Podcasts about Paradigm

Gabriel Pereyra and Winston Weinberg started legal AI company Harvey in 2022 as roommates in a San Francisco apartment. Pereyra had been working on AI research at Meta and Google, while Weinberg was a first-year litigation associate at O'Melveny & Myers. Today, they still share that same apartment, but their company has grown into a global enterprise serving more than 1,000 law firms and corporate legal departments and valued at a whopping $8 billion. In this episode of LawNext, Pereyra and Weinberg take us back to Harvey's earliest days, when they were sending thousands of LinkedIn messages trying to get anyone to look at their product. They share the pivotal moment when early access to GPT-4 transformed what they could build, the breakthrough that came when Allen & Overy became their first major client, and how they have evolved from building an AI assistant for individual lawyers to constructing what they call "essential infrastructure" for legal work. With host Bob Ambrogi, they discuss Harvey's vision for becoming an AI operating system that integrates across the entire legal tech ecosystem, their focus on memory and agentic AI that can handle complex multi-step workflows, and the massive infrastructure challenges of deploying AI at scale across global law firms while maintaining ethical walls and data security.  Pereyra and Weinberg also reflect candidly on how two founders with no management experience have learned to scale a company now employing hundreds of people — more than 20 percent of whom are lawyers — and what it is like to go from struggling startup to being featured in The New York Times as AI billionaires while still sleeping on a mattress on the floor.   Thank You To Our Sponsors This episode of LawNext is generously made possible by our sponsors. We appreciate their support and hope you will check them out.   Paradigm, home to the practice management platforms PracticePanther, Bill4Time, MerusCase and LollyLaw; the e-payments platform Headnote; and the legal accounting software TrustBooks. Briefpoint, eliminating routine discovery response and request drafting tasks so you can focus on drafting what matters (or just make it home for dinner). Eve, taking care of the tasks that slow you down so you can operate at your highest potential   If you enjoy listening to LawNext, please leave us a review wherever you listen to podcasts.  

Hey everybody, welcome to the RV Podcast News Edition for Monday, January 19, 2026. I'm Mike Wendland.This is where we cut through the noise and bring you what's really happening right now in the RV lifestyle and the RV industry. Five stories this week, and taken together they paint a clear picture.The RV world is not just changing. It is restructuring.Let's get started.STORY 1. TAMPA SUPERSHOW AND THE MEGA-DEALERS GET EVEN BIGGERThe Florida RV SuperShow wrapped up this weekend in Tampa, and once again it was the Super Bowl of RVing. Huge crowds, massive inventory, and a lot of signals about where the industry thinks things are headed.One number really stood out.Lazydays RV, now operating as Lazydays RV powered by Campers Inn, announced it brought more than 450 RVs to the show. Four hundred and fifty units on the grounds. There were over 1,300 new models here. That means Lazydays, if it really bought that many uits - I didnt count them - accounted for a third of the total new units on display.That is more than confidence. That is making a statement and claiming market power.It highlights how the biggest RV chains keep getting bigger. Camping World, General RV, Blue Compass, and Campers Inn have all been aggressively buying up smaller dealerships across the country.In many markets, those big names now sit next to each other, or even across the street from one another.That kind of saturation creates brutal competition and raises a serious question. How many stores can a market really support?What we kept hearing in Tampa is that 2026 may be the year underperforming locations start quietly closing.We already saw a preview late in 2025 when Camping World abruptly shut down its store in Escanaba, Michigan.For shoppers, this environment cuts both ways. There is more inventory and more choice, but dealers are under pressure to move aging stock. That pressure can work in your favor, if you negotiate wisely.STORY 2. INFLUENCER FATIGUE. THE MARKETING MODEL IS BREAKING DOWNAnother major theme at the Tampa show had nothing to do with floorplans.Influencer fatigue.By our count, there are now at least 500 so-called RV influencers. Probably more. Anyone with a cellphone camera can claim the title, and many have.For years, manufacturers poured money, free gear, and perks into this system.But saturation has changed everything.Behind the scenes, RV manufacturers and marketing teams are saying the influencer model no longer delivers like it once did. They report being flooded with demands for free RVs, guaranteed commissions, and paid travel just to show up.There are clear signs of a pullback.Winnebago has ended relationships with some influencers. Keystone RV has done the same.The issue is trust. When every product is “the best ever,” audiences stop believing any of it.I overheard it firsthand in Tampa. Outside the influencer building, one man said, “I'd be an influencer too if they gave me free stuff. But since that hasn't happened, I don't trust what any of them say. Free stuff and money can buy anything.”That comment captures the problem perfectly.STORY 3. TARIFFS ARE HAMMERING MANUFACTURERS, AND ROADTREK MAY BE THE HARDEST HITAnother major topic of quiet but intense conversation at the SuperShow was tariffs and the damage they are doing to certain RV manufacturers.Start with Europe.The Italian manufacturer Wingamm has been trying to bring compact Class B style motorhomes into the U.S. market for at least the last four years. At one point, the tariff hit on a Wingamm imported from Italy was estimated at roughly $70,000.That nearly killed the effort.The tariff has since been restructured into a fixed import fee announced in mid-2025, about $9,500 on the Oasi 540.1 and roughly $11,100 on other models. Even so, Wingamm has now turned to crowdfunding to help finance its U.S. market entry.Canada is being hit even harder.Many popular Class B vans sold in the U.S. are built in Canada. Tariffs stack up at every step.A prime example is Leisure Travel Vans.Their Unity models use Mercedes Sprinter chassis and major components built in Germany, shipped to Canada, assembled there, and then exported to the United States. Tariffs apply to the chassis, the imported parts, and the finished vehicle.Industry sources say tariffs alone are adding at least $20,000 to the price of a Leisure Travel Vans motorhome. The new Mercedes Benz model that introduced at the show last week was sticker shock on steroids. It's show price was $272,000. For a B + van. Over a quarter of a million dollars! Yikes. And then there's Class B campervan maker Roadtrek, made in Ontario.Roadtrek's situation may be the most severe.The company has struggled since 2019, following a massive financial scandal involving its previous owners that ended in bankruptcy. Roadtrek is currently owned by a French RV company that took control as part of that restructuring.Since then, Roadtrek has faced repeated Mercedes Sprinter chassis shortages, production disruptions, a weak market, and the loss of key personnel.Most recently, Roadtrek lost its longtime National Sales Manager, Mike Williams, widely known across the industry and to customers as “Canada Mike.” He has now joined Sunshine State RVs in Gainesville, Florida, where some are already calling him “Florida Mike.”That is a significant loss of leadership and visibility for the brand.At Tampa, the buzz was everywhere. Roadtrek is struggling badly, and many insiders believe the company may be for sale again. Nothing official, but the talk was constant and came from dealers, current employees,  and industry veterans.Tariffs are a huge reason for all of this pressure.STORY 4. MORE CONSOLIDATION, MIDWEST AUTOMOTIVE DESIGN LIKELY TO BE SOLDAnd speaking of major brands being in play, we're hearing strong indications of another significant acquisition.Multiple sources tell us that Midwest Automotive Design, a high-end builder of luxury Class B motorhomes on the Mercedes-Benz Sprinter platform, is about to be sold.The buyer, according to what we're hearing, is Alliance RV.Alliance RV was founded in 2019 by industry veterans Ryan and Coley Brady and is best known for its Paradigm line of luxury fifth wheels. The company has built a reputation for high-quality construction and strong customer loyalty.Midwest Automotive Design is a powerhouse in the luxury van segment. It is known for models like the Passage and Luxe Cruiser and has also built private-label vans for Ultimate Toys, Chinook, Holiday Rambler, Fleetwood, and American Coach under the REV Group umbrella.This is not a small boutique operation.If confirmed, this move would signal Alliance's expansion beyond towables into the premium motorized market.It reinforces the larger pattern. The RV industry is entering a major consolidation phase, with strong operators positioning themselves to acquire respected niche brands as costs rise and margins tighten.STORY 5. ZION NATIONAL PARK WILL RESTRICT LARGE RVS ON A KEY ROUTENow an important heads-up for anyone planning a Southwest RV trip.Zion National Park has announced a major change taking effect June 7, 2026.Large vehicles will no longer be allowed to travel through the Zion–Mount Carmel Highway, including the famous tunnel.Vehicles longer than about thirty-five feet, wider than seven feet ten inches, taller than eleven feet four inches, or weighing more than fifty thousand pounds will be prohibited. The long-standing escort system for oversized vehicles is being eliminated.The Park Service says the road was never designed for modern RVs and that safety concerns drove the decision.You can still visit Zion, but many large motorhomes and fifth wheels will need alternate routes or off-site parking.This is a major planning issue for RVers heading west.BONUS STORY. HONDA OFFICIALLY ENTERS THE RV SPACE WITH A LIGHTWEIGHT TRAILERAnd here's one of those moments when we get to say, we told you so. This is a BONUS STORY THIS WEEK.Two episodes ago, we reported that Honda was quietly working on something big in the RV space. Now it's official.Honda has unveiled the Base Station Prototype, an all-new lightweight travel trailer designed by Honda engineers at the company's U.S. research and development centers in Los Angeles and Ohio.This is not a rebadged camper. Honda says the Base Station Prototype brings segment-first innovations that only Honda can deliver.The stated goal is to “democratize outdoor adventures.” In plain English, make RVing accessible to more people.Honda designed the Base Station to be towed by many of the most popular vehicles in America, including crossovers like the Honda CR-V and Toyota RAV4, as well as electric vehicles such as the Honda Prologue and Honda's upcoming 0-Series SUV.That is a major shift.Most lightweight trailers still require full-size trucks or large SUVs. Honda is aiming directly at the millions of households that already own smaller vehicles and have been priced out of RV ownership.Honda also says the Base Station will remain competitively priced in the lightweight travel trailer segment, signaling this is not just a concept vehicle but a serious market entry.If Honda follows through, this could reshape the entry-level RV market in a very big way.And as soon as we can see one in person, you know we'll bring you a full report.CLOSINGAlright. That's this week's RV News Edition of the RV Podcast. For links, documents, and deeper background on every story we covered today, be sure to check the show notes on our website at RVPodcast.com. That's our central hub for everything we do, podcasts, blogs, videos, and our community.You can also leave us a voice message, comment, question, or tip right there on the site. We read them all, and many of them help shape future episodes.And a quick reminder that on February 5, I'll be hosting a live, interactive RV Travel Planning Workshop designed to help you plan smarter trips, avoid costly mistakes, and travel with confidence. You'll find all the details and registration information at RVPodcast.com/workshop.That's your RV Podcast Monday News Edition for Jan. 19, 2026. We'll be back Wednesday with our Stories from the Road RV Podcast. I'm Mike Wendland. Thanks for listening, and until next time, have fun, make friends, and find adventure. Happy Trails.Sources and Further Reading2026 Florida RV SuperShow and Dealer ConsolidationLazydays by Campers Inn Brings Over 450 RVs to Tampa Showhttps://rv-pro.com/news/lazydays-by-campers-inn-brings-over-450-rvs-to-tampa-show/Florida RV Trade Association, Official 2026 Florida RV SuperShow Pagehttps://www.frvta.org/show/florida-rv-supershow/Influencer Fatigue and RV Marketing ShiftWinnebago Industries Corporate News and Investor Updateshttps://investor.winnebagoind.com/Keystone RV Company Official Sitehttps://www.keystonerv.com/Tariffs and Cross-Border RV Industry ImpactRV Dealers Association of Canada Update on Counter Tariffshttps://rvbusiness.com/rvda-canada-gives-update-on-counter-tariffs-on-u-s-rvs/How Tariffs Could Impact the RV Industryhttps://www.rv.com/rv/how-tariffs-could-impact-the-rv-industry/Canadian RV Association Statement on U.S.–Canada Tariff Impacthttps://www.rvnews.com/crva-issues-update-on-u-s-canada-tariff-impact/Class B Forum Discussion on Canadian Tariffshttps://www.classbforum.com/threads/canadian-tariffs.654811/Wingamm European Import TariffsWingamm Official Websitehttps://wingamm.com/Wingamm Oasi 540.1 Model Pagehttps://wingamm.com/en/oasi-540-1/Invest in W Motorhome Sales North America (equity crowdfunding on StartEngine)https://www.startengine.com/offering/wmotorhomeLeisure Travel Vans Tariff ExposureLeisure Travel Vans Official Websitehttps://leisurevans.com/Mercedes-Benz Sprinter Global Production Informationhttps://www.mbvans.com/en/sprinter/Roadtrek Company BackgroundCourt-Ordered Receivership for Erwin Hymer Group North America (which included Roadtrek)https://rvldealernews.com/the-court-appointed-receivership-auction-of-erwin-hymer-group-north-america-will-begin-on-tuesday-july-16-and-continue-until-friday-july-19-2019/How Rapido Group Plotted the Rebirth of Roadtrek https://rv-pro.com/features/how-rapido-plotted-rebirth-roadtrek/ Roadtrek Motorhomes Official Websitehttps://roadtrek.com/Alliance RV and Midwest Automotive Design PurchasAlliance RV Official Websitehttps://www.alliancerv.com/Midwest Automotive Design Official Websitehttps://midwestautomotivedesign.com/Midwest Automotive Design About Us Pagehttps://www.midwestautomotivedesign.com/about-us/Midwest Automotive Design Luxe Cruiser Modelhttps://www.midwestautomotivedesign.com/luxury-vans/luxe-cruiser/REV Group Brand Portfoliohttps://www.revgroup.com/our-brands/Zion National Park Large RV RestrictionsZion National Park to Restrict Large Vehicles on Zion–Mount Carmel Highway Beginning June 7, 2026https://www.nationalparkstraveler.org/2026/01/zion-national-park-restrict-large-vehicles-traveling-zion-mt-carmel-highwayZion to Ban Most Large RVs on Mount Carmel Highwayhttps://www.thetraveler.org/zion-to-ban-most-large-rvs-on-mount-carmel-highway-june-7-2026/Honda Enters the RV Market with the Base Station PrototypeHonda Press Release, Honda Unveils Base Station Prototypehttps://hondanews.com/en-US/honda-automobiles/releases/honda-unveils-base-station-prototype-a-lightweight-towable-travel-trailer-with-modular-design-smart-technology-clever-packaging-to-democratize-campingRV Business, Honda Unveils Prototype Base Station Lightweight Camperhttps://rvbusiness.com/honda-unveils-prototype-base-station-lightweight-camper/The Drive, Honda's Secret Project, A Futuristic Camper Trailer You Can Tow With a CR-Vhttps://www.thedrive.com/news/hondas-secret-project-a-futuristic-camper-trailer-you-can-tow-with-a-cr-v

Outline00:00 - Intro03:18 - Early days: why control, M. Athans, and IDSS12:21 - What is gain scheduling?33:37 - Paradigm shifts & the ‘90s: Minnesota → Texas → LA 42:19 - Robustness & fundamental limitations of nonlinear systems57:35 - Set-valued control & estimation01:04:52 - Game theory & multi-agent control 01:28:18 - Learning & dissipativity in games & multi agent AI01:45:03 - KAUST: building something new01:53:33 - On human-algorithmic interaction01:59:07 - Advice to future students: control, jiu-jitsu, and chatbots in education2:10:02 - OutroLinksJeff's website: https://tinyurl.com/52btmmz7CSM interview: https://tinyurl.com/49wh98x7Domain: feedbackcontrol.comM. Athans: https://tinyurl.com/nhbw66waPhD thesis: https://tinyurl.com/5eyxkfm6IDSS: https://tinyurl.com/bdenwy6dResearch on gain scheduling: https://tinyurl.com/55se8zcr Overview of LPV systems: https://tinyurl.com/3ksff58b Åström's lecture: https://tinyurl.com/33mxkkfe Necessity of the small gain theorem: https://tinyurl.com/mjn9eeb4 Sensitivity reduction for nonlinear plants: https://tinyurl.com/23tej5ypRespect the unstable: https://tinyurl.com/3yww5eds Differential inclusion: https://tinyurl.com/4yvc8vccLectures on game theory: https://tinyurl.com/4z8hh3rnDynamic fictitious play: https://tinyurl.com/yc6wsxjjCooperative control and potential games: https://tinyurl.com/4hbmrt72Dissipativity theory in game theory: https://tinyurl.com/3theyc7xPopulation games, stable games, and passivity: https://tinyurl.com/zxwtzv6wGame theory and control: https://tinyurl.com/yencrwm3Higher-order uncoupled learning: https://tinyurl.com/37Support the showPodcast infoPodcast website: https://www.incontrolpodcast.com/Apple Podcasts: https://tinyurl.com/5n84j85jSpotify: https://tinyurl.com/4rwztj3cRSS: https://tinyurl.com/yc2fcv4yYoutube: https://tinyurl.com/bdbvhsj6Facebook: https://tinyurl.com/3z24yr43Twitter: https://twitter.com/IncontrolPInstagram: https://tinyurl.com/35cu4kr4Acknowledgments and sponsorsThis episode was supported by the National Centre of Competence in Research on «Dependable, ubiquitous automation» and the IFAC Activity fund. The podcast benefits from the help of an incredibly talented and passionate team. Special thanks to L. Seward, E. Cahard, F. Banis, F. Dörfler, J. Lygeros, ETH studio and mirrorlake . Music was composed by A New Element.

In the last in a series of interviews recorded during the ClioCon conference in Boston in October 2025, we bring you a doubleheader – two interviews with two of the legal tech company's key executives.  In the first, LawNext host Bob Ambrogi speaks with Reagan Attle, chief marketing officer at Clio since 2017. In a year in which Clio made the biggest acquisition in legal tech history with its $1 billion purchase of vLex, and in which Clio is aiming to dramatically expand its market and its use of AI, what are the challenges and opportunities for the person tasked with leading the company's global brand and marketing strategy? One thing for sure, Attle says: It makes her job more complex. Listen to the interview to hear Attle's perspective.  In the second interview, Ambrogi sits down with A.J. Axelrod, who joined Clio in November 2024 as vice president of payments and financial services. He fills us in on the two financial products unveiled at ClioCon: Clio Capital, a capital-advance program offering law firms fast access to funds for growth or cash-flow management, and Pay Later, a financing option for law firm clients to pay their legal bills in installments, while the firm gets paid up front. He also talks about what else may be on the horizon for fintech at Clio.   Thank You To Our Sponsors This episode of LawNext is generously made possible by our sponsors. We appreciate their support and hope you will check them out. Paradigm, home to the practice management platforms PracticePanther, Bill4Time, MerusCase and LollyLaw; the e-payments platform Headnote; and the legal accounting software TrustBooks. Briefpoint, eliminating routine discovery response and request drafting tasks so you can focus on drafting what matters (or just make it home for dinner). Eve, taking care of the tasks that slow you down so you can operate at your highest potential   If you enjoy listening to LawNext, please leave us a review wherever you listen to podcasts.  

Mindset Guru and NBA/WNBA Trainer Jordan Delks discusses the power of perspective! He poses three great questions to help you align with God's promises instead of our human limitations. The Perspective Paradigm in today's episode is a cheat code to make a shift this week. Tap in today to level up your mindset!

The ISF Podcast celebrates 10 years this year. Over the decade that we've been in your ears every week, Steve has interviewed a lot of fascinating people: visionary business leaders, neuroscientists and physicists, world leaders, and formerly notorious cyber criminals, just to name a few. We have touched on topics like AI, the human mind, cyber resilience, leadership, and the future of technology and society. So, to kick off 2026, we wanted to give you a look back, highlighting the very best of this first decade of the ISF Podcast. And don't worry – we'll link all the episodes in the show notes. Check out our favorite episodes from the last 10 years: Mo Gawdat - Rethinking the Paradigm of Artificial and Human Intelligence Brian Cox — Intellectual Honesty & Learning to be a Leader Hannah Fry - What Data Can & Can't Tell Us About Ourselves Peter Hinssen - The Never Normal Inside the Mind of Today's Cybercriminals (Brett Johnson, Part 1) Steve Wozniak In Conversation with Steve Durbin Captain Tammie Jo Shults - Habits, Hope and Heroes in a Time of Crisis Sadie Creese — Minimising Your Attack Surface Sir Bob Geldof — Challenging Orthodox Thinking Bonus Episode: Reggie Butler — Bringing Your Home to Work Read the transcript of this episodeSubscribe to the ISF Podcast wherever you listen to podcastsConnect with us on LinkedIn and TwitterFrom the Information Security Forum, the leading authority on cyber, information security, and risk management.

From $61M deals to $0 paydays, NYC real estate is not for the faint of heart. In this episode, James and Keith sit down with Scott Hustis, co-founder of Paradigm Advisory at Compass, to talk about how he built one of New York's top-performing real estate teams; one relationship at a time. Scott shares why he runs his team more like a wealth advisory firm than a brokerage, how he built a repeat-and-referral machine in one of the most cutthroat markets in the world, and why most agents simply aren't consistent enough to succeed. Plus, hear: The 9-year story behind his $61M Central Park sale What the "three-phase" marketing plan really looks like in NYC His thoughts on off-market listings, Zillow, and MLS politics The power of mentors, coaches, and long-term compounding If you're burned out, tempted to shortcut the process, or unsure how to build a sustainable business, this is a masterclass in patience, precision, and real trust-building. Give your clients the competitive edge with Zillow's Showcase. Discover how this exclusive, immersive media experience—featuring stunning photography, video, virtual staging, and SkyTour—helps agents drive more views, saves, and shares. Agents using Showcase on the majority of their listings on Zillow list 30% more homes than similar non-Showcase agents. Learn how to stand out and become the agent sellers choose.   https://www.zillow.com/agents/showcase/   Connect with Scott on LinkedIn.   Learn more about Paradigm on Instagram - LinkedIn and online Paradigm Website, Paradigm Advisory Video. Subscribe to Real Estate Insiders Unfiltered on YouTube! https://www.youtube.com/@RealEstateInsidersUnfiltered?sub_confirmation=1   To learn more about becoming a sponsor of the show, send us an email: jessica@inman.com You asked for it. We delivered. Check out our new merch! https://merch.realestateinsidersunfiltered.com/   Follow Real Estate Insiders Unfiltered Podcast on Instagram - YouTube, Facebook - TikTok. Visit us online at realestateinsidersunfiltered.com.   Link to Facebook Page: https://www.facebook.com/RealEstateInsidersUnfiltered Link to Instagram Page: https://www.instagram.com/realestateinsiderspod/ Link to YouTube Page: https://www.youtube.com/@RealEstateInsidersUnfiltered Link to TikTok Page: https://www.tiktok.com/@realestateinsiderspod Link to website: https://realestateinsidersunfiltered.com This podcast is produced by Two Brothers Creative. https://twobrotherscreative.com/contact/  

The Paradigm may be changing around us but Life's main concern is that the paradigm INSIDE us shifts. Otherwise the world outside will see the change but our experience of it won't be any better. It's our consciousness that we inject into life that will make the next era great- or not. This is a clarion call to be radical and ruthless about shedding all the inner fears and shadows that lead our actions and choices astray. That creates all the behaviours we are sick of and want to leave behind. I really pray for you, me, and us to rise above and out of these thoughts that just aren't real, because we deserve it and our world deserves it. Here's to our Rising.Download the 'Align: The Human Design App' in the App Store and on Google PlayGet your free Human Design Chart on our website www.myhumandesign.comTo follow us on Instagram click HERETo connect with Jenna Zoe click HERE

The biggest deal of 2025 – in fact, the biggest deal ever in legal tech – was legal tech company Clio's acquisition of vLex for $1 billion. A global legal research company founded in Spain, vLex had, just two years earlier, merged with the U.S. legal research company Fastcase, and the union of those two companies – which also included the Docket Alarm trove of court docket data – had further accelerated the development of Vincent, vLex's generative AI technology.  Now, with Clio's acquisition of vLex, comes a combustible combination that has the potential to unify the fuel of all that vLex legal research and docket data with Clio's cloud practice management technology to create an unprecedented, AI-driven platform that unifies both the business and practice of law. Against this backdrop, I sat down with Ed Walters, the founder and CEO of Fastcase, during ClioCon in October, to discuss the acquisition and its implications for the legal industry. Walters cofounded Fastcase in 1999 along with his former Covington & Burling colleague Phil Rosenthal. After Fastcase merged with vLex, he became vLex's chief strategy officer. Since the Clio acquisition, he is now Clio's vice president of legal innovation and strategy.  Note: As of this recording, Clio had not yet closed its acquisition of vLex. The deal did finally close on Nov. 10.    Thank You To Our Sponsors This episode of LawNext is generously made possible by our sponsors. We appreciate their support and hope you will check them out. Paradigm, home to the practice management platforms PracticePanther, Bill4Time, MerusCase and LollyLaw; the e-payments platform Headnote; and the legal accounting software TrustBooks. Briefpoint, eliminating routine discovery response and request drafting tasks so you can focus on drafting what matters (or just make it home for dinner). Eve, taking care of the tasks that slow you down so you can operate at your highest potential   If you enjoy listening to LawNext, please leave us a review wherever you listen to podcasts.  

In this episode of the Oncology Brothers podcast, we dived into the key highlights from ASH 2025, focusing on advancements in acute myeloid leukemia (AML) and chronic myeloid leukemia (CML). We welcomed back Dr. Jorge Cortes from the Georgia Cancer Center to discuss key studies from the leukemia space, including the PARADIGM trial comparing Azacitidine plus Venetoclax to traditional 7 + 3 induction chemotherapy for fit patients with newly diagnosed AML. We explore the implications of these findings, the potential for hypomethylating agents in treatment regimens, and the evolving landscape of CML therapies, including the promising results from the ASK4FIRST/ASK2ESCALATE featuring Asciminib. Key topics covered in this episode: ● The PARADIGM trial and its impact on AML treatment strategies ● Real-world evidence on shortened venetoclax dosing ● The role of menin inhibitors in combination therapies ● Patient-reported outcomes and quality of life with asciminib in CML Tune in for an insightful discussion on the future of leukemia treatment and the importance of patient-centered care.  Follow us on social media: •⁠  ⁠X/Twitter: https://twitter.com/oncbrothers •⁠  ⁠Instagram: https://www.instagram.com/oncbrothers •⁠  Website: https://oncbrothers.com/ Don't forget to subscribe for more updates on treatment algorithms, recent approvals, and conference highlights! #OncologyBrothers #ASH2025 #ASH25 #AML #CML #Leukemia #Hematology

Aji and Joël talk all things hackerthons and why taking the time to have a little having fun with your work every now and then is important for developers. Our hosts reflect on their shared experience at a previous RailsConf where they entered a mini hackerthon, why playing around in a creative sandbox is crucial to honing your skills as a dev, and how programming on the fly can teach you a lot about your own strengths and weaknesses. — Read more about Joël's entry in Rails Rumble (https://thoughtbot.com/blog/rails-rumble-roundup), as well as their participation in the RailsConf 2022 mini Hackerthon (https://thoughtbot.com/blog/thoughtbot-presentations-good-vibes-from-railsconf-2022). Thanks to our sponsors for this episode Judoscale - Autoscale the Right Way (https://judoscale.com/bikeshed) (check the link for your free gift!), and Scout Monitoring (https://www.scoutapm.com/). Your hosts for this episode have been thoughtbot's own Joël Quenneville (https://www.linkedin.com/in/joel-quenneville-96b18b58/) and Aji Slater (https://www.linkedin.com/in/doodlingdev/). If you would like to support the show, head over to our GitHub page (https://github.com/sponsors/thoughtbot), or check out our website (https://bikeshed.thoughtbot.com). Got a question or comment about the show? Why not write to our hosts: hosts@bikeshed.fm This has been a thoughtbot (https://thoughtbot.com/) podcast. Stay up to date by following us on social media - YouTube (https://www.youtube.com/@thoughtbot/streams) - LinkedIn (https://www.linkedin.com/company/150727/) - Mastodon (https://thoughtbot.social/@thoughtbot) - BlueSky (https://bsky.app/profile/thoughtbot.com) © 2025 thoughtbot, inc.

Join for a live in person event in Newark New Jersey on February 27 through March 1st https://www.brianscottlive.com/february-2026 Join The Reality Revolution Tribe

Andrew For America presents the third installment of his new miniseries where he plays clips from prominent people telling you the truth about reality and/or telling you exactly what the "big club's" plan for the world is. In this episode, Andrew talks about Tim Walz's recent withdrawal from the governor race in the state of Minnesota, and plays clips from Jacinda Ardern, Ted Turner, Bill Gates, John Brennen, Kier Starmer, Alexander Soros, and others talking about alleged climate change, the need to reduce carbon, and the need to reduce the population of the world! Andrew also talks about partisan hypocrisy and how the American people act no differently than the citizens of Germany acted under Hitler.The song selections are the songs, "Paradigm" and "No Kings" by the band Templeton Pek.Visit allegedlyrecords.com and check out all of the amazing punk rock artists!Visit soundcloud.com/andrewforamerica1984 to check out Andrew's music!Like and Follow The Politics & Punk Rock Podcast PLAYLIST on Spotify!!!Check it out here: https://open.spotify.com/playlist/1Y4rumioeqvHfaUgRnRxsy...politicsandpunkrockpodcast.comFollow Future Is Now Coalition on Instagram @FutureIsOrgwww.futureis.org

Bitcoin developer Brandon Black (ReardenCode) analyzes the reality of the quantum computing threat to Bitcoin. He explains the timeline for potential encryption breaks and why the sky isn't falling just yet. Brandon explains proposed solutions like BIP 360 and OP_CAT, and we debate whether Satoshi's stash will eventually be stolen or confiscated. Notes: * RSA keys moved from 1024 to 4096 bits * 2-3k logical qubits needed to break ECC * Logical qubits need 99.999% accuracy * Biggest quantum factored number is ~15. * BIP 360 new BC1Z address type. Timestamps: 00:00 Start 00:25 The Quantum discussion 02:43 Initial thoughts on Quantum 06:51 How would a Quantum computer work? 11:10 Quantum vs conventional computing 14:25 Rearden's general take on Quantum 16:29 Why so divided on issue? 20:13 Error correction 22:42 You gave it the answer already 25:36 It's not scaling! 30:06 Easily readable research? 34:24 The "hidden" quantum computer 38:08 Crab market = roll FUD dice 39:59 TradFi is jumpy 41:01 The plan 42:57 What is "bitcoin working"? 46:13 Screeching about Core Devs 48:21 Core team & gatekeeping 53:12 BIP 360 56:19 Are MY keys safe now? 1:01:20 Satoshi's coins 1:05:04 Opinions in the community 1:10:56 Bitcoin upgrades coming? The Gwart Show is sponsored by Ellipsis Labs. Backed by Paradigm, Electric Capital and Haun Ventures. The founders, Eugene and Jerry, have experienced Citadel Jane Street in the Solana Core team since launching their order book DEX, Phoenix. They've done over $80 billion in trading volume by making onchain order books competitive with centralized exchanges.  Ellipsis is hiring for New York-based engineers. Work with a small focus team who are results driven, collaborative, and use a modern stack. If you're an engineer who wants to work on infrastructure that's already proven itself in the market, go to ⁠⁠ellipsislabs.xyz⁠⁠. Learn more about your ad choices. Visit megaphone.fm/adchoices

Vladimir Novakovski, CEO of Lighter, explains their pivot from AI to a high-speed DEX. He addresses the controversy behind their zero-fee model and how ZK circuits ensure verifiability. Vlad says they're surprised at the success of Forex on Lighter, future plans for options and fixed income, and addresses community questions about token value and equity rights. Notes:- Spent 18 months building tech stack- 1,000+ trading shops in contact with Lighter- Polymarket has "pretty efficient" pricing Timestamps:00:00    Start00:35    Surprises of success02:50    Winning Perp DEX Season06:30    Regulations11:49    What parts need to be on-chain?16:57    Sidecar21:35    Forex trading flows24:35    Spot markets28:03    Future of zero fees31:15    Public book & toxic flow36:44    Standardizing Perp DEXs40:16    Paths to revenue45:47    User acquisition & tokens49:28    The Hyperliquid Standard56:24    Dealing with trolls The Gwart Show is sponsored by Ellipsis Labs. Backed by Paradigm, Electric Capital and Haun Ventures. The founders, Eugene and Jerry, have experienced Citadel Jane Street in the Solana Core team since launching their order book DEX, Phoenix. They've done over $80 billion in trading volume by making onchain order books competitive with centralized exchanges.  Ellipsis is hiring for New York-based engineers. Work with a small focus team who are results driven, collaborative, and use a modern stack. If you're an engineer who wants to work on infrastructure that's already proven itself in the market, go to ⁠⁠ellipsislabs.xyz⁠⁠. Learn more about your ad choices. Visit megaphone.fm/adchoices

This Mind-Body Solution episode brings together Jared Morningstar and John Buchanan, part of The Mind-at-Large Project, for a deep, intimate exploration of meaning, spirituality, death, grief, psychedelics, religion, and the nature of mind and reality.

John Delaney is CEO and co-founder of Crown. Crown recently raised a $13.5 million Series A round led by Paradigm and is the issuer of BRLV - Brazil's newest and stablecoin with over 360 million BRL subscribed. He joins host Aaron Stanley to discuss Crown's unique approach to capturing institutional flows in Brazil's high-yield environment - namely by letting BRLV holders earn native yield generated from the underlying reserves.The conversation explores BRLV's groundbreaking bankruptcy-remote reserve structure with perfected legal guarantees, making it the first stablecoin globally to implement such comprehensive security protections. Delaney shares insights on Brazil's position as a prime stablecoin market given its massive M2 money supply, crypto-friendly central bank, and positive real interest rates that outpace inflation. He outlines Crown's ambitious 10-year vision to achieve one trillion BRL in circulation, projecting stablecoins will represent high single-digit percentages of Brazil's money supply as financial infrastructure migrates on-chain.You can connect with John on Linkedin------------------------------------------------------------------Brazil Crypto Report is presented by AveniaIf you're building a wallet, a crypto consumer app, or a global payment platform, Avenia is your bridge to Latin America. Instantly connect to PIX, SPEI, and CBU using stablecoins — with one API. No banks. No FX desks. No SWIFT. Move money globally, with full compliance and real-time settlement. Learn more at ⁠⁠⁠⁠⁠⁠⁠avenia.io⁠⁠⁠⁠⁠⁠⁠.------------------------------------------------------------------Figment is the leading independent provider of staking infrastructure with $18B assets under stake and provides the complete solution for over 1000 institutional clients in Latin America and globally. Through its enterprise-grade infrastructure, Figment enables clients such as banks and exchanges, to earn rewards on Proof-of-Stake assets such as Ethereum and Solana, while maintaining the highest standards of security, compliance, and performance.Learn more at ⁠⁠⁠⁠⁠figment.io⁠⁠⁠⁠⁠-------------------------------------------------------------------

Jim Elvidge is an independent researcher and author whose work challenges conventional cosmology by proposing that the universe itself may be a computational system. In The Universe — Solved, Elvidge presents a bold framework suggesting that reality is not fundamentally physical, but information-based, governed by mathematical rules similar to those underlying digital computation. Drawing on concepts from physics, information theory, and philosophy, he explores how space, time, energy, and consciousness may emerge from a deeper informational substrate. Elvidge's ideas invite a radical rethinking of existence—one that blurs the line between science and metaphysics and raises profound questions about the nature of reality and humanity's place within it.Become a supporter of this podcast: https://www.spreaker.com/podcast/the-x-zone-radio-tv-show--1078348/support.Please note that all XZBN radio and/or television shows are Copyright © REL-MAR McConnell Meda Company, Niagara, Ontario, Canada – www.rel-mar.com. For more Episodes of this show and all shows produced, broadcasted and syndicated from REL-MAR McConell Media Company and The 'X' Zone Broadcast Network and the 'X' Zone TV Channell, visit www.xzbn.net. For programming, distribution, and syndication inquiries, email programming@xzbn.net.We are proud to announce the we have launched TWATNews.com, launched in August 2025.TWATNews.com is an independent online news platform dedicated to uncovering the truth about Donald Trump and his ongoing influence in politics, business, and society. Unlike mainstream outlets that often sanitize, soften, or ignore stories that challenge Trump and his allies, TWATNews digs deeper to deliver hard-hitting articles, investigative features, and sharp commentary that mainstream media won't touch.These are stories and articles that you will not read anywhere else.Our mission is simple: to expose corruption, lies, and authoritarian tendencies while giving voice to the perspectives and evidence that are often marginalized or buried by corporate-controlled media

Welcome to The Chopping Block — where crypto insiders Haseeb Qureshi, Tom Schmidt, Tarun Chitra, and Robert Leshner chop it up about the latest in crypto. This episode features special guest Vladimir Novakovski, Founder of Lighter, joining the crew to unpack the fallout from October 10's historic perpetuals liquidation event and the ADL research that sparked a public clash with Hyperliquid. The panel digs into how auto-deleveraging really works, why these failures were long hidden inside centralized exchanges, and what decentralized perps must fix to truly outperform TradFi. The conversation then turns to the intensifying perp wars. With Lighter's zero-fee trading model, premium tiers for pros, and a looming token launch, the hosts debate whether crypto is headed for a Robinhood-style fee reset, why TVL may matter more than volume, and how RWAs, FX perps, and cross-margining are reshaping market structure. Finally, they tackle the growing divide between tokens and equity as devcos get acquired and tokenholders are left behind. Perps are evolving, incentives are breaking — let's get into it. Show Highlights

In this episode, Anthony and Bernie are joined by special guest, Dr. Justin Kaner from Weill Cornell Medicine, to discuss some of the most interesting ASH abstracts in leukemia in 2025! What abstracts should change practice? Listen to find out. Some of the abstracts discussed:PARADIGM: https://meetings-api.hematology.org/api/abstract/vmpreview/296881KMT2A Outcomes (MARROW Consortium and Othman, et al.): https://meetings-api.hematology.org/api/abstract/vmpreview/302582 and https://meetings-api.hematology.org/api/abstract/vmpreview/297333CLIA +/- Ven: https://meetings-api.hematology.org/api/abstract/vmpreview/302047FLT3i studies (and MRD): https://meetings-api.hematology.org/api/abstract/vmpreview/295719 and https://meetings-api.hematology.org/api/abstract/vmpreview/302699 and https://meetings-api.hematology.org/api/abstract/vmpreview/291322ALL GIMEMA Trial (blin + ponatinib): https://meetings-api.hematology.org/api/abstract/vmpreview/296532Menin inhibitor data

In this podcast episode, Amir T. Fathi, MD, reviews data from select presentations in leukemias at the ASH 2025 Annual Meeting, and provides perspectives on the clinical implications of these data for patients with acute myeloid leukemia (AML) or chronic myeloid leukemia (CML), including:Abstract 6: Phase II PARADIGM trial of azacitidine and venetoclax vs conventional intensive chemotherapy for fit patients with newly diagnosed AMLAbstract 47: Phase I/II SAVE trial of revumenib plus decitabine/cedazuridine and venetoclax in the cohort of patients with newly diagnosed AMLAbstract 766: Phase Ib KOMET-007 trial of ziftomenib in combination with venetoclax and azacitidine in newly diagnosed NPM1-mutant AMLAbstract 654: Phase I/II VICEROY trial of venetoclax and azacitidine + gilteritinib in patients with newly diagnosed FLT3-mutated AML ineligible for intensive induction chemotherapyAbstract 903: 3-Yr Update of the phase II FASCINATION trial of asciminib and conventional BCR::ABL1 inhibitors in newly diagnosed CMLAbstract 906: Phase II ASC2ESCALATE trial of asciminib in patients with chronic-phase CML after 1 prior TKIPresenter:Amir T. Fathi, MDDirector, Leukemia ProgramMassachusetts General HospitalAssociate Professor of MedicineHarvard Medical SchoolBoston, MassachusettsContent based on an online CME program supported by educational grants from AstraZeneca, BeOne Medicines, Genentech, Geron Corporation, Incyte, Johnson & Johnson, Lilly, and Novartis Pharmaceuticals Corporation.Link to full program:https://bit.ly/48Ye45N Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

In this "Best of" episode, Dr. Clark discusses the Noah paradigm All the Episodes of the Heidelcast Subscribe to the Heidelcast! Browse the Heidelshop! On X @Heidelcast On Insta & Facebook @Heidelcast Subscribe in Apple Podcast Subscribe directly via RSS Call The Heidelphone via Voice Memo On Your Phone The Heidelcast is available wherever podcasts are found including Spotify. Call or text the Heidelphone anytime at (760) 618-1563. Leave a message or email us a voice memo from your phone and we may use it in a future podcast. Record it and email it to heidelcast@heidelblog.net. If you benefit from the Heidelcast please leave a five-star review on Apple Podcasts so that others can find it. Please do not forget to make the coffer clink (see the donate button below). SHOW NOTES How To Subscribe To Heidelmedia The Heidelblog Resource Page Heidelmedia Resources The Ecumenical Creeds The Reformed Confessions The Heidelberg Catechism The Heidelberg Catechism: A Historical, Theological, and Pastoral Commentary (Lexham Academic) Recovering the Reformed Confession (P&R Publishing, 2008) Why I Am A Christian What Must A Christian Believe? Heidelblog Contributors Support Heidelmedia: use the donate button or send a check to: Heidelberg Reformation Association 1637 E. Valley Parkway #391 Escondido CA 92027 USA The HRA is a 501(c)(3) non-profit organization

Ruslan Fakhrutdinov from Extended Perp Exchange talks about building a unified margin across perps, vaults & yield, spot, and an integrated lending market. He explains critical components for a trustless perp DEX such as self-custody and on-chain solvency checks. Ruslan shares his experience with user acquisition programs, the total cost of execution vs. zero fees, and Extended's transparent fee model. We also discuss gauging sustainable product market fit in a post-airdrop environment and the roadmap for cross-asset collateral. Subscribe to the newsletter! https://newsletter.blockspacemedia.com Notes:* Perp DEX market share grew 15-20%* Vault earns up to 1% in liquidations* Using 90% of vault shares as collateral Timestamps:00:00 Start00:03 Ruslan's background01:12 What is Extended?03:14 What must be on-chain?05:55 Perp DEX liquidity07:09 Calculating price of execution09:06 Zero fees, good or bad?13:22 Promotions vs regular users18:32 UX design21:35 Mobile trading apps23:43 Perp DEX aggregators?27:51 Vault system29:50 Estimating Vault risk34:28 End stage Vault design?38:10 Spot market plans?42:46 Validators43:34 Next 5 years46:10 RWA on DEXs47:53 Wrapping assets vs native49:06 Wrap up The Gwart Show is sponsored by Ellipsis Labs. Backed by Paradigm, Electric Capital and Haun Ventures. The founders, Eugene and Jerry, have experienced Citadel Jane Street in the Solana Core team since launching their order book DEX, Phoenix. They've done over $80 billion in trading volume by making onchain order books competitive with centralized exchanges.  Ellipsis is hiring for New York-based engineers. Work with a small focus team who are results driven, collaborative, and use a modern stack. If you're an engineer who wants to work on infrastructure that's already proven itself in the market, go to ⁠⁠ellipsislabs.xyz⁠⁠. Learn more about your ad choices. Visit megaphone.fm/adchoices

Discover all of the podcasts in our network, search for specific episodes, get the Optimal Living Daily workbook, and learn more at: OLDPodcast.com. Episode 3840: Allison Carmen invites us to shift from rigid expectations to the liberating mindset of Maybe, where uncertainty becomes a source of hope instead of fear. Through personal struggles and everyday dilemmas, she shows how letting go of the need for immediate answers, whether “yes” or “no,” can create space for creativity, resilience, and unexpected solutions. Embracing Maybe opens the door to a life filled with possibility, even when plans fall apart. Read along with the original article(s) here: http://www.allisoncarmen.com/slipping-out-of-maybe/  &  http://www.allisoncarmen.com/the-yes-and-no-paradigm-2/ Quotes to ponder: "Maybe allows us to contemplate the possibilities of life unfolding in many different ways without feeling the need for action the very minute a problem confronts us." "Let Maybe allow you the room to breathe and stretch and open up to all that is possible." "Sometimes, however, the impulse to immediately decide 'yes' or 'no' to the everyday problems and situations that we face is more about playing it safe and clinging to certainty than it is about living life to the fullest." Learn more about your ad choices. Visit megaphone.fm/adchoices

Discover all of the podcasts in our network, search for specific episodes, get the Optimal Living Daily workbook, and learn more at: OLDPodcast.com. Episode 3840: Allison Carmen invites us to shift from rigid expectations to the liberating mindset of Maybe, where uncertainty becomes a source of hope instead of fear. Through personal struggles and everyday dilemmas, she shows how letting go of the need for immediate answers, whether “yes” or “no,” can create space for creativity, resilience, and unexpected solutions. Embracing Maybe opens the door to a life filled with possibility, even when plans fall apart. Read along with the original article(s) here: http://www.allisoncarmen.com/slipping-out-of-maybe/  &  http://www.allisoncarmen.com/the-yes-and-no-paradigm-2/ Quotes to ponder: "Maybe allows us to contemplate the possibilities of life unfolding in many different ways without feeling the need for action the very minute a problem confronts us." "Let Maybe allow you the room to breathe and stretch and open up to all that is possible." "Sometimes, however, the impulse to immediately decide 'yes' or 'no' to the everyday problems and situations that we face is more about playing it safe and clinging to certainty than it is about living life to the fullest." Learn more about your ad choices. Visit megaphone.fm/adchoices

Discover all of the podcasts in our network, search for specific episodes, get the Optimal Living Daily workbook, and learn more at: OLDPodcast.com. Episode 3840: Allison Carmen invites us to shift from rigid expectations to the liberating mindset of Maybe, where uncertainty becomes a source of hope instead of fear. Through personal struggles and everyday dilemmas, she shows how letting go of the need for immediate answers, whether “yes” or “no,” can create space for creativity, resilience, and unexpected solutions. Embracing Maybe opens the door to a life filled with possibility, even when plans fall apart. Read along with the original article(s) here: http://www.allisoncarmen.com/slipping-out-of-maybe/  &  http://www.allisoncarmen.com/the-yes-and-no-paradigm-2/ Quotes to ponder: "Maybe allows us to contemplate the possibilities of life unfolding in many different ways without feeling the need for action the very minute a problem confronts us." "Let Maybe allow you the room to breathe and stretch and open up to all that is possible." "Sometimes, however, the impulse to immediately decide 'yes' or 'no' to the everyday problems and situations that we face is more about playing it safe and clinging to certainty than it is about living life to the fullest." Learn more about your ad choices. Visit megaphone.fm/adchoices

This week, we discuss Polymarket data accuracy, VC involvement in portfolio companies, Paradigm's Tempo testnet launch, reflections on burnout in crypto, and Farcaster's pivot. Enjoy! – Follow Jason: https://x.com/JasonYanowitz Follow Rob: https://x.com/HadickM Follow Santi: https://x.com/santiagoroel Follow Empire: https://twitter.com/theempirepod —- Zcash is encrypted Bitcoin. Your digital bill of rights securing your freedom for the 21st century. Buy, store and spend ZEC privately using Zashi Wallet download today: https://electriccoin.co/zashi/ -- This Empire episode is brought to you by VanEck. Learn more about the VanEck Onchain Economy ETF (NODE): http://vaneck.com/EmpireNODE An investment in the Fund involves a substantial risk and is not suitable for all investors. It is possible to lose your entire principal investment. The Fund may invest nearly all of its net assets in either Digital Transformation Companies and/or Digital Asset Instruments. The Fund does not invest in digital assets or commodities directly. Digital asset instruments may be subject to risks associated with investing in digital asset exchange-traded products (“ETPs”), which include the historical extreme volatility of the digital asset and cryptocurrency market, as well as less regulation and thus fewer investor protections, as these ETPs are not investment companies registered under the Investment Company Act of 1940 (“1940 Act”) or commodity pools for the purposes of the Commodity Exchange Act (“CEA”). Investing involves substantial risk and high volatility, including possible loss of principal. Visit vaneck.com to read and consider the prospectus, containing the investment objective, risks, and fees of the fund, carefully before investing. © Van Eck Securities Corporation, Distributor, a wholly owned subsidiary of Van Eck Associates Corporation. -- Uniswap's Trading API offers plug-and-play access to deep onchain and off-chain liquidity, delivering enterprise-grade crypto trading without the complexity - from one of the most trusted teams in DeFi. Click to get started with seamless, scalable access to Uniswap's powerful onchain trading infrastructure. https://hub.uniswap.org/?utm_source=blockworks&utm_medium=podcast&utm_campaign=ww_web_bw_awa_trading-api_20251117_podcast_clicks – Timestamps: (00:00) intro (06:00) Polymarket Data (09:12)  How Involved Should VCs Be? (14:48) Ads (Zcash) (15:25)  Tempo Testnet Goes Live (28:48) Ads (Zcash) (29:25)  Burnout Across Crypto (49:05) Ads (VanEck, Uniswap) (50:47)  Farcaster Pivots (01:01:27) Content of the Week — Disclaimer: Nothing said on Empire is a recommendation to buy or sell securities or tokens. This podcast is for informational purposes only, and any views expressed by anyone on the show are solely our opinions, not financial advice. Santiago, Jason, and our guests may hold positions in the companies, funds, or projects discussed.

This conversation explores the transformative potential of Bitcoin in rebuilding trust within financial systems. It discusses the current trust deficit in society, the evolution of credit structures, and how Bitcoin can empower individuals to achieve their dreams without liquidating their assets. The speakers emphasize the need for moral courage to innovate credit products that align with Bitcoin's principles, ultimately envisioning a future where trust is restored through decentralized financial systems.TakeawaysBitcoin is seen as a trust machine that can rebuild trust in financial systems.There is a significant trust deficit in society, particularly regarding institutions and governments.Bitcoin offers a transparent and auditable system that can restore confidence in financial arrangements.The concept of credit is evolving from a credit-based system to a money-based system with Bitcoin.Integrating Bitcoin into credit structures can create better financial products and align interests between borrowers and lenders.Bitcoin's finite nature makes it a better store of value compared to fiat currencies.Using Bitcoin for long-term objectives can empower individuals to achieve their dreams without selling their assets.Moral courage is needed to address the challenges in the current credit space and embrace Bitcoin.Innovative credit products can help individuals leverage their Bitcoin without liquidating it.The future of finance can be built on trust-minimized protocols that align incentives and empower communities.KeywordsBitcoin, trust, finance, credit structures, empowerment, innovation, future, community, economic value, educationChapters00:00 Introduction to the Summit of Summits01:21 Rebuilding Trust in Financial Systems with Bitcoin11:54 Reimagining Credit with Bitcoin20:45 The Future of Bitcoin in Credit Structures29:13 Building Trust in Financial Systems29:58 The Future of Data Centers and Bitcoin Mining

This episode breaks down Indiana's historic Big Ten Championship win over Ohio State, the tactical turning points in the game, and what it means for the College Football Playoff picture. Host Noah Drury and guest Tyler Danberg analyze Ohio State's red zone struggles, Indiana's defensive dominance, and how the Hoosiers became the No. 1 seed. The conversation also dives into major coaching moves across the Big Ten, including Penn State hiring Matt Campbell and the turmoil surrounding Michigan's unexpected head coaching vacancy. The episode closes with a look at playoff matchups, bowl game previews, and why the Miami-Notre Dame-Alabama debate left fans divided heading into postseason play.This episode is sponsored in part by TicketSmarter:Use promo code LWOS10 to receive $10 off purchases of $100 or moreUse promo code LWOS20 to receive $20 off purchases of $300 or moreThink smarter.  TicketSmarter

For legal technology company Clio, this was a particularly significant year, marked by major announcements – including its $1 billion acquisition of vLex – that many saw as transformative for the company. This was on full display at the company's ClioCon conference in October, where CEO Jack Newton gave a keynote laying out the company's vision for a new era of AI-driven legal work in which Clio becomes an "intelligent legal work platform" that serves not as a system of record, but as a system of action, powering lawyers through their workdays by automating much of what they do.  In today's episode, recorded live at ClioCon, host Bob Ambrogi sits down with the two key executives leading Clio's product and technology vision: John Foreman, who joined as chief product officer in May, bringing experience from major SaaS companies including MailChimp and Podium, and Jonathan Watson, the chief technology officer who's been with Clio for eight years. They explore the company's ambitious vision to develop AI and expand into larger law firms, discuss how vertical software creates advantages for AI implementation, and explain why understanding the complete client journey enables more powerful automation. Foreman and Watson share insights on moving beyond simple chatbots to AI that can actually take action, the challenges and opportunities of expanding into the enterprise market, and what's next as they work to "finish drawing the owl." "We've started to draw the owl for folks," Foreman says, "and we're going to finish drawing the owl, and it's going to be a beautiful owl." Note: As of this recording, Clio had not yet closed its acquisition of vLex. The deal did finally close on Nov. 10.    Thank You To Our Sponsors This episode of LawNext is generously made possible by our sponsors. We appreciate their support and hope you will check them out. Paradigm, home to the practice management platforms PracticePanther, Bill4Time, MerusCase and LollyLaw; the e-payments platform Headnote; and the legal accounting software TrustBooks. Briefpoint, eliminating routine discovery response and request drafting tasks so you can focus on drafting what matters (or just make it home for dinner). Eve, taking care of the tasks that slow you down so you can operate at your highest potential   If you enjoy listening to LawNext, please leave us a review wherever you listen to podcasts.  

I received a question from reader Brit who said “I see you and other people talking and writing about the weight-inclusive and weight-centric (and sometimes weight-neutral and weight-loss paradigm). I think I know what they mean but could you give a quick explanation?I'm happy to Brit, sometimes it's good to go back to basics! Get full access to Weight and Healthcare at weightandhealthcare.substack.com/subscribe

Do you ever wonder why it is so hard to change? Have you ever wondered why even after you committed to change, you struggle? Today on Like It Matters Radio Mr. Black is going to cover the structure and power of our Belief Systems. Everything we do, or do not do, is driven by a belief. Your brain is not fixed. Your beliefs are not permanent. Your paradigm should not be a prison! A paradigm is a pattern of thinking, a system of lower-level beliefs that construct a structure that has power to build or destroy, to construct or to destruct! Listeners of today’s hour of power will receive an understanding of some of the WHYs and HOWs of what we do. Mr. Black will go over the logical levels of change- the structure of our experience. Listeners will hear about Viktor Frankl, Alfred Adler, Robert Dilts, and Donald Hebb. Listeners will learn about Neuro Linguistic Programming, Neuroscience, paradigms and the structure of beliefs. Mr. Black will also be joined by a graduate of Leadership Awakening from 3 years ago, who talks about the change that happened in class 3 years ago and that has grown into an incredibly changed life! Mr. Black will share his expertise of working in the human potential field for over 32 years. Mr. Black says, “if you have a WHY, then all you need is an understanding of the HOW. That is what I bring to you, your people and your organization- the power of People knowledge and People skill”. Tune into Like it Matters Radio for an hour of Power where listeners can expect: Inspiration, Education and Application and reminded- When you live life, LIKE IT MATTERS- it does! Be sure to Like and Follow us on our facebook page!www.facebook.com/limradio Instagram @likeitmattersradioTwitter @likeitmatters Get daily inspiration from our blog www.wayofwarrior.blog Learn about our non profit work at www.givelikeitmatters.com Check out our training website www.LikeItMatters.Net Always available online at www.likeitmattersradio.comSee omnystudio.com/listener for privacy information.

Anthony and Bernie discuss the PARADIGM study that was presented at the plenary session of ASH 2025 and whether results should change our practice. https://meetings-api.hematology.org/api/abstract/vmpreview/296881

Please visit answersincme.com/860/99066167-replay3 to participate, download slides and supporting materials, complete the post test, and get a certificate. In this activity, experts in nasal polyps discuss personalizing treatment selection in CRSwNP with emerging biologics. Upon completion of this activity, participants should be better able to: Specify the rationale for targeting epithelial cytokines to address unmet needs in the treatment of CRSwNP; and Design strategies to select the appropriate biologics for patients with CRSwNP, as more become available.

Please visit answersincme.com/860/99066167-replay3 to participate, download slides and supporting materials, complete the post test, and get a certificate. In this activity, experts in nasal polyps discuss personalizing treatment selection in CRSwNP with emerging biologics. Upon completion of this activity, participants should be better able to: Specify the rationale for targeting epithelial cytokines to address unmet needs in the treatment of CRSwNP; and Design strategies to select the appropriate biologics for patients with CRSwNP, as more become available.

In this special double-feature episode of Bits + Bips, Unchained executive editor Steve Ehrlich brings listeners two of the clearest investor perspectives on where the crypto markets may be headed next. First, Owen Lau, Managing Director at Clear Street, breaks down why crypto equities remain so tightly correlated to Bitcoin—and what might finally cause that link to break. He unpacks the growing role of stablecoin revenue, Coinbase and Circle's evolving business models, and why a market structure bill in 2026 could reshape the sector. Then, in the second half, Bob Diamond and David Schamis of Hyperliquid Strategies explain why they believe Hyperliquid and its HYPE token represent one of the most compelling opportunities in digital assets. They walk through the rationale for their DAT, Hyperliquid's performance during extreme market volatility, and the broader ecosystem being built through HIP-3 and beyond. Sponsors: Mantle Host: Steve Ehrlich, Executive Editor at Unchained Guests: Owen Lau, Managing Director at Clear Street Bob Diamond, Founding Partner and CEO of Atlas Merchant Capital David Schamis, Founding Partner and CIO of Atlas Merchant Capital Timestamps: 0:00 Introduction 1:23 Owen's outlook on crypto stocks—and what really drives them today 5:19 Why Coinbase's stock is struggling while revenue goes up 7:47 Why so many crypto companies are spending heavily to expand distribution 10:58 Whether the 10/10 crash changed how analysts evaluate public crypto companies 14:41 Will public crypto companies enter prediction markets next? 17:02 How Coinbase and Circle are positioning themselves in this emerging area 23:00 What Citadel Securities' push for SEC regulation of DeFi means for the industry 24:55 How a market structure bill could reshape the outlook for altcoins 27:03 Would a public crypto company buy a DAT trading below its NAV? 28:59 Has the window for crypto IPOs already closed? Part 2  32:57 How David and Bob first got into crypto  38:57 Why a DAT for Hyperliquid is necessary  42:40 Why they say their stock is a major opportunity right now  45:55 How running an altcoin DAT differs from doing one for ETH or BTC  48:54 How the DAT deal was structured—and Paradigm's role  51:38 How they're avoiding the big sell-offs typical in PIPE deals  53:11 Why there was a gap between announcing the DAT and executing it  55:14 Why Sonnet Therapeutics will remain operational post-transaction  57:51 Why the 10/10 liquidation event made Bob more confident in Hyperliquid  1:04:19 The broader Hyperliquid ecosystem—far beyond the DEX  1:06:42 Why David says perps are far better products than options  1:10:12 Why regulatory clarity is critical for Hyperliquid's long-term success  1:13:37 What HIP-3 unlocks for builders building around perps  1:14:46 How prediction markets could integrate with perpetuals  1:15:49 How Hyperliquid can compete with major exchanges and crypto giants  1:21:18 Why Hyperliquid's feed is so much faster than other chains  1:22:28 The $1 billion shelf offering—and how they plan to accumulate more HYPE Learn more about your ad choices. Visit megaphone.fm/adchoices

The Last Trade: Mark Yusko breaks down why the bitcoin cycle isn't dead, how futures and index flows “tame” BTC, why gold and oil remain the real benchmarks, and what this year's post-peak reset signals about an adversarial, institutional future.---

Supply chains are becoming the new frontlines of geopolitics.

The final Big Ten regular season week delivered chaos, dominance, and championship stakes. Indiana made history with a 56–3 destruction of Purdue to stay undefeated, while Ohio State controlled Michigan to remain the nation's top power-rated team. Oregon battled injuries and still secured a key road win at Washington. Iowa capped another strong season with a commanding victory over Nebraska. Minnesota beat Wisconsin in an ugly rivalry game, and Michigan State ended its losing streak versus Maryland while ushering in a new coaching era under Pat Fitzgerald. USC wrapped up a promising defensive season under Lincoln Riley. The Big Ten Championship now features undefeated Indiana vs. elite Ohio State in a playoff-shaping showdown.This episode is sponsored in part by TicketSmarter:Use promo code LWOS10 to receive $10 off purchases of $100 or moreUse promo code LWOS20 to receive $20 off purchases of $300 or moreThink smarter.  TicketSmarter

Sweating it Out: The Shocking Conditioning Secrets of 1923 FootballWe often think of football conditioning as a precise science of hydration, nutrition, and tailored strength programs. But a century ago, the rules of getting in shape were dramatically different. Darin Hayes of Pigskin Dispatch recently dove into the past with Timothy Brown of Football Archaeology to explore an article from the 1923 season, revealing the bizarre, and sometimes dangerous, training philosophies that shaped early gridiron stars.The episode stems from one of Tim's Tidbits titled: How Conditioning took place in 1923.The primary source for this peek into the past is the Wilson Athletic Library, a series of publications giving professional advice for the era. The specific guidance on "conditioning" came from two knowledgeable figures: Potsy Clark, a coach at Kansas (and a future NFL head coach), and John Griffith, the influential commissioner of the Big Ten. Their shared philosophy was heavily rooted in tradition and what they believed to be common sense, even when it defied basic human physiology.The Dangerous Doctrine of "Water Discipline"The most striking, and arguably most harmful, advice given was the strict adherence to water discipline: explicitly telling athletes not to drink water close to or during practice. This widespread but dangerous belief held that withholding water would make players tougher, similar to the old notion of not swimming after eating.As Timothy Brown points out, this practice put players in significant danger, especially when combined with the gear of the era. Everything worn was cotton, wool, or leather—heavy, non-wicking fabrics that made it impossible for players to perspire properly and cool down. Depriving yourself of water while wearing gear that traps heat only compounded the risk of heat-related illness.The Summer Slump PhilosophyThe coaches of 1923 also held a remarkably casual attitude toward summer training. Conditioning, in their minds, wasn't something players needed a formal program for. Instead, the ideal preparation was for athletes to be "farm boys" or to engage in "good outdoor labor" like construction, dock work, or lifeguarding. Any kind of heavy, physical work outside was deemed superior to formalized pre-season training, because that, as Brown notes, is what "training camp was for."Training camp itself was the six-week period designed to get the players in shape. This philosophy was exemplified by the tales of players like Red Grange, who gained legendary strength hauling massive blocks of ice, earning him the nickname "Wheat and Iceman."The Art of Avoiding "Staleness"Clark and Griffith's advice also focused on the non-physical elements of team administration, especially avoiding the dreaded state of "staleness." They believed a coach must walk a delicate balance: working the athletes hard, but not overworking them. If a player was "stale," it was considered the worst thing that could happen to their performance.The key barometer for a coach to know if they had pushed the team too far? Player complaints. While lazy players would complain regardless, a coach knew they had crossed the line when even the hard-working, dedicated athletes started voicing their displeasure.The contrast between the rudimentary, sometimes dangerous, conditioning of 1923 and the hyper-scientific training of today is a fascinating look at how far the gridiron has evolved. It proves that even a century ago, coaches were desperate to find that competitive edge, even if they were wrong about the most fundamental elements of human survival.Join us at the

As new tools using generative AI promise to change the way we litigate and conduct discovery, what are the implications for day-to-day litigation workflows? On today's episode of LawNext, we feature a conversation with three guests about how law firms are navigating the urgency around gen AI adoption while staying grounded in practical realities. LawNext host Bob Ambrogi recorded this conversation at e-discovery company Everlaw's annual Summit in San Francisco, where gen AI was very much the talk of the  conference — from new product announcements to candid discussions about how law firms are actually putting these tools to work. His guests are:  Adam Borgman, senior associate in the labor and employment group at Vorys, Sater, Seymour and Pease.  Julie Brown, director of practice technology at Vorys.  Joshua Schnoll, Everlaw's chief marketing officer. They talk about how Vorys has taken a disciplined approach to mapping lawyers' workflows before plugging in AI, why understanding how your professionals currently work is the essential first step before adopting new technology, and how tools like Everlaw's newly released Deep Dive are helping attorneys find insights across millions of documents that they might never have discovered on their own – including, as you will hear, a rather unexpected story involving Tums. They also discuss the cost considerations around AI, the trust factor that still gives many lawyers pause, and what advice these experts have for firms that have not yet started experimenting with gen AI.    Thank You To Our Sponsors This episode of LawNext is generously made possible by our sponsors. We appreciate their support and hope you will check them out. Paradigm, home to the practice management platforms PracticePanther, Bill4Time, MerusCase and LollyLaw; the e-payments platform Headnote; and the legal accounting software TrustBooks. Briefpoint, eliminating routine discovery response and request drafting tasks so you can focus on drafting what matters (or just make it home for dinner). Eve, taking care of the tasks that slow you down so you can operate at your highest potential   If you enjoy listening to LawNext, please leave us a review wherever you listen to podcasts.  

In this episode, Jordi Visser joins the show to discuss how exponential technologies, shifting demographics, and rising wealth concentration are quietly reshaping the economic landscape in ways traditional macro models can't capture. He hints at why AI, deflation, and political incentives may matter far more than the usual data releases and how Bitcoin fits into this evolving world. Enjoy! __ Follow Jordi: https://x.com/jvisserlabs Follow Felix: https://x.com/fejau_inc Follow Forward Guidance: https://twitter.com/ForwardGuidance Follow Blockworks: https://twitter.com/Blockworks_ Forward Guidance Telegram: https://t.me/+CAoZQpC-i6BjYTEx Forward Guidance Newsletter: https://blockworks.co/newsletter/forwardguidance __ Grayscale offers more than 30 different crypto investment products. Explore the full suite at grayscale.com. Invest in your share of the future. Investing involves risk and possible loss of principal. https://www.grayscale.com/?utm_source=blockworks&utm_medium=paid-other&utm_campaign=brand&utm_id=&utm_term=&utm_content=audio-forwardguidance — Timestamps: (00:00) Introduction (05:15) Why Tech is Breaking Old Macro (12:04) Grayscale Ad (12:41) How to Think About AI Disruptions (19:14) Transition From FCF to Debt-Funded (25:04) .Com Comparisons & Infinite AI Demand (29:05) The Genesis Mission (31:10) Grayscale Ad (31:58) The New Reality of Today's Markets (36:47) Deflation vs Inflation Risks (39:58) Mike Green's Viral Post (41:52) Debt Doom Loop & Curing All Diseases (45:35) Fed Buying Corporate Bonds (47:25) Bitcoin's Digital Moat (54:25) Final Thoughts __ Disclaimer: Nothing said on Forward Guidance is a recommendation to buy or sell securities or tokens. This podcast is for informational purposes only, and any views expressed by anyone on the show are opinions, not financial advice. Hosts and guests may hold positions in the companies, funds, or projects discussed. #Macro #Investing #Markets #ForwardGuidance

Noah Drury takes a look at the Big Ten as it heads toward Rivalry Week and the College Football Playoff.  Oregon took care of business beating USC, a game the Ducks needed to take care of in order to keep their playoff claims in line.  He gives himself a ribbing for imploring you to take the under in Northwestern-Minnesota, which could have been one of the most exciting games of the weekend.  Meanwhile Illinois' lack of run game, helped Wisconsin earn a win at Camp Randall on senior day, and gave Luke Fickell a much-needed win in a rough campaign, and iowa's game winning field goal as time expired made sure Michigan State winless in the conference.  He then gets into Rivalry Week, headlined by #1 Ohio State taking on Michigan, but also features such games like the battle for the Old Oaken Bucket (Indiana-Purdue) and Paul Bunyan's Axe (Wisoncin-Minnesota).This episode is sponsored in part by TicketSmarter:Use promo code LWOS10 to receive $10 off purchases of $100 or moreUse promo code LWOS20 to receive $20 off purchases of $300 or moreThink smarter.  TicketSmarter

In Episode 450 of Hidden Forces, Demetri Kofinas speaks with Lawrence McDonald, the founder of The Bear Traps Report and the author of a recently published book about the risks and investment opportunities present in today's radically reshaped economy titled "How to Listen When Markets Speak." In today's conversation, Demetri and Lawrence discuss how social media and the gamification of investing have amplified behavioral biases and fueled the AI boom, as well as the growth of crypto and other "tertiary" assets. They then zoom out to examine how the macro environment has changed since the Covid 19 pandemic, and how the government's response to both the GFC and covid crisis have sent investors scrambling for new frameworks to help them understand government's role in the economy and how to position themselves and their client's portfolios for a radically new world—one that you will not learn about in financial text books or most macroeconomics courses. Kofinas and McDonald also explore the "dark side of passive investing," the extreme concentration risk present in a handful of AI-linked mega-caps, the risk to markets of more capricious government trade policies, and why Lawrence McDonald believes that one of the most underappreciated opportunity sets in AI lies not at the intersection of semiconductors and AI companies, but in the physical energy and delivery infrastructure needed to power them. Subscribe to our premium content—including our premium feed, episode transcripts, and Intelligence Reports—by visiting HiddenForces.io/subscribe. If you'd like to join the conversation and become a member of the Hidden Forces Genius community—with benefits like Q&A calls with guests, exclusive research and analysis, in-person events, and dinners—you can also sign up on our subscriber page at HiddenForces.io/subscribe. If you enjoyed today's episode of Hidden Forces, please support the show by: Subscribing on Apple Podcasts, YouTube, Spotify, Stitcher, SoundCloud, CastBox, or via our RSS Feed Writing us a review on Apple Podcasts & Spotify Joining our mailing list at https://hiddenforces.io/newsletter/ Producer & Host: Demetri Kofinas Editor & Engineer: Stylianos Nicolaou Subscribe and support the podcast at https://hiddenforces.io. Join the conversation on Facebook, Instagram, and Twitter at @hiddenforcespod Follow Demetri on Twitter at @Kofinas Episode Recorded on 11/17/2025

Our guest-host today is Jan Spencer, and he'll describe his book disguised as a website - A Primer For Paradigm Shift. The Primer is dense with usable information explaining why, how and what paradigm shift can look like in the real world. Paradigm shift is not a fuzzy future utopia, it's a here-and-now work-in-progress. The more people are engaged, the better, so listen and then check out what you have to add to the book/Primer/website!

Brian and Richard are back for Episode 591 of the Chasing Tone Podcast - Did JHS just break a pedal paradigm and has Brian invented a new type of electric guitar?Blake has traveled back in time to the land of 56kb Internet so Brian and Richard are back in control. Brian has caught the illness that everyone else has and Richard has a remedy. Did you see the new JHS "Troika" delay pedal? The guys are really keen to discuss some of the unusual and interesting features and design choices. Brian drops a hint about something nerdy and circuit related which may or may not be comparable to Netflix. IK Multimedia have released the ToneX in a new format and it inspires the chaps to come up with a whole new product. Richard wishes to bring Brian to Englandshire for Christmas.  Are gear influencer's not as influential as they once were? With the change in Youtube's algorithms and the shape of the gear industry seeming to have shifted the guys discuss this in the context of a recent video from friend of the show, Henning Pauly. Brian makes a shocking and frankly deeply disturbing guitar announcement. Big Beans, Wasp Misidentification, The Team of Jake, Bloody mince pies, Widdle widdle strum strum, a Burdensome burden, it's all in this week's Chasing Tone!We are on Patreon now too!Support the show (https://www.patreon.com/chasingtonepodcast)Awesome Courses and DIY mods:https://www.guitarpedalcourse.com/https://www.wamplerdiy.com/Youtube:https://www.youtube.com/@chasingtonepodcastFind us at:https://www.wamplerpedals.com/https://www.instagram.com/WamplerPedals/https://www.facebook.com/groups/wamplerfanpage/Contact us at: podcast@wamplerpedals.comBetween The StatesBetween the States is a podcast where no topic is off-limits. Hosted by...Listen on: Apple Podcasts SpotifySupport the show

Dave Smith brings you the latest in politics! On this episode of Part Of The Problem, Dave and Robbie "The Fire" Bernstein discuss Nick Fuentes' appearance on Tucker Carlson's show, Dave's experience on Steven Crowder's show, and more.Preorder Lauren Smith's book here: https://a.co/d/67djjBpSupport Our Sponsors:BodyBrain - Go to BodyBrainCoffee.com, use code DAVE20 for 20% off your first orderCrowdHealth - https://www.joincrowdhealth.com/promos/potpMonetary Metals - https://www.monetary-metals.com/potp/YoKratom - https://yokratom.com/Part Of The Problem is available for early pre-release at https://partoftheproblem.com as well as an exclusive episode on Thursday!PORCH TOUR DATES HERE:https://www.eventbrite.com/cc/porch-tour-2025-4222673Find Run Your Mouth here:YouTube - http://youtube.com/@RunYourMouthiTunes - https://podcasts.apple.com/us/podcast/run-your-mouth-podcast/id1211469807Spotify - https://open.spotify.com/show/4ka50RAKTxFTxbtyPP8AHmFollow the show on social media:X:http://x.com/ComicDaveSmithhttp://x.com/RobbieTheFireInstagram:http://instagram.com/theproblemdavesmithhttp://instagram.com/robbiethefire#libertarianSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

With RFK Jr. pledging sweeping reforms to pharmaceutical advertising — and the CDC reaffirming that “informed consent is back” — a new era of medical transparency may be taking shape. Yet some physicians are resisting change. Hear their arguments against a safer, more accountable vaccine paradigm.Become a supporter of this podcast: https://www.spreaker.com/podcast/the-highwire-with-del-bigtree--3620606/support.