Podcasts about Paradigm

“Dying for Access”

Recently, the legal technology company Case Status held its inaugural Client Experience Summit in Charleston, S.C., a conference devoted to exploring how AI, data and ethical practices can enable law firms to deliver a better experience for their clients.In an opening keynote at the conference, Andy Seavers, the cofounder and CEO of Case Status, unveiled several new products, including, most notably, Client Intelligence, an AI-driven platform that the company says represents a significant shift for law firms from reactive client management to predictive client engagement. Shortly after Seavers delivered that keynote, LawNext host Bob Ambrogi, who attended the conference, sat down with him for this interview to learn more about the company and its latest announcements. When Case Status first launched, it was often described as the Dominos pizza tracker for law, insofar as it enabled clients to easily keep track of the status of their case. As you'll hear from Seavers in today's interview, it has expanded significantly since then, into a full client experience and client intelligence platform. Also in today's interview, Seavers discusses his just-published a book, Future Firm, Fossil Firm, in which he lays out a blueprint for how law firms can evolve. He discusses his vision of a “future firm,” and why he believes that leadership posture, operational systems, and client experience are now the defining factors of firm success.   Thank You To Our Sponsors This episode of LawNext is generously made possible by our sponsors. We appreciate their support and hope you will check them out.   Paradigm, home to the practice management platforms PracticePanther, Bill4Time, MerusCase and LollyLaw; the e-payments platform Headnote; and the legal accounting software TrustBooks. Briefpoint, eliminating routine discovery response and request drafting tasks so you can focus on drafting what matters (or just make it home for dinner). Eve, taking care of the tasks that slow you down so you can operate at your highest potential   If you enjoy listening to LawNext, please leave us a review wherever you listen to podcasts.  

Jason and Paul welcome public radio host (and Pearl Jam super-fan) Kyle Meredith back to the show to discuss the new public radio landscape since President Trump had congress defund the Corporation for Public Broadcasting. Now PBS, NPR and around 1,000 affiliates are without federal dollars that will drastically affect those stations...if not outright put take them off the air. Many Americans get their news and curated music from these media...so now what? Kyle offers his insight. Plus Kyle reacts to the recent Matt Cameron and Stone Gossard interviews.Please considering donating to our October 2025 fundraiser benefitting The Arc HEREBuy Pod MerchBecome a PatronWatch Us on YouTubeFollow Us on InstagramFollow Us on FacebookFollow Us on TwitterPlease a short survey HERE to help us better the show! Hosted on Acast. See acast.com/privacy for more information.

Across the country, proficiency is sliding and absenteeism is climbing, yet there is a practical path that moves the needle. In this episode of Change Starts Here, host Dustin Odham makes a case for student ownership as the missing engine behind academic improvement, engagement, and long term readiness. Dustin connects national context to daily classroom reality, then shows what ownership actually looks like, students tracking goals, reflecting on data, leading discussions, and taking the mic in conferences with families. He explains why even small shifts can spark big belief, and why strategies do not stick without a culture that invites students to lead their own learning. If you are a district leader, principal, or teacher who wants higher engagement and better results, let your students run the classroom, and see how they take off.Host: Dustin OdhamTimestamps: (00:00 - 00:24) Open and setup. (00:24 - 01:08) The problem, proficiency and real world stakes. (01:08 - 01:56) Why it matters, college, STEM, equity. (01:56 - 02:25) Absenteeism scale and urgency. (02:25 - 02:57) Paradigm shift, from academics only to ownership. (02:57 - 03:27) Research lens, Hattie and Dweck. (03:27 - 04:18) Culture first, strategies do not stick without it. (04:18 - 05:10) What ownership looks like in practice. (05:10 - 05:34) Ripple effects, attendance, engagement, academics. (05:34 - 06:05) Beyond school, workforce and citizenship. (06:05 - 06:44) Early adopters and encouragement. (06:44 - 07:38) Calls to action, district, principal, teacher moves. (07:38 - 08:05) Small shifts that spark ownership. (08:05 - 08:32) Instruction plus empowerment, partnership mindset. (08:32 - 09:25) Subscribe, share, and season vision. (09:25 - 09:44) Outro.

Across the country, proficiency is sliding and absenteeism is climbing, yet there is a practical path that moves the needle. In this episode of Change Starts Here, host Dustin Odham makes a case for student ownership as the missing engine behind academic improvement, engagement, and long term readiness. Dustin connects national context to daily classroom reality, then shows what ownership actually looks like, students tracking goals, reflecting on data, leading discussions, and taking the mic in conferences with families. He explains why even small shifts can spark big belief, and why strategies do not stick without a culture that invites students to lead their own learning. If you are a district leader, principal, or teacher who wants higher engagement and better results, let your students run the classroom, and see how they take off.Host: Dustin OdhamTimestamps: (00:00 - 00:24) Open and setup. (00:24 - 01:08) The problem, proficiency and real world stakes. (01:08 - 01:56) Why it matters, college, STEM, equity. (01:56 - 02:25) Absenteeism scale and urgency. (02:25 - 02:57) Paradigm shift, from academics only to ownership. (02:57 - 03:27) Research lens, Hattie and Dweck. (03:27 - 04:18) Culture first, strategies do not stick without it. (04:18 - 05:10) What ownership looks like in practice. (05:10 - 05:34) Ripple effects, attendance, engagement, academics. (05:34 - 06:05) Beyond school, workforce and citizenship. (06:05 - 06:44) Early adopters and encouragement. (06:44 - 07:38) Calls to action, district, principal, teacher moves. (07:38 - 08:05) Small shifts that spark ownership. (08:05 - 08:32) Instruction plus empowerment, partnership mindset. (08:32 - 09:25) Subscribe, share, and season vision. (09:25 - 09:44) Outro.

Pastor Chad digs deep into Romans 3 and reminds us of the weight of sin and the beauty of the gospel. ✨ Paul shows us that we all fall short—none of us are righteous on our own. Sin isn't just something we stumble into; it's what we naturally choose. But the good news is that God, in His justice, doesn't leave us there.

What if your business, team, or even your personal work rhythm could actually grow because of friction — not in spite of it? That's the question we dig into with today's guest, Travis Lee Howard, as he shares his powerful framework called the Mindful Business Paradigm (MVP).  This isn't just another business model — it's a way to diagnose where things are off, whether you're a leader, creator, or changemaker trying to do mission-minded work that actually matters. Travis breaks down the four-part paradigm — Self → Customer → Machine → Team — and helps us understand how misalignment between any of these areas can derail your impact.  But with the right questions and reframes, you can find your way back to clarity, connection, and creativity.

Nearly two years ago on this podcast, we discussed the American Arbitration Association's innovation initiatives – and specifically its embrace of generative AI – with Bridget Mary McCormack, who became its president and CEO in 2023 after having been chief justice of the Michigan Supreme Court, and Diana Didia, its chief information and innovation officer. On today's episode, McCormack and Didia – now executive vice president and chief technology and innovation officer – return for an update on innovation at the AAA.    In that prior podcast, McCormack and Didia spoke extensively about the AAA's innovation culture and their early experiments with gen AI. At the time, McCormack said that anyone who thinks they know where gen AI is going, even next week, is fooling themselves. While that may still be true, the AAA has certainly made some bold moves in that direction. Most notably, just a few days before we recorded this episode, the AAA announced something unprecedented in the dispute resolution world – an AI-powered arbitrator that it is launching in November. This is not just another AI tool to assist lawyers or arbitrators. This is an AI system that will evaluate case merits, generate recommendations, and prepare draft awards — with human arbitrators validating and signing off on final decisions before they are issued. In today's conversation with host Bob Ambrogi, McCormack and Didia dive deep into how this AI arbitrator works, what it means for the future of dispute resolution, and how it fits into the AAA's broader innovation strategy as the organization approaches its 100th anniversary next year. They also explore the cultural transformation within the AAA that has enabled these technological advances and what is coming next in their AI-native vision for dispute resolution.  Related episodes: On the latest LawNext: Sociologist Rebecca Sandefur on Enhancing Access to Justice. On LawNext: How A New Kind of Justice Worker Could Narrow the Justice Gap, with Nikole Nelson, CEO of Frontline Justice.  On LawNext: CEO Nikole Nelson Returns with An Update on Frontline Justice's Mission to Empower Justice Workers and Bridge the Justice Gap. Thank You To Our Sponsors This episode of LawNext is generously made possible by our sponsors. We appreciate their support and hope you will check them out.   Paradigm, home to the practice management platforms PracticePanther, Bill4Time, MerusCase and LollyLaw; the e-payments platform Headnote; and the legal accounting software TrustBooks. Briefpoint, eliminating routine discovery response and request drafting tasks so you can focus on drafting what matters (or just make it home for dinner). Paxton, Rapidly conduct research, accelerate drafting, and analyze documents with Paxton. What do you need to get done today?    If you enjoy listening to LawNext, please leave us a review wherever you listen to podcasts.  

This episode features a powerful discussion with Dr. Padma Mahant, Director of Medical Affairs, CND Life Sciences, and Dr. Indu Subramanian, a Neurologist with UCLA, who are leading the charge to correct the biases in Parkinson's disease care. They expose a critical gap where women's unique, non-motor symptoms are often overlooked, resulting in twice as many women waiting five or more years for a proper diagnosis compared to men. The conversation highlights the imperative to move beyond the "cookie-cutter" approach by leveraging new, objective diagnostic tools to aid early detection, prioritizing women's inclusion in clinical research, and adopting a compassionate, integrative model that places the patient at the center of their own wellness journey. This podcast is not available for CME/CE/CPD credits. Please visit the Medscape homepage for accredited CME/CE/CPD activities. https://www.medscape.org/viewarticle/1002954

Week 5 in the Big Ten was loaded with drama, and Big Ten Paradigm breaks it all down. Noah Drury recaps Oregon's thrilling double-overtime win at Penn State, Illinois' physical upset of USC, and Indiana's continued rise behind quarterback Fernando Mendoza. Plus, Ohio State shook off a slow start to beat Washington, while Minnesota and Rutgers battled to the final kick. We also look at Northwestern's surprising win over UCLA and how the AP Top 25 stacks up heading into Week 6. With Michigan–Wisconsin looming and key matchups across the league, this episode delivers insights you won't want to miss.This episode is sponsored in part by TicketSmarter:Use promo code LWOS10 to receive $10 off purchases of $100 or moreUse promo code LWOS20 to receive $20 off purchases of $300 or moreThink smarter.  TicketSmarter

Good Lies We Believe

How to Identify and Rewire the Subconscious "Software" That Runs Your Life   This episode of the Rich Mind Podcast is a follow-up and deeper dive into one of the most powerful forces shaping our lives: our paradigms. Randy and his daughter Adrienne return to dissect the "mental software" we're programmed with from a young age. They discuss how these deep-seated beliefs, often formed before we can even reason, act as a filter that dictates our reactions, creates emotional triggers, and reinforces core wounds like not feeling "lovable" or "worthy." Through personal stories and real-time analysis, they explore how to become aware of this programming, challenge the "black and white" thinking it creates, and reclaim control over your own thoughts, feelings, and actions. This conversation is a practical guide to identifying your own paradigm and beginning the work of rewriting it.   Key Takeaways:   Your paradigm is the subconscious "software" programmed into you during your formative years (ages 0-8) that controls most of your automatic behaviors and beliefs. This mental program acts as a "safety shield," creating emotional triggers to keep you within your comfort zone and away from perceived threats. Many of our deepest struggles and limiting beliefs stem from stories we created in childhood to make sense of events, even if those stories aren't true. The first step to changing your paradigm is awareness: recognizing a trigger in the moment and questioning where the feeling is coming from. We are not our feelings. Separating your identity from your emotions (e.g., saying "I am feeling sad" instead of "I am sad") is a powerful technique to regain control. A powerful mantra to release the need for external validation is: "What's meant for me will find me, and anything else is none of my business." It's never too early and never too late to start the work of understanding and rewriting your own paradigm.   Questions Answered in This Episode:   What is a paradigm and how does it control your daily life? How does our childhood programming affect our adult relationships and success? How are emotional triggers connected to our core wounds and paradigm? How can you become more aware of your own paradigm in real-time? Why do we often feel like we can't put our negative feelings into words? What is the danger of using "I am" statements when describing negative emotions? How can you stop caring about what others think and stay focused on your own path? What practical steps can you take to begin changing your deep-seated programming?   Key People, Concepts, & Terms:   People: Randy Wilson, Adrienne Wilson, Bob Proctor. Concepts: Paradigm, Subconscious Mind, Software/Filter Analogy, Core Wounds (Not Lovable/Worthy), Triggers, Black and White Thinking, I Am Statements, Self-Awareness, Personal Development, Journaling.   Key Episode Timestamps   00:00 - Introduction: Going Deeper into the Concept of Paradigms 02:16 - What is a Paradigm? The "Software" Programmed in Our Formative Years 03:00 - How Your Paradigm Creates a "Safety Shield" and Core Wounds 04:58 - A Real-Life Example: You Are the Sum of the 5 People You Spend Time With 06:28 - Why We Can't Always Put Our Feelings Into Words (The Subconscious Takes Over) 08:32 - What Do Your Triggers Look Like? (Quiet & Distant vs. Emotional) 12:23 - Randy's Story: Unpacking Childhood Triggers and the Need to Be Liked 18:10 - Adrienne's Story: Dealing with the "Wilson Kids" Reputation and Forging Her Own Identity 23:14 - Actionable Technique: Separating Your Feelings From Your Identity ("I Am Feeling...") 30:43 - One Step Forward is Still Forward: Progress Over Perfection 34:38 - Practical Tools: Journaling and Voice Memos to Get Your Paradigm "Out"

Good Lies We Believe

How can the church create safe spaces for healing from pornography and sexual brokenness? In this powerful conversation, Nick Stumbo from Pure Desire Ministry joins hosts Karen Potter and Rob Stoddard to talk about shame, recovery, and the hope of freedom in Christ.In this episode of The Covenant Eyes Podcast, Karen Potter and Rob Stoddard sit down with Nick Stumbo, Executive Director of Pure Desire Ministry. Together, they explore how the church can respond to pornography and sexual addiction with grace, truth, and community.Nick shares his personal story of transformation and how Pure Desire provides resources, small groups, and counseling to help men, women, and couples find lasting freedom. The discussion covers:• Why shame keeps people silent and how churches can break that barrier• The importance of shifting our language from “you” to “we” when addressing sexual struggles• How generational differences impact views on pornography• Why both men and women need healing from sexual brokenness• Practical steps for pastors and church leaders to start recovery groups• How Pure Desire partners with Covenant Eyes to equip families and churches

About Dr. Ivan Misner:Dr. Ivan Misner is the Founder & Chief Visionary Officer of BNI, the world's largest business networking organization. Founded in 1985, the organization now has over 11,100 chapters in 76 countries throughout every populated continent of the world. Last year alone, BNI generated 15.1 million referrals, resulting in more than 23.3 billion dollars' worth of business for its members.Dr. Misner's Ph.D. is from the University of Southern California. He is a New York Times Bestselling author who has written 29 books, including his newest – The 3rd Paradigm, A Radical Shift to Greater Success. He is also a columnist for Entrepreneur.com and has been a university professor at several universities as well as a member of the Board of Trustees for the University of La Verne.Called the “Father of Modern Networking” by both Forbes and CNN, Dr. Misner is considered to be one of the world's leading experts on business networking and has been a keynote speaker for major corporations and associations throughout the world. He has been featured in the L.A. Times, Wall Street Journal, and New York Times, as well as numerous TV and radio shows, including CNN, the BBC, and The Today Show on NBC. In this episode, Jennie Bellinger and Dr. Ivan Misner discuss:The remarkable journey and growth of BNI and its impact on direct sales professionalsThe burgeoning influence of networking for generating valuable referrals and its significance in marketingThe underlying principles of successful direct sales strategies and the importance of relationship-buildingThe concept of 'Infinite Giving' and the transformative 'Givers Gain' philosophy within business contextsThe evolving business dynamics from competition to cooperation and ultimately to co-creation Key Takeaways:The podcast emphasizes the critical role of networking in direct sales success, with Jennie Bellinger providing valuable techniques and tips through conversations with industry leaders like Dr. Ivan Misner.Dr. Ivan Misner's journey with BNI illustrates the tremendous potential of structured networking, highlighting how precise articulation of products and services can lead to effective referrals and significant business growth.Misner advocates for integrating BNI's relationship-building methodologies and consistent, purpose-driven tactics, emphasizing the 'Givers Gain' principle as a transformative professional approach.The concept of 'Infinite Giving' is explored, encouraging a shift from competition to co-creation, with insights from Misner's upcoming book on leaving a lasting legacy and maintaining a clear business vision.The podcast equips direct sales professionals with Misner's wisdom on vision clarity and resilience, guiding them to navigate and excel in the network marketing landscape. "Networking is less about who you know, and more about who trusts you.” — Dr. Ivan Misner Join our growing “What You Need to Grow Podcast Community”Link: https://www.facebook.com/groups/756666570494461  Connect with Dr. Ivan Misner:  Facebook: https://www.facebook.com/ivan.misner   Instagram: https://www.instagram.com/drivanmisner/  LinkedIn: https://www.linkedin.com/in/ivanmisner/Ivan's Free Blog: https://ivanmisner.com/blog  BNI website: https://bni.com  Find and visit a BNI chapter near you!Connect with Jennie:Website: https://badassdirectsalesmastery.com/Email: jennie@badassdirectsalesmastery.comFacebook personal page: https://facebook.com/jbellingerPLFacebook podcast page: http://facebook.com/BadassDirectSalesMasteryFacebook group for Badass Crew: https://facebook.com/groups/BadassDirectSalesMomsInstagram: https://instagram.com/BadassDirectSalesMasteryPersonal Instagram: https://www.instagram.com/thedirectsalesdomme/LinkedIn: https://linkedin.com/in/BadassDirectSalesMasteryThe Badass Direct Sales Mastery Podcast is currently sponsored by the following:Bella Grace Elixir: https://shopbellagrace.com/?ref=jenniebadassdirectsalesmasteryLeadBuddy Digital Marketing: Use code BDSM when checking out at https://leadbuddy.io/pro-monthly-9310?am_id=jennie582Show Notes by Podcastologist: Hanz Jimuel Alvarez Audio production by Turnkey Podcast Productions. You're the expert. Your podcast will prove it. 

With as many as 120 million legal problems going unresolved in America each year, traditional lawyer-centered approaches to access to justice have consistently failed to meet the scale of need. But what if the solution is not just about providing more legal services — what if it lies in fundamentally rethinking who can provide legal help? In today's episode, host Bob Ambrogi is joined by two of the nation's leading researchers on access to justice: Rebecca Sandefur, professor and director of the Sanford School of Social and Family Dynamics at Arizona State University and a faculty fellow at the American Bar Foundation, and Matthew Burnett, director of research and programs for the Access to Justice Research Initiative at the American Bar Foundation and an adjunct professor of law at Georgetown University Law Center.  They argue that the access to justice crisis is actually a crisis of democracy. As cofounders of Frontline Justice, they have been pioneering research on "justice workers" — community members trained to help their neighbors navigate legal issues. Their recent article in the South Carolina Law Review, “Justice Work as Democracy Work: Reimagining Access to Justice as Democratization,” makes a provocative case: When people cannot access their own law, democracy itself fails. They present compelling evidence from Alaska, where nearly 200 community justice workers now serve over 40 rural communities, achieving a 1-to-25 return on investment while dramatically expanding legal aid's reach. In today's conversation, Sandefur and Burnett discuss the mounting evidence for justice worker effectiveness, including research from the U.K. demonstrating that trained non-lawyers often outperform attorneys on specialized tasks. They also discuss recent breakthroughs — including unprecedented support from both the Conference of Chief Justices and the American Bar Association — and examine what obstacles remain.  Sandefur and Burnett challenge the legal profession's monopoly on law, arguing that regulatory capture has estranged Americans from their own justice system. They envision justice workers as agents of democratization, expanding not just who can access legal help, but who can participate meaningfully in working democracy.  Related episodes: On the latest LawNext: Sociologist Rebecca Sandefur on Enhancing Access to Justice. On LawNext: How A New Kind of Justice Worker Could Narrow the Justice Gap, with Nikole Nelson, CEO of Frontline Justice.  On LawNext: CEO Nikole Nelson Returns with An Update on Frontline Justice's Mission to Empower Justice Workers and Bridge the Justice Gap.   Thank You To Our Sponsors This episode of LawNext is generously made possible by our sponsors. We appreciate their support and hope you will check them out. Paradigm, home to the practice management platforms PracticePanther, Bill4Time, MerusCase and LollyLaw; the e-payments platform Headnote; and the legal accounting software TrustBooks. Briefpoint, eliminating routine discovery response and request drafting tasks so you can focus on drafting what matters (or just make it home for dinner). Paxton, Rapidly conduct research, accelerate drafting, and analyze documents with Paxton. What do you need to get done today?    If you enjoy listening to LawNext, please leave us a review wherever you listen to podcasts.  

In this episode of Big Ten Paradigm, Noah Drury recaps all the action from Week 4, including Iowa's offensive surge, Michigan's ground-game dominance, and Indiana's shocking 53-point win over Illinois. Zach Browning of The Hoosier joins the show to provide insight into Indiana's breakout performance, highlighting quarterback Fernando Mendoza's NFL potential and the Hoosiers' disruptive defense. The conversation also looks ahead to a massive slate of upcoming games, including Indiana's trip to Iowa and the showdown between Oregon and Penn State. This episode is sponsored in part by TicketSmarter:Use promo code LWOS10 to receive $10 off purchases of $100 or moreUse promo code LWOS20 to receive $20 off purchases of $300 or moreThink smarter.  TicketSmarter

El espacio necesita un método de transporte espacial que permita retornar a la Tierra, y eso es lo que han creado Franccesco Cacciatore, confundador y director ejecutivo y tecnológico de Orbital Paradigm, junto a Víctor Gómez, director de operaciones e ingeniero de sistemas de la misma empresa. Orbital Paradigm ofrece sus furgonetas espaciales, o siendo más precisos, sus cápsulas donde llevan laboratorios y luego los devuelven a la Tierra. Este es uno de sus servicios, pero están seguros que la demanda de sus clientes aumentará porque el futuro de la humanidad depende de la conquista del espacio. 

Virgo New Moon Solar Eclipse Themes Eclipse as a fated turning point, clearing clutter, and creating space. Virgo's invitation: refinement of daily practices, devotion to detail as spiritual foundation. Yearly cycle context: closing out a “9 year” to prepare for a “1 year” of new beginnings. Planetary Movements & Aspects Venus in Virgo + Mercury in Libra in mutual reception → collaboration, beauty, balance, and reciprocity. Saturn in Pisces opposition → introspection, emotional closure, ceremony for endings. South Node in Virgo & North Node in Pisces → practical lineage vs. surrender and transcendence. Esoteric & Somatic Practices Virgo's esoteric phrase: “I am the Mother and the Child. I, God, I, Matter, am.” Somatic focus on digestion: food, emotions, and experiences of eclipse season. Guided prompts: mindful eating, journaling, asking for support. Tarot & Practical Encouragement Tarot pulls (Page of Swords, Ace of Wands, 6 of Pentacles) → curiosity, new ideas, reciprocity. Believe in your value, trust opportunities, and align finances/relationships with reciprocity. NEW OFFERING 6-month Astrology Journey, Monday nights, starting in October! ______________________________________________ Cosmic Cousins Links Cosmic Cousins Memberships Cosmic Cousins Substack Cosmic Cousins Instagram Intro & Outro Music by:  Felix III Mentorship w/ Jeff Hinshaw Deep Dive Astrology Reading Tarot Soul Journey  Conversation with Dra. Rocío Rosales Meza Introduction: Mexicana Seer, medicine woman (Q'ero Inca lineage), PhD in Counseling Psychology. Key themes of conversation: Virgo archetype as Mother and service as devotion. Q'ero lineage and ancestral reciprocity. Her astrology: Virgo Sun, Aquarius Moon, Aries Rising. Pluto in Aquarius + collective shadow work. Survivors' guilt, systemic injustice, decolonial psychology. Personal story of health collapse during academia → grief, anger, alchemy, reclamation. Importance of prayer, presence, and relationship to Mother Earth. Closing prayer offered: “Great mother show me. Great mother speak with me. Great mother show up with me.” Closing Blessing & Reflection Reminder: you are both the nurturer and the one in need of nourishment. Reflection question: How might you create a container strong enough to hold the depth of your spiritual transformation? ____________________________________________________ NEW OFFERING 6-month Astrology Journey, Monday nights, starting in October! ______________________________________________ Cosmic Cousins Links Cosmic Cousins Memberships Cosmic Cousins Substack Cosmic Cousins Instagram Intro & Outro Music by:  Felix III Mentorship w/ Jeff Hinshaw Deep Dive Astrology Reading Tarot Soul Journey 

In this episode of Beyond the Paradigm, we dive into the money, influence, and politics behind Charlie Kirk and Turning Point USA. From Jewish and Christian Zionist donors to a staggering $150 million offer reportedly extended by Netanyahu himself — which Kirk allegedly turned down — we trace the forces shaping one of America's most influential political networks.We also examine Kirk's recent statements on Israel and their cultural, theological, and political implications.Links⁠⁠⁠⁠⁠⁠email:beyondtheparadigm@yahoo.com⁠⁠⁠⁠⁠⁠⁠Beyond the Paradigm - YouTube⁠⁠⁠⁠⁠⁠⁠instagram.com/paradigm1979⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠twitter.com/paradigm_79⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠(1) Facebook⁠⁠⁠⁠Support The Show⁠⁠⁠⁠⁠⁠patreon.com/BeyondTheParadigm⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠buymeacoffee.com/beyondthep5

Ran Baratz, military historian and former senior Israeli official, and author of What's Wrong with the Postmodern Military?, joins the show to discuss operations in Gaza and problems with how the IDF officer corps thinks about war. ▪️ Times     •      01:37 Introduction     •      02:27 Gaza     •      06:23 Diplomatic obstacles             •      12:27 Worse than you think     •      15:28 Paradigm shift              •      30:23 Real wars              •      38:49 Art of the general            •      43:51 War as policy             •      50:00 Netanyahu Follow along on Instagram, X @schoolofwarpod, and YouTube @SchoolofWarPodcast Find a transcript of today's episode on our School of War Substack

Saced Sexuality - An Updated Paradigm with Justin Pierce - The Mike Mantell Podcast by Sacred

DemystifySci is the place where we bring people together in search of the theories that will change the world, and Paradigm Drift is your chance to have a hand in that future. Theorists, randomly chosen, get 60 seconds to present their revolutionary idea... and then we see if it's gonna stand the test of time or if it's back into the tank for a little while longer.Next one will be Friday 10/17, @7pm Pacific. Sign up now: https://demystifysci.com/paradigm-drift-show. PATREON https://www.patreon.com/c/demystifysci00:00 Go! 00:03:00 Memory in Biological Systems00:10:00 Evolutionary Biology's Limitations00:18:20 Exploring Environmental Factors in Biology00:22:08 Global Integration00:24:40 Inductive Reactance in Electrical Engineering00:30:02 Archetypal Forcing in Social Models00:41:09 Cultural Dynamics and Circumcision00:45:50 Discussion on Circumcision and Medical Necessity00:47:44 Creating Sustainable Plasma Systems00:56:55 New Gravitational Theory Proposal01:04:02 A New Religion Based on Scientific Understanding01:07:48 Emotions and Cognitive Reactions01:09:23 Creation of a Unique Religion01:12:20 Defining Good and Evil01:14:09 Future Conversations on Religion01:16:58 Animal Perception of Reality01:19:22 Dreams and Awareness01:25:03 Objective Properties and Subjectivity01:28:00 Discussion on Philosophical Idealism01:32:00 Exploration of "I Think, Therefore I Am"01:33:00 Scientific Inquiry into Solar Phenomena01:40:00 Mechanism Behind Gravity and Light Interaction01:47:00 Connection of Art, Science, and Learning01:49:48 Exploring Information Within Waves01:52:00 Quantum Connections and Frequencies01:59:59 Theoretical Physics and Introduction to Published Works02:02:00 The Anatomy of the Spirit Body and Magneto-Receptive Vision02:06:10 Validity of Auras and Evolutionary Perspectives02:11:30 Barriers to Mainstream Science and Exploration02:11:44 Personal Perspectives on Theories and Research02:15:11 Exploration of Auras and Alternative Perception02:19:15 Encouragement for Experimental Evidence#physicscommunity , #Cosmology, #plasmaphysics , #gravity , #electromagnetism , #quantummechanics , #Consciousness, #Philosophy, #OpenMic, #DIYScience, #NewIdeas, #thinkforyourself #philosophypodcast , #sciencepodcast, #longformpodcast ABOUS US: Anastasia completed her PhD studying bioelectricity at Columbia University. When not talking to brilliant people or making movies, she spends her time painting, reading, and guiding backcountry excursions. Shilo also did his PhD at Columbia studying the elastic properties of molecular water. When he's not in the film studio, he's exploring sound in music. They are both freelance professors at various universities. PATREON: get episodes early + join our weekly Patron Chat https://bit.ly/3lcAasBMERCH: Rock some DemystifySci gear : https://demystifysci.myspreadshop.com/allAMAZON: Do your shopping through this link: https://amzn.to/3YyoT98DONATE: https://bit.ly/3wkPqaDSUBSTACK: https://substack.com/@UCqV4_7i9h1_V7hY48eZZSLw@demystifysciBLOG: http://DemystifySci.com/blog RSS: https://anchor.fm/s/2be66934/podcast/rssMAILING LIST: https://bit.ly/3v3kz2S SOCIAL: - Discord: https://discord.gg/MJzKT8CQub- Facebook: https://www.facebook.com/groups/DemystifySci- Instagram: https://www.instagram.com/DemystifySci/- Twitter: https://twitter.com/DemystifySciMUSIC: -Shilo Delay: https://g.co/kgs/oty671

Pastor Chad continued our Romans series by talking about the wrath of God. In times like these, it's not always easy or comfortable to think about God's wrath. But Pastor Chad reminded us that despite those feelings, we actually need God's wrath. If grace is God's love, His wrath is a reflection of His perfect justice.

Welcome back to Not Fintech Investment Advice, where Simon Taylor and I riff about fintech companies we're absolutely not giving investment advice on. (Speaking of Simon, he's got a new day job: he's joining Tempo, a payments-first blockchain incubated by Stripe and Paradigm. Will this lead to spicier payment takes? We shall see!) We kick things off with Welcome Tech, an operating system for immigrants. It's US-based, all-in-one: education, job placement, embedded healthcare (telemed, dental, vision, Rx), plus financial services (wallet, debit). After big 2020–21 rounds, a recent $7.5M caught Alex's eye. As for the real wedge? It may be “Help me not only survive but thrive” (that is, paperwork precision, employer integrations, and AI agents as the lawyer you can't afford. In this category, trust and timing decide outcomes… Next up is Bumper, a UK startup bringing BNPL to car repairs. With 5,000 dealerships already on board, they let customers split repair costs interest-free. Niche BNPL providers like this can thrive by embedding in industries big players overlook, giving businesses a way to keep their customer relationships while solving a very real pain point (not to mention, BNPL has rewired Gen Y and Z's expectations). Then there's Scalar Field (which Simon wrote about recently); an AI-powered trading tool that helps traders run strategies on live data and breaking new. By “living in the stream,” its models continuously adapt as it gives traders the ability to backtest in real time (instead of the traditional loop of training, validating, and hoping a model still works once deployed). The real unlock is backtesting against messy, real-world conditions, long an Achilles' heel in model development…that is, until now or soon?! Finally, Structify tackles the messy prep work before decisions get made. Think PDFs, screenshots, and scattered APIs, all cleaned and structured by an AI data assistant. If the last few decades were about faster decision making, the next decade is about fixing the data pipelines that feed… aforementioned decision making. Plus, some closing manifestations: banks and fintechs need to start treating gambling and speculative investing apps as a genuine competitive threat to deposits! U.S. banks should copy the UK's strategy of opt-in gambling blocks with cool-off periods to protect customers (and keep deposits from drifting). We'll be fans of whoever ships it first. Sign up for Alex's Fintech Takes newsletter for the latest insightful analysis on fintech trends, along with a heaping pile of pop culture references and copious footnotes. Every Monday and Thursday: https://workweek.com/brand/fintech-takes/ And for more exclusive insider content, don't forget to check out my YouTube page. Follow Simon: LinkedIn: https://www.linkedin.com/in/sytaylor/ Substack: https://sytaylor.substack.com   Follow Alex:  YouTube: https://www.youtube.com/channel/UCJgfH47QEwbQmkQlz1V9rQA/videos LinkedIn: https://www.linkedin.com/in/alexhjohnson Twitter: https://www.twitter.com/AlexH_Johnson Companies featured: https://www.welcome.tech/ https://www.bumper.co/ https://www.scalarfield.io/ https://www.structify.ai/

As Leslie Witt took to the stage Sept. 3 to deliver the keynote at Kaleidoscope, 8am's inaugural customer conference, it was the culmination of a whirlwind summer. It had been just four months since she had joined the company formerly known as AffiniPay as chief product officer, responsible for leading product transformation and strategy for established legal tech brands LawPay, MyCase, CASEpeer and Docketwise. In the intervening 16 weeks, the company had undergone a major rebrand and finalized details of its first major conference. Now, two weeks after the rebrand and as the conference got underway, Witt stood before the keynote audience detailing the company's newest product initiatives, including its upcoming launch of its generative AI-driven 8AM IQ.  Not long after Witt wrapped up her keynote, LawNext host Bob Ambrogi sat down with her live for this extended conversation. They spoke at the Kaleidoscope venue in Austin in a recording studio provided by 8am, where they discussed her background and career, her reasons for joining 8am, and the product announcements she had made earlier that day. Those announcements included the beta launch of an AI “Chat with Cases” feature that allows lawyers to ask questions of and search their case files, the integration of three core 8am products — LawPay, MyCase and SmartSpend — on a single technology platform, and more.  Before joining 8am in May, Witt had more than two decades of experience in leading product teams. Most recently, she had served as the chief product and design officer at the mental health and wellness technology company Headspace. She previously held senior positions at Intuit, where she led global design, research and innovation initiatives focused on small businesses.  Thank You To Our Sponsors This episode of LawNext is generously made possible by our sponsors. We appreciate their support and hope you will check them out. Paradigm, home to the practice management platforms PracticePanther, Bill4Time, MerusCase and LollyLaw; the e-payments platform Headnote; and the legal accounting software TrustBooks. Briefpoint, eliminating routine discovery response and request drafting tasks so you can focus on drafting what matters (or just make it home for dinner). Paxton, Rapidly conduct research, accelerate drafting, and analyze documents with Paxton. What do you need to get done today?    If you enjoy listening to LawNext, please leave us a review wherever you listen to podcasts.   Chapters 00:00 Introduction to 8AM and Leslie Witt 01:43 Leslie Witt's Background and Experience 09:53 Brand Transformation from Affinipay to 8AM 15:44 Product Design Philosophy and Customer Engagement 20:22 Platform Integration and New Features 24:57 Future Directions and Industry Impact

In this week's episode, Noah Drury recaps a wild Week 3 around the conference and welcomes Connor Happer of 1620 The Zone in Omaha. The two dive deep into Nebraska's early-season progress behind quarterback Dylan Raiola, including his command of the offense and the defense's surprising strength. They also cover UCLA's struggles after the firing of DeShaun Foster, USC's delayed win over Purdue, and Cal's upset of Minnesota. Looking forward, the conversation shifts to Nebraska's huge Week 4 test against Michigan and how the Cornhuskers can make a statement in Big Ten play.This episode is sponsored in part by TicketSmarter:Use promo code LWOS10 to receive $10 off purchases of $100 or moreUse promo code LWOS20 to receive $20 off purchases of $300 or moreThink smarter.  TicketSmarter

Jason W. Moore discusses the problematic history of the nature-society divide, his alternative world-ecology approach and the challenges of building socialism.   Shownotes Jason's personal website: https://jasonwmoore.com/ Jason at Binghamtom University: https://www.binghamton.edu/sociology/faculty/profile.html?id=jwmoore The World-Ecology Research Collective: https://worldecologynetwork.wordpress.com/ https://www.researchgate.net/lab/World-Ecology-Research-Collective-Jason-W-Moore Moore, J. W., & Patel, R. (2020).  A History of the World in Seven Cheap Things. A Guide to Capitalism, Nature, and the Future of the Planet. Verso. https://www.versobooks.com/products/817-a-history-of-the-world-in-seven-cheap-things Moore, J. W. (2015). Capitalism in the Web of Life. Ecology and the Accumulation of Capital. Verso. https://www.versobooks.com/products/74-capitalism-in-the-web-of-life for an overview of different approaches to conceptualizing society/capitalism and nature: https://www.historicalmaterialism.org/ecology-marxism-andreas-malm/ on Andreas Malm: https://en.wikipedia.org/wiki/Andreas_Malm Malm, A. (2018). The Progress of this Storm. Nature and Society in a Warming World. Verso. https://www.versobooks.com/products/574-the-progress-of-this-storm Malm, A. (2016). Fossil Capital. The Rise of Steam Power and the Roots of Global Warming. Verso. https://www.versobooks.com/products/135-fossil-capital Federici, S. (2004). Caliban and the Witch. Autonomedia. https://files.libcom.org/files/Caliban%20and%20the%20Witch.pdf on Ernst Haeckel: https://en.wikipedia.org/wiki/Ernst_Haeckel see also the chapter on Haeckel and the German Monist League in: Gasman, D. (2017). The scientific Origins of National Socialism. Routledge. https://www.taylorfrancis.com/books/mono/10.4324/9781315134789/scientific-origins-national-socialism-daniel-gasman on Actor-Network Theory: https://en.wikipedia.org/wiki/Actor%E2%80%93network_theory on Bruno Latour: https://en.wikipedia.org/wiki/Bruno_Latour on John Bellamy Foster: https://en.wikipedia.org/wiki/John_Bellamy_Foster Bellamy, J. F. (2000) Marx's Ecology. Materialism and Nature. Monthly Review Press. https://ia904504.us.archive.org/9/items/526394/John%20Bellamy%20Foster.%20Marx%27s%20Ecology..pdf on Kohei Saito: https://en.wikipedia.org/wiki/Kohei_Saito on Pietro Verri: https://en.wikipedia.org/wiki/Pietro_Verri Marx, K. (1976). Capital. A Critique of Political Economy. Volume One. Penguin. https://www.surplusvalue.org.au/Marxism/Capital%20-%20Vol.%201%20Penguin.pdf Marx's Theses on Feuerbach: https://www.marxists.org/archive/marx/works/1845/theses/theses.htm Marx's Economic and Philosophic Manuscripts of 1844: https://www.marxists.org/archive/marx/works/1844/manuscripts/preface.htm Marx's and Engel's German Ideology: https://www.marxists.org/archive/marx/works/1845/german-ideology/ Marx's Capital Vol. 3.: https://www.marxists.org/archive/marx/works/1894-c3/ Marx's On The Jewish Question: https://www.marxists.org/archive/marx/works/1844/jewish-question/ on Alfred Sohn-Rethel: https://en.wikipedia.org/wiki/Alfred_Sohn-Rethel Machado, C. & Miguel, N. (2013). The Money of the Mind and the God of Commodities. The real abstraction according to Sohn-Rethel. https://mpra.ub.uni-muenchen.de/48961/1/MPRA_paper_48961.pdf on Donna Haraway: https://en.wikipedia.org/wiki/Donna_Haraway on the “Special Period” in Cuba: https://en.wikipedia.org/wiki/Special_Period on James Lovelock: https://en.wikipedia.org/wiki/James_Lovelock Lovelock, J. (1979). Gaia. A New Look at Life on Earth. Oxford University Press. https://global.oup.com/academic/product/gaia-9780198784883?cc=de&lang=en&# on “Social metabolism”: https://en.wikipedia.org/wiki/Social_metabolism on Raymond Williams: https://en.wikipedia.org/wiki/Raymond_Williams Smele, J. D. (2016). The ‘Russian' Civil Wars, 1916-1926. Ten Years that Shook the World. Hurst. https://www.hurstpublishers.com/book/the-russian-civil-wars-1916-1926/ Engel-Di Mauro, S. (2021). Socialist States and the Environment. Lessons for Eco-Socialist Futures. Pluto Press. https://www.plutobooks.com/9780745340418/socialist-states-and-the-environment/ Amin, S. (1990). Delinking. Towards a Polycentric World. Zed Books. https://www.bloomsbury.com/uk/delinking-9780862328030/ on material and energy flow accounting: see the chapter on that topic in: Bartelmus, P. (2008). Quantitative Eco-nomics. How sustainable are our economies. Springer. https://link.springer.com/book/10.1007/978-1-4020-6966-6 Zeug, W. (2025). INDEP talk with Walther Zeug: Democratic Economic Planning through Cybernetics & Holistic Accounting. https://youtu.be/I4_8_lDfwEw?si=J-kdRzjIehZqPgs0 Kula, W. (2016). Measures and Men. Princeton University Press. https://press.princeton.edu/books/hardcover/9780691639079/measures-and-men Echterhölter, A. M. (2019). Quantification as Conflict. Witold Kula's Political Metrology and Its Reception in the West . Historyka : studia metodologiczne, 49, 117-141 . Article 9. https://journals.pan.pl/Content/114031/PDF/7%20ECHTERH%C3%96LTER.pdf on Max Weber: https://en.wikipedia.org/wiki/Max_Weber on Double-entry bookkeeping: https://en.wikipedia.org/wiki/Double-entry_bookkeeping on “proletarian science”: Moore, J.W. (2025). Nature and other dangerous words: Marx, method and the proletarian standpoint in the web of life. Dialectical Anthropology. 49, 149–167. https://link.springer.com/article/10.1007/s10624-025-09775-x on Ecosystem services: https://en.wikipedia.org/wiki/Ecosystem_service on the “Ecological footprint” concept: https://en.wikipedia.org/wiki/Ecological_footprint on Thomas Müntzer: https://en.wikipedia.org/wiki/Thomas_M%C3%BCntzer on the Royal Botanic Gardens/Kew Gardens: https://de.wikipedia.org/wiki/Royal_Botanic_Gardens_(Kew) on the Stakhanovite movement: https://en.wikipedia.org/wiki/Stakhanovite_movement on Cybernetics: https://en.wikipedia.org/wiki/Cybernetics on Earth systems science: https://en.wikipedia.org/wiki/Earth_system_science Selcer, P. (2018). The Postwar Origins of the Global Environment. How the United Nations Built Spaceship Earth. Columbia University Press. https://cup.columbia.edu/book/the-postwar-origins-of-the-global-environment/9780231166485/ Medina, E. (2014). Cybernetic Revolutionaries. Technology and Politics in Allende's Chile. MIT Press. https://uberty.org/wp-content/uploads/2015/10/Eden_Medina_Cybernetic_Revolutionaries.pdf on Cybernetics in the Soviet Union: https://en.wikipedia.org/wiki/Cybernetics_in_the_Soviet_Union on the Transitional demand: https://en.wikipedia.org/wiki/Transitional_demand see also: Trotsky's The Transitional Program: https://www.marxists.org/archive/trotsky/1938/tp/ on the Green New Deal: https://en.wikipedia.org/wiki/Green_New_Deal on the European Green Deal: https://en.wikipedia.org/wiki/European_Green_Deal on Geoengineering: https://en.wikipedia.org/wiki/Geoengineering on Johan Rockström: https://en.wikipedia.org/wiki/Johan_Rockstr%C3%B6m on Planetary boundaries: https://www.stockholmresilience.org/research/planetary-boundaries.html Klein, N. (2015). This Changes Everything. Capitalism vs. the Climate. Penguin. https://thischangeseverything.org/book/ Kushi, S., & Toft, M. D. (2022). Introducing the Military Intervention Project: A New Dataset on US Military Interventions, 1776–2019. Journal of Conflict Resolution, 67(4), 752-779. https://journals.sagepub.com/doi/10.1177/00220027221117546 on Allen Dulles: https://en.wikipedia.org/wiki/Allen_Dulles on Reinhard Gehlen: https://en.wikipedia.org/wiki/Reinhard_Gehlen Talbot, D. (2016). The Devil's Chessboard. Allen Dulles, the CIA, and the Rise of America's Secret Government. Harper Collins. https://www.harpercollins.com/products/the-devils-chessboard-david-talbot?variant=32207669559330 on the concept of the Deep State: Scott, P. D. (1996). Deep Politics and the Death of JFK. University of California Press. https://www.ucpress.edu/books/deep-politics-and-the-death-of-jfk/paper Scott, P. D. (2017). The American Deep State. Big Money, Big Oil, and the Struggle for U.S. Democracy. Rowman & Littlefield. https://archive.org/details/americandeepstat0000scot/page/n5/mode/2up Good, A. (2022). American Exception. Empire and the Deep State. Skyhorse Publishing. https://www.skyhorsepublishing.com/9781510769144/american-exception/ on the origin of the concept: https://en.wikipedia.org/wiki/Deep_state_in_Turkey https://en.wikipedia.org/wiki/Susurluk_car_crash recently released files relating to the assassination of JFK on the website of the National Archives and Records Administration (NARA): https://www.archives.gov/research/jfk/release-2025 on the current state of knowledge on the Nord Stream Pipeline Explosion: https://www.reuters.com/world/europe/what-is-known-about-nord-stream-gas-pipeline-explosions-2025-08-21/ on the Nord Stream Pipeline Explosion releasing massive Amounts of Methane: https://youtu.be/7KBsf7bX9Nc?si=tDIxlFFF2ThO6Aeb on Systems Dynamics: https://en.wikipedia.org/wiki/System_dynamics the ‘Limits to Growth' Report, commissioned by the Club of Rome: https://www.clubofrome.org/publication/the-limits-to-growth/ the Club of Rome: https://www.clubofrome.org/ on Jay Wright Forrester: https://en.wikipedia.org/wiki/Jay_Wright_Forrester on the concept of the Anthropocene: https://en.wikipedia.org/wiki/Anthropocene on James C. Scott: https://en.wikipedia.org/wiki/James_C._Scott Mies, M. & Bennholdt-Thomsen, V. (1999). The Subsistence Perspective. Beyond the Globalised Economy. Zed Books. https://www.bloomsbury.com/us/subsistence-perspective-9781856497763/ on the New Economic Policy (NEP): https://en.wikipedia.org/wiki/New_Economic_Policy on the Belt and Road Initiative: https://en.wikipedia.org/wiki/Belt_and_Road_Initiative Nachmani, A. (1990). Civil War and Foreign Intervention in Greece: 1946-49. Journal of Contemporary History, 25(4), 489–522. https://www.jstor.org/stable/260759 on the “Soft Coup against the Wilson Labour Government”: https://www.declassifieduk.org/a-possible-coup-against-the-labour-government/ https://www.mi5.gov.uk/history/the-cold-war/the-wilson-plot https://www.theguardian.com/commentisfree/2006/mar/15/comment.labour1 on the actions of the US against North Korea in the Korean War: https://en.wikipedia.org/wiki/War_crimes_in_the_Korean_War https://en.wikipedia.org/wiki/Bombing_of_North_Korea https://en.wikipedia.org/wiki/Allegations_of_biological_warfare_in_the_Korean_War on the Cultural Revolution: https://en.wikipedia.org/wiki/Cultural_Revolution on Mao's concept of the Mass Line: https://www.marxists.org/reference/archive/mao/works/red-book/ch11.htm on Jung's concept of the Collective unconscious: https://en.wikipedia.org/wiki/Collective_unconscious on (Neo-)Malthusianism: https://en.wikipedia.org/wiki/Malthusianism Ehrlich, P. R. (1971). The Population Bomb. Ballantine Books. http://pinguet.free.fr/ehrlich68.pdf Tainter, J. A. (1988). The Collapse of Complex Societies. Cambridge University Press. https://www.sustainable.soltechdesigns.com/Joseph-A-Tainter-The-collapse-of-complex-societies.pdf on Millenarianism: https://en.wikipedia.org/wiki/Millenarianism Enzensberger, H. M. (1978). Two Notes on the End of the World. New Left Review. I/110. https://newleftreview.org/issues/i110/articles/hans-magnus-enzensberger-two-notes-on-the-end-of-the-world Hansen, J. (2010). Storms of my Grandchildren. The Truth about the Coming Climate Catastrophe and Our Last Chance to Save Humanity. Bloomsbury. https://www.bloomsbury.com/in/storms-of-my-grandchildren-9781408807460/ Sweezy, P.M. (1990). Monopoly Capitalism. In: Eatwell, J., Milgate, M., Newman, P. (eds) Marxian Economics. Palgrave Macmillan. https://link.springer.com/chapter/10.1007/978-1-349-20572-1_44 on Technofeudalism: Varoufakis, Y. (2024). Technofeudalism. What Killed Capitalism. Penguin. https://www.penguin.co.uk/books/451795/technofeudalism-by-varoufakis-yanis/9781529926095 Durand, C. (2024). How Silicon Valley Unleashed Techno-feudalism. The Making of the Digital Economy. Verso. https://www.versobooks.com/products/2790-how-silicon-valley-unleashed-techno-feudalism Culture, Power and Politics Podcast episode on the debate around the concept “Technofeudalism”: https://culturepowerpolitics.org/2025/07/04/is-capitalism-over-the-technofeudalism-debate/ Conservation International: https://www.conservation.org/ Earth League International: https://earthleagueinternational.org/ Rockström, J. et al. (2024). The Planetary Commons. A new Paradigm for Safeguarding Earth-regulating Systems in the Anthropocene. Proceedings of the National Academy of Sciences of the United States of America. https://www.pnas.org/doi/10.1073/pnas.2301531121 the Trilateral Commission: https://www.trilateral.org/ the Earth Commission: https://earthcommission.org/ Johan Rockström's interview in the Guardian: https://www.theguardian.com/environment/2021/may/29/johan-rockstrom-interview-breaking-boundaries-attenborough-biden   Future Histories Episodes on Related Topics S3E44 | Anna Kornbluh on Climate Counteraesthetics https://www.futurehistories.today/episoden-blog/s03/e44-anna-kornbluh-on-climate-counteraesthetics/ S03E33 | Tadzio Müller zu solidarischem Preppen im Kollaps https://www.futurehistories.today/episoden-blog/s03/e33-tadzio-mueller-zu-solidarischem-preppen-im-kollaps/ S03E30 | Matt Huber & Kohei Saito on Growth, Progress and Left Imaginaries https://www.futurehistories.today/episoden-blog/s03/e30-matt-huber-kohei-saito-on-growth-progress-and-left-imaginaries/ S03E23 | Andreas Malm on Overshooting into Climate Breakdown https://www.futurehistories.today/episoden-blog/s03/e23-andreas-malm-on-overshooting-into-climate-breakdown/ S03E19 | Wendy Brown on Socialist Governmentality https://www.futurehistories.today/episoden-blog/s03/e19-wendy-brown-on-socialist-governmentality/   --- If you are interested in democratic economic planning, these resources might be of help: Democratic planning – an information website https://www.democratic-planning.com/ Sorg, C. & Groos, J. (eds.)(2025). Rethinking Economic Planning. Competition & Change Special Issue Volume 29 Issue 1. https://journals.sagepub.com/toc/ccha/29/1 Groos, J. & Sorg, C. (2025). Creative Construction - Democratic Planning in the 21st Century and Beyond. Bristol University Press. [for a review copy, please contact: amber.lanfranchi[at]bristol.ac.uk] https://bristoluniversitypress.co.uk/creative-construction International Network for Democratic Economic Planning https://www.indep.network/ Democratic Planning Research Platform: https://www.planningresearch.net/ --- Future Histories Contact & Support If you like Future Histories, please consider supporting us on Patreon: https://www.patreon.com/join/FutureHistories Contact: office@futurehistories.today Twitter: https://twitter.com/FutureHpodcast Instagram: https://www.instagram.com/futurehpodcast/ Mastodon: https://mstdn.social/@FutureHistories English webpage: https://futurehistories-international.com   Episode Keywords #JasonWMoore, #JanGroos, #Interview, #FutureHistories, #FutureHistoriesInternational, #futurehistoriesinternational, #DemocraticPlanning, #DemocraticEconomicPlanning, #PoliticalEconomy, #History, #Revolution, #Revolutions, #Ecology, #Environmental, #Colonialism, #Imperialism, #Capitalism, #Economics, #DeepState, #WorldEcology, #NatureSocietyDivide, #KarlMarx, #Socialism, #Cybernetics

What a night in Johnson County!

Sometimes the best move in business is pulling the plug on something that's “working” (ugh lol)This episode is more personal than usual because I'm opening up about sunsetting our Set to Scale® membership. It's a decision that didn't come lightly, but one that brought me more clarity (and relief) than I expected in the chaos of it all.I'm sharing:Why a membership that looked profitable on paper wasn't sustainable in real lifeThe mix of trauma, vulnerability, and strategy that pushed me to finally make the callWhat this shift means for how Paradigm is serving clients moving forward How you can think about your own offers when it's time to pivot or let goIf you've ever had to retire an offer, or are staring down a decision you know you need to make, this one will definitely hit home.

This week join Izzah Wahab for a discussion of her research on estrogren, specifically E1, and how it uses he GPCR signaling paradigm in relation to cancer progression. For upcoming interviews check out the Grad Chat webpage on Queen's University School of Graduate Studies & Postdoctoral Affairs website – https://www.queensu.ca/grad-postdoc/research/share/grad-chat

Stripe has unveiled Tempo, a new blockchain built for high-throughput stablecoin payments, developed with Paradigm and backed by partners like Visa, Shopify, and Anthropic. The launch has set off a firestorm—Ethereum advocates bristle at yet another corporate L1, critics call it a VC chain, and skeptics question whether credible neutrality is even possible under Stripe's leadership. Is Tempo the next Visa for stablecoins, or just the ghost of Libra reborn? Today's Breakdown explores the clash between decentralization ideals and the pragmatic rise of enterprise blockchains. Enjoying this content? SUBSCRIBE to the Podcast: https://pod.link/1438693620 Watch on YouTube: https://www.youtube.com/@TheBreakdownBW Subscribe to the newsletter: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://blockworks.co/newsletter/thebreakdown⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Join the discussion: https://discord.gg/VrKRrfKCz8 Follow on Twitter: NLW: https://twitter.com/nlw Breakdown: https://twitter.com/BreakdownBW

In this episode we are joined by Austin Campbell where we cover how Wall Street is piling into Bitcoin and crypto as the Federal Reserve prepares rate cuts, Nasdaq's push to the SEC to trade tokenized stocks, Google's plan for a universal blockchain ledger, Stripe and Paradigm's launch of the Tempo payments blockchain, South Korea's UBIT rolling out an Ethereum Layer-2 —all while a Putin adviser claims the U.S. may secretly use crypto to reset its $37 trillion debt. Join us as we dive into how Bitcoin, crypto, and blockchain adoption are accelerating across Wall Street, tech giants, and global finance.

Noah Drury dives into the action-packed slate from Big Ten Week 2. Michigan State pulled out a dramatic double-overtime win over Boston College, while Michigan struggled to find answers against Oklahoma. Penn State's Drew Allar continues to be under the microscope as questions swirl around his consistency. Oregon dominated Oklahoma State, setting the stage for their highly anticipated matchup with Penn State later this month. Noah also highlights Illinois, Nebraska, Rutgers, and Iowa, breaking down key performances and lingering concerns.This episode is sponsored in part by TicketSmarter:Use promo code LWOS10 to receive $10 off purchases of $100 or moreUse promo code LWOS20 to receive $20 off purchases of $300 or moreThink smarter.  TicketSmarter

Abuse recovery, healing, and faith collide in this powerful episode with author Andi Bull. Discover lessons from her book When Your Protectors Didn't, and learn how to find hope, identity, and strength—even if you weren't abused. This memoir-style conversation will inspire women to embrace healing, overcome imposter syndrome, and see their stories through God's eyes.Andi's book transformed my perspective, showing me that healing is possible and biblical stories hold deeper meaning than I ever realized. Whether you've experienced trauma or simply battled perfectionism, people-pleasing, or anxiety, this episode will meet you where you are.Timestamps:(00:00) Introduction: Why this episode is for every woman(03:15) Meeting author Andy Bull and her powerful book When Your Protectors Didn't Protect(09:45) Overcoming perfectionism, people-pleasing, and performance anxiety(15:28) Biblical lessons that transform how we see ourselves and God's love(22:40) Andy's childhood abuse and the moment she realized her “normal” wasn't normal(31:10) How imposter syndrome shows up in writing, faith, and life(39:55) Discovering surrender through hardship, cancer, and God's presence(48:20) Paradigm shifts: seeing life differently and suspending judgment(55:45) The power of sharing your story to help others healKey Takeaways:You don't have to be abused to relate to abuse recovery—perfectionism and people-pleasing carry similar wounds.Biblical stories hold fresh, healing insights when we look at them with open hearts.Abuse and dysfunction are not normal, even if they've been your lived experience.Imposter syndrome can be overcome by embracing identity as a daughter of the King.Sharing your story is one of the most powerful ways to connect, heal, and empower others.Guest Bio:For over twenty-five years, Andi has dedicated herself to the study of God's word, graduating from the King's University with her Master's in 2003.As she read the Bible through the eyes of a survivor of traumatic childhood abuse, she saw how God passionately seeks the lost, gently restores the broken, and tenderly heals broken hearts. Andi became inspired to advocate for emotional well-being, not only for herself but also for the women she is privileged to mentor one-on-one and those she speaks to at conferences. The lessons and insights she gained are in her book, When Your Protectors Didn't: Healing from a Past of Broken Pieces. Raised in South Africa as a child, she now resides in sunny Southern California with her husband, daughter, and pups. She loves her family, friends, pups, and coffee—lots and lots of coffee! Resource Links:Get Andi Bull's book: When Your Protectors Didn't Protect https://a.co/d/5naO43ILearn more at lesakoski.comTags/Keywords:abuse recovery, healing after abuse, childhood trauma, Christian healing, women over 40 podcast, people pleasing, perfectionism, imposter syndrome, memoir podcast, faith and healing, God's love, When Your Protectors Didn't Protect, Andy Bull

In this episode of The Cash Rich Exit Podcast, host Colleen O'Connell-Campbell sits down with Ashley Hopkins, President & CEO of Paradigm Commercial Group, and Sarah Vandenbelt, Broker of Record & Founder of Paradigm Commercial Real Estate. Together, they share how their unexpected journeys into real estate led to a powerful partnership under the Paradigm brand.   We discuss: The winding career paths that brought them into real estate. Why building strategic partnerships and strong networks is critical in a male-dominated industry. How property management is more than collecting rent - it's finance, legal, emergency planning, and community-building rolled into one. The importance of due diligence and long-term planning in both investing and property ownership. Practical insights for business owners who want to use real estate strategically - whether as an operating base or an investment vehicle. How adaptability, collaboration, and leveraging trusted relationships drive success in real estate. Their stories highlight what's possible when business owners align passion with purpose, and when professionals join forces to provide full-service real estate solutions tailored to client needs.   Fun Frank Advice: Ashley: “Don't take no for an answer. An obstacle is just an opportunity in disguise. Keep pushing, keep looking for resources, and surround yourself with the right people.” Sarah: “Don't wait until you feel ready. Bet on yourself, take the leap, and trust that you'll figure it out.” Connect with Ashley & Sarah

Daniel Lewis has witnessed legal technology's evolution from multiple vantage points that few others can claim. As a Stanford law student in 2012, he and classmate Nik Reed co-founded the legal research startup Ravel Law with the audacious goal of taking on LexisNexis and Westlaw using machine learning and data analytics – at a time when such challengers were few and far between. Not only was Ravel Law pioneering in its own right, but it also spearheaded and funded the Caselaw Access Project, an ambitious partnership with Harvard Law School's Library Innovation Lab to digitize and provide free and open access to every official court decision ever published in the United States.  After Ravel's acquisition by LexisNexis in 2017, Lewis spent the next five years leading product teams within the legal research giant, including as vice president and general manager of its Practical Guidance and analytics products. This dual perspective – startup founder turned corporate executive – helped shape his understanding of what works and what doesn't when building technology for lawyers.  Today, as CEO and global chief executive of LegalOn Technologies, Lewis leads a 600-person company that is tackling contract review with a fundamentally different approach. Rather than relying solely on tech-enabled services or raw AI that can hallucinate legal advice, LegalOn combines large language models with attorney-developed playbooks to help in-house legal teams achieve up to 85% time savings on contract review. The company just raised $50 million, for a total raise of $200 million across multiple funding rounds – which Lewis says makes it the most well-funded AI company focused on in-house contract review  – and announced a strategic partnership with OpenAI to develop AI agents for legal workflows.  In this wide-ranging conversation, Lewis shares hard-won insights about the realities of legal tech entrepreneurship, from the "deranged" confidence required to challenge industry giants as a law student to the leadership lessons learned managing teams through multiple business transformations. He discusses why the current moment represents the most significant opportunity for legal tech innovation in decades, how AI agents will reshape routine legal work, and what he's learned about building technology that lawyers don't just try once but actually integrate into their daily practices.  Related episodes: From Ravel Cofounder to Knowable CEO, Nik Reed Has Learned that Building Quality AI for Legal Takes A Lot of Hard Work.  On LawNext: The Inside Story of the Caselaw Access Project, with Three of the People Who Made It Happen.   Thank You To Our Sponsors This episode of LawNext is generously made possible by our sponsors. We appreciate their support and hope you will check them out.   Paradigm, home to the practice management platforms PracticePanther, Bill4Time, MerusCase and LollyLaw; the e-payments platform Headnote; and the legal accounting software TrustBooks. Briefpoint, eliminating routine discovery response and request drafting tasks so you can focus on drafting what matters (or just make it home for dinner). Paxton, Rapidly conduct research, accelerate drafting, and analyze documents with Paxton. What do you need to get done today?    If you enjoy listening to LawNext, please leave us a review wherever you listen to podcasts.  

This episode is part two of our deep dive into liberating the artist within. We continue exploring powerful spiritual, mental, and physical shifts that help creators redefine success, embrace sensitivity as a superpower, and release limiting stories about abundance. Tune in to learn how to ground yourself energetically, trust your unique creative flow, and confidently claim your worth in a new paradigm where artists thrive, create with love, and build a more abundant, balanced reality.Join the iconic ooom membership here: https://www.ooomies.com/oasis[Live Stream Transmission is always on the first Friday of the month]

Dr. Sumanta (Monty) Pal and Dr. Petros Grivas discuss innovative new intravesical therapies and other recent advances in the treatment of non-muscle invasive bladder cancer. TRANSCRIPT Dr. Sumanta (Monty) Pal: Hello and welcome. I'm Dr. Monty Pal here at the ASCO Daily News Podcast. I'm a medical oncologist and professor and vice chair of academic affairs at the City of Hope Comprehensive Cancer Center in Los Angeles. And I'm really delighted to be your new host here. Today's episode is going to really sort of focus on an area near and dear to my heart, something I actually see in the clinics, and that's bladder cancer. We're specifically going to be discussing non-muscle invasive bladder cancer, which actually comprises about 75% of new cases. Now, in recent years, there's been a huge shift towards personalized bladder-preserving strategies, including innovative therapies and new agents that really are reducing reliance on more primitive techniques like radical cystectomy and radiation therapy. And I'm really excited about this new trend. And really at the forefront of this is one of my dear friends and colleagues, Dr. Petros Grivas. He's a professor in the Department of Medicine and Division of Hematology Oncology at the University of Washington. It's going to take a while to get through all these titles. He's taken on a bunch of new roles. He is medical director of the International Program, medical director of the Local and Regional Outreach Program, and also professor in the Clinical Research Division at the Fred Hutch Cancer Center. Petros, welcome to the program. Dr. Petros Grivas: Thank you so much, Monty. It's exciting for me to be here. Dr. Sumanta (Monty) Pal: Just FYI for our audience, our disclosures are available in the transcript of this episode.  We're going to get right into it, Petros. Non-muscle invasive bladder cancer, this is a really, really challenging space. We see a lot of recurrence and progression of the disease over time, about 50% to 70% of patients do have some recurrence after initial treatment, and about 30% are ultimately going to progress on to muscle-invasive or metastatic disease. Now, I will say that when you and I were in training, non-muscle invasive bladder cancer was something that was almost relegated to the domain of the urologist, right? They would use treatments such as BCG (Bacillus Calmette-Guérin) in a serial fashion. It was rare, I think, for you and I to really enter into this clinical space, but that's all changing, isn't it? I mean, can you maybe tell us about some of the new therapies, two or three that you're really excited about in this space? Dr. Petros Grivas: Monty, you're correct. Traditionally and conventionally, our dear friends and colleagues in urology have been managing patients with non-muscle invasive bladder cancer. The previous term was superficial bladder cancer. Now, it has changed, to your point, to non-muscle invasive bladder cancer. And this has to do with the staging of this entity. These tumors in superficial layers of bladder cancer, not invading the muscularis propria, the muscle layer, which makes the bladder contract for urine to be expelled. As you said, these patients have been treated traditionally with intravesical BCG, one of the oldest forms of immunotherapy that was developed back in the 1970s, and this is a big milestone of immunotherapy development. However, over the years, in the last 50 years, there were not many options for patients in whom the cancers had progression or recurrence, came back after this intravesical BCG. Many of those patients were undergoing, and many of them still may be undergoing, what we call radical cystectomy, meaning removal of the bladder and the lymph nodes around the bladder. The development of newer agents over the last several years has given the patients the option of having other intravesical therapies, intravesical meaning the delivery of drugs, medications inside the bladder, aiming to preserve the bladder, keep the bladder in place. And there are many examples of those agents. Just to give you some examples, intravesical chemotherapy, chemotherapy drugs that you and me may be giving intravenously, some of them can be given inside the bladder, intravesical installation. One example of that is a combination of gemcitabine and docetaxel. These drugs are given in sequence one after the other inside the bladder, and they have seen significant efficacy, good results, again, helping patients keeping the bladder when they can for patients with what we call BCG unresponsive non-muscle invasive bladder cancer. And again, there's criteria that the International Bladder Cancer Group and the FDA developed, how to define when BCG fails, when we have BCG unresponsive non-muscle invasive bladder cancer. Dr. Sumanta (Monty) Pal: And we're actually going to get into some of the FDA requirements and development pathways and so forth. What I'm really interested in hearing, and I'm sure our audience is too, are maybe some of the new intravesical treatments that are coming around. I do think it's exciting that the gemcitabine and docetaxel go into the bladder indeed, but what are some of the top new therapies? Pick two or three that you're excited about that people should be looking out for in this intravesical space. Dr. Petros Grivas: For sure, for sure. In terms of the new up-and-coming therapies, there are a couple that come to mind. One of them is called TAR-200, T-A-R 200. This agent is actually a very interesting system. It's an intravesical delivery of a chemotherapy called gemcitabine, the one that I just mentioned a few minutes ago, that is actually being delivered through what we call a pretzel, which is like a rounded [pretzel-shaped] structure working like an osmotic pump, and that is being delivered inside the bladder intravesically by urologists. And this drug is releasing, through the osmotic release mechanism, this chemotherapeutic drug, gemcitabine, inside the bladder. And this can be replaced once every 3 weeks in the beginning. And the data so far from early-phase trials are really, really promising, showing that this agent may be potentially regulatory approved down the road. So TAR-200 is something to keep in mind. And similarly, in the same context, there is a different drug that also uses the same mechanism, and this osmotic release, this pretzel, it's just encoded with a different agent. The different agent is an FGFR inhibitor, a target therapy called erdafitinib, a drug that you and me may give in patients with metastatic urothelial carcinoma if they have an FGFR3 mutation or fusion. And that drug is called TAR-210. Dr. Sumanta (Monty) Pal: And can I ask you, in that setting, do you have to have an FGFR3 mutation to receive it? Or what is the context there? Dr. Petros Grivas: So for TAR-210, TAR-2-1-0, usually there is a checking to see if there is an FGFR3 mutation or fusion. And the big question, Monty, is do we have adequate tissue, right? From a limited tissue on what we call the TURBT, right, that urologists do. And now there is a lot of development in technology, for example, urine circulating tumor DNA to try to detect these mutations in the urine to see whether the patient may be eligible for this TAR-210. Both of those agents are not FDA approved, but there are significant promising clinical trials. Dr. Sumanta (Monty) Pal: So now let's go to a rapid-fire round. Give us two more agents that you're excited about in this intravesical space. What do you think? Dr. Petros Grivas: There is another one called cretostimogene. It's a long name. Dr. Sumanta (Monty) Pal: They really make these names very easy for us, don't they? Dr. Petros Grivas: They are not Greek names, Monty, I can tell you, you know. Even my Greek language is having trouble pronouncing them. The cretostimogene, it's actually almost what we call a growth factor, a GM-CSF. The actual name of this agent is CG0070. This is a replicating mechanism where GM-CSF is replicating in cells. And this agent has shown significant results again, like the TAR-200, in BCG unresponsive non-muscle invasive bladder cancer. I would say very quickly, two agents that actually were recently approved and they're already available in clinical practice, is nadofaragene firadenovec, another long name. That's a non-replicating vector that has the gene of interferon alfa-2b that stimulates the immune system in the bladder. It's given once every 3 months. And the last one that was, as I mentioned, already FDA approved, it's an interleukin-15 superagonist. It's another long name, which is hard to pronounce, but I will give it a try. It's a drug that was recently actually approved also in the UK. The previous name was N-803. It's given together with BCG as a combination for BCG unresponsive non-muscle invasive bladder cancer. Dr. Sumanta (Monty) Pal: This is a huge dilemma, I think, right? Because if you're a practicing, I'm going to say urologist for the moment, I guess the challenge is how do you decide between an IL-15 superagonist? How do you decide between a pretzel-eluting agent? How do you decide between that and maybe something that's ostensibly, I'm going to guess, cheaper, like gemcitabine and docetaxel? What's sort of the current thinking amongst urologists? Dr. Petros Grivas: Multiple factors play into our account when the decision is being made. I discuss with urologists all the time. It's not an easy decision because we do not have head-to-head comparisons between those agents. As you mentioned, intravesical chemotherapy with gemcitabine and docetaxel has been used over the years and this is the lowest cost, I would say, the cheapest option with good efficacy results. Obviously, the nadofaragene firadenovec every 3 months and the interleukin-15 superagonist, N-803, plus BCG have also been approved. The question is availability of those agents, are they available? Are they reimbursed? Cost of those agents can come into play. Frequency of administration, you know, once every 3 months versus more frequent. And of course, the individual efficacy and toxicity data, preference of the patients; sometimes the provider, the urologist, may have something that they may be more familiar with. But we lack this head-to-head comparison. Of course, I want to make sure I mention that radical cystectomy may still be the option for appropriate patients. So that complicates also the decision making and has to be individualized, customized, and personalized, taking into account all those factors. And there is not one size fitting all. Dr. Sumanta (Monty) Pal: So I think we discussed five intravesical therapies. As you point out, and you know, I'm going to get some calls about this: I think I referred to radical cystectomy as being a more primitive procedure. Not true at all. I think it's something that still is, you know, a mainstay of management in this disease space. But I guess it gets even more complicated, am I right, Petros? Because now we have systemic therapies that we can actually apply in this non-muscle invasive setting for at this point, refractory disease. Can you maybe just give us a quick two-minute primer on that? Dr. Petros Grivas: Absolutely, and systemic therapies now come into play, as you said. And a classical example of that, Monty, came from the KEYNOTE-057 trial that we published about 6 years ago. This is intravenous pembrolizumab, given intravascularly, intravenously, as opposed to the previously discussed intravesical administration of agents. Pembrolizumab was tested in that KEYNOTE-057 trial and showed efficacy about, I would say, one out of five patients, about 20%, had a complete response of the tumor in the bladder in a year after starting the treatment. Again, it's hard to compare across different agents, but obviously when we give something intravenously, there is a risk of toxicity, side effects systemically, what we call immune-related adverse events. And this can also play in the decision making, right? When you have intravesical agents versus intravascular agents, there is different toxicity profiles in terms of systemic toxicity. But intravenous pembrolizumab has been an option, FDA approved, since, if I remember, it was early 2020 when this became FDA approved. There are other agents being tested in this disease, but like atezolizumab through the SWOG study that Dr. Black and Dr. Singh led, but atezolizumab is not FDA approved for this indication. Again, this is for BCG unresponsive, high-risk, non-muscle invasive bladder cancer. Dr. Sumanta (Monty) Pal: So maybe teach us how it works, for instance, at an expert center like the Fred Hutch. When you see a patient with non-muscle invasive bladder cancer, there's obviously the option of surgery, there's the intravesical therapies, which I imagine the urology team is still really at the helm of. But then, I guess there has to be consideration of all options. So you've got to bring up systemic therapy with agents like pembrolizumab. In that context, are you involved that early on in the conversation? Dr. Petros Grivas: That's a great discussion, Monty. Paradigm is shifting as we mentioned together. The urologists have been treating these patients and still they are the mainstay of the treaters, the managers in this disease. But medical oncologists come to play more and more, especially with the FDA approval of intravenous pembrolizumab about 5 years ago [GC1]  [KM2] . We have the concept of multidisciplinary bladder cancer clinic here at Fred Hutch and University of Washington. This happens every Tuesday morning, and we're very excited because it's a one-stop shop for the patients. We have the urologist, a medical oncologist, radiation oncologist, and experts from radiology and pathology, and we all review cases specifically with muscle-invasive bladder cancer. But every now and then, we see patients with BCG unresponsive non-muscle invasive bladder cancer. And this is where we discuss and we talk to the patient about pros and cons of all those options. And that's a classic example where medical oncologists may start to see those patients and offer their input and expertise. In addition to that, sometimes we have clinical trials, we may see these patients because there are systemic agents that may be administered in this setting. We have the SunRISe trial program that includes also a systemically administered checkpoint inhibitor. So that's another example where we see patients either in the context of multi-clinic or in individual solo clinics to counsel the patients about the pros and cons of the systemically administered agents in the context of clinical trials. Usually checkpoint inhibitors are the class of agents that are being tested in this particular scenario. Dr. Sumanta (Monty) Pal: I can see a scenario where it's really going to require this sort of deep dive, much in the way that we do for prostate cancer, for instance, where the medical oncologist is involved very early on and planning out any sort of systemic therapy component of treatment or at the very least, at least spelling out those options. I think it's going to be really interesting to see what this space looks like 5 or 10 years down the road. In closing, I wanted to go through something that I think is so different in this space, at least for the time being, and that is the paradigm for FDA approval. When you and I have our fellows in the clinics, we always say, “Look, you know, the paradigm in this disease and that disease and the other disease needs to be phase 3 randomized trials, right? Big thousand patient experiences where you're testing clinical endpoints.” That's tough in non-muscle invasive bladder cancer, right? Because thankfully, outcomes can actually be quite good, you know, in this setting, right? It's tough to actually estimate overall survival in some of these early-stage populations. Tell me what the current regulatory bar is, and this is a tough thing to do in 2 minutes or less but tell me where you see it headed. Dr. Petros Grivas: You alluded to that before, Monty, when I was giving the background and we talked about the regulatory approval. And I have to very quickly go back in time about 10 years ago because it's important for context that can help us in other disease types too. We had workshops with the FDA and the NCI with the help of the International Bladder Cancer Group and other colleagues. And we try to define a framework, what endpoints are meaningful for those patients in this disease. It was a multidisciplinary, multiple stakeholders meeting, where we tried to define what is important for patients. What are the available agents? What are the trial designs we can accept? And what are the meaningful endpoints that the regulatory agencies can accept for regulatory approval? And that was critical in that mission because it allowed us to design clinical trials, for example, single-arm trials in a disease where there was no standard of care. There was intravesical valrubicin and chemotherapy anthracycline that was approved for many years, but was not practically used in clinical practice, despite being approved, the valrubicin. And because of that, the FDA allowed these single-arm trials to happen. And obviously the endpoint was also discussed in that meeting. For example, for carcinoma in situ, complete response, clinical complete response, because the bladder remains intact in many patients, clinical complete response was a meaningful primary endpoint, also duration of response is also very important. So what is the durable clinical complete response in 1 year or 18 months is relevant. And when you have papillary tumors like Ta or T1 with CIS, for papillary tumors, event-free survival becomes one of the key endpoints and you look at it over time, for example, at 12 or 18 months, what is the event-free survival? So clinical complete response, duration of response, event-free survival, depending on the CIS presence or papillary tumors, I think these are endpoints that have allowed us to design those trials, get those agents approved.  Now, the question going forward, Monty, and we can close with that is, since now we have the embarrassment of riches, many more options available compared to where we were 6 and 7 years ago, is now the time to do randomized trials? And if we do randomized trials, which can be the control group? Which of those agents should be allowed to be part of the control group? These are ongoing discussions right now with the NCI, with other agencies, cooperative groups, trying to design those trials and move forward from here.[GC3]  Dr. Sumanta (Monty) Pal: Well, it's awesome to have you here on the program so we can get some early looks into some of these conversations. I mean, clearly, you're at the table at a lot of these discussions, Petros. So I want to thank you for sharing your insights with us today. This was just tremendous. Dr. Petros Grivas: Thank you, Monty. You know, patients in the center, I just came back from the Bladder Cancer Advocacy Network meeting in Washington, D.C., and we discussed all those questions, the topics you very eloquently mentioned and asked me today, and patients gave us great feedback and patients guide us in that effort. Thank you so, so much for having me and congratulations for the amazing podcast you're doing. Dr. Sumanta (Monty) Pal: Oh, cheers, Petros, thanks so much.  And thank you to the listeners who joined us today. If you really like the insights that you heard on this ASCO Daily News Podcast, please rate, review, and subscribe wherever you get your podcasts. Thanks, everyone. Disclaimer: The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement.   Find out more about today's speakers:      Dr. Sumanta (Monty) Pal  @montypal  Dr. Petros Grivas @PGrivasMDPhD   Follow ASCO on social media:     @ASCO on Twitter    ASCO on Bluesky   ASCO on Facebook     ASCO on LinkedIn     Disclosures:    Dr. Sumanta (Monty) Pal:   Speakers' Bureau: MJH Life Sciences, IntrisiQ, Peerview  Research Funding (Inst.): Exelixis, Merck, Osel, Genentech, Crispr Therapeutics, Adicet Bio, ArsenalBio, Xencor, Miyarsian Pharmaceutical  Travel, Accommodations, Expenses: Crispr Therapeutics, Ipsen, Exelixis  Dr. Petros Grivas: Consulting or Advisory Role: Merck, Bristol-Myers Squibb, AstraZeneca, EMD Serono, Pfizer, Janssen, Roche, Astellas Pharma, Gilead Sciences, Strata Oncology, Abbvie, Bicycle Therapeutics Replimune, Daiichi Sankyo, Foundation Medicine, Bicycle Therapeutics, Eli Lilly, Urogen Pharma, Tyra Biosciences Research Funding (Inst.): Bristol-Myers Squibb, Merck, EMD Serono, Gilead Sciences, Acrivon Therapeutics, ALX Oncology, ALX Oncology, Genentech Travel, Accommodations, Expenses: Gilead Sciences

He was hated, maligned, and marginalized. His enemies kicked dirt over his grave. His own people turned on him.  He dared to discipline in a permissive society. He dared to defy the zeitgeist, and to take the battle to the devil's back yard. He fought back against abortion and sexual perversion when everybody knew it would be a losing battle. He spent his wad advocating a highly marginalized homeschool movement, opposing godless public schools, and fighting abortion. He pushed for Christian legal defense organizations in an anti-Christian age. Dr. James Dobson was the man for the day — a quarterback fighting for every inch he could get, when pushed back to his own 5 yard line. He fought for a country through Roe v. Wade, Lawrence v. Texas, and Obergefell. He fought to save a civilization. . . a losing battle. He lost the pro-life plank. He lost the pornography battle. He lost the war on sexual perversion. But the point is. . .he fought with courage the whole way.  Here is our tribute to Dr. James Dobson (1936-2025).

The Cognitive Crucible is a forum that presents different perspectives and emerging thought leadership related to the information environment. The opinions expressed by guests are their own, and do not necessarily reflect the views of or endorsement by the Information Professionals Association. During this episode, Randy Rosin returns to the Cognitive Crucible to support his assertion that warfare is informational and the US Department of Defense needs an entirely new information paradigm. Recording Date: 28 Aug 2025 Resources: Cognitive Crucible Podcast Episodes Mentioned #7 Randy Rosin on Russia and Applied Cybernetics #187 Randy Rosin on Reflexive Control #125 Journey from conception through JP 3-04 Cybernetics: Or Control and Communication in the Animal and the Machine by Norbert Wiener Programming the Universe: A Quantum Computer Scientist Takes On the Cosmos by Seth Lloyd The Bit and the Pendulum: From Quantum Computing to M Theory--The New Physics of Information by Tom Siegfried The Information: A History, A Theory, A Flood by James Gleick Link to full show notes and resources Guest Bio: Dr. Randy Rosin was formerly a faculty member of the National Intelligence University in Bethesda, Maryland. He taught courses in propaganda, foreign information and cyber strategy, cyber threat intelligence, denial and deception, and leadership. He is a 32-year active-duty Army veteran who has served in combat arms, psychological operations, information operations, as a middle eastern foreign area officer, and in human intelligence operations. Notably serving as the information operations chief in Iraq, at US Central Command, and as the Senior Defense Official and Defense Attaché in Yemen.  His research interests are in the intersection of technology and manipulative communication and on the development of information-based theoretical frameworks in military applications. Currently he teaches critical thinking courses in the Honors College at Montana State University. About: The Information Professionals Association (IPA) is a non-profit organization dedicated to exploring the role of information activities, such as influence and cognitive security, within the national security sector and helping to bridge the divide between operations and research. Its goal is to increase interdisciplinary collaboration between scholars and practitioners and policymakers with an interest in this domain. For more information, please contact us at communications@information-professionals.org. Or, connect directly with The Cognitive Crucible podcast host, John Bicknell, on LinkedIn. Disclosure: As an Amazon Associate, 1) IPA earns from qualifying purchases, 2) IPA gets commissions for purchases made through links in this post.

A new MP3 sermon from Generations Radio is now available on SermonAudio with the following details: Title: The Legacy of Dr. James Dobson - A Paradigm of Courage, Sacrifice, & Faith Under Fire Speaker: Kevin Swanson Broadcaster: Generations Radio Event: Radio Broadcast Date: 9/2/2025 Length: 30 min.

A bug in Reth causes some Ethereum nodes to stall. The Ethereum Foundation announces the planned Holešky testnet shutdown. Twyne goes live on Ethereum. And The Ether Machine raises 150k ETH. Read more: https://ethdaily.io/774 Disclaimer: Content is for informational purposes only, not endorsement or investment advice. The accuracy of information is not guaranteed.

In this Big Ten Paradigm episode, Noah Drury recaps all the action from Big Ten Week 1. Rutgers opened with a solid win over Ohio, while Minnesota leaned on young talent to handle Buffalo. Nebraska's defense impressed against Cincinnati, and Wisconsin showed toughness versus Miami (OH). The spotlight, though, was on Ohio State, as new defensive coordinator Matt Patricia's unit dominated Texas in a 14–7 win. Buckeye standouts CJ Hicks and Jermaine Matthews Jr. highlighted how player development is paying off in Columbus. Michigan, Indiana, and Maryland all had notable debuts, setting the stage for an intriguing Week 2. Plus, guest Tyler Danberg of 97.1 The Fan breaks down Ohio State's win and what's next for the Buckeyes.This episode is sponsored in part by TicketSmarter:Use promo code LWOS10 to receive $10 off purchases of $100 or moreUse promo code LWOS20 to receive $20 off purchases of $300 or moreThink smarter.  TicketSmarter

Pastor Phil wrapped up our Multipliers series with such a powerful reminder: God's plan has always been to build Himself a family and a kingdom without end (Gen. 1:26–28).

Thank you for joining us at NorthRidge Church! For more information please visit us online at http://www.northridgethomaston.com.

In this second session of the Dogen Seminar, distinguished scholar Dr. Steven Heine explores the profound role of paradox in Zen Buddhism, examining how these seemingly contradictory teachings serve as liberating devices rather […]

Dr. Jeffrey Goldberg is Professor and Chair of Ophthalmology and Director of the Byers Eye Institute at Stanford University, a leading scientist in the development and degeneration of the visual system from eye to brain, and a practicing ophthalmologist and surgeon.This episode is brought to you by: Gamma AI design partner for effortless presentations, websites, social media posts, and more: https://gamma.app (use code TIM at checkout for one month off on their annual plan)Helix Sleep premium mattresses: https://HelixSleep.com/Tim (27% off on all mattress orders)AG1 all-in-one nutritional supplement: https://DrinkAG1.com/Tim (1-year supply of Vitamin D plus 5 free AG1 travel packs with your first subscription purchase.)Timestamps:[00:00:00] Start.[00:05:30] How do you solve a problem like presbyopia?[00:08:34] The athletic benefits of training supranormal (better than 20/20) vision.[00:11:49] Indigenous eye drops and FDA-approved pilocarpine for presbyopia.[00:14:05] Understanding basic eye anatomy.[00:17:27] Exploring AREDS 2, CoQ10, ginkgo, vitamin B3, and other supplements for vision.[00:23:00] Visual training devices and psychedelic-prompted brain plasticity.[00:25:12] Thoughts on visual training effectiveness and motor action requirements.[00:28:29] Concussion rehabilitation and visual perception exercises.[00:32:36] Red light and violet light therapy for myopia and mitochondrial health.[00:36:07] Vision loss correlation with cognitive decline and depression.[00:39:36] Presbyopia progression and psychological dependence on readers.[00:41:15] Cognito Therapeutics headset for Alzheimer's treatment.[00:46:46] Glaucoma basics: neurodegenerative disease and risk factors.[00:48:53] Eye pressure variability and diurnal cycles.[00:50:02] Cannabis effects on eye pressure and compound isolation.[00:51:47] Stem cell research for vision restoration.[00:53:09] Anti-inflammatory effects and immune system role in eye diseases.[00:55:15] Gut microbiome connection to glaucoma in animal models.[00:58:43] Metabolic syndrome and GLP-1 receptor agonists.[01:00:50] Microbiome sharing and future therapeutic possibilities.[01:03:31] Dry eye treatment: preservative-free tears and serum drops.[01:08:43] Vision screening recommendations and UV protection.[01:11:22] Full-spectrum light benefits vs. UV exposure.[01:13:27] Paradigm shifts: irreversible vision loss becoming reversible.[01:17:18] Convergence of neuroscience advances and biotech investment.[01:21:58] Miraculous mitochondria: health, transplants, and three-parent babies.[01:26:24] My family history concerns and metabolic health screening.[01:29:26] Exercise's biggest gain: going from none to some.[01:33:03] Clinical trial participation resources and parting thoughts.*For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast.For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsorsSign up for Tim's email newsletter (5-Bullet Friday) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Discover Tim's books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissYouTube: youtube.com/timferrissFacebook: facebook.com/timferriss LinkedIn: linkedin.com/in/timferrissPast guests on The Tim Ferriss Show include Jerry Seinfeld, Hugh Jackman, Dr. Jane Goodall, LeBron James, Kevin Hart, Doris Kearns Goodwin, Jamie Foxx, Matthew McConaughey, Esther Perel, Elizabeth Gilbert, Terry Crews, Sia, Yuval Noah Harari, Malcolm Gladwell, Madeleine Albright, Cheryl Strayed, Jim Collins, Mary Karr, Maria Popova, Sam Harris, Michael Phelps, Bob Iger, Edward Norton, Arnold Schwarzenegger, Neil Strauss, Ken Burns, Maria Sharapova, Marc Andreessen, Neil Gaiman, Neil de Grasse Tyson, Jocko Willink, Daniel Ek, Kelly Slater, Dr. Peter Attia, Seth Godin, Howard Marks, Dr. Brené Brown, Eric Schmidt, Michael Lewis, Joe Gebbia, Michael Pollan, Dr. Jordan Peterson, Vince Vaughn, Brian Koppelman, Ramit Sethi, Dax Shepard, Tony Robbins, Jim Dethmer, Dan Harris, Ray Dalio, Naval Ravikant, Vitalik Buterin, Elizabeth Lesser, Amanda Palmer, Katie Haun, Sir Richard Branson, Chuck Palahniuk, Arianna Huffington, Reid Hoffman, Bill Burr, Whitney Cummings, Rick Rubin, Dr. Vivek Murthy, Darren Aronofsky, Margaret Atwood, Mark Zuckerberg, Peter Thiel, Dr. Gabor Maté, Anne Lamott, Sarah Silverman, Dr. Andrew Huberman, and many more.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Today's blockchain and cryptocurrency news  Bitcoin is up slightly at $120,591 Eth is down slightly at $4,686 XRP, is down slightly at $3.28 Terraform co-founder Do Kwon pleads guilty to wire fraud and conspiracy Norway's soverign wealth fund has indirect exposure to over 7,000 bitcoin  Paradigm co-founder Matt Huang will serve as CEO of Stripe's stealth blockchain project. OKB jumps on tokenomics overhaul. Odin.fun exploited. Pantera Capital invests over $300M in BTC treasury cos Learn more about your ad choices. Visit megaphone.fm/adchoices