feedback and training to help you create pro-quality mixes?Check out my coaching program Amplitude and apply to join:https://masteryourmix.com/amplitude/ Want additional help with your music productions?For tips on how to improve your mixes, visit: https://masteryourmix.com/ Download your FREE copy of the Ultimate Mixing Blueprint: https://masteryourmix.com/blueprint/ Get your copy of my Amazon #1 bestselling books:The Recording Mindset: A Step-By-Step Guide to Creating Pro Recordings From Your Home Studio: https://therecordingmindset.com The Mixing Mindset: The Step-By-Step Formula For Creating Professional Rock Mixes From Your Home Studio: https://masteryourmix.com/mixingmindsetbook/ Check out our Sponsors:Want more Mixing or Mastering clients? Communicate your true value with MixFlip: https://mixflip.io/?affiliate=mym Download Waves Plugins here: https://waves.alzt.net/EK3G2K Subscribe to the show:Apple Podcasts: https://podcasts.apple.com/us/podcast/master-your-mix-podcast/id1240842781 Spotify: https://open.spotify.com/show/5V4xtrWSnpA5e9L67QcJej Youtube: http://www.youtube.com/@MasterYourMix Have questions you'd like...

Guest: Pedro FranceschiPedro Franceschi is the co-founder and CEO of Brex, a fintech company reshaping how businesses manage their finances.Originally from Brazil, Pedro went from teenage hacker to leading one of the most well-known names in modern financial technology—building a platform trusted by startups and enterprises alike.In this episode, Pedro shares what it took to launch “Brex 3.0,” why he moved to a single-CEO model, and how tough structural changes set the stage for leaner, faster growth.Chapters:00:00 Trailer00:46 Introduction01:45 Startup roller coaster05:21 Founders know how to have fun07:12 Belief barrier evolution12:00 Early state of life in Brazil13:23 Controlling variables15:32 Screen time19:23 Making small decisions23:27 Learning raises the bar26:15 People manager38:49 Getting underwater42:05 Growth accelerated47:51 Vision from the top down52:13 Leadership organization54:01 AI software engineering physics54:43 People complain about change59:42 Believers and non-believers1:04:09 Equity and bonus controversy1:08:40 Big swings and going public1:14:15 Control in unpredictability1:18:04 Living in a pixel1:19:52 Meditate, sleep, diet, exercise1:24:36 Mental health and stress1:33:12 Who Brex is hiring1:33:49 What "grit" means to Pedro1:34:39 OutroMentioned in this episode: Silicon Valley, Facebook, Meta Platforms, Inc., Mark Zuckerberg, Mastercard, Rio de Janeiro, iPhone, Bill Gates, Tim Urban, Jony Ive, Apple Inc., LinkedIn, Salesforce, Brian Chesky, Airbnb, Anthropic Claude, Cursor, Codeium Windsurf, Cognition Labs Devin, Vercel, Retool AI, Amplitude, Spenser Skates, Elon Musk, Tesla, Inc.Links:Connect with Pedro:XLinkedInConnect with Joubin:XLinkedInEmail: grit@kleinerperkins.comThis episode was produced by Kleiner Perkins and edited by IQvideo.The trailer and distribution for this episode were handled by Atomik Growth.Learn more about Kleiner Perkins