Podcasts about hs1

Today is a special interview with Mark Smith – the train travel expert also known as ‘The Man in Seat 61'.  We discuss his background; how he came to set up his website seat61.com; his views on the best routes to the Alps by train; the trend towards night trains; plus whether there will ever be competition for Eurostar on the cross-channel line.  Intersport Ski Hire Discount Code If you're heading to the Alps this winter, then you can save money on your ski hire by using the code ‘SKIPODCAST' at intersportrent.com, or simply take this link for your discount to be automatically applied at the checkout.  SHOW NOTES Seat61.com is a multiple award-winning website with more than 1m visitors per month (2:00) Why is it called ‘Seat 61'? (2:30) What prompted you to start the site in 2001? (4:15) Mark has worked full time on Seat61.com since 2007 (7:00) Iain took the ‘Flight Free Pledge' to take no flights in 2024 (8:45) Why should people travel by train? (9:00) Come for the carbon savings, stay for the joy of travelling by train (9:15) “We're in danger of creating a world where every single journey is an identical non-experience at 30,000 feet and life's too short not to grab every experience when you get the chance.” (11:30) Listen to Iain's report on the Eurostar Snow Train (13:00) Will Eurostar ever bring back that direct service? (13:30) Or that they might increase the number of rotations? (15:45) Will we see competition to Eurostar on the cross-channel HS1 line? (18:00) Virgin are interested in starting as a competitor to Eurostar (18:30) When will the line from Paris to Turin open again? (21:00) Taking the train to Italian ski resorts (23:00) Taking the train to Austria (24:00) Taking the train to Norway (25:00) The Caledonian Sleeper is ‘Best train in the UK' according to Mark (26:00) Simon Calder and Mark raced to Edinburgh in a plane v. train race (27:30) Night trains are becoming more popular (28:30) OBB's ‘Nightjet' service is the biggest operator of night trains in Europe (29:30) The Nightjet to Innsbruck departs from Amsterdam (31:00) Listen to Iain's interview with Chris Engelsman, co-founder of European Sleeper (31:30) Mark will be on the inaugural European Sleeper service (32:30) Boutique operators include Snälltåget and European Sleeper (33:30) How do you keep the costs of train travel down? (35:00) When is Interrail better value than point-to-point tickets? (37:00) Why do you have to wait to three months beforehand until you can book trains? (38:30) Iain will be travelling to Sicily on the only train ferry left in Europe (40:45) Is it possible to travel from Portugal to Singapore by train? (42:00) Take the plunge, you'll love it! (44:00) “Collectively we are racing through spectacular landscapes, covering a mile every 40 seconds, using Victorian infrastructure to the full and causing minimal environment harm. The rail traveller is in touch with the world.” Feedback I enjoy all feedback about the show, I'm always interested to hear what you think, so please do contact me on social @theskipodcast or by email theskipodcast@gmail.com    Dan Trapp: "Keep up the great work. And have a great season!"  Alex Nevill (BMAC): "Love this podcast, always gets me in the mood for the ski season" There are now 245 episodes of The Ski Podcast to catch up with and a whopping 202 of those were listened to in the last week. There is so much to listen to in our back catalog, just go to theskipodcast.com and have a look around - you're bound to find something that sparks your interest.  If you like the podcast, there are three things you can do to help:    1) Follow us. Just take a look for that button and press it now  2) Give us a review or just leave a comment on Apple Podcasts or Spotify  3) Book your ski hire with Intersport Rent using the code ‘SKIPODCAST' or take this link You can follow Iain @skipedia and the podcast @theskipodcast

Okay, so I've been teasing this for a while now, and at last it is here... We are going to spend this week's episode talking about what a FINISHED high speed rail network for the UK and Ireland would look like. Not shared lines, but dedicated high speed lines built from new. How does HS2 fit in? How might it link with HS1? What about Greengauge 21s "X" network? Scotland? You better believe that there will be much in the way of maps and CAD! All comments welcome... This won't be the last of these episodes, I would guess. Enjoyed this? Please do consider supporting #Railnatter at https://patreon.com/garethdennis or throw loose change at me via https://paypal.me/garethdennis. Merch at https://garethdennis.co.uk/merch. Join in the discussion at https://garethdennis.co.uk/discord.

In this episode of Becker's Healthcare podcast, join host Brian Zimmerman as he engages in a compelling conversation with Donnie McMaster, Director of Operations for NC and SC, and Ephy Weinberg, Director of Operations for MI, both from Guardian Dentistry Partners. Together, they explore the intriguing journey of Guardian Dental in implementing Jarvis Analytics, delving into the initial goals, integration into operational strategies, and the significant impact on decision-making processes. Donnie and Ephy share insights into how Jarvis Analytics has streamlined processes, enhanced efficiency, and improved key performance indicators across multiple dental practices. The episode concludes with a forward-looking perspective on future initiatives, optimizations, and invaluable advice for dental practices and DSOs considering the integration of Jarvis Analytics. Special thanks to our sponsor, Henry Schein One. Tune in for this enlightening discussion and discover how Guardian Dental is revolutionizing dental management with innovative analytics.This episode is sponsored by HS1.

Plusieurs fois par an, je lance la Wellness impact academy : le parcours création .  Aujourd'hui je t'enmène dans les coulisses de L'academy. Comment faire évoluer son entreprise et ses offres dans un marché du bien-être en constante évolution ? C'est ce qu'il m'est arrivé pour la Wellness impact academy : le parcours création.  Je vous dévoile : mes réflexions et conclusions, les difficultés que j'ai pu rencontrer, les erreurs que j'ai commises, l'importance de répondre aux véritables besoins de nos clients, les remises en questions, mais aussi les leçons que j'ai pu en tirer ! Pas facile, facile tout ça  

Ana, Lizzie and Hallie continue their (postponed many times) discussion on Harry Styles' discography of his self-titled debut album (aka HS1), Fine Line, and finally, Harry's House. They break down some lyrics, melody, and overall feel of each album. --- Send in a voice message: https://podcasters.spotify.com/pod/show/boybandpod/message

Le Dr Jean-Philippe Rigaud, qui est chef du service de Réanimation à l'hôpital de Dieppe, nous parle aujourd'hui de la consultation post-réanimation en 2022. Aucun conflit d'intérêt n'est déclaré. Sommaire Que représente la consultation post-réanimation ? Quel en est l'intérêt pour les patients, leurs familles et les médecins réanimateurs ? Comment peut se mettre en place une activité de consultation post-réanimation ? Références Rigaud JP, Gélinotte S, Beuzelin M, Marchalot A, Eraldi JP, Bougerol F, Ecarnot F, Quenot JP, Declercq PL (2022) Consultation post-réanimation : un outil désormais indispensable en 2022. Méd Intensive Réa 2002 31(HS1) 79-86 Jensen JF, Thomsen T, Overgaard D, et al (2015) Impact of follow-up consultations for ICU survivors on post-ICU syndrome: a systematic review and meta-analysis. Intensive Care Med 41:763-75. DOI : 10.1007/s00134-015-3689-1 Davidson JE, Aslakson RA, Long AC, et al (2017) Guidelines for Family-Centered Care in the Neonatal, Pediatric and Adult ICU. Crit Care Med 45(1): 103-128DOI : 10.1097/CCM.0000000000002169

HS1 ellterskelitor

Episode 64 of Live On Set marks the podcast debut of Austin's friend, Sara Santiago. This episode is part one of the two part Austin & Sara all things Harry Styles residency. Topics include: Sara's history with the One Direction & Harry's solo work, favorite songs from HS1 & Fine Line, and tease Harry's latest release, Harry's House.

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David Fischer startete vor 17 Jahren einen kleinen Blog namens Highsnobiety und heute ist daraus eines der größten meinungsbildenden Online-Magazine im Bereich Streetwear geworden mit fast 200 Mitarbeitern. Ich nenn es jetzt einfach mal Magazin, auch wenn Highsnobiety sehr viele unterschiedliche Kanäle bedient. Also Hype-Culture und Ohne den Hype – man könnte ja meinen, das passt nicht wirklich zusammen, aber wir sprachen eben ohne viel Hype über den Hype. Okay, sorry dafür, aber es war sehr spannend von Mr. Snob persönlich alles über seine Anfänge zu erfahren, darüber wie er teilweise bis zu 40 Posts am Tag ganz alleine produziert hat, über die Meilensteine seiner Firma und über sein Privatleben.

My guest today is Wendy Spinks, Wendy is the Commercial Director for High Speed 1, who own and operate the UK's first section of high-speed rail, as well as the stations along the route: including St Pancras International, that connects London to Paris, Brussels and Amsterdam In the podcast, we discuss how the volume around compassion in the workplace is being turned up, how the Me-Too campaign was a catalyst for this shift and how Wendy uses gardening to help her work life balance.We talk about how the pandemic has impacted HS1, the difficult conversations held with stakeholders, and Wendy's views on the future challenges for hybrid working. Wendy believes transparency is increasing in business and we discuss why that's a good thing and how having more balanced boards in the future will give businesses a different dynamic.As my previous landlord Wendy was a great supporter of Prime Burger an independent business that I owned and operated at St Pancras for many years, it was a pleasure to meet up again and have a conversation about compassion in business. Enjoy the show. Hosted on Acast. See acast.com/privacy for more information.

In this episode Catherine Burrin, Rail Apprentice at Thales and Sam Sage, General Graduate Management Trainee at HS1 talk about their introductions into the Rail Industry

In episode 14, hosts Key (he/they) and Gray (he/him) cover the various Harry Styles-related news stories from the past month, as well as breaking down their top 5 photos Hélène Pambrun has taken of Harry (inspired by her recent interview on the podcast “Straight Up”) They begin by diving into Harry's surprise appearance at the Brit Awards (6:55), which of course wouldn't be complete without some HS3-related clowning. After briefly touching on the 4 year anniversary of HS1, they then get into the deluge of My Policeman set photos that have dropped since the last episode (19:54). Tiny shorts, Harry freezing on the beach, his tattoos peaking out- it's all here! Finally, after some rampant speculation about the Don't Worry Darling trailer (28:07), they discuss Harry's frequent collaborator photographer Hélène Pambrun's interview on the podcast “Straight Up” (33:08). This leads them into a breakdown of their top 5 photos she has taken of Harry. If your fave photos weren't included, you can shame Key and Gray @harrystylespod! They close out the show by chatting about some non-Harry things that have brought them joy over the week (55:02). Email us at weblameharrystyles@gmail.com Follow us on twitter @harrystylespod Follow us on tumblr harrystylespod.tumblr.com Sources: The photos discussed: https://docs.google.com/document/d/1BFys3h6ZmDJyHKvnPPxIuIxy6DA8HLoC7qwnoAMx8IY/edit Hélène's interview transcript: https://carl-and-pearl.tumblr.com/post/652297985457340416/h%C3%A9l%C3%A8ne-pambrun-for-straight-up-full-interview

My guest Dyan Crowther has run a traditional rail franchise, a non-revenue risk rail franchise, a region of Network Rail and now leads Britain's only High Speed line at HS1.With experience of such a mix of incentives, systems and structures, she is the ideal person to talk to about running a railway in the post-Williams era.

Grammy and Brit award winning Harry Styles is always giving fans and even haters something to talk about. Here at THWK we choose love and kindness, and we believe that is what got Harry through the turbulence written about in underrated Track 1 of 'Harry Styles', "Meet Me in the Hallway". This album intro goes beneath any barriers to reveal the true grit of what it means to be left by the one you love, with no resolution in sight. Join us as we dive into the depths of this masterpiece, poetry, artwork and so much more!

In this episode, Dale and Val lift the hood on the UK mega program Crossrail with Richard Palczynski and talk about what systems work on mega programs with our good friend Nat Moyes. Crossrail is a railway construction project underway mainly in central London. Its aim is to provide a high-frequency suburban passenger service crossing London from west to east, to be branded the Elizabeth line, by connecting two major railway lines terminating in London, the Great Western Main Line and the Great Eastern Main Line. The project was approved in 2007, and construction began in 2009 on the central section and connections to existing lines that will become part of the route. About our guests..  Richard joined Arcadis in February 2019. Throughout his career, he has collected both hands-on programme management experience after working on major programmes such as the Jubilee Line Extension, HS1, West Coast Mainline and Crossrail, where he was Programme Controls Director. In his latest role, he is supporting Network Rail’s Transpennine Route Upgrade Programme – a £multi-billion enhancements scheme stretching from Manchester to York. Richard has also collected 6 years in the corporate world helping to run, grow and evolve companies such as Parsons Brinckerhoff, Balfour Beatty and Mace. He is a Fellow with the Institution of Civil Engineers and the APM and is a Supervising Civil Engineer, passionate about skiing and triathlon. and... Nat Moyes has 12 years at the same software company which is starting to become a rarity, but that is Natalie’s Tenure at Deltek supporting their PPM products and clients. She's seen a lot of industry change, and she's had the privilege to support a number of established clients as well as grow some new ones. She's been involved in the APM SIG, steering committees, user groups and general advisory boards, all focused on people, process, toolset. Don't forget to buy some Project Chatter merch in our Charity Shop, where all profits are donated to our charity partners. This podcast sponsored by: JustDo.com InEight.com PlanAcademy.com get $75 off any course by heading to https://www.planacademy.com/chatter --- Send in a voice message: https://anchor.fm/project-chatter-podcast/message

Today's special guest is standup comic and fellow podcaster Handren Seavey @handrenseavey We talk Handrens 10 years in comedy, when he lived in a tricked out school bus, biking, Mark Wahlberg and more. Show Notes: Check out Handren's Two Podcast: “Two Live and Bike in LA” , And “I Don't want to wait” (about Dawson's Creek with Kim Mcvicar) and his comedy special HS1 on Spotify. Host IGs @linsmayer @ryanthecableviewer @nickwithnothingbettertodo

TBSL is not holding back! HS1 or Fine Line? Who is TBSL about? This week we ask and answer those burning questions that surround Grammy Award Winner 'Harry Styles' complex music. Along with poetry reveals, Google Auto-Fill and much more!Celebrate our family of 10k listeners, 100 Countries and being in the Apple Top 100 Arts Podcasts! Huge thanks to Podcorn for sponsoring this episode. Explore sponsorship opportunities and start monetizing your podcast by signing up here: https://podcorn.com/podcasters/All the love,K 

Oh to be Townes... Or not? This week is all about the big break that IS the entertainment industry and how one of the biggest fandoms in the world has made it their brand to write themselves into it! Don't miss a second of Q+A breakdowns, Etsy exclusives and the most chaotic MIMS to date!All the Love,K 

In this Episode of High Speed Tales apprentices Amelia and Hannah speak to the CEO of HS1, Dyan Crowther. They talk to Dyan about the lessons learnt from HS1 and how they can support HS2, why there are still too few women in the consturction industry aswell as a look back on Dyans' career and the hard work she put in to gain her success.

This is my debut comedy album HS1. It will be out as it's own podcast on 12/17 but you my loyal listeners get an exclusive preview. Most comics sell their albums I am giving mine away for free because I want as many people to hear it as possible. But, if you'd like to donate because you love it so much then send me some loot PayPal CashApp $HandrenSeavey Enjoy and tell your friends!

Yeah maybe we ARE a little late publishing this week, and what about it? We've got our Harry Styles debut album rankings cooked up and ready to go tho. This episode we're discussing Liz being cyberbullied, SNL, how Townes cannot be a real person, spontaneous Jewish terminology, and Em's tragic ex-boyfriend's terrible HS1 opinions. Let's go :))) https://twitter.com/coatdpod https://www.instagram.com/coatdpod/ https://www.facebook.com/COATDpod https://www.tiktok.com/@coatdpod? COATDmail@gmail.com Music: Crimson Fly - Huma-Huma https://youtu.be/qpxhgby-ONI

On this week's episode, listener and reviewer Rusty joins us for his review of the Canik TP 9 Elite SC. We have some discussion on the Surefire XSC weaponlight, The new Viridian HS1 laser handstop, and the Galil ACE pistol in 5.56. We also get to some listener feedback and questions. For all the show … Continue reading "Gun and Gear Review Podcast Episode 340 – Canik review, XSC light, HS1 laser, 556 Galil ACE"

There are calls for the government to provide Eurostar with more support after the company revealed it doesn't plan to stop in Kent again until 2022. Passengers can't get on or off the high speed service at Ebbsfleet or Ashford and it's feared it could have a devastating impact on the county's economy. Hear from local democracy reporter Ciaran Duggan who's been chatting to the head of HS1. Also in today's podcast, we hear from a bride who's hastily rearranged her wedding to avoid having to cut the number of guests when new restrictions come into force on Monday. A plaque has been unveiled at Chatham railway station to an equality pioneer. And, we look ahead to Gillingham's next game in league one - they welcome Blackpool this weekend.

On this week’s episode, listener and reviewer Rusty joins us for his review of the Canik TP 9 Elite SC. We have some discussion on the Surefire XSC weaponlight, The new Viridian HS1 laser handstop, and the Galil ACE pistol in 5.56. We also get to some listener feedback and questions. For all the show … Continue reading "Gun and Gear Review Podcast Episode 340 – Canik review, XSC light, HS1 laser, 556 Galil ACE"

On this week’s episode, listener and reviewer Rusty joins us for his review of the Canik TP 9 Elite SC. We have some discussion on the Surefire XSC weaponlight, The new Viridian HS1 laser handstop, and the Galil ACE pistol in 5.56. We also get to some listener feedback and questions. For all the show … Continue reading "Gun and Gear Review Podcast Episode 340 – Canik review, XSC light, HS1 laser, 556 Galil ACE"

Interview with George Frangeskides, Executive Chairman of Alba Mineral Resources (AIM:ALBA)We last spoke to Frangeskides in October. How have things developed since then for Alba Mineral Resources?Alba Minerals Resources is a small but multi-faceted UK-listed company. The company's projects range from the Horse Hill and Brockham oil & gas projects in England, along with polymetallic, multi-mineral projects in Greenland (4), Wales (1), and Ireland (1). Specific commodities of focus include graphite, iron ore, copper, gold, titanium (ilemnite), zinc, and lead. Talk about commodity diversification!Horse Hill is in production (1 & 2). The drilling was successful, bar a water issue. The vertical project is claimed to hold advantages over horizontal projects: around 2-3X. This is all on hold for the time being. The real mainstay is "HS1," which has been producing 250-300 barrels per day. Alba holds an 18% interest in Horse Hill Developments Limited, the owner of a 65% participating interest and operator of the Horse Hill oil and gas project. There is 25-years of planning permission and there is long-term consent from the Oil and Gas Authority (OGA). All of the regulatory work appears to be in place. The plans are to ramp up production to make it more profitable, but this is impossible right now because of the COVID-19-induced oil market crash. Alba Minerals hasn't been putting money into it as of late, but this could turn into a solid cash flow eventually. At the right price, Frangeskides would look to exit on favourable terms. Does the multi-asset, multi-jurisdiction model derisk things, or has Alba Minerals put its eggs in too many baskets? Frangeskides believes it is worth GB£5-5.5M.We then wanted to talk about the 90%-owned Clogau Gold Project in Wales. Alba Mineral Resources has the right to ascend to 100% ownership. The mine closed in 1998, but historically produced 80,000oz, making it the U.K's largest-ever gold producer. Historically, it is claimed that Clogau gold has been found in exceptionally high-grade pockets, with 'bonanza grades 'running from 10-100oz/t gold. In addition, one of the big marketing strategies has been the Welsh gold thematic: Alba Minerals Resources claims that Welsh gold can attract a 'significant' premium on the gold spot price: around a 2 to 3 multiple due to scarcity value. Is this nothing more than a marketing strategy, or is this substantial? The aim is to leverage existing historical data with modern technology, creating a well-positioned, high-grade, low-cost gold mine. Clogau was purchased for c. GB£1M, mainly in shares. Frangeskides doesn't think Alba Mineral Resources needs to produce as much as 80,000oz gold pa in order to make the operation exciting and profitable. 5,000-10,000oz pa would be enough. Welsh gold was last sold at specialist auctions and fetched 8-10X spot price rates in small quantities. Frangeskides is adamant: there is a market here. There are competitors out there, but Frangeskides would be looking to produce high-end, bespoke items that would fetch a "massive premium."What does the cash situation look like? Frangeskides claims the cash situation is sensitive, and that he can't discuss the numbers. What he can say is that in February, his company secured up to GB£1.1 million of funding from US-based institutional investment fund Bergen Global Opportunity Fund LP. Given the way the market has moved, this looks to have been a smart move.Moving forward, it appears there is little Alba Mineral Resources can do until the market becomes more favourable.  Company page: https://www.albamineralresources.com/Make smarter investment decisions, subscribe here: https://www.cruxinvestor.comFor FREE unbiased investment information, follow us on Twitter, LinkedIn and Facebook:https://twitter.com/cruxinvestorhttps://www.linkedin.com/company/crux-investor/https://www.facebook.com/cruxinvestorTake advantage, hear it here first: https://www.youtube.com/CRUXinvestor

Climb aboard our new episode!! Louis’ world tour started! We break down his stage design and setlist song by song. What did we think of the covers? Did he choose the right 1d songs? What songs were missing? We discuss Niall’s GQ interview and all his snazzy outfits! Finally we dive into Harry’s NPR and Howard Stern interviews (hold tight because we get very feministyyyy!!). Check out Talk Direction Down Low on patreon.com/talkdirection for EXTRA PODCAST CONTENT!! This week we compare HS1 to HS2 and force ourselves to pick which songs are our favorites! Get in touch with us! talkdirection.tumblr.com talkdirection@gmail.com twitter// @talk_direction instagram// @talkdirection FOLLOW CAITLIN: @caitlinirfoster on twitter & instagram FOLLOW LUCIA: @lucciaoh on twitter & instagram

This week KentOnline's podcasting duo look at the political developments affecting the county. Political editor Paul Francis and Oliver Kemp discuss smart motorways, the shortcomings of HS1 and waving goodbye to our MEPs. They also talk about the strange battle of the political banners over the past week.

LIGHTS UP IS HERE! We talk about everything relating to the start of the #HS2 era -- fashion, twitter headers, fonts, the “Do You Know Who You Are?” posters & website, merch, and OF COURSE the FABULOUS BOP that is Lights Up! We break down the song’s lyrics about identity, talk about Harry’s vocal on this song compared to songs on #HS1, and discuss the more drum and bass heavy music. We are in LOVE with this JAM from Harry and we can’t wait to see what he has in store for us in this new era. We wrap up the episode by making predictions about Harry’s upcoming album and how it will compare to his debut album. Check out Talk Direction Down Low on patreon.com/talkdirection for EXTRA PODCAST CONTENT!! This week on TDDL we talk about all things AUTUMN! Get in touch with us! talkdirection.tumblr.com talkdirection@gmail.com twitter// @talk_direction instagram// @talkdirection FOLLOW CAITLIN: @caitlinirfoster on twitter & instagram FOLLOW LUCIA: @lucciaoh on twitter & instagram

This week we geek out over all the pics/vids we've been getting of the upcoming HS2 AND NH2 !!!! We listen to the snippet of Niall's song "Put A Little Love On Me," speculate on what his upcoming single "Nice To Meet Ya" will sound like, and of course we talk about all the Harry clips and try and figure out what it all means. Car crashes, ocean dreamlands, mermaids, connections to HS1, our minds run wild! Check out Talk Direction Down Low on patreon.com/talkdirection for EXTRA PODCAST CONTENT!! This week on TDDL we talk about the 5 Love Languages and we take a quiz to tell us ours! Get in touch with us! talkdirection.tumblr.com talkdirection@gmail.com twitter// @talk_direction instagram// @talkdirection FOLLOW CAITLIN: @caitlinirfoster on twitter & instagram FOLLOW LUCIA: @lucciaoh on twitter & instagram

Buckle up for our last #HS1 song discussion. This week we delve into Sweet Creature: unconditional love, comparisons to 1D’s Strong, plucky guitars, and the rawness of Harry’s voice. Plus we discuss LOUIS: song teaser trailers, possible upcoming live performances, single release date, and his upcoming interviews in two different magazines. It seems like #LT1 is actually coming SOON! We hypothesize about his song Two of Us and try to figure out why he removed and then re-uploaded the picture of him playing piano. Check out Talk Direction Down Low on patreon.com/talkdirection for EXTRA PODCAST CONTENT!! This week we discuss Niall and Julia Michaels' performance of What a Time on the Late Late Show with James Corden and what it was like for Lucia and Caitlin to meet for the first time in Boston! Get in touch with us! talkdirection.tumblr.com talkdirection@gmail.com twitter// @talk_direction instagram// @talkdirection FOLLOW CAITLIN: @caitlinirfoster on twitter & instagram FOLLOW LUCIA: @lucciaoh on twitter & instagram

Life With Herpes https://youtu.be/UoHz1iwTv7E Hi guys and welcome to today's episode. I’m getting a ton of questions on genital herpes and oral herpes and it can be pretty confusing so today I want to spend some time on HS1 when it’s down there. A lot of questions I hear are: “I have HSV1 but I also have genital herpes, so does that mean I have HSV2 also?” “I have HSV1 but I don't get cold sores.” “If I have HSV1 down there can my partner get it on their mouth?” “I’m confused because I have genital herpes but HSV1 is oral herpes.” In general, we are told to think oral herpes is only HSV1 and it can only be around your mouth and the “other” kind is genital herpes and its HSV2. This is 100% false and really they are no different from each other.  For the sake of understanding, today’s message let’s get away from associating oral herpes with HSV1. Let's just use HSV1 and HSV2. With fun sexual activities like oral sex, herpes can be transmitted from someone orally to their partner genitally or visa versa genially to their partner's mouth.  This is why so many people are getting oral herpes down there. To make sure we all know how common herpes is, ⅔ people have HSV1 and ⅙ people have HSV2. These statistics show there are more people with HSV1 and therefore it’s very common to be diagnosed with genital HSV1. It’s important to find out from your doctor when you are diagnosed with herpes if it’s HSV1 or HSV2. This way you can have a conversation with your partner and your potential future partners. For example, if partner A has HSV1 genitally and partner B has HSV2 genitally they can transmit herpes to each other because they are different strains of the virus. I’ve seen this actual situation happen to a number of couples and then boom...a whole new outbreak.   So the bottom line is HSV1 and HSV2 can go wherever you give it a place to go. The previous categories of genital vs oral are not specific enough and in order to fully communicate with our lovers we need to know what strain and where we have it. DM me if you have any questions on this topic or need some clarification. See you next week. Xoxo, Alexandra Here’s How I Can Support Join our monthly live Herpes Support Group - www.lifewithherpes.com/supportgroup Herpes Outbreak Toolkit - https://lifewithherpes.com/herpes-outbreak-toolkit Emergency Call - https://lifewithherpes.com/emergencycall/ Keep in touch with Alexandra Harbushka www.lifewithherpes.com www.instagram.com/alexandraharbushka www.facebook.com/lifewithherpespodcast   www.pinterest.com/lifewithherpes Join The Live With Herpes Community If you are ready to join a community of people who are living with herpes also then you will want to join our slack group. It is FREE and it is a great way to find the support and comfort that you are looking for. Head on over to www.lifewithherpes.com and join our community. You will receive a slack invitation as soon as you sign up. See you in there. Ways You Can Support The Life With Herpes Show If you enjoyed this episode as much as we enjoyed making it for you than  a subscribe would be a great idea. Are you a YouTuber? Go ahead and subscribe to the show. It is a way to pay it forward to fellow friends who are living with herpes. When you subscribe it helps the algorithm in YouTube and it helps promote the show. If you are worried about your identity and your friends finding out you subscribed to a herpes channel then change your settings to private. And trust me I totally get it and would want to keep it a secret. Also, when you subscribe you will be notified in your inbox when a new episode is out or when Alexandra is live on Youtube Live. Subscribe Here Are you a podcast listener? Please give the Life With Herpes show a review. It is a way to pay it forward to fellow friends who are living with herpes. You can Subscribe, Rate and Review the show through your iTunes app or on the desktop. Seriously, it helps out a lot more than it is a hassle for you. You see, iTunes has an algorithm that organically promotes the show, so the more ratings and reviews the Life With Herpes Show receives then the higher it gets ranked. This is your way of paying it forward and helping someone find the show who really needs it. Oh, and you can totally use a fake name, so don’t worry about a friend finding you in the iTunes review. Talking about herpes needs to be spread as far and wide as possible. You are totally a part of this movement so THANK YOU!   Subscribe, Rate and Review

Hanging high under a famous roof, the huge white dial and gold hands of the St Pancras station clock does its job telling travellers the time. But did you know it has also travelled and has its own surprising story to tell? Jean Jacyna of the Camden Tour Guides Association pieces together the story with help from Josie Murray, Senior Heritage Advisor at HS1, Ian and Pam Thompson from Nottingham and the former curator of the British Horological Institute Museum, Viscount Alan Middleton. Written and presented by Jean Jacyna Produced by Freddy Chick The BHI museum is open every Friday from 26 May to 8 September 11am-3pm (£3 entry). http://www.bhi.co.uk/museum Camden Tour Guides Association :: BHI Museum :: Back to homepage :: Follow us on Twitter :: File Download (12:53 min / 12 MB)

The government is stepping up its support for HS2, the high-speed rail project due to link London and Birmingham by 2026 with extensions to Manchester and Leeds by 2032. The cost is officially estimated to be £42.6bn and could rise to more than £51bn if, as expected, the scheme incurs VAT. Opponents foresee further increases and have predicted an eventual bill of £80bn for taxpayers.Who stands to gain from the project and who will be the losers? The government has published detailed maps of the route to be taken by the first stage, leading to calamitous falls in the value of many nearby properties. Towns and cities which are near the route but not linked to HS2 fear that their economies will suffer as businesses are attracted to Birmingham and the northern ends of the line. Current fast train services are due to suffer drastic cuts in the wake of HS2 and some major development plans are now deemed to be at risk.Meanwhile, economic advisers in the three major cities are planning for billions of pounds worth of benefits as travel-times and congestion on the existing network are reduced.Gerry Northam reports from areas which expect to benefit from HS2 and those which could lose out and asks what lessons can be learned from the impact of Britain's first high-speed rail project - HS1 in Kent.Producer: Ian Muir-CochraneEditor: David Ross.

The view from the top of business. Presented by Evan Davis, The Bottom Line cuts through confusion, statistics and spin to present a clearer view of the business world, through discussion with people running leading and emerging companies. The programme is broadcast first on BBC Radio 4 and later on BBC World Service Radio, BBC World News TV and BBC News Channel TV. This week Evan and his panel consider the secrets of a happy business marriage - those key symbiotic partnerships companies have with each other. They also discuss whether flat organisations work best. Joining Evan in the studio are Mike Roney, chief executive of business supplies distributor Bunzl; James Reed, chairman of recruitment specialist Reed; Nicola Shaw, chief executive of HS1, the fast rail link from London to the Channel Tunnel. Producer: Ben Crighton Editor: Stephen Chilcott.

The OSTL gene is localized at the band q23 in the chromosome 6. Its localization corresponds to a translocation breakpoint between chromosomes 6 and 12, the t(6;12)(q23;p13), that was characterized in our group in an acute lymphoblastic leukemia cell line. This translocation involves the ETV6 (translocation ETs leukemia) gene localized in chromosome 12 with the STL (six twelve leukemia gene) gene localized in chromosome 6. The STL gene shares the first exon with a novel gene, that we named OSTL (opposite STL), but they are transcribed in opposite directions. Since the fusion gene ETV6/STL encodes only for a very small protein which lacks any known functional domain, we speculate that the main leukemogenic effect of this translocation is the deregulation of OSTL. OSTL has a RING-Finger motif that is highly conserved between species and has a significant homology with other genes in human as well as C. elegans, D. melanogaster, and S. cerevisiae. OSTL showed a very specific expression pattern during the mouse embryogenesis. The aim of this project was the functional characterization of OSTL, with special emphasis in normal hematopoiesis and leukemogenesis. Therefore we have sequenced the whole human and mouse OSTL cDNA by using OSTL cDNA clones from the RZPD (“Resource Zentrum Primäre Datenbank”) in Berlin. These sequences encode for a 307 (mouse) and a 275 (human) amino acids length protein. The protein length differences between human and mouse are explained because of the existence of alternative spliced exons. The homology between human and mouse sequence is 99% at the protein level. The expression of GFP-OSTL fusion protein in mouse fibroblast cell line enable us to observe the subcellular localization of OSTL protein. GFP-OSTL is localized mainly in the cytoplasm, showing small spots, probably in the mitochondrial region. In a mouse multiple tissue Northern blot, we could show that OSTL is expressed in testis, ovary and liver. In an human multiple tissue Northern, OSTL expression was observed in skeletal muscle, testis, ovary, heart, placenta, pancreas and prostate. Northern blotting with different human cell lines revealed expression of OSTL in three EBV (Epstein Barr Virus) transformed lymphoblastoid cell lines (LCL B, LCL D, and LCL R) and in one NHL (Non-Hodgkin Lymphoma) cell line (Karpas 422). In Reverse Transcriptase PCR experiments using B cell in different maturation stages, the expression of OSTL was observed in naive, memory B and plasma cells, and in leukemic patient samples, expression was observed in several AML and ALL cDNAs. Whole mount in situ hybridization experiments were performed to investigate the temporo-spatial expression pattern of OSTL during mouse embryogenesis. There was distinct expression of Ostl in the somites (myotome), first and second branchial arches, optic and otic vesicles, in the hair follicles of the vibrissae, and limb buds in mouse embryos of embryonal days 9.5 to 14.5. This expression pattern suggests an important role for Ostl in the early development of these structures. Aiming to find protein interaction partners of OSTL, we performed a Yeast Two Hybrid assay using a Hela cDNA library. Among others we found interaction of OSTL with the antiapoptotic protein, HAX-1 (HS1-associated protein X-1), that is involved in the regulation of B-cell signal transduction, and interaction with the pro-apoptotic protein, SIVA. SIVA was originally identified as an interaction partner of CD27 (TNFRSF7), a member of the TNF-receptor superfamily, which is expressed in B cells. These interactions were confirmed by in vitro (cotransformation in yeast, CoIP) and in vivo (colocalization of these proteins in mammalian cells and CoIP) assays. Overexpression of Ostl in primary mouse hematopoietic cells followed by injection of the cells into lethally irradiated mice resulted in a T-Acute-Lymphoblastic-Leukemia (T-ALL) phenotype. In summary, our experiments could demonstrate that OSTL is important in B cell development and signaling and deregulation of this gene can contribute to the development of hematologic malignancies.