Podcasts about G13

Play Episode Listen Later Dec 24, 2024 81:28

Our Hallmark Heroes - the conflicted Holly Ringer, her big city boyfriend Johnny Evans, her small town friend Patricia "Trish" Kaek and her former flame Cole Mississippi - made quite the scene at the Chestnut Ball. Johnny abandoned Holly to dance with Hailey Barris when she promised him a film role, Trish outed Johnny as a scumbag to the entire town, and Cole confessed his love to the devastated Holly (who ran away). Can these heroes escape the trap set by Axel Stormborn, or will Hallmark AND AMERICA be lost forever to Polaris Rome, international terrorist for hire!? Enjoying Hallmark: Never Stop Blowing Up?- Consider becoming a Patron of Dumb-Dumbs & Dice for as little as $1 a month and gain access to a ton of extra BTS fun (https://www.patreon.com/dumbdumbdice)- Buy merch on our website (https://dumbdumbdice.com/)- Watch us on YouTube (https://youtube.com/@dumbdumbdice)- Follow us on Instagram (https://instagram.com/dumbdumbdice)- Follow us on Facebook (https://facebook.com/dumbdumbdice) Our Cast:Game Master - Ryan LaPlanteHolly Ringer - Del BorovicCole Mississippi - Guy BradfordPatricia Kaek - Pam SparrowJohnny Evans - Josh HalbotOur Crew:Editor - Ryan LaPlanteSound Editor - Laura HamstraArtwork by the brilliant Del Borovic- Website & Portfolio (https://delborovic.com/)- X/Twitter (https://twitter.com/deltastic)

Hallmark Never Stop Blowing Up - Episode 12 - The Chestnut Ball

Play Episode Listen Later Dec 23, 2024 51:48

Our Hallmark Heroes - the conflicted Holly Ringer, her big city boyfriend Johnny Evans, her small town friend Patricia "Trish" Kaek and her former flame Cole Mississippi - recovered at Grandma's house, where Johnny proposed to Holly and she accepted. Cole had a breakdown before Trish consoled him and he returned to his farm, while the rest of the team chose outfits for the ball. Can these heroes join forces to triumph at the Chestnut Ball, or will their interpersonal conflicts allow Polaris Rome, international terrorist for hire, to take over Hallmark (and America) forever!? Enjoying Hallmark: Never Stop Blowing Up?- Consider becoming a Patron of Dumb-Dumbs & Dice for as little as $1 a month and gain access to a ton of extra BTS fun (https://www.patreon.com/dumbdumbdice)- Buy merch on our website (https://dumbdumbdice.com/)- Watch us on YouTube (https://youtube.com/@dumbdumbdice)- Follow us on Instagram (https://instagram.com/dumbdumbdice)- Follow us on Facebook (https://facebook.com/dumbdumbdice) Our Cast:Game Master - Ryan LaPlanteHolly Ringer - Del BorovicCole Mississippi - Guy BradfordPatricia Kaek - Pam SparrowJohnny Evans - Josh HalbotOur Crew:Editor - Ryan LaPlanteSound Editor - Laura HamstraArtwork by the brilliant Del Borovic- Website & Portfolio (https://delborovic.com/)- X/Twitter (https://twitter.com/deltastic)

Hallmark Never Stop Blowing Up - Episode 11 - The Proposal

Play Episode Listen Later Dec 20, 2024 50:02

Our Hallmark Heroes - the conflicted Holly Ringer, her big city boyfriend Johnny Evans, her small town friend Patricia "Trish" Kaek and her former flame Cole Mississippi - destroyed a nuclear submarine, saving America's springwater supply! Johnny Evans distracted the enemy by getting captured, Holly and Trish deactivated a nuclear bomb, and Cole caused an explosion that took out the sub and the warehouse surrounding it! Can these heroes recover from their injuries quickly enough to become Chestnut King and Queen, or will Polaris Rome, international terrorist for hire, complete his takeover of the heart of America!? Enjoying Hallmark: Never Stop Blowing Up?- Consider becoming a Patron of Dumb-Dumbs & Dice for as little as $1 a month and gain access to a ton of extra BTS fun (https://www.patreon.com/dumbdumbdice)- Buy merch on our website (https://dumbdumbdice.com/)- Watch us on YouTube (https://youtube.com/@dumbdumbdice)- Follow us on Instagram (https://instagram.com/dumbdumbdice)- Follow us on Facebook (https://facebook.com/dumbdumbdice) Our Cast:Game Master - Ryan LaPlanteHolly Ringer - Del BorovicCole Mississippi - Guy BradfordPatricia Kaek - Pam SparrowJohnny Evans - Josh HalbotOur Crew:Editor - Ryan LaPlanteSound Editor - Laura HamstraArtwork by the brilliant Del Borovic- Website & Portfolio (https://delborovic.com/)- X/Twitter (https://twitter.com/deltastic)

Hallmark Never Stop Blowing Up - Episode 10 - Captain Lightning vs. Admiral Blaze

Play Episode Listen Later Dec 19, 2024 51:34

Our Hallmark Heroes - the conflicted Holly Ringer, her big city boyfriend Johnny Evans, her small town friend Patricia "Trish" Kaek and her former flame Cole Mississippi - have minutes before a nuclear submarine disappears into Lake Springwater! Johnny and Holly managed to win the Chestnut Hockey game 14-0 while Trish and Cole stole Devil Diver uniforms for the whole team! Can these heroes infiltrate the private army of Captain Jack Lightning, or will Polaris Rome, international terrorist for hire, irradiate America's supply of bottled water!?Enjoying Hallmark: Never Stop Blowing Up?- Consider becoming a Patron of Dumb-Dumbs & Dice for as little as $1 a month and gain access to a ton of extra BTS fun (https://www.patreon.com/dumbdumbdice)- Buy merch on our website (https://dumbdumbdice.com/)- Watch us on YouTube (https://youtube.com/@dumbdumbdice)- Follow us on Instagram (https://instagram.com/dumbdumbdice)- Follow us on Facebook (https://facebook.com/dumbdumbdice) Our Cast:Game Master - Ryan LaPlanteHolly Ringer - Del BorovicCole Mississippi - Guy BradfordPatricia Kaek - Pam SparrowJohnny Evans - Josh HalbotOur Crew:Editor - Ryan LaPlanteSound Editor - Laura HamstraArtwork by the brilliant Del Borovic- Website & Portfolio (https://delborovic.com/)- X/Twitter (https://twitter.com/deltastic)

Hallmark Never Stop Blowing Up - Episode 9 - Chestnut Hockey & A Nuclear Submarine

Play Episode Listen Later Dec 18, 2024 48:22

Our Hallmark Heroes - the conflicted Holly Ringer, her big city boyfriend Johnny Evans, her small town friend Patricia "Trish" Kaek and her former flame Cole Mississippi - made their way to the ice skating jamboree where they competed against rivals old and new, winning the Nut Slide, and are about to start a dangerous Chestnut Hockey game with Cole on one side and the rest of the team on the other. Can these heroes win the game AND stop a nuclear submarine, or will the Devil Divers irradiate America's supply of bottled water!? Enjoying Hallmark: Never Stop Blowing Up?- Consider becoming a Patron of Dumb-Dumbs & Dice for as little as $1 a month and gain access to a ton of extra BTS fun (https://www.patreon.com/dumbdumbdice)- Buy merch on our website (https://dumbdumbdice.com/)- Watch us on YouTube (https://youtube.com/@dumbdumbdice)- Follow us on Instagram (https://instagram.com/dumbdumbdice)- Follow us on Facebook (https://facebook.com/dumbdumbdice) Our Cast:Game Master - Ryan LaPlanteHolly Ringer - Del BorovicCole Mississippi - Guy BradfordPatricia Kaek - Pam SparrowJohnny Evans - Josh HalbotOur Crew:Editor - Ryan LaPlanteSound Editor - Laura HamstraArtwork by the brilliant Del Borovic- Website & Portfolio (https://delborovic.com/)- X/Twitter (https://twitter.com/deltastic)

Hallmark Never Stop Blowing Up - Episode 8 - The Nut Slide

Dumb-Dumbs & Dragons: A Dungeons & Dragons Podcast

Play Episode Listen Later Dec 17, 2024 46:18

Our Hallmark Heroes - the conflicted Holly Ringer, her big city boyfriend Johnny Evans, her small town friend Patricia "Trish" Kaek and her former flame Cole Mississippi - recovered from their injuries at Grandma Ringer's house! Trish used her nursing skills to make sure Cole survived his injuries, Holly helped though she was constantly distracted by her boyfriend, and Johnny ate all the muffin tops in the house and was given a family engagement ring by Grandma! Can they win the community nut slide and chestnut hockey game - all while defeating a nuclear sub that's threatening America's water supply? Or will Polaris Rome, international terrorist for hire, and his Devil Divers complete their evil plans!?Enjoying Hallmark: Never Stop Blowing Up?- Consider becoming a Patron of Dumb-Dumbs & Dice for as little as $1 a month and gain access to a ton of extra BTS fun (https://www.patreon.com/dumbdumbdice)- Buy merch on our website (https://dumbdumbdice.com/)- Watch us on YouTube (https://youtube.com/@dumbdumbdice)- Follow us on Instagram (https://instagram.com/dumbdumbdice)- Follow us on Facebook (https://facebook.com/dumbdumbdice) Our Cast:Game Master - Ryan LaPlanteHolly Ringer - Del BorovicCole Mississippi - Guy BradfordPatricia Kaek - Pam SparrowJohnny Evans - Josh HalbotOur Crew:Editor - Ryan LaPlanteSound Editor - Laura HamstraArtwork by the brilliant Del Borovic- Website & Portfolio (https://delborovic.com/)- X/Twitter (https://twitter.com/deltastic)

Hallmark Never Stop Blowing Up - Episode 2 - Escaping Hallmark

Play Episode Listen Later Dec 16, 2024 50:15

Our Hallmark Heroes - the conflicted Holly Ringer, her big city boyfriend Johnny Evans, her small town friend Patricia "Trish" Kaek and her former flame Cole Mississippi - are shocked when the town of Hallmark is assaulted by the forces of Polaris Rome, international terrorist for hire. Can they escape the tree lighting ceremony, or will they fall into the hands of his army of madmen (and women) [and they/thems]?! Enjoying Hallmark Never Stop Blowing Up?- Consider becoming a Patron of Dumb-Dumbs & Dice for as little as $1 a month and gain access to a ton of extra BTS fun (https://www.patreon.com/dumbdumbdice)- Buy merch on our website (https://dumbdumbdice.com/)- Watch us on YouTube (https://youtube.com/@dumbdumbdice)- Follow us on Instagram (https://instagram.com/dumbdumbdice)- Follow us on Facebook (https://facebook.com/dumbdumbdice) Our Cast:Game Master - Ryan LaPlanteHolly Ringer - Del BorovicCole Mississippi - Guy BradfordPatricia Kaek - Pam SparrowJohnny Evans - Josh HalbotOur Crew:Editor - Ryan LaPlanteSound Editor - Laura HamstraArtwork by the brilliant Del Borovic- Website & Portfolio (https://delborovic.com/)- X/Twitter (https://twitter.com/deltastic)

Hallmark Never Stop Blowing Up - Episode 1 - Heading Home to Hallmark

Dumb-Dumbs & Dragons: A Dungeons & Dragons Podcast

Play Episode Listen Later Dec 16, 2024 75:06

Holly Ringer is returning to the town of Hallmark after her mother's death, meets her best friend Patty Kaek, reconnects with her high-school crush Cole Mississippi, and is surprised by her celebrity boyfriend Johnny Evans before the Chestnut Festival begins with a tree-lighting ceremony none of them will ever forget. Enjoying Hallmark Never Stop Blowing Up?- Consider becoming a Patron of Dumb-Dumbs & Dice for as little as $1 a month and gain access to a ton of extra BTS fun (https://www.patreon.com/dumbdumbdice)- Buy merch on our website (https://dumbdumbdice.com/)- Watch us on YouTube (https://youtube.com/@dumbdumbdice)- Follow us on Instagram (https://instagram.com/dumbdumbdice)- Follow us on Facebook (https://facebook.com/dumbdumbdice) Our Cast:Game Master - Ryan LaPlanteHolly Ringer - Del BorovicCole Mississippi - Guy BradfordPatricia Kaek - Pam SparrowJohnny Evans - Josh HalbotOur Crew:Editor - Ryan LaPlanteSound Editor - Laura HamstraArtwork by the brilliant Del Borovic- Website & Portfolio (https://delborovic.com/)- X/Twitter (https://twitter.com/deltastic)

Hallmark Never Stop Blowing Up - Episode 2 - Escaping Hallmark

Jesters of Ravenloft: A D&D Podcast

Play Episode Listen Later Dec 16, 2024 50:15

Our Hallmark Heroes - the conflicted Holly Ringer, her big city boyfriend Johnny Evans, her small town friend Patricia "Trish" Kaek and her former flame Cole Mississippi - are shocked when the town of Hallmark is assaulted by the forces of Polaris Rome, international terrorist for hire. Can they escape the tree lighting ceremony, or will they fall into the hands of his army of madmen (and women) [and they/thems]?! Enjoying Hallmark Never Stop Blowing Up?- Consider becoming a Patron of Dumb-Dumbs & Dice for as little as $1 a month and gain access to a ton of extra BTS fun (https://www.patreon.com/dumbdumbdice)- Buy merch on our website (https://dumbdumbdice.com/)- Watch us on YouTube (https://youtube.com/@dumbdumbdice)- Follow us on Instagram (https://instagram.com/dumbdumbdice)- Follow us on Facebook (https://facebook.com/dumbdumbdice) Our Cast:Game Master - Ryan LaPlanteHolly Ringer - Del BorovicCole Mississippi - Guy BradfordPatricia Kaek - Pam SparrowJohnny Evans - Josh HalbotOur Crew:Editor - Ryan LaPlanteSound Editor - Laura HamstraArtwork by the brilliant Del Borovic- Website & Portfolio (https://delborovic.com/)- X/Twitter (https://twitter.com/deltastic)

Special Announcement: OUR NEWEST SHOW!

Jesters of Ravenloft: A D&D Podcast

Play Episode Listen Later Dec 16, 2024 1:45

We're giving you the chance to hear the first two episodes of our amazing holiday special mini-series “Hallmark Never Stop Blowing Up” - if you enjoy it, follow the rest of the series!On Youtube: https://youtube.com/playlist?list=PLqfSLDny7bKooPXShVVwF_0LKFI9GDtUB&si=AKcUw140sE5uuzqcOn Spotify: https://open.spotify.com/show/6oHtBMayQyD5J79TGXwbyF?si=8a598a1f8e6b4911Or you can find Hallmark Never Stop Blowing Up by searching anywhere podcasts can be found (and if it isn't on your player of choice, hit us up on our socials @dumbdumbdice)

action holiday special newest hallmark special announcement dropout ttrpg action movies hallmark movies nerd news ify nwadiwe brennan lee mulligan dimension 20 rekha shankar g13 jacob wysocki sam reich

Hallmark Never Stop Blowing Up - Episode 1 - Heading Home to Hallmark

Jesters of Ravenloft: A D&D Podcast

Play Episode Listen Later Dec 16, 2024 75:06

Holly Ringer is returning to the town of Hallmark after her mother's death, meets her best friend Patty Kaek, reconnects with her high-school crush Cole Mississippi, and is surprised by her celebrity boyfriend Johnny Evans before the Chestnut Festival begins with a tree-lighting ceremony none of them will ever forget. Enjoying Hallmark Never Stop Blowing Up?- Consider becoming a Patron of Dumb-Dumbs & Dice for as little as $1 a month and gain access to a ton of extra BTS fun (https://www.patreon.com/dumbdumbdice)- Buy merch on our website (https://dumbdumbdice.com/)- Watch us on YouTube (https://youtube.com/@dumbdumbdice)- Follow us on Instagram (https://instagram.com/dumbdumbdice)- Follow us on Facebook (https://facebook.com/dumbdumbdice) Our Cast:Game Master - Ryan LaPlanteHolly Ringer - Del BorovicCole Mississippi - Guy BradfordPatricia Kaek - Pam SparrowJohnny Evans - Josh HalbotOur Crew:Editor - Ryan LaPlanteSound Editor - Laura HamstraArtwork by the brilliant Del Borovic- Website & Portfolio (https://delborovic.com/)- X/Twitter (https://twitter.com/deltastic)

Hallmark Never Stop Blowing Up - Episode 1 - Heading Home to Hallmark

Blood & Syrup: A Vampire the Masquerade Podcast

Play Episode Listen Later Dec 16, 2024 75:06

Holly Ringer is returning to the town of Hallmark after her mother's death, meets her best friend Patty Kaek, reconnects with her high-school crush Cole Mississippi, and is surprised by her celebrity boyfriend Johnny Evans before the Chestnut Festival begins with a tree-lighting ceremony none of them will ever forget. Enjoying Hallmark Never Stop Blowing Up?- Consider becoming a Patron of Dumb-Dumbs & Dice for as little as $1 a month and gain access to a ton of extra BTS fun (https://www.patreon.com/dumbdumbdice)- Buy merch on our website (https://dumbdumbdice.com/)- Watch us on YouTube (https://youtube.com/@dumbdumbdice)- Follow us on Instagram (https://instagram.com/dumbdumbdice)- Follow us on Facebook (https://facebook.com/dumbdumbdice) Our Cast:Game Master - Ryan LaPlanteHolly Ringer - Del BorovicCole Mississippi - Guy BradfordPatricia Kaek - Pam SparrowJohnny Evans - Josh HalbotOur Crew:Editor - Ryan LaPlanteSound Editor - Laura HamstraArtwork by the brilliant Del Borovic- Website & Portfolio (https://delborovic.com/)- X/Twitter (https://twitter.com/deltastic)

Hallmark Never Stop Blowing Up - Episode 2 - Escaping Hallmark

Blood & Syrup: A Vampire the Masquerade Podcast

Play Episode Listen Later Dec 16, 2024 50:15

Our Hallmark Heroes - the conflicted Holly Ringer, her big city boyfriend Johnny Evans, her small town friend Patricia "Trish" Kaek and her former flame Cole Mississippi - are shocked when the town of Hallmark is assaulted by the forces of Polaris Rome, international terrorist for hire. Can they escape the tree lighting ceremony, or will they fall into the hands of his army of madmen (and women) [and they/thems]?! Enjoying Hallmark Never Stop Blowing Up?- Consider becoming a Patron of Dumb-Dumbs & Dice for as little as $1 a month and gain access to a ton of extra BTS fun (https://www.patreon.com/dumbdumbdice)- Buy merch on our website (https://dumbdumbdice.com/)- Watch us on YouTube (https://youtube.com/@dumbdumbdice)- Follow us on Instagram (https://instagram.com/dumbdumbdice)- Follow us on Facebook (https://facebook.com/dumbdumbdice) Our Cast:Game Master - Ryan LaPlanteHolly Ringer - Del BorovicCole Mississippi - Guy BradfordPatricia Kaek - Pam SparrowJohnny Evans - Josh HalbotOur Crew:Editor - Ryan LaPlanteSound Editor - Laura HamstraArtwork by the brilliant Del Borovic- Website & Portfolio (https://delborovic.com/)- X/Twitter (https://twitter.com/deltastic)

Hallmark Never Stop Blowing Up - Episode 1 - Heading Home to Hallmark

Curse, Code & Crown

Play Episode Listen Later Dec 16, 2024 75:06

Holly Ringer is returning to the town of Hallmark after her mother's death, meets her best friend Patty Kaek, reconnects with her high-school crush Cole Mississippi, and is surprised by her celebrity boyfriend Johnny Evans before the Chestnut Festival begins with a tree-lighting ceremony none of them will ever forget. Enjoying Hallmark Never Stop Blowing Up?- Consider becoming a Patron of Dumb-Dumbs & Dice for as little as $1 a month and gain access to a ton of extra BTS fun (https://www.patreon.com/dumbdumbdice)- Buy merch on our website (https://dumbdumbdice.com/)- Watch us on YouTube (https://youtube.com/@dumbdumbdice)- Follow us on Instagram (https://instagram.com/dumbdumbdice)- Follow us on Facebook (https://facebook.com/dumbdumbdice) Our Cast:Game Master - Ryan LaPlanteHolly Ringer - Del BorovicCole Mississippi - Guy BradfordPatricia Kaek - Pam SparrowJohnny Evans - Josh HalbotOur Crew:Editor - Ryan LaPlanteSound Editor - Laura HamstraArtwork by the brilliant Del Borovic- Website & Portfolio (https://delborovic.com/)- X/Twitter (https://twitter.com/deltastic)

Hallmark Never Stop Blowing Up - Episode 2 - Escaping Hallmark

Curse, Code & Crown

Play Episode Listen Later Dec 16, 2024 50:15

Our Hallmark Heroes - the conflicted Holly Ringer, her big city boyfriend Johnny Evans, her small town friend Patricia "Trish" Kaek and her former flame Cole Mississippi - are shocked when the town of Hallmark is assaulted by the forces of Polaris Rome, international terrorist for hire. Can they escape the tree lighting ceremony, or will they fall into the hands of his army of madmen (and women) [and they/thems]?! Enjoying Hallmark Never Stop Blowing Up?- Consider becoming a Patron of Dumb-Dumbs & Dice for as little as $1 a month and gain access to a ton of extra BTS fun (https://www.patreon.com/dumbdumbdice)- Buy merch on our website (https://dumbdumbdice.com/)- Watch us on YouTube (https://youtube.com/@dumbdumbdice)- Follow us on Instagram (https://instagram.com/dumbdumbdice)- Follow us on Facebook (https://facebook.com/dumbdumbdice) Our Cast:Game Master - Ryan LaPlanteHolly Ringer - Del BorovicCole Mississippi - Guy BradfordPatricia Kaek - Pam SparrowJohnny Evans - Josh HalbotOur Crew:Editor - Ryan LaPlanteSound Editor - Laura HamstraArtwork by the brilliant Del Borovic- Website & Portfolio (https://delborovic.com/)- X/Twitter (https://twitter.com/deltastic)

Hallmark Never Stop Blowing Up - Episode 7 - Grandma's House

Warhammer 40,000: The Valentyne Heresy

Play Episode Listen Later Dec 16, 2024 50:43

Our Hallmark Heroes - the conflicted Holly Ringer, her big city boyfriend Johnny Evans, her small town friend Patricia "Trish" Kaek and her former flame Cole Mississippi - split into pairs! Trish and Johnny burned down the Fimblewinter Ski Resort to distract the terrorists and allow the group to escape, while Holly and Cole reconnected on a ski lift before falling off of it and Cole almost dying. Having reunited in the chicken truck, can they make it back to Grandma's safely, or will they fall victim to Polaris Rome, international terrorist for hire and doom both Hallmark and America?! Enjoying Hallmark: Never Stop Blowing Up?- Consider becoming a Patron of Dumb-Dumbs & Dice for as little as $1 a month and gain access to a ton of extra BTS fun (https://www.patreon.com/dumbdumbdice)- Buy merch on our website (https://dumbdumbdice.com/)- Watch us on YouTube (https://youtube.com/@dumbdumbdice)- Follow us on Instagram (https://instagram.com/dumbdumbdice)- Follow us on Facebook (https://facebook.com/dumbdumbdice) Our Cast:Game Master - Ryan LaPlanteHolly Ringer - Del BorovicCole Mississippi - Guy BradfordPatricia Kaek - Pam SparrowJohnny Evans - Josh HalbotOur Crew:Editor - Ryan LaPlanteSound Editor - Laura HamstraArtwork by the brilliant Del Borovic- Website & Portfolio (https://delborovic.com/)- X/Twitter (https://twitter.com/deltastic)

Hallmark Never Stop Blowing Up - Episode 1 - Heading Home to Hallmark

Play Episode Listen Later Dec 16, 2024 75:06

Holly Ringer is returning to the town of Hallmark after her mother's death, meets her best friend Patty Kaek, reconnects with her high-school crush Cole Mississippi, and is surprised by her celebrity boyfriend Johnny Evans before the Chestnut Festival begins with a tree-lighting ceremony none of them will ever forget. Enjoying Hallmark Never Stop Blowing Up?- Consider becoming a Patron of Dumb-Dumbs & Dice for as little as $1 a month and gain access to a ton of extra BTS fun (https://www.patreon.com/dumbdumbdice)- Buy merch on our website (https://dumbdumbdice.com/)- Watch us on YouTube (https://youtube.com/@dumbdumbdice)- Follow us on Instagram (https://instagram.com/dumbdumbdice)- Follow us on Facebook (https://facebook.com/dumbdumbdice) Our Cast:Game Master - Ryan LaPlanteHolly Ringer - Del BorovicCole Mississippi - Guy BradfordPatricia Kaek - Pam SparrowJohnny Evans - Josh HalbotOur Crew:Editor - Ryan LaPlanteSound Editor - Laura HamstraArtwork by the brilliant Del Borovic- Website & Portfolio (https://delborovic.com/)- X/Twitter (https://twitter.com/deltastic)

Hallmark Never Stop Blowing Up - Episode 2 - Escaping Hallmark

Warhammer 40,000: The Valentyne Heresy

Play Episode Listen Later Dec 16, 2024 50:15

Our Hallmark Heroes - the conflicted Holly Ringer, her big city boyfriend Johnny Evans, her small town friend Patricia "Trish" Kaek and her former flame Cole Mississippi - are shocked when the town of Hallmark is assaulted by the forces of Polaris Rome, international terrorist for hire. Can they escape the tree lighting ceremony, or will they fall into the hands of his army of madmen (and women) [and they/thems]?! Enjoying Hallmark Never Stop Blowing Up?- Consider becoming a Patron of Dumb-Dumbs & Dice for as little as $1 a month and gain access to a ton of extra BTS fun (https://www.patreon.com/dumbdumbdice)- Buy merch on our website (https://dumbdumbdice.com/)- Watch us on YouTube (https://youtube.com/@dumbdumbdice)- Follow us on Instagram (https://instagram.com/dumbdumbdice)- Follow us on Facebook (https://facebook.com/dumbdumbdice) Our Cast:Game Master - Ryan LaPlanteHolly Ringer - Del BorovicCole Mississippi - Guy BradfordPatricia Kaek - Pam SparrowJohnny Evans - Josh HalbotOur Crew:Editor - Ryan LaPlanteSound Editor - Laura HamstraArtwork by the brilliant Del Borovic- Website & Portfolio (https://delborovic.com/)- X/Twitter (https://twitter.com/deltastic)

Hallmark Never Stop Blowing Up - Episode 2 - Escaping Hallmark

Canada by Night: A Vampire the Masquerade Podcast

Play Episode Listen Later Dec 16, 2024 50:15

Our Hallmark Heroes - the conflicted Holly Ringer, her big city boyfriend Johnny Evans, her small town friend Patricia "Trish" Kaek and her former flame Cole Mississippi - are shocked when the town of Hallmark is assaulted by the forces of Polaris Rome, international terrorist for hire. Can they escape the tree lighting ceremony, or will they fall into the hands of his army of madmen (and women) [and they/thems]?! Enjoying Hallmark Never Stop Blowing Up?- Consider becoming a Patron of Dumb-Dumbs & Dice for as little as $1 a month and gain access to a ton of extra BTS fun (https://www.patreon.com/dumbdumbdice)- Buy merch on our website (https://dumbdumbdice.com/)- Watch us on YouTube (https://youtube.com/@dumbdumbdice)- Follow us on Instagram (https://instagram.com/dumbdumbdice)- Follow us on Facebook (https://facebook.com/dumbdumbdice) Our Cast:Game Master - Ryan LaPlanteHolly Ringer - Del BorovicCole Mississippi - Guy BradfordPatricia Kaek - Pam SparrowJohnny Evans - Josh HalbotOur Crew:Editor - Ryan LaPlanteSound Editor - Laura HamstraArtwork by the brilliant Del Borovic- Website & Portfolio (https://delborovic.com/)- X/Twitter (https://twitter.com/deltastic)

Hallmark Never Stop Blowing Up - Episode 1 - Heading Home to Hallmark

Canada by Night: A Vampire the Masquerade Podcast

Play Episode Listen Later Dec 16, 2024 75:06

Holly Ringer is returning to the town of Hallmark after her mother's death, meets her best friend Patty Kaek, reconnects with her high-school crush Cole Mississippi, and is surprised by her celebrity boyfriend Johnny Evans before the Chestnut Festival begins with a tree-lighting ceremony none of them will ever forget. Enjoying Hallmark Never Stop Blowing Up?- Consider becoming a Patron of Dumb-Dumbs & Dice for as little as $1 a month and gain access to a ton of extra BTS fun (https://www.patreon.com/dumbdumbdice)- Buy merch on our website (https://dumbdumbdice.com/)- Watch us on YouTube (https://youtube.com/@dumbdumbdice)- Follow us on Instagram (https://instagram.com/dumbdumbdice)- Follow us on Facebook (https://facebook.com/dumbdumbdice) Our Cast:Game Master - Ryan LaPlanteHolly Ringer - Del BorovicCole Mississippi - Guy BradfordPatricia Kaek - Pam SparrowJohnny Evans - Josh HalbotOur Crew:Editor - Ryan LaPlanteSound Editor - Laura HamstraArtwork by the brilliant Del Borovic- Website & Portfolio (https://delborovic.com/)- X/Twitter (https://twitter.com/deltastic)

Hallmark Never Stop Blowing Up - Episode 6 - Stargazing and Flamethrowers

Play Episode Listen Later Dec 13, 2024 43:01

Our Hallmark Heroes - the conflicted Holly Ringer, her big city boyfriend Johnny Evans, her small town friend Patricia "Trish" Kaek and her former flame Cole Mississippi - have deactivated LOLJK, killed Primrose Pierce to protect the internet (and Johnny Evan's affair), and Trish defeated Janice Fimblewinter, winning the Chestnut 32,000 ski race. Can they continue their winning streak to save the town of Hallmark and ultimately America, or will the entire nation fall victim to Polaris Rome, international terrorist for hire?! Enjoying Hallmark: Never Stop Blowing Up?- Consider becoming a Patron of Dumb-Dumbs & Dice for as little as $1 a month and gain access to a ton of extra BTS fun (https://www.patreon.com/dumbdumbdice)- Buy merch on our website (https://dumbdumbdice.com/)- Watch us on YouTube (https://youtube.com/@dumbdumbdice)- Follow us on Instagram (https://instagram.com/dumbdumbdice)- Follow us on Facebook (https://facebook.com/dumbdumbdice) Our Cast:Game Master - Ryan LaPlanteHolly Ringer - Del BorovicCole Mississippi - Guy BradfordPatricia Kaek - Pam SparrowJohnny Evans - Josh HalbotOur Crew:Editor - Ryan LaPlanteSound Editor - Laura HamstraArtwork by the brilliant Del Borovic- Website & Portfolio (https://delborovic.com/)- X/Twitter (https://twitter.com/deltastic)

Hallmark Never Stop Blowing Up - Episode 5 - The Chestnut 32,000

Play Episode Listen Later Dec 12, 2024 42:52

Our Hallmark Heroes - the conflicted Holly Ringer, her big city boyfriend Johnny Evans, her small town friend Patricia "Trish" Kaek and her former flame Cole Mississippi - have connected with an America Force deep cover agent and made their way into the server farms hidden under the Fimblewinter ski resort. Having destroyed the drone swarm, can they take out the Hacker Prime and her robot bodyguard LOLJK, or will Primrose Pierce get away and blackmail everyone in America?! Enjoying Hallmark: Never Stop Blowing Up?- Consider becoming a Patron of Dumb-Dumbs & Dice for as little as $1 a month and gain access to a ton of extra BTS fun (https://www.patreon.com/dumbdumbdice)- Buy merch on our website (https://dumbdumbdice.com/)- Watch us on YouTube (https://youtube.com/@dumbdumbdice)- Follow us on Instagram (https://instagram.com/dumbdumbdice)- Follow us on Facebook (https://facebook.com/dumbdumbdice) Our Cast:Game Master - Ryan LaPlanteHolly Ringer - Del BorovicCole Mississippi - Guy BradfordPatricia Kaek - Pam SparrowJohnny Evans - Josh HalbotOur Crew:Editor - Ryan LaPlanteSound Editor - Laura HamstraArtwork by the brilliant Del Borovic- Website & Portfolio (https://delborovic.com/)- X/Twitter (https://twitter.com/deltastic)

Hallmark Never Stop Blowing Up - Episode 4 - INFAMOUS

Play Episode Listen Later Dec 11, 2024 47:46

Our Hallmark Heroes - the conflicted Holly Ringer, her big city boyfriend Johnny Evans, her small town friend Patricia "Trish" Kaek and her former flame Cole Mississippi - have discovered that Hallmark is ACTUALLY the heart of modern day America and the President of the United States is sending them back to save it. Can these small town heroes channel the chestnut juice in their veins and save their town and their country, or will everyone fall victim to Polaris Rome, international terrorist for hire?! Enjoying Hallmark: Never Stop Blowing Up?- Consider becoming a Patron of Dumb-Dumbs & Dice for as little as $1 a month and gain access to a ton of extra BTS fun (https://www.patreon.com/dumbdumbdice)- Buy merch on our website (https://dumbdumbdice.com/)- Watch us on YouTube (https://youtube.com/@dumbdumbdice)- Follow us on Instagram (https://instagram.com/dumbdumbdice)- Follow us on Facebook (https://facebook.com/dumbdumbdice) Our Cast:Game Master - Ryan LaPlanteHolly Ringer - Del BorovicCole Mississippi - Guy BradfordPatricia Kaek - Pam SparrowJohnny Evans - Josh HalbotOur Crew:Editor - Ryan LaPlanteSound Editor - Laura HamstraArtwork by the brilliant Del Borovic- Website & Portfolio (https://delborovic.com/)- X/Twitter (https://twitter.com/deltastic)

Hallmark Never Stop Blowing Up - Episode 2 - Escaping Hallmark

Play Episode Listen Later Dec 10, 2024 50:15

Our Hallmark Heroes - the conflicted Holly Ringer, her big city boyfriend Johnny Evans, her small town friend Patricia "Trish" Kaek and her former flame Cole Mississippi - are shocked when the town of Hallmark is assaulted by the forces of Polaris Rome, international terrorist for hire. Can they escape the tree lighting ceremony, or will they fall into the hands of his army of madmen (and women) [and they/thems]?! Enjoying Hallmark Never Stop Blowing Up?- Consider becoming a Patron of Dumb-Dumbs & Dice for as little as $1 a month and gain access to a ton of extra BTS fun (https://www.patreon.com/dumbdumbdice)- Buy merch on our website (https://dumbdumbdice.com/)- Watch us on YouTube (https://youtube.com/@dumbdumbdice)- Follow us on Instagram (https://instagram.com/dumbdumbdice)- Follow us on Facebook (https://facebook.com/dumbdumbdice) Our Cast:Game Master - Ryan LaPlanteHolly Ringer - Del BorovicCole Mississippi - Guy BradfordPatricia Kaek - Pam SparrowJohnny Evans - Josh HalbotOur Crew:Editor - Ryan LaPlanteSound Editor - Laura HamstraArtwork by the brilliant Del Borovic- Website & Portfolio (https://delborovic.com/)- X/Twitter (https://twitter.com/deltastic)

Hallmark Never Stop Blowing Up - Episode 3 - The Heart of America

Play Episode Listen Later Dec 10, 2024 50:02

Our Hallmark Heroes - the conflicted Holly Ringer, her big city boyfriend Johnny Evans, her small town friend Patricia "Trish" Kaek and her former flame Cole Mississippi - have stolen a bus from the criminals of the Crooked Carnival and are attempting to reach a short wave radio to let the government know what's happening in Hallmark. Can they summon help or will they be captured by the evil minions of Polaris Rome, international terrorist for hire?! Enjoying Hallmark Never Stop Blowing Up?- Consider becoming a Patron of Dumb-Dumbs & Dice for as little as $1 a month and gain access to a ton of extra BTS fun (https://www.patreon.com/dumbdumbdice)- Buy merch on our website (https://dumbdumbdice.com/)- Watch us on YouTube (https://youtube.com/@dumbdumbdice)- Follow us on Instagram (https://instagram.com/dumbdumbdice)- Follow us on Facebook (https://facebook.com/dumbdumbdice) Our Cast:Game Master - Ryan LaPlanteHolly Ringer - Del BorovicCole Mississippi - Guy BradfordPatricia Kaek - Pam SparrowJohnny Evans - Josh HalbotOur Crew:Editor - Ryan LaPlanteSound Editor - Laura HamstraArtwork by the brilliant Del Borovic- Website & Portfolio (https://delborovic.com/)- X/Twitter (https://twitter.com/deltastic)

Hallmark Never Stop Blowing Up - Episode 1 - Heading Home to Hallmark

science guillaume footsteps impromptu debris g13

Play Episode Listen Later Dec 9, 2024 75:06

Holly Ringer is returning to the town of Hallmark after her mother's death, meets her best friend Patty Kaek, reconnects with her high-school crush Cole Mississippi, and is surprised by her celebrity boyfriend Johnny Evans before the Chestnut Festival begins with a tree-lighting ceremony none of them will ever forget. Enjoying Hallmark Never Stop Blowing Up?- Consider becoming a Patron of Dumb-Dumbs & Dice for as little as $1 a month and gain access to a ton of extra BTS fun (https://www.patreon.com/dumbdumbdice)- Buy merch on our website (https://dumbdumbdice.com/)- Watch us on YouTube (https://youtube.com/@dumbdumbdice)- Follow us on Instagram (https://instagram.com/dumbdumbdice)- Follow us on Facebook (https://facebook.com/dumbdumbdice) Our Cast:Game Master - Ryan LaPlanteHolly Ringer - Del BorovicCole Mississippi - Guy BradfordPatricia Kaek - Pam SparrowJohnny Evans - Josh HalbotOur Crew:Editor - Ryan LaPlanteSound Editor - Laura HamstraArtwork by the brilliant Del Borovic- Website & Portfolio (https://delborovic.com/)- X/Twitter (https://twitter.com/deltastic)

Illegal Paris Grows, Moving Packs In Amsterdam, & Winning 18 Cannabis Cups: T.H. Seeds Story

First Smoke of The Day

Play Episode Listen Later Oct 14, 2024 108:36

If you feel like you know the real story of the cannabis scene exploding in Europe in the early 90s and 2000s, prepare to rewrite your history books with this episode with one of the true godfathers of herb.Blackleaf is joined by international cannabis icon and lore keeper, Julian of TH Seeds, to hear his first-hand accounts of trapping indoor grows in Paris, moving packs to Amsterdam during its hay day, learning under Scott Blakey aka Shantibaba himself, and winning over 18 cannabis cups over his career since the early 1990s.Julian dives deep into the formation of the famous Greenhouse Seeds, arguably the most successful cannabis business in the world, and winner of over 42 High Times Cannabis Cups since 1985. Along the way, you'll hear never-before-heard origin stories of other legendary seed banks like Mr. Nice and Archive Seed Bank, and the relationship that Mr. Nice, Julian, Arjan, and Neville all shared during those times.Blackleaf comes swinging with some huge questions during this episode such as whether or not Skunk is dead and whether good weed needs to even be over 15-18% THC. Julian responds with his in-depth opinion on the European weed market, highlighting the booming Barcelona market, and reassuring Blackleaf that iconic cultivars like Skunk, Haze, G13, White Widow, and White Rhino all still have original cuts floating around Europe from the OGs that are either still on shelves or could be revived.Throughout this pod, Julian weighs in heavily on his opinions on the state of the American weed market, claiming it moves too quickly and doesn't pay enough homage to the time-honored commercial genetics that has spawned the designer hybrids we see come and go so quickly today, as well as why Barcelona has become the new hub for all of the seasoned Dutch growers.This is hands-down one of the most interesting guests we've ever had on FSOTD in terms of stake in the culture. Julian easily has over 30 years of experience hunting genetics, feminizing seeds, cultivating fire weed, and is now working with his partners to help enormous commercial grows around Europe hunt their own proprietary genetics and maximize their systems.Subscribe to our channel and the FSOTD.com site to keep up with other key players and enjoy conversations with originators of the culture you can't find anywhere else. Hosted on Acast. See acast.com/privacy for more information.

american europe moving european winning barcelona amsterdam dutch cannabis acast seeds illegal grows thc cups neville ogs packs haze skunk arjan white rhinos white widow g13

Impromptu Science (49)

Trackside Science

Play Episode Listen Later Sep 9, 2024 59:21

No plan or pre-recording preparation whatsoever…the difference between dentists & endodontists… old microscopes… Rob's home office inspection… regulation of medical data.. college graduation in state prisons.. pubpeer.com… problematic paper screener … (https://www.irit.fr/~Guillaume.Cabanac/problematic-paper-screener)... Jeff's anxiety about teaching in the federal prison (update, students were nice but it was way more difficult teaching there than the state prison) RIP Vanessa, Rob's former colleague in South Dakota Alcohol Jeff - All the Holiday Things, Wild Leap Brewing Rob - Be Hoppy Pale Ale, Wormtown Brewing Sounds & Music All sound are from freesound.org unless otherwise noted Opening bit: Squeaky Car Door (coltures) Car Acceleration Inside Car.wav (alexftw123) City ambience with soft rain…(felix.blume) Opening a door in the city and going inside (evsecrets) engine_turn_signal_subaru_forester_1989. (mario1298) G13-46-Abrupt Car Stop.wav(craigsmith) Footsteps on tiled bathroom (brandonb1111) service_elavator.mp3 by morgantj Car Explosion w Debris.mp3 by PNMCarrieRailfan

EP #423 - Thomas Crawford & Daniel Delouya: Building AI-Powered Insurance

Swisspreneur Show

Play Episode Listen Later Jul 28, 2024 19:21

Timestamps: 2:00 - The insurance market so far 5:58 - The rise of AI tools 8:15 - Signing the first 4 commercial agreements 8:47 - Finding AI engineering talent 14:11 - Fundraising through the Swisspreneur Syndicate About Thomas Crawford & Daniel Delouya: Thomas Crawford is the co-founder and CEO of Bind, a startup providing AI-powered insurance targeting. He holds a BA in Geography and Economics from Durham University and previously worked for Zurich Insurance before joining Bind as a late co-founder in 2024. Daniel Delouya is the co-founder and COO of Bind. He previously co-founded two companies, the social discovery app Blume and the smart home automation platform G13, before starting Bind in 2022. Bind makes it easy for businesses to better understand and target customers with relevant insurance products at scale. Their proprietary AI technology is wrapped in a simple-to-use API that businesses can implement with ease. They strategically leverage Switzerland's central location to facilitate seamless access to global markets. Bind is currently raising CHF 1.5M, part of which is being done through the Swisspreneur Syndicate. Check out our dealflow page to learn more about the deal. Don't forget to give us a follow on⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Twitter⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠,⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Instagram⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠,⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Facebook⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠and⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Linkedin⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠, so you can always stay up to date with our latest initiatives. That way, there's no excuse for missing out on live shows, weekly giveaways or founders' dinners.

ceo ai economics coo switzerland insurance signing fundraising api crawford geography 5m bind ai powered blume durham university chf zurich insurance g13

How to Ride the Stock Market Wave | 4.5.24 OVTLYR Trading Room

How to Trade Stocks and Options Podcast by 10minutestocktrader.com

Play Episode Listen Later Apr 9, 2024 16:00

Dive into the world of stock trading with our latest video revealing the secrets of the G13 strategy. Discover how this data-driven approach could revolutionize your trading game and maximize your profits. Join us as we explore the optimal trading point for unprecedented returns. #StockTrading #G13Strategy #DataDriven #MaximizeProfits #TradingGame #StockMarketTips

discover dive ride wave trading stock market g13

Vi snakker anlegg, idrett, politikk, og mye mer med Jan Thomas Birkeland

Tungvekterne - en podcast fra ØB-sporten

Play Episode Listen Later Jan 11, 2024 77:36

Det å styre et av landets største idrettslag er en krevende oppgave i seg selv. Anlegg og rammevilkår for idretten i Nordre Follo er en stor del av hverdagen. Vi snakker en del om det i dagens podkast. Politikk, kommer vi selvsagt ikke utenom når vi vet at Birkeland også sitter i kommunestyret.Vi snakker om Follos satsingslag på G13, Ski Hockey og mye mye mer.

snakker politikk birkeland jan thomas idrett mye mer g13

Linux Action News 283

Linux Action News

Play Episode Listen Later Mar 9, 2023 13:50

Nextcloud's big new customer, some last-minute surprises in GNOME 44, and Flathub's ambitious plans for 2023.

european union security productivity privacy saas governance mutter app store rust linux t mobile abi google docs m1 gpu gnome m2 microsoft office canonical lifetimes firmware deutsche telekom apple silicon action news nextcloud chris fisher linux kernel opengl flatpak asahi linux g13 gpdr gnome foundation gnome shell agx self-hosting wes payne linux news podcast

Linux Action News 283

Linux Action News

Play Episode Listen Later Mar 9, 2023 13:50

Nextcloud's big new customer, some last-minute surprises in GNOME 44, and Flathub's ambitious plans for 2023.

european union security productivity privacy saas governance mutter app store rust linux t mobile abi google docs m1 gpu gnome m2 microsoft office canonical lifetimes firmware deutsche telekom apple silicon action news nextcloud chris fisher linux kernel opengl flatpak asahi linux g13 gpdr gnome foundation gnome shell agx self-hosting wes payne linux news podcast

小人物上籃 - 霹靂鍵盤#46 報告教練！有人手指愛心不明不清。 Feat. justin教練泰霖教練

小人物上籃

Play Episode Listen Later Dec 1, 2022 101:03

月底是主持人Kong的期末考週，但是比賽還是要看，節目一樣要錄。但是怕他晚上睡覺腦子都是籃球，就盡量講少一點（？本週請到了二次回鍋的苦情教練，南港國小的教頭泰霖，還有也是在台北基層籃球育成高中的教練 justin ，陪我們先從打完預賽的HBL談起。本週比賽，領航猿終於在鋼鐵人主場拿下本季首勝，而一直處於混沌狀態的鋼鐵人到底是遇到什麼問題？在週二的平日賽事，鳳山圖書館內卻在最後打出不一樣的內容，但一樣的結局。新北國王的開季連勝紀錄終結在自己的主場，究竟夢想家使出什麼樣的法寶，讓一路連勝的國王處處受挫。就算夢想家被單換掉一個洋將與老吳手比愛心的幫助之下，國王怎麼還是大比分落敗？更多胡亂吹促進度與猿迷笑容都在本集霹靂鍵盤節目！

kong hbl g12 g13 g11

Novel Therapies Targeting KRAS in Lung Cancer & RAS-altered Tumors

ASCO Daily News

Play Episode Listen Later Nov 3, 2022 28:33

Dr. Vamsi Velcheti and Dr. Benjamin Neel, of the NYU Langone Perlmutter Cancer Center, and Dr. John Heymach, of MD Anderson Cancer Center, discuss new therapeutic approaches for KRAS-mutant lung cancers and therapy options for RAS-altered tumors. TRANSCRIPT Dr. Vamsidhar Velcheti: Hello, I'm Dr. Vamsidhar Velcheti, your guest host for the ASCO Daily News podcast today. I'm the medical director of the Thoracic Oncology Program at Perlmutter Cancer Center at NYU Langone Health. I'm delighted to welcome two internationally renowned physician-scientists, Dr. John Heymach, the chair of Thoracic-Head & Neck Medical Oncology at the MD Anderson Cancer Center, and my colleague, Dr. Benjamin Neel, the director of the Perlmutter Cancer Center at NYU Langone Health, and professor of Medicine at NYU Grossman School of Medicine. So, we'll be discussing new therapeutic approaches today for KRAS-mutant lung cancers, and we will talk about emerging new targeted therapy options for RAS-altered tumors. Our full disclosures are available in the show notes, and the disclosures of all the guests of the podcast can be found on our transcript at: asco.org/podcast. Dr. Heymach and Dr. Neel, it's such a great pleasure to have you here for the podcast today. Dr. John Heymach: My pleasure to be here. Dr. Benjamin Neel: Same here. Dr. Vamsidhar Velcheti: Dr. Neel, let's start off with you. As you know, RAS oncogenes were first discovered nearly four decades ago. Why is RAS such a challenging therapeutic target? Why has it taken so long to develop therapeutic options for these patients? Dr. Benjamin Neel: Well, I think a good analogy is the difference between kinase inhibitors and RAS inhibitors. So, kinase inhibitors basically took advantage of an ATP-binding pocket that's present in all kinases, but is different from kinase to kinase, and can be accessed by small molecule inhibitors. So, the standard approach that one would've thought of taking, would be to go after the GTP-binding pocket. The only problem is that the affinity for binding GTP by KRAS is three to four orders of magnitude higher. So, actually getting inhibitors that are GTP-binding inhibitors is pretty much very difficult. And then, until recently, it was felt that RAS was a very flat molecule and there weren't any surfaces that you could stick a small molecule inhibitor in. So, from a variety of biochemical and medicinal-pharmacological reasons, RAS was thought to be impervious to small molecule development. But as is often the case, a singular and seminal insight from a scientist, Kevan Shokat, really broke the field open, and now there's a whole host of new approaches to trying to drug RAS. Dr. Vamsidhar Velcheti: So, Dr. Neel, can you describe those recent advances in drug design that have enabled these noble new treatments for KRAS-targeted therapies? Dr. Benjamin Neel: So, it starts actually with the recognition that for many years, people were going after the wrong RAS. And by the wrong RAS, the overwhelming majority of the earlier studies on the structure, and for that matter, the function of RAS centered on HRAS or Harvey RAS. We just mutated in some cancers, most prominently, bladder cancer, and head & neck cancer, but not on KRAS, which is the really major player in terms of oncogenes in human cancer. So, first of all, we were studying the wrong RAS. The second thing is that we were sort of thinking that all RAS mutants were the same. And even from the earliest days, back in the late eighties, it was pretty clear that there were different biochemical properties in all different RAS mutants. But this sort of got lost in the cause and in the intervening time, and as a result, people thought all RASes were the same and they were just studying mainly G12V and G12D, which are more difficult to drug. And then, the third and most fundamental insight was the idea of trying to take advantage of a particular mutation in KRAS, which is present in a large fraction of lung cancer patients, which is, KRAS G12C. So, that's a mutation of glycine 12 to cysteine and Kevan's really seminal study was to use a library of covalently adducting drugs, and try to find ways to tether a small molecule in close enough so that it could hit the cysteine. And what was really surprising was when they actually found the earliest hits with this strategy, which was actually based on some early work by Jim Wells at Sunesis in the early part of this century, they found that it was actually occupying the G12C state or the inactive state of RAS. And this actually hearkens back to what I said earlier about all RASes being the same. And in fact, what's been recently re-appreciated is that some RAS mutants, most notably, G12C, although they're impervious to the gap which converts the active form into the inactive form, they still have a certain amount of intrinsic ability to convert from the inactive form. And so, they always cycle into the inactive form at some slow rate, and that allows them to be accessed by these small molecules in the so-called Switch-II Pocket, and that enables them to position a warhead close enough to the cysteine residue to make a covalent adduct and inactivate the protein irreversibly. Scientists at a large number of pharmaceutical companies and also academic labs began to understand how to access various other pockets in RAS, and also even new strategies, taking advantage of presenting molecules to RAS on a chaperone protein. So, there's now a whole host of strategies; you have a sort of an embarrassment of riches from an impoverished environment that we started with prior to 2012. Dr. Vamsidhar Velcheti: Thank you, Dr. Neel. So, Dr. Heymach, lung cancer has been a poster child for personalized therapy, and we've had like a lot of FDA-approved agents for several molecularly-defined subsets of lung cancer. How clinically impactful is a recent approval of Sotoracib for patients with metastatic lung cancer? Dr. John Heymach: Yeah. Well, I don't think it's an exaggeration to say this is the biggest advance for targeted therapies for lung cancer since the initial discovery of EGFR inhibitors. And let me talk about that in a little more detail. You know, the way that lung cancer therapy, like a lot of other cancer therapies, has advanced is by targeting specific driver oncogenes. And as Dr. Neel mentioned before, tyrosine kinases are a large percentage of those oncogenes and we've gotten very good at targeting tyrosine kinases developing inhibitors. They all sort of fit into the same ATP pocket, or at least the vast majority of them now. There are some variations on that idea now like allosteric inhibitors. And so, the field has just got better and better. And so, for lung cancer, the field evolved from EGFR to ALK, to ROS1 RET fusions, MEK, and so forth. What they all have in common is, they're all tyrosine kinases. But the biggest oncogene, and it's about twice as big as EGFR mutation, are KRAS mutations. And as you mentioned, this isn't a tyrosine kinase. We never had an inhibitor. And the first one to show that it's targetable, to have the first drug that does this, is really such an important breakthrough. Because once the big breakthrough and the concept is there, the pharmaceutical companies in the field can be really good at improving and modulating that. And that's exactly what we see. So, from that original insight that led to the design of the first G12C inhibitors, now there's dozens, literally dozens of G12C inhibitors and all these other inhibitors based on similar concepts. So, the first one now to go into the clinic and be FDA-approved is Sotoracib. So, this again, as you've heard, is inhibitor G12C, and it's what we call an irreversible inhibitor. So, it fits into this pocket, and it covalently links with G12C. So, when it's linked, it's linked, it's not coming off. Now, the study that led to its FDA approval was called the CodeBreak 100 study. And this was led in part, by my colleague Ferdinandos Skoulidis, and was published in The New England Journal in the past year. And, you know, there they studied 126 patients, and I'll keep just a brief summary, these were all refractory lung cancer patients. They either had first-line therapy, most had both chemo and immunotherapy. The primary endpoint was objective response rate. And for the study, the objective response rate was 37%, the progression-free survival was 6.8 months, the overall survival was 12.5 months. Now you might say, well, 37%, that's not as good as an EGFR inhibitor or the others. Well, this is a much harder thing to inhibit. And you have to remember in this setting, the standard of care was docetaxel chemotherapy. And docetaxel usually has a response rate of about 10 to 13%, progression-free survival of about 3 months. So, to more than double that with a targeted drug and have a longer PFS really is a major advance. But it's clear, we've got to improve on this and I think combinations are going to be incredibly important now. There's a huge number of combination regimens now in testing. Dr. Vamsidhar Velcheti: Thank you, Dr. Heymach. So, Dr. Neel, just following up on that, unlike other targeted therapies in lung cancer, like EGFR, ALK, ROS, and RET, the G12C inhibitors appear to have somewhat modest, I mean, though, certainly better than docetaxel that Dr. Heymach was just talking about; why is it so hard to have more effective inhibitor of KRAS here? Is it due to the complex nature of RAS-mutant tumors? Or is it our approach for targeting RAS? Is it a drug-related problem, or is it the disease? Dr. Benjamin Neel: Well, the short answer is I think that's a theoretical discussion at this point and there isn't really good data to tell you, but I suspect it's a combination of those things. We'll see with the new RAS(ON) inhibitors, which seem to have deeper responses, even in animal models, if those actually work better in the clinic, then we'll know at least part of it was that we weren't hitting RAS hard enough, at least with the single agents. But I also think that it's highly likely that since KRAS-mutant tumors are enriched in smokers, and smokers have lots of mutations, that they are much more complex tumours, and therefore there's many more ways for them to escape. Dr. Vamsidhar Velcheti: Dr. Heymach, you want to weigh in on that? Dr. John Heymach: Yeah, I think that's right. I guess a couple of different ways to view it is the problem that the current inhibitors are not inhibiting the target well enough, you know, in which case we say we get better and better inhibitors will inhibit it more effectively, or maybe we're inhibiting it, but we're not shutting down all the downstream pathways or the feedback pathways that get turned on in response, in which case the path forward is going to be better combinations. Right now, I think the jury is still out, but I think the data supports that we can do better with better inhibitors, there's room to grow. But it is also going to be really important hitting these compensatory pathways that get turned on. I think it's going to be both, and it seems like KRAS may turn on more compensatory pathways earlier than things like EGFR or ALK2, you know, and I think it's going to be a great scientific question to figure out why that is. Dr. Vamsidhar Velcheti: Right. And just following up on that, Dr. Heymach, so, what do we know so far about primary and acquired resistance to KRAS G12C inhibitors? Dr. John Heymach: Yeah. Well, it's a great question, and we're still very early in understanding this. And here, if we decide to call it primary resistance - meaning you never respond in the first place, and acquired - meaning you respond and then become resistant, we're not sure why some tumors do respond and don't respond initially. Now, it's been known for a long time, tumors differ in what we call their KRAS-dependence. And in cell lines and in mouse models, when you study this in the lab, there are some models where if you block KRAS, those cells will die immediately. They are fully dependent. And there's other ones that become sort of independent and they don't really seem to care if you turn down KRAS, they've sort of moved on to other things they're dependent on. One way this can happen is with undergoing EMT where the cell sort of changes its dependencies. And EMT is probably a reason some of these tumors are resistant, to start with. It may also matter what else is mutated along with KRAS, what we call the co-mutations, the additional mutations that occur along with it. For example, it seems like if this gene KEAP1 is mutated, tumors don't respond as well, to begin with. Now, acquired resistance is something we are gaining some experience with. I can say in the beginning, we all knew there'd be resistance, we were all waiting to see it, and what we were really hoping for was the case like with first-generation inhibitors with EGFR, where there was one dominant mechanism. In the first-generation EGFR, we had one mutation; T790M, that was more than half the resistance. And then we could develop drugs for that. But unfortunately, that's not the case. It looks like the resistance mechanisms are very diverse, and lots of different pathways can get turned on. So, for acquired resistance, you can have additional KRAS mutations, like you can have a KRAS G12D or V, or some other allele, or G13, I didn't even realize were commonly mutated, like H95 or Y96 can get mutated as well. So, we might be able to inhibit with better inhibitors. But the more pressing problem is what we call bypass; when these other pathways get turned on. And for bypass, we know that the tumor can turn on MET with MET amplification, NRAS, BRAF, MAP kinase, and we just see a wide variety. So, it's clear to us there isn't going to be a single easy to target solution like there was for EGFR. This is going to be a long-term problem, and we're going to have to work on a lot of different solutions and get smarter about what we're doing. Dr. Vamsidhar Velcheti: Yeah. Thank you very much, Dr. Heymach. And Dr. Neel, just following up on that, so, what do you think our strategies should be or should look like while targeting KRAS-mutant tumors? Like, do we focus on better ways to inhibit RAS, or do we focus on personalized combination approaches based on various alterations or other biomarkers? Dr. Benjamin Neel: Yeah. Well, I'd like to step back a second and be provocative, and say that we've been doing targeted therapies, so to speak, for a long time, and it's absolutely clear that targeted therapies never cure. And so, I think we should ask the bigger question, "Why is it that targeted therapies never cure?" And I would start to conceive of an answer to that question by asking which therapies do cure. And the therapies that we know do cure are immune therapies, or it's therapies that generate durable immune response against the tumor. And the other therapies that we know that are therapies in some cases against some tumors, and radiation therapy in some cases against some tumors. Probably the only way that those actually converge on the first mechanism I said that cures tumors, which is generating a durable immune response. And so, the only way, in my view, it is to durably cure an evolving disease, like a cancer, is to have an army that can fight an evolving disease. And the only army I know of is the immune system. So, I think ultimately, what we need to do is understand in detail, how all of these different mutations that lead to cancer affect immune response and create targetable lesions in the immune response, and then how the drugs we'd give affect that. So, in the big picture, the 50,000-foot picture, that what we really need to spend more attention on, is understanding how the drugs we give and the mutations that are there in the first place affect immune response against the tumor, and ultimately try to develop strategies that somehow pick up an immune response against the tumor. Now in the short run, I think there's also lots of combination strategies that we can think of, John, you know, alluded to some of them earlier. I mean one way for the G12C inhibitors, getting better occupancy of the drug, and also blocking this so-called phenomenon of adaptive resistance, where you derepress the expression of receptor tyrosine kinases, and their ligands, and therefore bypass through normal RAS or upregulate G12C into the GTP state more, that can be attacked by combining, for example, with the SHIP2 inhibitor or a SOS inhibitor. Again, the issue there will be therapeutic index. Can we achieve that with a reasonable therapeutic index? Also in some cases, like not so much in lung cancer, but in colon cancer, it appears as if a single dominant receptor tyrosine kinase pathway, the EGF receptor pathway, is often the mechanism of adaptive resistance to RAS inhibitors, and so, combining a RAS inhibitor with an EGF receptor inhibitor is a reasonable strategy. And then of course, some of the strategies they're already getting at, what I just mentioned before, which is to try to combine RAS inhibitors with checkpoint inhibitors. I think that's an expected and understandable approach, but I think we need to get a lot more sophisticated about the tumor microenvironment, and how that's affecting the immune response. And it's not just going to be, you know, in most cases combining with a checkpoint inhibitor. I think we ought to stop using the term immunotherapy to refer to checkpoint inhibitors. Checkpoint inhibitors are one type of immunotherapy. We don't refer to antibiotics when we mean penicillin. Dr. Vamsidhar Velcheti: Dr. Heymach, as you know, like, there's a lot of discussion about the role of KRAS G12C inhibitors in the frontline setting. Do you envision these drugs are going to be positioning themselves in the frontline setting as a combination, or like as a single agent? Are there like a subset of patients perhaps where you would consider like a single agent up front? Dr. John Heymach: So, I think there's no question G12C inhibitors are moving to the first-line question. And the question is just how you get there. Now, the simplest and most straightforward approach is to say, “Well, we'll take our standard and one standard might be immunotherapy alone, a PD-1 inhibitor alone, or chemo with the PD-1 inhibitor, and just take the G12C inhibitor and put it right on top.” And that's a classic strategy that's followed. That may not be that simple. It's not obvious that these drugs will always work well together or will be tolerated together. So, I think that's still being worked out. Now, an alternative strategy is you could say, “Well, let's get a foot in a door in the first-line setting by finding where chemotherapy and immunotherapy don't work well, and pick that little subgroup.” There are some studies there using STK11-mutant tumors, and they don't respond well to immunotherapy and chemotherapy and say, “Well, let's pick that first.” And that's another strategy, but that's not to get it for everybody in the first-line setting. That's just to pick a little subgroup. Or we may develop KRAS G12C inhibitor combinations by themselves that are so effective they can beat the standard. So, what I think is going to happen is a couple things; I think they'll first be some little niches where it gets in there first. I think eventually, we'll figure out how to combine them with chemotherapy and immunotherapy so it goes on top. And then I think over time, we'll eventually develop just more effective, targeted combos where we can phase out the chemo, where the chemo goes to the back of the line, and this goes to the front of the line. Dr. Vamsidhar Velcheti: And Dr. Heymach, any thoughts on the perioperative setting and the adjuvant/neoadjuvant setting, do you think there's any role for these inhibitors in the future? Dr. John Heymach: Yeah, this is a really exciting space right now. And so that makes this a really challenging question because of how quickly things are moving. I'll just briefly recap for everybody. Until recently, adjuvant therapy was just chemotherapy after you resected a lung cancer. That was it. And it provided about a 5% benefit in terms of five-year disease-free survival. Well, then we had adjuvant immunotherapy, like atezolizumab, approved, then we had neoadjuvant chemo plus immunotherapy approved; that's a CheckMate 816. And just recently, the AEGEAN study, which I'm involved with, was announced to be a positive study. That's neoadjuvant plus adjuvant chemo plus immunotherapy. So now, if you say, well, how are you going to bring a G12C inhibitor in there? Well, you can envision a few different ways; if you can combine with chemo and immunotherapy, you could bring it up front and bring it afterwards, or you could just tack it in on the back, either with immunotherapy or by itself, if you gave neoadjuvant chemo plus immunotherapy first, what we call the CheckMate 816 regimen. So, it could fit in a variety of ways. I'll just say neoadjuvant is more appealing because you can measure the response and see how well it's working, and we in fact have a neoadjuvant study going. But the long-term benefit may really come from keeping the drug going afterwards to suppress microscopic metastatic disease. And that's what I believe is going to happen. I think you're going to need to stay on these drugs for a long while to keep that microscopic disease down. Dr. Vamsidhar Velcheti: Dr. Neel, any thoughts on novel agents in development beyond KRAS G12C inhibitors? Are there any agents or combinations that you'd be excited about? Dr. Benjamin Neel: Well, I think that the YAP/TAZ pathway inhibitors, the TEAD inhibitors in particular, are potentially promising. I mean, it seems as if the MAP kinase pathway and the GAPT pathway act in parallel. There's been multiple phases which suggest that YAP/TAZ reactivation can be a mechanism of sort of state-switching resistance. And so, I think those inhibitors are different than the standard PI3 kinase pathway inhibitor, PI3 kinase mTOR inhibitor, rapamycin. I also think as we've alluded to a couple of times, the jury's still out in the clinic, of course, but it'll be very exciting to see how this new set of RAS inhibitors works. The sort of Pan-RAS inhibitors, especially the ones that hit the GTP ON state. So, the G12C inhibitors and the initial preclinical G12D inhibitors that have been recorded, they all work by targeting the inactive state of RAS, the RAS-GDP state. And so, they can only work on mutants that cycle, at least somewhat, and they also don't seem to be as potent as targeting the GTP or active state of RAS. And so, at least the Rev meds compounds, which basically use cyclophilin, they basically adapt the mechanism that cyclosporine uses to inhibit calcineurin. They basically use the same kind of a strategy and build new drugs then that bind cyclophilin and present the drug in a way that can inhibit multiple forms of RAS. So, it'll be interesting to see if they are much more efficacious in a clinic as they appear to be in the lab, whether they can be tolerated. So, I think those are things to look out for. Dr. Vamsidhar Velcheti: Dr. Heymach? Dr. John Heymach: Yeah, I agree with that. I'm excited to see that set of compounds coming along. One of the interesting observations is that when you inhibit one KRAS allele like G12C, you get these other KRAS alleles commonly popping up. And it's a little -- I just want to pause for a second to comment on this, because this is a little different than EGFR. If you inhibit a classic mutation, you don't get multiple other separate EGFR alleles popping up. You may get a secondary mutation in cyst on the same protein, but you don't get other alleles. So, this is a little different biology, but I think the frequency that we're seeing all these other KRAS alleles pop up tells us, I think we're going to need some pan-KRAS type strategy as a partner for targeting the primary driver. So for example, a G12C inhibitor plus a pan-KRAS strategy to head off these other alleles that can be popping up. So, I think that's going to be probably a minimum building block that you start putting other things around. And by partnering an allele-specific inhibitor where you might be able to inhibit it a little more potently and irreversibly with a pan-KRAS, you may solve some of these problems at the therapeutic window. You can imagine KRAS is so important for so many different cells in your body that if you potently inhibit all KRAS in your body, bad things are likely to happen somewhere. But if you can potently inhibit the mutant allele and then dampen the other KRAS signaling that's popping up, it's more hopeful. Dr. Benjamin Neel: There is a mouse model study from Mariano Barbacid's lab, which suggests that postnatal, KRAS at least, complete inhibition is doable. So, you could take out KRAS postnatally and the mice are okay. Whether that translates to human of course, is not at all clear. And you still have the other RAS alleles, the HRAS, the NRAS that you'd still have to contend with. Dr. John Heymach: Yeah, it's an interesting lesson. We've shied away from a lot of targets we thought weren't feasible. I did a lot of my training with Judah Folkman who pioneered targeting angiogenesis. And I remember hearing this idea of blocking new blood vessels. I said, "Well, everyone is just going to have a heart attack and die." And it turns out you can do it. You have to do it carefully, and in the right way but you can separate malignant or oncogenic signaling from normal signaling in an adult, pretty reasonably in a lot of cases where you don't think you could. Dr. Vamsidhar Velcheti: All right. So, Dr. Neel, and Dr. Heymach, any final closing comments on the field of RAS-targeted therapies, you know, what can we hope for? What can patients hope for, let's say five years from now, what are we looking at? Dr. John Heymach: Well, I'll give my thoughts I guess first, from a clinical perspective, I think we're already seeing the outlines of an absolute explosion in targeting KRAS over the next five years. And I think there's a really good likelihood that this is going to be the major place where we see progress, at least in lung cancer, over these next five years. It's an example of a problem that just seemed insolvable for so long, and here I really want to acknowledge the sustained support for clinical research and laboratory research focused around RAS. You know, the NCI had specific RAS initiatives and we've had big team grants for KRAS, and it shows you it's worth these large-scale efforts because you never know when that breakthrough is going to happen. But sometimes it just takes, you know, opening that door a little bit and everybody can start rushing through. Well, I think for KRAS, the door has been opened and everybody is rushing through at a frantic rate right now. So, it's really exciting, and stay tuned. I think the landscape of RAS-targeting is going to look completely different five years from now. Dr. Benjamin Neel: So, I agree that the landscape will definitely look different five years from now, because it's reflective of stuff that's been in process for the last five years. And it takes about that long to come through. I want to make two comments; one of which is to slightly disagree with my friend, John, about these big initiatives. And I would point out that this RAS breakthrough did not come from a big initiative, it came from one scientist thinking about a problem uniquely in a different way. We need a basic science breakthrough, it almost always comes from a single lab person, thinking about a problem, often in isolation, in his own group. What big initiatives can help with is engineering problems. Once you've opened the door, and you want to know what the best way is to get around the house, then maybe big initiatives help. But I do think that there's been too much focus on the big team initiative and not enough on the individual scientists who often promote the breakthrough. And then in terms of where I see the field going, what I'd really like to see, and I think in some pharmaceutical companies and biotechs, you're seeing this now, and also in academia, but maybe not enough, is that sort of breaking down of the silos between immunotherapy and targeting therapy. Because I agree with what John said, is that targeted therapy, is just sophisticated debulking. If we want to really make progress-- and on the other hand, immunotherapy people don't seem to, you know, often recognize that these oncogenic mutations in the tumor actually affect the immune system. So, I think what we need is a unification of these two semi-disparate areas of therapeutics in a more fulsome haul and that will advance things much quicker. Dr. Vamsidhar Velcheti: Thank you both, Dr. Neel and Dr. Heymach, for sharing all your valuable insights with us today on the ASCO Daily News podcast. We really appreciate it. Thank you so much. Dr. John Heymach: Thanks for asking us. Dr. Benjamin Neel: It's been great having us. Dr. Vamsidhar Velcheti: And thank you all to our listeners, and thanks for joining us today. If you value our insights that you hear on the ASCO Daily News podcast, please take a moment to rate, review and subscribe. Disclaimer: The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy, should not be construed as an ASCO endorsement. Follow today's speakers: Dr. Vamsi Velcheti @VamsiVelcheti Dr. Benjamin Neel @DrBenNeel Dr. John Heymach Want more related content? Listen to our podcast on novel therapies in lung cancer. Advances in Lung Cancer at ASCO 2022 Follow ASCO on social media: @ASCO on Twitter ASCO on Facebook ASCO on LinkedIn Disclosures: Dr. Vamsi Velcheti: Honoraria: Honoraria Consulting or Advisory Role: Bristol-Myers Squibb, Merck, Foundation Medicine, AstraZeneca/MedImmune, Novartis, Lilly, EMD Serono, GSK, Amgen Research Funding (Inst.): Genentech, Trovagene, Eisai, OncoPlex Diagnostics, Alkermes, NantOmics, Genoptix, Altor BioScience, Merck, Bristol-Myers Squibb, Atreca, Heat Biologics, Leap Therapeutics, RSIP Vision, GlaxoSmithKline Dr. Benjamin Neel: None disclosed Dr. John Heymach: None disclosed

medicine rev scientists fda targeting map advances sos pd emt tumors atp merck checkpoint altered ras checkmate ret new england journal novartis lung cancer cancer care gsk precision medicine neel asco genentech bristol myers squibb aegean mtor md anderson cancer center kevan pfs egfr kras alk nyu langone health nci mek gtp nyu grossman school braf eisai novel therapies egf emd serono foundation medicine hras g13 nras pi3 tead t790m transcript dr thoracic oncology program genoptix astrazeneca medimmune

How the United States, G13 Are Meddling in Guatemala

Impunity Observer

Play Episode Listen Later Mar 24, 2022 30:53

Foreign organizations are heavily involved in Guatemala's internal affairs. Nicholas Virzi explains how the US State Department, a member of the G13, is one of the most influential, aggressive, and dominant of the bunch. Virzi's concern is that foreign intervention is counterproductive, since it impedes economic development and stability. Show notes: https://impunityobserver.com/2022/03/24/how-the-united-states-g13-are-meddling-in-guatemala/

united states guatemala foreign us state department meddling g13 virzi

M1 Ultra — How Apple DESTROYED Nvidia

Rene Ritchie

Play Episode Listen Later Mar 11, 2022 12:23

apple iphone mac stem ipads nvidia destroyed usb gb brainstorm thunderbolt m1 ultra prores hevc g13

Episode 69 (nice): Gas Breath/G13 with Isaac and Popo stories

Good Budz Podcast

Play Episode Listen Later Feb 14, 2022 83:02

CHECK OUT! https://www.luminspot.com/?ref=q0XMNkeR5Pf0U . USE CODE "GOODBUDZPODCAST" AT CHECKOUT FOR 50% OFF YOUR ORDER. FREE SHIPPING. CHECK IT OUT!!! MYHIGHSHOP.COM USE CODE "GOODBUDZKURTIS" FOR 35% OFF YOUR ORDER. SHOP NOW!!! Hey budz! In this episode we smoke Mezcal and Ancient Kush and have some Gas Breath and G13 and have some interesting conversession with Isaac about weird Po Po encounters! Check us out and don't forget to like, comment, and subscribe wherever it's applicable! Links below for ya budz! Anchor @ https://anchor.fm/good-budz Good Budz Ghostcast @ https://anchor.fm/good-budz-ghostcast Facebook @ https://www.facebook.com/Good-Budz-Podcast Instagram @ https://www.instagram.com/goodbudzpodcast/ Youtube @ https://www.youtube.com/channel/UChO7zsT943YydhXwY3pD0Fg Twitter @ https://twitter.com/BudzPodcast Spotify @ https://open.spotify.com/show/3Yz7LYoutSGKYNFLNKEqrL Breaker @ https://www.breaker.audio/good-budz-podcast CastBox @ https://castbox.fm/channel/id3213655?country=us PocketCasts @ https://pca.st/8ssqlmgd Patreon @ https://www.patreon.com/GoodBudzPodcast --- Support this podcast: https://podcasters.spotify.com/pod/show/good-budz/support

stories anchor breath checkout mezcal popo shop now off your order g13

M1 Pro & Max — Apple's Intel-Crushing Silicon Explained!

Rene Ritchie

Play Episode Listen Later Dec 6, 2021 23:43

How are M1 Pro & M1 Max so fast?!☎️ SAVE on your phone bill with http://rene.ting.com and get a $25 credit!2 Icestorm high efficiency cores. Up to 8 firestorm high performance cores. Up to 32 G13 graphics cores. 16 Neural Engine cores. With up to 64 GB of unified memory and 400Gbps bandwidth to keep it all fed. A new display engined not just to drive XDR displays, but multiple XDR displays, a third thunderbolt and USB controller for more I/O, a new media engine for super fast, ultra efficient H.264, HEVC, and ProRes encode/decode. Up to 57 billion transistors. And maybe, just maybe, our first glimpse at what's coming next for the iMac Pro and full-on Mac Pro. These are the M1 Pro & M1 Max, Apple's new MacBook Pro silicon, explained!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

apple iphone mac ipads intel crushing io usb gb macbook pro silicon mac pro ice storm imac pro xdr prores hevc g13

Episode 132: DOOM CHAPTER 4 CHARACTERS COMING, More Gear Coming?, Omega Red Skippable?, Deathstrike Event & more

ValleyFlyin Smashin' Time

Play Episode Listen Later Oct 29, 2021 45:19

Dark Dimension 5 Requirements 00:45Planning for Dark Dimension 01:53First to finish and community rewards 08:23Dormammu Kit reveal reaction 10:32Lady Deathstrike Event Positives 14:07Mini Candy Store Choices 16:09Sharon Carter now Farmable 21:08Sharon Initially Missing from Raid Orb 22:50Omega Red Next Week- are you ready? 25:34Omega Red Useful outside of War? 28:30Facebook Poll for AV or Moondragon 30:26Doom Chapter 4 coming next update 33:46Who Becomes Farmable in Doom 4? 34:15G15 pieces in Doom ch4? 36:22Invisible Woman Back! Any Viability? 38:18When will G13 uniques become farmable? 39:00Eternals Coming Next Update? 40:52Wrapping Up 43:49See more MrHartgrave at:https://www.youtube.com/channel/UCSzAn0rWf3Bi4mtAUiFNePA https://www.twitch.tv/mrhartgraveGet up to 20% off your in-game purchases with Amazon coins:https://amzn.to/2SQvQop#MarvelStrikeForceValleyFlyin76 Channel (Marvel Future Revolution) http://bit.ly/2oHqk8EOther Sponsors:LD Player: https://bit.ly/LDPMFRBluestacks 5: http://bit.ly/VFBlueCBD from POP Colorado 10% Discount: https://popcolorado.com/?valleyflyin=3LOOTCAKES Rewards: https://lootcakes.com/register/step1/...SKILLSHARE Premium Free Trial: https://skl.sh/valleyflyin10211 Worldwide Nutrition 15% Discount: https://worldwidenutrition.com/pages/...More ValleyFlyin:Valleyflyin Merch: http://bit.ly/VFMerchDiscord: http://bit.ly/valleyflyinTwitter: https://twitter.com/valleyflyinInstagram: https://www.instagram.com/valleyflyin/Facebook: https://www.facebook.com/Valleyflyin/Twitch: http://bit.ly/vftwitchPatreon: http://bit.ly/VFPatreonSupport the show (http://bit.ly/VFPatreon)

amazon war event doom characters gear discounts requirements av omega red dark dimension g13 moondragon deathstrike

Ariel Alegre - Begeistring - Begeistret for Gud

Pinsekirken Tabernaklet Bergen

Play Episode Listen Later Jun 13, 2021 36:52

Ariel Alegre, administrativ leder i PTB deler videre i Pinsekirkens taleserie om begeistring på G13 gudstjeneste 13. juni.

alegre ptb g13

240: Data Discs and Bad Batch

Shattered Order Podcast

Play Episode Listen Later Apr 5, 2021 98:38

Shattered Order Podcast episode 240 is sponsored by Manscaped! Use promo code "SOP" at www.manscaped.com for 20% off and free shipping! Hosts Dan, GoodNightPunk, 784-346-715, @GoodNightPunk#8529 Wink, WinKILLERinc, 272-797-521, @Wink#2895 Support Links Join our Discord: https://discord.me/shatteredorder Join us on Twitch! https://www.twitch.tv/shatteredorder Twitter: www.twitter.com/shatteredorder Support us on Patreon! www.patreon.com/shatteredorder Bonfire Store: www.bonfire.com/store/shatteredorder Audible Affiliate Link: www.audibletrial.com/shatteredorder http://crew.bluemic.com/SOPod Show Notes Intro The Firepit Podcast: http://firepit.podbean.com Winner of Blue Microphones Giveaway Last Week - Kyzer Asked about which of the Sith Triumvirate to gear to G13 first. What did you do in SWGOH this week? Conquest Update https://forums.galaxy-of-heroes.starwars.ea.com/discussion/243198/conquest-update Conquest Data Disk Planning Bad Batch Update https://forums.galaxy-of-heroes.starwars.ea.com/discussion/242497 Thank you to our Patrons! JaredT Chickenbottom Supreme Vengence Cam WilliamF TieFighterEspresso Drew Dark Helmet KyZer Noel SigSig Bedor Randy Marsh Azaziel BMZR Kvothe Rooskis WookieeCookie Ben_nz Zsplash Stlbrews Recoyle Tiric Thorn RonPaulBunyan Ringer DrooNutz Spicewood R3S6wasinnocent CFrun02 Mykhal Bluuthe HanPikey Xiazer DarthMauly McMole2

data twitch discord bad batch sop discs g13 swgoh sith triumvirate

“ከም ኤርትራዊያን እዚ ኣብ ህዝቢ ትግራይ ወሪዱ ዘሎ ሕሰም ኣይንቕበሎን’ና ነቲ ህዝቢ ምሳኻ ኣለና ምባል ነዊሕ ጽልኢ ከይፍጠር ዝገብር’ዩ።” ጳውሎስ በዓታ

SBS Tigrinya - ኤስ.ቢ.ኤስ ትግርኛ

Play Episode Listen Later Jan 31, 2021 29:27

ኣብዚ ቕምያት፡ ሰማንያ ዝኾኑ ኣብዝተፈላለዩ ሃገራት ዝነብሩ ምሁራት ኤርትራዊያን ንምትእትታው ኤርትራ ኣብ ሕድሕድ ኲናት ኢትዮጵያ ዝኹንን መግለጺ ኣውጺኦም ኔሮም። ኣቶ ጳውሎስ ተስፋግዮርጊስ (በዓታይ) ሓደ ካብቶም ፈረምቲ ናይቲ መግለጺ ኮይኑ፡ ብዛዕባ እቲ ዝፈረሙሉ መግለጺን ብዛዕባ ኣብ ትግራይ ዝፍጸም ዘሎ ኩነታት መብርሂ ሂቡ ኣሎ።ኣቶ ጳውሎስ በዓታይ፡ ኣብ እዋን ቃልሲ ህዝቢ ኤርትራ ንልዕሊ 15 ዓመታት ማሕበር ረዲኤት ኤርትራ ዝመስረተን ዝመርሐን፡ ድሕሪ ናጽነት ኤርትራ ኣብ ዩኒቨርሲቲ ኣስመራ ዝመሃረ፡ ኣብ ምርቃቕ ቅዋም ኤርትራ እተሳተፈን፡ ካብቶም ብ G13 ተባሂሎም ዝፍለጡ ኣብ መንጎ ፕ/ኢሳያስ ኣፈወርቂን ላዕለዎት መራሕቲ ህዝባዊ ግንባርን ዝተፈጥረ ባእሲ ክዓርቁ ዝፈተኑ’ዩ። ኣብዝተፈላለዩ ዓለምለኻዊ ስራሓት ዝሰርሐ ሰፊሕ ተመኩሮ ዘለዎ ምሁር እዩ።

g13

Goal-Oriented w/ danny G (Episode 102)

Mom's Spaghetti

Play Episode Listen Later Jan 28, 2021 51:01

Episode 102 of the weekly Mom's Spaghetti Podcast with Keith Cohen's favorite new music from the week, along with special guest danny G! All songs can be found on the Spotify or Apple Music playlist "Goal-Oriented" (https://open.spotify.com/playlist/2fThwpQwpfDOgvfQbR340E ~or ~ https://music.apple.com/us/playlist/goal-oriented/pl.u-9N9L1bpsx7rZod9)2:01 way wrong -- danny G, Xuitcasecity4:51 lose my cell phone -- danny G7:44 came through -- danny G11:17 lucky -- danny G13:59 run it -- danny G, Daisha McBride, Hendersin17:03 long live -- danny G, Travie McCoy20:33 reeboks -- danny G23:16 Postmates -- valentina cy24:38 Don't Play -- Anne-Marie, KSI, Digital Farm Animals26:09 Breathe -- Syn Cole, Kaspara28:17 Anxious -- Dennis Lloyd29:36 New Wave -- Bow Anderson30:57 Me & My Friends -- Munn, Jude., Fortune32:38 Here's ur chance -- Damien33:47 Monsters -- All Time Low, Demi Lovato, blackbear35:05 I Just Wannt Be Loved -- JORDY36:28 Lifestyle -- Jason Derulo, Adam Levine, Maroon 537:49 Black Hole -- Griff39:20 Sicko -- CLOVES41:03 Pomegranate -- Kota the Friend42:49 Good Vibes (Za) -- Wale44:09 Sunshine (The Light) -- Fat Joe, DJ Khaled, Amorphous, Rihanna45:34 Touch The Sky -- Kanye West, Lupe Fiasco #tbtOther Playlists on Spotify:2021 Leftovers (all the songs featured in 2021): https://open.spotify.com/playlist/25fHYiRQvl6CYCu2MHFIs3?si=q_5SV4-ZQFeTv181pOu7MAThe Kitchen Sink (all songs ever featured on Mom's Spaghetti): https://open.spotify.com/playlist/4QXGN0pFMSlUHaD1vfw6zk?si=yMTeoP8JTR-ZeT_Iyx23mQ See acast.com/privacy for privacy and opt-out information.

spotify mom apple music leftovers g7 spaghetti demi lovato maroon dj khaled ksi adam levine postmates goal oriented amorphous danny g g13 g11

THINK THEORY RADIO - CANNABIS CHRONICLES - 11.21.20

WCPT 820 AM

Play Episode Listen Later Nov 23, 2020 47:58

It's time for Think Theory Radio's "Cannabis Chronicles" On this episode we discuss the cannabis plant in all it's glory! From it's ancient roots in Central Asia to it's use in modern technology, we delve into some of the most fascinating aspects of this magical herb. Does the story of the Holy Grail come from a Scythian cannabis/milk drink? Can a particular strain of cannabis fight off Covid? Plus the discovery of a 2,400 year old solid gold bong & the mystery of the G13 strain!

covid-19 theory chronicles cannabis holy grail central asia scythians g13

Episode 441 - Roberto Godoi

The Grappling Central Podcast: The biggest names in Brazilian Jiu-Jitsu (BJJ), MMA and Grappling

Play Episode Listen Later Nov 20, 2020 142:27

Roberto Godoi joins the show to talk about training since the 80's and being part of one of Sao Paulo's most heated rivalries with his former partner. He also talks about the guard, self defense, grip fighting and the formation and growth of his team G13.

sao paulo godoi g13

Episode 441: Roberto Godoi

The Grappling Central Podcast: The biggest names in Brazilian Jiu-Jitsu (BJJ), MMA and Grappling

Play Episode Listen Later Nov 20, 2020

Roberto Godoi joins the show to talk about training since the 80’s and being part of one of Sao Paulo’s most heated rivalries with his former partner. He also talks about the guard, self defense, grip fighting and the formation and growth of his team G13. Click “read more” for listening options and show notes! […]

sao paulo godoi g13

Rinse & Repeat (021) • Evalution Guest Mix

Rinse & Repeat Radio

Play Episode Listen Later Jun 30, 2020 59:56

Welcome back to Rinse And Repeat Radio! Episode 21 - For this weeks guest mix, we have my little brother Evalution delivering a 30 minute mix full of his originals & remixes. Evalution is a producer & DJ based out of Tallahassee, FL. He's more well-known for his bass productions & DJ sets, but he put together a special guest mix of house favorites for us in this one. Make sure to subscribe on Apple Podcasts and Mixcloud to stay up to date with future episodes!** Evalution Guest Mix Tracklisting **1.) Raffa - How We Do Covid19 (Loudfi Edit)2.) Gawp - Moon3.) M.I.A. - Paper Planes (Evalution & Shulman Remix)4.) Don't Blink - Acid House5.) The Sponges - Feelin' Alright6.) Meduza X Fisher - Piece Of Your Heart (Benzi X Wedamnz Vip Edit)7.) Estelle - American Boy (Bleu Clair Remix)8.) Fountains Of Wayne Vs Matroda - Stacy's House (Shulman Edit)9.) The Rolling Stones - Sympathy For The Devil (Evalution Remix)10.) House Of Pain - Jump A Fckkin Round (Ill Phil & Lorenzo Bootleg)11.) Technotronic - Pump Up The Jam (Nightfunk Remix)12.) Matroda - D.A.N.C.I.N.G13.) Gwen Stefani X Chris Lake - Hollaback Girl (Ango Vip Edit)14.) Biscits - Sundown15.) Sumr Camp Vs Riton, Kah-lo - Fake Id Radar (Evalution Edit)16.) Disclosure Vs Sqwad - When A Street Light Starts To Burn (Evalution Edit)17.) Channel Tres - Controller (Walker & Royce Remix)18.) Tynan Vs Kendrick Lamar - Diggid Swimming Pools (Evalution Edit)19.) Nirvana - Lithium (Evalution Remix)20.) Evalution - ID** Cazes Mix Tracklisting ** 1.) Diplo, Paul Woodford, & Kareen Lomax - Looking At You2.) Tensanke, Fiora - Automatic (The Aston Shuffle Remix)3.) Anabel Englund - Said The Sky (Joel Corry Remix)4.) Eden Prince - Let It Go5.) AFTC - U Got Me6.) Kenny Brian & Gregor Salto - Jaleo7.) ASDEK - Calabria8.) Kaskade & Chemical Surf - Pow Pow Pow9.) Leandro Da Silva & Dario Trapani - Because of You10.) Duke Dumont ft Say Lou Lou - NightCrawler (Illyus & Barrientos Remix)If you enjoyed the episode reach out to me on my socials @cazesthedj and let me know!www.cazesthedj.comFollow Rinse & Repeat Radio on IG for future guest mixes, tracklists, and more!@rinseandrepeatradioUpcoming July Guest Mixes : 7/8 - Los Padres7/15 - Beach Boys (Justin Nyce & Dominic Parisi)7/22 - Danny Quest7/29 - SH8K

dj tallahassee florida diplo rinse mixcloud kaskade duke dumont leandro da silva kah hmc cazes g13 royce remix evalution rinse & repeat radio

45: #OpenMat com Carina Santi

Jiu-Jitsu in Frames

Play Episode Listen Later Jun 26, 2020 82:15

Fala galera, como estamos? Chegamos a mais uma edição do Open Mat e a convidada dessa semana é a Carina Santi, faixa preta da G13. Falamos muito sobre o início dela no jiu-jitsu, a escolha da equipe, viver de jiu-jitsu... Tem coisa pra caramba. Depois me conta o que acharam, fechou? Até a próxima! Para quem quiser assistir no YouTube, também está disponível por lá. Segue aí onde você preferir: https://linktr.ee/jiujitsuinframes (https://www.youtube.com/redirect?v=O3uPU3ZXx4U&event=video_description&redir_token=UnLQsOxTs6g6P9g0HXYeUHAHcx58MTU5MzIxMjM5N0AxNTkzMTI1OTk3&q=https%3A%2F%2Flinktr.ee%2Fjiujitsuinframes) E não esquece de seguir a gente no Instagram também: https://www.instagram.com/jiujitsuinf (https://www.youtube.com/redirect?v=O3uPU3ZXx4U&event=video_description&redir_token=UnLQsOxTs6g6P9g0HXYeUHAHcx58MTU5MzIxMjM5N0AxNTkzMTI1OTk3&q=https%3A%2F%2Fwww.instagram.com%2Fjiujitsuinframes) rames

depois tem fala falamos segue chegamos santi g13

I NEED R3HAB 389

R3HAB – I NEED R3HAB

Play Episode Listen Later Mar 16, 2020 60:03

1.R3hab & Vini Vici - Alive (Cat Dealers Remix)2.R3HAB & Icona Pop - This Is How We Party3.Tchami 'Proud' ft. Daecolm4.Wongo 'D.A.D. (Dance All Day)'5.Dubdogz & Bhaskar - Infinity (NEUBAUER Remix)6.BYOR - Don't Stop The Disco (Extended mix)7.Lucas & Steve x Brandy - I Could Be Wrong (Kim Kaey Remix)8.R3HAB, ZAYN feat. Jungleboi - Flames (R3HAB & Skytech Remix) [Radio edit]9.Robin Schulz Feat Alida - In Your Eyes (KREAM Remix)10.We Are Loud feat. Katie DiCicco - On The Run (Extended Mix)11.R3HAB - BAD!12.Matroda - D.A.N.C.I.N.G13.R3HAB & A Touch Of Class - Around The World (La La La)14.SWACQ - Horny Horns [Extended Mix]15.Riggi & Piros x Dave Crusher & JackMar - Good Time (Extended Mix)16.Firebeatz - Bad Habit17.BROHUG - Say My Name18.NF - I'm Back

dance mix radio show edm r3hab lucas steve we are loud riggi piros g13 r3hab bad

S3, E1

ATLiens United

Play Episode Listen Later Feb 13, 2020 55:58

Players we lost:Andrew Carleton (on loan to Indy Eleven)Dion Peirera LGP (was 5th highest paid player on our team)In moving LGP(110) and Gressel (115), AU has now moved it two all-time appearance leaders -New club - Club Tijuana of Liga MXPogba Gressel AU acquired up to 1.1 Million in allocation money (S650k TAM in 2020 and $100k in 2021 - we can receive additional $350 TAM if he performsParkhurstJustin Meram - Salary too high for us to renewVasquezSuperdraft pick up from Nashville (traded to Cincinnati FC)Nagbe - traded to Columbus for $700,000 in Targeted Allocation Money, $150,000 in General Allocation Money and an international roster spot for the 2020 MLS season - The Crew will also pay Atlanta $200,000 in TAM for the 2021 MLS season and should Nagbe meet certain performance conditionsTito - wanted a guarantee for more playing time.Sold to Club Libertab (for reportedly 1.5 to 2 million)Mikey Ambrose (we didn't renew his contract and he was picked up by Miami)Inter Miami about to sign Pizarro from Monterrey He would join the onslaught of Liga MX players joining MLS this year.CBA Negotiations are done. Noteworthy changes below:Free agency age lowered (from 28 to 24 with 5 years of play)Senior player minimums increased to 109KDP rule changed slightly (2 unlimited $$, 1 only unlimited $$ if player is under 23 - making sure MLS is seen as a selling league as oppose to retirement league)Better player health and working conditions 401K increase to 4.25%Charter flight increase (mandatory 8 flights this year, increase to 16 by 2024)Increased travel per diemWe have a new sleeve sponsor - Piedmont HealthcareNew white and gold away jersey released - thoughts? (by the way, AU is the symbol for gold on the periodic table)Rumours of a third kit to high performing teams (aka Atlanta United) via The Athletic for next year. I would take a third kit.MLS in 90 Seconds:People who have left the league:ZlatanMinnesota boldly decided to dump their whole team and start over.Austin FC gets first jersey sponsor (Yeti)Zimmerman was traded from LAFC to Nashville for 1.25 Mil in allocation money (right before CCL too, ouch)Nashville is at a standstill with their mayor as he refused to move forward with the promised Nashville FC stadium. This is bad for the league, everyone should sign the petitionBWP is staying in the MLS and playing for LAFCNYCFC’s CCL game moved to Red Bull Arena (they are close to securing their own stadium in the Bronx)Inter Milan is suing MLS for trademark infringement, claiming that the term “Inter” is synonymous with its club and no one else. Inter Miami lost a key battle in the fight to keep its name which says the U.S. Patent and Trademark Office (USPTO) dismissed one of the MLS club’s two arguments.MLS will appeal the decision, and likely lose. - Probably change their name to Flamingo and get sued by Brasil.Columbus made some good moves with Nagbe, Lucas Zelarayan and Vito Wormoor (NED)LAFC is still the team to beat. Virtually same roster plus new weapons like Uruguay U23 Francisco Ginella, Brian rod, Diego Palacios.Injury Report:Bello is going to be fine- head injury is not as serious as they originally thought and he should be back on the field playing relatively soonMiles Robinson was taking off early against Leones Negros - quad strain, hopefully back by CCL Beer of the Week:Sweetwater’s 23rd Anniversary Ale (foeder-aged sour IPA)“We are celebrating our 23rd anniversary by marrying two of our favorite styles featuring an out of this world dry hop. Notes of pineapple and tropical fruit dominate this light to medium bodied ale fit for every occasion. Strain Inane OG (mexican-style craft lager)Limited release (flowing starts Feb 2020), 5.6Sweetwater Events:DATE: Saturday, February 15thTIME: 2:00pm - 10:00pm at the breweryThey are giving away custom 420 and G13 skis at the party!A Full day of music featuring:- Arrested Development- B-Real- DumpstaphunkBEER: A fat stash of draft options from our cellar, a boatload of specialty brews, and all the weirdest and wildest from The Woodlands barrel aging facility.Debut of our 23rd Anniversary Ale, a foeder-aged sour IPA.FOOD: Our brand spankin new taproom will be open with a special Anniversary Party-perfect menu.And a bevy of food trucks featuring tasty options.TWO WAYS TO PARTY:General Admission: $19Enjoy all the music, buy the brews and food you want, and hang out all damn daySuper Heady VIP: $694 complimentary brewsPrimo viewing area for all the showsVIP restrooms & barDedicated VIP gate with unlimited re-entry' __________________________________________________Second Self Events: (pick two things to cover this week)Every Tuesday - $3Year Round Pints (Thai Wheat, ATaLe, Golden Blonde, Mole Porter, viKings of the South)Feb 14th: Valentine’s Dinner Pairing with Chef Telene (A multi-course menu playing homage to the love and diverse food culture available in West Midtown. Every course will be perfectly paired with a Second Self beer. Tickets are $65 per person. Limited spots available!) AND Bleeding Hearts Art Show_________________________________________________Steady Hand Events:FIRST Anniversary Party on 3/7 - mark your calendars NOWOffseason RecapFranco, Barco and Remedi have become permanent residents and no longer take up an international roster spotGuz has signed a contract extension through 2023 Players we’ve gained:Anton Walkes (Portsmouth) (age 22) (British)Adam Jahn (Transferred from Phoenix Rising FC - forward) (age 29)Brooks Lennon (came from RSL) (age 22) (American, yet to make the senior national team)Matheus Rossetto23 year old BrazilianComing from Club Atletico Paranaense (PR)Attacking midfielder (Nagbe replacement?)Edgar Castillo (defender, american, age 33)Castillo is an attacking left back - Castillo originally came to MLS in 2018 after winning multiple titles in Liga MX with Santos Laguna and TijuanaFernando MezaThe 29-year-old Argentine, who came up through the San Lorenzo ranks in his homeland, where he was teammates with Five Stripes winger Tito Villalba, is in his second stint with Necaxa with a stint at Chile’s Colo-Colo sandwiched between in more than a decade of professional experience.Jake Mulraney (age 23, irish, transfer from Scottish Premiership side Heart of Midlothian,64 appearances for Inverness over the course of two seasons, collecting three goals and six assists. In 52 appearances with Hearts, the 23-year-old had two goals and 10 assists.Luis Manuel Castro Uruguayan winger Manuel Castro on loan from Club Estudiantes de La Plata of Argentina’s Primera División. The loan will last through the end of June with a club option to extend to the end of the calendar year. Castro will occupy an international roster slot and will be added to the roster pending the receipt of his International Transfer CertificateSpike the dogTactics/CCL PreviewBest matchup: Leon vs LAFCPick a final 4: Tigres vs Sounders, Leon vs Atlanta United

The Nammy Wams Show - 28 January 2020

Croydon FM

Play Episode Listen Later Jan 29, 2020 120:56

The Nammy Wams Show - 28 January 2020 J43 - J43 KRIMELIFE VIP . 2020TAPE . - Climaks Beats - Brick Terms (Instrumental) Sapphire Beatsz - 042 - G13 -144bpm Wardot - devils hour Jojo Hundred - BWB (Radio Edit) - ghost - maggie sauce 1.0 denx66 - DENZEL X - Organic Flutes Wardot - each war_2 J43 - J43 - KeepPushin . 2020TAPE Poundz - Opp Thot Final Master J43 - J43 X BEXYL , NO GO ZONE 2020TAPE Funky Dee - Run (Instrumental) Skengdo x AM x M24 x Stickz - crash x gbg clean J43 - J43 - W_SANTOVASB . Ocean Blvd , 2020TAPE 1 - WITCH DOCTOR Smuggzyace - OBBO ON ME CLEAN Wojavelli - sarto - POUNDSHOP - DEEP VEIN (OLIVER TWIST REMIX) Wojavelli - bjork love dub - HEXAGON GENO X SKOLZ X MUNROE - JEB1 - Thats It 150bpm - J43 - Midnyt Club SS - POUNDSHOP-D'ACCORDION Sapphire Beatsz - "CHINA CHINGINS" - USB C TO USB A - FIRST CIRCLE DEMO - LOOSE 1 X KAVELLY - SHOTTAZ (PROD. BY D PROFFIT) J43 - J43 - ULTRAVIOLET 2020TAPE Sapphire Beatsz - ladidah drill 143 J43 - J43 . ALL4YU . 2 PLANET TANTRA , 2020TAPE - POUNDSHOP - WICKER MAN Gotti On Em/Mikabeats - 2. Percocet #SilwoodNation T1 X A Miz - Juventus RADIO CARNS HILL - BLADE BROWN NOBODY PERFECT INSTRUMENTAL Just Banco - The Walking Dead RADIO J43 - J43 w_ DXVL . RideOut . 2020TAPE 1 - ALEX, FRIDGE - UNKNOWN CALLER (TAGGED) KID D - SET FIRE (SYYMZ EDIT) Kid D - Take Me Away (Radio Edit) GottiOnEm - SEVAQK X GOTTI X MKTHEPLUG X 3DAMIND 002 (1) - @BKAYPRODUCER - SWEATER Skengdo & A.M, Sneakbo - Brixton Boy MKTHEPLUG - SHORE - 1_4 final - roll-up_899620 - P WAVE - ABSURD Firaasbeats - Daytona Smoove'L - Palm Angels Pop Smoke - Christopher Walking #SilwoodNation T1 - T's Up AB - Unmuted Richi (Mali Strip) - Blocka Dutchavelli - Only If You New Tayfun - Stuck In The Trap DigDat - Pcx (feat. Headie One) #7th Yanko X Y.CB X #CGE MA - No Hook 67 - Way Before UDN Youngs Teflon - Dillian Whyte DigDat - Untitled (feat. Frosty) TPL (Jojo x O'mizz x TD) - Philly Don't Dance M1llionz - HDC Casanova Fivio Foreign Smoove L - Demons & Devils BOSSMAN HORSE - DYING TOGETHER ST 67 - Full Wass (Gherbo Never Cared Remix) Grubb0 - PB (Prod. By LoLife) #Exclusive Sxxnba - DAY TO DAY M Huncho - Pee Pee Nafe Smallz x Yxng Bane x Blade Brown x Skrapz - Faith In My Killy J Hus - Repeat (feat. Koffee) J Hus - Helicopter (feat. iceÃ¨ tgm) J Hus - Fight for Your Right Rush - Trapper N Scammers RemDuece - Shootouts Lights ft. Tiny Boost & Kaos - Don't Try Me Robbahollow - Money Motivated (feat. Traumz) POUNDSHOP - ONE SEVEN (FT.DON SININI) Juj'd Up Jim - Hard For This M Huncho - Indulge (feat. D-Block Europe) M Huncho - Bando Ballads K Trap - Paid The Cost cB x Baseman - Still Wavin #410 JaySlapIt X #TOG Wreckit X Striker - No Love (CGE) Young Stacks X MA - Routine #LTH MA x C1 - Wrey and Nephew Yxng Bane - Gang Shit #SinSquad Mloose X LR - Dont Ride Back #SeriousSteppers #OFB Izzpot - Free S Meekz - 6 Figures #98s Hitman x DA - Smoke #OFB Kush X Double Lz - No games G4 Boyz - Local Scammer (feat. G4choppa) OT Chi - PLT Nito NB - Love Island M24 - DANCE WITH SMOKE Kwengface X Karma - Lemme Get A Lighter #CGM Digga D x Sav'O x M'Skum x TY x Rack5 x Striker x Horrid1 x Dodgy x Splasha - 10+1 C Block - Trap Kid 2.0 #SilwoodNation T1 X C9 - Like Jordan cB - The Things K Don - Ko Lee Noodles DBF Win - FaceTime Skeamer - War Ready

figures hitman striker dodgy rideout headie one yxng bane g13 wams blade brown nammy tiny boost

Episode 15- SweetWater 420 Strain G13 IPA and Modifying Art

Drep and Stone

Play Episode Listen Later Jan 8, 2020 46:08

Kyle and Nick sample SweetWater Brewing Company's 420 Strain G13 IPA while discussing when it's appropriate, if ever, to modify a work of art. We'd love to hear from you! Email us your comments and questions: DrepandStone@gmail.com and connect with us via Instagram, Facebook, Twitter, or DrepandStone.com Don't forget to subscribe! Music by @joakimkarudmusic

music art sweetwater modifying g13 sweetwater brewing company strain g13 ipa

The Nammy Wams Show - 10 December 2019

Croydon FM

Play Episode Listen Later Dec 11, 2019 121:06

The Nammy Wams Show - 10 December 2019 J43 - Soul Society Sapphire Beatsz - "CHINA CHINGINS" - Christmas Special [Prod. By TRS] wav Yamaica Productions - ''My Guys'' (Prod.by.Yamaica) - Poundz - Opp Thot Final Master (Clean) - J43 - Midnyt Club SS Vader Beatz - 5AM Sapphire Beatsz - lil tramp 143 Sustrapperazzi - Lucki Silwood Nation (A Miz x N.A) - Limited Faith (Prod. By ZVK) CLEAN - J43- Nu Beginings - POUNDSHOP - WICKER MAN Rushy - Pretty Face (Feat. Lano) - Clean - gottionem x jb - kwef that Gotti On Em - wardot gotti ep 2 - GottiOnEm x Mikabeats - Lurking Smuggzyace - OBBO ON ME CLEAN Dot Rotten - Pirate Radio Paradise - PRINGLES RADIO EDIT SlickJay - 67 x 86 Type Beat _ iLLEAGAL _ _ @SlickJayBeatz _ 2016 5TARB01 - 5_X Yamaica Productions - "Woah" - J43 KrimeLife SS - felix lee x nammy wams Sapphire Beatsz - 042 - G13 -144bpm Sapphire Beatsz - kodak karma 145 - UNTITLED (ANTACID) - FIRST CIRCLE SYYMZ - UNKNWN HARP 2 Jojo Hundred - BWB (Radio Edit) Ozyenia - uni1 Craftadicts - "Scary Sight" MMoney - MMoney Scatter Anthem Demo - FUSION - TheyLoveCookn x MadaraBeatz - SD - Inastagram Live QUIETPVCK - DIG DAT X BT - FLING IT_2 - JEB1 - Bongo Drill Grime MIKabeats - NewAgeDrill Wardot - riskmas_2 - J43 Trapan _ 2K EXC GottiOnEm - glider Teeza - Mass Murder (Instrumental) Vader Beatz - 3UP Vendetta Productions - VENDETTA x GHOST - GRITS BOP - 25066_LZ-Reload-PRODSOTTVII-x-CHUBZTP - gotti sapph sykes drill - lauky beatz The New PLUG #ShellDown Series - ice kid- sub zero[instrumental] - tragic prod by kayman x mika SmuggzyAce x Latts - Real Drillas (Zone 2 X HitSquad) Kwengface X PS - BarToon Network Freestyle (Back2Back) Fizzler x Kwengface - Algebra M24 - DANCE WITH SMOKE Trapx10 - Hugh Hefner #OFB Lowkey - Playtime Done Dot Rotten - Land of the Brave Richi - Oh Please (Malistrip) Kwengface X Karma - Lemme Get A Lighter #410 Sparkz X Blackz X Yamz - Rise That Up T Face x Racks X Sav - Triggered #HarlemO SD x Splash x Slay Products - K?s and O?s #CGM Digga D x Sav'O x M'Skum x TY x Rack5 x Striker x Horrid1 x Dodgy x Splasha - 10+1 Karma - Working (feat. Kwengface) #OFB Dezzie - Bad Breed Teeway - Statements Mars x Mizz - Bitcoin Livin' #MHG S1 - Pirate Swing #SilwoodNation T1 X C9 X Amizz - Â¥ing Dat GeeYou Ft. Young Adz - Push Weight Lancey Foux - Psykeman Lancey Foux - Elon Musk Carns Hill, trizzac (zone 2) - Like Me Headie One - Secure the Bag (feat. M Huncho) ST 67 - Full Wass (Gherbo Never Cared Remix) #SilwoodNation T1 X C9 - Like Jordan Lancey Foux - Dead & Gone K Don - Manouevre Dr Vades, Burna Boy, K-Trap - Deja-vu Blade Brown feat. Knucks - Harrods Tommy Hill - She Says Country Dons - Sticky Situations Tunde - Wacky Racers 38 x Alz (YMN) - THE HOTSPOT J Fado - Elevate Kwengface - Sonic 2 Abra Cadabra - Remember Me? P Wave NFR - Absurd (Prod By Mubz Got Beatz) Lancey Foux - So Free Carns Hill, Scribz, SJ - Canadian Fur Carns Hill, V9 - Spinners M1llionz - No Rap Cap Vybz Kartel Ft. Sheba - Like Xmas

splash bag striker dodgy burna boy g13 wams nammy

It's on Fire

Cantina Vizsla: A Star Wars Galaxy of Heroes Podcast

Play Episode Listen Later Jul 15, 2019 89:44

It’s all on Fire. Join us this week as we discuss how we are planning to take on GAC and the Geo TB. How many teams do you need? What type of gear? Who needs that zeta? For GAC how are we making out and how much is G13 starting to make a difference. And as always Thanks for listening! Discord Channel: https://discord.gg/TDn5Kcd Contact us at cantinaviszla@gmail.com or on discord at Sparrow#5965 or Stan {Cantina Vizsla}#3492

fire sparrow gac discord channel g13

Solo: A Stan Wars Story

Cantina Vizsla: A Star Wars Galaxy of Heroes Podcast

Play Episode Listen Later Jul 6, 2019 40:15

Sparrow is on vacation, leaving a confused, angry old man alone with the Internet. In this "Expanded Universe" episode, Stan gives his initial thoughts on G13 and the Geonosian Territory Battle, announces the winner of the Mandalorian Poster drawing and waxes philosophical on Vader Immortal, Endgame re-release, and Stranger Things Season 3! And as always Thanks for listening! Discord Channel: https://discord.gg/TDn5Kcd Contact us at cantinaviszla@gmail.com or on discord at Sparrow#5965 or Stan {Cantina Vizsla}#3492

internet solo wars endgame sparrow stranger things season expanded universe discord channel vader immortal g13

Ep. 22- Lucky Number G13, Nute Rocks and Why CG Needs to Hire Us

Holotable News Network: A SWGOH Podcast

Play Episode Listen Later May 30, 2019 86:26

After a slow 4 weeks in the game, we discuss the developer Q&A with some new ship hints and the impending arrival of G13. We also discuss lots of possibilities for the new Grand Arena and TB map setups. In other big news, SirGeorgeous has an awesome new Nute team and looks to be a lot more active on YouTube this summer. Enjoy!

rocks tb lucky numbers hire us g13 nute grand arena

Peanut Butter and Nortons

Trench Bros Podcast

Play Episode Listen Later Apr 25, 2019 70:51

Beers Reviewed: 1. Sweet Water 420 strain G13 2. Stone Ruination DIPA 2.0 3. Sweetwater 420 strain Mango Kush Wheat Ale 4. Martens Boot Tread 5. Free State Barleywine Ale 6. Norton's Brewing Polkadot Princess 7. Norton's Brewing Nobody Puts Baby in A Corner

corner peanut butter sweetwater g13 nortons beers reviewed

Christian's Dyin' Y'all

The Atlanta Podcast

Play Episode Listen Later Mar 11, 2019 70:34

In this episode, the guys tough it out through Christian's shitty and annoying cough to talk about the shift in gun control funding, superbowl-sized taxes, and some good ol' fashioned Saints hate. #ATLSalute goes to: @atlanta_street_art_map What's On TAP? 420 Strain G13 IPA ABV 6% - Sweetwater Brewing Company This aromatic super-hybrid sticky IPA is first and foremost a phenomenally delicious and drinkable beer, with the added bonus of an olfactory experience that mimics that of the legendary G13 cannabis strain. The IPA base brew has a great body, good head and nice amount of haze at a pleasurable 6% ABV. To work with the malt bill, the brewers added some of their dankest hops, Columbus and Simcoe, plus two dry hop additions. To achieve the aroma, our brewers found the perfect botanically-sourced, strain specific terpenes and married them with propriety natural hemp flavor, both perfectly complementing the hops in the IPA.

saints columbus ipa abv simcoe dyin on tap g13

NEVASAYNEVA SUNDAY'S 3.10.19

BUSHWICK RADIO

Play Episode Listen Later Mar 10, 2019 115:56

BUSHWICK RADIO PLAYLISTMasta Ace Smif n wessunIan Kelly & swankBlu & oh noSean price ft.illla ghee & rockRome Streetz ft.daniel sonDjmuggs ft.eto & willie the kidConway & imported goodzBenny ft. 38speshPlanet Asia ft.ghostface killahBig twin ft.ruste juxxDave east ft.styles pSupreme cerbralPapooseNapoleon da legendP general ft.shatike & skanksMadhattenBill ray ft.sadat xTito briganta Preme m.i.b1. Ain't Gone Do Sh..- Billy Danze2. Powers And Stuff- Czarface, Ghostface3. Joy- The Legion4. Wreck The Mic- Tone Chop, Frost Gamble5. Sweep The Leg- B Boy Mansini, Banish Habitual6. Ocean Drive- Smif N Wessun, Musiq Soulchild, Rapsody7. Refrigerator P- Sean Price, Small Professor8. No Ideas Original remix- Nas9. Alguna- Freddy B, Lord Kaos, Unique, Lega C10.The Game- Aich Willams, Trigger Tha GamblerTALK BREAK11.Music Makes Me High pt 2- Mr Cheeks, Keith Murray12.Don't Mean Nothin- Showbiz, A.G13.County Of Kings- Daddy-O, Fran Lover14.Just In Town- CL Smooth

hip hop unique rap cheeks musiq soulchild preme new hip hop g13

155: G13

Games on Earth

Play Episode Listen Later Dec 14, 2018 59:25

This week we review our great success at extra life and Jesse gives us an overview of the brazen masterwork that is 'The Quiet Man'. Thanks so much to everyone who donated to our extra life event. We ended up raising $2555 FOR THE KIDS! Our biggest year ever! Also the boys start a new podcast within a podcast called G13, all about one star weed reviews! Thanks to Kyle Landstra for the intro/outro music --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app --- Send in a voice message: https://anchor.fm/gamesonearth/message Support this podcast: https://anchor.fm/gamesonearth/support

g13 kyle landstra

19: Good Hair

Scare You To Sleep

Play Episode Listen Later Oct 26, 2018 103:26

From the same author who brought you The Smile.... Down on her luck and depressed, a stranger offers Sarai a chance at rebuilding her life from the ashes. This rich elderly woman is invasive, but what if putting up with her touching her hair means finally being able to live life again? For more from author Nina G. Jones, visit her [Amazon Store](https://www.amazon.com/Nina-G.-Jones/e/B00EQM6CB4/ref=sr_ntt_srch_lnk_1?qid=1540524347&sr=8-1) Visit [HelixSleep.com/SLEEP](https://helixsleep.com/pages/landing-page?promo=sleep) and use my offer code SLEEP for up to $125 off your mattress order! To become a Patreon donor visit [Patreon.com/ScareYouToSleep](https://www.patreon.com/scareyoutosleep) "Decay", "Deep Noise", "Evening of Chaos", "Ossuary 6 - Air", "Shadowlands 3 - Machine", "Tranquility Base" Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 3.0 http://creativecommons.org/licenses/by/3.0/ Car electric window.wav by devy32 https://freesound.org/people/devy32/ Dog bark.grunt.wav by apolloaiello https://freesound.org/people/apolloaiello/ Dog Barking SFX.wav by CameronPheiffer https://freesound.org/people/CameronPheiffer/ RG Large Old Dog Snoring.wav by cmusounddesign https://freesound.org/people/cmusounddesign/ shower.mp3 by geodylabs https://freesound.org/people/geodylabs/ Dog Growl - Beast / Creature by coldvet https://freesound.org/people/coldvet/ RunningDownstairs.wav by mikaelfernstrom https://freesound.org/people/mikaelfernstrom/ rotary phone dial numbers.wav by lwdickens https://freesound.org/people/lwdickens/ gunshot indoors.wav by chris_81 https://freesound.org/people/chris_81/ FOLEY_Footsteps_Laminate_001.wav by conleec https://freesound.org/people/conleec/ Horror; throat cut; close.wav by TylerAM https://freesound.org/people/TylerAM/ Dog Growls by black_trillium https://freesound.org/people/black_trillium/ G13.2-09-Muffled Cars.wav by craigsmith https://freesound.org/people/craigsmith/ Renault Master F3500 dCi135 Exterior Engine Start Up Idle And Drive Away Mono Follow.wav by Soundholder https://freesound.org/people/Soundholder/ Car Accident with Squeal and Crash by HoBoTrails https://freesound.org/people/HoBoTrails/

dogs chaos sleep horror air crash smile car kevin macleod decay shadowlands good hair amazon store squeal ossuary tranquility base g13 deep noise nina g jones

19: Good Hair

Scare You To Sleep

Play Episode Listen Later Oct 26, 2018 101:28

From the same author who brought you The Smile.... Down on her luck and depressed, a stranger offers Sarai a chance at rebuilding her life from the ashes. This rich elderly woman is invasive, but what if putting up with her touching her hair means finally being able to live life again? For more from author Nina G. Jones, visit her [Amazon Store]To become a Patreon donor visit [Patreon.com/ScareYouToSleep](https://www.patreon.com/scareyoutosleep) "Decay", "Deep Noise", "Evening of Chaos", "Ossuary 6 - Air", "Shadowlands 3 - Machine", "Tranquility Base" Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 3.0 http://creativecommons.org/licenses/by/3.0/ Car electric window.wav by devy32 https://freesound.org/people/devy32/ Dog bark.grunt.wav by apolloaiello https://freesound.org/people/apolloaiello/ Dog Barking SFX.wav by CameronPheiffer https://freesound.org/people/CameronPheiffer/ RG Large Old Dog Snoring.wav by cmusounddesign https://freesound.org/people/cmusounddesign/ shower.mp3 by geodylabs https://freesound.org/people/geodylabs/ Dog Growl - Beast / Creature by coldvet https://freesound.org/people/coldvet/ RunningDownstairs.wav by mikaelfernstrom https://freesound.org/people/mikaelfernstrom/ rotary phone dial numbers.wav by lwdickens https://freesound.org/people/lwdickens/ gunshot indoors.wav by chris_81 https://freesound.org/people/chris_81/ FOLEY_Footsteps_Laminate_001.wav by conleec https://freesound.org/people/conleec/ Horror; throat cut; close.wav by TylerAM https://freesound.org/people/TylerAM/ Dog Growls by black_trillium https://freesound.org/people/black_trillium/ G13.2-09-Muffled Cars.wav by craigsmith https://freesound.org/people/craigsmith/ Renault Master F3500 dCi135 Exterior Engine Start Up Idle And Drive Away Mono Follow.wav by Soundholder https://freesound.org/people/Soundholder/ Car Accident with Squeal and Crash by HoBoTrails https://freesound.org/people/HoBoTrails/ Get bonus content on Patreon See acast.com/privacy for privacy and opt-out information.

dogs chaos horror air crash smile car decay shadowlands good hair squeal ossuary g13 deep noise nina g jones

The Cookie Crew, Part 3

Quest Friends!

Play Episode Listen Later Oct 15, 2018 41:38

The crew puts together a plan to pawn off terrible cookies and save a mild acquaintance. Listen as they: SING sweet songs! TUNE into action! ASSURE you that backup is coming, no seriously, we promise! Transcript: https://docs.google.com/document/d/1GR2YZvC79HTkZI7TAYoKC244FQcsjM8urnqKPYjIsTM/edit?usp=sharing Purchase Quest Friends stickers/shirts/posters here: https://www.questfriendspodcast.com/shop Follow our other accounts! Website: https://www.questfriendspodcast.com Patreon: https://www.patreon.com/questfriends Facebook: https://www.facebook.com/QuestFriendsPodcast/ Tumblr: https://questfriendspodcast.tumblr.com Twitch: https://www.twitch.tv/questfriends Twitter: https://twitter.com/Quest_Friends YouTube: https://www.youtube.com/channel/UC62OqSFLVUvqw-a_UaAryKA Music/Sound Effects "Great Fun" by Antarctic: https://audiojungle.net/item/great-fun/8294382 "Western Story" found via Motion Array: https://motionarray.com/stock-music/western-story-25586 "City Jaunt" by Jay Man/OurMusicBox: www.youtube.com/c/ourmusicbox "Lobby Time" by Kevin MacLeod: incompetech.com (Licensed under Creative Commons: By Attribution 3.0 License http://creativecommons.org/licenses/by/3.0/) "Ride the Lighting" found via Motion Array: https://motionarray.com/stock-music/ride-the-lighting "Halloween Heroes" found via Motion Array: https://motionarray.com/stock-music/halloween-heroes "G13.1-22-Old Car on Rough Road.wav" by craigsmith: https://freesound.org/people/craigsmith/sounds/438049/ "Dark Outlaw Rock" by Voidcore: https://motionarray.com/stock-music/dark-outlaw-rock-90202 "Car Engine, Exterior, B.wav" by InspectorJ: https://freesound.org/people/InspectorJ/sounds/345557/ "Engine running w/sounds of rain and wipers (new title test)" by Maurice_J_K: https://freesound.org/people/Maurice_J_K/sounds/353595/ “Village Consort” by Kevin MacLeod: incompetech.com (Licensed under Creative Commons: By Attribution 3.0 License http://creativecommons.org/licenses/by/3.0/) "Goof Music" by Liam Priestnall: https://youtu.be/ZHCCh6fFARc "Road Trip" by SKANDR: https://soundcloud.com/skandrofficial/road-trip

ride sing road trips kevin macleod lighting engine exterior assure inspectorj rough road lobby time g13 village consort maurice j k

To Choose the Wild

Write

Play Episode Listen Later Oct 6, 2018 19:24

Which traveling soul are you? Do you take the road that's already been paved ahead of you or do you take the road less travelled, carving out your path through the wild?

las vegas travel wild write kenya wilderness travellers leopards g13

13: Hannah the Beer Rep

People in My Neighborhood

Play Episode Listen Later Aug 2, 2018

You never hear anyone say, “I wanna be a beer rep when I grow up,” despite most beer reps feeling like they were born for the job. My guest, Hannah Graham is one of those people. Listen to how her journalism dreams got drunk in the best possible way.

beer journalism eagle broadcasting knoxville craft beer sportscenter sweetwater hannah graham g13

TechTonic E25 ‘Sounds From The City' May 2018 Techno Mix

Jockster » TechTonic Podcasts

Play Episode Listen Later May 30, 2018 163:35

1. Directions FT Wevie Stonder-Wevie Stonder/Breton (Cirez D Mix)2. Technologic-Dino Maggiorana3. Point of No Return-Reelon4. Trust Your Soul-Hot Lips Inc. 5. Stratis-Durtysoxx (Alen Millvojevic/Drzneday RMX)6. No Guilt-Yotam Avni7. Calling-DJ Boris/D-Unity8. On My Way-Marco Faraone9. Take Control-Tommy Wada/Dino10. Sundrowler-Ferhat Albatrak11. Celestial-Rustek12. Star-Fatima Haaji (Drunken Kong)13. Stop & Go-Hidden Empire14. Mind Reader-Origin Riddim15. FM Bells-Hot Lipps Inc16. Volataic-Samuel Sessions (Petter B Remix)17. Again Again-Hidden Empire (OC and Verde Mix)18. Clickbait-Mario Ochoa19. Hydra-Kaiserdisco (Aitor Ronda Remix)20. Overtime-Avison21. Phenom-Steve Mulder (Filterheadz Remix)22.Alone FT Ursula Rucker-2Pole23. Maybe-Da Fresh24. Solid Buzz-Inudstralyzer25. Sandworm B-Nikola Gala26. Sorites Paradox-Tomy DeClerque27. Involved-Amy Kello/Kalil28. A42-Gabriel D'or & Bordoy'This is G13' (Outtro) 'American Beauty'

techno american beauty techno mix outtro g13 techtonic bordoy

G33kpod Blue Episode 13:How To Get Arrested At A Theme Park

G33kpod

Play Episode Listen Later Aug 3, 2017 43:50

This episode is G13 classified. Not really. I just wanted to say that because it is episode 13. I'll stop now... Opening theme is: Opportunity by Jamus Breed*Closing Theme is: Bucket by Jamus Breed* Leave us feedback on Itunes, Twitter: @g33kpod or @hugh_g33kpod and Facebook : Facebook.com/g33kpod or via email: contribute@g33kpod.com *Licensed exclusively to G33kpod Network by Dennis Johnston

opportunities arrested bucket theme parks g13 g33kpod

Episode 223, "I call her spider-bird lady"

World of Warcast: A World of Warcraft Podcast

Play Episode Listen Later Nov 30, 2016 57:20

Special guest host Cara (@Xandara) joins us. Got the Star's Design Cara's anniverary present - very limited edition Warcraft novel. Upgrading to a Logitech G600 mouse. What is involved in "relearning" keys and "unlearning" the G13. Muscle memory vs. fast casting. This week's Timewalking is Cataclysm. Blizzard fixed the Suramar AP exploit. Mike finally transferred off Emerald Dream. WoW up to WoD is on sale for $4.99. Cara's raiding experience.

spider muscle blizzard warcraft upgrading cataclysm wod bird lady g13 timewalking cara xandara

GVOZD - PIRATE STATION @ RECORD 26042016

Play Episode Listen Later Apr 26, 2016 119:50

Это ночное приключение с Пиратской Станцией несло вибрации позитива, любви и конечно свежести звука нашей музыки! Перепрыгивая с гребня на гребень волн разных сабжанров, постарался осветить Сцену и еще больше привлечь вас в ряды dnb людей;) Вместе на этом пути?m/ GVOZD vibes 1.Urbandawn - Messiah Complex (Hospital dub) 2.Signal - No Control (Critical) 3.Proxima - Ruff Scuff (Neodigital) 4.Bad Influence - Spice (Cutting Edge sounds) 5.Nicky Blackmarket ,Voltage - Uss Enterprise (Annix remix)(Dub Damage) 6.Jedi - Come Get Some (Audio Overload) 7.mr Quiet and Sym On - Over The Edge (Dub Voltage) 8.Pacso - The Trick (Turno remix) (G13) 9.Telekinesis - Listen (Blackout Music) 10.Segment and Concept Vision - Mammoth (Eatbrain) 11.Okuli - Shift Grip (Mindtech) 12.Calyx and Teebee - Nothing Left (Ram) 13.Rawtekk Feat Audeka - Extinction (Med School dub) 14.Counterstrike - Shockwave (Algorythm) 15.Crtcl Swtch - Devils Dance (Monstersound) 16.Skynet - Disorder (Neonlight Remix) 17.The Clamps - Aekon (Kosenprod) 18.Telekinesis - Break (Blackout music) 19.Signal Segment and Concept Vision - Medium(Critical) 20.Proxima - Get Ya (Neodigital) 21.Drifta ft Oversight Chaksa Static & Audiosketch - Antimatter (Concor Dawn remix)(Soul Trader) 22.Segment and Concept Vision - Radiant (Eat Brain) 23.Muffler - Universe (Unique) GVOZD VIBES 1.Erconomics Koobra Ronya and Flaxi - Youth (LAOS remix)(Erconomics) 2.Maduk feat Nymfo - Just be Good (Hospital) 3.Syncopix - Fast Life (Syncopix) 4.Katy B Feat. Wilkinson & Stamina MC - So Far Away (Virgin Emi) 5.Modefunktion - All The Way (Soul Deep Digital) 6.Northern Zone - Soul Is Still The Same (Limitless) 7.Upfront and Aesthetics - Touch (Smokin riddims) 8.Damageman - Filthy Animal (Ten Ton Beats) 9.Cidtrix Sphereix - Den Bludclart (Rw digital) 10.Lion Uk - Time Step (Klp) 11.Bayou Future Roots - Dread Drone (Amen vip)(Rhythmic Dysfunctions) 12.Gappa G and Tobias - Rain Terror (Hazardous music) 13.Epicentre - Duppied Inna Dance (Deep In The Jungle) 14.John B - Lava (Metalheadz) 15.Calyx and Teebee Feat. Doctor - Ghetto (Ram) 16.Atiq Tangent - Sonorous (Onsetaudio) 17.Decon - Black Lion (Jazzsticks) 18.Radicall - Chemistry Lesson (Offworld) 19.Redeyes Roygreen and Protone - Abstract Era (Vandal LtD) 20.Villem and Mcleod feat Riya - Get To Know (Spearhead) 21.Rawtekk - Restless (MedSchool dub) 22.Decon - Sugar Drop (Jazzsticks) 23.Drumagick - Win The Game (Blu Mar Ten)

record quiet wilkinson mcleod upfront calyx villem maduk g13 nicky blackmarket drifta pirate station soul trader

GVOZD - PIRATE STATION @ RECORD 26042016

Guitar Lessons by FreeGuitarVideos.com

Play Episode Listen Later Apr 26, 2016 119:50

Это ночное приключение с Пиратской Станцией несло вибрации позитива, любви и конечно свежести звука нашей музыки! Перепрыгивая с гребня на гребень волн разных сабжанров, постарался осветить Сцену и еще больше привлечь вас в ряды dnb людей;) Вместе на этом пути?m/ GVOZD vibes 1.Urbandawn - Messiah Complex (Hospital dub) 2.Signal - No Control (Critical) 3.Proxima - Ruff Scuff (Neodigital) 4.Bad Influence - Spice (Cutting Edge sounds) 5.Nicky Blackmarket ,Voltage - Uss Enterprise (Annix remix)(Dub Damage) 6.Jedi - Come Get Some (Audio Overload) 7.mr Quiet and Sym On - Over The Edge (Dub Voltage) 8.Pacso - The Trick (Turno remix) (G13) 9.Telekinesis - Listen (Blackout Music) 10.Segment and Concept Vision - Mammoth (Eatbrain) 11.Okuli - Shift Grip (Mindtech) 12.Calyx and Teebee - Nothing Left (Ram) 13.Rawtekk Feat Audeka - Extinction (Med School dub) 14.Counterstrike - Shockwave (Algorythm) 15.Crtcl Swtch - Devils Dance (Monstersound) 16.Skynet - Disorder (Neonlight Remix) 17.The Clamps - Aekon (Kosenprod) 18.Telekinesis - Break (Blackout music) 19.Signal Segment and Concept Vision - Medium(Critical) 20.Proxima - Get Ya (Neodigital) 21.Drifta ft Oversight Chaksa Static & Audiosketch - Antimatter (Concor Dawn remix)(Soul Trader) 22.Segment and Concept Vision - Radiant (Eat Brain) 23.Muffler - Universe (Unique) GVOZD VIBES 1.Erconomics Koobra Ronya and Flaxi - Youth (LAOS remix)(Erconomics) 2.Maduk feat Nymfo - Just be Good (Hospital) 3.Syncopix - Fast Life (Syncopix) 4.Katy B Feat. Wilkinson & Stamina MC - So Far Away (Virgin Emi) 5.Modefunktion - All The Way (Soul Deep Digital) 6.Northern Zone - Soul Is Still The Same (Limitless) 7.Upfront and Aesthetics - Touch (Smokin riddims) 8.Damageman - Filthy Animal (Ten Ton Beats) 9.Cidtrix Sphereix - Den Bludclart (Rw digital) 10.Lion Uk - Time Step (Klp) 11.Bayou Future Roots - Dread Drone (Amen vip)(Rhythmic Dysfunctions) 12.Gappa G and Tobias - Rain Terror (Hazardous music) 13.Epicentre - Duppied Inna Dance (Deep In The Jungle) 14.John B - Lava (Metalheadz) 15.Calyx and Teebee Feat. Doctor - Ghetto (Ram) 16.Atiq Tangent - Sonorous (Onsetaudio) 17.Decon - Black Lion (Jazzsticks) 18.Radicall - Chemistry Lesson (Offworld) 19.Redeyes Roygreen and Protone - Abstract Era (Vandal LtD) 20.Villem and Mcleod feat Riya - Get To Know (Spearhead) 21.Rawtekk - Restless (MedSchool dub) 22.Decon - Sugar Drop (Jazzsticks) 23.Drumagick - Win The Game (Blu Mar Ten)

record quiet wilkinson mcleod upfront calyx villem maduk g13 nicky blackmarket drifta pirate station soul trader

Basic Voice Leading

Play Episode Listen Later Apr 24, 2013 5:44

Voice Leading Within the 2-5-1 is a free jazz guitar lesson by Guy Fenocchi. By using specific chords in a progression you can also create a melody through harmonic movement. Guy will teach you how to play the 2-5-1 in both C and F with voice leading chords. In the first example, the highest note of the chord voicing (2nd string) creates the melody. From D-9 to G13 it stays the same, then drops a half step for G+7, and again for C9. In our second progression, the melody will move up. Get the chord charts at http://www.freeguitarvideos.com/LJ3/voice-leading-251.html

voice basic c9 from d g13

GVOZD - PIRATE STATION @ RECORD 30102012

Play Episode Listen Later Nov 1, 2012 119:19

Этот выпуск пронесся ураганом новинок: битов и басов, звуков и грувов, которые мы испытываем на себе в эти дни на многочисленных днб вечеринках!!! В конце эфира устроил небольшой трибьют фестивалю Пиратская Станция и поставил несколько композиций, звучавших в моем сете на последнем (Московском) ивенте!Welcome, friends! fresh floor madness: 1.Calyx and Teebee ft. Kemo - pure gold (Wilkinson remix) (Ram) 2. Neomind - LOIC (Low Orbit Ion Cannon) (Melting Pot) 3.Verb and Devastate - the killzone (DSCI4) 4.Disprove - mini (First Line Squad Remix) (Ammunition) 5. Konichi - sekund fort (G13) 6.Nickbee and Malk - acropolis (2222) 7.Hemoglobin - avoid (2222) 8.Catharsis - pulsar (Lifestyle) 9.Zero T - roxy music (Dispatch) 10.Technicolour - lights (Bass Drive Tunes) 11.Dynamic - momentary switch (Sheer Velocity) 12.Rewind - love yourself (Infrared) 13.Command Strange and Intelligent Manners - all the stars above (Influenza Media) 14.Sunny Crimea - ain't no game (Influenza Media) 15.David Boomah ft Serocee - forward ever (Unreal Rmx) (V dub) 16.Technimatic - Unfinished Business (ShogunLTD) 17. Noel, Kash, Traffic - old times (Hustle Audio) 18.Audio - soulmagnet (Virus) 19.Feed Me & Crystal Fighters - love is all I got (Friction Remix) (Mau5trap) 20.Original Sin - mad world (Playaz) 21.Catharsis - psycho (Lifestyle) 22.Dirtyphonics - dirty (Metrik Remix) (Dim Mak) 23.Cause4Concern - alchemist (C4C) 24.Gridlok - time goes by (feat Optiv) (51 project) 25.Audio - fringe (Virus) 26.Bcee ft Darrison - so right (Mutated_Forms rmx) (Spearhrad) 27.Bcee - help you (Shock One remix) (Spearhead) 28.Xtrah - discordance (Critical) 29.Paradox - marxism (Paradox Music) 30.Stranjah - prominence (DSCI4) 31..SPL- death (Tech Itch) pirate station rave moods nonmixing: 32. Artificial Intelligence + Command Strange ft. Jamakabi - mad one (Metalheadz) 33. Octane and DLR - set up the set (Dispatch) 34. Secret Panda Society - call the cops (Heavy Artillery) 35. Danny Byrd ft. General Levy - blaze the fire (Hospital) 36. Emperor - fire (Neodigital) 37. John B - light of speed (Extended dnb version) (Beta)

lifestyle viruses hospitals record paradoxes traffic beta ram dynamic emperor verb extended wilkinson rewind dispatch original sin infrared catharsis octane john b dlr spearhead spl disprove calyx feed me optiv malk devastate hemoglobin technicolour metalheadz bcee zero t teebee shockone danny byrd kemo general levy crystal fighters dirtyphonics command strange playaz c4c gridlok g13 intelligent manners nickbee david boomah serocee heavy artillery stranjah xtrah darrison mutated forms tech itch sunny crimea jamakabi cause4concern pirate station dsci4 influenza media hustle audio secret panda society

GVOZD - PIRATE STATION @ RECORD 30102012

Play Episode Listen Later Oct 31, 2012 119:19

Этот выпуск пронесся ураганом новинок: битов и басов, звуков и грувов, которые мы испытываем на себе в эти дни на многочисленных днб вечеринках!!! В конце эфира устроил небольшой трибьют фестивалю Пиратская Станция и поставил несколько композиций, звучавших в моем сете на последнем (Московском) ивенте!Welcome, friends! fresh floor madness: 1.Calyx and Teebee ft. Kemo - pure gold (Wilkinson remix) (Ram) 2. Neomind - LOIC (Low Orbit Ion Cannon) (Melting Pot) 3.Verb and Devastate - the killzone (DSCI4) 4.Disprove - mini (First Line Squad Remix) (Ammunition) 5. Konichi - sekund fort (G13) 6.Nickbee and Malk - acropolis (2222) 7.Hemoglobin - avoid (2222) 8.Catharsis - pulsar (Lifestyle) 9.Zero T - roxy music (Dispatch) 10.Technicolour - lights (Bass Drive Tunes) 11.Dynamic - momentary switch (Sheer Velocity) 12.Rewind - love yourself (Infrared) 13.Command Strange and Intelligent Manners - all the stars above (Influenza Media) 14.Sunny Crimea - ain't no game (Influenza Media) 15.David Boomah ft Serocee - forward ever (Unreal Rmx) (V dub) 16.Technimatic - Unfinished Business (ShogunLTD) 17. Noel, Kash, Traffic - old times (Hustle Audio) 18.Audio - soulmagnet (Virus) 19.Feed Me & Crystal Fighters - love is all I got (Friction Remix) (Mau5trap) 20.Original Sin - mad world (Playaz) 21.Catharsis - psycho (Lifestyle) 22.Dirtyphonics - dirty (Metrik Remix) (Dim Mak) 23.Cause4Concern - alchemist (C4C) 24.Gridlok - time goes by (feat Optiv) (51 project) 25.Audio - fringe (Virus) 26.Bcee ft Darrison - so right (Mutated_Forms rmx) (Spearhrad) 27.Bcee - help you (Shock One remix) (Spearhead) 28.Xtrah - discordance (Critical) 29.Paradox - marxism (Paradox Music) 30.Stranjah - prominence (DSCI4) 31..SPL- death (Tech Itch) pirate station rave moods nonmixing: 32. Artificial Intelligence + Command Strange ft. Jamakabi - mad one (Metalheadz) 33. Octane and DLR - set up the set (Dispatch) 34. Secret Panda Society - call the cops (Heavy Artillery) 35. Danny Byrd ft. General Levy - blaze the fire (Hospital) 36. Emperor - fire (Neodigital) 37. John B - light of speed (Extended dnb version) (Beta)

lifestyle viruses hospitals record paradoxes traffic beta ram dynamic emperor verb extended wilkinson rewind dispatch original sin infrared catharsis octane john b dlr spearhead spl disprove calyx feed me optiv malk devastate hemoglobin technicolour metalheadz bcee zero t teebee shockone danny byrd kemo general levy crystal fighters dirtyphonics command strange playaz c4c gridlok g13 intelligent manners nickbee david boomah serocee heavy artillery stranjah xtrah darrison mutated forms tech itch sunny crimea jamakabi cause4concern pirate station dsci4 influenza media hustle audio secret panda society

GVOZD - PIRATE STATION @ RECORD 22052012

Play Episode Listen Later May 22, 2012 117:20

Атмосфера в студии Пиратской Станции в этот раз была подогрета известным в тяжелых днб кругах музыкантом CA2K и его лайв-появлением с мощнейшим гостевым миксом! Я продолжил эфир своим миксом и взглянул на звуки нашей музыки под разными углами! Прогулка по кроссжанрам, новые и хорошо знакомые имена и конечно сумасшедший вайб, в который нельзя не влюбиться ! Let the music play...with you :* CA2K guestmix : 1. C.A.2k - pulsator and prodigy smack my bitch up mashup (Subsistenz) 2. C.A.2K - Matrix (katharsys rmx) (Future sickness) 3. Forbidden Society Facing Descinction Current Value remix (forbidden society__) 4. Cooh and Current Value - Recket (subsistenz_) 5. Konflict - Messiah (C.A.2K and Sinner Fire remix) (bootleg) 6. C.A.2K - Excavator (Future sickness vinyl) 7. C.A.2K -Metal Gear (FutureSickness) 8. Cooh - Moth (Position Chrome) 9. C.A.2K - Dubplate noname 10. Cooh and Ogonek - Iron Curtain (MEtafiziq) 11. C.A.2 and Cooh - Rebirth (Prpspct_) 12. C.A.2K - Excalation (TEch Cycle) GVOZD fresh and clean if you know what i mean mix : 1.Aeph - nightrider (Bad Taste dub) 2.Hadouken - parasite (Break rmx) (Ministry Of Sound) 3. Rico Tubbs - maniac (Hectix rmx) (dub) 4. dj Panik and dj Yox - in the beggining (Drumorange) 5. Nais - stop time (Overtech free) 6. Survival and Ant TC1 ft. C.Nicola - locked (Dispatch) 7. Vacuum and Grinda - solid (Respect dub) 8. Teebee vs NpMolvaer - earthbound (Subtitles) 9. Dub Phizix ft. Mc Fox - never been (Critical) 10. Arclight - kemikal (Architecture) 11. Hi - Quadr - one day in Dubai (Respect dub) 12. Savage Rehab - bloom (V dub) 13. Telekom - secret society (G13) 14. Need For Mirrors - ebonics (Zoltar) 15. Sunchase and Nick Bee - belltine (2222) 16. Krot - get riddim (Respect dub) 17. Blokhe4d and Prolix - switchblade (Bad Taste dub) 18. Jayline and Brockout - cranky boat (Re-wired Beatz) 19. Prince Ital Joe ft Marky Mark(Alexx Rave rmx) - happy people (bootleg) 20. Bungle ft Aya Marar - the siren (Camo and Krooked rmx) (Spearhead) 21. Eveson and Joe S - time flows (V dub) 22. Rowpieces - life can be so beautiful (Celsius) 23. Physical Illusion and Sunny Crimea - remember when (Nexgen) 24. Netsky - come alive (Hospital) 25. Item - shooter (dub) 26. DBR UK& Displaced Paranormals - power roll (Architecture) 27. Bit M Glory - country of fools (dub)

future hospitals record respect survival architecture panik celsius item 2k vacuum dispatch camo telekom subtitles bungle beatz bad taste spearhead ministry of sound arclight hadouken netsky nais zoltar krooked nexgen teebee prolix dub phizix need for mirrors g13 cooh sunchase grinda rico tubbs krot jayline dbr uk rowpieces ant tc1 physical illusion sunny crimea pirate station aeph eveson blokhe4d yox displaced paranormals subsistenz hectix mc fox ca2k

GVOZD - PIRATE STATION @ RECORD 22052012

Medizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 07/19

Play Episode Listen Later May 21, 2012 117:20

Атмосфера в студии Пиратской Станции в этот раз была подогрета известным в тяжелых днб кругах музыкантом CA2K и его лайв-появлением с мощнейшим гостевым миксом! Я продолжил эфир своим миксом и взглянул на звуки нашей музыки под разными углами! Прогулка по кроссжанрам, новые и хорошо знакомые имена и конечно сумасшедший вайб, в который нельзя не влюбиться ! Let the music play...with you :* CA2K guestmix : 1. C.A.2k - pulsator and prodigy smack my bitch up mashup (Subsistenz) 2. C.A.2K - Matrix (katharsys rmx) (Future sickness) 3. Forbidden Society Facing Descinction Current Value remix (forbidden society__) 4. Cooh and Current Value - Recket (subsistenz_) 5. Konflict - Messiah (C.A.2K and Sinner Fire remix) (bootleg) 6. C.A.2K - Excavator (Future sickness vinyl) 7. C.A.2K -Metal Gear (FutureSickness) 8. Cooh - Moth (Position Chrome) 9. C.A.2K - Dubplate noname 10. Cooh and Ogonek - Iron Curtain (MEtafiziq) 11. C.A.2 and Cooh - Rebirth (Prpspct_) 12. C.A.2K - Excalation (TEch Cycle) GVOZD fresh and clean if you know what i mean mix : 1.Aeph - nightrider (Bad Taste dub) 2.Hadouken - parasite (Break rmx) (Ministry Of Sound) 3. Rico Tubbs - maniac (Hectix rmx) (dub) 4. dj Panik and dj Yox - in the beggining (Drumorange) 5. Nais - stop time (Overtech free) 6. Survival and Ant TC1 ft. C.Nicola - locked (Dispatch) 7. Vacuum and Grinda - solid (Respect dub) 8. Teebee vs NpMolvaer - earthbound (Subtitles) 9. Dub Phizix ft. Mc Fox - never been (Critical) 10. Arclight - kemikal (Architecture) 11. Hi - Quadr - one day in Dubai (Respect dub) 12. Savage Rehab - bloom (V dub) 13. Telekom - secret society (G13) 14. Need For Mirrors - ebonics (Zoltar) 15. Sunchase and Nick Bee - belltine (2222) 16. Krot - get riddim (Respect dub) 17. Blokhe4d and Prolix - switchblade (Bad Taste dub) 18. Jayline and Brockout - cranky boat (Re-wired Beatz) 19. Prince Ital Joe ft Marky Mark(Alexx Rave rmx) - happy people (bootleg) 20. Bungle ft Aya Marar - the siren (Camo and Krooked rmx) (Spearhead) 21. Eveson and Joe S - time flows (V dub) 22. Rowpieces - life can be so beautiful (Celsius) 23. Physical Illusion and Sunny Crimea - remember when (Nexgen) 24. Netsky - come alive (Hospital) 25. Item - shooter (dub) 26. DBR UK& Displaced Paranormals - power roll (Architecture) 27. Bit M Glory - country of fools (dub)

future hospitals record respect survival architecture panik celsius item 2k vacuum dispatch camo telekom subtitles bungle beatz bad taste spearhead ministry of sound arclight hadouken netsky nais zoltar krooked nexgen teebee prolix dub phizix need for mirrors g13 cooh sunchase grinda rico tubbs krot jayline dbr uk rowpieces ant tc1 physical illusion sunny crimea pirate station aeph eveson blokhe4d yox displaced paranormals subsistenz hectix mc fox ca2k

Platelet activation and platelet-monocyte aggregate formation by the atherosclerotic plaque lipid lysophosphatidic acid

Play Episode Listen Later Oct 11, 2007

Oxidized LDL and platelets play a central role in the pathogenesis of atherosclerosis and ischemic cardiovascular diseases. Lysophosphatidic acid (LPA) is a thrombogenic substance that accumulates in mildly-oxidized LDL and in human atherosclerotic lesions, and is responsible for the initial platelet activation, shape change, induced by mildly-oxidized LDL and extracts of lipid-rich atherosclerotic plaques (Siess et al., 1999 Proc Natl Acad Sci USA 1999). LPA directly induced platelet shape change in blood and platelet-rich plasma (PRP) obtained from all blood donors. Albumin was one of the main inhibiting factors of platelet shape change in plasma. Interestingly LPA, at concentrations slightly above plasma levels, induced platelet shape change and aggregation in blood. 1-alkyl-LPA (16:0) was almost 20-fold more potent than 1-acyl-LPA (16:0). LPA-stimulated platelet aggregation in blood and PRP was donor-dependent. LPA-induced aggregation in blood could be completely blocked by the ADP- scavenging enzyme, apyrase, and antagonists of the platelet ADP-receptors P2Y1 and P2Y12. These substances also inhibited LPA-induced aggregation of platelet-rich plasma, and aggregation and serotonin secretion of washed platelets. These results indicate a central role for ADP-mediated P2Y1 and P2Y12 receptor activation in supporting LPA-induced platelet aggregation and show that LPA synergistically with ADP induces platelet aggregation in blood. Thus antagonists of platelet P2Y1 and P2Y12 receptors, especially in donors highly sensitive to LPA, might be useful in preventing LPA-elicited thrombus formation in patients with cardiovascular diseases. The mechanism of LPA plus ADP-induced aggregation was independent of the Rho/Rho kinase pathway which mediated LPA-induced platelet shape change in blood. LPA, activating G13, but not Gi or Gq synergized also with epinephrine, activating Gi, and serotonin, activating Gq, in amplifying LPA-induced platelet aggregation in washed platelets. LPA/serotonin-induced aggregation was blocked by either ADP-receptor antagonist whereas synergistic aggregation induced by LPA/epinephrine was independent from ADP-receptor antagonists. The latter results demonstrate an additional mechanism for aggregation independent of P2Y1 and P2Y12. Most surprising, LPA-induced platelet aggregation was insensitive to inhibition by aspirin. LPA at low concentrations, starting slightly above plasma level, was also capable of eliciting platelet-monocyte conjugate formation. LPA-induced platelet-monocyte formation was independent of the blood donor. ADP mediated P2Y1 and P2Y12 receptor activation played only a minor role. Platelet-monocyte aggregate formation stimulated by LPA was P-selectin-mediated and insensitive to inhibition by aspirin. Pathophysiolocical events such as sudden plaque rupture or progressive enrichment of circulating oxidized LDL at critical sites of turbulent flow might lead to higher local blood concentration of LPA. This can induce platelet shape change, platelet aggregation and platelet-monocyte formation at atherosclerotic sites. LPA receptor antagonists could be of possible benefit not only preventing arterial thrombosis, but also retarding vascular inflammation in patients with cardiovascular disease.

formation gi acid gq activation adp ldl prp plaque lipids aggregate platelet lpa albumin p2y12 g13 atherosclerotic monocyte ddc:600 proc natl acad sci usa

The Rikter Game

Play Episode Listen Later May 27, 2006 18:18

"The Rikter Game" ...featuring G13 and MR07 with soundtrack by Matti Paalanen. "The Rikter Game" is a cautionary tale about manipulation of the mass media, propaganda as entertainment and casual attitudes toward racism set in a future climate.For all the info on the author and his book...

game science books fiction sci fi tape thirteen nails inch nin g13 matti paalanen 2mjpeyqxbvi

Lord of the Broken Watchtower Part 2

Play Episode Listen Later Dec 16, 2005 9:12

Part Two of "Lord of the Broken Watchtower" ...featuring The Brothers Blip and soundtrack by Nine Inch Nails; thanks to their support of open source mixing."Lord of the Broken Watchtower" is a futuristic tale of modern urban alienation and the unhealthy desires that are born of our new cyber socialization.For all the info on the author and his book...

lord science books fiction sci fi tape thirteen nails inch nine inch nails nin watchtower g13 2mjpeyqxbvi

Lord of the Broken Watchtower Part 1

Play Episode Listen Later Nov 7, 2005 3:22

Part One of "Lord of the Broken Watchtower" ...featuring The Brothers Blip and soundtrack by Nine Inch Nails; thanks to their support of open source mixing."Lord of the Broken Watchtower" is a futuristic tale of modern urban alienation and the unhealthy desires that are born of our new cyber socialization.For all the info on the author and his book...

lord science books fiction sci fi tape thirteen nails inch nine inch nails nin watchtower g13 2mjpeyqxbvi

Lord of the Broken Watchtower Part 1