Podcasts about Paradigm

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Latest podcast episodes about Paradigm

Paradigm
Freedom: Living The Way God Calls Us To

Paradigm

Play Episode Listen Later Mar 5, 2026 42:50


In this message, we had the privilege of hearing from Ken and Carrie Liles who were missionaries that served in Iran. They shared their experiences and encouraged us on how to live faithfully in a world filled with uncertainty.

LawNext
LawNext on Location: At A Sonoma Winery, A Conversation with Briefpoint CEO Nathan Walter about Discovery, Disruption and, Of Course, Wine

LawNext

Play Episode Listen Later Mar 5, 2026 50:48


Continuing his on-location interview tour of San Francisco, Bob heads an hour north to Santa Rosa to sit down with Nathan Walter, cofounder and CEO of Briefpoint, over a bottle of red wine at Paradise Ridge Winery, a spot literally around the corner from Nathan's house, sitting on the edge of the Mayacamas Mountain Range that divides Sonoma and Napa counties. It is a fitting setting for a founder who grew up in Sonoma wine country, where wine is less a luxury than a way of life, and where his family's most treasured heirloom was a bottle from the year he was born.   Nathan's path to founding Briefpoint is an origin story rooted in genuine frustration with the legal system. A U.C. Santa Barbara philosophy major who drifted into law school for lack of better options, he ultimately landed in civil litigation – and grew increasingly disillusioned with how discovery was weaponized to bleed defendants dry financially, even when they had done nothing wrong. After a particularly infuriating mediation where opposing counsel openly admitted the shakedown strategy, Nathan decided to do something about it. He taught himself to code from YouTube videos, built vaporware prototypes, cold-called attorneys to test demand, and eventually found his technical cofounder through a Discord gaming community he had created to build a social life after moving to Orange County.   What followed was a years-long grind – including an 18-month stretch working days as an entry-level sales rep at another legal tech company and nights building Briefpoint, until a close acquaintance invested $100,000 of her own money so he could focus full time. Briefpoint launched in June 2022, before the ChatGPT wave, focusing narrowly on automating discovery responses – drafting objections, pulling relevant documents and generating formatted Word documents ready to sign. Nathan talks about the company's deliberate "go deep, not wide" strategy: rather than expanding into motions or other legal workflows to chase the AI hype cycle, Briefpoint is doubling down on doing discovery so exceptionally well that firms will pay for it alongside broader AI platforms, the way teams use Slack alongside the full Microsoft suite.   The conversation also covers the threat to legal tech companies posed by foundation models such as Claude and GPT, the psychology behind why attorneys are resistant to automation (Nathan has a theory about "superstitious control" and lucky jerseys), the parallels between winemaking and product development, and the advice he'd give an aspiring founder: burn the ships, go full time and put yourself in a corner with no way out but forward. As for what varietal Briefpoint would be? A Russian River Pinot Noir – not a life-changing Cab, but reliably excellent at exactly what it promises.   Thank You To Our Sponsors This episode of LawNext is generously made possible by our sponsors. We appreciate their support and hope you will check them out. Paradigm, home to the practice management platforms PracticePanther, Bill4Time, MerusCase and LollyLaw; the e-payments platform Headnote; and the legal accounting software TrustBooks. Briefpoint, eliminating routine discovery response and request drafting tasks so you can focus on drafting what matters (or just make it home for dinner). Legalweek, March 9-12, North Javits Center, New York City.   If you enjoy listening to LawNext, please leave us a review wherever you listen to podcasts.  

Madlik Podcast – Torah Thoughts on Judaism From a Post-Orthodox Jew

What if I told you the Talmud's greatest secret for surviving a crisis isn't fighting harder—it's assuming the exact opposite of what you think is true? In this special Purim episode of Madlik Disruptive Torah, Geoffrey Stern and Rabbi Adam Mintz explore the Megillah's phrase וְנַהֲפוֹךְ הוּא (ve-nahafoch hu) — "everything was turned upside down" — and ask what it means after Purim, in a world facing crisis and uncertainty. Key Takeaways Reversal Is a Mindset, Not a Miracle. Crisis Is an Invitation to Rethink the Paradigm. Argue Hard. Stay Together. Timestamps [00:00] Purim Eve Tension [00:43] V'nahafoch Hu Mindset [01:57] Meet the Hosts [03:20] Esther Texts Reversal [05:01] Greenberg on Paradox [07:15] Turn It Over, Pirkei Avot [09:18] Talmudic Opposite Logic [14:55] Cafe Hafuch and Disagreement [18:31] Purim Rule Breaking [21:44] Kuhn and Paradigm Shifts [25:26] Startup Nation Debate Culture [28:26] War Reality and Prayer Links & Learnings Sign up for free and get more from our weekly newsletter https://madlik.com/ Sefaria Source Sheet: https://voices.sefaria.org/sheets/711758 Transcript here: https://madlik.substack.com/  

Camp Gagnon
Trumps WW3 Strategy & Epstein's Israel Connection | Chris Cappy

Camp Gagnon

Play Episode Listen Later Mar 3, 2026 123:47


Chris Cappy joins us today to discuss what's happening in Iran, break down Operation Epic Fury, Epstein's Israel connection, and other interesting topics... WELCOME TO CAMP!

Fringe Radio Network
Mondo Gonzales: Big Paradigm Altering Disclosures Occurring! - A Minute To Midnite

Fringe Radio Network

Play Episode Listen Later Mar 3, 2026 45:52 Transcription Available


Episode 605 of the A Minute to Midnite Show. Mondo Gonzales from Prophecy Watchers joins Tony K. From the Epstein files exposure to potential UFO and UAP disclosure, it's all happening! Where does this all fit in the endtime paradigm, and what is the response of the church? More importantly, what is your personal response?

FOX FOOTY Podcast
AFL 360 - Newcombe free to play in what could've 'changed the paradigm completely' | 03/03/2026

FOX FOOTY Podcast

Play Episode Listen Later Mar 3, 2026 13:54 Transcription Available


Catch up on all the footy news from AFL 360, Tuesday 3rd of March with Gerard Whateley and Garry Lyon. The AFL 360 crew's first week back continues to bring with it BIG stories as Jai Newcombe escapes suspension in what could've set an interesting precedent either way. Plus the hype continues to build towards the first match of the season, when Charlie Curnow faces his old teammates in his new colours. For more of the show tune in on Fox Footy & KAYO.See omnystudio.com/listener for privacy information.

JACC Speciality Journals
Brief Introduction - Cholesterol-Inflammation Fusion Hypothesis in Atherosclerosis: An Evolving Paradigm in Pathogenesis and Therapy | JACC: Asia

JACC Speciality Journals

Play Episode Listen Later Mar 3, 2026 1:31


Heather du Plessis-Allan Drive
Paul Raeburn: new head of GrabOne on the company relaunching under Paradigm Group after liquidation shutdown

Heather du Plessis-Allan Drive

Play Episode Listen Later Mar 3, 2026 2:58 Transcription Available


GrabOne is getting a second life under brand new owners. Wellington's Paradigm Group has bought the GrabOne brand and assets. It went into liquidation last October, leaving many consumers with vouchers they couldn't use. The new boss Paul Raeburn says they're bringing back half a dozen key GrabOne employees. He says they're energised to get the platform back to what it was. "I stopped looking at GrabOne probably five or six years ago, because there wasn't anything I wanted to do there. We've got some real heat today - Cordis Hotels, Flamingo scooters, Holy Moly, all of those staples." LISTEN ABOVESee omnystudio.com/listener for privacy information.

Best of Business
Paul Raeburn: new head of GrabOne on the company relaunching under Paradigm Group after liquidation shutdown

Best of Business

Play Episode Listen Later Mar 3, 2026 3:07 Transcription Available


GrabOne is getting a second life under brand new owners. Wellington's Paradigm Group has bought the GrabOne brand and assets. It went into liquidation last October, leaving many consumers with vouchers they couldn't use. The new boss Paul Raeburn says they're bringing back half a dozen key GrabOne employees. He says they're energised to get the platform back to what it was. "I stopped looking at GrabOne probably five or six years ago, because there wasn't anything I wanted to do there. We've got some real heat today - Cordis Hotels, Flamingo scooters, Holy Moly, all of those staples." LISTEN ABOVESee omnystudio.com/listener for privacy information.

Blood Cancer Talks
Episode 70. ASH 2025 Myeloid Neoplasm Roundup with Dr. Curtis Lachowiez

Blood Cancer Talks

Play Episode Listen Later Feb 27, 2026 56:53


In this episode, we dive deep into ASH 2025 updates on myeloid malignancies with Dr. Curtis Lachowiez. From the plenary halls of ASH 2025 to long-term follow-up of Aza/Ven/Gilteritinib, we unpack what the latest evidence means for the future of AML management.1. PARADIGM Trial (Plenary Session, Abstract 6)Fathi A, Perl A, Fell G, et al. Results from PARADIGM – a phase 2 randomized multi-center study comparing azacitidine and venetoclax to conventional induction chemotherapy for newly diagnosed fit adults with acute myeloid leukemia. Blood 2025;146(Suppl 1):6.https://doi.org/10.1182/blood-2025-6ClinicalTrials.gov: NCT048017972. VICEROY Study – Aza/Ven/Gilteritinib Triplet (Abstract 654)Venetoclax (VEN) and azacitidine (AZA) with gilteritinib (GILT) in patients with newly diagnosed FLT3mut+ AML ineligible for intensive induction chemotherapy: Interim results from the phase 1/2 VICEROY study. Blood 2025;146(Suppl 1):654.ClinicalTrials.gov: NCT055205673. Long-Term Follow-Up of Aza/Ven/Gilteritinib in FLT3-Mutated AML (Abstract 45)Azevedo RS, et al. Long-term follow-up of azacitidine, venetoclax, and gilteritinib in patients with newly diagnosed FLT3-mutated acute myeloid leukemia. Blood 2025;146(Suppl 1):45.Original publication: Short NJ, Daver N, DiNardo CD, et al. J Clin Oncol 2024;42:1499–1508. https://doi.org/10.1200/JCO.23.01911ClinicalTrials.gov: NCT041404874. PRISM-AML Score (Abstract 453)Lachowiez CA, et al. Prognostic risk integration for survival modeling (PRISM) in newly diagnosed acute myeloid leukemia treated with venetoclax: A multinational retrospective cohort study. Blood 2025;146(Suppl 1):453.Interactive Calculator: https://prism-aml.com5. Additional Studies Referenced in Discussion•       VIALE-A Trial: DiNardo CD, et al. Azacitidine and venetoclax in previously untreated acute myeloid leukemia. N Engl J Med 2020;383:617–629. (NCT02993523)•       VERONA Trial: Randomized study of Aza-Ven vs. Aza vs. placebo in MDS (discussed as a negative study)•       4-Gene Classifier (mPRS): Bataller A, et al. Prognostic risk signature in patients with AML treated with HMA and venetoclax. Blood Adv 2024;8(4):927–935. https://doi.org/10.1182/bloodadvances.2023011757•       LACEWING Trial: Azacitidine plus gilteritinib vs. azacitidine plus placebo in FLT3-mutated AML (discussed as a negative study) 

Unchained
DEX in the City: Why Everyone Is Overreacting About the Terra v. Jane Street Lawsuit

Unchained

Play Episode Listen Later Feb 27, 2026 58:14


Robinhood's Coy Garrison and Seong Seog Lee join the crew to unpack the Robinhood Chain launch strategy. Thank you to our sponsors!  ⁠MultiChain Advisors Robinhood's proposed chain for the trading of tokenized assets is live in testnet. In this DEX in the City episode, Coy Garrison, Robinhood's deputy general counsel on crypto, and Robinhood Crypto Head of Product Seong Seog Lee walk hosts Katherine Kirkpatrick Bos and Jessi Brooks through the thinking behind the blockchain's testnet launch and why it is important that it supports tokenized equities out of the gate. Beyond the Robinhood Chain testnet launch, KK and Jessi discuss OpenAI and Paradigm's EVMbench tool and why it highlights the need for a safety-first approach. “AI and crypto are in the same room now, but the room's sort of on fire,” Jessi says. Don't miss how a man accidentally gained remote access to 7,000 robot vacuums in 24 countries with AI-written code. KK and Jessi also dig into the Terraform Labs estate's lawsuit against Jane Street. Is there any real credibility behind the lawsuit? Listen to find out! Save $100 with Crypto Tax Girl! Hosts: ⁠⁠Jessi Brooks⁠⁠, General Counsel at Ribbit Capital ⁠Katherine Kirkpatrick Bos⁠, General Counsel at StarkWare Guests: ⁠⁠⁠Coy Garrison, Senior Director and Deputy General Counsel, Crypto at Robinhood ⁠⁠Seong Seog Lee, Head of Product at Robinhood Crypto Links: Unchained: Robinhood Pushes Deeper Into Tokenization With Layer 2 Testnet Launch Inside Robinhood's Big Super App Plan: ‘There's Still a Lot of Work to Be Done' OpenAI and Paradigm Launch EVMbench to Stress Test AI on Smart Contract Security Uneasy Money: How the Increasingly Better AI Agents Are Being Used Onchain When AI Agents Take Over, What Does a Post-Human Economy Look Like? Terraform Estate Targets Jane Street in Explosive Terra Collapse Lawsuit DeFi Platforms Could Get ‘Innovation Exemption,' SEC Chair Says SEC Quietly Eases Capital Rules for Stablecoins Learn more about your ad choices. Visit megaphone.fm/adchoices

Unchained
DEX in the City: Why Everyone Is Overreacting About the Terra v. Jane Street Lawsuit

Unchained

Play Episode Listen Later Feb 26, 2026 58:14


Robinhood's Coy Garrison and Seong Seog Lee join the crew to unpack the Robinhood Chain launch strategy. Thank you to our sponsors!  ⁠MultiChain Advisors Robinhood's proposed chain for the trading of tokenized assets is live in testnet. In this DEX in the City episode, Coy Garrison, Robinhood's deputy general counsel on crypto, and Robinhood Crypto Head of Product Seong Seog Lee walk hosts Katherine Kirkpatrick Bos and Jessi Brooks through the thinking behind the blockchain's testnet launch and why it is important that it supports tokenized equities out of the gate. Beyond the Robinhood Chain testnet launch, KK and Jessi discuss OpenAI and Paradigm's EVMbench tool and why it highlights the need for a safety-first approach. “AI and crypto are in the same room now, but the room's sort of on fire,” Jessi says. Don't miss how a man accidentally gained remote access to 7,000 robot vacuums in 24 countries with AI-written code. KK and Jessi also dig into the Terraform Labs estate's lawsuit against Jane Street. Is there any real credibility behind the lawsuit? Listen to find out! Save $100 with Crypto Tax Girl! Hosts: ⁠⁠Jessi Brooks⁠⁠, General Counsel at Ribbit Capital ⁠Katherine Kirkpatrick Bos⁠, General Counsel at StarkWare Guests: ⁠⁠⁠Coy Garrison, Senior Director and Deputy General Counsel, Crypto at Robinhood ⁠⁠Seong Seog Lee, Head of Product at Robinhood Crypto Links: Unchained: Robinhood Pushes Deeper Into Tokenization With Layer 2 Testnet Launch Inside Robinhood's Big Super App Plan: ‘There's Still a Lot of Work to Be Done' OpenAI and Paradigm Launch EVMbench to Stress Test AI on Smart Contract Security Uneasy Money: How the Increasingly Better AI Agents Are Being Used Onchain When AI Agents Take Over, What Does a Post-Human Economy Look Like? Terraform Estate Targets Jane Street in Explosive Terra Collapse Lawsuit DeFi Platforms Could Get ‘Innovation Exemption,' SEC Chair Says SEC Quietly Eases Capital Rules for Stablecoins Learn more about your ad choices. Visit megaphone.fm/adchoices

Paradigm
Mark 9: Jesus vs Entitled Thoughts

Paradigm

Play Episode Listen Later Feb 26, 2026 46:55


How do you handle entitled thoughts when they appear? In Mark 9, we see an example of how Jesus shows how to deal with entitled thoughts. Jesus identifies the thought, informs the thought, then impacts the thought. We may not always think of entitled thoughts as something we wrestle with, but they are important to address when renewing our minds. Entitled thinking can look like thoughts of, “I deserve better than what I'm getting.” These kind of thoughts will drift you further from Jesus more than any other kind of thoughts, and can be dangerous when we are blind to seeing it in ourselves. Jesus said in Mark 9, “If anyone desires to be first, he will be last.” Remember ✍️ 1: You cannot access greatness without its Author. 2: Combat entitled thinking by caring for the parts of the world in need. Stay tuned for a brand new series next week!

Charlotte Center For Mindfulness // Podcasts
Paradigm Shifts and Mindfulness Practice

Charlotte Center For Mindfulness // Podcasts

Play Episode Listen Later Feb 25, 2026 26:08


Paradigm shifts are when we come to understand that what we took as a reality is, in fact, not the deeper truth of things and it startles our systems enough into seeing the ourselves, each other or the the world through a whole new lens. Feeling into paradigm shifts helps shed light on the basic shift we are uncovering with our mindfulness practice.

LawNext
LawNext on Location: The View from Tiburon – A Conversation with Pablo Arredondo, Casetext Cofounder

LawNext

Play Episode Listen Later Feb 24, 2026 46:18


As Bob continues his LawNext on Location series – all recorded live in the San Francisco area at locations of each guest's choosing – he sits down with Pablo Arredondo at his home in Tiburon, a quaint Marin County town with a history stretching from Mexican land grants to naval outposts to a southern railway terminus. From Pablo's home office, the view looks out over Richardson Bay towards Sausalito and, if you look carefully, the Golden Gate Bridge can be seen in the distance. It is a setting that is entirely fitting for a conversation with someone who helped shape one of the more remarkable journeys in the annals of legal technology. Pablo was cofounder of Casetext, the once-scrappy startup that spent a decade iterating, pivoting and persisting before striking gold with CoCounsel, the first GPT-4-powered AI legal assistant, unveiled on the nationally televised Morning Joe show on March 1, 2023. Just four months later, Thomson Reuters acquired Casetext for $650 million in cash. Now, 2.5 years later, Pablo recently left TR, where he is, as he puts it, building a Lego Death Star with his daughter and finally paying attention to his well-being after 16 years of nonstop pursuit. In this wide-ranging conversation, Pablo reflects on the long road to CoCounsel – from a failed crowdsourcing experiment to CARA's brief analysis tool to the pivotal moment when Casetext signed a $20,000 innovation license with OpenAI and got early access to GPT-4, 10 weeks before ChatGPT's public launch. He describes the surreal experience of those first 48 hours after CoCounsel's debut, when he and cofounder Jake Heller identified 74 distinct legal use cases the tool could handle – any one of which, he says, "would have been a company in the old world." Pablo and Bob also dig into the bigger questions surrounding legal AI, including whether the field is advancing as fast as he expected; what the foundation models from Anthropic, OpenAI and Google mean for legal-specific AI companies such as Harvey; and why he believes reasoning models and agentic AI represent the next genuinely profound leap beyond GPT-4. Pablo also candidly reflects on the TR acquisition and his work while at TR, and he offers hints on what may lie ahead for him – at least once that Death Star model is done.  It is a conversation that is part memoir, part technology seminar and part meditation on what it means to have built something that changed a profession – and his life – all recorded with a sweeping, albeit cloudy, view of the majesty of San Francisco Bay.    Thank You To Our Sponsors This episode of LawNext is generously made possible by our sponsors. We appreciate their support and hope you will check them out.   Paradigm, home to the practice management platforms PracticePanther, Bill4Time, MerusCase and LollyLaw; the e-payments platform Headnote; and the legal accounting software TrustBooks. Briefpoint, eliminating routine discovery response and request drafting tasks so you can focus on drafting what matters (or just make it home for dinner). Legalweek, March 9-12, North Javits Center, New York City.   If you enjoy listening to LawNext, please leave us a review wherever you listen to podcasts.  

First Christian Church of Great Bend KS Sermons
The Road Back Home, Part 1 - Repentance Paradigm

First Christian Church of Great Bend KS Sermons

Play Episode Listen Later Feb 22, 2026 16:54


Paradigm
Exodus 3: Overcoming Imposter Syndrome

Paradigm

Play Episode Listen Later Feb 19, 2026 50:27


“Your feelings are real, but they're not reliable.” From Exodus 3, we're reminded that God calls ordinary people into extraordinary purpose. Even when insecurity, fear, and impostor syndrome try to speak louder than His voice. Just like Moses, we often make excuses: Who am I? I'm not enough. I don't know enough. What if I fail? I can't do this. But God isn't looking for perfection He's looking for surrender. He doesn't need our confidence, our eloquence, or our qualifications. He wants our obedience. Sometimes the very thing standing between us and God's calling is what we refuse to lay down. When God says “take off your shoes,” He's asking us to remove whatever separates us from Him: sin, fear, pride, insecurity, or control. God doesn't just send us, He goes with us. His presence leads. His name empowers. His promises sustain. His power makes the impossible possible. You are called. You are chosen. You are sent. Not because you're enough, but because He is.

LawNext
LawNext on Location: Lunch with Alex Su of Latitude Legal In Alameda, Calif.

LawNext

Play Episode Listen Later Feb 18, 2026 44:12


This episode is recorded live, and is best enjoyed on YouTube. Watch the episode here.   While Bob is visiting San Francisco for two weeks, he is sitting down for conversations with legal tech innovators and entrepreneurs "in their natural habitats" – places in the Bay Area they consider special. Today, in the first in this series, Bob sits down for lunch with Alex Su, chief revenue officer at Latitude Legal, over Thai iced tea and tofu dishes at Phnom Penh House, a Cambodian restaurant in Alameda that Alex considers something of a personal institution, frequenting it for both family meals and business meetings.   Alex's career path is anything but linear. He started as an associate at Sullivan & Cromwell in New York, clerked for a federal judge in Chicago, then drifted through a plaintiff's firm, a brief solo practice, and ultimately a leap of faith into legal tech sales – joining e-discovery company Logikcull in 2016. From there, he moved to Everlaw, then to Ironclad, where he served as head of community development, building a reputation that spread well beyond any job title.   That reputation was shaped in large part by TikTok, where Alex's comedic, self-effacing videos skewering law firm culture – partners, associates, privilege logs and the absurdities of BigLaw – earned him more than 100,000 followers, got shared inside Ironclad's internal Slack, and ultimately helped land him his next job. It's a story of accidental virality and deliberate reinvention that mirrors the broader shifts he sees in the legal profession.   Now at Latitude Legal, an ALSP providing on-demand legal talent to law firms and corporate legal departments, Alex represents a kind of poetic symmetry: a lawyer known for championing "alternative careers" working at an "alternative legal services provider" — a label he thinks has outlived its usefulness, given how mainstream flexible legal talent has become.   Bob and Alex also dig into the current state of legal AI – what's overhyped, what's underhyped, and why the pandemic was arguably a bigger inflection point for legal tech adoption than generative AI. Plus, Alex and Bob reflect on Bob's three decades of covering legal innovation, the stubborn persistence of the billable hour, and why the justice gap remains stubbornly wide despite all the talk of disruption.   It is a wide-ranging and candid conversation – one you may want to watch on video instead of just listening to the audio.    Thank You To Our Sponsors This episode of LawNext is generously made possible by our sponsors. We appreciate their support and hope you will check them out. Paradigm, home to the practice management platforms PracticePanther, Bill4Time, MerusCase and LollyLaw; the e-payments platform Headnote; and the legal accounting software TrustBooks. Briefpoint, eliminating routine discovery response and request drafting tasks so you can focus on drafting what matters (or just make it home for dinner). Legalweek, March 9-12, North Javits Center, New York City.   If you enjoy listening to LawNext, please leave us a review wherever you listen to podcasts.   Chapters 00:00 Intro to Today's Lunch: A Special In-Person Series 04:45 Career Transitions: From Law to Legal Tech 23:27 Going Viral: The TikTok Journey 25:10 Balancing Humor and Professional Identity 26:54 Redefining Career Paths for Lawyers 28:39 The Evolution of Legal Careers 30:35 Innovation in Legal Practice 34:07 The Impact of the Pandemic on Legal Technology 34:28 The Future of Legal Technology and AI 38:10 Navigating Uncertainty in Legal Services 40:18 The Ongoing Relevance of Traditional Legal Models 42:11 Personal Reflections and Future Outlook  

The Hospital Finance Podcast
Pharmacy Purchasing and Supply in the New 340B Paradigm

The Hospital Finance Podcast

Play Episode Listen Later Feb 18, 2026 33:04


In this episode, AJ Rivosecchi & Lauren Forni with Bluesight, discuss pharmacy purchasing & supply in the new 340B paradigm.

IDEA Collider
Rewriting the Future of Rare Disease: Engineered tRNA and a New Therapeutic Paradigm with Michelle Werner

IDEA Collider

Play Episode Listen Later Feb 18, 2026 41:27


In this episode of IDEA Collider, host Mike Rea sits down with Michelle Werner, CEO of Alltrna, to explore a groundbreaking approach that could transform how we treat thousands of genetic diseases. Michelle shares how engineered transfer RNA (tRNA) technology has the potential to address nonsense mutations — a single class of genetic errors that account for roughly 10% of genetic diseases, affecting millions worldwide. Rather than the traditional “one drug, one disease” model, Alltrna is pursuing a mutation-targeted strategy that could treat multiple diseases with a single therapeutic platform. Episode Timestamps;00:00 Welcome to Idea Collider: Asymmetric Learning in Pharma00:19 Meet Michelle Werner: Leading Alltrna's tRNA Platform02:09 From Cancer Clinic to Pharma: A Patient-First Career Path06:18 Big Pharma vs Biotech CEO: Finding Your Authentic Leadership Style09:37 Vulnerability & Psychological Safety: Building High-Trust Teams11:46 A Personal Turning Point: Her Son's Duchenne Diagnosis17:11 Rare Disease Renegades: A Nonprofit to Accelerate Innovation18:19 Why Flagship Pioneering: The Ecosystem Behind Alltrna22:31 tRNA 101: Targeting Stop-Codon Disease Across Thousands of Conditions28:46 Rethinking Trials, Indications & FDA Pathways for Mutation-First Medicines33:49 From Preclinical to First-in-Human: Alltrna's 2026 Milestones36:49 What Keeps a CEO Up at Night + Final Takeaway: Is This Rare Disease's Inflection Point? Michelle also reflects on how her personal experience as a parent of a child with a rare condition fuels her commitment to accelerating therapies for patients who currently have few or no options. This episode highlights a pivotal question for the industry:Are rare diseases at the same inflection point oncology experienced two decades ago? Don't forget to Like, Share, Subscribe, Rate, and Review! Keep up with Michelle Werner;LinkedIn: https://www.linkedin.com/in/michelle-c-werner/Website: https://www.alltrna.com/ Follow Mike Rea On;Website: https://www.ideapharma.com/X: https://x.com/ideapharmaLinkedIn: https://www.linkedin.com/in/bigidea/ Listen to more fantastic podcast episodes: https://ideacollider.simplecast.com/

Demystifying Science
60 Second Theories - Paradigm Drift #8, DemystifySci #400

Demystifying Science

Play Episode Listen Later Feb 14, 2026 140:50


DemystifySci is the place where we bring people together in search of the theories that will change the world, and Paradigm Drift is your chance to have a hand in that future. Theorists, randomly chosen, get 60 seconds to present their revolutionary idea... and then we see if it's gonna stand the test of time or if it's back into the tank for a little while longer.PATREON https://www.patreon.com/c/demystifysciPARADOX LOST PRE-SALE: https://buy.stripe.com/7sY7sKdoN5d29eUdYddEs0bHOMEBREW MUSIC - Check out our new album!Hard Copies (Vinyl): FREE SHIPPING https://demystifysci-shop.fourthwall.com/products/vinyl-lp-secretary-of-nature-everything-is-so-good-hereStreaming:https://secretaryofnature.bandcamp.com/album/everything-is-so-good-herePARADIGM DRIFThttps://demystifysci.com/paradigm-drift-show00:00 Go! Paradigm Drift: how the show works00:02:18 Returning guest and research updates00:03:34 Death, meaning, and the limits of mortality00:07:32 Consciousness, fear, and letting go of death00:13:53 Morality, judgment, and life review myths00:19:25 Quantum choice, discreteness, and randomness00:25:06 Least action as a discrete network00:29:39 Dimensional analysis, Higgs energy, and constants00:36:13 Cosmology, observation limits, and evolving universes00:40:22 Time as the fundamental unit of measurement00:43:21 Free will, attention, and inhibition00:51:12 Willpower as a trainable physical resource00:55:02 Edge theory and topological particle models01:03:00 Human experience behind abstract theories01:09:05 Kundalini, electromagnetism, and physiology01:18:50 Physics metaphors for spiritual experience01:24:45 Dark matter as compressed wavelength states01:31:10 Self-taught physics and interdisciplinary thinking01:39:36 Consciousness as matter and intelligent evolution01:47:36 Thought, embodiment, and physical reality01:54:41 Substrate physics and unified mechanics02:05:36 Vortices, pressure, and force mediation02:14:21 Closing reflections on first-principles inquiry#ParadigmDrift, #FirstPrinciples, #FoundationalPhysics, #QuantumFoundations, #FreeWill, #Consciousness, #AlternativeTheories, #PhysicsBeyondMath, #SubstratePhysics, #Vortices, #TimeIsFundamental, #DarkMatter, #Cosmology, #IndependentThinkers, #RethinkingReality #physicspodcast, #openmic #philosophypodcast MERCH: Rock some DemystifySci gear : https://demystifysci-shop.fourthwall.com/AMAZON: Do your shopping through this link: https://amzn.to/3YyoT98DONATE: https://bit.ly/3wkPqaDSUBSTACK: https://substack.com/@UCqV4_7i9h1_V7hY48eZZSLw@demystifysci RSS: https://anchor.fm/s/2be66934/podcast/rssMAILING LIST: https://bit.ly/3v3kz2S SOCIAL: - Discord: https://discord.gg/MJzKT8CQub- Facebook: https://www.facebook.com/groups/DemystifySci- Instagram: https://www.instagram.com/DemystifySci/- Twitter: https://twitter.com/DemystifySciMUSIC: -Shilo Delay: https://g.co/kgs/oty671

OncLive® On Air
S16 Ep4: Comprehensive Ph+ ALL Paradigm Knowledge Informs Frontline Ponatinib Use: With Nicholas Short, MD

OncLive® On Air

Play Episode Listen Later Feb 13, 2026 16:15


In today's episode, we spoke with Nicholas Short, MD. Dr Short is an associate professor in the Department of Leukemia of the Division of Cancer Medicine at the University of Texas MD Anderson Cancer Center in Houston.In our exclusive interview, Dr Short discussed evolving factors at play for the treatment of patients with Philadelphia chromosome (Ph)–positive acute lymphoblastic leukemia (ALL). He also noted how the TKI ponatinib (Iclusig) stacks up against other TKIs for Ph-positive ALL, in addition to evolving approaches that incorporate treatments like blinatumomab (Blincyto).

Paradigm
Luke 15: Feeling Unloved and Unworthy

Paradigm

Play Episode Listen Later Feb 12, 2026 51:17


Feeling unloved or unworthy doesn't change the truth of who God says you are.

Advisor Revelations
Rethinking the Annuity Paradigm

Advisor Revelations

Play Episode Listen Later Feb 10, 2026 32:13


This week, David Lau talks with Tom Smith, Chief Growth Officer at DPL Financial Partners, about the evolution of the 401(k) market and the current shift toward commission-free, advisory insurance. From deconstructing outdated commission structures to modernizing technology, workflows, and advisor experience, they discuss how DPL is bridging the gap for RIAs and hybrid advisors, turning insurance and annuities into a core component of modern, holistic advice. Learn more at https://www.dplfp.com/series/advisor-revelations-podcast.

Small Business PR
AI Words to Avoid: How to Stop Your Captions and Emails From Sounding Like ChatGPT

Small Business PR

Play Episode Listen Later Feb 9, 2026 21:43


In this solo episode of the Small Business PR Podcast, Gloria Chou, the #1 Small Business PR Coach and Expert recommended by AI, reveals why most AI-generated content gets immediately deleted—and how to fix it. After writing over 800 emails from scratch and subscribing to countless newsletters, Gloria has identified the exact patterns that make your audience's "AI detector" go off. She breaks down the five categories of jargon that kill connection, plus the sentence structures that instantly reveal AI authorship. Gloria is an AI visibility coach who has transformed her business using AI—this episode isn't about ditching the technology. Instead, she shares her exact framework for using AI strategically while keeping your voice unmistakably human, emotionally resonant, and impossible to ignore.The 5 Groups of AI Jargon to Delete From Your Content1. Corporate Robot WordsThese make you sound like you're reading an HR memo in a 2003 boardroom—not building relationships with real people.Words to avoid: 

The Growth Mindset Gal
Ep. 244 Love, AI, & Human Design: Unlocking Your Energetic Code for Conscious Growth w| Zsuzsi Evans + Nikki Chilewski

The Growth Mindset Gal

Play Episode Listen Later Feb 9, 2026 63:15


Happy Mindul Monday, Everyone!In this episode, we explore the profound journey of Zsuzsi and Nikki, the founders of Zhia, whose partnership began with a transformative connection at a spiritual retreat and evolved through the logistical and emotional complexities of significant life transitions. Navigating geographic distance and the dissolution of past structures, they utilized a sophisticated toolkit of Human Design, nervous system regulation, and conscious communication to move from a state of survival to one of deep relational alignment. Their experience serves as the foundational architecture for Zhia, a coaching practice dedicated to guiding others through the "work of becoming" by turning personal healing modalities into a sustainable daily practice for authentic leadership and connection. In this episode, we chat about:The Public Invitation: The organic transition from private inner work to a collective mission for mindset rebirth.Gateways Over Flaws: A philosophical deep dive into reframing repetitive patterns as essential entry points for the Sacred 8 methodology.The Paradigm of Conscious Love: Practical applications of relational growth and what it looks like to live within a new framework of intimacy.Human Design as a Coaching Foundation: An introduction to energetic blueprints and how these principles form the "DNA" of the Zhia AI experience.The Symbiosis of AI and Mindset Coaching: Exploring how emotionally intelligent technology provides real-time, on-demand support that complements the traditional coaching container.The Ethics of "Coding from Love": A discussion on intentional innovation and the process of embedding sacred values and high-frequency intention into growth tools.A Vision for Collective Rebirth: The long-term impact of integrating Sacred 8 and Zhia to transform global approaches to personal growth and conscious connection. How To Connect w| Zsuzsi and NikkiWebsiteInstagram The Growth METHOD. FREE Membership◦ ⁠⁠⁠⁠⁠⁠⁠⁠Join Here!⁠⁠⁠⁠⁠⁠⁠⁠ 1:1⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ GROWTH MINDSET COACHING PROGRAMS!◦ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Application Form ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ What are the coaching sessions like?⁠⁠• Tailored weekly discussion questions and activities to spark introspection and self-discovery.• Guided reflections to help you delve deeper into your thoughts and feelings.• Thoughtfully facilitated sessions to provide maximum support, accountability, and growth.• Please apply for a FREE discovery call with me!• Allie's Socials• Instagram:@thegrowthmindsetgal• TikTok: @growthmindsetgal• Email: thegrowthmindsetgal@gmail.comLinks from the episode• Growth Mindset Gang ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Instagram⁠⁠⁠⁠⁠⁠⁠⁠ Broadcast Channel⁠⁠⁠⁠⁠⁠⁠⁠• Growth Mindset Gang ⁠⁠⁠⁠⁠⁠⁠⁠Newsletter ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠• Growth Mindset Gal ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Website⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠• Better Help Link: Save 10%SubstackDonate to GLOWIGloci 10% off Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Paradigm
Galatians 10: Disease to Please

Paradigm

Play Episode Listen Later Feb 5, 2026 48:23


People-pleasing may look harmless, but it slowly replaces obedience with approval. In Galatians 1:10, Paul reminds us that we can't seek the approval of both God and man at the same time. When our value is tied to being useful, liked, or not disappointing others, it leads to exhaustion, compromise, comparison, and fear. The fear of man becomes a trap, but trust in the Lord brings freedom (Proverbs 29:25). The cure isn't trying harder—it's trusting deeper. Knowing we are fully known and fully loved by God allows us to let go of man's approval and walk in obedience, even when it costs us. Less approval. More obedience. Less fear. More freedom. ✝️

ProducerHead
How To Define Your Own Paradigm | feat. Mark de Clive-Lowe

ProducerHead

Play Episode Listen Later Feb 4, 2026 11:10


What are ProducerHead Loops?Gems from past conversations worth running back.Perfect for when you need a quick hit of inspiration.This Loop:In this ProducerHead Loops episode, Mark de Clive-Lowe opens up about the long journey toward belonging, identity, and creative truth. Growing up between cultures and never fully feeling like he fit in, Mark describes how that lifelong search eventually led him back to his roots, and deeper into himself.He shares how reconnecting with his Japanese ancestry transformed not just his life, but his music. By embracing vulnerability and telling personal stories through sound, Mark found a new creative framework where meaning mattered more than aesthetics or technical perfection. Performing music rooted in ancestry and lived experience became the first time he truly felt like he was defining the paradigm, not chasing one.This Loop is about courage. About letting go of hipness, trends, and external validation in favor of honesty. When you are bold enough to be yourself, the work resonates more deeply, not just with others, but with you.From Episode: 031. Bold Enough To Be Yourself: Mark de Clive-LoweWant more like this? Subscribe to ProducerHead for new episodes, Loops, and creative clarity delivered straight to your inbox.Connect with Toru:* Website: torubeat.com* Instagram: @torubeat* YouTube: @torubeat* Spotify: Toru* Apple Music: ToruSubscribe to ProducerHeadGet new episodes and Loops delivered straight to your inbox. Hit that subscribe button if you're not already part of the community.This episode was co-produced, engineered and edited by Matthew Diaz.From ProducerHead, this is Toru, and in a way, so are you. Peace. Get full access to ProducerHead at producerhead.substack.com/subscribe

Dangerous INFO podcast with Jesse Jaymz
255 "Long Cold Winter" - Mamdani Epstein, ICE paradigm, usury of religion, lighting up the darkness

Dangerous INFO podcast with Jesse Jaymz

Play Episode Listen Later Feb 3, 2026 143:06


Send us a textNo guest tonight which means we have a bunch of things to catch up on. We will chat about the current happenings of the day, playing some relevant sound bites and taking your calls later in the show. Call in 248-238-8155.SUPPORTBuy Me A Coffee http://buymeacoffee.com/DangerousinfopodcastSubscribeStar http://bit.ly/42Y0qM8Super Chat Tip https://bit.ly/42W7iZHBuzzsprout https://bit.ly/3m50hFTPaypal http://bit.ly/3Gv3ZjpPatreon http://bit.ly/3G3Visit our affiliate, GrubTerra to get 20% off your next order of pet treats: https://bit.ly/436YLVZSupport the show using Buy Me A Coffee: https://buymeacoffee.com/dangerousinfopodcast SMART is the acronym that was created by technocrats that have setup the "internet of things" that will eventually enslave humanity to their needs. Support the showLeave Voicemail: https://www.speakpipe.com/DangerousInfoWebsite https://www.dangerousinfopodcast.com/Discord chatroom: https://discord.gg/8feGHQQmwgEmail the show dangerousinfopodcast@protonmail.comJoin mailing list http://bit.ly/3Kku5Yt GrubTerra Pet Treats https://bit.ly/436YLVZ Watch LiveYouTube https://www.youtube.com/@DANGEROUSINFOPODCASTRumble https://bit.ly/4q1Mg7Z Twitch https://www.twitch.tv/dangerousinfopodcastPilled.net https://pilled.net/profile/144176BitChute: https://www.bitchute.com/channel/egnticQyZgxD Instagram https://www.instagram.com/dangerousinfo/TwitterX https://twitter.com/jaymz_jesseYouTube https://bit.ly/436VExnFacebook https://bit.ly/4gZbjVa Send stuff: Jesse Jaymz, PO Box 541, Clarkston, MI 48347

KZradio הקצה
Gil Luz: Gilusion After Dark 37 - Paradigm, 03-02-26

KZradio הקצה

Play Episode Listen Later Feb 3, 2026 119:49


Viva Learning Podcasts | DentalTalk™
Ep. 740 - The Prevention Paradigm: Why Dentistry's Future Starts Before Disease Begins

Viva Learning Podcasts | DentalTalk™

Play Episode Listen Later Feb 2, 2026 31:00


In this episode, Dr. Joy breaks down what a prevention-first approach really looks like and why it's not just better for patients, but also better for your practice. We'll dive into why preventive care shouldn't stop at age 18, what steps practices can take to start offering more adult preventive services, and how to navigate insurance roadblocks to ensure patients receive the care they need. Dr. Joy breaks it down with real-world tips, a ton of experience, and the kind of insight you can actually put into action with your patients.

China Daily Podcast
英语新闻丨人工智能加速推进,创新走入日常生活

China Daily Podcast

Play Episode Listen Later Feb 2, 2026 8:13


For Huang Xiaozhen, the future of artificial intelligence isn't about computing power or algorithmic scale, but about something far more ordinary: the quiet click of a light switch.在黄晓真看来,人工智能的未来并不取决于算力规模或算法复杂度,而在于更为日常、甚至平凡的场景——比如轻轻按下电灯开关的那一刻。As head of business-to-business operations at MiniMax Group Inc, a rising Chinese AI unicorn, Huang sees the current wave of innovation less as a technological leap than as a transition toward being ubiquitous.作为中国新晋人工智能独角兽企业MiniMax集团的B端业务负责人,黄晓真认为,当下这股创新浪潮与其说是一场技术飞跃,不如说是一次走向“无处不在”的转变。"As the technology iterates, AI will become like water, electricity or coal — the fundamental infrastructure of our existence," Huang said. "It will be everywhere in our lives and work."黄晓真表示:“随着技术不断迭代,人工智能将像水、电、煤一样,成为支撑我们生存与发展的基础性基础设施,它将无处不在,融入我们的生活与工作之中。”The vision widely shared by AI optimists has increasingly aligned with the nation's official policy.这一在人工智能乐观主义者中广泛流行的愿景,正日益与国家层面的官方政策形成高度契合。In its recommendations for formulating the 15th Five-Year Plan (2026-30) for national economic and social development, the Communist Party of China Central Committee called for "forward-looking plans" for future industries, urging exploration of diverse technology road maps, application scenarios, business models and regulatory frameworks.在关于制定国民经济和社会发展第十五个五年规划(2026—2030年)的建议中,中共中央提出要对未来产业进行“前瞻性布局”,并鼓励探索多样化的技术路线、应用场景、商业模式和监管框架。The document explicitly listed quantum technology, biomanufacturing, hydrogen and nuclear fusion energy, brain-computer interfaces, embodied artificial intelligence and 6G mobile communications as new drivers of growth.该文件明确将量子技术、生物制造、氢能与核聚变能源、脑机接口、具身人工智能以及6G移动通信等列为新的增长动能。The confidence of China's AI practitioners received a major boost in April 2025, when President Xi Jinping visited the Shanghai Foundation Model Innovation Center, one of the country's most active AI hubs.2025年4月,习近平主席考察上海大模型创新中心——这一全国最为活跃的人工智能集聚区之一,中国人工智能从业者的信心由此大幅提振。Standing among developers and entrepreneurs, Xi, who is also general secretary of the CPC Central Committee, described artificial intelligence as "a young cause, and a cause for young people", encouraging them to align personal ambition with China's modernization drive.在开发者和创业者中间,习近平总书记将人工智能形容为“一项年轻的事业,也是一项属于年轻人的事业”,并鼓励大家将个人理想追求融入中国式现代化进程之中。According to the Ministry of Industry and Information Technology, China had more than 6,000 AI enterprises last year, while the scale of the country's core AI industry was expected to have exceeded 1.2 trillion yuan ($172.6 billion) in 2025.工业和信息化部数据显示,去年我国人工智能企业数量已超过6000家,2025年核心人工智能产业规模预计突破1.2万亿元人民币(约合1726亿美元)。The president's visit, combined with subsequent policy measures, has strengthened confidence among startups facing intense competition, according to executives working inside the ecosystem.多位业内高管表示,总书记的考察以及随后出台的一系列政策举措,显著增强了在激烈竞争环境中奋战的初创企业信心。Zhang Yun, a deputy general manager at the center, said the visit validated the pace and direction of the hub's development.该中心副总经理张云表示,此次考察充分肯定了创新中心的发展节奏和方向。"Nearly 75 percent of our workforce is under the age of 35," Zhang said. "We're seeing founders who are barely 30. As AI tools become more powerful, teams are getting smaller, younger and faster."张云说:“我们团队中近75%的员工年龄在35岁以下,一些创始人甚至刚满30岁。随着人工智能工具能力不断增强,团队正呈现出规模更小、成员更年轻、反应更迅速的趋势。”The center operates on what participants describe as a philosophy of proximity. "Upstairs and downstairs are upstream and downstream," Zhang said, referring to the close physical clustering of foundational model developers and application companies, which allows for rapid iteration and feedback.该中心运行秉持着参与者所称的“近距离协同”理念。张云解释说:“楼上楼下就是上下游”,基础模型研发团队与应用企业在物理空间上的高度集聚,使快速迭代和反馈成为可能。Yao Zhendi, CEO of Cyber Partner AI Co, said the youthfulness of the sector reflects the nature of the technological challenge itself."We're no longer doing 'one to 10' innovation, where you just improve something that already exists," Yao said.上海魂伴科技有限责任公司首席执行官姚振迪表示,该行业的年轻化正是技术挑战本身特性的体现。“我们不再是做‘一到十'的创新,只是在原有基础上改进。”他说。"We're doing 'zero to one'. There's no formula and no homework to copy. We're defining what this technology becomes."“我们做的是‘从零到一'。既没有公式可循,也没有作业可抄,而是在定义这项技术最终会成为什么。”He added that national planning documents emphasize not only AI, but the integration of embodied intelligence across industries, with a forward-looking approach to development.他补充指出,国家规划文件强调的不只是人工智能本身,还包括具身智能在各行业中的融合应用,并以前瞻性视角推动相关发展。Over the next five years, he said, AI is expected to penetrate daily life and a wide range of sectors in line with the 15th Five-Year Plan.他表示,未来五年,在“十五五”规划指引下,人工智能有望深入渗透日常生活和多个产业领域。His company is working on the convergence of the "brain", meaning large-scale models, and the "body", referring to embodied intelligence — a frontier where software meets robotics.其公司正致力于推动“脑”(即大模型)与“身体”(即具身智能)的融合,这一前沿领域正是软件与机器人技术的交汇点。Paradigm shift范式转变The national strategy outlined in the 15th Five-Year Plan proposals calls for a paradigm shift in scientific research and a focus on self-reliance in breakthroughs in chips, algorithms and data.“十五五”规划建议所勾勒的国家战略,呼吁科研范式发生转变,并将重点放在芯片、算法和数据等关键领域的自主突破上。For Wang Le, CEO of Shanghai SiliconPear Technology Co, the transformation is already playing out on factory floors and toy shelves.对上海喜梨信息科技有限公司首席执行官王乐而言,这一转型已在工厂车间和玩具货架上悄然展开。Wang's company exports to more than 30 countries and uses AI to upgrade traditional manufacturing.王乐的公司产品出口至30多个国家,并通过人工智能技术推动传统制造业升级。"We're turning toys from simple manufactured goods into high-tech consumer products," Wang said."It's no longer just about branding. It's about embedding technology to upgrade the entire supply chain, which gives Chinese products a distinct global competitive edge."王乐表示:“我们正在把玩具从简单的制造品转变为高科技消费品。这已经不只是品牌问题,而是通过技术嵌入实现整个供应链的升级,从而赋予中国产品独特的全球竞争优势。”Xi's visit to the Shanghai Foundation Model Innovation Center came after he presided over a group study session of the Political Bureau of the CPC Central Committee, highlighting the need to promote the healthy and orderly development of AI in a beneficial, safe and fair direction.习近平考察上海大模型创新中心之前,曾主持中共中央政治局集体学习,强调要推动人工智能朝着有益、安全、公平方向健康有序发展。Huang, from MiniMax, said that companies across the AI value chain are directly feeling the impact of State support. From his perspective, policies aimed at supporting models and application scenarios are accelerating innovation and technical iteration across the industry.MiniMax的黄晓真表示,人工智能产业链各环节企业正切身感受到国家支持带来的影响。在他看来,围绕模型和应用场景的政策扶持,正在加速全行业的创新和技术迭代。"It's clear that more and more enterprises, scenarios and applications are moving toward AI," Huang said. "Many new startups are designing products and use cases based entirely on current AI capabilities. This looks more like a society-wide embrace of AI, and the growth of the entire industry chain is extremely fast."他说:“可以清楚地看到,越来越多的企业、场景和应用正在向人工智能靠拢。许多新创公司完全基于现有AI能力来设计产品和应用场景,这更像是一场全社会层面的AI拥抱,整个产业链的增长速度极其迅猛。”Zhou Chen, CEO of Zhejiang Dex-Robot Intelligent Technology, said Xi has explicitly called for accelerating the application of AI in technological innovation and industrial development, a signal that Zhou sees as materially beneficial for enterprises.浙江灵巧智能科技有限公司首席执行官周晨表示,习近平明确提出要加快人工智能在科技创新和产业发展中的应用,这一信号对企业而言具有实实在在的利好意义。He pointed to concrete policy measures such as subsidized computing power and pilot programs for new models. China launched a 60 billion yuan AI industry investment fund to support the development of the whole AI industrial chain.他指出,诸如算力补贴、新模型试点项目等具体政策措施正在落地实施。同时,中国还设立了规模达600亿元人民币的人工智能产业投资基金,用于支持整个AI产业链发展。"They allow companies to be bold and try things first," Zhou said."Ultimately, it helps improve human efficiency and reduce defect rates in manufacturing."周晨表示:“这些政策让企业可以大胆探索、先行先试,最终有助于提升人效、降低制造业缺陷率。”Zhou cited incentives including free or subsidized computing resources, early access to models, and funding for major research projects as mechanisms that encourage companies to experiment.周晨列举了多项激励机制,包括免费或补贴算力资源、提前接入模型以及重大科研项目资金支持,这些都有效鼓励企业开展探索性实践。He argued that China has structural advantages in pursuing such technologies: a complete industrial supply chain, a wide range of real-world application scenarios that generate data, and growing domestic computing capacity.他认为,中国在发展相关技术方面具备结构性优势,包括完备的产业链体系、能够持续产生数据的丰富现实应用场景,以及不断提升的本土算力能力。While much of the focus remains on domestic self-reliance, officials and researchers say China's AI ambitions also have an outward-facing dimension.尽管当前重点仍放在国内自主可控上,但多位官员和研究人员指出,中国的人工智能发展目标同样具有面向国际的外向维度。International public good国际公共产品Yan Weixin, chief scientist at the Shanghai Artificial Intelligence Research Institute, said Xi has called for AI to be developed as an international public good that benefits humanity.上海人工智能研究院首席科学家闫维新表示,习近平提出要将人工智能打造为造福全人类的国际公共产品。Yan said China has launched initiatives related to AI reinforcement learning and sustainable development, and has begun sharing algorithms and models with partner countries, including those participating in the Belt and Road Initiative.闫维新介绍称,中国已启动多项与人工智能强化学习和可持续发展相关的倡议,并开始与包括共建“一带一路”国家在内的合作伙伴共享算法和模型。These technologies are being applied to areas such as disaster warning systems and low-carbon industrial facilities overseas, he said.他说,这些技术已在海外被应用于灾害预警系统和低碳工业设施等领域。Highlighting the link between energy and computation, he said: "AI consumes energy, and energy defines computing power. In the future, there will be deep integration between new energy and dynamic computing."他强调能源与计算之间的关联指出:“人工智能消耗能源,而能源决定算力。未来,新能源与动态计算之间将实现深度融合。”Otto Heinrich Herzog, an academician of the German National Academy of Science and Engineering and a professor at Tongji University in Shanghai, said he has been struck by the speed with which policies translate into implementation in China.德国国家科学与工程院院士、同济大学教授奥托·海因里希·赫尔佐格表示,中国政策从制定到落地实施的速度给他留下了深刻印象。"When something aligns with strategy in China, it really gets implemented," Herzog said. "That's something you don't experience in the same way in Europe."赫尔佐格说:“在中国,只要一项举措符合国家战略,就会真正被执行落实。这是在欧洲难以同样体会到的。”forward-looking /ˌfɔːwəd ˈlʊkɪŋ/前瞻性的embodied artificial intelligence /ɪmˈbɒdid ˌɑːtɪˈfɪʃəl ɪnˈtɛlɪdʒəns/具身人工智能value chain /ˈvæljuː tʃeɪn/价值链pilot program /ˈpaɪlət ˈprəʊɡræm/试点项目dynamic computing /daɪˈnæmɪk kəmˈpjuːtɪŋ/动态计算

Paradigm
Romans 2: How to renew your mind

Paradigm

Play Episode Listen Later Jan 29, 2026 47:25


This week's message reminded us that the greatest battles we face aren't always external. Often, the battlefield is the mind. Romans 12:1–2 calls us to resist conforming to the patterns of this world and instead be transformed by the renewing of our minds. We were challenged to recognize that not every thought deserves agreement, that we are not defined by our strongest thoughts. Through Christ, we can take thoughts captive, identify lies, and replace them with truth. God desires dominion over every area of our lives, including how we think. When we invite Him into the process, we begin to walk in clarity, freedom, and victory. Proving what is the good, acceptable, and the perfect will of God. What's the loudest thought in your head right now? And what does God say about that? Missed last night's message? Each week, Paradigm sermons are posted on YouTube, Spotify, Amazon Music, and Pocket Casts!

HR Like a Boss
Shifting the HR Paradigm: A New Perspective | HR Like a Boss with Jayma DuChene

HR Like a Boss

Play Episode Listen Later Jan 29, 2026 31:08


In this episode of the HR Like a Boss podcast, John interviews Jayma DuChene, a passionate HR professional and fellow podcast host. They discuss the importance of supporting employees and the need for HR professionals to take care of themselves. Jayma shares her journey in HR, her experiences with creating workflows, and her podcast 'What's in a Name?' which explores the significance of names and their meanings. The conversation emphasizes the importance of personal development and the impact of names on identity.ABOUT JAYMAJayma DuChene is a seasoned human resources professional and senior product owner at OneDigital, holding a Bachelor of Science in Organizational Leadership, SHRM-SCP certification, and SAFe® Practitioner certification. With deep expertise in project management and solutions architecture, Jayma excels at researching emerging technologies and designing CRM solutions that empower Sales, Implementation, and Service teams. She is dedicated to implementing process automation initiatives that streamline business operations and drive efficiency. Prior to joining OneDigital, Jayma held key leadership roles at Resourcing Edge, including director of training and development, lead corporate systems trainer, and senior applications specialist. Beyond her professional achievements, Jayma hosts the “What's In a Name?” podcast, pursues her passion for photography, and actively volunteers with the HRACO Workforce Readiness Committee.

OncLive® On Air
S15 Ep39: Novel Targeted Agents Are Poised to Influence MPN Treatment Paradigm: With John O. Mascarenhas, MD

OncLive® On Air

Play Episode Listen Later Jan 29, 2026 13:46


Welcome to OncLive On Air®! OncLive On Air is a podcast from OncLive®, which provides oncology professionals with the resources and information they need to provide the best patient care. In both digital and print formats, OncLive covers every angle of oncology practice, from new technology to treatment advances to important regulatory decisions.In today's episode, we welcomed John O. Mascarenhas, MD, a member of The Tisch Cancer Institute, a professor of medicine at the Icahn School of Medicine, and director of the Center of Excellence for Blood Cancers and Myeloid Disorders at Mount Sinai in New York, New York.In the exclusive interview, Dr Mascarenhas explored novel targeted therapeutic approaches being evaluated in patients with myeloproliferative neoplasms, including myelofibrosis and polycythemia vera. He outlined key reasons for investigating non–JAK inhibitor agents within this treatment paradigm; outlined data from a pair of phase 1 trials (NCT05936359; NCT06034002) evaluating the INCA033989 as monotherapy or in combination with ruxolitinib (Jakafi) in patients with CALR exon 9–mutated myelofibrosis; detailed another ongoing phase 1 study (NCT06313593) looking at INCB160058 in patients with MPNs; and explained how investigational targeted therapies could ultimately impact the MPN treatment paradigm.

The AI Breakdown: Daily Artificial Intelligence News and Discussions

Agent swarms are quickly moving from theory to practice, with early 2026 model releases making coordinated, multi-agent work feel like a real shift rather than a niche experiment. This episode focuses on Moonshot's Kimi K2.5, what its agent swarm design reveals about the future of AI work, and why this may mark a transition from single assistants to teams of AI operating in parallel. In the headlines: Anthropic's huge new funding round and revised revenue forecasts, Nvidia chip sales reopening in China, a UK-wide AI upskilling initiative, and new agentic features from Google and Chinese labs. Brought to you by:KPMG – Discover how AI is transforming possibility into reality. Tune into the new KPMG 'You Can with AI' podcast and unlock insights that will inform smarter decisions inside your enterprise. Listen now and start shaping your future with every episode. ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.kpmg.us/AIpodcasts⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Zencoder - From vibe coding to AI-first engineering - ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠http://zencoder.ai/zenflow⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Optimizely Opal - The agent orchestration platform build for marketers - ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.optimizely.com/theaidailybrief⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠AssemblyAI - The best way to build Voice AI apps - ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.assemblyai.com/brief⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Section - Build an AI workforce at scale - ⁠⁠⁠⁠⁠https://www.sectionai.com/⁠⁠⁠⁠⁠LandfallIP - AI to Navigate the Patent Process - https://landfallip.com/Robots & Pencils - Cloud-native AI solutions that power results ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://robotsandpencils.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠The Agent Readiness Audit from Superintelligent - Go to ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://besuper.ai/ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠to request your company's agent readiness score.The AI Daily Brief helps you understand the most important news and discussions in AI. Subscribe to the podcast version of The AI Daily Brief wherever you listen: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://pod.link/1680633614⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Interested in sponsoring the show? sponsors@aidailybrief.ai

LawNext
From Customer to Acquirer: Filevine's Ryan Anderson and Pincites' Sona Sulakian on Building AI Contract Intelligence

LawNext

Play Episode Listen Later Jan 28, 2026 36:40


In this episode of LawNext, we talk with Ryan Anderson, co-founder and CEO of Filevine, and Sona Sulakian, former CEO and co-founder of Pincites, about Filevine's acquisition of the AI-powered contract redlining company. The deal, which closed in December, marks Filevine's second major AI acquisition of the year. Even more notably for this traditionally litigation-focused company, it represents a significant strategic expansion into the corporate and transactional legal market — a segment where Filevine saw 120% growth in 2025. What makes this acquisition particularly compelling is its origin story: Filevine was actually a customer of Pincites before acquiring the company. After Filevine's legal team became early adopters and enthusiastic users of the product, Anderson and his team recognized that Pincites' Word-native contract intelligence platform filled a critical gap in their offerings. The acquisition brings aboard sister co-founders Sona and Mariam Sulakian and their team, who will continue developing what Filevine now calls "LOIS for Word" — a drafting and redlining tool integrated directly into Microsoft Word. Along with host Bob Ambrogi, they discuss how the Sulakian sisters identified the market gap that led them to build Pincites, why they chose to build directly into Word rather than create a standalone platform, and what attracted them to Filevine among multiple suitors. Anderson shares his vision for building a comprehensive Legal Operating Intelligence System (LOIS) that connects contracts, depositions and all legal work into a single unified platform. They also explore the broader implications of AI for legal practice and access to justice, and how tools like Pincites and Filevine are transforming the way legal work gets done.   Thank You To Our Sponsors This episode of LawNext is generously made possible by our sponsors. We appreciate their support and hope you will check them out.   Paradigm, home to the practice management platforms PracticePanther, Bill4Time, MerusCase and LollyLaw; the e-payments platform Headnote; and the legal accounting software TrustBooks. Briefpoint, eliminating routine discovery response and request drafting tasks so you can focus on drafting what matters (or just make it home for dinner). Legalweek, March 9-12, North Javits Center, New York City.   If you enjoy listening to LawNext, please leave us a review wherever you listen to podcasts.  

Tough Things First
The Assessment Paradigm

Tough Things First

Play Episode Listen Later Jan 28, 2026 7:52


Taken from a page of Ray's book Zen of Zinn 3, in this Tough Things First podcast, Ray Zinn discusses how honest assessment is the difference between gambling and investing. Rob Artigo: Ray, let's turn to page 89 of Zen of Zinn 3, your book in the series of three books. Page 89, and this is what it said, very […]

zen paradigm zinn ray zinn tough things first
Mining Stock Daily
'New paradigm' for metals: Coppernico Metals' Ivan Bebek on why copper can run further

Mining Stock Daily

Play Episode Listen Later Jan 26, 2026 16:24


Ivan Bebek, Founder, Director, Chair, and CEO of Coppernico Metals, joins host Michael McCrae on Mining Stock Daily from the Vancouver Resource Investment Conference to unpack what he calls a “new paradigm” for metals markets. With gold pushing record highs and copper trading near historic levels, Bebek argues the sector is still in the early innings of a powerful, multi-year bull market—particularly for copper.Bebek explains why surging demand from electrification, AI data centers, infrastructure modernization, and electric vehicles is colliding with a tight global copper supply. New discoveries are scarce, existing mines are aging and declining in grade, and building new copper mines now takes decades due to massive capital requirements, social and permitting challenges, and logistical bottlenecks. Money alone, he says, can't solve the problem—time is the real constraint.The conversation also explores why M&A is poised to accelerate as major miners, flush with cash and higher share prices, look to replace depleting reserves. Bebek discusses Coppernico's strategy of chasing higher-grade copper targets and why major miners like Newmont and Teck are already shareholders.Touching on lessons from past bull markets, cost inflation risks, and the importance of grade, Bebek makes a compelling case that copper prices have much further to run—and that discoveries, not capital, will ultimately define the winners in this cycle.

Great Minds: People and Culture
The Data Behind Belonging: What Leaders Get Wrong About Culture — with Carissa Romero, Co-Founder of Paradigm

Great Minds: People and Culture

Play Episode Listen Later Jan 21, 2026 39:07


In this episode, Ren Akinci sits down with Carissa Romero, Ph.D., co-founder of Paradigm, for a conversation about what actually changes behavior at work and what quietly undermines it. Drawing from her roots in Stanford research and years advising leaders, Carissa breaks down why many well-intentioned culture efforts fail, how data often contradicts leadership narratives, and what it really takes to build belonging at scale.   

LawNext
From Roommates to Billionaires: Harvey's Founders Gabriel Pereyra and Winston Weinberg on Building AI Infrastructure for Law

LawNext

Play Episode Listen Later Jan 20, 2026 55:01


Gabriel Pereyra and Winston Weinberg started legal AI company Harvey in 2022 as roommates in a San Francisco apartment. Pereyra had been working on AI research at Meta and Google, while Weinberg was a first-year litigation associate at O'Melveny & Myers. Today, they still share that same apartment, but their company has grown into a global enterprise serving more than 1,000 law firms and corporate legal departments and valued at a whopping $8 billion. In this episode of LawNext, Pereyra and Weinberg take us back to Harvey's earliest days, when they were sending thousands of LinkedIn messages trying to get anyone to look at their product. They share the pivotal moment when early access to GPT-4 transformed what they could build, the breakthrough that came when Allen & Overy became their first major client, and how they have evolved from building an AI assistant for individual lawyers to constructing what they call "essential infrastructure" for legal work. With host Bob Ambrogi, they discuss Harvey's vision for becoming an AI operating system that integrates across the entire legal tech ecosystem, their focus on memory and agentic AI that can handle complex multi-step workflows, and the massive infrastructure challenges of deploying AI at scale across global law firms while maintaining ethical walls and data security.  Pereyra and Weinberg also reflect candidly on how two founders with no management experience have learned to scale a company now employing hundreds of people — more than 20 percent of whom are lawyers — and what it is like to go from struggling startup to being featured in The New York Times as AI billionaires while still sleeping on a mattress on the floor.   Thank You To Our Sponsors This episode of LawNext is generously made possible by our sponsors. We appreciate their support and hope you will check them out.   Paradigm, home to the practice management platforms PracticePanther, Bill4Time, MerusCase and LollyLaw; the e-payments platform Headnote; and the legal accounting software TrustBooks. Briefpoint, eliminating routine discovery response and request drafting tasks so you can focus on drafting what matters (or just make it home for dinner). Eve, taking care of the tasks that slow you down so you can operate at your highest potential   If you enjoy listening to LawNext, please leave us a review wherever you listen to podcasts.  

RV Podcast
RV News Podcast: Tampa Debrief and Sale Rumors

RV Podcast

Play Episode Listen Later Jan 19, 2026 13:46


Hey everybody, welcome to the RV Podcast News Edition for Monday, January 19, 2026. I'm Mike Wendland.This is where we cut through the noise and bring you what's really happening right now in the RV lifestyle and the RV industry. Five stories this week, and taken together they paint a clear picture.The RV world is not just changing. It is restructuring.Let's get started.STORY 1. TAMPA SUPERSHOW AND THE MEGA-DEALERS GET EVEN BIGGERThe Florida RV SuperShow wrapped up this weekend in Tampa, and once again it was the Super Bowl of RVing. Huge crowds, massive inventory, and a lot of signals about where the industry thinks things are headed.One number really stood out.Lazydays RV, now operating as Lazydays RV powered by Campers Inn, announced it brought more than 450 RVs to the show. Four hundred and fifty units on the grounds. There were over 1,300 new models here. That means Lazydays, if it really bought that many uits - I didnt count them - accounted for a third of the total new units on display.That is more than confidence. That is making a statement and claiming market power.It highlights how the biggest RV chains keep getting bigger. Camping World, General RV, Blue Compass, and Campers Inn have all been aggressively buying up smaller dealerships across the country.In many markets, those big names now sit next to each other, or even across the street from one another.That kind of saturation creates brutal competition and raises a serious question. How many stores can a market really support?What we kept hearing in Tampa is that 2026 may be the year underperforming locations start quietly closing.We already saw a preview late in 2025 when Camping World abruptly shut down its store in Escanaba, Michigan.For shoppers, this environment cuts both ways. There is more inventory and more choice, but dealers are under pressure to move aging stock. That pressure can work in your favor, if you negotiate wisely.STORY 2. INFLUENCER FATIGUE. THE MARKETING MODEL IS BREAKING DOWNAnother major theme at the Tampa show had nothing to do with floorplans.Influencer fatigue.By our count, there are now at least 500 so-called RV influencers. Probably more. Anyone with a cellphone camera can claim the title, and many have.For years, manufacturers poured money, free gear, and perks into this system.But saturation has changed everything.Behind the scenes, RV manufacturers and marketing teams are saying the influencer model no longer delivers like it once did. They report being flooded with demands for free RVs, guaranteed commissions, and paid travel just to show up.There are clear signs of a pullback.Winnebago has ended relationships with some influencers. Keystone RV has done the same.The issue is trust. When every product is “the best ever,” audiences stop believing any of it.I overheard it firsthand in Tampa. Outside the influencer building, one man said, “I'd be an influencer too if they gave me free stuff. But since that hasn't happened, I don't trust what any of them say. Free stuff and money can buy anything.”That comment captures the problem perfectly.STORY 3. TARIFFS ARE HAMMERING MANUFACTURERS, AND ROADTREK MAY BE THE HARDEST HITAnother major topic of quiet but intense conversation at the SuperShow was tariffs and the damage they are doing to certain RV manufacturers.Start with Europe.The Italian manufacturer Wingamm has been trying to bring compact Class B style motorhomes into the U.S. market for at least the last four years. At one point, the tariff hit on a Wingamm imported from Italy was estimated at roughly $70,000.That nearly killed the effort.The tariff has since been restructured into a fixed import fee announced in mid-2025, about $9,500 on the Oasi 540.1 and roughly $11,100 on other models. Even so, Wingamm has now turned to crowdfunding to help finance its U.S. market entry.Canada is being hit even harder.Many popular Class B vans sold in the U.S. are built in Canada. Tariffs stack up at every step.A prime example is Leisure Travel Vans.Their Unity models use Mercedes Sprinter chassis and major components built in Germany, shipped to Canada, assembled there, and then exported to the United States. Tariffs apply to the chassis, the imported parts, and the finished vehicle.Industry sources say tariffs alone are adding at least $20,000 to the price of a Leisure Travel Vans motorhome. The new Mercedes Benz model that introduced at the show last week was sticker shock on steroids. It's show price was $272,000. For a B + van. Over a quarter of a million dollars! Yikes. And then there's Class B campervan maker Roadtrek, made in Ontario.Roadtrek's situation may be the most severe.The company has struggled since 2019, following a massive financial scandal involving its previous owners that ended in bankruptcy. Roadtrek is currently owned by a French RV company that took control as part of that restructuring.Since then, Roadtrek has faced repeated Mercedes Sprinter chassis shortages, production disruptions, a weak market, and the loss of key personnel.Most recently, Roadtrek lost its longtime National Sales Manager, Mike Williams, widely known across the industry and to customers as “Canada Mike.” He has now joined Sunshine State RVs in Gainesville, Florida, where some are already calling him “Florida Mike.”That is a significant loss of leadership and visibility for the brand.At Tampa, the buzz was everywhere. Roadtrek is struggling badly, and many insiders believe the company may be for sale again. Nothing official, but the talk was constant and came from dealers, current employees,  and industry veterans.Tariffs are a huge reason for all of this pressure.STORY 4. MORE CONSOLIDATION, MIDWEST AUTOMOTIVE DESIGN LIKELY TO BE SOLDAnd speaking of major brands being in play, we're hearing strong indications of another significant acquisition.Multiple sources tell us that Midwest Automotive Design, a high-end builder of luxury Class B motorhomes on the Mercedes-Benz Sprinter platform, is about to be sold.The buyer, according to what we're hearing, is Alliance RV.Alliance RV was founded in 2019 by industry veterans Ryan and Coley Brady and is best known for its Paradigm line of luxury fifth wheels. The company has built a reputation for high-quality construction and strong customer loyalty.Midwest Automotive Design is a powerhouse in the luxury van segment. It is known for models like the Passage and Luxe Cruiser and has also built private-label vans for Ultimate Toys, Chinook, Holiday Rambler, Fleetwood, and American Coach under the REV Group umbrella.This is not a small boutique operation.If confirmed, this move would signal Alliance's expansion beyond towables into the premium motorized market.It reinforces the larger pattern. The RV industry is entering a major consolidation phase, with strong operators positioning themselves to acquire respected niche brands as costs rise and margins tighten.STORY 5. ZION NATIONAL PARK WILL RESTRICT LARGE RVS ON A KEY ROUTENow an important heads-up for anyone planning a Southwest RV trip.Zion National Park has announced a major change taking effect June 7, 2026.Large vehicles will no longer be allowed to travel through the Zion–Mount Carmel Highway, including the famous tunnel.Vehicles longer than about thirty-five feet, wider than seven feet ten inches, taller than eleven feet four inches, or weighing more than fifty thousand pounds will be prohibited. The long-standing escort system for oversized vehicles is being eliminated.The Park Service says the road was never designed for modern RVs and that safety concerns drove the decision.You can still visit Zion, but many large motorhomes and fifth wheels will need alternate routes or off-site parking.This is a major planning issue for RVers heading west.BONUS STORY. HONDA OFFICIALLY ENTERS THE RV SPACE WITH A LIGHTWEIGHT TRAILERAnd here's one of those moments when we get to say, we told you so. This is a BONUS STORY THIS WEEK.Two episodes ago, we reported that Honda was quietly working on something big in the RV space. Now it's official.Honda has unveiled the Base Station Prototype, an all-new lightweight travel trailer designed by Honda engineers at the company's U.S. research and development centers in Los Angeles and Ohio.This is not a rebadged camper. Honda says the Base Station Prototype brings segment-first innovations that only Honda can deliver.The stated goal is to “democratize outdoor adventures.” In plain English, make RVing accessible to more people.Honda designed the Base Station to be towed by many of the most popular vehicles in America, including crossovers like the Honda CR-V and Toyota RAV4, as well as electric vehicles such as the Honda Prologue and Honda's upcoming 0-Series SUV.That is a major shift.Most lightweight trailers still require full-size trucks or large SUVs. Honda is aiming directly at the millions of households that already own smaller vehicles and have been priced out of RV ownership.Honda also says the Base Station will remain competitively priced in the lightweight travel trailer segment, signaling this is not just a concept vehicle but a serious market entry.If Honda follows through, this could reshape the entry-level RV market in a very big way.And as soon as we can see one in person, you know we'll bring you a full report.CLOSINGAlright. That's this week's RV News Edition of the RV Podcast. For links, documents, and deeper background on every story we covered today, be sure to check the show notes on our website at RVPodcast.com. That's our central hub for everything we do, podcasts, blogs, videos, and our community.You can also leave us a voice message, comment, question, or tip right there on the site. We read them all, and many of them help shape future episodes.And a quick reminder that on February 5, I'll be hosting a live, interactive RV Travel Planning Workshop designed to help you plan smarter trips, avoid costly mistakes, and travel with confidence. You'll find all the details and registration information at RVPodcast.com/workshop.That's your RV Podcast Monday News Edition for Jan. 19, 2026. We'll be back Wednesday with our Stories from the Road RV Podcast. I'm Mike Wendland. Thanks for listening, and until next time, have fun, make friends, and find adventure. Happy Trails.Sources and Further Reading2026 Florida RV SuperShow and Dealer ConsolidationLazydays by Campers Inn Brings Over 450 RVs to Tampa Showhttps://rv-pro.com/news/lazydays-by-campers-inn-brings-over-450-rvs-to-tampa-show/Florida RV Trade Association, Official 2026 Florida RV SuperShow Pagehttps://www.frvta.org/show/florida-rv-supershow/Influencer Fatigue and RV Marketing ShiftWinnebago Industries Corporate News and Investor Updateshttps://investor.winnebagoind.com/Keystone RV Company Official Sitehttps://www.keystonerv.com/Tariffs and Cross-Border RV Industry ImpactRV Dealers Association of Canada Update on Counter Tariffshttps://rvbusiness.com/rvda-canada-gives-update-on-counter-tariffs-on-u-s-rvs/How Tariffs Could Impact the RV Industryhttps://www.rv.com/rv/how-tariffs-could-impact-the-rv-industry/Canadian RV Association Statement on U.S.–Canada Tariff Impacthttps://www.rvnews.com/crva-issues-update-on-u-s-canada-tariff-impact/Class B Forum Discussion on Canadian Tariffshttps://www.classbforum.com/threads/canadian-tariffs.654811/Wingamm European Import TariffsWingamm Official Websitehttps://wingamm.com/Wingamm Oasi 540.1 Model Pagehttps://wingamm.com/en/oasi-540-1/Invest in W Motorhome Sales North America (equity crowdfunding on StartEngine)https://www.startengine.com/offering/wmotorhomeLeisure Travel Vans Tariff ExposureLeisure Travel Vans Official Websitehttps://leisurevans.com/Mercedes-Benz Sprinter Global Production Informationhttps://www.mbvans.com/en/sprinter/Roadtrek Company BackgroundCourt-Ordered Receivership for Erwin Hymer Group North America (which included Roadtrek)https://rvldealernews.com/the-court-appointed-receivership-auction-of-erwin-hymer-group-north-america-will-begin-on-tuesday-july-16-and-continue-until-friday-july-19-2019/How Rapido Group Plotted the Rebirth of Roadtrek https://rv-pro.com/features/how-rapido-plotted-rebirth-roadtrek/ Roadtrek Motorhomes Official Websitehttps://roadtrek.com/Alliance RV and Midwest Automotive Design PurchasAlliance RV Official Websitehttps://www.alliancerv.com/Midwest Automotive Design Official Websitehttps://midwestautomotivedesign.com/Midwest Automotive Design About Us Pagehttps://www.midwestautomotivedesign.com/about-us/Midwest Automotive Design Luxe Cruiser Modelhttps://www.midwestautomotivedesign.com/luxury-vans/luxe-cruiser/REV Group Brand Portfoliohttps://www.revgroup.com/our-brands/Zion National Park Large RV RestrictionsZion National Park to Restrict Large Vehicles on Zion–Mount Carmel Highway Beginning June 7, 2026https://www.nationalparkstraveler.org/2026/01/zion-national-park-restrict-large-vehicles-traveling-zion-mt-carmel-highwayZion to Ban Most Large RVs on Mount Carmel Highwayhttps://www.thetraveler.org/zion-to-ban-most-large-rvs-on-mount-carmel-highway-june-7-2026/Honda Enters the RV Market with the Base Station PrototypeHonda Press Release, Honda Unveils Base Station Prototypehttps://hondanews.com/en-US/honda-automobiles/releases/honda-unveils-base-station-prototype-a-lightweight-towable-travel-trailer-with-modular-design-smart-technology-clever-packaging-to-democratize-campingRV Business, Honda Unveils Prototype Base Station Lightweight Camperhttps://rvbusiness.com/honda-unveils-prototype-base-station-lightweight-camper/The Drive, Honda's Secret Project, A Futuristic Camper Trailer You Can Tow With a CR-Vhttps://www.thedrive.com/news/hondas-secret-project-a-futuristic-camper-trailer-you-can-tow-with-a-cr-v

inControl
ep40 - Jeff Shamma: gain scheduling, nonlinear control, learning & dissipativity in games, jiu-jitsu

inControl

Play Episode Listen Later Jan 15, 2026 131:12


Outline00:00 - Intro03:18 - Early days: why control, M. Athans, and IDSS12:21 - What is gain scheduling?33:37 - Paradigm shifts & the ‘90s: Minnesota → Texas → LA 42:19 - Robustness & fundamental limitations of nonlinear systems57:35 - Set-valued control & estimation01:04:52 - Game theory & multi-agent control 01:28:18 - Learning & dissipativity in games & multi agent AI01:45:03 - KAUST: building something new01:53:33 - On human-algorithmic interaction01:59:07 - Advice to future students: control, jiu-jitsu, and chatbots in education2:10:02 - OutroLinksJeff's website: https://tinyurl.com/52btmmz7CSM interview: https://tinyurl.com/49wh98x7Domain: feedbackcontrol.comM. Athans: https://tinyurl.com/nhbw66waPhD thesis: https://tinyurl.com/5eyxkfm6IDSS: https://tinyurl.com/bdenwy6dResearch on gain scheduling: https://tinyurl.com/55se8zcr Overview of LPV systems: https://tinyurl.com/3ksff58b Åström's lecture: https://tinyurl.com/33mxkkfe Necessity of the small gain theorem: https://tinyurl.com/mjn9eeb4 Sensitivity reduction for nonlinear plants: https://tinyurl.com/23tej5ypRespect the unstable: https://tinyurl.com/3yww5eds Differential inclusion: https://tinyurl.com/4yvc8vccLectures on game theory: https://tinyurl.com/4z8hh3rnDynamic fictitious play: https://tinyurl.com/yc6wsxjjCooperative control and potential games: https://tinyurl.com/4hbmrt72Dissipativity theory in game theory: https://tinyurl.com/3theyc7xPopulation games, stable games, and passivity: https://tinyurl.com/zxwtzv6wGame theory and control: https://tinyurl.com/yencrwm3Higher-order uncoupled learning: https://tinyurl.com/37Support the showPodcast infoPodcast website: https://www.incontrolpodcast.com/Apple Podcasts: https://tinyurl.com/5n84j85jSpotify: https://tinyurl.com/4rwztj3cRSS: https://tinyurl.com/yc2fcv4yYoutube: https://tinyurl.com/bdbvhsj6Facebook: https://tinyurl.com/3z24yr43Twitter: https://twitter.com/IncontrolPInstagram: https://tinyurl.com/35cu4kr4Acknowledgments and sponsorsThis episode was supported by the National Centre of Competence in Research on «Dependable, ubiquitous automation» and the IFAC Activity fund. The podcast benefits from the help of an incredibly talented and passionate team. Special thanks to L. Seward, E. Cahard, F. Banis, F. Dörfler, J. Lygeros, ETH studio and mirrorlake . Music was composed by A New Element.

LawNext
Clio Doubleheader: CMO Reagan Attle and VP of Payments A.J. Axelrod

LawNext

Play Episode Listen Later Jan 14, 2026 40:56


In the last in a series of interviews recorded during the ClioCon conference in Boston in October 2025, we bring you a doubleheader – two interviews with two of the legal tech company's key executives.  In the first, LawNext host Bob Ambrogi speaks with Reagan Attle, chief marketing officer at Clio since 2017. In a year in which Clio made the biggest acquisition in legal tech history with its $1 billion purchase of vLex, and in which Clio is aiming to dramatically expand its market and its use of AI, what are the challenges and opportunities for the person tasked with leading the company's global brand and marketing strategy? One thing for sure, Attle says: It makes her job more complex. Listen to the interview to hear Attle's perspective.  In the second interview, Ambrogi sits down with A.J. Axelrod, who joined Clio in November 2024 as vice president of payments and financial services. He fills us in on the two financial products unveiled at ClioCon: Clio Capital, a capital-advance program offering law firms fast access to funds for growth or cash-flow management, and Pay Later, a financing option for law firm clients to pay their legal bills in installments, while the firm gets paid up front. He also talks about what else may be on the horizon for fintech at Clio.   Thank You To Our Sponsors This episode of LawNext is generously made possible by our sponsors. We appreciate their support and hope you will check them out. Paradigm, home to the practice management platforms PracticePanther, Bill4Time, MerusCase and LollyLaw; the e-payments platform Headnote; and the legal accounting software TrustBooks. Briefpoint, eliminating routine discovery response and request drafting tasks so you can focus on drafting what matters (or just make it home for dinner). Eve, taking care of the tasks that slow you down so you can operate at your highest potential   If you enjoy listening to LawNext, please leave us a review wherever you listen to podcasts.  

ai payments paradigm double header axelrod bob ambrogi ambrogi headnote practicepanther lawnext
The Compete Mentality
Perspective Paradigm | 3 Questions to Shift your Perspective

The Compete Mentality

Play Episode Listen Later Jan 14, 2026 9:45


Mindset Guru and NBA/WNBA Trainer Jordan Delks discusses the power of perspective! He poses three great questions to help you align with God's promises instead of our human limitations. The Perspective Paradigm in today's episode is a cheat code to make a shift this week. Tap in today to level up your mindset!

Real Estate Insiders Unfiltered
Agent Series 20: Inside the Rise of Compass: A Founding Agent's Story

Real Estate Insiders Unfiltered

Play Episode Listen Later Jan 12, 2026 52:58


From $61M deals to $0 paydays, NYC real estate is not for the faint of heart. In this episode, James and Keith sit down with Scott Hustis, co-founder of Paradigm Advisory at Compass, to talk about how he built one of New York's top-performing real estate teams; one relationship at a time. Scott shares why he runs his team more like a wealth advisory firm than a brokerage, how he built a repeat-and-referral machine in one of the most cutthroat markets in the world, and why most agents simply aren't consistent enough to succeed. Plus, hear: The 9-year story behind his $61M Central Park sale What the "three-phase" marketing plan really looks like in NYC His thoughts on off-market listings, Zillow, and MLS politics The power of mentors, coaches, and long-term compounding If you're burned out, tempted to shortcut the process, or unsure how to build a sustainable business, this is a masterclass in patience, precision, and real trust-building. Give your clients the competitive edge with Zillow's Showcase. Discover how this exclusive, immersive media experience—featuring stunning photography, video, virtual staging, and SkyTour—helps agents drive more views, saves, and shares. Agents using Showcase on the majority of their listings on Zillow list 30% more homes than similar non-Showcase agents. Learn how to stand out and become the agent sellers choose.   https://www.zillow.com/agents/showcase/   Connect with Scott on LinkedIn.   Learn more about Paradigm on Instagram - LinkedIn and online Paradigm Website, Paradigm Advisory Video. Subscribe to Real Estate Insiders Unfiltered on YouTube! https://www.youtube.com/@RealEstateInsidersUnfiltered?sub_confirmation=1   To learn more about becoming a sponsor of the show, send us an email: jessica@inman.com You asked for it. We delivered. Check out our new merch! https://merch.realestateinsidersunfiltered.com/   Follow Real Estate Insiders Unfiltered Podcast on Instagram - YouTube, Facebook - TikTok. Visit us online at realestateinsidersunfiltered.com.   Link to Facebook Page: https://www.facebook.com/RealEstateInsidersUnfiltered Link to Instagram Page: https://www.instagram.com/realestateinsiderspod/ Link to YouTube Page: https://www.youtube.com/@RealEstateInsidersUnfiltered Link to TikTok Page: https://www.tiktok.com/@realestateinsiderspod Link to website: https://realestateinsidersunfiltered.com This podcast is produced by Two Brothers Creative. https://twobrotherscreative.com/contact/  

My Human Design
Getting Rid of our Fears and Shadows

My Human Design

Play Episode Listen Later Jan 9, 2026 25:46


The Paradigm may be changing around us but Life's main concern is that the paradigm INSIDE us shifts. Otherwise the world outside will see the change but our experience of it won't be any better. It's our consciousness that we inject into life that will make the next era great- or not. This is a clarion call to be radical and ruthless about shedding all the inner fears and shadows that lead our actions and choices astray. That creates all the behaviours we are sick of and want to leave behind. I really pray for you, me, and us to rise above and out of these thoughts that just aren't real, because we deserve it and our world deserves it. Here's to our Rising.Download the 'Align: The Human Design App' in the App Store and on Google PlayGet your free Human Design Chart on our website www.myhumandesign.comTo follow us on Instagram click HERETo connect with Jenna Zoe click HERE

The Bike Shed
488: The Playful Portland Programming Paradigm

The Bike Shed

Play Episode Listen Later Jan 6, 2026 30:47


Aji and Joël talk all things hackerthons and why taking the time to have a little having fun with your work every now and then is important for developers. Our hosts reflect on their shared experience at a previous RailsConf where they entered a mini hackerthon, why playing around in a creative sandbox is crucial to honing your skills as a dev, and how programming on the fly can teach you a lot about your own strengths and weaknesses. — Read more about Joël's entry in Rails Rumble (https://thoughtbot.com/blog/rails-rumble-roundup), as well as their participation in the RailsConf 2022 mini Hackerthon (https://thoughtbot.com/blog/thoughtbot-presentations-good-vibes-from-railsconf-2022). Thanks to our sponsors for this episode Judoscale - Autoscale the Right Way (https://judoscale.com/bikeshed) (check the link for your free gift!), and Scout Monitoring (https://www.scoutapm.com/). Your hosts for this episode have been thoughtbot's own Joël Quenneville (https://www.linkedin.com/in/joel-quenneville-96b18b58/) and Aji Slater (https://www.linkedin.com/in/doodlingdev/). If you would like to support the show, head over to our GitHub page (https://github.com/sponsors/thoughtbot), or check out our website (https://bikeshed.thoughtbot.com). Got a question or comment about the show? Why not write to our hosts: hosts@bikeshed.fm This has been a thoughtbot (https://thoughtbot.com/) podcast. Stay up to date by following us on social media - YouTube (https://www.youtube.com/@thoughtbot/streams) - LinkedIn (https://www.linkedin.com/company/150727/) - Mastodon (https://thoughtbot.social/@thoughtbot) - BlueSky (https://bsky.app/profile/thoughtbot.com) © 2025 thoughtbot, inc.

The Reality Revolution Podcast
Breaking The Earning Paradigm - The Activation of Pure Receiving

The Reality Revolution Podcast

Play Episode Listen Later Jan 5, 2026 33:47


Join for a live in person event in Newark New Jersey on February 27 through March 1st https://www.brianscottlive.com/february-2026 Join The Reality Revolution Tribe