Podcast appearances and mentions of Jocelyne Bloch

durée : 00:09:55 - L'invité de 7h50 - par : Helene Fily - Grégoire Courtine, professeur à l'école polytechnique de Lausanne et Jocelyne Bloch, neurochirurgienne, étaient les invités de France Inter ce jeudi. Ils dirigent le centre de recherche NeuroRestore, qui fait remarcher des personnes paraplégiques.

durée : 00:09:55 - L'invité de 7h50 - par : Helene Fily - Grégoire Courtine, professeur à l'école polytechnique de Lausanne et Jocelyne Bloch, neurochirurgienne, étaient les invités de France Inter ce jeudi. Ils dirigent le centre de recherche NeuroRestore, qui fait remarcher des personnes paraplégiques.

Réparer la moelle épinière : l'espoir de remarcher pour les personnes paralysées existe. On en parle avec Grégoire Courtine, professeur à l'école polytechnique de Lausanne, et Jocelyne Bloch, neurochirurgienne.Tous les soirs du lundi au vendredi à 19h sur France 5, Anne-Elisabeth Lemoine et toute son équipe accueillent celles et ceux qui font l'actualité du jour.

Nos invités du jeudi 24 avril 2025 : Affaire Bétharram : la fille de François Bayrou, Hélène Perlant, parle pour la première fois à la télévision aux côtés de Alain Esquerre, porte-parole de l'association des “Victimes de Bétharram”. Recherche sur la moelle épinière: Grégoire Courtine, professeur à l'école polytechnique de Lausanne, et Jocelyne Bloch, neurochirurgienne. Avec également comme chaque soir L'édito de Patrick Cohen, le 5 sur 5 de Lorrain Sénéchal.Tous les soirs du lundi au vendredi à 19h sur France 5, Anne-Elisabeth Lemoine et toute son équipe accueillent celles et ceux qui font l'actualité du jour.

Mercredi 18 décembre 2024, SMART TECH reçoit Jocelyne Bloch (cofondatrice, Onward Medical) et Grégoire Courtine (cofondateur, Onward Medical)-----------------------------------------------------------------------SMART TECH - Le magazine quotidien de l'innovationDans SMART TECH, l'actu du numérique et de l'innovation prend tout son sens. Chaque jour, des spécialistes décryptent les actualités, les tendances, et les enjeux soulevés par l'adoption des nouvelles technologies.

We are at a turning point for brain-computer interfaces (BCIs) and neurotechnology. We have all witnessed phenomenal progress in this field recently via images shared by Neuralink, showing paralyzed patients who can communicate with a computer through their own thoughts. Other fascinating applications, such as those being worked on by Gregoire Courtine and Jocelyne Bloch, enable paraplegics to regain an unprecedented degree of walking mobility. These advancements are mind-blowing and illustrate the potential of these technologies to address conditions that have a major impact on quality of life. What if we were to enhance the physical properties of these implants while making them more accessible in terms of costs to health systems? Where could this paradigm shift take us, and what prospects could it open up for treating complex neurological disorders? This is what we explore in this episode with Carolina Aguilar, CEO of Inbrain Neuroelectronics, a company developing a cutting-edge neural platform based on graphene, promising to change the way we decode, modulate, and stimulate neuronal activity. We talk with Carolina about: How Inbrain Neuroelectronics' technology enhances the resolution of BCIs and their therapeutic potential The stakes around BCIs and their promise in treating serious neurological disorders The importance of focusing their development around therapeutic indications vs. aiming for human augmentation The commercialization of these solutions through a value-based care approach and key success factors Empowering women in science and business An outlook on the future of brain therapies that bridges the gap between reality and science fiction! Timeline: (00:03:22) - Explaining Inbrain Neuroelectronics' neural platform (00:07:32) - The medical need for BCIs and the first indications targeted by Inbrain Neuroelectronics (00:18:46) - Risks around BCIs and ethical considerations for the field to head in the right direction (00:26:17) - Toward value-based commercial models for BCIs (00:29:40) - Transitioning from Medtronic to an early-stage Medtech startup (00:33:29) - Empowering women in science and business What we also talked about with Carolina: Neuralink Elon Musk Sapiens Steering Brain Stimulation Medtronic ONWARD Medical Precision Neuroscience Paradromics Synchron Neurosoft Bioelectronics We cited with Carolina some of the past episodes from the series: #6 - Bringing back walking to paraplegics - Jocelyne Bloch - .NeuroRestore As mentioned by Carolina during the episode, you can access Inbrain Neuroelectronics' publications here and learn more about their ongoing research and therapy development efforts. You can listen to the Neurotech Pub podcast hosted by Matt Angle here. Feel free to follow Inbrain Neuroelectronics activities on LinkedIn. If you want to contact Carolina, you can reach out to her over LinkedIn. If you want to give me feedback on the episode or suggest potential guests, contact me over LinkedIn or via email at mathieu@impulsepodcast.com! If you liked the episode, please share it, subscribe to the podcast, and leave a 5-star review on streaming platforms!

Dans ce numéro du Journal des biotechs, Jocelyne Bloch et Grégoire Courtine,cofondateurs de Onward, présentent la medtech qui a pour ambition de permettre à certaines personnes paralysées de recouvrer l'usage de leurs jambes. Science, technologie, taille du marché, développements en cours : ils abordent les différents points de l'actualité de Onward et ses perspectives.

Neuroimplante contra el Parkinson / FFMpeg multi-hilo / Primer misil derribado en el espacio / Datacenters calentando 10.000 hogares / Apple cancela iMac 27 Patrocinador: El proyecto CRECE de Cruz Roja es una nueva iniciativa para luchar contra la soledad no deseada. Es un proyecto innovador desde el punto de vista tecnológico y social, con el objetivo de diseñar y probar nuevos métodos de ayuda social que eviten la institucionalización. — Si te encuentras en esta situación, quieres colaborar o ser voluntario, apúntate. Neuroimplante contra el Parkinson / FFMpeg multi-hilo / Primer misil derribado en el espacio / Datacenters calentando 10.000 hogares / Apple cancela iMac 27

How would the world look like if men had the most efficient and reversible means of birth control? The outstanding work that L.R. Fox and his team at NEXT Life Sciences are leading might bring a very tangible answer to this question. Based on the pioneering work from Prof. Sujoy K. Guha and The Parsemus Foundation, they are developing one of the most promising male birth control methods medicine has ever known, under the name of Plan A. As an American citizen who has grown under the Foster Care program, Fox (as he likes to be called) has witnessed firsthand the dramatic consequences that unplanned pregnancies can have on individuals and their relatives in the long term. According to him, we have gone quite far already in terms of available options for women and men when it comes to birth control methods. But Plan A could be a revolution in the space, as it is completely hormone-free, painless to deliver and revert, and has an efficacy duration that is way beyond current standards. And most importantly, it can redistribute the heavy responsibility of family planning from women to men. In this episode, we talk about the science behind Plan A, where the technology comes from, how far is it from being available worldwide, and what it would change for society as a whole! A fascinating conversation with a visionary founder, deeply led by the purpose of fostering a positive impact in the world, and with a strong social approach to entrepreneurship! Timeline: 02:35 - Fox's background and how he landed in the field of male contraception 06:16 - Experiencing firsthand the consequences of unplanned pregnancies 09:34 - The mission of NEXT Life Sciences 11:50 - The need, the science, and the functioning of Plan A 16:02 - How the Plan A procedure works and gets reverted 25:02 - Guaranteeing a 10-year efficacy claim 26:56 - Launching the first human clinical trials 33:55 - Making it accessible to the broadest population 38:17 - The philosophy of Fox and NEXT Life Sciences What we also talked about with Fox: Sexually transmissible diseases (STDs) Condoms Vasectomy Reversible inhibition of sperm under guidance (RISUG) Plan B Public benefit corporation We cited with Fox some of the past episodes from the series: #6 - Bringing back walking to paraplegics - Jocelyne Bloch - .NeuroRestore You can learn more about NEXT Life Sciences through their website, and feel free to follow their activities on LinkedIn! As mentioned by Fox during the episode, you can learn more about Plan A on the dedicated website as well as on Instagram, X, Facebook, and TikTok. If you want to contact Fox, you can reach out to him over LinkedIn. If you want to give me feedback on the episode or suggest potential guests, contact me over LinkedIn or via email at mathieu@impulsepodcast.com! If you liked the episode, please share it, subscribe to the podcast, and leave a 5-star review on streaming platforms!

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Restoring one of our five senses, in this case, touch. The stakes are immense (1 in 1000 people are affected yearly by a peripheral nerve injury!) and the origins are diverse: traumatic accident, cancer, amputation, and many others. And solutions to this problem have long needed to be improved. Karen Zaderej and her team at Axogen have set themselves the goal of changing this situation, by proposing new ways of treating nerves, taking advantage of their regenerative potential. A chemical engineer by training, Karen began her career at Johnson & Johnson in its surgical solutions subsidiary, ETHICON. With 17 years of experience in roles ranging from manufacturing to product development and sales, she decided to leave her corporate career behind. In 2006 she joined a Floridian start-up in its infancy, developing a new type of medical device enabling nerves to regenerate, still at the prototype stage and not yet tested on humans. The outcome? A company that has become a world leader in the development of cutting-edge nerve repair solutions, listed on the stock exchange and now employs over 400 people. In this new episode, we delve into the world of peripheral nerves, the source of our physical and motor sensations, and their formidable regenerative capacities. You will learn about: How our nerves work and current approaches to repairing them Phantom pain, how to explain it, and how to treat it How women today can regain sensation in their breasts following a mastectomy The journey of a remarkable woman entrepreneur who has made addressing nerve damage her life mission Prepare to be nervously amazed as we unravel the secrets of touch restoration! Timeline: 00:03:00 - Karen's background as a nerve evangelist 00:07:35 - Key evolutions in medical technology that Karen witnessed 00:10:42 - What Karen learned at J&J that shaped the rest of her career 00:15:43 - What attracted Karen to Axogen and the potential of their technology 00:20:40 - Scaling up a medical device company from a very early stage onwards 00:23:15 - How Axogen enables nerve repair 00:27:18 - Bringing an answer to phantom pain 00:30:47 - The main indication areas covered by Axogen 00:38:31 - What the future of nerve repair might look like What we also talked about with Karen: Autograft Allograft Mastectomy Neuroma Da Vinci Surgical Systems We cited with Karen some of the past episodes from the series: #6 - Bringing back walking to paraplegics - Jocelyne Bloch - .NeuroRestore #2 - Treating liver cancer with surgical robotics - Lucien Blondel - Quantum Surgical You can learn more about Axogen through their website and their portfolio here. Feel free to follow as well their activities on LinkedIn, Twitter, and Facebook! As mentioned by Karen during the episode, you can find out more about clinical research in peripheral nerve repair through the complete library of published papers curated by the company. Karen also invites you to consult resensation.com and rethinkpain.com to hear about patient stories and find resources in case you face a similar situation. If you want to get in touch with Karen, feel free to contact her over LinkedIn. If you want to give me feedback on the episode or suggest potential guests, feel free to do so contact me over LinkedIn or via email at mathieu@impulsepodcast.com! If you liked the episode, please share it, subscribe to the podcast, and leave a 5-star review on streaming platforms! Follow also our activities on LinkedIn and through our website!

A tour de force, a dynamic duo, a powerful pair … somehow these phrases are not adequate when describing the incredible work of Dr. Grégoire Courtine and Dr. Jocelyn Bloch. Their remarkable discoveries in the field of spinal cord injury are bringing treatments to the forefront - using a brain-spine interface to facilitate movement for those living with paralysis. With the help of their dedicated team of scientists, what we once hoped for is now a reality. This is exciting stuff. Prepare to be amazed!Dr. Jocelyne Bloch is a neurosurgeon at the University Hospital Lausanne, Switzerland, also known as CHUV, where she leads the Functional Neurosurgery Unit. Dr. Grégoire Courtine is a neuroscientist with a background in physics.Both Dr. Bloch and Dr. Courtine are professors within the NeuroX Institute of the Ecole Polytechnique Fédérale de Lausanne (EPFL), within the Neurosurgical Department of CHUV, and at the Faculty of Medicine of the University of Lausanne (UNIL).They co-founded the Defitech Center for Interventional Neurotherapies, named NeuroRestore, which they lead together as Co-Directors. NeuroRestore is a research, innovation, and treatment center that develops and applies bioengineering strategies involving neurosurgical interventions to restore neurological functions. https://www.neurorestore.swiss/In 2014, Dr. Bloch and Dr. Courtine also co-founded ONWARD Medical with the aim to translate the neurotherapies developed at NeuroRestore into clinical treatments. Dr. Courtine is Chief Scientific Officer (CSO) of ONWARD Medical N.V. (Euronext: ONWD). https://www.onwd.com/They are recognized worldwide for their conception of neuroprosthetic implants that restored walking in people with chronic paralysis, the results of their research have been published in numerous articles by science and nature journals, and broadly publicized in print and broadcast media across the world.Thank you again to both Dr. Bloch and Dr. Courtine for joining us for today's episode! This production is a collaborative effort of volunteers working to create a quality audio and visual experience around the subject of spinal cord injury. A special shout out of appreciation to Clientek for providing studio space and top-notch recording equipment. Most importantly, thank YOU for being part of the Spinal Cast audience!Interested in watching these episodes?! Check out our YouTube playlist! - https://youtube.com/playlist?list=PL40rLlxGS4VzgAjW8P6Pz1mVWiN0Jou3vIf you'd like to learn more about the MCPF you can visit our website - https://mcpf.org/Donations are always welcomed - https://mcpf.org/you-can-help/

Gert-Jan Oskam quedó paralítico tras un accidente en 2011. Ahora, gracias a una interfaz que conecta su cerebro con su espina dorsal está aprendiendo de nuevo a caminar.

A paralyzed man can walk again after an experimental operation performed by neurosurgeons in Switzerland. Thanks to brain implants, AI, and electrodes in his spinal cord, the patient can now move his legs again.

Ein gelähmter Mann kann nach einer experimentellen Operation Schweizer Neurowissenschaftler wieder laufen. Dank Hirnimplantaten, KI und Elektroden im Rückenmark kann er wieder seine Beine bewegen.

How do our brains change as we get older? Why are we more likely to develop Alzheimer's or experience a stroke late in life? And what can you do to help protect your neural health? In this episode of How We're Wired, join evolutionary anthropologist Dr Anna Machin as she unpicks the neuroscience behind the mature brain, from the neural changes that makes most of us more forgetful, to strides in repairing brain tissue after stroke. With special thanks to Sue, Alexandra Touroutoglou, and Jocelyne Bloch. How We're Wired is a Fresh Air Production for The Bertarelli Foundation. Follow now so you never miss an episode. For information and support regarding stroke https://www.bhf.org.uk/informationsupport/conditions/stroke To listen to the Ticker Tapes podcast https://www.bhf.org.uk/informationsupport/support/podcasts  See omnystudio.com/listener for privacy information.

En este episodio especial nos acompaña Daniel Pérez Marcos, un doctor en ingeniería biomédica trabajando en neurotecnología en Lausana, Suiza, y creador del podcast Pasando la Cuarentena. Hoy hablamos con él de las lesiones medulares, aquellas que ocurren principalmente después de accidentes, de moto, coche, caídas graves, etc., y en las que se daña la médula espinal, y de cómo se están creando posibles mejoras para los pacientes por medio de implantes medulares. Estas lesiones tienen consecuencias devastadoras, sobre todo físicas, para la persona. A todos nos suena el término parapléjico/a, y lo asociamos a gente en silla de ruedas. Pero, ¿qué significa exactamente? ¿En qué consiste la lesión? En un laboratorio de la EPFL en Lausana, Suiza, dirigido por el científico Gregoire Courtine y la neurocirujana Jocelyne Bloch, se llevan a cabo estudios clínicos que tienen como objetivo restaurar las funciones motoras en personas con lesión crónica de la médula espinal. Repasamos la historia de esta lesión, qué se ha hecho en el pasado para mejorar las perspectivas vitales de quien la sufre, y en qué se está trabajando de cara al futuro. Nos centraremos en los implantes medulares, dispositivos capaces de estimular e incluso regenerar la médula espinal. Aquí tenéis un vídeo en YouTube con el que Grégoire Courtine explica su proyecto y muestra un caso de éxito: https://www.youtube.com/watch?v=fihWjdRCcOo Finalmente, nos preguntamos si iniciativas como Neuralink de Elon Musk pueden ser revolucionarias o si todavía queda mucha tela que cortar. ¡Esperamos que os guste! Música del episodio Introducción: Safe and Warm in Hunter's Arms - Roller Genoa Cierre: Inspiring Course Of Life - Alex Che Puedes encontrarnos en Twitter y en Facebook y apoyarnos suscribiéndote al podcast en Podhero o haciéndote fan en iVoox. Si quieres un mes gratis en iVoox Premium, haz click aquí.

Will the next revolution in personalized health be led by connected clothes? This is the bet that Vincent Martinez and his team at Nanoleq are making, and they are putting all their efforts into turning their vision into reality! Originally, their idea was to target the cable industry with a proprietary technology enabling to create stretchable cables, with superior physical and electrical properties. The targeted companies being too slow in their adoption of the proposed approach, Vincent and his team decide to tackle the field of connected clothing, by proposing a set of components and tools enabling any clothing manufacturer to turn their garments into smart ones, able to measure multiple vital parameters but also to electrically stimulate certain regions of the body. Building upon their expertise in this space, they developed the first breathing smart garment with live biofeedback - Oxa - around which they designed a whole personalized program for everyone to reconnect to their body through breathing, the only vital sign we can consciously control. We talked with Vincent about the emergence of connected clothes and what role they will play in the preservation of our health, how stretchable electronics work, and how Nanoleq managed to develop a full breathing experience combining cutting-edge sensors with gamification, backed by the most renown ambassadors in the field. Timeline: 00:58 - Vincent's background at the interface of materials science and biomedical engineering 02:57 - Launching a company to address the premature breakage of electronic cables 07:45 - What lies behind the term « stretchable electronics » 09:55 - Shifting the focus towards smart textiles 19:48 - The vision of Nanoleq around connected health 24:05 - Starting a new product line focused on breathing optimization: Oxa Life 35:00 - Federating a community of breathing specialists 37:46 - Making the most personalised and digitally engaging breathing optimization program 44:14 - Towards everyday wear of smart clothes What we also talked about with Vincent: ETH Pioneer Fellowships Luca Hirt Grégoire Courtine Start Summit Venture Kick Venture Electrical Muscle Stimulation (EMS) Wim Hof Sleep apnea Dan Brulé Headspace Petit Bambou Andrew Huberman We cited with Vincent some of the past episodes from the series: #6 - Bringing back walking to paraplegics - Jocelyne Bloch - .NeuroRestore #11 - Turning the lab into a wearable platform - Esmeralda Megally - Xsensio As mentioned in the episode, you can learn more about Nanoleq and the field of stretchable electronics through their website. The Kickstarter campaign for Oxa runs until Sunday December 18 and you can contribute to it at this page! For more information about Oxa, check out the official product page: www.oxalife.com. Based on Vincent's suggestions, check out the book Breath from James Nestor or this episode of Huberman Lab if you want to know more about the science behind breathing and the exercises that we discussed in this episode. You can also learn more about the Buteyko method here. If you want to get in touch with Vincent, feel free to contact him per email at martinez@nanoleq.com or through LinkedIn. If you want to give me feedback on the episode, ask questions or suggest potential guests, feel free to do so through LinkedIn or per email at mathieu@impulsepodcast.com. And if you liked the episode, don't hesitate to share it, subscribe to the podcast and leave a positive review on streaming platforms! Finally, you can follow our activities through our website, over LinkedIn, Twitter or on Instagram!

La semaine passée, Elon Musk a annoncé que d'ici six mois sa start-up Neuralink sera en mesure d'implanter son premier appareil connecté dans le cerveau d'un humain. Mais qu'est-ce qu'exactement un implant cérébral? Et quelles sont ses différentes fonctions? Le Point J en discute avec Jocelyne Bloch, médecin chef au CHUV en neurochirurgie, figure incontournable de la neurochirurgie fonctionnelle. Juliane Roncoroni Réalisation: Sylvain Michel Pour aller plus loin: - "Les droits de notre cerveau ou la limite de la vie privée", RTSinfo (en ligne) - "Neil Harbisson : J'écoute les couleurs", chaîne TED sur YouTube Nous écrire: +41 79 134 34 70 (WhatsApp) ou pointj@rts.ch

Dr. Sarah Schaefer speaks with Drs. Gregoire Courtine and Jocelyne Bloch about the use of an implanted spinal cord stimulator for the treatment of orthostatic hypotension in multiple-system atrophy. Read the article.

Bringing back mobility to those who lost it. This is the challenge that Jocelyne Bloch, neurosurgeon at the CHUV, together with the neuroscientist Grégoire Courtine from EPFL and their teams at .NeuroRestore and Onward set out to address. A decade after demonstrating that the technology developed by Prof. Courtine's lab was able to bring back lower limb mobility to paraplegic rats, it has now been applied to humans in a research context through their joint work with phenomenal outcomes: most paraplegic patients implanted with the stimulation system they have developed were able to retrieve significant mobility of their lower limbs, enabling them to stand, walk and even climb stairs! Based on an electrode array coupled to a pulse generator (both fully implantable) remotely controlled, the system delivers selective stimulation of the spinal cord at the locations where the lower limb muscles are activated, in a sequence that replicates the mobility patterns that abled people demonstrate. Images of patients having experienced this technology, moving out of their wheelchair to stand and walk, have been seen throughout the world, and the hope that it brings for those concerned is immense, considering also the other applications that it could open for the rehabilitation of the upper limbs or for blood pressure regulation. In the latest episode from Impulse, we had the chance to sit down with Jocelyne and exchange with her on the infancy of this therapy, where she takes us through its working principle, the challenges that come along with bringing such a technology from the lab to the market, as well as on the life-changing benefits it may hold for patients in the future. With great humility, she also talks about how she manages to combine her clinical practice as a functional neurosurgeon, to leading a research group composed of over 80 collaborators, all of that while raising two children and with a husband at home! Timeline: 05:20 - Jocelyne's background and what led her to functional neurosurgery 08:18 - Approach taken to enable paraplegic rats to walk again and moving towards human applications 14:55 - The first human implantation 17:20 - Towards autonomous mobility renewal 18:25 - The STIMO study focusing on mobility and upcoming trials 21:03 - Managing expectations of patients 23:20 - Making a viable therapy with a reasonable rehabilitation training phase 26:17 - Leveraging potential synergies with exoskeletons 27:23 - Current technological constraints 28:34 - Origins and purpose of .NeuroRestore, and the close collaboration with Onward 33:03 - Towards upper limbs and hands rehabilitation therapies 34:10 - Retrieving sensory feedback thanks to the current therapy 35:23 - Adding brain-computer interaction layers to the current therapy 37:56 - Staying on top of things when working as a neurosurgeon, leading a clinical research center, and a family life 39:41 - Evolving as a woman in the field of neurosurgery What we also talked about with Jocelyne: Grégoire Courtine Patrick Aebischer Jean-Guy Villemure Bogdan Draganski Baroreflex Neuroprosthetics Neuroplasticity EEG ECoG CHUV UNIL EPFL Medtronic Elon Musk We cited with Jocelyne some of the past episodes from the series: #3 – Augmenting the lives of paraplegics with exoskeletons – Tristan Vouga – Twiice #5 – Transforming diagnostics through spatial biology – Déborah Heintze – Lunaphore If you want to know more about .NeuroRestore, we invite you to consult their website. We also invite you to follow their activities on LinkedIn. If you are interested in learning more about the startup Onward, we invite you to check out their website as well as their LinkedIn page. You can contact Jocelyne by email: jocelyne.bloch@chuv.ch If you want to give me feedback on the episode, ask questions or suggest potential guests, feel free to do so through LinkedIn or by email: m.chaffard05@gmail.com.

To discover the whole episode type “#6 - Bringing back walking to paraplegics - Jocelyne Bloch - .NeuroRestore” on your streaming platform.

Has the future of spinal cord injury treatment arrived? On this episode, I sit down with Drs. Gregoire Courtine and Jocelyne Bloch to discuss their recently published and highly publicized paper on restoring motor function after paralysis. They briefly dive into their protocol, their approach to Epi-Stim, and their answer to the magic wand question.You will want to hear this episode if you are interested in...A brief overview of the recent paper published by Drs. Courtine and Bloch [2:43]How Drs. Courtine and Bloch designed their protocol to strengthen residual pathways [5:31] What Dr. Courtine wished he knew 20 years ago [7:46]Dr. Bloch's training and evolution as a neurosurgeon [8:48]Dr. Courtine breaks down his approach to Epi-Stim [10:36]Drs. Courtine and Bloch answer the magic wand question [12:27]Resources & People MentionedActivity-dependent spinal cord neuromodulation rapidly restores trunk and leg motor functions after complete paralysis (Paper)Explaining STIMO (Christopher Reeve Foundation interview) Connect with Drs. Gregoire Courtine and Jocelyne BlochONWARD (Website) Connect With Maxwell Boakyehttps://maxwellboakye.com/podcast Like on FacebookFollow on TwitterFollow on LinkedInDrMaxBoakye (at) Gmail.com

New Device Helps People With Paralysis Walk Again Spinal cord injuries are notoriously difficult to treat, especially for those who have been paralyzed for several years. Now, researchers have developed a new implant that is able to reverse paralysis in patients with complete spinal cord injuries. The device uses specially designed electrodes, which bring the brain back into communication with the patient's lower body. The findings were recently published in the academic journal Nature Medicine. Ira talks with the study's co-authors, Jocelyne Bloch, a neurosurgeon at Lausanne University Hospital, and Grégoire Courtine, professor of neuroscience at the Swiss Federal Institute of Technology, based in Lausanne, Switzerland.   Could Protein-Based Vaccines Help Close The Global Vaccination Gap? A new generation of COVID-19 vaccines are being developed and distributed around the world. They're called recombinant-protein vaccines. But the tech is actually not at all new. In fact, It's been used to produce hepatitis C and pertussis vaccines for decades. These protein-based vaccines have an edge over mRNA vaccines in a few ways. They're just as effective, cheaper and simpler to manufacture, and easier to distribute. So why, two years into the pandemic, have they just started gaining traction? And can recombinant-protein vaccines help close the global coronavirus vaccination gap? Ira discusses these developments with Dr. Maria Elena Bottazzi, the co-creator of Corbevax, a patent-free protein-based vaccine, for which she was recently nominated for the Nobel Peace Prize. She's also the co-director of the Center for Vaccine Development at Texas Children's Hospital, and a professor at the Baylor College of Medicine, based in Houston, Texas.   How Cuba Developed Five COVID-19 Vaccines Cuba was able to quickly produce five coronavirus vaccines, thanks to the island's robust biotech industry. For decades, Cuba has produced its own home-grown vaccines and distributed them to neighboring countries. But sanctions and political dynamics have complicated Cuba's ability to distribute their COVID-19 vaccines with the world. Ira talks with Helen Yaffe, senior lecturer of economic and social history at Glasgow University, and author of We Are Cuba! How a Revolutionary People Have Survived in a Post-Soviet World.   Fish Make More Noise Than You Think One of the most famous films of undersea explorer Jacques Cousteau was titled The Silent World. But when you actually stop and listen to the fishes, the world beneath the waves is a surprisingly noisy place. In a recent study published in the journal Ichthyology & Herpetology, researchers report that as many of two-thirds of the ray-finned fish families either are known to make sounds, or at least have the physical capability to do so. Some fish use specialized muscles around their buoyancy-modulating swim bladders to make noise. Others might blow bubbles out their mouths, or, in the case of herring, out their rear ends, producing “fish farts.” Still other species use ridges on their bodies to make noises similar to the way crickets do, grind their teeth, or snap a tendon to sound off. The noises serve a variety of purposes, from calling for a mate to warning off an adversary. Aaron Rice, principal ecologist in the K. Lisa Yang Center for Conservation Bioacoustics at the Cornell Lab of Ornithology in Ithaca, walks Ira through some of the unusual sounds produced by known fish around the world—and some mystery noises that they know are produced by fish, but have yet to identify.    

Amidst the aftermath of COVID-19 waiting lists continue to grow for those in need of an organ transplant, whilst simultaneously in an American surgery a man recieves the heart of a pig. Animal donors may be the answer to our shortage of available organs, but the procedure isn't quite ready to become common place. Take a trip down memory lane and embark on the jounrey of transplantation, where it began, where we are right now and what the future might look like in the next decade. Plus, catch up on chimps applying insects to their wounds, the current uses of facial recognition and how tech can... Like this podcast? Please help us by supporting the Naked Scientists

Amidst the aftermath of COVID-19 waiting lists continue to grow for those in need of an organ transplant, whilst simultaneously in an American surgery a man recieves the heart of a pig. Animal donors may be the answer to our shortage of available organs, but the procedure isn't quite ready to become common place. Take a trip down memory lane and embark on the jounrey of transplantation, where it began, where we are right now and what the future might look like in the next decade. Plus, catch up on chimps applying insects to their wounds, the current uses of facial recognition and how tech can... Like this podcast? Please help us by supporting the Naked Scientists

Aaron Phillips, CEP, MSc, PhD (Medicine), Assistant Professor at the University of Calgary, joins host Lauren Richardson to discuss the results and implications of the article "Neuroprosthetic baroreflex controls haemodynamics after spinal cord injury" by Jordan W. Squair, Matthieu Gautier, Lois Mahe, Jan Elaine Soriano, Andreas Rowald, Arnaud Bichat, Newton Cho, Mark A. Anderson, Nicholas D. James, Jerome Gandar, Anthony V. Incognito, Giuseppe Schiavone, Zoe K. Sarafis, Achilleas Laskaratos, Kay Bartholdi, Robin Demesmaeker, Salif Komi, Charlotte Moerman, Bita Vaseghi, Berkeley Scott, Ryan Rosentreter, Claudia Kathe, Jimmy Ravier, Laura McCracken, Xiaoyang Kang, Nicolas Vachicouras, Florian Fallegger, Ileana Jelescu, YunLong Cheng, Qin Li, Rik Buschman, Nicolas Buse, Tim Denison, Sean Dukelow, Rebecca Charbonneau, Ian Rigby, Steven K. Boyd, Philip J. Millar, Eduardo Martin Moraud, Marco Capogrosso, Fabien B. Wagner, Quentin Barraud, Erwan Bezard, Stéphanie P. Lacour, Jocelyne Bloch, Grégoire Courtine & Aaron A. Phillips, published in Nature.

Grégoire COURTINE, professeur associé, Centre des neuroprothèses EPFL et Jocelyne BLOCH, professeure associée, Service de neurochirurgie CHUV

V pretekli epizodi smo že spoznali Davida Mzeeja, ki je pred dobrimi devetimi leti zaradi poškodbe pri gimnastiki postal paraplegik, z neverjetno voljo, razvojem medicine in tehnologije pa danes lahko počne marsikaj, česar si takrat gotovo ne bi niti mislil. Tudi hodi. V tej epizodi bosta o njegovi zgodbi in prihodnosti tovrstne terapije govorila prof. dr. Gregoire Courtine, profesor na Centru za Nevroprostetiko Inštituta Brain Mind v Lozani, ki je razvil posebne elektrode, in prof. dr. Jocelyne Bloch, nevrokirurginja, ki jih je Davidu vstavila v telo. Pripravlja: Mojca Delač.

Bệnh nhân mắc chứng liệt chi dưới do tổn thương tủy sống có thể đi lại được nhờ vào liệu pháp mới « kích thích tủy cột sống bằng xung điện ». Một nhóm các nhà khoa học Thụy Sĩ vừa công bố kết quả công trình nghiên cứu này trên tạp chí khoa học có uy tín Nature ngày 01/11/2018. Một tin vui mang lại nhiều hy vọng cho các bệnh nhân bị liệt chi dưới do các chấn thương tủy sống. Nghiên cứu được thực hiện dưới sự điều hành của ba nhà khoa học lớn : bà Jocelyne Bloch - bác sĩ phẫu thuật thần kinh người Thụy Sĩ thuộc Trung tâm Đại học Y khoa Lausanne (CHUV) ; Grégoire Courtine – giáo sư khoa học thần kinh người Pháp và nhất là Fabien Wagner, kỹ sư người Pháp, người phát triển phần mềm kích thích xung điện. Ông Fabien Wagner còn là người đưa ra ý tưởng cho dự án, bởi vì chính bản thân ông cũng là một người tàn tật. Báo Le Monde (07/11/2018) cho biết thêm cả hai chuyên gia người Pháp hiện đang giảng dạy tại trường đại học Bách khoa Liên bang (EPFL) tại Lausanne, Thụy Sĩ. Tham gia công trình còn có sự đóng góp nhiệt tình của ba bệnh nhân tình nguyện : Sebastian Tobler - 48 tuổi, David Mzee - 30 tuổi và Gert-Jan Oskam – 35 tuổi. Cả ba người này có cùng điểm chung là đều bị chấn thương tủy cột sống sau một tai nạn thể thao dẫn đến tình trạng bị liệt hai chân từ nhiều năm nay. Đây cũng là lần đầu tiên các bệnh nhân tham gia thí nghiệm lâm sàng chấp nhận trả lời báo chí công khai, không giấu danh tính như luật pháp quy định. Phương pháp trị liệu Việc điều trị được thực hiện như thế nào ? Trên đài RFI, bà Jocelyne Bloch trước tiên lưu ý phần não chỉ huy của cả ba bệnh nhân may mắn không bị tổn thương. Điều này cho phép các nhà khoa học tiến hành thử nghiệm liệu pháp xung điện tủy cột sống để phục hồi chức năng vận động. Bà cho biết: « Ba bệnh nhân mà chúng tôi nói đến đều đã bị tổn thương ở tủy cột sống, phần ở giữa lưng. Nhưng não bộ của họ không làm sao và vẫn có khả năng đưa ra các mệnh lệnh. Hai chân của họ cũng như tủy cột sống phần dưới vẫn nguyên vẹn. Vấn đề ở đây là có một sự gián đoạn trong hệ thống dây thần kinh chạy từ não xuống chân. Do vậy, chúng tôi đã dùng điện kích thích vào phần tủy cột sống, phía dưới phần bị tổn thương, để thúc đẩy các cơ bắp hoạt động, tạo thuận lợi cho việc cử động, bước đi. Có nghĩa là phần não chỉ huy vẫn hoạt động tốt, nhưng lại không có đủ các thần kinh sợi để truyền mệnh lệnh, cho phép bệnh nhân đi lại. Việc kích thích điện vào tủy cột sống tạo thuận lợi cho bệnh nhân đi lại.» Trước khi bước vào giai đoạn kích xung điện, cả ba bệnh nhân  phải trải qua một cuộc phẫu thuật. Các bác sĩ sẽ cài đặt một mảnh ghép ở phần thắt lưng, sát với tủy sống, trước điểm bị tổn thương và lắp một máy phát ở lồng ngực. Được điều khiển từ xa qua máy vi tính hay máy tính bảng, chiếc máy phát này sẽ truyền tải đến mảnh ghép các tín hiệu điện để kích hoạt mảnh ghép, để rồi từ đó kích thích các sợi thần kinh điều khiển các cơ chân. Bà Jocelyne Bloch cho biết tiếp : « Điều mới ở đây là chúng tôi đã hiểu được cơ chế cho phép bệnh nhân bước đi. Do vậy, chúng tôi dùng điện kích thích vào các vùng khác nhau của tủy cột sống để lần lượt kích hoạt động tác co, duỗi, tạo dễ dàng cho việc bước đi. Điểm khác biệt lớn là khi luyện tập cho bệnh nhân bị liệt như vậy, chúng tôi nhận thấy là sau vài tuần luyện tập dồn dập, với những bài tập dài, bệnh nhân đã phục hồi được các chức năng cơ bắp, sau nhiều năm bị liệt. » Với ông Gregoire Courtine, thời điểm này có ý nghĩa quan trọng. Việc luyện tập giúp khôi phục lại tính đàn hồi tế bào thần kinh, nghĩa là kích thích khả năng tái tổ chức các đường truyền thần kinh. « Bệnh nhân sẽ phải kích thích các cơ bắp. Cùng một lúc, hoạt động này sẽ kích thích vùng tương ứng ở tủy cột sống. Sự trùng hợp này cho thấy là các sợi thần kinh đang hồi phục ở điểm này », theo như giải thích của ông Gregoire Courtine với báo Le Monde. Đây chính là điểm khác biệt so với các công trình nghiên cứu của Mỹ cũng được công bố trong năm nay.  Ngày 24/09/2018, hai nhóm nghiên cứu của Mỹ – một tại Mayo Clinic (Minnesota) và nhóm thứ hai Susan Harkema, thuộc trường đại học Louisville (Kentucky), nổi tiếng trong lĩnh vực này – cùng loan báo đã làm cho ba bệnh nhân khác bị liệt chi dưới đi lại được. Tuy nhiên, các phương pháp của các nhà khoa học Thụy Điển dường như có phần tinh vi hơn so với các nghiên cứu của đồng nghiệp Mỹ. Các nhà khoa học tại Hoa Kỳ chủ yếu dựa vào việc dùng xung điện kích thích tủy cột sống liên tục, kèm theo một chương trình tập luyện kéo dài. Một chiến lược mà ông Gregoire Courtine đánh giá là « theo kinh nghiệm », chỉ cho phép bệnh nhân « đi lại trong những khoảng cách ngắn, với điều kiện xung điện vẫn đang hoạt động », và nhất là kết quả chỉ đạt được sau nhiều tháng dài hồi phục chức năng. Một cuộc phiêu lưu tương lai Đối với các nhà khoa học và những người tình nguyện tham gia thí nghiệm, chương trình nghiên cứu này chẳng khác gì một cuộc phiêu lưu khoa học và đậm chất nhân bản. Cuộc phiêu lưu này có được nhờ vào sự nhiệt tình và bền bỉ của ba bệnh nhân. Hiếm có một cuộc thí nghiệm lâm sàng nào mà người tham gia dấn thân nhiệt tình đến như thế. Tuổi còn trẻ là một yếu tố quyết định. Ở các bệnh nhân lớn tuổi, việc hồi phục chắc chắn sẽ khó khăn hơn.  Kết quả đạt được còn khiêm tốn, nhưng lại đáng khích lệ. Các nhà khoa học cũng lưu ý là mức độ tự lập của từng bệnh nhân hiện nay vẫn rất khác nhau do tình trạng tê liệt của mỗi người mỗi khác. Có người có thể đi được vài bước không cần xung điện, nhưng hiện tại họ cảm thấy đi lại dễ dàng hơn khi có xung điện và có thể đi đến 2 km. Với kết quả đạt này, các nhà khoa học Thụy Sĩ hy vọng sắp tới sẽ đạt được tiến bộ hơn. Thí nghiệm lâm sàng sẽ được mở rộng ra cho nhiều đối tượng khác. Các tác giả tin rằng nếu được điều trị sớm, khả năng hồi phục chức năng đi lại càng cao và nhanh. Bà Jocelyne Bloch nói: « Đương nhiên, chúng tôi mới chỉ bắt đầu và cố gắng đưa ra một quan niệm. Ý tưởng của chúng tôi là trong tương lai, sẽ áp dụng phương pháp này để chữa trị. Nhưng liệu giới bác sĩ có chữa cho các bệnh nhân bị liệt có thể đi lại được, như chúng tôi đã làm hay không ? Có thể là không và còn cần có thêm các công trình nghiên cứu khác nữa. Nhưng trong mọi trường hợp, giới chuyên gia cần cố gắng để làm việc này một cách tốt nhất. Tôi nghĩ rằng một trong những điều chủ chốt là cần phải bắt đầu chữa trị rất sớm. Trong trường hợp ba bệnh nhân mà chúng tôi miêu tả, thì họ đã trải qua từ 3 đến 7 năm bị liệt sau khi bị chấn thương. Theo tôi, cần phải bắt đầu chữa trị ngay sau khi xẩy ra tổn thương ở tủy cột sống và luyện tập trong những điều kiện tốt nhất. Đó là tiến bộ đầu tiên cần phải đạt được. Điều thứ hai là cần cải thiện hệ thống kích thích để cho bệnh nhân có thể sớm thích ứng với cơ chế vận động của mỗi người và trong lĩnh vực này, cần phải đạt được thêm những tiến bộ kỹ thuật. » Liệu giải pháp này có thể mở rộng sang các bệnh tê liệt vì những nguyên nhân khác ? Về điểm này, bà Jocelyne Bloch khẳng định đây là điều còn hạn chế của các nghiên cứu hiện nay: « Các loại bệnh thoái hóa thì hơi khó bởi vì đó là những bệnh liên tục phát triển. Ngược lại, có những bệnh liên quan đến vận động, chẳng hạn những người bị tai biến mạch máu não, hoặc bị parkinson, gặp khó khăn vận động, tôi nghĩ chắc chắn là công trình nghiên cứu này có thể cải thiện khả năng vận động, đi lại. » 

Our approach to treating disease is, in many ways, narrow and rooted in the past. Is it time for a new paradigm? This hour, TED speakers share their visions for new ways to understand medicine. Guests include cancer physician and writer Siddhartha Mukherjee, surgeon and writer Atul Gawande, neurosurgeon Jocelyne Bloch, and internist Joseph Ravenell.

La neurochirurgienne Jocelyne Bloch possède une très grande expérience en matière de traitement des atteintes au cerveau, des AVC jusqu'au traumatismes dus aux accidents de voiture et ne connaît ainsi que trop bien l'incapacité du cerveau à se réparer lui-même. Cependant, elle aurait découvert avec ses collègues la clé de la réparation neuronale : les cellules double-cortines actives. Similaires aux cellules souches, elles sont extrêmement adaptables, et quand elles sont extraites du cerveau, mises en culture puis réinjectées dans une partie lésée d'un même cerveau, elles peuvent aider à le réparer et à le reconstruire. « Avec un peu d'aide, nous dit Bloch, le cerveau peut se réparer lui-même. »

Tratando de tudo, de AVCs a traumas decorrentes de acidentes de carro, a neurocirurgiã Jocelyne Bloch sabe da inabilidade do cérebro para reparar a si mesmo completamente. Mas agora, ela sugere, pode ser que ela e seus colegas tenham encontrado o segredo para a reparação neural: células de cortisona duplas positivas. Semelhantes às células-tronco, elas são extremamente adaptáveis e, quando extraídas do cérebro, colocadas em cultura e então reinjetadas numa área lesionada desse mesmo cérebro, elas podem ajudar a repará-lo e a reconstruí-lo. "Com um pouco de ajuda", diz Bloch, "o cérebro pode conseguir ajudar a si próprio.".

뇌졸증부터 차 사고 외상 치료를 통해 외과 의사 조슬린 브로치는 뇌가 스스로 회복하는데 무능하다는 것을 너무나 잘 압니다. 그러나 지금 그녀와 동료가 신경 회복에 대한 열쇠를 발견했을 지도 모른다고 제안합니다. 더블코틴-양성 세포. 줄기세포와 마찬가지로, 그 세포는 아주 적응을 잘 하고, 뇌에서 추출해서 배양한 뒤 같은 뇌의 손상부위에 주입하면 뇌를 회복하고 재생하는데 도움을 줍니다. "약간의 도움으로" "뇌는 스스로 도울 수 있습니다."라고 브로치가 말합니다.

Habiendo tratado de todo, desde derrames cerebrales a accidentes automovilísticos, la neurocirujana Jocelyne Bloch conoce la incapacidad del cerebro para la autoreparación. Pero ahora, junto con sus colegas, podrían haber descubierto la clave de la reparación neuronal: las células positivas doblecorticales. Estas células, similares a las células madre, se adaptan sumamente bien y cuando se extraen, cultivan y reimplantan en la misma zona lesionada del cerebro pueden contribuir a su regeneración. "Con un poco de ayuda," dice Bloch, "el cerebro podría autorepararse."

Through treating everything from strokes to car accident traumas, neurosurgeon Jocelyne Bloch knows the brain's inability to repair itself all too well. But now, she suggests, she and her colleagues may have found the key to neural repair: Doublecortin-positive cells. Similar to stem cells, they are extremely adaptable and, when extracted from a brain, cultured and then re-injected in a lesioned area of the same brain, they can help repair and rebuild it. "With a little help," Bloch says, "the brain may be able to help itself."

Aus ihren Behandlungen von Schlaganfällen und Traumata nach Verkehrsunfällen weiß Neurochirurgin Jocelyne Bloch nur allzu gut um die mangelnde Selbstheilungskraft des Gehirns. Aber jetzt könnten sie und ihre Kollegen den Schlüssel zur neuronalen Selbstheilung gefunden haben: Doublecortin-positive Zellen. Ähnlich wie Stammzellen sind sie sehr anpassungsfähig. Wenn man sie dem Gehirn entnimmt, kultiviert und dann in einem verletzten Bereich desselben Gehirns reimplantiert, können sie den Wiederaufbau und den Heilungsprozess hilfreich unterstützen. "Mit ein wenig Hilfe," sagt Bloch, "könnte das Gehirn in der Lage sein, sich selbst zu heilen."