Podcasts about marinos

Marinos heridos del buque Cuauhtémoc podrán ser dados de alta Ahora hay Alerta Amarilla por vientos en 8 alcaldías Irán recibió propuesta de negociaciones nucleares con EU 

There were certainly many talking points from the weekend's top flight round, and we begin this episode with some positivity from Jon Steele after Yokohama FC moved out of the drop zone with an away win over Shonan on Saturday, as the sky blues continue to make a decent fist of their return to J1 (to 21:00). Then in Part 2 Jonny and Ben continue their roundup of Matchday 17, beginning with Kashima extending their advantage at the top of the table after they downed Shimizu, and Kashiwa lost at Machida. Next up is Kyoto, who piled on the misery for bottom club Yokohama F.Marinos with a fine away win, before we move on to events at Saitama Stadium, where Urawa claimed a controversy-laced home win over FC Tokyo (Ben's rant alert). Following that we review all of the other games, before finishing with a look ahead to midweek and weekend action.

* Mueren 2 marinos en choque del buque Cuauhtémoc* Reforma de fiscalías da más control al gobierno* Estados Unidos quiere poner ciudadanía en reality show

Entre 2018 y 2021, Nuevo Laredo se convirtió en el escenario de un oscuro capítulo de desapariciones forzadas en México, en el que marinos de la Secretaría de Marina fueron señalados como responsables. Casos como los de Julio César Viramontes Arredondo, Bautista Carrillo, Noé Ignacio Alférez Hernández y Jonathan Ballesteros Loza, todos jóvenes desaparecidos en circunstancias similares, provocaron indignación nacional e internacional. De los 30 marinos detenidos, solo 18 continúan en prisión, y ninguno ha colaborado con la justicia ni ha revelado el destino de las víctimas. Las investigaciones arrojaron pruebas sólidas: señales de celular que ubicaban a los desaparecidos junto al cuartel El Laguito, testimonios, fotografías y videos que apuntaban directamente a elementos de la Marina. Sin embargo, en algunos casos, los jueces descartaron testimonios cruciales, y varios marinos quedaron libres mediante amparos. Mientras tanto, el gobierno emitió una disculpa pública, afirmando que se marcaba un precedente hacia la verdad y la justicia. Pero las familias aún esperan respuestas. Este video aborda el entramado de encubrimientos, impunidad y dolor que rodea a estos casos. ¿Qué oculta realmente la Marina? ¿Quién protege a los responsables? ¿Y por qué, después de tantos años, las víctimas siguen sin aparecer? Distribuido por Genuina Media

Soccer: Yokohama F. Marinos Suffer 5 Straight Losses, Longest Streak in 17 Years

La comparsa de Marinos aprovechará además para celebrar, por fin, su 125 aniversario.

En este episodio muy especial de Songmess estamos de vuelta en Chile, hoy conversando con el cantante, compositor y productor, Francisco Victoria! Debutando en 2018 con su disco Prenda, el joven talento irrumpe en la escena chilena como parte de una nueva generación de artistas pop que incluyen a Cami y Princesa Alba, abriéndose lugar con himnos como “Marinos” y “Todo Lo Que Tengo.” En esta entrevista abarcamos sus orígenes tocando en la iglesia, su mentoría con Álex Anwandter, como desarrolla su lenguaje artístico paralelo a su oído de productor, sus múltiples nominaciones al Latin Grammy, la trayectoria que lo lleva a inmiscuirse en la industria musical de Ciudad de México, y su relación colaborativa con artistazas como Akriila y Francisca Valenzuela. Francisco Victoria - “Marinos” Francisco Victoria - “Te Puedes Ir Amor” Princesa Alba - “Como Si Fuese Real” Francisca Valenzuela - “Ardiendo” Cami - “Quiero Toda Mi Vida de Vuelta” Francisco Victoria, Akriila - “Te Quiero Tanta” Francisco Victoria Spotify: https://open.spotify.com/artist/7IoWRnQriyj7YYLpvx00jv?si=VcaFWqfzRQ2RqW2RAFYqAw Francisco Victoria YouTube: https://www.youtube.com/channel/UCkyqo81xReX8z89oagVjYGg Francisco Victoria Instagram: https://www.instagram.com/frvnciscovictoria/ Francisco Victoria Facebook: https://www.facebook.com/frvnciscovictoria Richard Villegas Instagram: www.instagram.com/rixinyc/?hl=en Songmess Instagram: www.instagram.com/songmess/?hl=es-la Songmess Facebook: www.facebook.com/songmess/?ref=settings Songmess Twitter / X: twitter.com/songmess Songmess Merch: via DM #BOPS Playlist: https://open.spotify.com/playlist/2sdavi01h3AA5531D4fhGB?si=9667cd5b49c741f5 Subscribe to Songmess on Spotify, Apple Podcasts, Stitcher, Google Play or SoundCloud, find us on Facebook, Twitter and Instagram, and contact us at songmessmusic@gmail.com.

It was another day of Saudi domination at the AFC Champions League Elite Finals in Jeddah. Michael Church reports from the Saudi city after home side Al Ahli eased their way into a semi-final match up with Al Hilal after disposing of Thai side Buriram United with relative ease. While in the second game of the day, Al Nassr made light work of J.League outfit Yokohama F.Marinos to book their place in the last four. PLUS... we hear from Al Ahli stars Ezgjan Alioski and Roberto Firmino to get their reaction after their big win as they look ahead to a match up with local rivals Al Hilal. Be sure to follow The Asian Game on all our social media channels: X: https://twitter.com/TheAsianGame IG: https://instagram.com/theasiangame Facebook: https://facebook.com/TheAsianGamePodcast 

Steve Holland não é mais o treinador do Yokohama F. Marinos. O técnico inglês é o primeiro a cair na temporada 2025 da J.League. E a pergunta que fica é: quem será o novo comandante do Marinos?No episódio de hoje, vamos falar também sobre o novo líder provisório da J1, o surpreendente Kyoto Sanga, além de trazer um resumo completo das últimas rodadas da J2, J3 e da JFL.Deixe seu recado para o Hinomaru abaixo do vídeo ou participe pelo nosso e-mail hinomarupodcast@gmail.com

Alan Gibson returned to the podcast, to help Jonny and Ben review goings-on from last midweek, and how the four Kansai clubs are faring after 11 rounds. We chat about the three J1 games - including Steve Holland's ouster at Yokohama F.Marinos after their home loss to Shimizu - and the conclusion of the 2nd round of the 1st round of the Levain Cup last Wednesday (to 18:30), before moving on to Matchday 11, beginning with our new leaders Kyoto, Kobe's fruitful week, and draws for both Osaka sides (to 1:05:55). Then in Part 2 Jonny and Ben round up the other six games, and look ahead to games coming up in Matchday 12.

Sheinbaum convoca a una Cumbre por el Bienestar Económico de ALRescatan a 17 lobos marinos en isla del Golfo de California Este viernes habrá Pícnic Nocturno en el Bosque de San Juan de AragónMás información en nuestro Podcast

Familias buscadoras piden detener  criminalización en su contraEncuentran en Ensenada lobos marinos agonizandoChina afirmó que “luchará hasta el final” y tomará contramedidas contra EUMás información en nuestro Podcast

Al igual que "Nessie" en el lago Ness de Escocia, Estados Unidos y Canadá comparten un monstruo que es visto desde hace siglos en el lago Memphremagog, que se extiende entre Vermont, Estados Unidos y Magog, Quebec. Es el "Memphre" (del que habla Gustavo en la noticia, que al parecer no es el "Champ", del lago Champlain, que sería otro más en la misma zona. Nota del Editor). También hay otro en Canadá, en el lago Okanagan: el "Ogopogo", que incluso fue filmado y es también protegido por la ley canadiense. Aclaración: Este episodio se elaboró a partir de diferentes grabaciones de Gustavo Fernández en su programa de radio AM, en LT14 Radio General Urquiza de Paraná (Entre Ríos, Argentina), en algún momento entre agosto de 1988 y junio de 1994. Hemos quitado la música original por cuestiones de derechos de autor. No contiene publicidad. Relacionados: Más texto, audio y video sobre los temas del Misterio en nuestro portal: https://alfilodelarealidad.com/ Plataforma de cursos: https://miscursosvirtuales.net * * * Programa de Afiliados * * * iVoox comparte con AFR un pequeño porcentaje si usas uno de estos enlaces: * Disfruta de la experiencia iVoox sin publicidad, con toda la potencia de volumen, sincronización de dispositivos y listas inteligentes ilimitadas: Premium anual https://www.ivoox.vip/premium?affiliate-code=68e3ae6b7ef213805d8afeeea434a491 Premium mensual https://www.ivoox.vip/premium?affiliate-code=7b7cf4c4707a5032e0c9cd0040e23919 * La mejor selección de podcasts en exclusiva con iVoox Plus Más de 50.000 episodios exclusivos y nuevos contenidos cada día. ¡Suscríbete y apoya a tus podcasters favoritos! Plus https://www.ivoox.vip/plus?affiliate-code=258b8436556f5fabae31df4e91558f48 Más sobre el mundo del Misterio en alfilodelarealidad.com

Al igual que "Nessie" en el lago Ness de Escocia, Estados Unidos y Canadá comparten un monstruo que es visto desde hace siglos en el lago Memphremagog, que se extiende entre Vermont, Estados Unidos y Magog, Quebec. Es el "Memphre" (del que habla Gustavo en la noticia, que al parecer no es el "Champ", del lago Champlain, que sería otro más en la misma zona. Nota del Editor). También hay otro en Canadá, en el lago Okanagan: el "Ogopogo", que incluso fue filmado y es también protegido por la ley canadiense. Aclaración: Este episodio se elaboró a partir de diferentes grabaciones de Gustavo Fernández en su programa de radio AM, en LT14 Radio General Urquiza de Paraná (Entre Ríos, Argentina), en algún momento entre agosto de 1988 y junio de 1994. Hemos quitado la música original por cuestiones de derechos de autor. No contiene publicidad. Relacionados: Más texto, audio y video sobre los temas del Misterio en nuestro portal: https://alfilodelarealidad.com/ Plataforma de cursos: https://miscursosvirtuales.net * * * Programa de Afiliados * * * iVoox comparte con AFR un pequeño porcentaje si usas uno de estos enlaces: * Disfruta de la experiencia iVoox sin publicidad, con toda la potencia de volumen, sincronización de dispositivos y listas inteligentes ilimitadas: Premium anual https://www.ivoox.vip/premium?affiliate-code=68e3ae6b7ef213805d8afeeea434a491 Premium mensual https://www.ivoox.vip/premium?affiliate-code=7b7cf4c4707a5032e0c9cd0040e23919 * La mejor selección de podcasts en exclusiva con iVoox Plus Más de 50.000 episodios exclusivos y nuevos contenidos cada día. ¡Suscríbete y apoya a tus podcasters favoritos! Plus https://www.ivoox.vip/plus?affiliate-code=258b8436556f5fabae31df4e91558f48 Más sobre el mundo del Misterio en alfilodelarealidad.com

Após 9 rodadas, a J1 League tem um novo líder momentâneo. No podcast desta semana, as campanhas de Machida Zelvia e Kashiwa Reysol são os grandes destaques.Na parte de baixo da tabela, os gigantes que ainda estão devendo na temporada também entram em pauta. O Yokohama F. Marinos na zona de rebaixamento é uma surpresa que ninguém esperava — e é claro que esse assunto não poderia ficar de fora do episódio de hoje.Deixe seu recado para o Hinomaru abaixo do vídeo ou participe pelo nosso e-mail hinomarupodcast@gmail.com

Renato Céspedes Michea, secretario del Colegio de Biólogos Marinos abordó en Sonar Informativo, los alcances de la discusión que ha generado manifestaciones en distintas ciudades portuarias del país.

Earlier in the week, K'Lee, Azura and Charlie caught up with Married at First Sights Australia star Jaime Marinos. She answered the burning questions from behind the scenes and also took part in clickbait. For more, follow our socials: Instagram Facebook TikTokSee omnystudio.com/listener for privacy information.

Jonny and Ben kick off this new episode with a good news/bad news ACL review (to 14:56), then they're joined by Jon Steele to chat about Yokohama FC's victory over Cerezo Osaka on Saturday, and the season so far for the Mitsuzawa outfit (to 41:02). Then we run through all of the other games from J1 Matchday 6, including Yokohama F.Marinos and Kobe notching first league wins of the season, Kashima making top flight history with their late leveler against Urawa, and Machida and Fukuoka continuing their upward trajectory, before we finish the episode with a look at the first round of the Levain Cup, and Japan's games against Bahrain and Saudi Arabia, as they look to seal qualification for the 2026 World Cup.

We had the chance to chat with Jamie Marinos from Married at First Sight! She gave us the inside scoop on whether she thinks Dave and Veronica have hooked up, shared her thoughts on the world of reality TV, and even revealed some surprising truths about the paparazzi.

A Liga dos Campeões da Ásia (ACL) chegou à sua fase de mata-mata, e já tivemos algumas surpresas. O Vissel Kobe foi surpreendido e eliminado pelo Gwangju FC, deixando os torcedores japoneses desapontados.Na ACL2, o Sanfrecce Hiroshima sofreu uma punição devido à escalação ilegal de um reforço, o que resultou em sua eliminação precoce da competição.Por outro lado, as equipes japonesas Kawasaki Frontale e Yokohama F. Marinos seguem vivas na elite da competição, buscando conquistar o título de campeões da Ásia.O Hinomaru está disponível em diversos agregadores de podcast: Spotify, Itunes podcast, Googlepodcast, Pocketcasts, Addict podcast, Radiopublic entre outros.Podcast: https://anchor.fm/hinomaru

Soccer: Yokohama F. Marinos Move to Quarterfinals of Asia Champions League Elite

A J-League chega à sua quarta rodada, e o Kashima Antlers conquista sua terceira vitória, mas não foi nada fácil. A disputa está acirrada, e a vida também não está sendo fácil para outros favoritos na luta pelo título, como o Marinos, Urawa Reds e Vissel Kobe.O Hinomaru está disponível em diversos agregadores de podcast: Spotify, Itunes podcast, Googlepodcast, Pocketcasts, Addict podcast, Radiopublic entre outros.Podcast: https://anchor.fm/hinomaru Deixe seu recado para o Hinomaru abaixo do vídeo ou participe pelo nosso e-mail hinomarupodcast@gmail.comRedes sociais:https://linktr.ee/hinomaru?s=08Recomendações:Pagina doGlauberTanakahttps://www.facebook.com/glauber.tirasPagina do jornalista Tiago Bontempohttps://globoesporte.globo.com/blogs/futebol-no-japao/Livro Samurais Azuis de Tiago Bontempohttps://leiacorner.com.br/produto/samurais-azuis/Nosso feed RSS: https://anchor.fm/s/4b16eacc/podcast/rssGrupo no Whatsapphttps://chat.whatsapp.com/HLL9THlT3Fi5NZ2ZKc3GuvSiga o canal "Hinomaru Podcast" no WhatsApp: https://whatsapp.com/channel/0029VaZPNYsCRs1gwLq92V1O#podcast #J1 #JLEAGUE2025

We round up two full rounds of top flight fixtures (with a focus on the weekend's Matchday 4) in this week's episode, towards the end of which we're joined by Neil Debnam to chat about the early days of Shigetoshi Hasebe's reign at Kawasaki. We begin with the games involving the top three - new leaders Kashiwa, who climbed to the summit with a win away at Urawa, then Shonan's draw at Yokohama F.Marinos and Hiroshima's narrow win at home over Yokohama FC - before moving on to Kashima's win over FC Tokyo, and the battle between promoted sides Okayama and Shimizu, then away wins for Machida, Gamba Osaka and Fukuoka (their first of the season), before wrapping up Part 1 with the draw between Niigata and Cerezo Osaka (to 1:03:35). Then Neil joins us to discuss Kawasaki's 1-0 home defeat at the hands of Kyoto - Sanga's first win of the year - and Frontale's prospects in the ACL Elite Round of 16 against Shanghai Shenhua, before we wrap up the episode with a look at the fixtures in J1 Matchday 5. Please check out Neil's Frontale Rabbit blog.

Jonny and Ben were pleased to welcome Stuart Woodward back to the pod, to chat about his trip to Hiroshima for Yokohama F.Marinos' visit to Sanfrecce on Sunday, a cagey affair settled by a correct, but unfortunate, penalty decision against visiting defender Jeisson Quinones that saw Hiroshima stay perfect after two rounds (to 27:20). Then in Part 2 we chat the other two sides with spotless records, Shimizu and Shonan, then move on to the four teams that won for the first time this season on Saturday, and finish with the three Matchday 2 draws.

El #220 Tripulante18 Podcast lo titulamos ‘Ante todo, marinos'. Charlamos con Juan Merediz, quién se considera él y a muchos otros antes que regatistas, marinos. Y así define también a tantos navegantes que aman la mar. Repasamos el final de la Vendée Globe cuando aún quedan varios barcos por cruzar la línea de llegada, más de un mes después de que lo hiciera el ganador. Hablamos de historias y anécdotas con las que seguiremos aprendiendo. Dirige y presenta Jaume Soler Albertí. SÍGUENOS Web: http://tripulante18.com​​ Twitter: https://twitter.com/SolerAlberti https://twitter.com/18Tripulante Instragram: https://www.instagram.com/jaume.soler/?hl=es Facebook: https://bit.ly/3eB3dDP

Nuestro particular lobo de mar Fernando G. Echegoyen, especialista en siniestros marítimos, nos hablará hoy de los monstruos marinos modernos, es decir, los avistados después del siglo XIX. Desde hace más de 200 años se hablaba de la existencia de un monstruo marino, una serpiente, en la bahía de Cadboro (Canadá). El monstruo había sido bautizado como Caddy. El 1943 el mito se vino abajo por un informe científico que afirmaba que lo que habían avistado cientos de habitantes de la zona eran leones marinos nadando juntos. Sin embargo, una filmación de 2009 destruye tal teoría. Lo que se ve en la misma es un único organismo, no un grupo de leones marinos. ¿Qué es exactamente? De momento nada se sabe. Está envuelto en el más impenetrable misterio. Echegoyen nos contará esta y otras historias sobre criaturas marinas que supuestamente habitan en nuestros mares. Escucha el episodio completo en la app de iVoox, o descubre todo el catálogo de iVoox Originals

Soccer: Yokohama F Marinos Beat Shanghai Port 2-0 in Asia Champions League Elite

El Senado de la República aprobó por unanimidad la entrada de personal militar del Ejército de Estados Unidos para capacitar a marinos mexicanos. Sí, como lo escuchan, soldados gabachos vendrán a enseñar tácticas y estrategias a nuestros elementos de la Marina.See omnystudio.com/listener for privacy information.

Now that we're up and running, our J1 season previews roll on galactically on this episode, with five more teams under the microscope. We begin with a J-Talk crossing of the streams, as Jon Steele guests to preview promoted clubs Yokohama FC (to 42:15) and Shimizu (to 1:09:00), before Jonny and Ben run the rule over Shonan (to 1:29:30) and Yokohama F.Marinos (to 1:52:35) in Part 2. Then in Part 3 we were delighted to welcome Kawasaki correspondent Neil Debnam back to the pod to preview the brave new dawn at Todoroki. You can keep track of all the goings on at Frontale on Neil's blog, and he's now on Bluesky, too.

BYD EQDISS - 1340 - Marinos y Astronáutas y, después, "El viaje del Apollo 11" (documental) Escucha el episodio completo en la app de iVoox, o descubre todo el catálogo de iVoox Originals

Esta es la historia de Steri, un pequeño delfín que no quería jugar con otros niños por temor a que se dieran cuenta de que todavía no sabía nadar bien, pero todo cambiará cuando Dona, la tortuga sabia, le presenta a Martha, una delfín que sabe volar.Bienvenidos a Había una vez, un podcast de cuentos para niños y niñas donde podrás escuchar cuentos cortos y divertidos. Nuestros cuentos infantiles están hechos para educar, entretener y divertir a los peques, si amas los cuentos para dormir, llegaste el lugar indicado. Hosted on Acast. See acast.com/privacy for more information.

Aunque los euriptéridos no son realmente escorpiones, algunos, como Terropterus, que vivió hace aproximadamente entre 440 millones de años, tenían una gran semejanza con ellos. Poseía una cola en forma de aguijón curvado, que podía proyectar hacia adelante por encima de la cabeza y el tercer par de apéndices recuerda a las pinzas de los escorpiones. Algunos podían salir a tierra firme, como demuestra un rastro fósil de seis metros de largo y 95 centímetros de ancho descubierto en 2005 en rocas del Carbonífero de Escocia. El tamaño y la anatomía de las patas que dejaron el rastro se corresponde con un ejemplar de 1,6 metros de longitud del euriptérido Hibbertopterus. Las patas, de distintos tamaños, se movían a la vez, y el animal reptaba despacio, con movimientos torpes, arrastrando la cola.

Get ready to travel back to the island of Skyros to see Marinos , as yet again, the Greek gods have a problem and need his help. Winter has taken over the island, and it won't end until Persephone, the queen of the underworld, returns back to the surface. That's going to take some persuasion! Let's see if Marinos can bring spring back to the island, and end this eternal winter!  Upgrade to Koala Kids Plus for full ad-free access to our collection of kids' shows, with bonus adventures and 8-hour episodes ⭐️ Subscribe via Apple Podcasts or visit https://koalashine.supercast.com/ Want to send in a note, joke, memo or monologue? Click here.

Nieves Concostrina habla sobre la historia del Panteón de Marinos en la Isla, en Cádiz.Ya puedes escuchar Polvo eres, exclusivo en Podimo: https://go.podimo.com/es/polvoeres

Nieves Concostrina habla sobre la historia del Panteón de Marinos en la Isla, en Cádiz.Ya puedes escuchar Polvo eres, exclusivo en Podimo: https://go.podimo.com/es/polvoeres

Nieves Concostrina habla sobre la historia del Panteón de Marinos en la Isla, en Cádiz.Ya puedes escuchar Polvo eres, exclusivo en Podimo: https://go.podimo.com/es/polvoeres

Let's head back to Greece, where Marinos Stormwrecker is having trouble with the Greek gods again... This time, it's cupid causing mischief, flying around the island firing his arrow and making people fall in love and fall out, willy nilly! It's up to Marinos to track him down and put things right. Upgrade to Koala Shine Plus for full ad-free access to our collection of kids' shows, with bonus adventures and 8-hour episodes ⭐️ Subscribe via Apple Podcasts or visit https://koalashine.supercast.com/ Want to send in a note, joke, memo or monologue? Click here.

Stiff Person Syndrome (SPS) is treatable if managed correctly from the outset. It is essential to distinguish SPS spectrum disorders from disease mimics to avoid both overdiagnoses and misdiagnoses. In this episode, Allison Weathers, MD, FAAN, speaks with Marinos C. Dalakas, MD, FAAN, author of the article “Stiff Person Syndrome and GAD Antibody–Spectrum Disorders,” in the Continuum® August 2024 Autoimmune Neurology issue. Dr. Weathers is a Continuum® Audio interviewer and associate chief medical information officer at the Cleveland Clinic in Cleveland, Ohio. Dr. Dalakas is a professor of neurology and director of the neuromuscular division at Thomas Jefferson University in Philadelphia, Pennsylvania; a professor of neurology and chief of the neuroimmunology unit and the National and Kapodistrian at the University of Athens in Athens, Greece. Additional Resources Read the article: Stiff Person Syndrome and GAD Antibody–Spectrum Disorders Subscribe to Continuum: shop.lww.com/Continuum Earn CME (available only to AAN members): continpub.com/AudioCME Continuum® Aloud (verbatim audio-book style recordings of articles available only to Continuum® subscribers): continpub.com/Aloud More about the American Academy of Neurology: aan.com Social Media @ContinuumAAN facebook.com/continuumcme Full episode transcript available here Dr Jones: This is Dr Lyell Jones, Editor-in-Chief of Continuum, the premier topic-based neurology clinical review and CME journal from the American Academy of Neurology.  Thank you for joining us on Continuum Audio, which features conversations with Continuum's guest editors and authors who are the leading experts in their fields. Subscribers to the Continuum journal can read the full article or listen to verbatim recordings of the article and have access to exclusive interviews not featured on the podcast. Please visit the link in the episode notes for more information on the article, subscribing to the journal, and how to get CME.   Dr Weathers: This is Dr Allison Weathers. Today, I'm interviewing Dr Marinos Dalakas about his article on stiff-person syndrome and GAD antibody-spectrum disorders, which is part of the August 2024 Continuum issue on autoimmune neurology. Dr Dalakas is a world- renowned expert in neuromuscular diseases and, really, the first name any neurologist thinks of when they hear the diagnosis of stiff-person syndrome. Dr Dalakas, this is such an honor to be able to speak to you today. Welcome to the podcast, and would you please introduce yourself to our audience?   Dr Dalakas: Yes, thank you very much. I'm so happy to participate in this interview. I'm the Chief of the Neuromuscular Division at Thomas Jefferson University in Philadelphia, and I am interested in autoimmune neuromuscular diseases for many years and also on disease mechanisms and immunotherapy.   Dr Weathers: Thank you again for talking with me today. So, given how very rare stiff-person syndrome and the GAD antibody-spectrum disorders are, prior to December 2022, I would have started our time together by asking you to explain this collection of diagnoses to our listeners and by also talking about how often they occur. It feels like that's a bit unnecessary ever since Celine Dion went public with her diagnosis - that moment really changed the public awareness of what was previously outside of neurology and almost unheard-of disease. So, instead, I'll start with, what is the key message of your article? If our listeners are going to walk away remembering one thing from our discussion, what would you like it to be?   Dr Dalakas: Well, I think the publicity has been very good for the disease, this disease spectrum. On the other hand, there have been some misleading messages, like, it's extremely rare, it's untreatable, it's disabling – which, they are partially correct, so, my message is, first, to make sure the neurologists make the correct diagnosis, because there are a lot of diseases similar to stiff-person, but they are not stiff-person. So, to make sure the diagnosis is correct and to make the patients aware of what to expect when they have this disease and what therapies we have and what we may have in the future. So, the number one message is the correct diagnosis and then to avoid overdiagnosis or misdiagnosis, because now we see both - we see overdiagnosis and misdiagnosis.   Dr Weathers: I think that's such a critically important point, and one you really delve into really beautifully in the article, so I encourage our listeners who do have access to it to really read through it. As I said, you do a great job really explaining that - and, actually, to go into that further, could you explain how you approach the diagnosis of a patient with possible stiff-person syndrome or one of the other GAD antibody-spectrum disorders? And I know you probably get asked that on a daily basis. As I was telling you before we actually formally started recording, I remember back when I was a resident and saw my first case of a suspected patient with stiff-person syndrome, my mentor advised me to look up your case series, your articles at the time, and really use that to guide my diagnosis. What do you feel is the most challenging aspect of diagnosing a patient with one of these conditions?   Dr Dalakas: Well, the first is the clinical symptomatology. We say the patients present with spasms and stiffness, but also, there are phobias. They are very hyperexcitable to sudden stimulations, to sudden noises, to unexpected touches, and all of them can cause spasms, and then when you examine the patients, they have stiffness. Now, the stiffness (if there is a true stiffness) results in gait abnormalities (the patients are falling because they're so stiff), and also, the hyperexcitability causes a lot of anxiety and a lot of phobias (they're afraid to cross the street, they're afraid to make a destination promptly) – so, all these things are sort of suggestive of stiff-person. So, these are the symptoms that you hear, you listen, and you ask the patients, and then, when you examine the patient, you look for certain signs that there are, specifically, like stiffness of what we call agonist muscles and antagonist muscles, which means there is stiffness of the abdominal muscles and at the same time, stiffness of the back muscles - so, this concurrent stiffness of these opposing muscles is very specific, very characteristic of the stiff person, so if you see that, and then you listen to the history, you're very close to the diagnosis, and then you do the antibodies. And the antibodies (the specific antibodies, the GAD antibody), but it is specific as we say in the article, and we tried to make this very clear to the neurologists, that it's the high titers that matter, because low titers are not necessarily specific. So high titers of antibodies in the serum, above 10,000 by ELISA (or whatever method they use; but it has to be this many times above normal), and then if you have high serum titers and all the symptoms they mentioned, it is stiff-person. On the other hand, if the titers are low, then you may want to do a spinal tap to see if there is synthesis of antibodies in the spinal fluid. That helps you. Now if the GAD antibodies are negative, then you start wondering, is this seronegative SPS? And how do you confirm the seronegative SPS? You do electrophysiology, and the electrophysiology is, again, to see if there is activity (muscle activity) concurrently from the agonist and antagonist muscles - in other words, from the, let's say the tibialis anterior and the gastrocnemius (so, it's two opposing muscles, eg, biceps and triceps) - and if you see activity in both of these opposing muscle groups, and you see also hyperexcitability (you touch the patient, you stimulate just a little, and you see activity in other muscle groups). So, the electrophysiology is very important if the patient's antibody negative, but they have the other symptoms that I mentioned before.   Dr Weathers: I can imagine how challenging those must be (those seronegative cases) to try to really make sure you're identifying and carefully determining that you have the right disease as you alluded to at the beginning. I know how hard it must be for patients to want to at least have some answers to have a diagnosis.   Dr Dalakas: And this is the main thing today, because the publicity, as I mentioned, the beginning, increased the receipt of some information, so they overdiagnose it, like, “Oh, you have this and this and this, so it may be stiff-person”. And so, in fact, recently, we had a series of patients together with the Mayo Clinic Group of out of 173 patients referred to the Mayo Clinic for stiff-person – that's referred to them - only 28% had stiff-person. It's a low percentage, but it is an indication that the neurologists now refer patients to us for stiff-person, but we need to be very careful to correctly make a diagnosis.   Dr Weathers: On one hand, it's good that people are aware and considering the diagnosis, but it does highlight that risk of overdiagnosing.   Dr Dalakas: Yeah. It's the opposite of when I started this stiff-person syndrome (was close to 30 years ago at NIH) - at that time was underdiagnosed. This was the most rare disease, and I collected patients because at the NIH, I was also the Chief of the neuromuscular division there, and I was doing a study, so it was easy to collect patients (I collected more than 100 patients), but at that time, it was misdiagnosed. So, we had patients that I was seeing and they're really disabled, because they have been having the disease for many years, but they had been diagnosed either for Parkinson disease, for anxiety disorder, for psychiatric diseases, or for MS, or for myelopathies, or for myelitis - so many different things, and of course, they didn't have the correct diagnosis and they were disabled.   Dr Weathers: The side effect of having one of the most famous celebrities in the world having this rare disease - you know, the downside of the increased awareness, as we've said. So, moving on from the diagnosis to treatment - again, you do a, obviously, you know, an incredible job in the article, really going through the treatment options and your algorithms - what would you say is the most common misconception you've encountered in treating patients with this disease?   Dr Dalakas: The most common is now (with the publicity) is that it is a disabling disease. Well, it is disabling, but if you treat the disease correctly and early on, I'm not saying we're curing the disease - many diseases (autoimmune diseases), we help a lot, so there are some we make the patient feel normal, but the disease is there - so, if we start the correct therapy early, a good number of patients respond very well. But by the time the patients come to us, they are so stiff, they walk like a statue, or they come in a wheelchair - of course, it's difficult to reverse this, although we have been very happy to see patients with immunotherapies to get out of the wheelchair, to walk, to enjoy normal activities. So, we have made enough progress with the therapists to help a good number of patients. Now, what is the first therapy we do? Well, is what we call the antispasmodics - these are drugs that relax the stiffness that patients have, sort of a symptomatic therapy. It's not going to address the disease itself, but we address the symptoms. And of course, the symptomatic therapy in SPS is not just to relax the patients - it is related to the so-called GABAergic inhibition. So, the drugs that we use (like the benzodiazepines, or the baclofen, et cetera), these are the drugs that work on the GABAergic pathways. So, it is symptomatic therapy, but it works also on the mechanism, so it's not just a relaxing basis - but since the patients have a lot of phobias, the benzodiazepines also help the phobias. The anxiety and the phobias make the patients worse - they make them more stiff. And in the beginning, they go to psychiatrists because they are so phobic - they're phobic to walk. They hear something, they get so stiff. And I have patients coming at the National Airport in Washington to come to there needing aids in getting out of the plane - some of them get so stiff, they have to get an ambulance to come to the hospital because they're stiff everywhere. So, these phobias and anxiety have triggered a lot of my interest to the point of asking the investigators at the National Institute of Mental Health to see if there is any such thing like autoimmune phobias, because these patients have an autoimmune disease, so, well, maybe we can treat the phobias of immunology - well, we did not find anything, but I just sort of brought the idea maybe we have an autoimmune phobia. But on the other hand, when the patients get better, the phobias are reduced and they're more comfortable to walk. So, it's a very interesting complexity of the symptoms altogether.   Dr Weathers: That is – and, actually, that leads into my next question somewhat, that, as I mentioned in your introduction, you are the world expert in this rare disease. How did that happen? You talked about it a little bit just now. But how did you develop this particular interest and expertise? What drew you to this particular disease?   Dr Dalakas: Yes. It's interesting. I was interested in autoimmune neuromuscular diseases (many of them) and neuropathies and myopathies, and one day, I had a good friend of mine who was the clinical director of NINDS at that time, Dr Hallett. So, he saw patients in the movement disorder clinic and they had stiff-person (I don't know why they went to the movement disorder, but they went there), and Dr Hallett said, “Well, this is an autoimmune disease. You should work on this.” And then, I started seeing one or two patients, and I was very impressed. Really, the symptomatology is so interesting. The patients are suffering, and they sort of give the impression that they're neurotic. So, it's just a combination of when you listen to the symptoms, I was very impressed with the depth of the discomfort that they have and without seeing anything - but, when you examine the patient, you see the stiffness and nothing else. They're not weak, like, we see patients with MS, with myopathies, with neuropathies - they have weakness. They may use a cane, they may use two canes, they may use a walker, because they're stiff. So, it's a different disability than you see in patients who are weak. So, this really made me so interested to understand the mechanism - what's going on here - and that's the reason I started and I put the protocol. And then, we did a lot of immunological studies to understand the mechanism, electrophysiological studies to look at these agonist and antagonist muscles - and of course, we named it also. You know, in the beginning, the syndrome was described as stiff man (stiff-man syndrome), and they're all women. They are most of them, women. In fact, there is an article in a major journal, three women with stiff-man syndrome - and this was many years ago. So, stiff-person will be a more proper term. And then we're seeing a lot of patients or more women, but also we have enough men.   Dr Weathers: So, we've talked a lot about the change with this disease in public awareness. How has that changed your day-to-day life - has it (with the change in public awareness)? Are you bombarded with media requests?   Dr Dalakas: Well, it has stimulated me to write more about the disease and more articles, but also to highlight certain things that were not known before. For example, I had recently a paper on late-onset stiff-person. So, people, we see now patients who develop stiff-person at the age of seventy - they are above sixty or so, overall - and they have more severe disease. These patients also have not good tolerance to the medications we use - so, it's a more challenging group, so it is important to make the diagnosis even in patients with late-onset. These people do less well, because, first of all, they're all misdiagnosed, because if you're a little stiff at the age of sixty-five or seventy - well, you have a bad back, so you all have degenerative disc disease, so you don't think of stiff- person in that age. So, the stimulus was to identify some other issues with the stiff-person. The other is to think of new trials - and I have been working on two new trials. They're not out yet. I'm working to see how best to apply the new therapies. And also, it came up the idea of what are the best ways to assess, objectively, to assess the response, because this is an issue from the beginning. When I did controlled trials at the NIH, and we had established the so-called stiffness index to see how stiff they are measurably, but it is still subjective. It's not really objective, it's not (weakness to measure). So, we have gait analysis, we have the time to walk. So, I think establishing objective criterion to assess response to therapy, it's an important one - and so, I have been working on this how to make it more objective or as subjective as we can.   Dr Weathers: I think that's fantastic. And you actually, I think, have already answered my question - which is, what is the next breakthrough coming in the diagnosis and management of patients with stiff-person syndrome and the GAD antibody-spectrum disorders - and I think it's going to be the outcomes of these trials. Is there anything else that you're really excited about coming along in this field?   Dr Dalakas: Well, I think that the hope is, then, better immunotherapy, because the patients respond to IVIG based on the controlled study. We did one with anti-B-cell therapy - it was not statistically positive, but we had some placebo effects, because that second trial included some patients who did not have severe disease, so it was difficult to assess mild response. So, I'm interested in other similar immunotherapies, and we were approaching companies to see if they can sponsor such a trial. I think the publicity helps a lot, because if I was going to approach a company before the publicity, nobody would be interested in - there's no, you know - it's money-driven, so they will not do it. But at the NIH, I did it, because NIH had the grants there to sponsor the trials. So, I think the publicity will help us. And I know talking to companies, there are one or two companies that they have expressed a lot of interest, and, hopefully, we can do some new trials and go work on it, but I don't have any clear drug at the moment. I cannot discuss a real drug.   Dr Weathers: Of course, of course, more to come, but still very exciting. And so, still to learn more about you - again, you're so well known, obviously, for what you've done for the field of neurology. What do you like to do outside of seeing neuromuscular patients in your research career? What do you do for fun for your hobbies?   Dr Dalakas: Well, I have two hobbies. One is I'm an art collector of abstract expressionism. So, I go to a lot of auction houses, and I bid often for certain artists that I'm very interested, some French artists, some at the New York School of Modern Art. The eras of the forties and fifties of the abstract expressionism - so that's my collection and my interest in not missing auctions. And the other was I have a interest in wine collection – but, so, most of the time, I read art and I collect art.   Dr Weathers: That is a great answer. I appreciate art. I am not (fortunately) at the auction and collecting stage yet, but that I will have to learn from you. That's wonderful.   Dr Dalakas: Yeah. I'm originally from Greece, and I have also a professorship at the University of Athens, and also I go there. I also have some European artists in my collection.   Dr Weathers: That's wonderful. We have one more modern piece that we've been lucky enough to have.   Dr Dalakas: Yeah, I started with the impression impressionistic art, but I evolved into abstract.   Dr Weathers: Who is your favorite artist?   Dr Dalakas: Well, it's, you know, Rothko and Newman. So, these are very expensive artists, of course, so I can, but in that school, so these artists are not alive now, but people who are working with Rothko and Newman in the other group - so, there are four or five of them that I collect.   Dr Weathers: I feel like we need a whole separate interview just to talk about that.   Dr Dalakas: But, they are very stimulating, because the colors talk to you, and it's not like an impressionistic piece that, sort of, their flowers are nice, et cetera - so the colors talk to you differently.   Dr Weathers: They do. I love Rothko. Well, thank you, Dr Dalakas, for joining me on Continuum Audio. This has been a wonderful conversation. Again, today, I've been interviewing Dr Marinos Dalakas, whose article on stiff-person syndrome and GAD antibody-spectrum disorders appears in the most recent issue of Continuum on autoimmune neurology. Be sure to check out Continuum Audio episodes from this and other issues, and thank you to our listeners for joining us today.   Dr Monteith: This is Dr Teshamae Monteith, Associate Editor of Continuum Audio. If you've enjoyed this episode, you'll love the journal, which is full of in-depth and clinically relevant information important for neurology practitioners. Use this link in the episode notes to learn more and subscribe. AAN members, you can get CME for listening to this interview by completing the evaluation at Continpub.com/AudioCME. Thank you for listening to Continuum Audio.

Nieves Concostrina habla sobre la exhumación de los restos del almirante Salvador Moreno Fernández, quien comandase uno de los tres cruceros que masacraron a miles de civiles andaluces durante la Desbandada, del Panteón de Marinos Ilustres de La Isla, en Cádiz.Ya puedes escuchar Polvo eres, exclusivo en Podimo: https://go.podimo.com/es/polvoeres

Nieves Concostrina habla sobre la exhumación de los restos del almirante Salvador Moreno Fernández, quien comandase uno de los tres cruceros que masacraron a miles de civiles andaluces durante la Desbandada, del Panteón de Marinos Ilustres de La Isla, en Cádiz.Ya puedes escuchar Polvo eres, exclusivo en Podimo: https://go.podimo.com/es/polvoeres

Nieves Concostrina habla sobre la exhumación de los restos del almirante Salvador Moreno Fernández, quien comandase uno de los tres cruceros que masacraron a miles de civiles andaluces durante la Desbandada, del Panteón de Marinos Ilustres de La Isla, en Cádiz.Ya puedes escuchar Polvo eres, exclusivo en Podimo: https://go.podimo.com/es/polvoeres

En libros preguntamos a nuestros oyentes cuales han sido sus lecturas de verano. Nieves Concostrina nos explica eso de Panteón de Marinos (asesinos) Ilustres. Terminamos con ?lo que queda del día'

Tercer Milenio 360 Internacional - 23/08/24 Surge un nuevo peligro mortal en el agua del planeta, y es que los tornados marinos se están volviendo cada vez más frecuentes y peligrosos debido al cambio climático. Los cóndores retoman su vuelo en México. Descubren una nueva evidencia del pasado de Marte, el cual, pudo haber sido habitable. En el Reino Unido, una familia capta a un objeto volador de color rojo y con forma de disco. En Washington D.C. captan dos objetos que emitían señales de luz como si intentaran comunicarse.

Comenzamos el circuito alrededor de la esquina noreste del Círculo Medicinal. En el totem # 13 hallamos la intuición y el sentido común del Ganso Blanco de Nieve. En el totem # 14, nos encontramos con la naturaleza juguetona y el deleite del existir en comunidad del León Marino. En el totem # 15, descubrimos el Puma, representante de los Grandes Felinos, honrados por comunidades por todo el mundo, y aprendemos acerca de una ceremonia de restauración de la unidad compartida para honrar el Oro, la fuerza vital del Sol, un ritual diseñado y conservado por los Koguis, de la Sierra Nevada en Santa Marta, Colombia.  

In this episode of the K League United Podcast, we hear from Ulsan HD midfielder Darijan Bojanić who talks about his move to Ulsan, life in South Korea, working with Henrik Larsson and Graham Potter, the best player he's played with, that ACL semifinal against Yokohama F. Marinos, his international career, and much, much more.

Dan Orlowitz returned to the pod to give his thoughts on the top four, Harry Kewell's exit from Yokohama F.Marinos, FC Tokyo's progress under Peter Cklamovski, and the bumper crowds at, and management of, The National Stadium in Part 1 of our new episode (to 1:10:10), before Jonny and Ben roundup the Emperor's Cup results from last midweek, wrap-up the remainder of the J1 Matchday 23 results, and look ahead to the weekend's final round before a two and a half week break.

We begin this episode by rounding up a dirty week for Yokohama F.Marinos, who lost twice in four days, Gamba Osaka putting them to the sword on Saturday night to ramp up the pressure on Harry Kewell (to 21:00), before we round up victories for the other top four sides (to 35:50). Then in Part 2 Lewis White returns to the pod to chat about Tokyo Verdy's 1-1 draw with Cerezo Osaka and their tremendous first season back in the top flight (to 59:10), before we review a good weekend for most of the relegation dogfighters (to 1:31:25), chat about Japan's Olympic squad named late last week, and preview Wednesday night's third round of the Emperor's Cup, and the weekend's J1 Matchday 23.

Conocemos mucho del universo, de nuestro entorno, de muchas otras cosas, pero del mar seguimos teníendo un gran vacío de conocimiento, ¿qué habita las profundidades, acaso hay monstruos?Conviértete en un seguidor de este podcast: https://www.spreaker.com/podcast/relatos-del-lado-oscuro--5421502/support.

Sean Carroll returns to the pod as we review the past two top flight matchdays (with a focus on the weekend's Matchday 21), and then piece together the Team of the (Half) Season. In Part 1 we review Machida's massive win at Gamba Osaka and Kobe seeing off Kashima in the other battle between top four teams (to 24:00), then chat about the good recent runs Cerezo Osaka and Fukuoka are enjoying (to 35:15), before discussing Hiroshima, and where they might improve after a couple more frustrating draws (to 41:30). Then in Part 2 its Team of the (Half) Season time (to 1:28:00), before we run through the other five games from the weekend, the changes in personnel at Urawa, what's going wrong at F.Marinos, and the Relegation Dogfight.