Podcasts about G12

⚡Sigue a Somos Uno en:INSTAGRAM - http://Instagram.com/somosunogoTIKTOK - https://t.co/BrcoTnKnkS?amp=1SPOTIFY - http://G12.es/s1spotifyEN VIVO ⌚SÁBADOS 4 Y 6PM (Hora Colombia

We have before us a fresh opportunity to play our part in the re-evangelism of our own nation and other nations. Each one of us, each individual, couple, family, and church, can make a big difference for God in this generation and for the good of generations to come. This is a time for us to unblock the wells and discover once more the life-giving waters of the Holy Spirit, which have so often flowed in revival power in this country. Wherever you are in the world, you have an important role to play in re-evangelising your nation.   We read in Matthew 9:35-38 and Matthew 10:1 how Jesus did this, and the example we are to follow: “Jesus went through all the towns and villages, teaching in their synagogues, proclaiming the good news of the kingdom and healing every disease and sickness. 36 When he saw the crowds, he had compassion on them, because they were harassed and helpless, like sheep without a shepherd. 37 Then he said to his disciples, “The harvest is plentiful but the workers are few. 38 Ask the Lord of the harvest, therefore, to send out workers into his harvest field. 1 Jesus called his twelve disciples to him and gave them authority to drive out impure spirits and to heal every disease and sickness.”   1. Focus on the mission of Jesus (Matthew 9:35; Acts 1:8) 2. Receive the vision of Jesus for the multitudes (Matthew 9:36; John 4:35) 3. Have the love of Jesus for lost and hurting people (Matthew 9:36) 4. Pray for more workers as Jesus instructed (Matthew 9:38) 5. Build a team of 12 as Jesus modelled (Matthew 10:1)  Apply    1. Focus on the mission of Jesus. The mission that Jesus has called us to is simply massive. Jesus has commanded us to make disciples of all nations. God sent His only Son Jesus on a mission to save the whole world from Satan, sin and all the destructive powers of darkness. The sheer scope of our mission requires us to think bigger and beyond what our minds usually process. Our mission in life is to win the world for Jesus. And to conquer globally we must follow the example of Jesus being focussed locally. Jesus went about His mission in a very strategic way by starting in His home region of Galilee (Matthew 9:35). He was very specific and very diligent in going from town to town and even from village to village. Later Jesus gave specific directions on focussing on different locations for the spread of the gospel throughout the world (Acts 1:8). The mission then requires that the Christian gospel is spread systematically from area to area. We must be sure that we are focussed not simply on running our churches but on reaching our communities with a very clear strategy. Like Jesus, we must have a big mission to reach ‘all the towns and villages' in the areas that God has called us to. We have to all play our part in spreading the gospel of the kingdom to all peoples in all nations starting in all the towns and villages where we are.    2. Receive the vision of Jesus for the multitudes (Matthew 9:36). Jesus didn't just see individuals; He saw vast numbers of people in great need, and He wanted His disciples also to have their eyes open to seeing the multitudes (John 4:35). How much do we really notice people? God wants to open our eyes to see the multitudes all around us and to believe as Abraham believed that we can have limitless spiritual offspring. Ministry begins with vision. We need a vision of what is possible for large numbers of people to be brought to Christ in our churches and our nations. We must perceive it and believe it before we can receive it.    3. Have the love of Jesus for lost and hurting people (Matthew 9:36 MSG). Love is what Christianity is all about. Jesus came because God so loved the world. Love is what drew the multitudes to Jesus. They knew that, unlike the hard-hearted, self-seeking religious leaders, Jesus truly cared for them. They could see His compassion, especially for the outcasts and despised. And it was because of Jesus' love for lost sinners that He suffered and bled and died. It is this sacrificial, unconditional, patient, kind and enduring love that we must have in our hearts if we are going to keep our children and grandchildren in the church. So many children and young people have wandered away, often with great bitterness in their hearts, because they have experienced the law but never the love of God. It's this love and compassion in our hearts, our actions and in our eyes that will draw people to Christ and establish them in their faith. So how do we get this love? Only by asking for the Holy Spirit to come and change us. For us to see people turn to God, we must have this love.    4. Pray for more workers as Jesus instructed (Matthew 9:38). The mission is so big and the challenge so great that many more people must be involved in sharing the good news of Christ and His kingdom. If we are serious about re-evangelising our nations, we must seek to mobilise ALL the people of God to share their faith. The so-called professionals or paid ministers cannot do it on their own. We must really pray that great numbers of Christians who are busy doing their jobs and caring for their families, will share their faith wherever they are and integrate disciple-making into their lives. It is a matter of great urgency to pray for more workers if we want to see our nations turn around.    5. Build a team of 12 as Jesus modelled. After calling for prayer for more workers, Jesus formed a team of disciples (Matthew 10:1). These 12 were ordinary people and far from perfect. One on the list of the chosen 12 betrayed Jesus and had to be replaced, and the other 11 all ran away at one point. But they were to become the foundation of the church, because Jesus never gave up on His simple plan to focus on gathering, training and releasing the few to reach the many. Today the G12 vision is a re-emergence of a biblical vision for making and multiplying disciples by taking them through every stage from new birth to maturity, to become leaders and multipliers themselves. The 12 can develop 12 who can have 12 who can have 12, and so on. We just need to do this right and continually. And as we follow the example of Jesus in doing these 5 steps, we will see another grassroots transformational Christian movement in our nations and in our day and generation. 

We have before us a fresh opportunity to play our part in the re-evangelism of our own nation and other nations. Each one of us, each individual, couple, family, and church, can make a big difference for God in this generation and for the good of generations to come. This is a time for us to unblock the wells and discover once more the life-giving waters of the Holy Spirit, which have so often flowed in revival power in this country. Wherever you are in the world, you have an important role to play in re-evangelising your nation.   We read in Matthew 9:35-38 and Matthew 10:1 how Jesus did this, and the example we are to follow: “Jesus went through all the towns and villages, teaching in their synagogues, proclaiming the good news of the kingdom and healing every disease and sickness. 36 When he saw the crowds, he had compassion on them, because they were harassed and helpless, like sheep without a shepherd. 37 Then he said to his disciples, “The harvest is plentiful but the workers are few. 38 Ask the Lord of the harvest, therefore, to send out workers into his harvest field. 1 Jesus called his twelve disciples to him and gave them authority to drive out impure spirits and to heal every disease and sickness.”   1. Focus on the mission of Jesus (Matthew 9:35; Acts 1:8) 2. Receive the vision of Jesus for the multitudes (Matthew 9:36; John 4:35) 3. Have the love of Jesus for lost and hurting people (Matthew 9:36) 4. Pray for more workers as Jesus instructed (Matthew 9:38) 5. Build a team of 12 as Jesus modelled (Matthew 10:1)  Apply    1. Focus on the mission of Jesus. The mission that Jesus has called us to is simply massive. Jesus has commanded us to make disciples of all nations. God sent His only Son Jesus on a mission to save the whole world from Satan, sin and all the destructive powers of darkness. The sheer scope of our mission requires us to think bigger and beyond what our minds usually process. Our mission in life is to win the world for Jesus. And to conquer globally we must follow the example of Jesus being focussed locally. Jesus went about His mission in a very strategic way by starting in His home region of Galilee (Matthew 9:35). He was very specific and very diligent in going from town to town and even from village to village. Later Jesus gave specific directions on focussing on different locations for the spread of the gospel throughout the world (Acts 1:8). The mission then requires that the Christian gospel is spread systematically from area to area. We must be sure that we are focussed not simply on running our churches but on reaching our communities with a very clear strategy. Like Jesus, we must have a big mission to reach ‘all the towns and villages' in the areas that God has called us to. We have to all play our part in spreading the gospel of the kingdom to all peoples in all nations starting in all the towns and villages where we are.    2. Receive the vision of Jesus for the multitudes (Matthew 9:36). Jesus didn't just see individuals; He saw vast numbers of people in great need, and He wanted His disciples also to have their eyes open to seeing the multitudes (John 4:35). How much do we really notice people? God wants to open our eyes to see the multitudes all around us and to believe as Abraham believed that we can have limitless spiritual offspring. Ministry begins with vision. We need a vision of what is possible for large numbers of people to be brought to Christ in our churches and our nations. We must perceive it and believe it before we can receive it.    3. Have the love of Jesus for lost and hurting people (Matthew 9:36 MSG). Love is what Christianity is all about. Jesus came because God so loved the world. Love is what drew the multitudes to Jesus. They knew that, unlike the hard-hearted, self-seeking religious leaders, Jesus truly cared for them. They could see His compassion, especially for the outcasts and despised. And it was because of Jesus' love for lost sinners that He suffered and bled and died. It is this sacrificial, unconditional, patient, kind and enduring love that we must have in our hearts if we are going to keep our children and grandchildren in the church. So many children and young people have wandered away, often with great bitterness in their hearts, because they have experienced the law but never the love of God. It's this love and compassion in our hearts, our actions and in our eyes that will draw people to Christ and establish them in their faith. So how do we get this love? Only by asking for the Holy Spirit to come and change us. For us to see people turn to God, we must have this love.    4. Pray for more workers as Jesus instructed (Matthew 9:38). The mission is so big and the challenge so great that many more people must be involved in sharing the good news of Christ and His kingdom. If we are serious about re-evangelising our nations, we must seek to mobilise ALL the people of God to share their faith. The so-called professionals or paid ministers cannot do it on their own. We must really pray that great numbers of Christians who are busy doing their jobs and caring for their families, will share their faith wherever they are and integrate disciple-making into their lives. It is a matter of great urgency to pray for more workers if we want to see our nations turn around.    5. Build a team of 12 as Jesus modelled. After calling for prayer for more workers, Jesus formed a team of disciples (Matthew 10:1). These 12 were ordinary people and far from perfect. One on the list of the chosen 12 betrayed Jesus and had to be replaced, and the other 11 all ran away at one point. But they were to become the foundation of the church, because Jesus never gave up on His simple plan to focus on gathering, training and releasing the few to reach the many. Today the G12 vision is a re-emergence of a biblical vision for making and multiplying disciples by taking them through every stage from new birth to maturity, to become leaders and multipliers themselves. The 12 can develop 12 who can have 12 who can have 12, and so on. We just need to do this right and continually. And as we follow the example of Jesus in doing these 5 steps, we will see another grassroots transformational Christian movement in our nations and in our day and generation. 

Churches across the UK have come together this weekend for the G12 UK Conference 2024: The Great Harvest. This week's online service is the preach that Pastor Wes shared at the 2023 conference:  Today we have before us a fresh opportunity to play our part in the re-evangelism of this nation and other nations. Each one of us, each individual, couple, family, and church, can make a big difference for God in this generation and for the good of generations to come.    This is a time for us to unblock the wells and discover once more the life-giving waters of the Holy Spirit, which have so often flowed in revival power in this country. Each of these 5 keys are themes of the G12 Vision and have been central to the growth of one of the world's largest churches in Bogota, Colombia.    We see these keys in Matthew 9:35-37 and Matthew 10:1: Jesus went through all the towns and villages, teaching in their synagogues, proclaiming the good news of the kingdom and healing every disease and sickness. 36 When he saw the crowds, he had compassion on them, because they were harassed and helpless, like sheep without a shepherd. 37 Then he said to his disciples, “The harvest is plentiful but the workers are few. 38 Ask the Lord of the harvest, therefore, to send out workers into his harvest field. 1 Jesus called his twelve disciples to him and gave them authority to drive out impure spirits and to heal every disease and sickness.    1. Focus on the mission of Jesus (Matthew 9:35; Acts 1:8) 2. Receive the Vision of Jesus for the multitudes (Matthew 9:36; John 4:35) 3. Have the love of Jesus for lost and hurting people (Matthew 9:36) 4. Pray for more workers as Jesus instructed (Matthew 9:38) 5. Build a team of 12 as Jesus modelled (Matthew 10:1)   Apply    1. Focus on the mission of Jesus. The mission that Jesus has called us to is simply massive. Jesus has commanded us to make disciples of all nations. God sent His only Son Jesus on a mission to save the whole world from Satan, sin and all the destructive powers of darkness. The sheer scope of our mission requires us to think bigger and beyond what our minds usually process. Our mission in life is to win the world for Jesus. And to conquer globally we must follow the example of Jesus being focussed locally. Jesus went about His mission in a very strategic way by starting in His home region of Galilee (Matthew 9:35). He was very specific and very diligent in going from town to town and even from village to village. Later Jesus gave specific directions on focussing on different locations for the spread of the gospel throughout the world (Acts 1:8). The mission then requires that the Christian gospel is spread systematically from area to area. We must be sure that we are focussed not simply on running our churches but on reaching our communities with a very clear strategy. Like Jesus must have a big mission to reach ‘all the towns and villages' in the areas that God has called us to. We have to all play our part in spreading the gospel of the kingdom to all peoples in all nations starting in all the towns and villages where we are.    2. Receive the Vision of Jesus for the multitudes (Matthew 9:36). Jesus didn't just see individuals; He saw vast numbers of people in great need, and He wanted His disciples also to have their eyes open to seeing the multitudes (John 4:35). How much do we really notice people? God wants to open our eyes to see the multitudes all around us and to believe as Abraham believed that we can have limitless spiritual offspring. Ministry begins with vision. We need a vision of what is possible for large numbers of people to be brought to Christ in our churches and our nations. We have to perceive it and believe it before we can receive it.   3. Have the love of Jesus for lost and hurting people (Matthew 9:36 MSG). Love is what Christianity is all about. Jesus came because God so loved the world. Love is what drew the multitudes to Jesus. They knew that, unlike the hard-hearted, self-seeking religious leaders, Jesus truly cared for them. They could see His compassion especially for those who were outcasts and despised. And it was love for lost sinners that Jesus suffered and bled and died. It is this sacrificial, unconditional, patient, kind and enduring love that we must have in our hearts if we are going to keep our children and grandchildren in the church. So many children and young people have wandered away, often with great bitterness in their hearts, because they have experienced the law but never the love of God. And it's this love and compassion in our hearts and in our actions and in our eyes that will draw people to Christ and establish them in their faith. The G12 vision is not some clinical method but an expression of the heart of God and a powerful means of bringing God's love to masses of people and to train them as disciples. So how do we get this love? Only by asking for the Holy Spirit to come and change us. For us to see people turn to God, we must have this love.   4. Pray for more workers as Jesus instructed (Matthew 9:38). The mission is so big and the challenge is so great that we must have many more people involved in sharing the good news of Christ and His kingdom. If we are serious about re-evangelising this nation, we must seek to mobilise ALL the people of God to share their faith. The so-called professionals or paid ministers can never cope on their own. There are about 30,000 clergy of all types in the UK and more than 80,000 registered witches and fortune tellers. Today we must really pray that great numbers of Christians who are busy doing their jobs and caring for their families, will share their faith wherever they are and integrate disciple-making into their lives. It is a matter of great urgency to pray for more workers if we want to see this nation turn around.   5. Build a team of 12 as Jesus modelled. After calling for prayer for more workers, Jesus formed a team of disciples (Matthew 10:1). These 12 were ordinary people and far from perfect. One on the list of the chosen betrayed Jesus and had to be replaced, and the other 11 all ran away at one point. But they were to become the foundation of the church, because Jesus never gave up on His simple plan to focus on gathering, training and releasing the few to reach many. Today the G12 Vision is a re-emergence of a biblical vision for making and multiplying disciples by taking them through every stage from new birth to maturity to become leaders and multipliers themselves. The 12 can develop 12 who can have 12 who can have 12, and so on. We just need to do this right and continually. And if we will take hold of these five keys, we will see another grassroots transformational Christian movement in this country and in our day and generation. Are you up for it?! 

Churches across the UK have come together this weekend for the G12 UK Conference 2024: The Great Harvest. This week's online service is the preach that Pastor Wes shared at the 2023 conference:  Today we have before us a fresh opportunity to play our part in the re-evangelism of this nation and other nations. Each one of us, each individual, couple, family, and church, can make a big difference for God in this generation and for the good of generations to come.    This is a time for us to unblock the wells and discover once more the life-giving waters of the Holy Spirit, which have so often flowed in revival power in this country. Each of these 5 keys are themes of the G12 Vision and have been central to the growth of one of the world's largest churches in Bogota, Colombia.    We see these keys in Matthew 9:35-37 and Matthew 10:1: Jesus went through all the towns and villages, teaching in their synagogues, proclaiming the good news of the kingdom and healing every disease and sickness. 36 When he saw the crowds, he had compassion on them, because they were harassed and helpless, like sheep without a shepherd. 37 Then he said to his disciples, “The harvest is plentiful but the workers are few. 38 Ask the Lord of the harvest, therefore, to send out workers into his harvest field. 1 Jesus called his twelve disciples to him and gave them authority to drive out impure spirits and to heal every disease and sickness.    1. Focus on the mission of Jesus (Matthew 9:35; Acts 1:8) 2. Receive the Vision of Jesus for the multitudes (Matthew 9:36; John 4:35) 3. Have the love of Jesus for lost and hurting people (Matthew 9:36) 4. Pray for more workers as Jesus instructed (Matthew 9:38) 5. Build a team of 12 as Jesus modelled (Matthew 10:1)   Apply    1. Focus on the mission of Jesus. The mission that Jesus has called us to is simply massive. Jesus has commanded us to make disciples of all nations. God sent His only Son Jesus on a mission to save the whole world from Satan, sin and all the destructive powers of darkness. The sheer scope of our mission requires us to think bigger and beyond what our minds usually process. Our mission in life is to win the world for Jesus. And to conquer globally we must follow the example of Jesus being focussed locally. Jesus went about His mission in a very strategic way by starting in His home region of Galilee (Matthew 9:35). He was very specific and very diligent in going from town to town and even from village to village. Later Jesus gave specific directions on focussing on different locations for the spread of the gospel throughout the world (Acts 1:8). The mission then requires that the Christian gospel is spread systematically from area to area. We must be sure that we are focussed not simply on running our churches but on reaching our communities with a very clear strategy. Like Jesus must have a big mission to reach ‘all the towns and villages' in the areas that God has called us to. We have to all play our part in spreading the gospel of the kingdom to all peoples in all nations starting in all the towns and villages where we are.    2. Receive the Vision of Jesus for the multitudes (Matthew 9:36). Jesus didn't just see individuals; He saw vast numbers of people in great need, and He wanted His disciples also to have their eyes open to seeing the multitudes (John 4:35). How much do we really notice people? God wants to open our eyes to see the multitudes all around us and to believe as Abraham believed that we can have limitless spiritual offspring. Ministry begins with vision. We need a vision of what is possible for large numbers of people to be brought to Christ in our churches and our nations. We have to perceive it and believe it before we can receive it.   3. Have the love of Jesus for lost and hurting people (Matthew 9:36 MSG). Love is what Christianity is all about. Jesus came because God so loved the world. Love is what drew the multitudes to Jesus. They knew that, unlike the hard-hearted, self-seeking religious leaders, Jesus truly cared for them. They could see His compassion especially for those who were outcasts and despised. And it was love for lost sinners that Jesus suffered and bled and died. It is this sacrificial, unconditional, patient, kind and enduring love that we must have in our hearts if we are going to keep our children and grandchildren in the church. So many children and young people have wandered away, often with great bitterness in their hearts, because they have experienced the law but never the love of God. And it's this love and compassion in our hearts and in our actions and in our eyes that will draw people to Christ and establish them in their faith. The G12 vision is not some clinical method but an expression of the heart of God and a powerful means of bringing God's love to masses of people and to train them as disciples. So how do we get this love? Only by asking for the Holy Spirit to come and change us. For us to see people turn to God, we must have this love.   4. Pray for more workers as Jesus instructed (Matthew 9:38). The mission is so big and the challenge is so great that we must have many more people involved in sharing the good news of Christ and His kingdom. If we are serious about re-evangelising this nation, we must seek to mobilise ALL the people of God to share their faith. The so-called professionals or paid ministers can never cope on their own. There are about 30,000 clergy of all types in the UK and more than 80,000 registered witches and fortune tellers. Today we must really pray that great numbers of Christians who are busy doing their jobs and caring for their families, will share their faith wherever they are and integrate disciple-making into their lives. It is a matter of great urgency to pray for more workers if we want to see this nation turn around.   5. Build a team of 12 as Jesus modelled. After calling for prayer for more workers, Jesus formed a team of disciples (Matthew 10:1). These 12 were ordinary people and far from perfect. One on the list of the chosen betrayed Jesus and had to be replaced, and the other 11 all ran away at one point. But they were to become the foundation of the church, because Jesus never gave up on His simple plan to focus on gathering, training and releasing the few to reach many. Today the G12 Vision is a re-emergence of a biblical vision for making and multiplying disciples by taking them through every stage from new birth to maturity to become leaders and multipliers themselves. The 12 can develop 12 who can have 12 who can have 12, and so on. We just need to do this right and continually. And if we will take hold of these five keys, we will see another grassroots transformational Christian movement in this country and in our day and generation. Are you up for it?! 

How do you design learning in your classroom/school?  Imagine inviting student input on everything from the way the timetable is organized, to the design of learning experiences, even to how they are assessed and evaluated.  That's the kind of voice and choice The Green School Bali provides its learners. And their learners are empowered as a result.  In this illuminating podcast episode, Head of the Upper School/Learning Dialogist/Writer/Podcaster Dr. Benjamin Freud and I unpack: Practical methods for inviting student voice/choice into the design of learning How to include more community voices, including parents, local community stakeholders and the bio-collective  How to organize curriculum around students' interests, sustainability, and other topics and projects they hope to explore    The kind of mindset required to welcome continual feedback, iteration, and collective co-design and ways to adopt it    Connect with Dr. Benjamin Freud: LinkedIN, Twitter/X Learn more about Coconut Thinking (Ben's Podcast): https://coconut-thinking.com/benjamin-freud/  Learn more about the Green School, Bali: https://www.greenschool.org/ Take the Free 12 Shifts for Student-Centered Environments Scorecard: www.transformschool.com/12shiftsscorecard  Pre-Order the 12 Shifts Book (coming in August): www.transformschool.com/whereistheteacher  Dr. Benjamin Freud's Bio: Dr. Benjamin Freud is an educator, learning dialogist, writer, and podcaster. He is the co-founder of Coconut Thinking, an advisory that helps and supports educators nurture learning ecosystems grounded in relationships that contribute to the thriving of the bio-collective—any living thing that has an interest in the healthfulness of the planet. He designs learning experiences that de-center the human, moving us toward a more ecological civilization. He is also the Head of Upper School at The Green School Bali.  Before Green School, Benjamin was the Whole School Director of Learning at Prem Tinsulanonda International School in Chiang Mai, Thailand. He focused on the “lived” curriculum. He considered ways to develop a culture of active learning, where disciplinary boundaries start to disappear, and learners engage in meaningful projects that have an impact on themselves, others, and the world…all of this preferably taking place outside. He was responsible for teacher professional development, introducing innovative pedagogical practices, and taught classes from G4 to G12. Before Prem, Benjamin was at Misk Schools, the most prestigious and high profile school in Saudi Arabia. Along with being responsible for all day-to-day operations and leadership in the Boys' School, Benjamin developed a unique curriculum to nurture and develop creativity, competencies, and entrepreneurial spirit in learners. He was responsible for designing authentic and Problem-Based Learning experiences across the school and for developing and implementing Personal Learning Pathways for each learner, to understand their academic and personal needs so that they can best thrive.  

En entrevista para MVS Noticias con Manuel López San Martín, Cynthia López Castro, de la coalición “Fuerza y Corazón por México”; Renata Turrent, coalición “Sigamos Haciendo Historia”, y Juan Zavala Gutiérrez, de Movimiento Ciudadano participaron en una "Mesa de análisis y debate" sobre los resultados de la elección presidencial. Para iniciar la conversación, Renata Turrent se dijo agradecida con la participación de los ciudadanos que confiaron en el proyecto de Claudia Sheinbaum, quien aseguró no defraudará a la nación.  "Claudia Sheinbaum tiene tres cosas en la mesa, en primer lugar, cumplir las propuestas de campaña, esa protección de los principios de la 4T (recuperación de lo público y ampliación de derechos) y la inclusión, ejercer ese poder con responsabilidad, igualdad y respeto", declaró.   En contraste, Cynthia López, se dijo muy preocupada por el hecho de que Morena tendrá todo el poder en las cámaras y llamó irresponsable al pueblo de México por su elección.    "Morena tendrá que ser muy responsable. Sin embargo creo que la oposición hizo un gran trabajo de Taboada, de mucha alcaldías, lo que vemos es que sí hay oposición, que sí estamos organizados, lo que sí debemos hacer es cambiar los lentes y ver otras carencias...Aprender lo que se tenga que aprender, mejorar como oposición", mencionó.   En tanto, para Juan Zavala, la elección de este 2 de junio significó mucho para Movimiento Ciudadano, ya que lograron demostrar que pueden ser una alternativa política para el país.   "Creo que sí vamos a entrar en una etapa de reflexión, por qué votaron así, competimos en adversidad de circunstancias, teníamos menos recursos, competir contra dos coaliciones de tres partidos, en medio de todo esto y muchos poderes fácticos, sacamos una votación de 6 millones de mexicanos. Nos llevamos el voto joven que sentía que no había una alternativa y hoy es Jorge Álvarez Máynez", declaró.    ¿Qué hay del Plan C de Morena?  Renata Turrent siguiendo con la conversación, recriminó a Cynthia López por calificar de "irresponsable" la decisión de los ciudadanos y aseguró que pese a lo que se dice, Morena no desaparecerá los poderes ni organismos como mucho se ha dicho.  "Me parece que es precisamente el discursos por el cual están en donde quedaron, llamarle a la gente comprados, llamarle a la gente que son manipulados, es ofender a la gente... Morena fue muy claro en que quería, para quería el poder, para que era el plan C...Nosotros queremos que siga el poder judicial. Nadie va a desaparecer ningún poder judicial. Necesitamos a todos y a todos... Se busca reformar", explicó.  En respuesta, Cynthia López aseguró que la estrategia de Morena será desaparecer el Poder Judicial y otras instancias como el INE o el INAI.   ¿Qué sigue después de las elecciones para las fuerzas políticas del país?  Para terminar, Cynthia López lamentó el triunfo de Morena y su mayoría e hizo un llamado a la próxima administración. "Morena ganó la elección, tiene mayoría en las cámaras, les pido como ciudadana no sean irresponsables, tenemos miedo", respondió Cynthia López.  En tanto, Renata Turrent se dijo muy feliz con la nueva era que está por comenzar en el país ahora que entre en operaciones el mandato de la presidenta Claudia Sheinbaum, quien muy seguramente se apegará a cumplir sus promesas de campaña.  "Hay programas específicos para jóvenes, para que no acaban en las calles; ampliación de derechos para personas repartidoras, la creación de más de un millón de viviendas, infraestructura, transición energética, neoshoring... Es muy emocionante tener una mujer presidenta, que una mujer gobierne un G12", expresó.  Por su parte, Juan Zavala se comprometió a seguir trabajando por el país hasta consolidarse como una verdadera alternativa.   See omnystudio.com/listener for privacy information.

URL: https://www.tropicalpunkrecords.com/2024/05/16/el-poste-148-con-tres-pasos-take-off-subversivoz-g12-sofia-serpiente-ultimo-nietos-y-control/ En este episodio 148 de El Poste del Neo Travel Cast tenemos música de Take Off, Tres Pasos, G12, Sofia Serpiente, Último Nietos y Control además de las últimas noticias del punk, ska y hardcore en Colombia. Ya están todos los episodios en tu plataforma favorita. Por favor sigan enviando sus noticias, conciertos, lanzamientos y sobre todo, comentarios. Escucha este y más episodios en Neo Travel Cast. MÚSICA Take Off (Cali) - Shoganai Tres Pasos (Bogota) - Visajoso SubVersivoz (Madrid) - Sub Versos G12 (Bogota) - Ya No Me Trabo, No Sofia Serpiente, Último Nietos (Cali) - Cuántos Días Iguales Control (Medellín) - Sentenciados ATENCIÓN: Si tu banda de punk, ska o hardcore (en cualquiera de sus subgéneros) va a lanzar música, contáctanos y la estrenamos en este programa. Lo mismo noticias y conciertos. Todo de toda Colombia entra en este show. POR FAVOR: Darle Like, comentar, repostear, decirle a tus amigos, conocidos, etc. En este espacio cabemos todos y esperamos que todos lo hagan suyo para dar a conocer el trabajo de tantos compositores, músicos y personas que se expresan con esta música. Síguenos en Instagram: https://www.instagram.com/tropicalpunkrec/

Save money. Make money. Save time. These are the three big reasons most businesses buy a product, a service or even hire a person. Sometimes hidden behind those big three is productivity. Teams is being adopted by organizations, and Momentum not only wanted to help their clients do Teams, but to do Teams better. Too realize productivity. In this podcast Rick Garcia of Momentum shares with us his journey, as a founder of G12, and now, through Momentum's acquisition of G12, a part of Momentum's quest to help companies get the most from Teams. “Our job really is to communicate with the enterprises, to communicate with businesses, share with them what Microsoft Teams is capable of. We've got a plethora of UC platforms as well, but Microsoft Teams right now, if you look at it from a productivity perspective, cost perspective, and just feature tool set, this is quite impressive.” Visit https://gomomentum.com/

Falamos de família, obediência, relacionamento, ministério, visão G12, profissão e entre tantas coisas ainda queríamos mais!!! Um episódio premium diríamos e que com certeza tem algum ensinamento pra sua vida.

In this week's bonus episode, Bill Fotsch, a business consultant, explains why he thinks much of the effort that he and many others have put into creating employee engagement over the past three decades has been wasted effort—well intentioned, but wasted. The fact is, Fotsch says, employees today are no more engaged than they were some 30 years ago when the concept of employee engagement first gained currency. So what's the answer? Fotsch has come to the conclusion that it's something he calls “economic engagement,” which happens to be the name of his consulting business. What exactly is economic engagement? He says it's getting employees to focus on serving customers, and doing so profitably. He says it's not so much about sharing financials with employees but about getting employees to understand the strategies and actions that really drive a business's profitability. Fotsch is so convinced that he's cracked the code that he's gone beyond mere consulting and has been buying stakes in businesses so he can implement his ideas and prove his concept. So far, he says, it's working.Show Notes:See how you score on an economic-engagement benchmark survey.Here's Gallup's G12 employee-engagement survey.Bill Fotsch co-authored an article that argues economic engagement is a logical successor to open book management.

Have you ever found yourself nervous to choose a new church, worried that you may end up in a spiritually abusive environment? Have you ever felt something was off in the church you were currently attending, but didn't know how to be sure? In this month's episode, we'll be discussing these questions and more, as we dive into our discussion regarding red flags of an unhealthy church. Our special guest for this month's panel discussion is Dulce Johnson. Dulce, along with her husband and children, left a G12 church that taught a prosperity gospel, Word of Faith, the "little gods" doctrine, and was very similar to hyper fundamentalism with its authoritarianism, elitism, and tribalism. Dulce shares her story of finding the true gospel, as well as what she learned along the way about recognizing red flags and green flags when evaluating churches. Joining her in this discussion are Andrew, Natalie, and for the first time on the Not Ashamed podcast, Natalie's husband, Cole. You can find Dulce with her handle "honestmessylife" on Instagram, Facebook, and TikTok. The "Not Ashamed" podcast is brought to you by Berean Holiness. You can find more of our content at: BereanHoliness.com "For I am not ashamed of the gospel, for it is the power of God for salvation to everyone who believes..." —Romans 1:16

Síganos en PazConDios en YouTube para ver todos los videos que publicamos. En este programa, contesto las preguntas que me mandan a la luz de la Palabra de Dios. Puedes enviarme tus preguntas a preguntas@pazcondios.com Las preguntas que contestamos en este video son: 1. ¿Tengo que dejar mi iglesia y congregarme con mi esposo? 2. ¿Cómo puedo saber si mi novia es la que Dios ha escogido para mi? 3. Mi pastor no toma en cuanta a ninguno de los líderes. ¿Debo dejar a mi iglesia? 4. ¿Un Cristiano puede jugar la lotería o juegos de apostar? 5. ¿Deben los pastores discipular a los otros líderes en su iglesia? 6. ¿Puede un Cristiano pedir que Dios le una esposa? 7. ¿Puede un Cristiano tratar de ganar a una muchacha que está en una relación con otro hombre? 8. Mi pastor es psicólogo, ¿debería buscar otra iglesia? 9. ¿Qué significa Tito 1:11? 10. ¿Puedo orar sólo con la mente, sin cerrar los ojos? 11. ¿Es bíblico el movimiento G12 y su encuentros? 12. ¿Por qué pide Dios que personas divorciadas no se vuelvan a casar? 13. ¿Puedo andar de novios con la hija de mi prima? 14. ¿Puede un pastor cobrar para dar estudios bíblicos? 15. ¿Puede Dios restaurar matrimonios si uno o el otro no quiere? 16. ¿Puedo llevar un expareja alcohólico a la iglesia conmigo?

acompáñenos en esta nueva aventura, con us G12 de los podcast

Kenny and the mayor exchange new UFO theories. GL'ers find new dangers in the proposed voting law which would pre-register teens to vote. Check out the names to rename Patrick Henry High School. DFL'er from Chanhassen tells farmers that solar is the new corn. Heard On The Show:Hartman goal in 2nd OT gives Wild 3-2 win over Stars in G12 dead, homicide investigation underway in Dayton's Bluff neighborhoodElk River's Marcus Cinema to permanently close TuesdayRussian judge denies appeal of Wall Street Journal reporter Learn more about your ad choices. Visit podcastchoices.com/adchoicesSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

[Александр Кленингер] Пасха наша, Христос, заклан за нас.

[Александр Кленингер] Пасха наша, Христос, заклан за нас.

[Александр Кленингер] В этой теме мы поговорим о всей важности понимания того, что говорили семь громов на Небесах.

[Александр Кленингер] В этой теме мы поговорим о всей важности понимания того, что говорили семь громов на Небесах.

[Андреас Калаш]

[Андреас Калаш]

JCO PO author Dr. Mohamed Salem shares insights into his JCO PO article, “Landscape of KRASG12C, Associated Genomic Alterations, and Interrelation With Immuno-Oncology Biomarkers in KRAS-Mutated Cancers” and the article's findings of a large-scale, pan-cancer genomic characterization of KRASG12C. Host Dr. Rafeh Naqash and Dr. Salem discuss KRASG12C mutation, KRASG12C -mutated tumors and comutation with STK11 and KEAP1. Click here to read the article!   TRANSCRIPT Dr. Abdul Rafeh Naqash:  Hello and welcome to JCO Precision Oncology Conversations, where we bring you engaging conversations with authors of clinically relevant and highly significant JCO PO articles. I'm your host, Dr. Abdul Rafeh Naqash, Social Media Editor for JCO Precision Oncology and assistant professor of Medical Oncology at the OU Stephenson Cancer Center.  Today I'm thrilled to be joined by Dr. Mohamed Salem, Gastrointestinal Medical Oncologist, and Research Director at the Levine Cancer Institute in Charlotte, North Carolina. Dr. Salem is the lead author of the JCO Precision Oncology article ‘Landscape of KRASG12C, Associated Genomic Alterations, and Interrelation With Immuno-Oncology Biomarkers in KRAS-Mutated Cancers'.  Our guest's disclosures will be linked in the transcript.  Dr. Salem, welcome to our podcast, and thank you for joining us today. Dr. Mohamed Salem: Thank you for having me. A pleasure and honor. Dr. Abdul Rafeh Naqash: For the sake of this podcast, we'll be referring to each other using our first names. So thank you for coming on to our podcast and discussing this very interesting paper. And one of the reasons why we decided to incorporate this is because, as you very well know, KRAS is one of the most common altered genes in cancer, and I'm pretty confident and sure that oncologists, whether it's academic oncologists or community oncologists, have treated patients in different settings having tumors that harbor KRAS alterations. So give us a little bit of a background on where KRAS alterations stand currently and where is drug development in the space of KRAS to give our listeners some idea of why we're interested in this gene. Dr. Mohamed Salem: Sure, thanks again for having me. And as you mentioned, KRAS mutation happens to be, I think, by far the most common oncogenic mutation we see in oncology and solid tumors. The problem with KRAS is that, for a long, long time, there was very much nothing we could do about it; it was, in fact, called an undruggable target. Until recently, we started to realize this might not be true, and, in fact, we start to see successful efforts trying to target KRAS mutation. Currently, there are several KRAS inhibitors. I think it started with G12C. I personally don't think there was anything specific about G12C, but it just happened to be one of the first targets that we were able to approach. And the initial result from using anti-G12C therapy that was published in the New England Journal of Medicine, I think, a year ago now, showed this is feasible and perhaps effective. Dr. Abdul Rafeh Naqash: Thank you so much, Dr. Salem, for that explanation. And being a Phase I trialist, I personally have seen a lot of exciting combination-based approaches in the setting of KRAS-altered tumors, especially KRASG12C.  Now, specifically delving into your paper, given the extensive length and breadth of data that you've covered here, could you tell us a little bit about why you decided to use KRAS as an interesting topic for your study and the kind of data set that you chose to explore this question?  Dr. Mohamed Salem: What happened once we started to realize how important it is to figure out which KRAS mutation we're dealing with because, at least in colorectal cancer, it's a very common mutation, almost like 40-50% of patients with colorectal cancer tumors carry KRAS mutation. Until very recently, we really didn't pay close attention to which variant it is. Is it KRAS G12D, 13, or G12C? And so on and so forth. And the reason we didn't really pay much attention to that is because there was nothing to do about it; whether the patient has this or that variant was really nothing therapeutically wise it really didn't have an impact. But once we started to realize now there is a therapeutic option and, in fact, now there is a change in the way we think about KRAS mutation, there is a proof of concept that we actually can target KRAS mutation, we started to pay closer attention to this.  And I think this was a paradigm shift in our thinking. So for patients who have KRAS mutation, now we have data showing that KRASG12C is something we can target, whether with single agent or with combination therapy. But it was a new era for us because most of us realized it's not going to stop there. It's not going to be just G12C; I think G12C is the tip of the iceberg, and likely the science is going to go forward, try to target the other variants. So one of the obvious questions was what are the other variants and how commonly those exist, and which tumor types also carry those variants. Because as we were talking before the recording for Phase I, now it is not like one approach fits all; it started to kind of like focus on either molecularly driven or disease-type approaches. And it was very important for us to try to figure out, okay, which tumor type carries the most KRAS variants and, within that tumor, which variants are the most common. And this is what we're trying to answer in this paper.  Dr. Abdul Rafeh Naqash: Thank you so much, Mohamed. I looked at your data set that you had access to, very large data set of around 79,000 tumor samples and close to 14,000 KRAS mutated tumors. Could you tell us a little more about this data set and how you started with looking at the distribution of KRAS across different tumors, and what were the kind of interesting results that you came across as far as KRAS distribution is concerned? Dr. Mohamed Salem: It's very obvious to all of us now that the field is moving from one size fits all to a targeted approach or treatment target approach. And this is very important and very interesting because usually, when we do that, we achieve better outcomes and lesser toxicity. But the problem that comes with this is that none of us, as a single, even two centers, will have enough data to ask and answer questions. And when you are talking about something like MSI-high or BRAF or KRAS, usually it becomes very challenging for one single institution, doesn't matter how big they are, to try to answer either prevalent or therapeutic approaches. Because of that, most of us now start to understand that cooperation is very important across centers and also across nations.  So, like as you see here in this paper, there was a global cooperation between investigators in the U.S. and in Europe and Austria, and other countries. And what we did as a group we worked with one of the third-party profiling companies. Our group tried to answer what is the prevalence, just a very simple question, what is the prevalence of KRAS mutation, and what is the prevalence of each variant type in each tumor? And none of us could have answered that question on their own. Because of that, we actually collaborated with one of the third-party companies that do next-generation sequencing for tumors, and we were able to collaborate with them to have access to that database and answer some of those questions.  Dr. Abdul Rafeh Naqash: Excellent. As everybody knows, NGS is a standard of care testing that oncologists do, especially for advanced settings, to identify driver alterations or therapeutic interventions that may be relevant for patients. So in this data set, it seems you had access to NGS data, tumor mutational burden, and PD-L1 data for these tumor types. Could you tell us about the differences in the distribution for KRAS and the KRAS subtypes that you identified in this data set? Dr. Mohamed Salem: Sure. So, as you mentioned, we looked actually at almost 79,000 tumor samples that underwent next-generation sequencing by our collaborator. And it appears that about 17% of the tumors or so had some kind of KRAS mutation. And then, after that, we start to see G12C when we start looking at each variant. G12C were about 11%, 12%, and about 88% of the remaining KRAS mutant tumors harbored some different kind of KRAS mutation.  The next question was, in general, in all tumors, what was the most common KRAS variant seen? I think it mimicked what was already out there. It appears that G12D happened to be perhaps the most frequent mutation seen in KRAS mutation tumors, followed by G12V, followed by G12C, and then G12/13, and then others. What was very interesting, actually, an observation we saw, is that we were able to realize the distribution of KRAS variants varies according to the tumor subtype. So, for example, in pancreatic cancer, we could see patients who had G12R KRAS mutation variants. This was not seen commonly in other tumors. And the reason that's important is because maybe that will be something in pancreatic cancer tumors that will be worth looking at and do therapeutic approach there. But also, I'm sure you're already dealing with this in your clinic quite often. It was interesting, obviously, that non-small cell lung cancer was the most common organ that actually carries G12C, followed by colorectal cancer; followed by a very interesting actual observation that was very interesting for us to see was in appendiceal cancer. As you know, appendiceal cancer is not a common disease; it's a relatively rare disease. And we were surprised to see some of them actually have G12C mutation. And again, the reason that's important is that it just opens the door for possible therapeutic options and in context of clinical trials. Dr. Abdul Rafeh Naqash: Excellent. Definitely, the advantage of having such a rich data set like you did enabled you to look into some of these unique distributions across rare tumors, which makes it very interesting.  Now, one thing that I realized in the paper is that these tumors of unknown origin, where you identified or your group identified that they had a certain percentage of KRAS alterations, suggesting maybe their tumor of origin is perhaps lung or upper diaphragm, which could have therapeutic implications. Could you tell us a little more about this? Dr. Mohamed Salem: Yeah, this was another very interesting observation we saw because it is not uncommon for us in the clinic, we get like a cancer biopsy, but we cannot tell where it's coming from. And there are multiple ongoing efforts to try to identify that for the obvious reasons. But it was very interesting when we looked at those groups that when you had cancer adenocarcinoma but of no identified origin, it was the fourth common tumor that we see G12C. I think if you can just make the assumption - I don't think we have proved that - but since lung cancer was the most common tumor that exhibited G12C mutation, and now we have tumors of unknown origin also, many of them exhibit G12C mutation, we thought this could be a lung primary. As you know, there are also now a few platforms trying to identify the tumor origin based on the agent sequencing, but we didn't try to associate it with that. Dr. Abdul Rafeh Naqash: Thank you for that explanation. Now, one of the other things I observed is you tried to delve into smoking status, very interestingly, and how that correlated with KRAS alterations. And as we know, lung cancer, obviously there is a strong predilection in patients who are smokers, but irrespective of smoking, there can be other alterations that drive lung cancer. But interestingly, in your paper, you identified a unique correlation between smoking and G12C and also found out something on those lines in colorectal cancer, which, to my understanding, has not been described before. What is your understanding of why that happens? What could be the mutational events that lead to something like that, and how could that be potentially therapeutically exploited? Dr. Mohamed Salem: I think this was one of the very interesting findings we observed. And you are right; just because the nature of lung cancer, we know many of patients are either active smokers or former smokers. So it was not a surprise for us to see that there is some kind of association with smoking status and lung cancer. But to your point, what was really surprising and, in a way, interesting for us to see, actually, that association for patients with colorectal cancer. Smoking actually happens to be one of the risk factors, like in colon cancer, but obviously not as high as lung cancer. But when we looked at the data, demographic, and clinical features, it was obvious actually that current smoking status, whether a current smoker or prior smoker, had an association with G12C. And also, with gender as well, females tend to have more G12C, or G12C mutation was more likely to be seen in females than males. So the fact that we were able to identify the smoking status and gender as more likely to harbor G12C mutation was interesting.  I have to tell you, the reviewer, when we submitted the paper for review, the reviewer came back and asked us, did this happen just because you had too many lung cancer, and most lung cancer patients smoke, that's why you're seeing that association? And we went back and looked at the data again and spoke with our biostat team in the study, and we were able to actually run the analysis and show that, no, it is not just because of the enrichment; it's actually a real association between the smoking status and G12C. It's very interesting to see, at least in colorectal cancer, it's following the same trend in lung cancer. Dr. Abdul Rafeh Naqash: Right. And one of the other things I remember when I was reading through your paper and smoking status, I remembered this paper that was published in Science Magazine 2016, looking at how mutational burden changes in patients that have a history of smoking. But when you connect the dots here, interestingly, it seems like, especially in lung cancer, from what you guys have described here, is that the smoking status impacts what kind of KRAS alteration is present. But at the same time, you didn't see a tumor mutational burden that was significantly higher in G12C, mutated non-small cell lung cancer, where you would expect a lot of these G12Cs to be related to smoking. But on the other hand, the tumor mutational burden was not necessarily increased. And I understand you may not have an explanation for that through the data that you've published on, but that was kind of an interesting observation that I had. I don't know if you have any specific comments on that. Dr. Mohamed Salem: No, it's absolutely correct. What we thought is that we should see that because the obvious rationale is just cited, but it wasn't. And until today, we're actually trying to figure out why the disconnect because you have people who smoke usually you expect like PD-L1 is positive, you expect higher tumor burden, but it didn't show at least a statistically significant correlation.  Dr. Abdul Rafeh Naqash: Thank you. And I guess it's notable to mention that you did have some interesting correlations for tumor mutational burden overall, and with PD-L1. Could you tell us about that for different KRAS genetic alterations?  Dr. Mohamed Salem: There were few papers published before by our colleagues trying also to understand the correlation between G12C mutation and immunostatus or immune microenvironment and some biomarkers. And I think, at least to my understanding, there was not one consensus. I think it was different findings to some degree. So, in general, when we actually looked at the entire cohort, regardless of the tumor type, it appears that tumors that carry G12C mutation also happened to have higher PD-L1 expression. What was very interesting was that once we started to look at different tumor types, this was not seen across all tumors. So some tumors did actually carry that, and some other tumor types didn't show that correlation. And to be honest with you, I'm still, until today, I'm not sure why. Is this just a function of number, or actually there is more tumor biology that reflects that? I have to say my own feeling, and that's something we need to study further, is that I think it is tumor biology. One thing was also very interesting to us from the clinical side. You have G12C mutation in lung, and you have G12C mutation in colorectal, and in the New England Phase I study, you could see very clearly that targeted G12C is more effective in the lung compared to colorectal. It's the same target, the same drug, yet the response is different once you start to have two different tumor types. So that just got me to think there must be something with the tumor type and microenvironment of the tumor and also associated co-mutations and other factors that impact that.  Dr. Abdul Rafeh Naqash: I couldn't agree with you more, and I totally have seen that in some of the work that has been published or data that I've been part of where different tumor biology, the tumor microenvironments, even sites of metastasis make a difference in how a certain mutation behaves. So definitely something that needs further validation with perhaps proteomic and transcriptomic data to understand functional characterization of the downstream consequences for some of these mutations. And you pointed out co-mutation status. That's an ever-emerging question for some of the potentially druggable alterations, whether combination approaches targeting some other co-occurring common co-mutation would have more benefit. Could you tell us about some of the unique, interesting commutations that you identified in your cohort that were more common in certain KRAS subtypes? Dr. Mohamed Salem: Sure. I think that's also something we try to look at for the reason I just mentioned. We know that tumor origin and tumor type influence response and sensitivity to therapy. I think the best example we have, at least in colorectal cancer, is the BRAF mutation. When we saw the BRAF inhibitor having very nice response rate and control of BRAF mutant melanoma in colorectal cancer, we saw that it's going to be the same thing, the same drug, the same target, same thing's going to happen. And obviously, it was not the case. And this was a lesson for all of us to understand. Even if it is the same target, even if it's the same drug, tumor origin matters, and that's likely because of the associated co-mutations that will influence the pathway of the tumor and perhaps either the sensitivity to the drug or maybe resistance to the drug.  So it was very important for us to look also at the associated co-mutations. And I think one of the KEAP1, and perhaps you will comment on this more than me, but the KEAP1 gene was likely to be mutated in those tumors who have G12C mutation than others. Another one was STK11. And there were a few other ones, it depends on which tumor type, but KEAP1 was a very interesting finding for us too. Because as you're aware, it's important, at least in lung cancer, and maybe will impact therapeutic approach too. Dr. Abdul Rafeh Naqash: You're definitely right. It is important in lung cancer, and there's data that has shown both the STK11 and KEAP1 tumors have inferior outcomes to checkpoint inhibitors and are partly involved in metabolic reprogramming of the tumors. So there's definitely emerging targets that are trying to see if combination approaches in STK11 mutant lung cancer will demonstrate some level of benefit. But I think the co-mutation status would potentially have some sort of impact. But again, functional studies that help us understand what are the downstream consequences of one mutation versus another need to be further performed to get a better understanding of this space.   But I think this is definitely interesting work and very interesting results. Hopefully, our listeners will feel the same and maybe even try to go through the paper to understand some of the other additional results that you have published as part of this extensive paper.  We thank you on behalf of JCO Precision Oncology for submitting your work to JCO Precision Oncology, and hopefully, you'll consider us for further subsequent work in this space. Thank you so much for being with us today. Dr. Mohamed Salem:  No, thank you for having me, and actually, on behalf of my co-authors, I also wanted to thank JCO Precision Oncology for their interest in our paper. And, of course, for the reviewers, because there was no doubt they actually made our paper a much better one. So thank you for having me today, thank you for the entire team. Dr. Abdul Rafeh Naqash:  Reviewers definitely remain the people hidden behind the scenes who help in getting work refined and eventually published. So thank you again. And thank you for listening to JCO Precision Oncology Conversations. Don't forget to give us a rating or a review, and be sure to subscribe, so you never miss an episode. You can find all ASCO shows at asco.org/podcasts   The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experiences, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement. Guest Bio Mohamed E. Salem, MD, is Research Director, Associate Professor of Medicine, and Gastrointestinal Medical Oncologist in the Department of Solid Tumor Oncology at the Levine Cancer Institute.  Guest Disclosures (See also: Landscape of KRASG12C, Associated Genomic Alterations, and Interrelation With Immuno-Oncology Biomarkers in KRAS-Mutated Cancers) Mohamed Salem: Consulting or Advisory Role: Taiho Pharmaceutical, Exelixis, Bristol-Myers Squibb, QED Therapeutics, Novartis, Pfizer, Daiichi Sankyo/Astra Zeneca, Merck  Speakers' Bureau: Taiho Pharmaceutical, Daiichi Sankyo/Astra Zeneca, BMS, Merck, Pfizer 

月底是主持人Kong的期末考週，但是比賽還是要看，節目一樣要錄。但是怕他晚上睡覺腦子都是籃球，就盡量講少一點（？   本週請到了二次回鍋的苦情教練，南港國小的教頭 泰霖，還有也是在台北基層籃球 育成高中的教練 justin ，陪我們先從打完預賽的HBL談起。   本週比賽，領航猿終於在鋼鐵人主場拿下本季首勝，而一直處於混沌狀態的鋼鐵人到底是遇到什麼問題？在週二的平日賽事，鳳山圖書館內卻在最後打出不一樣的內容，但一樣的結局。   新北國王的開季連勝紀錄終結在自己的主場，究竟夢想家使出什麼樣的法寶，讓一路連勝的國王處處受挫。就算夢想家被單換掉一個洋將與老吳手比愛心的幫助之下，國王怎麼還是大比分落敗？   更多胡亂吹促進度與猿迷笑容都在本集霹靂鍵盤節目！  

En este episodio, los muchachos deciden traer a la mesa de El Tribunal un tema que ha dado la vuelta al mundo del fútbol en los últimos días, como pocas veces se ha visto. Conversaron junto a Yelena Hazim (Directora de Desarrollo de FEDOFUTBOL), Jorge Allen Bauger (Director Ejecutivo LDF), Francisco Lapouble (Abogado – Especialista Derecho Deportivo) y Avelino Cuadra (Comunicador de Fútbol) donde valoraron la idea propuesta por el G12 o los Malvados 12. Mynor Valverde también hizo llegar su opinión sobre todo lo sucedido el pasado domingo 18 de abril de 2021. ¿Estaba destinada a morir? ¿Es la única forma de “salvar” al fútbol? ¿Fue una desconsideración con el mundo del fútbol? ¡Escucha este episodio imperdible y ten tu propia opinión sobre la Superliga, no dejes que otros lo hagan por ti!

El año pasado leí un libro que me impactó mucho. Sin embargo, cuando recién vi el libro por primera vez cuestioné si debería leerlo o no. Sin embargo, me decidí hacerlo y fue uno de los libros mas importantes que leí el año pasado. Decidí por fin compartirlo en este episodio. Así es que quiero que escuches muy bien todo lo que voy a compartir y que lo puedas aplicar. Sé que puedes tener algunas prevenciones al escuchar el titulo, pero te aseguro que no es nada de lo que estas pensando. Norman Vincent Peale nació en Bowersville, Ohio, Estados Unidos el 31 de mayo de 1898 y falleció el 24 de diciembre de 1993 en Pawling, Nueva York. Se educó en la Universidad de Boston, en la Universidad Wesleyana de Ohio y en Boston University School of Theology. Peale puso sus habilidades a trabajar por muchos años. El Poder del Pensamiento Positivo, fue publicado en 1952 y ha vendido cerca de 20 millones de copias y ha sido impreso en 41 lenguajes diferentes.

“Cuando dejas de esperar que las personas sean perfectas, puedes amarlos por quienes son” -Donald MillerA veces es más fácil esperar lo peor de otras personas que esperar lo mejor, pero cuando tu haces el esperar lo mejor de los demás, el asumir una intención positiva en cada cosa que hacen o que dicen, esto te libera, te hace una persona mas alegre, te ayuda a conquistar temores profundamente arraigados. 

En diversas ocasiones nos encontramos con la realidad de ver que las circunstancias o algunas personas, o aún nosotros mismos decimos que algo es imposible, o que no podemos o que nunca lo vamos a lograr. ¿Qué hacer entonces cuando tenemos un deseo y aparentemente el el mundo dice no? La confianza debe estar puesta en Dios, pero también debemos tener un cambio de mentalidad, principalmente es usar nuestra desventaja como una ventaja. En este episodio hablamos de la importancia de perseverar a pesar de los obstáculos y de reflexionar en nuestra motivación para alcanzar lo que queremos. Si la motivación es correcta tendremos la suficiente fuerza y fe para ejecutar nuestro plan. 

En momentos de incertidumbre el temor habla constantemente. ¿Qué podemos hacer para pasar del temor a la fe? Gran parte del resultado esta en aprender a alimentar la fe más que alimentar el temor. En el episodio de hoy comparto algunas cosas prácticas que puedes hacer para subir al nivel de la fe y de la esperanza. Cuando hay esperanza puedes ver posibilidades y oportunidades en medio de cualquier obstáculo o desafío.Espero que puedas aplicar esta sencilla enseñanza. Comparte en tus redes sociales y se una persona que lleva fe y esperanza en este momento en donde muchos lo necesitan. 

Todos enfrentamos momentos de crisis o momentos inesperados. Nos podemos quedar paralizados o podemos movernos. En momentos difíciles, los lideres se hacen más visibles pues son aquellos que afrontan la situación y generan soluciones. En el momento de crisis lo que es verdaderamente importante sale a flote. Escribí hace un tiempo que “ninguna persona en sus ultimas horas de vida piensa o dice: “ojalá hubiera estado más tiempo en la oficina”. En momentos cómo estos conocemos lo que verdaderamente importa. El mundo esta cambiando rápidamente y esta necesitando de personas que estén dispuestas a liderar en momentos difíciles con un corazón hacia los demás, que piensen claramente y sean creativos y que tomen decisiones en fe. Ese es el tipo de líder que debes ser. Es momento de tener fe y así podemos convertir este desafío en nuestra mayor oportunidad para crecer. 

En este episodio hablamos un poco de relaciones, cómo hemos podido entendernos mejor desde nuestra experiencia después de 10 años de casados y también hablamos acerca de que liderar es servir. Muchas personas han hablado, escrito y comentado acerca de lo que es liderar pero la verdad disfruté mucho esta conversación con mi esposa. Hemos aprendido que el líder no comienza con la pregunta ¿qué puedes hacer por mí? sino todo lo contrario; un verdadero líder constantemente le pregunta a los que están a su alrededor ¿qué puedo hacer por ti? Toda persona que aspira a tener un liderazgo correcto debe estar dispuesto a ayudar a otros a cumplir sus metas y a alcanzar su propósito y como fruto de esto las personas que están a su alrededor estarán comprometidas para ayudarlo a alcanzar lo que quiere. El liderazgo de servicio es probablemente la solución a los complejos problemas de hoy en día y puede ser el mayor aliado de cualquier persona que quiera encontrar el propósito por el cual esta en esta tierra. En este episodio junto a mi esposa hablamos de lo que significa el liderazgo de servicio y algunos principios prácticos que puedes aplicar para que añadas valor a cada persona que te rodea.

En este episodio Johan Manjarrez, vocalista de Generación 12 nos habla de su proceso para encontrar el propósito perfecto que Dios diseño para cada líder. Definitivamente encontrar el propósito es una de las cosas mas gratificantes. A través de sus experiencias y testimonios Johan cuenta como desde niño sintió que era diferente y a pesar de muchas dificultades pudo tener un encuentro que cambió su vida. Cuando entregamos nuestra vida a Dios, el nos lleva a ser mejores personas y mejores líderes. 

Un nuevo año es una oportunidad para cambiar. Estos 3 principios te ayudarán y motivarán a tomar decisiones para tener tu mejor año hasta ahora. En el comienzo de cada año comenzamos con buenos deseos, pero a medida que el tiempo pasa nos quedamos simplemente con los deseos pero no logramos materializarlos en cambios sustanciales, con estos principios podrás tomar decisiones firmes para que te conviertas en la persona que Dios siempre ha querido y diseño que fueras. 

¡Estamos en el 2020! Es el momento perfecto de adquirir nuevas disciplinas y cambiar nuestros hábitos. Personalmente considero que una de las disciplinas más importantes que una persona puede tener es el enfoque. El enfoque va mucho más allá de establecer una meta o tener un deseo. El enfoque es lo que te lleva a establecer prioridades personales, a hacer sacrificios cuando se requiere, a planear y a evaluar para que cualquier meta que establezcas se pueda cumplir. Este año he determinado que será el año del enfoque y mi deseo es motivarte y ayudarte a que te puedas enfocar para así lograr lo que siempre has deseado lograr o aún puedas llegar a donde nunca habías imaginado posible.  «Ten muy presente que tu enfoque determina tu realidad».” Daniel Goleman, Focus: Desarrollar la atención para alcanzar la excelenciaEl enfoque es el secreto para que puedas hacer lo que siempre has soñado hacer con la calidad que nunca habías pensado tener, en menos del tiempo que habías pensado que iba a tomar.

¿Cuántas veces has puesto metas que no pudiste cumplir? A todos tratamos es escribir o por lo menos pensar en algunas metas o propósitos para el proximo año con el deseo de no quedarnos a mitad de camino. A todos nos gusta cumplir metas y alcanzar cosas, es parte de la naturaleza del ser humano, es por esto que es muy importante aprender a establecer metas. En el episodio de hoy comparto la sigla SMART para establecer metas, nos da algunas características importantes que cada una de nuestras metas debe tener para que sean más efectivas. (Smart Goals/Metas inteligentes)S - EspecíficaM - MedibleA - AlcanzableR - RealistaT - Tiempo 

Cada año que pasa aprendemos lecciones valiosas, algunas de ellas inolvidables. En este episodio tuve el deseo de compartir las 10 lecciones mas importantes del 2019. 

Kike Pavon es un cantautor y compositor español quien ha logrado llevar un mensaje diferente a cientos de miles de personas en diferentes países del mundo. Lo caracteriza su capacidad de conectar con el público y con las personas que lo rodean. Hoy en día vivimos en un mundo que gira al rededor de las redes sociales, especialmente en el tema musical y artístico pueden ser una herramienta clave para desarrollarte, sin embargo Kike tomó una decisión que en su momento iba en contra de la lógica, pero después del tiempo ha visto el fruto de esta sabia decisión que lo llevó a crecer en su auto disciplina y a aprender a disfrutar de cada momento sin estar pensando en las opiniones o comentarios de las personas. En este episodio Kike nos habla de esa decisión y nos motiva a vivir vidas con disciplina y con determinación pues es la única manera de ver los resultados que Dios espera que tengamos. 

Hoy se celebra en los Estados Unidos el día de acción de gracias. Es una celebración especial en la cual las familias se reúnen a simplemente agradecer a Dios por todas las cosas que se han recibido en el año. Aunque se celebra desde 1789, en 1863 Abraham Lincoln proclamó que este dia seria el “día de acción de Gracias y Alabanza al buen Padre que vive en los cielos”. La gratitud es una de las herramientas mas poderosas que tenemos y que en algunas ocasiones subestimamos. En este episodio serás retado a pensar en las cosas por las cuales estás agradecido y serás motivado a hacer algo al respecto.

Todos deseamos aprender a maximizar nuestro tiempo. Todo ser humano enfrenta la realidad de saber que nuestro tiempo en esta tierra es limitado, es por esto que debemos aprender a manejar uno de los recursos más importantes que Dios ha puesto en nuestras manos. El pensamiento común es que entre más cosas yo haga seré mas productivo, pero la verdad es que es todo lo contrario. Analizamos como el objetivo no es estar ocupado sino ser productivo y como a través de estos 3 sencillos consejos podemos hacer que nuestro tiempo se maximize y así alcanzar mas trabajando y haciendo menos. Si quieres comenzar algo nuevo, aprender algo nuevo o ver mas resultados en lo que haces este episodio puede darte las bases para comenzar a cambiar como controlas tu tiempo o mejor como te controlas a ti mismo. 

Sara Castellanos es una líder que se determinó desde una temprana edad vivir para cumplir el propósito de Dios. En este episodio ella nos comparte algunos de los principios que le han ayudado a construir su liderazgo, a encontrar su propósito y a tomar decisiones importantes. Sara enseña que es cuando nadie nos esta viendo que crecemos y aprendemos para poder después enseñar a otros, también nos da su punto de vista de una pregunta que recibo muy a menudo en el Podcast y es "¿Cómo escucho la voz de Dios?" 

En el último episodio de esta serie acerca de las 12 Características de los Líderes Inolvidables cerramos hablando de las ultimas cuatro cualidades de aquellos líderes que sobresalen. Confianza y respeto, trabajan en equipo, celebran los éxitos y tienen las prioridades correctas. No te puedes perder este episodio que esta lleno de cosas prácticas que puedes aplicar en todo lo que tu haces y en el desarrollo de tu liderazgo. 

Hay líderes que tienen la capacidad de dejar una marca en aquellas personas que los siguen y se convierte en una marca inolvidable que perdura a través del tiempo. En esta serie acerca de las 12 características de los Lideres Inolvidables estudiamos aquellas cosas que diferencian a los lideres extraordinarios y que son fundamentales para poder desarrollar un liderazgo efectivo. La semana pasada vimos las primeras cuatro que fueron: Vision, Influencia, Ejemplo (o los líderes lo hacen primero) y Confianza en el equipo. En el episodio de hoy vemos 4 más: Enseñar a otros, Ser un excelente comunicador, Empoderar a otros y por último conexión. 

Ya son 12 episodios en el podcast La Academia! Gracias a todos por su apoyo y por acompañarme en esta aventura. En este episodio y en los siguientes dos vamos a hablar de las 12 características que tienen los líderes inolvidables. Hay líderes que tienen la capacidad de dejar una marca en aquellas personas que los siguen y se convierte en una marca inolvidable que perdura a través del tiempo. Las cuatro características de hoy son: Vision, Influencia, Ejemplo (o los líderes lo hacen primero) y Confianza en el equipo.

¿Cuántas veces has intentado cambiar algo a principio de año? ¿Cuántas veces has tratado de cambiar algún hábito y nos has podido? Constantemente intentamos implementar una rutina de ejercicios, comer mejor, ahorrar más, pagar nuestras deudas, tomar mas agua, tener mas tiempo con la familia entre otros. Pero estos simplemente quedan en deseos. En este episodio hablamos un poco de cómo cambiar de manera efectiva aquellos hábitos que siempre hemos querido cambiar recordando las palabras del apóstol Pablo "todo lo puedo en Cristo que me fortalece.

Esta es parte de la conferencia que compartí hace una de semana en un evento la cual titulé: ¡Solo hazlo! Creo que todos deseamos crecer y hay momentos decisivos en donde tenemos que poner la fe en acción y simplemente hacerlo. En esta conferencia comparto principios sencillos pero que pueden cambiar tu vida si los pones en práctica. La verdad me identifico mucho con este mensaje, pues mas allá de una enseñanza es un estilo de vida que Dios me ha enseñado y me ha encargado de compartirlo con otros. 

Una de las episodios más comentados ha sido el de cómo salir del estancamiento, muchos líderes me han escrito acerca de este tema, pues quieren aprender más al respecto. Esta es la segunda parte de “que hacer cuando te sientes estancado” y compartir un principio que se que te ayudará mucho para salir del estancamiento y entrar en el crecimiento. Cuando removemos las creencias limitantes podemos comenzar a caminar y a actuar por fe. 

En Enero 20, 2017, con mas de un billón de personas viendo en vivo, el pastor Samuel Rodriguez se convirtió en el primer latino cristiano en participar de una ceremonia de inauguración presidencial. Recientemente fue el productor ejecutivo de la exitosa película 'Breakthrough' en conjunto con 20th Century Fox y Franklin Entertainment. En este episodio junto al pastor Samuel Rodriguez hablamos de lo que significa ser líder, como vivir una vida ejemplar y que pasa cuando le dices no a una oportunidad buena, para poder decirle si a una oportunidad mejor que viene de parte de Dios. "Tu eres lo que tú toleras" es uno de los principios por los cuales Samuel Rodriguez se basa para tener una vida de ejemplo y que inspire a otros. Determinate a levantarte y cumplir el propósito de Dios. 

¿Has experimentado el temor? Hace poco asistí a una convención y quede impactado con el testimonio de una mujer llamada Carey Lohrenz. En las primeras paginas de su libro Fearless Leadership, que se traduciría algo como “Liderazgo sin temor” cuenta una experiencia que ilustra muy bien lo que significa enfrentar el temor. Neil Armstrong dijo: "No puede haber un gran logro sin ningún riesgo." En este episodio exploramos algunos aspectos importantes y las 7 verdades acerca de vencer el temor. 

Las cosas que nos hacen sentir frustrados o quebrantados pueden convertirse en la mayor oportunidad para hacer algo verdaderamente importante. En este episodio junto a mi esposa Lorena Castellanos vemos lo que puede y debe suceder cada vez que nos encontramos frente a una situación que nos aflige o nos preocupa. Martin Luther King dijo: “Nuestra vida empieza a terminar el día en que nos quedamos callados acerca de las cosas que verdaderamente importan”. Cuando nos decidimos a hacer algo al respecto de algo que nos molesta o nos incomoda cosas increíbles pueden suceder, pero los pasos que des son determinantes. En este episodio aprende como ser un líder que convierte efectivamente la preocupación en una visión. 

En diferentes ocasiones de nuestra vida nos sentimos estancados. Llegamos a sentirnos frustrados porque a pesar de las muchas cosas que hagamos no vemos el resultado que queremos. En este episodio, mi esposa Lorena Castellanos comparte tres cosas prácticas para que salgas del estancamiento y para que puedas romper el techo que te esta impidiendo crecer. Estoy convencido que cuando el líder mejora todo a su alrededor cambia. 

Henry Ford dijo: “No tienes que tener una posición para ser un un líder”. Hoy más que nunca el mundo necesita líderes. En el lugar en el que estés eres puedes convertirte en un líder. Y no solo en un líder sino el mejor líder que puedes ser. En este episodio descubrirás las tres preguntas que todo seguidor le hace a su líder, estas nos sirven para evaluarnos constantemente y se convierten en una guía para ser efectivos en nuestra misión de influir en otros.