Podcasts about itrs

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Best podcasts about itrs

Latest podcast episodes about itrs

Will Run For...
Inside the Runner's Studio with Shelene

Will Run For...

Play Episode Listen Later Sep 30, 2024 21:13


This week on ITRS we speak to Shelene, a stay-at-home mom and autism advocate. She discusses her favorite runs, running shoes, and online pastimes. Shelene shares her love for the sound of her daughter's happy noises and her dislike for the sound of people popping their knuckles. She also reveals that she would attempt a creative profession and would not want to be a school bus driver. Finally, she expresses her hope that everyone she leaves behind is taken care of when she arrives at the pearly gates. . We're excited to continue getting to know members of the Will Run for Podcast Community in these mini episodes where we put the spotlight on you! To be featured as on a future episode email us at willrunforpodcast@gmail.com

Trail EAffect
International Trail Rating System (ITRS) for Mountain Biking with Mischa Crumbach and Edoardo Melchiori | 178

Trail EAffect

Play Episode Listen Later Aug 20, 2024 132:40


For Episode 178 We've got Mischa and Edoardo the two masterminds behind the International Trail Rating System. Mischa is based in Switzerland, and Edoardo is based in Italy. Both have a strong understanding about the nuance that goes into dissecting and rating a trail. While there is a lot that can go into how or why a trail is rated a certain way, this system is the most comprehensive approach I've seen for rating trails yet. Topics Include: How Mischa got into mountain biking How Edoardo got into mountain biking The International Trail Rating System and why The Survey about Trail Rating Four different Categories for Rating Trails Where the ITRS is Rooted – Safety and Decision Making Trail Builders take on Trail Ratings and the ITRS The width of a trail and how trail width factors in to how a trail is rated Becoming a Certified Trail Rater Implementation of ITRS Trailforks Having a 3rd Party rate trails What Mischa looks for in a good trail community What Edoardo looks for in a good trail community Closing Comments Trail EAffect Show Links: International Trail Rating System: https://itrs.bike/ Certified Trail Rater Training: https://itrs.bike/announcing-the-next-training-course-and-exam-to-become-a-certified-trail-rater/ Swiss Bike Park: https://www.swissbikepark.ch/ ITRS and IMBA Europe: https://www.imba-europe.org/knowledge-hub/international-trail-rating-system-itrs/ ITRS on LinkedIn: https://www.linkedin.com/company/international-trail-rating-system/ Trail Therapy: https://en.trailtherapy.ch/   Episode Sponsor - Coulee Creative: www.dudejustsendit.com https://www.couleecreative.com/ Loam Pass Affiliate Link: https://www.loampass.com?utm_source=affiliate&utm_medium=track&utm_campaign=traileaffect Loam Pass – Free Pass Protection Code: TAPOD Trail One Components 20% off Coupon Code: trailpod Trail EAffect Podcast Website: www.traileaffectpodcast.com KETL Mtn Apparel Affiliate Link: https://ketlmtn.com/josh Trail One Components: https://trailone.bike/?ref=XavfBrRJfk4VOh Contact Josh at evolutiontrails@gmail.com This Podcast has been edited and produced by Evolution Trail Services

Inside The Recording Studio
Discovering the Ultimate Audio Magic with the TC2290 Deep Dive

Inside The Recording Studio

Play Episode Listen Later Aug 11, 2023 28:08


Chris and Jody go round and round, side to side into a deep dive of the TC2290 Digital Delay unit. As per all other deep dives on ItRS it's a history of the unit. Also taking a look at the interface and all the modules and what they do on this incredible sounding hardware delay.

The DEI Discussions - Powered by Harrington Starr
The DEI Discussions #HumansofFinTech | Kieran Stewart, Global Head of Service Delivery for ITRS Group

The DEI Discussions - Powered by Harrington Starr

Play Episode Listen Later Apr 27, 2023 8:08


Joining Nadia live from FIX Trading Community EMEA Trading Conference for this episode of The DEI Discussions is Kieran Stewart, Global Head of Service Delivery for ITRS Group.Volatility, disruption and variability appear to be synonymous with the trading space — and Kieran helps us explore the positive connotations of this environment. There is an exciting future on the horizon, and ITRS Group are at the fore of this.But what will take this space to a new level?Diversity: diversity of voices; diversity of input; diversity in leadership. To make the technology of the future a future-proof concept, it needs to reflect the inclusive landscape that is emerging. Making this a reality is not a straightforward task but for Kieran, it starts with looking critically at our talent acquisition strategies.Thank you Kieran for joining us on the Humans of FinTech Podcast! Learn more about the FIX Trading Community and their upcoming events here:https://www.fixtrading.org/fix-events/

IBS Intelligence Podcasts
Ep580: Managing risk and resiliency issues as the ‘great wealth transfer' gets underway

IBS Intelligence Podcasts

Play Episode Listen Later Apr 26, 2023 10:32


Guy Warren, CEO, ITRSThe financial services sector is witnessing a ‘great wealth transfer' as funds and assets move down the generations to millennials and Gen Z, bringing heightened expectations.  The two groups have higher expectations for customer service and are tech-savvy. Banks and financial institutions need to have ‘bullet-proof' operating systems in place, according to Guy Warren, CEO of performance monitoring solutions provider ITRS. He tells Robin Amlôt of IBS Intelligence that the role of technology in meeting these generations' expectations when it comes to wealth management will be key.

Inside The Recording Studio
Autotune Secrets Revealed: Inside Look at the Best Tuning Software and Plugins

Inside The Recording Studio

Play Episode Listen Later Feb 3, 2023 33:25


Chris and Jody hit the autobahn of decisions. To tune or not to tune vocals or other instruments, that is the question. It's a subject many don't like to chat about. It's also an important part of modern music's DNA. What does the ItRS duo do? What do they use? What are the major players in the world of tuning? It's all here and a little bit more.

SAG Infotech - A CA Software Company
Brief Summary of Genius Tax Return Filing Software on G2 Website

SAG Infotech - A CA Software Company

Play Episode Listen Later Nov 8, 2022 1:22


Gen IT, Gen BAL, Gen TDS, Gen CMA, Form Manager, and AIR/SFT are six of the modules included in Genius, which give unlimited tax return filing. There are many features in the software, including online PAN/TAN verification, import of JSON/Filled ITR Data, quick ITR upload, E-payment of Challans, importing AIS, TIS, 26AS forms, and MAT/AMT calculation. It will be very convenient and easy for taxpayers to file their ITRs. Tax return software also offers a variety of audit forms, including 3CA, 3CB, 3CD, 10B, and 10A. Therefore, we have also published a complete explanation of Genius software on the G2 website. https://www.g2.com/products/genius-software/reviews

Inside The Recording Studio
Strymon BigSky Reverb. Why You Need To Know About This Amazing Plugin

Inside The Recording Studio

Play Episode Listen Later Nov 4, 2022 36:48


Chris and Jody get an early bird worm look at a new reverb plugin, BigSky from Strymon. This is Strymon's first foray into the world of plugin computing and what better way to introduce itself to your DAW and digital rig setup than with the luscious BigSky? Chris and Jody discuss putting the plugin thru it's paces. An in-depth look at all the reverb playgrounds. Plus an extra deep dive into several of the playgrounds and how they make the BigSky Reverb unique. And for a first time ever for ItRS, we have some audio examples to showcase the BigSky - head over to insidetherecordingstudio.com to listen. 

SAG Infotech - A CA Software Company
Check ITR Refund Status with Easy Process Via E-filing Portal or NSDL

SAG Infotech - A CA Software Company

Play Episode Listen Later Sep 28, 2022 2:34


For the Assessment Year (AY) 2022–23 and the Financial Year (FY) 2021–22, the last date to file ITR was 31 July 2022. Many people, submitted their tax returns. In accordance with the information available on the income tax website, over 6.16 crore ITRs were filed by 11th September. More than 5 crore ITRs are already managed by the tax department. Assesses are most likely to get a tax refund after furnishing their returns. Tax refunds were not received by some assessees. There are many reasons for IT refunds to be late. Therefore, we are providing a simple and easy process for ITR refund status on the NSDL website or the new income tax e-filing website. For more details: http://saginfotech.wikidot.com/process-check-refund-status-itr-portal-nsdl

Why Not Mint Money
How to disclose income from investments and trading in ITRs

Why Not Mint Money

Play Episode Listen Later Jul 28, 2022 26:21


Mint's Satya Sontanam speak to Tapati Ghose, Partner, Deloitte India to understand the tax rules and the reporting requirements of capital gains on stocks and mutual fund units.

Dental Digest
125. Dr. Christian Coachman - Digital Smile Design

Dental Digest

Play Episode Listen Later Jun 6, 2022 34:37


Dental Marketing with Legwork Podcast Website Follow @dental_digest_podcast Instagram Follow @dr.melissa_seibert on Instagram Connect with Melissa on Linkedin Dental Digest Podcast Facebook Digital Smile Design My guest this week is Dr. Christian Coachman and we'll be talking about Digital Smile Design.  Transcript:  Speaker 2: [00:01:56] So I'm here with Christian Coach and I'm a huge fan of your work. I'm a huge fan of what you've done for digital dentistry and integrating it into dentistry. I'm a big fan of just everything you've brought. So would you just start by telling us your story? You have a bit of a unique story. [00:02:11][15.4] Speaker 1: [00:02:12] Thank you for having me here. Great pleasure to participate and share a little bit of my story. And so my story starts in Sao Paulo, Brazil, where I was born and raised, where I went to dental school at the University of Sao Paolo, where I did my dental technician course as well. And in starting in 95, I started to work as a technician for my father and then started to work with other Brazilian doctors. And I was able to grow into this position as a dental technician, creating a certain reputation in Brazil. And because of that, I was invited in 2004 to join Team Atlanta in the US was a big move for me at that time, became their head ceramicist and worked there for almost five years. And of course I was able there as well to pursue another passion of mine that is lecturing and teaching. Since they were all very well-known speakers, I was able to to learn from them and to also they opened doors for me and I started to lecture all over. And during that time as well, I started to develop the concept of digital smile design. That was basically a concept of improving the dentist technician communication, and it grew into something much bigger. And that was 2007 eight nine, when social media was growing. I was able to get that wave and really be one of the first ones to start promoting my work in social media. That took me all over the world and travel a lot. From 2009 to 2014 into 2014, the DST concept got a little bit more mature and 3D technology started to kick in and we then partnered with software company and developed the center here in Madrid. My two brothers. Then I was able to convince my brothers to join the project and moved to Madrid to start running the project here since I was traveling all over. The project grew and two years ago I moved with family here to Madrid as well. And that's exactly what I'm speaking now from my home in Madrid. [00:04:38][145.9] Speaker 2: [00:04:39] And so I've heard a little bit about your story from our mutual friend Dr. Bill Robbins, also a big fan of his work. And he said that effectively what you've created all kind of started because you were trying to find a way for the dentist to better communicate with you and to have better back and forth communication. [00:04:55][16.2] Speaker 1: [00:04:57] Mm hmm. Yeah. I remember many years ago, I was hearing I was reading somebody talking about communication outside dentistry, and they mentioned that two thirds of all the problems in human history are related to bad communication from family problems all the way to world wars, the lack of communication skills. So I was always very passionate about communication that combined with my passion for teaching. And I realized that a lot of our problems, they come from not being trained on communication strategies, dentist, technician and also anticipation. So I started to really absorb and analyze the communication process and started to develop ideas on how to improve that dentist technician communication, to improve efficiency, to understand, to pass better information and to minimize errors and to save time in the patient's mouth, basically. And then on the other side with the patient, improve communication with the patient to calibrate expectations and to create perceived value, to differentiate yourself, to increase case acceptance, to to sell better, more comprehensive dentistry, things that we are usually not trained in dental school. So the DST concept is basically focused on those two things, what I call digital dentistry and emotional dentistry. Digital dentistry based on this creation of smart systems to improve the flow of the information and emotional dentistry, everything that we can do to make patients value us more and understand the importance of what we do. Of them. [00:06:56][118.9] Speaker 2: [00:06:56] So would you start by telling us of what is digital smile design? I mean, this is one of the concepts that you lecture about globally. [00:07:03][6.5] Speaker 1: [00:07:04] So Digital Smile Design is, is this name that I created to 2009, so 13 years ago now known as DSD. As I mentioned, started in a more technical way for me. Initially, my my idea was to help me as a dental technician work with less stress and be more efficient. Right. So I started to analyze the common mistakes that I was I was doing. And even though I was working with some of the best dentists in the world, and I was a very good technician myself, I realized that we were all making some mistakes, repeating some mistakes, and DST started as a bunch of techniques and workflows to improve the way the information was coming from the patient to the dentist, dentist technician technician back to the dentist, dentist into the mouth. So I wanted to be more efficient. I wanted to waste less my time. I wanted to work less and make more money. And to be honest, so that's how it started. But I naturally started to understand that at the end of the day, it doesn't matter how much more efficient you become, the effort that you put to be more efficient, the patient needs to value that because at the end of the day, they need to pay for it. They need to sponsor your investment in being better. So I realized that the best way to convince people to incorporate my ideas of better systems was to help the doctors create more value towards the patient. So this is when I coined the term emotional dentistry and it became all these strategies that makes us different from the patient's perspective, makes us special from their perspective. How can you make the patient say Wow, for all the little things that you do for them are even more challenging? How can you make them say Wow even before you start the treatment? So how can you become the best spokesman of yourself, of your team? Of the amazing things that you can do for people? How can you incorporate visual communication principles, storytelling technique into the way you sell yourself? You sell your treatments, the way you create your brand, the way you make this experience be wonderful for the patient. Since patients usually don't like to go to the dentist, I realized that we had a huge opportunity to completely change the experience of going to the dentist. [00:09:53][168.6] Speaker 2: [00:09:54] And so, of course, you know, in this podcast, people are only kind of getting a brief window into some of what you teach, but how do you do that? How do you implement this emotional dentistry and how do you change patients expectations and how do you communicate with patients to get them to say, wow. [00:10:10][16.1] Speaker 1: [00:10:11] So, of course, this is this is exactly the main topic of what we teach on the course, right? So we divide the concept into two, five steps design, plan, present, perform and lead. So how to use technology to understand better the link between the face and the smile and avoid mistakes? And then how do you make the patient value that? How do you use technology and communication systems to take advantage of collective intelligence, cloud dentistry and make better decisions for the patient? So how can you use technology to make better decisions every single day for every single patient? How do you use technology, storytelling and visual communication to improve the way you present the plan, the way you make the patient embrace the plan, the way you make the patient change their priorities, the way you make the patient, make dentistry priority number one. So that's number three. Number four, how to use technology and teamwork to improve the execution of dentistry in a more streamlined way, in a more predictable way. Delivering delivering outcomes that are more similar to the initial projects that you offer to the to the patient. So how do you bring this close, this gap between what you show at the beginning and what you deliver at the end of the treatment by using technology and what we call guided dentistry and digital quality control. And at the end, how do you become a better leader? Because the magic or the. Happens if you have a great team. How do you build your dream team as a dentist? To make this whole magic happen? So these are the five pillars of the content that we share on our courses. Design better smiles, plan better your cases present and sell better your treatments, execute with more precision efficiency and become a better leader. Empower your team. So this is basically the DST concept. [00:12:25][133.8] Speaker 2: [00:12:26] What are some of the technologies that you're using to design these smiles? I mean, would you give us practical examples of what you're doing? [00:12:32][6.0] Speaker 1: [00:12:32] So of course that to design, to deliver better smiles to our patients, we need to follow up. We need to follow these steps. So the first the first step is to rethink the way we gather the information. What technologies can we use to understand better the human being sitting in front of us? So of course using scanners, you know, using CBC DS, but using videography, using all kinds of new technologies that can understand better. The problems of the patient sitting in front of us and of course, also fascinate the patient. So so these two things come together on the floor, right? It's being more efficient, delivering better care, and at the same time, simultaneously fascinating the patient doing each one of these steps, you know. So the first step is acquiring better data, using all the technologies that are available today that are usually underutilized by most doctors. So we teach doctors about the technologies available. And more important is not only about buying these technologies, but is about knowing how to take full advantage of these technologies so you get the return on your investment. Then the second step is how do you use technology to make better decisions? And that is utilizing simple cloud based chat systems and info sharing systems, you know, data sharing. So you can pick the brains of people that can help them make better decisions. So this is what we call cloud dentistry, asynchronous communication and collective intelligence, and using simple platforms that are available, many of them for free. Incorporating this in your daily routine to constantly be uploading your patients in the cloud and allowing the team to brainstorm in an a synchronous way so you don't waste your time. So that's number two. Number three is utilizing 3D software to simulate your ideas. So test driving your ideas before touching the patient. This is a big thing for us. You know, it's like the flight simulator that allows pilots to make mistakes virtually before they kill people for real. So we say you need to use 3D technology not to execute the treatment, but to test drive the treatment before you execute. So simulate your ideas. Make sure you are having the best ideas, compare ideas and use 3D technology to understand better the pros and cons of each one of the options that you are imagining for your patient. I say make mistakes in the computer to avoid mistakes in the mouth. Right. So this is the third pillar of how technology can help us that. The fourth pillar is patient education, patient motivation, expectation, calibration, but also creating excitement. So that means that we we use visual communication tools, digital technology to present better in a much more exciting way. You know, usually the way then does of presenting treatments are kind of boring, kind of nothing special, and we reinvent completely the way we present treatment plans. I usually tell them, General, you need to become the Steve Jobs of your treatment plan the same way Steve Jobs was presenting his first iPhone. You know, watch that video. And in 5 minutes, he was able to move the whole world into believing and batty on that broad project. Right. So when you build a nice treatment plan, you need to use all these strategies to present this treatment plan if you want to really differentiate yourself. So that is pillar number four. And then pillar number five is the treatment itself. And this is when we use 3D software's and printing technology to perform what we call guided dentistry. What I see is that in the near future there will be very few free hand procedures in dentistry. Everything is going to be guided and is very obvious why this is going to happen. You know, first, because patients love the idea of guided them to three. It's a much better way to sell a procedure. They feel safer. You can tell amazing stories about why guided dentistry diminishes the risks of errors and so on. So it's a great story. It's great for your business and it's of course also great for dentistry because you create more predictable results. So we talk about Guide to Dentistry and how to use digital quality control with 3D softwares. And then the final point is leadership and team building. And then we bring smart platforms from the business world on how to incorporate this into your clinic, to analyze the the vibe of your office, how your staff is actually evaluating your work and your leadership, and how pleasant it is to work in your office. And how can you create and transform your office into the best place to be working and and really make people see that they have a future, they have a career inside your your project. [00:18:05][333.2] Speaker 2: [00:18:07] So many, Dennis, are just using stone models mounted on articulation and then wax to present treatment plans. And this can be incredibly problematic if you're trying to convince a patient of a 30 or $40,000 treatment plan, wax just doesn't translate to the tangible outcome to the patient. You know, and this is primarily what you teach. Would you tell us more about why this way of presenting a treatment plan can be flawed? [00:18:28][21.5] Speaker 1: [00:18:29] The first thing you know, I did a test. You know, in my old days when I was a dental technician, I showed to a patient a beautiful, properly done wax up. And then I showed the patient a horrible, ugly wax and they had no clue which one was the right one and which one was wrong. So patients don't understand waxes, and even when they shake their hands and they say, I got it, they didn't. They just don't understand. By the way, patients usually don't understand most of the things that dentists are saying to them. We have this tendency to speak as a dentist, to speak, you know, we were trained to talk about dentistry to other dentists, and then we kind of talk to patients in a similar way. And we believe they are they understood, you know, they're shaking their hands because they are under pressure. They're they don't want to you know, he's the doctor. I need to pretend that I'm understanding or whatever. So we need to change completely. You know, we need to study a little bit human behavior and communication strategies. The key for me is to engage emotionally and communicate visually. So engaging emotionally means that, you know, you train, you practice communication and listen, you picking the right words to connect with people. And this has nothing to do with dentistry, right? We know people that are much better with that, other people that are not that good. So you need to practice that. Somebody, the person in your office that is the one presenting treatments needs to understand how to engage emotionally through communication. The other thing is visual communication, meaning that you need to explain things visually and we need to use what we have. The best tools that we have and the best tools we have nowadays is 3D technology. And it's just interesting to see that the few doctors that are using 3D technology, they're only using after they resold the treatment. So they sell the treatment and then they're going to use 3D technology to do whatever they want doing the treatment. And I'm telling people this is not smart because at the moment we need more help, is not on the treatment. Execution is on the treatment building and the treatment selling. Making the plan and convincing somebody to pay for the plan. These are the two most challenging moments in dentistry, right? And nobody talks about it or very few people talk about it. So we focus on that moment, how to build the best plan and how to communicate that plan, how to convince the patient to invest in that plan. These are the two key moments to have a great business in dentistry. [00:21:26][177.2] Speaker 2: [00:21:27] When you're actually bringing those wax hopes to the patients are the, you know, the digital sculpting, what you've done, are you showing them screenshots of what you've done or are you actually having them sit there in front of the software with you and walking them through and letting the patient make suggestions and then making adjustments accordingly? [00:21:44][16.5] Speaker 1: [00:21:45] So the way we present the plan, we actually divide the presentation in three moments. We call it the the emotional phase, the problem phase and the solution phase. So this is how we structure the way we present the treatment plan. By the way, this is the way I structure any type of communication in my life, even outside dentistry. Connecting emotionally, then. Explaining. That there is a problem somewhere and you can you can help with the solution and then explaining the plan and the solution. Right. So you need to first engage emotionally with the patient or make the patient engage emotionally with the treatment. That's the first step to make people change priorities. People are coming to you. And dentistry is one of the lowest priorities in their life. They're going to try to find any excuse not to invest on what you are about to present. So we need to know that we have a client that is there trying not to pay for what we going to present. So the only way to make people change priorities is to understand that we humans, even though we think we are rational beings, we are actually much more emotional. So the first step is to gain emotional credit, to even start any conversation. If you don't gain emotional credit, people will not listen to you. Then after you gain emotional credits, you need to then emphasize the problems, emphasize the findings before you explain solutions. This is another common mistake. Since we know the problem and we know the solution, we tend to jump the problem and we explain the solution. That's what you need. Basic vision. You need this. And when we say you need this, we are not allowing the patient to value that solution because they don't understand the problem. So they they know it's very hard to value a solution if you don't understand the problem. So the step number two is to deep dove into the problem journey as we call. And for that problem journey, we use the technology. So we we bring our scanners. We open the scanners in front of the patient. We connect the scanner to a huge TV so they can see everything very big. And with touch screen, we can show in 3D everything that we found. We show the CBCS, we show the face, we show the videos, the images, the x rays. But we connect all these visuals in a very dynamic way to give a complete list of everything that we were able to find as an issue or a possible issue or something that can be improved. So now after they they they went through the emotional journey first. And the emotional journey that we didn't mention is basically what we call the emotional smile test drive, where we do the facial scans, the infrared scans, and then we do the 3D design, we print this design and we place it in the mouth. And without saying anything, we record the before and the after and we present this. So we use 3D software and printing technology to generate the emotional smile test. Right after those ten, the ten minute, 50 minute experience, we go into the problem journey, we use the scanners, the CBCS, the videos, the images, etc. and we go through this deep, dove into all of the issues that we found. And then only after that we get into the treatment presentation. So now that you have, you know, where you want to be with the smile test, right? You know, the problems that you have with this journey, this digital journey through your issues. Now you can validate the plan. And this is the plan that we want to explain to you at that point. What we do is that the lab will create because the lab has the software, the dentist doesn't have the software. So the lab creates a presentation for the dentist with great maps, screenshots and videos from the software and organizes into a storyline. So the dentist can then present this in 3D as if they had the software without having to have the song. [00:26:04][258.7] Speaker 2: [00:26:04] I love that and I think what you've talked about with actually taking time to present the problem can't be emphasized enough. I'm very much so guilty when I'm presenting treatment plans of just immediately jump to this is what we're going to do for you. This is what's involved in this. And, you know, it's no wonder that at times I'm failing to have a little bit of buy in from the patients where perhaps at that point they're just defaulting. To my expertize, I'm sure I'll venture to say my treatment acceptance is reasonable. I'm not getting a considerable number of people declining treatment, but yet at the same time, how powerful would it be to really spend that time investing with the patient and enumerating for them what the problem list is. [00:26:41][36.3] Speaker 1: [00:26:41] Is so many ways, you know, because we are not dentists are usually not focusing on that because we were trained to focus on the treatment itself. You know, we know that at the end of the day, we need to deliver good quality care. And that is of course the most important part. So we are usually driven to put energy on that, the clinical execution, so we don't take much care of building the plan and selling the plan. We were not trained. We we don't have the natural skills for that. So this is why, you know, it's so important to focus on that if you are already and I always say that if you are already a good clinician, you're ready to come to a DC course and learn how to make the magic happen. [00:27:25][43.4] Speaker 2: [00:27:25] So why are you using. Videography when you're gathering data, that's a bit unique. [00:27:30][4.1] Speaker 1: [00:27:31] Yeah, this is something that we also brought to to restorative dentistry is amazing today to realize it until ten years ago, nobody was doing videos, you know, for us is a mandatory piece of information because the beauty of the smile comes from the movement. A beautiful smile is a beautiful smile in the real life. In real life is moving. You know, you don't want to look just good on a static photo. You want to look good in real life. So we need to analyze faces. We need to analyze the motion of the face. We need to analyze the motion of the lips. We need to analyze the motion between the teeth and the lips. So the only way to do this is through video. Video also captures the patient's emotions. The video captures the patient explaining what they like and what they don't like. Video allows you to understand a little bit of the character of that human being. The video allows you to also understand phonetics, understand the way that job movement is happening so you can see function from a different perspective. So I don't know, in like a one minute video, you can have so much information. And besides that, every second of a video brings an average of 30 photos. There's 30 photos inside every second, all of you. So it means that when you make a one minute video, you have hundreds of photos that you can pause this video in all of these moments and make a print screen. You make a screenshot of that and create a whole documentation out of the video. So for us is mandatory. All the dentists that work with us as part of the basic initial documentation, the video of their face, the patient's face in this interview, the video of this interview, this interaction is a mandatory piece of documentation for us. [00:29:21][110.8] Speaker 2: [00:29:22] And not only that, but certain critical measurements that are really important for small design, such as incisal display or how much gingiva they show when emoting. You really can't gather in a photo or just even chair side because oftentimes it's very artificial. How often, when you're asked to smile, are you truly giving your true smile? Whereas in videography you can actually see them emoting. You can see how much ginger is displayed. [00:29:43][21.5] Speaker 1: [00:29:44] Exactly. You know, for example, you mentioned the rest position, the real rest position, understanding the relationship between the wrist position of the upper lip and display on the teeth. We know how important this initial analysis is for treatment, planning, for decision making. Right. And many times when you ask the patient to rest and you take a picture, you know, the patient moved a little bit the lip, and then you have that picture and you think that is the best position. So I don't like to analyze the lip rest position in photos. I always analyze the lip rest position in the view and I move slowly. Video until I can capture the moment where I can see the muscles completely at rest. You can see that on the video, and then you pause and you can make a prescreen and say, okay, this is my real rest position. The same thing with the full smile. Another information that we know is key, you know, and you and me as fans of Bill Robbins in his book Global Diagnosis. It's the whole book. It's all about these two pictures. It's like the starting point comes from these two pictures. And if you capture these two moments wrong, you're going to make wrong decision. So when you ask the patient to actually give you a false smile and you click your picture, usually the patient is not getting your full smile, right? So the patient can usually show around 30% more of gum than what they show on that picture. So it's not a good starting point in the video. On the other hand, if you play the video you have, if you're recording the video, the patient after a few seconds forgot about the video. You know, you see something funny, they're interacting with you, they laugh. And you captured that moment when the patient really forgets about the video, loser loses it up and moves the leg all the way to the top. And you can then see that the exact lip designed, the way the lip moves and how much exposure you really have on that patient. [00:31:48][124.0] Speaker 2: [00:31:49] What are your thoughts on face photos? Why might this not be a very accurate way to capture data when we have other tools available? [00:31:56][6.5] Speaker 1: [00:31:57] And this is a good point. You know, I mean, I've been for 14 years, I've been bringing topics into my lectures that many times. You know, people wanted to to kill me. You know, I remember when I ten years ago, I said that the iPhone would become one of one of our major meditation tools, you know, and I posted it on Facebook and and people wanted to kill me, you know, so many bad comments that you're crazy. You shouldn't say that. And nowadays everybody uses. You know, the way, you know, we were the first ones to talk about a monolithic esthetic restorations with high quality. And for many years, people were saying this is impossible, and now everybody's doing it. And the other the other topic, you know, byte registrations with scanners that we were talking about. But registrations will disappear, you know, because you're going to scan the bytes and you're going to remove all the distortions of byte registrations and mounting models on that particular ITRs with that, all the mistakes that we did for decades, you know. So and nowadays everybody's registering by the scanners. And the other topic that for many, many years people would go crazy would be this is the is the Facebook, right? Because I've been telling people since 2014 that the Facebook is completely useless and it is completely useless. There's absolutely no reason. Not even one reason for that is to do a Facebook. If they work with the lab that understands CAD software, if your lab understands CAD software, all you need is an iPhone photo of the face and an integral scan. So if you have facial photos in an inch or scan, you can do a much better job on the software than trying to transfer a Facebook to an articulator. So this is it's pretty young people. Of course, people have a hard time accepting things that they usually don't even want to think about it because it's something new and they fight against the new. But I was able to convince all the major presidents that I have a good relationship. And nowadays it's a common sense. You don't need Facebook's. [00:34:14][137.4] Speaker 2: [00:34:19] You guys, believe it or not, ratings on the Apple Podcast app actually really matter. So if you benefit from this podcast, could you please be sure it's liberating and subscribe? And as always, send me direct message and podcast Instagram, which is Don't buy this podcast. All right. I'll see you next week. [00:34:19][0.0] [1918.5]

CMC Podcast
E23 - MRA Part II

CMC Podcast

Play Episode Listen Later Dec 29, 2021 40:39


We apologize for some background chatter in the first several minutes of this episode. It is cleared up after 5:301:35 Standards as they relate to the MRA.15:30 To prepare for accreditation and make sure teams mission ready, what types of training does the MRA offer?23:38 What was/is MRA's role in NATRS (North American Technical Rescue Symposium) which is now ITRS?31:38 How is MRA involved with ICAR (International Commission of Alpine Rescue)?37:55 Closing statements.Links:MRA website: https://mra.org/MRA Mission Database: https://experience.arcgis.com/experience/6b84b11fc6eb495ea518ee964b79f712/MRA Education Basecamp: http://training.mra.org/YouTube Channel // MRA Third Thursdays: https://www.youtube.com/channel/UCr2Fnsp_xZ6OrcKQgQRX2PgMRA Annual Spring Conference: https://mraconference.org/Important WarningMany of the activities discussed in this podcast pose a very substantial risk of serious injury or death.Products and techniques discussed in this podcast are intended for use by specially trained professionals.Technical rescue, rappelling, climbing and the training involved are very hazardous activities. Each situation has its own unique conditions and must be evaluated by those present. Effective risk management comes from experience, proper training and good personal judgment.CMC is not liable for any damages arising from abuse or improper use of the techniques or equipment discussed in this podcast.Topics discussed are the ideas and opinions of each individual.Department protocol and regulations should always take precedence.

CMC Podcast
E22 - NASAR Part II

CMC Podcast

Play Episode Listen Later Dec 15, 2021 47:53


0:23 Chris Boyer introduction1:12 John McKently introduction2:35 Standards, training, certification.16:00 Examples of how NASAR builds educational content20:53 How do you select who your trainers and evaluators are going to be?38:52 Has new technology driven change in the lifecycle of certification?40:20 Hug-a-tree NASAR general public education.Links:www.NASAR.org Important WarningMany of the activities discussed in this podcast pose a very substantial risk of serious injury or death.Products and techniques discussed in this podcast are intended for use by specially trained professionals.Technical rescue, rappelling, climbing and the training involved are very hazardous activities. Each situation has its own unique conditions and must be evaluated by those present. Effective risk management comes from experience, proper training and good personal judgment.CMC is not liable for any damages arising from abuse or improper use of the techniques or equipment discussed in this podcast.Topics discussed are the ideas and opinions of each individual.Department protocol and regulations should always take precedence.

CMC Podcast
E21 - Thanksgiving Special

CMC Podcast

Play Episode Listen Later Nov 24, 2021 38:47


Thank you to all of our podcast listeners! As we gather with loved ones and slow down for the holiday it's a good time to share about the things and people we are grateful for. In this Thanksgiving Special episode CMC instructors discuss what they're grateful for around technical rescue including testing methodologies, new ways of sharing knowledge and the people who have impacted their careers and driven the technical rescue world forward. Enjoy!

Business Standard Podcast
Demonetisation, 5 years on: Key economic indicators paint a mixed picture

Business Standard Podcast

Play Episode Listen Later Nov 8, 2021 5:31


On November 8, 2016, Prime Minister Narendra Modi had announced ‘demonetisation' to weed out black money from the country. The move, which saw the currency notes of Rs 500 and Rs 1,000 denominations getting banned, wiped out 86% of India's currency overnight.   The currency with the public, which stood at Rs 17.97 trillion at the time, declined sharply to Rs 7.8 trillion in January 2017, soon after demonetisation. A few months later, of the Rs 15.41 trillion which had been demonetised, Rs 15.31 trillion came back to the RBI. So, more than 99% of the demonetised currency notes were returned to the banking system.   Large cash deposits have given rise to inquiries from probe agencies like the I-T Department and the Enforcement Directorate against millions of account holders. The government's efforts on this front remains a work in progress. A few months ago, the RBI asked banks to not destroy the CCTV footage of their branches from the demonetisation period.   What is the status five years later?    THE FIVE KEY INDICATORS   1. Cash still rules: Circulation touched all-time high of Rs 28.3 trillion on October 8 2. Digital transactions: These, including UPI, have also touched an all-time high 3. No. of UPI transactions: Up from just 0.29 million in Nov 2016 to 4.2 billion now 4. Value of UPI transactions: A record high of $103 billion last month 5. Currency in circulation: Growing in line with nominal GDP growth   Reserve Bank of India data show that the cash in circulation as on October 8 this year reached an all-time high of Rs 28.3 trillion, proving that cash is still the king. This figure is 57% higher than the level seen right before demonetisation. The demand for cash also increased ahead of the festival season. The currency in circulation has been growing in line with nominal GDP growth.   As a percentage of GDP, too, the cash in circulation has jumped sharply from 8.7% in FY17 to 14.7% in FY21.   At the same time, the government's efforts to digitise the economy have also borne fruit. The number of transactions done through the Unified Payments Interface (UPI) has seen an exponential rise since demonetisation – from just 0.29 million in November 2016 to 4.2 billion now. The value of UPI transactions touched a record high of $103 billion last month.   Reducing India's dependence on high-value notes was another goal. But data from RBI's latest annual report show that the share of high-value currency notes like those of Rs 500 and Rs 2,000 in terms of volume increased to 33.1% by the end of financial year 2021 from 9.2% in FY17. One in three notes in circulation as of March 2021 was of Rs 500 denomination. In FY16, the share of high-value notes like Rs 500 and Rs 1000 was at 24.4%.   One indisputable fact, however, is the formalisation of the economy in the past few years. A report by State Bank of India's economic research department last month said that India's informal economy shrank during the pandemic year. The research showed that the country's informal economy contracted from 52% of GDP three years ago to 15-20% in FY21. Although the pandemic caused most of this transformation as the informal economy was the worst hit, some of it has been due to demonetisation and the implementation of GST.   On the long-term changes that have happened since demonetisation, N R Bhanumurthy, economist and vice-chancellor of BR Ambedkar School of Economics, said:   Formalisation not just because of demonetisation Increase in online transactions, GST led to formalisation Formalisation came at the cost of informal sector ITRs, employees in formal sector rose after note ban Covid-19, lockdown increased cash in hands of people If informal economy shrank, black money would have come down too

CMC Podcast
E20 - What is MRA?

CMC Podcast

Play Episode Listen Later Nov 3, 2021 59:16


0:24 Doug McCall Introduction2:09 Monty Bell Introduction3:51 John McKently Introduction5:20 History of the MRA10:45 What is the accreditation process for the MRA?18:27 Reaccreditation19:40 What training opportunities are offered through the MRA?23:40 California reaccreditation31:17 MRA statistics program38:35 MRA Basecamp online outdoor education42:37 Medical protocols45:37 Medical communication resources46:55 What's next for the future of the MRA?54:35 Closing thoughtsLinks:MRA website: https://mra.org/MRA Mission Database: https://experience.arcgis.com/experience/6b84b11fc6eb495ea518ee964b79f712/MRA Education Basecamp: http://training.mra.org/YouTube Channel // MRA Third Thursdays: https://www.youtube.com/channel/UCr2Fnsp_xZ6OrcKQgQRX2PgMRA Annual Spring Conference: https://mraconference.org/Important WarningMany of the activities discussed in this podcast pose a very substantial risk of serious injury or death.Products and techniques discussed in this podcast are intended for use by specially trained professionals.Technical rescue, rappelling, climbing and the training involved are very hazardous activities. Each situation has its own unique conditions and must be evaluated by those present. Effective risk management comes from experience, proper training and good personal judgment.CMC is not liable for any damages arising from abuse or improper use of the techniques or equipment discussed in this podcast.Topics discussed are the ideas and opinions of each individual.Department protocol and regulations should always take precedence.

CMC Podcast
E19 - What is NASAR?

CMC Podcast

Play Episode Listen Later Oct 20, 2021 50:32


0:20 NASAR Executive Director Chris Boyer introduction.1:37 John McKently introduction and involvement with NASAR.3:54 What does search look like in the US today?7:57 How did NASAR get started?10:54 When did the organization start expanding eastward?13:42 Are there any states that put SAR in the hands of fire from a legislation standpoint?18:28 What's the difference between SAR and USAR?25:19 Mass rescue operations and wide area search.26:45 What is NASAR doing to promote good legislation to get good uniformity across states?29:57 How do you come up with a uniform standard of care and response?33:03 Special challenges in National Park areas.35:22 The need for a national database around SAR.37:25 Volunteer SAR protections.42:34 How important is it for each state to have a point person for SAR organization.44:50 What's the future of NASAR?47:56 Closing thoughts.Links:www.NASAR.org Important WarningMany of the activities discussed in this podcast pose a very substantial risk of serious injury or death.Products and techniques discussed in this podcast are intended for use by specially trained professionals.Technical rescue, rappelling, climbing and the training involved are very hazardous activities. Each situation has its own unique conditions and must be evaluated by those present. Effective risk management comes from experience, proper training and good personal judgment.CMC is not liable for any damages arising from abuse or improper use of the techniques or equipment discussed in this podcast.Topics discussed are the ideas and opinions of each individual.Department protocol and regulations should always take precedence.

CMC Podcast
E18 - GRIMP™ North America 2022

CMC Podcast

Play Episode Listen Later Aug 18, 2021 48:04


0:08 What is GRIMP?1:43 How GRIMP North America came to be.13:33 Training for provided CMC gear.16:45 What was it like to be a participant at the first GRIMP North America?19:30 How did GRIMP change the way you operate afterwards?24:45 If given the opportunity, would you participate in the event again?25:40 What's in the works for GRIMP North America 2022?26:30 What is a GRIMP team composed of?27:15 How were teams evaluated and scored?30:35 Testing the do-ability of scenarios ahead of time.32:27 How different standards around the world factor into the event.34:45 Scope of new and/or different equipment and techniques within the event.42:40 What's in the works for GRIMP North America 2022 scheduled for March 24-26 Links:https://www.cmcpro.com/grimp-na/https://www.pacificbattleship.com/ Important WarningMany of the activities discussed in this podcast pose a very substantial risk of serious injury or death.Products and techniques discussed in this podcast are intended for use by specially trained professionals.Technical rescue, rappelling, climbing and the training involved are very hazardous activities. Each situation has its own unique conditions and must be evaluated by those present. Effective risk management comes from experience, proper training and good personal judgment.CMC is not liable for any damages arising from abuse or improper use of the techniques or equipment discussed in this podcast.Topics discussed are the ideas and opinions of each individual.Department protocol and regulations should always take precedence.

CMC Podcast
E17 - CMC Product Design & Engineering

CMC Podcast

Play Episode Listen Later Aug 11, 2021 52:32


0:07 Introductions0:48 How does CMC decide what products to develop and focus on?5:10 What does the development process look like once you decide what products to pursue?10:18 Can you talk about the design and engineering process for the CLUTCH?14:00 The challenges that come from the variability of rope.15:00 Ware testing18:14 How did you go about the design and engineering for the ATOM harness?22:50 What was involved in brining the Outback to market?28:05 Have you had any 'ah ha' moments during the design of these products?34:18 What kind of challenges do you face when developing rescue and access equipment?37:35 What role does the CMC School play in field testing gear?46:15 What should customers expect in future product from CMC?48:50 Closing thoughts Links:13:09 CLUTCH technical data https://www.cmcpro.com/technical/CMC CLUTCH by Harken Ind https://www.cmcpro.com/c/clutch/Outback Harness https://www.cmcpro.com/equipment/outback-convertible-harness/G11 Rope https://www.cmcpro.com/equipment/cmc-g11-lifeline/Triskelion Industrial Rescue Tripod https://www.cmcpro.com/equipment/triskelion-tripod/LEVR Escape System https://www.cmcpro.com/equipment/levr-escape-system/ Important WarningMany of the activities discussed in this podcast pose a very substantial risk of serious injury or death.Products and techniques discussed in this podcast are intended for use by specially trained professionals.Technical rescue, rappelling, climbing and the training involved are very hazardous activities. Each situation has its own unique conditions and must be evaluated by those present. Effective risk management comes from experience, proper training and good personal judgment.CMC is not liable for any damages arising from abuse or improper use of the techniques or equipment discussed in this podcast.Topics discussed are the ideas and opinions of each individual.Department protocol and regulations should always take precedence.

CMC Podcast
E15 - Redundancy

CMC Podcast

Play Episode Listen Later Jun 30, 2021 40:46


Topics:0:35 How does NFPA compliant gear as well as modern gear in general change what we do, how we rig and the way we operate?1:18 Redundancy - What needs to be backed up and what doesn't? Starting with harness.3:40 Redundancy of anchors and specifically anchor points.11:00 Redundancy in anchor plates.13:30 Redundant carabiners in twin tension systems.18:35 Redundancy in edge protection.23:48 Change of direction in twin tension systems.28:10 Wrapping webbing around the top rail of the litter to back it up.30:08 Litters in helicopter rescue.Important WarningMany of the activities discussed in this podcast pose a very substantial risk of serious injury or death.Products and techniques discussed in this podcast are intended for use by specially trained professionals.Technical rescue, rappelling, climbing and the training involved are very hazardous activities. Each situation has its own unique conditions and must be evaluated by those present. Effective risk management comes from experience, proper training and good personal judgment.CMC is not liable for any damages arising from abuse or improper use of the techniques or equipment discussed in this podcast.Topics discussed are the ideas and opinions of each individual.Department protocol and regulations should always take precedence.

CMC Podcast
E14 - Are you training as you would conduct a real rescue?

CMC Podcast

Play Episode Listen Later Jun 16, 2021 45:45


1:17 Real people vs manikins?9:16 Do you know of people who still use manikins?10:24 Confined space training and realistic spaces - are you training as you would conduct a real rescue?11:58 Who do contact to get access to real spaces to training in?17:40 What is the purpose of training and what are the different goals?19:38 Are you learning a skill or doing a realistic training?22:00 Training with realistic resources and man power.24:55 Logistics of training people and the importance of repetition.26:15 Hobbyist vs practitioner.26:44 Training bias and practicing your bread and butter.31:03 How do you innovate if you're always practicing as you would conduct a real rescue?38:22 Are you prepared for possible mutual aid call scenarios in your neighboring area? Links:2:30 2004 ITRS, 'Using Live Rescuers as "Victims" in Vertical Rope Rescue Training - "Is it Safe?"' by Tom Finch https://itrsonline.org/tproduct/1-365251861291-using-live-rescuers-as-victims-in-vertic3:05 2011 ITRS, 'Study of the Perceived Benefits & Liabilities of Use of Manikins vs. Live Patients in Rescue Training' by Russel McCullar https://itrsonline.org/tproduct/1-966765737441-study-of-the-perceived-benefits-amp-liab Important WarningMany of the activities discussed in this podcast pose a very substantial risk of serious injury or death.Products and techniques discussed in this podcast are intended for use by specially trained professionals.Technical rescue, rappelling, climbing and the training involved are very hazardous activities. Each situation has its own unique conditions and must be evaluated by those present. Effective risk management comes from experience, proper training and good personal judgment.CMC is not liable for any damages arising from abuse or improper use of the techniques or equipment discussed in this podcast.Topics discussed are the ideas and opinions of each individual.Department protocol and regulations should always take precedence.

CMC Podcast
E13 - Backcountry Rescue

CMC Podcast

Play Episode Listen Later Jun 2, 2021 56:50


Topics1:46 What would you say makes a rescue 'backcountry' as opposed to something else?6:02 Volunteer retention in SAR?13:40 Easy in, easy out.17:50 MRA competency.22:32 Maintaining competency and standards.27:00 How do you test competency? How do you design tests so that people aren't just training to pass the test.30:55 Who supplies medical support for the wilderness teams?36:29 Search44:16 Do you have two sets of gear? LinksCraig McClure: https://www.roninrescue.com/ Important WarningMany of the activities discussed in this podcast pose a very substantial risk of serious injury or death.Products and techniques discussed in this podcast are intended for use by specially trained professionals.Technical rescue, rappelling, climbing and the training involved are very hazardous activities. Each situation has its own unique conditions and must be evaluated by those present. Effective risk management comes from experience, proper training and good personal judgment.CMC is not liable for any damages arising from abuse or improper use of the techniques or equipment discussed in this podcast.Topics discussed are the ideas and opinions of each individual.Department protocol and regulations should always take precedence.

CMC Podcast
E12 - Fire Escape Bailout Systems

CMC Podcast

Play Episode Listen Later May 19, 2021 93:41


3:39 Dale, what was your first exposure to bailout systems?9:35 When you started off making procedures and figuring out how to do bailout in the 90's, was it mostly trial and error?15:43 LeRoy, What was your first exposure to bailout?19:42 Dale, do you remember your first solid bailout kit?21:48 Dale, are you an escape belt guy or a harness in the pants guy?24:14 LeRoy, were you a an escape belt guy or a harness in the pants guy when you were in the fire department?27:28 Do you think there's a negative connotation with the term 'bailout kit'?33:45 Forward deployed RIT teams.38:01 The hook of the system rated as an emergency decent control device.58:00 Fall protection harnesses for training.110:03 Anchoring and running the rope or web around edges and corners to reduce force on the anchor.116:58 What is the future of escape systems? Links & Resources0:58 Dale's YouTube Channel: https://www.youtube.com/c/DALEGPEKEL/videos2:16 / 12:55 Bailout wall prop. Reach out to Dale Pekel directly for his bailout wall prop at FFDPEK@aol.com YouTube video : https://youtu.be/xMfbeaGBO-A10:35 https://www.firechief.com/ & https://www.firefighterclosecalls.com/18:16 / 105:07 Kelly Byrne, 2010 ITRS Defenestration Sensation Presentation: https://itrsonline.org/tproduct/1-840977196521-the-defenestration-sensation18:50 London Fire Brigade training article from 1876: https://archive.org/details/fireprotectiona00shawgoog/page/n292/mode/2up?ref=ol&view=theater51:40 Window Clearing, Anchoring and Exit Techniques: https://youtu.be/0K38As-hS7I58:30 Dale's Improvised webbing harness YouTube video https://youtu.be/r7OoDhfDo6U105:20 Mike Forbes & Matt Hunt, 2016 ITRS The Impact of Extreme Fire Behavior on Firefighter Escape Systems https://itrsonline.org/tproduct/1-343920467761-the-impact-of-extreme-fire-behavior-on-f106:10 2017 Ole Kills & John McKently, Is My Escape Line Still Safe After ... ? An Investigation into the Fatigue Strength of Aramid Fibers in Escape Applications: https://itrsonline.org/tproduct/1-904616887791-is-my-escape-line-still-safe-after-an-in113:50 Dale's Tool in the Wall Technique YouTube video: https://youtu.be/0K38As-hS7I Important WarningMany of the activities discussed in this podcast pose a very substantial risk of serious injury or death.Products and techniques discussed in this podcast are intended for use by specially trained professionals.Technical rescue, rappelling, climbing and the training involved are very hazardous activities. Each situation has its own unique conditions and must be evaluated by those present. Effective risk management comes from experience, proper training and good personal judgment.CMC is not liable for any damages arising from abuse or improper use of the techniques or equipment discussed in this podcast.Topics discussed are the ideas and opinions of each individual.Department protocol and regulations should always take precedence.

CMC Podcast
E11 - AZ Vortex (Part II of II) What does independent anchoring of the feet actually mean?

CMC Podcast

Play Episode Listen Later May 5, 2021 35:50


Join the ConversationPlease email us with questions or comments about this topic at podcast@cmcpro.com Important Warning:Many of the activities discussed in this podcast pose a very substantial risk of serious injury or death.Products and techniques discussed in this podcast are intended for use by specially trained professionals.Technical rescue, rappelling, climbing and the training involved are very hazardous activities. Each situation has its own unique conditions and must be evaluated by those present. Effective risk management comes from experience, proper training and good personal judgment.CMC is not liable for any damages arising from abuse or improper use of the techniques or equipment discussed in this podcast.Topics discussed are the ideas and opinions of each individual.Department protocol and regulations should always take precedence.

CMC Podcast
E10 - AZ Vortex (Part I of II) Belay High, Low or Through an AZTEK?

CMC Podcast

Play Episode Listen Later Apr 28, 2021 53:28


Links4:00 YouTube Video - Vortex drop 2012  Paper - 2007 ITRS Presentation on Belay Line Tests with Vortex "Again.....Are you REALLY on Belay" (part 2)  -  Reed Thorne from Ropes that Rescue6:20 YouTube Video: Rope Rescue Systems Testing - Main/Belay (Back-up) FailuresKirk Mauthner Sharp Edge Testing in - EMBC Rope Rescue NIF Equipment Testing Summary Report 2016 (cmd + f and search 'sharp edge') 13:43 YouTube Video - How Far Will You Fall? - Tom Pendley 45:40 CMC Rope Rescue Manual Join the ConversationPlease email us with questions or comments about this topic at podcast@cmcpro.com Important Warning:Many of the activities discussed in this podcast pose a very substantial risk of serious injury or death.Products and techniques discussed in this podcast are intended for use by specially trained professionals.Technical rescue, rappelling, climbing and the training involved are very hazardous activities. Each situation has its own unique conditions and must be evaluated by those present. Effective risk management comes from experience, proper training and good personal judgment.CMC is not liable for any damages arising from abuse or improper use of the techniques or equipment discussed in this podcast.Topics discussed are the ideas and opinions of each individual.Department protocol and regulations should always take precedence.

CMC Podcast
E9 - Myths in Rope Rescue (Part III of III)

CMC Podcast

Play Episode Listen Later Apr 21, 2021 53:34


1:18 There's no difference between NFPA and non-NFPA rated gear.10:05 What are some of the portions of NFPA testing and inspecting?17:25 Clarifying semantics of NFPA 'certified' vs 'classified' or 'compliant'.25:24 What is the evolution of the testing process?28:47 What gear is exempt from being NFPA compliant?30:17 Evolution of the standards over time.30:53 What impact should using NFPA gear have on the way we use the gear? Links:NFPA 1983 Standards: https://nfpa.org/codes-and-standards/all-codes-and-standards/list-of-codes-and-standards/detail?code=198315:20 False Economy: https://en.wikipedia.org/wiki/False_economy Join the ConversationPlease email us with questions or comments about this topic at podcast@cmcpro.com Important Warning:Many of the activities discussed in this podcast pose a very substantial risk of serious injury or death.Products and techniques discussed in this podcast are intended for use by specially trained professionals.Technical rescue, rappelling, climbing and the training involved are very hazardous activities. Each situation has its own unique conditions and must be evaluated by those present. Effective risk management comes from experience, proper training and good personal judgment.CMC is not liable for any damages arising from abuse or improper use of the techniques or equipment discussed in this podcast.Topics discussed are the ideas and opinions of each individual.Department protocol and regulations should always take precedence. 

CMC Podcast
E8 - Myths in Rope Rescue (Part II of III)

CMC Podcast

Play Episode Listen Later Apr 14, 2021 48:20


0:50 Myth 1: NFPA requires steel carabiners for use.4:15 Myth 2: If you drop aluminum hardware it will develop microscopic cracks.10:13 What do we do about the fire departments that say we have to use steel carabiners? How do we educate them that there's other ways to go?15:57 Myth 3: We have to use G rated gear.18:22 Myth 4: Your belay line has to be hooked up to your dorsal connection on your class III harness.24:50 What do you tell people that are under the impression you have to wear a class III harness for rope rescue?29:22 Myth 5: You can't use T rated gear on a rescue.30:18 Myth 6: It's got to be a 15:1 safety factor, NFPA says so.31:50 In NFPA 1983 now, what is a G rating for a descent control device?47:00 Is there a difference between NFPA and non-NFPA gear? Links:NFPA 1983 Standards: https://nfpa.org/codes-and-standards/all-codes-and-standards/list-of-codes-and-standards/detail?code=198320:05 Chiclets: https://en.wikipedia.org/wiki/Chiclets Join the ConversationPlease email us with questions or comments about this topic at podcast@cmcpro.com Important Warning:Many of the activities discussed in this podcast pose a very substantial risk of serious injury or death.Products and techniques discussed in this podcast are intended for use by specially trained professionals.Technical rescue, rappelling, climbing and the training involved are very hazardous activities. Each situation has its own unique conditions and must be evaluated by those present. Effective risk management comes from experience, proper training and good personal judgment.CMC is not liable for any damages arising from abuse or improper use of the techniques or equipment discussed in this podcast.Topics discussed are the ideas and opinions of each individual.Department protocol and regulations should always take precedence.

CMC Podcast
E7 - Myths in Rope Rescue (Part I of III)

CMC Podcast

Play Episode Listen Later Apr 7, 2021 46:01


2:12 Myth 1: When you have a screw gate carabiner in the vertical axis you must always have it so the gate opening is at the bottom.5:30 Myth 2: When you have two carabiners connected to the same thing the gates need to be opposite and opposed.11:00 Myth 3: How you load webbing into an offset D carabiner.15:18 Myth 4: No metal on metal.21:58 Myth 5: Stay with dedicated main and dedicated belay and don't use TTRS because of edge transitions.39:30 If something doesn't make sense, is 'why' a bad question to ask?Links:22:28 Mike Gibbs and Kevin Koprek - Two Tension or not to Tension: https://riggingforrescue.com/wp-content/uploads/2019/03/Two-Tension-or-Not-to-Tension.pdf22:28 2015 ITRS Mike Gibbs - Mirrored Systems: http://itrsonline.org/wordpress/wp-content/uploads/2015/11/ITRS-2015-Gibbs-Paper-Final.pdf

Freelance Blend Podcast
How Freelancers Can File Their Annual ITRs with Taxumo (FBP 195)

Freelance Blend Podcast

Play Episode Listen Later Apr 6, 2021 50:55


It’s tax season once again, and if you’re a freelancer, business owner or even an employee earning from freelance gigs, you may be wondering: “How do I file my Annual Income Tax Return (ITR) with the BIR?” I actually have the same question, especially since I became an employee again last year (while at the […] The post How Freelancers Can File Their Annual ITRs with Taxumo (FBP 195) appeared first on Freelance Blend.

file freelancers bir itrs freelance blend
CMC Podcast
E6 - Interview with John McKently - 47 Years of SAR

CMC Podcast

Play Episode Listen Later Mar 31, 2021 53:59


Topics:1:00 Who is John McKently?2:05 What do you see as the biggest changes that have taken place over your career?4:45 Carabiner types and material evolution.7:40 What did you do before CMC?8:45 How did you get into rescue originally?10:00 How many rescues over the years?11:50 Changes in systems and hardware.18:40 Camp crews and labor management.20:55 Other equipment changes over the years.24:17 Standards27:55 How do resources like helicopters interface with your typical responses?33:05 Where do you think things in rope rescue are going?39:08 Decent control numbers.51:05 Closing thoughts.Links:2:30 Kernmantal Rope https://en.wikipedia.org/wiki/Kernmantle_rope2:30 Laid Rope https://en.wikipedia.org/wiki/Rope#Laid_or_twisted_rope Additional LinksPlymouth Cordage Company https://www.plymouthcordageco.org/

CMC Podcast
E5 - Are bowlines Safe Enough for Rope Rescue?

CMC Podcast

Play Episode Listen Later Mar 24, 2021 42:29


Topics:0:20 Are bowlines safe enough for rope rescue?4:00 What makes a rescue knot a good knot?7:30 What testing has been done and how strong are bowlines?12:35 How do you define a bowline?14:30 Is there a standard test for knots for cyclic loading?16:40 Difference between a climbing knot and a rope rescue knot?17:15 Anecdotal story of a bowline on a coil slipping without a safety knot.19:17 Safety knots.24:40 Organizational alignment.26:50 Standardized and reproducible testing.34:40 Mis-tied bowlines.35:40 Why do we call it a bowline on a coil?Links:1:11 Kelly Byrne, ITRS 2019, Boutique Bowlines http://itrsonline.org/wordpress/wp-content/uploads/2019/10/Byrne_Boutique-Bowlines.2019.pdf12:40 Mark Gommers, Analysis of Bowlines http://www.paci.com.au/downloads_public/knots/Bowlines_Analysis.pdf Password: copyright13:30 International Guild of Knot Tyers IGKT https://www.igkt.net/37:15 Ashley's Book of Knots https://www.google.com/books/edition/The_Ashley_Book_of_Knots/QaSBVuPK9H0C?hl=en&gbpv=0 

CMC Podcast
E4 - Is the Belay Competency Drop Test Still Valid?

CMC Podcast

Play Episode Listen Later Mar 17, 2021 48:53


Topics:What is the Belay Competency Drop Test?Brief history of past papers and arguments discussing the topic.How do you have a good test to test something where you have to let go of it to make it work?Is there a way to account for the human element?Is there a better test?If one line fails, is it still controllable?Where do you want your best guy?What is the safest belay system?When was the last time there was a main line failure during a real operation as opposed to training?Links:1:05 ASTM F2436 - 14(2019) https://www.astm.org/Standards/F2436.htm4:05 John Dill, 1991, Are You Really on Belay?, Part 1 (from Response Magazine, Summer 1991) https://caves.org/section/vertical/nhback/NH32.pdf4:05 John Dill, 1991, Again.....Are you REALLY on Belay, Part 2 (from Response Magazine, Fall 1991) http://itrsonline.org/wordpress/wp-content/uploads/2015/03/OnBelay.Thorne.20071.pdfRussel McCullar, An Analysis of the Modern‐Day Belay: Competent Belay or Competent Belayer? http://itrsonline.org/wordpress/wp-content/uploads/2017/12/McCullar-Belay-ITRS-2017-Revised_12.pdf13:10 Kelly Byrne blog discussing not letting go: http://rescue2training.com/?p=135516:40 Link to future episode 'Belay High, Low or through and AZTEK on AZV'22:45 Kirk Mauthner, ITRS 2014 Moving Beyond 10:1 SSSF http://itrsonline.org/wordpress/wp-content/uploads/2015/02/008.Mauthner.2014.pdfKirk Mauthner, ITRS 2016 Dual Capability Two Tensioned Rope Systems (DC TTRS) http://itrsonline.org/wordpress/wp-content/uploads/2016/11/Mauthner-Presentation-ITRS-2016-v2.pdf22:55 Mike Gibbs & Kevin Koprek, ITRS 2019 Two Tension or Not to Tension, http://itrsonline.org/wordpress/wp-content/uploads/2019/11/Two-Tension-or-Not-to-Tension_Koprek_2019.pdf23:00/23:36 Russ McCullar ITRS 2017 An Analysis of the Modern‐Day Belay: Competent Belay or Competent Belayer? http://itrsonline.org/wordpress/wp-content/uploads/2017/12/McCullar-Belay-ITRS-2017-Revised_12.pdf23:00 Russ McCullar ITRS 2015 An Analysis of Traditional Un-tensioned Belays and Two-tensioned Rope Systems in Rope Rescue http://itrsonline.org/wordpress/wp-content/uploads/2015/11/McCullar_Analysis-of-Traditional-and-Two-tensioned-Rope-Systems.pdf23:10 Tom Pendley ITRS 2017 Slow Pull Testing of 8 mm Prusik Loops in Basket Hitch and Girth Hitch Configurations http://itrsonline.org/wordpress/wp-content/uploads/2019/11/2017_Analysis-of-8mm-prusik-loops_Pendley.pdf23:15 Tom Pendley ITRS 2018 Belay performance testing with a Petzl ASAP Lock at the anchor http://itrsonline.org/wordpress/wp-content/uploads/2019/01/Pendley_Petzl-ASAP-Belay-Testing.pdf23:15 Tom Pendley ITRS 2017 Slow Pull Testing of Track Line Tensioning Systems Used in High Line Systems. http://itrsonline.org/wordpress/wp-content/uploads/2017/11/2017_High-line-force_Pendley.pdf 33:10 Kirk Mauthner, 2016, EMBC Rope Rescue NIF Equipment Testing Summary Report https://members.bcsara.com/wp-content/uploads/2017/04/EMBC-Rope-NIF-Basecamp-Testing-Results.pdf Additional Links:DRR Rescue 2012 AZ Vortex Drop Testing Video: https://www.youtube.com/watch?v=PEyUnEEwdLI&feature=youtu.beSAR3 List of Belay Testing: http://sarrr.weebly.com/belays.html 

CMC Podcast
E3 - Should aerial ladders be used as artificial high directionals for rope rescue?

CMC Podcast

Play Episode Listen Later Mar 10, 2021 43:03


TopicsShould aerial ladders be used as artificial high directionals for rope rescue?Examples of when you might use an aerial ladder as an artificial high directional.Minimize the load, maximize the degree of aerial elevation, minimize aerial extension, keep the ropes distinct resultant and distinct with crane theoryWhat other rope rescue scenario is a go, no go by a 300lb margin?Attendant or no attendant?Aerial ladder constructionHow do we account for the belay impact on the ladder?Are aerial ladders bombproof?Block and Tackle theoryDo your researchJoin the ConversationPlease email us with questions or comments about this topic at podcast@cmcpro.comLinksMike Forbes' website: www.RopeCraft.orgITRA (International Technical Rescue Association) https://itra.international/2:50 Pat Rhodes - Aerial Ladders Used as Artificial High Directionals (AHD) https://www.youtube.com/watch?v=QOep0xKQY6Q14:20 Kelly Byrne's 1016 paper at ITRS on 'Fire Department High Directionals' http://itrsonline.org/fire-department-high-directionals-in-urban-environments/35:10 National Fire Academy paper https://www.usfa.fema.gov/downloads/pdf/publications/tr-081.pdfAdditional Resources: Aerial Physics http://www.lacountyfirefighters.org/images/shared/Apparatus_Operator/KME_Aerial_Manual/BSUB3_LACFFASSOC_2010_KME_AerialCat_Manual_Aerial_Physics.pdf Important Warning:Many of the activities discussed in this podcast pose a very substantial risk of serious injury or death.Products and techniques discussed in this podcast are intended for use by specially trained professionals.Technical rescue, rappelling, climbing and the training involved are very hazardous activities. Each situation has its own unique conditions and must be evaluated by those present. Effective risk management comes from experience, proper training and good personal judgment.CMC is not liable for any damages arising from abuse or improper use of the techniques or equipment discussed in this podcast.Topics discussed are the ideas and opinions of each individual.Department protocol and regulations should always take precedence. 

BusinessLine Podcasts
Jargon Busters | Tax Fundas: Episode 3 - ITRs and due dates

BusinessLine Podcasts

Play Episode Listen Later Oct 27, 2020 5:01


Recently, the Government has extended the due date of filing our income tax returns. How crucial are these due dates? What happens if you don't make the payments on time? BusinessLine's Research Analyst Satya Sontanam tells us more on these lines. Listen to the podcast. --- Send in a voice message: https://anchor.fm/business-line/message

Waters Wavelength
Episode 194: ITRS Group’s Warren on Capacity Planning

Waters Wavelength

Play Episode Listen Later May 7, 2020 48:46


This week, Guy Warren, CEO of ITRS Group, joins Wei-Shen on the podcast. They discuss the importance of capacity planning and some of the capacity issues clients have been facing as a result of higher volatility. He also sheds light on what the future will look like for application development in a crowded market.  3:00 - Off the recent earnings season, Wei-Shen and Tony discuss how the likes of Morgan Stanley, BlackRock, and StateStreet are now portraying themselves more as technology companies.  https://www.waterstechnology.com/technology/7531841/morgan-stanleys-katherine-wetmur-on-the-banks-tech-investment-covid-19-response https://www.waterstechnology.com/operations/7538871/blackrock-onboards-8-aladdin-clients-remotely 14:30 - Guy joins the podcast, and gives an overview of ITRS Group and capacity planning as a whole.   18:40 - He talks about the acquisition of Sumerian in 2018 and previous thoughts of building a capacity planning tool  https://www.waterstechnology.com/organization-management/alliances-mergers-acquisitions/3669186/itrs-buys-capacity-management-firm-sumerian 23:30 – Then, they talk about the capacity challenges firms are facing at this time. He says that most companies are unaware their systems have a throughput limit.   27:30 – Guy explains how capacity thresholds are set, monitored, and at what point ITRS alerts their customers.    30:00 - How are capacity challenges addressed? Guy discusses elastic applications.   33:00 - What does the future look like for application development? What happens with existing applications?   35:30 - He talks about the ITRS capacity planner and how take-up has been as a result of Covid-19. Guy explains how people want to “Try before they buy.”   37:00 - Where have investment firms found their infrastructure inadequate to meet current trading volumes and demands?  40:00 - What are some new features ITRS is working on for the tool? Guy wraps up talking about cloud cost optimization.

Ronin RescueCast
PodCast 32 CrakerJack ASAP Testing - 2019 - 11 - 21, 1.46 PM

Ronin RescueCast

Play Episode Listen Later Nov 21, 2019 36:18


An interview with Craig McClure regarding testing of the ASAP use in a highline system. The CrackerJack Group and Ronin Rescue conducted this testing and it was presented by Craig at ITRS 2019.

testing itrs craig mcclure
Ronin RescueCast
RescueCast 30 - Answers To Listeners Questions

Ronin RescueCast

Play Episode Listen Later Oct 12, 2019 46:07


This RescueCast answers questions listeners have sent in about gear, ITRA, ITRS and a Flemish Reeve. If you have any more questions, please feel free to send them to us

Regenerative Medicine and Gene Therapy
E. Ayuso - Unraveling mechanisms and biology of recombinant AAV vectors produced in insect cells

Regenerative Medicine and Gene Therapy

Play Episode Listen Later Dec 2, 2016 59:54


Eduard Ayuso, INSERM 1089, University of Nantes, Nantes, France speaks on "Unraveling mechanisms and biology of recombinant AAV vectors produced in insect cells". Recombinant adeno-associated vectors (rAAV) are viral vectors of choice for gene therapy of many inherited diseases. Medicinal products based on rAAV are predominantly manufactured by transient transfection of mammalian cells or baculovirus expressing vectors (BEV) infection of insect cells, being the latter method more suitable for large-scale production. Although AAVs are mammalian viruses they can be assembled in insect cells, but the biology of the system has been poorly investigated. Here, we have studied the role of the assembly-activating protein (AAP) in insect cells and we found that this protein is expressed in a similar manner as in mammalian cells. By knocking down the AAP, it was confirmed that AAP is required for the assembly of AAV2 particles in insect cells. Next, we aimed to identify and characterize DNA species encapsidated in rAAV stocks produced in insect cells. To this end, we developed a single-strand virus sequencing protocol based on Illumina high-throughput sequencing technology (HTS). Preliminary data obtained from rAAV stocks puri ed by CsCl ultracentrifugation or immunoaffnity chromatography revealed that baculoviral and cellular DNA correspond to ≤1.5% and ≤0.02% of the total reads, respectively. Moreover, the sequencing coverage showed that the proximity to the ITRs increases progressively the probability for baculoviral DNA to be encapsidated. Nonetheless, these baculovirus-derived reads are found at a frequency of 2-3 logs lower than the rAAV genome reads. The development of accurate quality control methods is not only critical for fulfilling regulatory requirements, but will also provide novel insights into the biological mechanism of rAAV assembly in insect cells. This movie has been recorded by ICGEB Trieste.

Fakultät für Biologie - Digitale Hochschulschriften der LMU - Teil 05/06
Molecular cytogenetics and phylogenetic modeling to study chromosome evolution in the araceae and sex chromosomes in the cucurbitaceae

Fakultät für Biologie - Digitale Hochschulschriften der LMU - Teil 05/06

Play Episode Listen Later Jun 4, 2014


This study involved the combination of molecular-cytogenetic data and phylogenetic approaches to infer pathways by which chromosome numbers and sizes may have changed during the course of evolution. The two systems for which I generated new data are the monocot plant family Araceae and Coccinia, a genus of Cucurbitaceae. Araceae have about 3800 species in 118 genera, and chromosome numbers range from 2n = 168 to 2n = 8, the latter the lowest number so far and newly reported in my study. The small genus Coccinia includes C. grandis, with the largest known Y chromosome in plants, as documented in my work. The thesis comprises four published or submitted papers. The first paper reports the result of phylogenetic modeling of chromosome number change along a phylogeny for the Araceae with 113 genera represented. I used a maximum likelihood approach to find the most likely combination of events explaining today’s chromosome numbers in the 113 genera. The permitted events were chromosome gains (i.e. breaks), losses (i.e. fusions), doubling (polyploidization), or fusion of gametes with different ploidy. The best-fitting model inferred an ancestral haploid number of 16 or 18, higher than previously suggested numbers, a large role for chromosome fusion, and a limited role of polyploidization. The sparse taxon sampling and deep age (at least 120 Ma) of the events near the root of Araceae caution against placing too much weight on “ancestral” numbers, but inferred events in more closely related species can be tested with cytogenetic methods, which I did in two further studies (papers 2 and 3). I selected Typhonium, with 50-60 species, a range of 2n = 8 to 2n = 65 chromosomes. The family-wide study had suggested a reduction from a = 14 to 13 by fusion in Typhonium, but had included relatively few of its species. I built a phylogeny that included 96 species and subspecies sequenced for a nuclear and two chloroplast markers, and then selected 10 species with 2n = 8 to 24 on which to perform fluorescence in situ hybridization (FISH) with three chromosomal probes (5S rDNA, 45S rDNA, and Arabidopsis-like telomeres; paper 2). The results supported chromosome fusion in two species where I found interstitially located telomere repeats (ITRs), which can be a signal of end-to-end fusions, and polyploidization in one species where I found multiple rDNA sites. I then extended my cytological work to other lineages of Araceae, selecting 14 species from 11 genera in key positions in the family phylogeny, which I enlarged to 174 species, adding new chromosome counts and FISH data for 14 species with 2n = 14 to 2n = 60 (paper 3). With the new data, I confirmed descending dysploidy as common in the Araceae, and I found no correlation between the number of rDNA sites and ploidy level (which would have pointed to recent polyploidy). I detected ITRs in three further species, all with 2n = 30. I also discovered gymnosperms-like massive repeat amplification in Anthurium. Similar ITRs are only known from Pinus species. Paper 4 presents molecular-cytogenetic data for Coccinia grandis, one of a handful of angiosperms with heteromorphic sex chromosomes. The male/female C-value difference in this species is 0.09 pg or 10% of the total genome. My FISH and GISH results revealed that the Y chromosome is heterochromatic, similar to the Y chromosomes of Rumex acetosa, but different from the euchromatic Y chromosome of Silene latifolia; it is more than 2x larger than the largest other chromosome in the genome, making C. grandis an ideal system for sequencing and studying the molecular steps of sex chromosome differentiation in plants.

Fakultät für Chemie und Pharmazie - Digitale Hochschulschriften der LMU - Teil 04/06
Analysis of Adenovirus-Host Interactions to Improve Recombinant Adenoviral Vectors for Gene Therapy

Fakultät für Chemie und Pharmazie - Digitale Hochschulschriften der LMU - Teil 04/06

Play Episode Listen Later Mar 3, 2011


Recombinant adenoviral vectors are among the most commonly used vehicles in gene therapy. Replication-deficient adenoviruses include early generation adenoviruses, which are deleted in less than three adenoviral genes, and the high-capacity adenoviruses (HC-AdV) as the most advanced form. HC-AdVs are deleted for all viral sequences leaving only the two inverted terminal repeat sequences (ITRs) and the packaging signal from the original viral genome. Therefore, up to 36 kilobases of foreign DNA can be packaged by HC-AdV particles and transduced into the desired target cell. Efficacy of these vectors was shown in several animal models, in which a single injected virus dose resulted in up to 3 years of transgene expression. However, also for recombinant adenoviruses including HC-AdVs limiting factors remain, which were investigated and improved in the course of this work. The production of HC-AdV represents one limiting factor because it is a labour intensive and sophisticated process that requires some experience. Therefore, in this study, a protocol was developed that simplifies the generation of these viruses starting with an improved cloning procedure and ending with precise titration of the purified particles. In addition, this improved virus production procedure was used to demonstrate the feasibility of HC-AdV to delivery short-hairpin RNAs, thus reducing hepatitis B RNA molecules in vitro and in vivo. The majority of HC-AdVs are currently based on the adenovirus serotype 5 (Ad5). However, DNA sequences inserted into the HC-AdV genome and remaining viral sequences were shown to influence duration and stability of transgene expression, which can negatively influence the outcome of a therapeutic approach. By analyzing viral ITR sequences derived from different adenoviral serotypes, this work demonstrated that ITR-driven transcriptional activity from several serotypes but also inhibiting functions occur leading to reduced transgene expression. Furthermore, a negative impact of ITR sequences on nearby promoters could be observed. The data obtained in this work suggest that it could be beneficial to introduce shielding sequences into the HC-AdV genome, which flank the transgene expression cassettes and therefore, prevent undesired side effects. Moreover, the results indicated, that pursuing ITRs from adenovirus serotype 7 in the context of an adenoviral vector could be advantageous, as it demonstrated most suitable features regarding transcriptional activation and influence on promoter performance. The efficiency of HC-AdV in terms of long-term expression of foreign DNA sequences is mainly based on the stability of vector genomes in quiescent cells. In dividing cells, however, a continuous reduction of the viral DNA reduces the therapeutic effect. Thus, integration systems on the basis of viral hybrid vectors were developed, which result into recombinase-mediated somatic integration of the therapeutic DNA from the HC-AdV genome into the chromosomal DNA. The most prominent representative of non-viral integration systems is the Sleeping Beauty (SB) transposase. Although function and efficacy of this transposase was shown in the context of an HC-AdV, it turned out, that transgene expression is decreased after Sleeping Beauty mediated transposition. Herein, analysis of transposition in cells with suppressed RNA interference pathway, showed a higher transposition rate in RNA interference knockdown cells compared to control cells, which was mainly based on an increased transgene expression. Therefore, this work shows for the first time that due to convergent transcription, originated from the two SB recognition sequences (IRs) flanking the transposon, formation of double-stranded RNAs (dsRNAs) can occur. These dsRNAs can be substrates for the RNAi mechanism and contribute to the silencing of gene expression. In the future this finding can be used to significantly improve the SB transposon technology. Moreover the influence of the RNAi mechanism on the adenovirus life cycle could be demonstrated within this project. By the suppression of the RNAi pathway using an RNAi suppressor protein we could improve recombinant adenovirus replication and viral particle production, up to 100-fold. In addition, this RNAi suppressor protein increased production of HC-AdV up to 6-fold. This upregulation was mainly based on the increased expression of viral regulatory proteins as well as the suppression of small adenoviral RNAs. In conclusion, this work provides different strategies to improve HC-AdVs for gene therapeutic purposes. Furthermore, it investigated mechanisms that negatively interfere with the therapeutic outcome, which need to be considered in future work. In particular, the influence of the RNA interference pathway on the replication profile of recombinant adenoviruses could be demonstrated for the first time essentially broadening the potential of these vectors with respect to viral production and design of oncolytic adenoviruses. In summary, this study emphasizes the importance of understanding the biology of viral vectors systems, which then can be translated into the development of optimized vectors for gene therapeutic applications.