Podcasts about ladders

Highlights of what's new in streaming for the week of May 10, 2025. Hulu The Secret Lives of Mormon Wives, season 2 (May 15) Matteo Lane: The Al Dente Special (May 16) Welcome to Wrexham, Season 4 (May 16) Netflix Tastefully Yours, season 1 (May 12) Bad Thoughts, season 1 (May 13) Untold: The Liver King (May 13) Welcome, Now Get Lost, season 1 (May 13) American Manhunt: Osama Bin Laden (May 14) Fred and Rose West: A British Horror Story (May 14) Married at First Sight, season 17 (May 14) Rhythm+Flow: Poland (May 14) Snakes and Ladders, season 1 (May 14) Bet, season 1 (May 15) Franklin, season 1 (May 15) Love, Death & Robots, Vol. 4 (May 15) Paddington in Peru (May 15) Secrets We Keep (May 15) Thank You, Next, season 2 (May 15) Vini Jr. (May 15) Dear Hongrang, season 1 (May 16) Football Parents, season 1 (May 16) The Quilters (May 16) Rotten Legacy, season 1 (May 16) Max Duster, season 1 (May 15) The Brutalist (May 16) Peacock Eurovision Song Contest (May 13 - 17) Prime Video Lee Soo Man: The King of K-Pop (May 13) Overcompensating, season 1 (May 15) Apple TV+ Murderbot, season 1 (May 16) Deaf President Now! (May 16) Tubi Rhythm and Blood (May 16)

How does a snake climb a pole? It's not like they have a ladder... or arms.It turns out that snakes have some pretty crazy skills when it comes to climbing anything and everything.The Island of Guam had between two and four million brown tree snakes in the 1980s, leading to all sorts of issues for the birds and the environment.Guests:Dr Aaron Collins- Assistant State Director Guam/Western Pacific Theatre at USDA-APHIS-Wildlife ServicesProfessor Kristin Y. Pettersen- Centre for Autonomous Marine Operations and System at the Norwegian University of Science and Technology (NTNU)Stuart McKenzie - Director/Owner at The Snake Catcher Sunshine CoastProfessor Bruce C. Jayne- Department of Biological Sciences at the University of Cincinnati.Charlie and Olivia, Board game players.Production:Ann Jones, Presenter / Producer.Petria Ladgrove, Producer.Joel Werner, Script Editing.Additional mastering:  Hamish Camilleri.This episode of What the Duck?! was originally broadcast on the 5th of March 2022 and was produced on the land of the Wadawarrung and the Kaurna people. 

Send us a textIn this episode of the Amazing Teams podcast, we sat down with Marc Cenedella, CEO of The Ladders,  to explore the evolving landscape of work culture. We discuss the shift to remote work, the key drivers of productivity, and the power of gratitude in the workplace. Marc shares insights on standing out in a competitive job market, the impact of AI on job applications, and the importance of crafting resumes that highlight measurable achievements. The conversation also touches on the role of meetings and how they can influence creativity and efficiency.We dive into:How meetings can hinder productivity and creativity.75% of job seekers prioritize intrinsic rewards over cash. Gratitude fosters a positive work environment and strengthens team cohesion. Tune in to hear Marc's advice on navigating today's job market and building a thriving career. Resources:Paul Graham's Maker's schedule, manager's scheduleLearn more about LaddersConnect with Marc on LinkedInThe Ladders Career Cab from 2011

Chatterheads, for those who have been with us since the Sunday Shenanigan days, stuck around for last season's Midweek Meltdowns... Somehow, WE'VE BEEN RENEWED FOR SEASON 3 here at Tables, Ladders, and Chatter! Tonight we bring our best analysis of the weeks following Wrestlemania 41, discuss theories leading into Backlash... And Tommy Gunns gives his "State of Wrestling" address to continue his reign as TLC Predictions Champion!Thanks To Our Sponsors:Reaper Apparel Co⁠⁠⁠⁠⁠⁠ - Reaper is not only a brand, its a complete life adjustment. A commitment to live your most authentic way every single day! Use discount code: Zero815 for 10% off your order!⁠⁠⁠⁠⁠⁠Psycho Pharma⁠⁠⁠⁠⁠⁠ - Psycho Pharma is a fast-growing company that innovates aggressive formulas to be better than most of the run of the mill products many other brands produce. All Psycho Pharma products are produced in an FDA registered manufacturing facility that follows cGMP standards, with assays on each ingredient and COA's/batch records kept for every run. Use discount code: PONYBOY815 for 20% off your order!

With WrestleMania in the rearview mirror, the Gorilla Position boys are back in the studio looking ahead to WWE Backlash from St Louis, Missouri next weekend. John Cena takes on his old nemesis Randy Orton in the main event of the show but the story to kick-start this renewed rivalry began in a very unexpected way… JD, Mekz and Kevin Clifton dissect it all. Plus, thoughts on LA Knight once again going after US gold, the first promos from Seth Rollins' new faction and their interactions with ‘main event' Sami Zayn, plus our Topps Moment of the Week powered by WWE Slam: the magnificent Tables, Ladders & Chairs match that headlined SmackDown. Download the Gorilla Position podcast NOW using the link below to get your weekly fix of all things WWE. JD and the team LOVE hearing from you so keep your emails coming in: helloyou@wwegp.co.uk Hot topics on this week's show:

In this episode, we explore the laws concerning moving different types of ladders on Shabbat, based on their use and size, as well as the rules for handling palm branches and stones designated for firewood or seating. We delve into the principles of muktzeh and when an item's status can change through thought or action before Shabbat.

Kelley discusses the importance of planning for business succession and personal legacy as one approaches retirement. She emphasizes the need for clear communication regarding succession plans, financial organization, and the significance of creating a lasting impact beyond business. The discussion also explores the evolving concept of retirement, suggesting a shift towards a more fulfilling 'thrive time' rather than traditional retirement, and highlights the importance of leisure and personal fulfillment in this new phase of life. Reach Kelley at 800-810-8060. California Wealth Advisors www.californiawealthadvisors.com See omnystudio.com/listener for privacy information.

Marty discusses the challenges and strategies for navigating market uncertainty as individuals approach retirement. He emphasizes the importance of sticking to a financial plan, understanding income-generating investments, and maximizing Social Security benefits. The discussion highlights the need for knowledge and preparation in retirement planning, particularly in light of market fluctuations and the complexities of Social Security. Reach Marty at 888-519-9096. Smart Money Solutions www.smartmoneysolutionsmn.com See omnystudio.com/listener for privacy information.

Welcome back to The Lawcast! This time our hosts cover perhaps the most legendary Wrestlemania of them all, Wrestlemania X-Seven.Of course our main event is The Rock defending the WWF Championship against "Stone Cold" Steve Austin. We disect the reasons behind Austin's heel turn and why it was such a misfire. Plus we've got Undertaker vs. Triple H, Kurt Angle vs. Chris Benoit, Vince McMahon vs. Shane McMahon, and the second Tables, Ladders, and Chairs match.We also cover Wrestlemania XLI, a disastrous week of PR for WWE, and the Raw after Wrestlemania.

You spent your career learning how to climb — but what if the ladder itself is breaking beneath you?This episode isn't about panic. It's about power.Because waiting for the system to save you is the real risk.It's time to stop trusting the climb… and start your Corporate Graduation™.***

Send us a textWrestling's greatest legends have captivated audiences for decades with their larger-than-life personas, incredible athleticism, and unforgettable storylines. As WrestleMania approaches, we're diving into our Mount Rushmore of professional wrestling – the superstars who've defined and transformed this unique form of entertainment.Our discussion spans multiple eras, from Andre the Giant's pioneering presence that changed what was possible in professional wrestling to modern-day stars like Roman Reigns, whose record-breaking championship reign has made him today's biggest attraction.Beyond ranking our favorites, we share fascinating behind-the-scenes stories about these legends – from Andre the Giant's interactions on The Princess Bride set to the dangerous Hell in a Cell match where Mick Foley was thrown from the top of the cage. We also touch on wrestling's evolution from the unregulated days of unprotected chair shots to today's more safety-conscious product.Whether you're a lifelong wrestling fan or just curious about these cultural icons, join us for this nostalgic celebration of professional wrestling's greatest characters. Check out entertainthispodcast.com to discover more episodes and connect with us on social media to share your own wrestling Mount Rushmore!Support the show

Marty talks about the recent recovery in the stock market, the implications of tariffs on American manufacturing, and the political landscape affecting economic policies. He delves into retirement planning strategies amidst market volatility, emphasizing the importance of guaranteed income streams for retirees. The discussion also touches on budgeting and managing expenses and concludes with insights on consumer confidence and the future economic outlook. Reach Marty at 888-519-9096. Smart Money Solutions www.smartmoneysolutionsmn.com See omnystudio.com/listener for privacy information.

Kelley Slaught discusses essential strategies for maintaining financial stability in retirement. She emphasizes the importance of budgeting, adjusting withdrawal strategies, and exploring additional income sources. The conversation also delves into the significance of life insurance in wealth preservation and estate planning, highlighting its evolving role. Kelley shares practical tips and insights to help listeners navigate their retirement planning effectively. Reach Kelley at 800-810-8060. California Wealth Advisors www.californiawealthadvisors.com See omnystudio.com/listener for privacy information.

Send us a textAward-winning travel journalist Lisa Niver takes us behind the scenes of her remarkable career spanning all seven continents and more than 100 countries. With warmth and candor, she reveals how a former teacher and medical school student transformed personal hardship into a life of extraordinary adventure.Lisa's journey resembles a game of "Shoots and Ladders" – unpredictable, challenging and ultimately rewarding. She shares how working at Club Med and on cruise ships opened doors to global exploration when she couldn't afford exotic trips on a teacher's salary. These experiences laid the foundation for her website We Said Go Travel, which she launched in 2010 while traveling through Asia with her then-husband.The conversation takes an emotional turn as Lisa discusses her memoir "Brave-ish: One Breakup, Six Continents and Feeling Fearless After 50." Written partly in her therapist's office, this award-winning book chronicles how travel became her path to healing and reinvention following divorce. Her vulnerability in sharing both triumphant adventures and painful struggles resonates deeply with readers seeking their own fresh start.Among Lisa's most thrilling experiences? Hula-hooping at the southernmost post office in Antarctica, completing a polar plunge in both polar regions within six months, mountain biking despite childhood trauma and paddleboarding in Antarctic waters. These adventures aren't just personal victories – they're content for her prolific output across National Geographic, Reader's Digest, television segments, podcasts and social media channels with over two million YouTube views.For media professionals, Lisa offers invaluable insights on building genuine relationships with PR teams based on mutual support rather than transactions. Her approach to content creation is equally refreshing: start small, stay consistent and remember that even the most daunting goals can be achieved "one bite at a time." Lisa's journey proves it's never too late to reinvent yourself through courage, persistence and a passport.

Les, Kurt, and Jason finally start the show on their fourth try only to immediately get sidetracked talking about Haley Joel Osment's arrest and Jason's VERY unpopular opinions about The Breakfast Club. Then Kurt reveals that he's made some progress with his quest to get Natalia Grace on the show (something Les is fully onboard with, too). In Blac Chyna news, Tokio Toni really just wants to make some beats, so she opens up her home and it doesn't end well. Then, it's time to set the table for Hallmark's Hearts Around the Table: Kiki's Fourth Ingredient, a movie which doesn't feature Edith from All and the Family or Weezie from the Jeffersons but does feature Natalie from The Facts of Life (Mindy Cohn). Have yourself a snack, whether that's Kurt's Tater Tot Casserole, some disgusting chocolate zucchini muffins, or some popcorn immediately after giving yourself a manicure.    Bluesky: lifetimeofhallmark Facebook : lifetimeofhallmark Instagram : lifetimeofhallmarkpodcast Threads: lifetimeofhallmarkpodcast TikTok: lifetimeofhallmarkpod Theme song generously donated by purple-planet.com  

In this episode we answer emails from Corn Pop, Dustin and Jim.  We discuss annuities for elderly parents, TIPS ladders in retirement, REITs in small cap value funds, currency speculation, the GDE fund (again) and an aggressive portfolio construction.Link:Interview of Michael Kitces Re Problems With TIPS Ladders:  Michael Kitces: How Higher Yields Affect Asset Allocation and Retirement Planning | MorningstarBreathless and Promotional AI-Bot Summary:Dive into the mailbag as Frank tackles complex investment questions with his signature blend of expertise and pop culture references. This episode unpacks several critical financial planning dilemmas that challenge conventional wisdom.First, Frank examines when annuities make sense for elderly parents, explaining how health prospects and longevity expectations should guide this decision. For those likely to outlive actuarial tables, annuities can provide financial value and simplify management—but they're far from universally beneficial. Frank introduces Qualified Longevity Annuity Contracts (QLACs) as a strategic option for those concerned about funding long-term care in their later years.The conversation shifts to a provocative take on TIPS ladders, with Frank describing long-term ladders as "a flex for hoarders" rather than necessary financial tools. He argues these complicated structures work best for defined periods with specific purposes—like bridging to Social Security—not as decades-long income vehicles that will inevitably be either too long or too short for your actual lifespan.Currency speculation, Bitcoin, and aggressive portfolio construction round out the episode's explorations. Frank explains how currency exposure already exists implicitly in international stocks and gold without dedicated speculation, evaluates an aggressive portfolio with substantial Bitcoin allocation, and questions whether dividend stocks belong in accumulation strategies.Throughout, Frank balances technical analysis with practical wisdom, reminding listeners that personalized investment approaches must account for individual circumstances rather than following generic advice. Whether you're managing a retirement portfolio or building wealth, you'll gain valuable perspective on how the finest investment strategies align with your actual needs rather than theoretical ideals.Want your questions answered on a future episode? Email frank@riskparityradar.com and don't forget to subscribe and leave a review!Support the show

A viewer named John emailed me the following question: "I'm planning to build a 5yr TIPS ladder to provide some inflation protected income in the years before Medicare and SS.  How do I model that "account" in Boldin??"It's a great question, and it gives us the opportunity to look at an often overlooked feature of retirement planning software--pension income. Yes, a TIPS ladder can be modeled as pension income. We'll look at it in both Boldin and ProjectionLab.Boldin: https://go.robberger.com/boldin/yt-ti...ProjectionLab: https://go.robberger.com/projectionla... (use code RBERGER-10 for a 10% discount)TIPSLadder: https://www.tipsladder.com/Join the Newsletter. It's Free:https://robberger.com/newsletter/?utm...

Send us a textWe're pulling back the curtain on what it really takes to keep the GLOW stoke alive.

Today on BnB Jake dives into his best bets for Monday's MLB slate, including his favorite home run plays of the day. Plus, Jake recaps the college baseball weekend and then answers YOUR betting questions to wrap up the show! To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices

Marty discusses the critical aspects of retirement planning, emphasizing the importance of tax strategies, the benefits of indexed universal life insurance, and the role of annuities in providing a stable income. He also explores the differences between Roth and traditional accounts, and draws parallels between retirement planning and lessons from classic literature, highlighting the need for a sound strategy in the face of current market trends. Reach Marty at 888-419-9096. Smart Money Solutions www.smartmoneysolutionsmn.com See omnystudio.com/listener for privacy information.

Kelley talks about the multifaceted challenges of retirement planning, emphasizing the importance of addressing investment risks, inflation, healthcare costs, and market volatility. She highlights the need for proactive financial planning and budgeting to avoid pitfalls such as impulse spending and credit card debt. The discussion also touches on the significance of having a comprehensive financial plan that includes estate planning and diversification of income sources. Reach Kelley at 800-810-8060. California Wealth Advisors www.californiawealthadvisors.com See omnystudio.com/listener for privacy information.

On this episode I'm joined by Trenton Woodley, the frontman for Ladders On Tables and former vocalist for Hands Like Houses.We talk about his new project Ladders On Tables, his departure from Hands Like Houses, using his new project to recreate and modernise the 'Ground Dweller' album, future plans for the project, and loads more.A new episode will be released every Thursday.-----HOW TO SUPPORT THE PODCAST:

Omar Kharbat is one of my most unique guests so far. This dude came to the US with almost nothing and worked his tail off to build multiple businesses in the service industry. After hearing his story, I realize how much so many people complain and whine rather than putting in the sweat equity to actually do something. Omar's latest venture is Boots & Ladders, a lead generation app for service providers that is disrupting the industry by fixing what Angi, Yelp, and so many others have screwed up Any kind of service provider almost. You wanna make a fulltime living replacing water heaters…done. You wanna create a side hustle using your truck to move furniture…done.   Check out Boots & Ladders at https://bootsandladders.com/.    Things mentioned in the show: Dave Ramsey- https://amzn.to/4bMPTIt  Rich Dad Poor Dad- https://amzn.to/4iyf6J9    --- Check out the sweet Hyper X mic I'm using. https://amzn.to/41AF4px    Check out Dr. Dave's Streams of Income at: www.drdavidpowers.com   www.instagram.com/drdavidpowers  www.youtube.com/@streamsofincomebydrdave  --- Join the Streams of Income community at www.facebook.com/groups/streamsofincomedream  --- Check out Passive Income Engines to find your own Streams of Income at www.SelfCoachYourself.com --- Check out my best-selling books: Rapid Skill Development 101- https://amzn.to/3J0oDJ0 Streams of Income with Ryan Reger- https://amzn.to/3SDhDHg Strangest Secret Challenge- https://amzn.to/3xiJmVO --- This page contains affiliate links. This means that if you click a link and buy one of the products on this page, I may receive a commission (at no extra cost to you!) This doesn't affect our opinions or our reviews. Everything we do is to benefit you as the reader, so all of our reviews are as honest and unbiased as possible. --- #passiveincome #sidehustle #cryptocurrency #richlife

The classic board game and one of the world's oldest religions. Link to the answer Wikipedia Thinking Music Make Believe! Support the podcasts you enjoy - lenny.fm More about the show - www.nearly.com.au/somehow-related-podcast-with-glenn-robbins-and-dave-oneil/ Somehow Related is produced by Nearly Media. Original theme music by Kit Warhurst. Artwork created by Stacy Gougoulis. Looking for another podcast? The Debrief with Dave O'Neil - Dave's other podcasts with comedians after gigs. The Junkees with Dave O'Neil & Kitty Flanagan - The sweet and salty roundabout! Junk food abounds!Support on Lenny.fm: https://www.lenny.fm/See omnystudio.com/listener for privacy information.

Send us a textGeoffrey Huber shares his journey from art school to industrial design, discussing his expertise in creating custom access and safety equipment for industries like aerospace, aviation, and manufacturing. He reveals insights into building a successful custom manufacturing business and the importance of hands-on experience in engineering.Main Topics:Transitioning from art to industrial designBuilding a custom equipment manufacturing departmentDeveloping innovative safety and access solutionsChallenges of scaling a small businessImportance of hands-on manufacturing experienceAbout the guest: Geoffrey Huber is an experienced industrial designer and entrepreneur with over 20 years of expertise in safety and access solutions. As Co-Owner and Manager of SAFE-T-FAB, he leads the design and production of innovative, code-compliant fall protection systems, ensuring rapid delivery and market leadership. He also operates GAH Enterprises LLC, a consulting firm focused on product design, prototyping, and engineering solutions. Previously, he held leadership roles at Ortho-tag, Inc. and Tri-Arc Manufacturing, Inc. Geoffrey holds a Bachelor of Science in Industrial Design from The Art Institutes and is recognized for his commitment to efficiency, innovation, and excellence in the industry.Links:Geoffrey Huber - LinkedInIndustrial Products  WebsiteSAFE-T-FAB  Website 

Chris, Danny and Ashy dissect a chaotic weekend of Premiership action. Records were broken at Ashton Gate, but are defences making it too easy? We have some breaking news regarding the Lions coaching staff and we attempt to set the scene ahead of Thursday's RFU SGM.

- Michigan State head men's basketball coach Tom Izzo discusses his relationship with Ladders, his March Madness legacy, and his relationship with Steve Mariucci. - University of Missouri head football coach Eliah Drinkwitz pitches Mizzou players Armand Membou and Luther Burden III to NFL teams and breaks down his intense caffeine routine. 

Please support the TORCH Podcasts by donating to our annual fundraiser at giveTORCH.org This is our only annual fundraiser. Every donation is DOUBLED! Support the TORCH Podcasts by visiting giveTORCH.org right now and making a generous donation! This is the LINK for the Fundraiser. – – – – – – – – – – – – – – – – […]

Please support the TORCH Podcasts by donating to our annual fundraiser at giveTORCH.orgThis is our only annual fundraiser.Every donation is DOUBLED!Support the TORCH Podcasts by visiting giveTORCH.org right now and making a generous donation!This is the LINK for the Fundraiser.– – – – – – – – – – – – – – – – – – – – – –Is the objective of Torah to constrict us or to allow us to flower? Are we ultimately supposed to curb our uniqueness, our individuality, or are we supposed to find ways to have our uniqueness sprout forth and blossom? One may argue that the Torah is very regimented in its commandments. We are told how to dress and how to eat and much of our daily schedule is compelled upon us by the myriad commandments and plethora of Divine guidances. It seems that we are being told to restrain our uniqueness and instead adopt the way of God. In this fascinating podcast, we discover that, although that is true, that is only the beginning. In the beginning of a spiritual journey, we must firm our standing as a soldier of God. However, once we are secure as a soldier, we must find a ladder to heaven. What that ladder looks like and how to find it, and how to scale its many rungs - those are the questions that we ponder in podcast.– – – – – – – – – – – – – – – – – – – – – –DONATE to TORCH: Please consider supporting the podcasts by making a donation to help fund our Jewish outreach and educational efforts at https://www.torchweb.org/support.php. Thank you!– – – – – – – – – – – – – – – – – – – – – –Email me with questions, comments, and feedback: rabbiwolbe@gmail.com– – – – – – – – – – – – – – – – – – – – – –SUBSCRIBE to my Newsletterrabbiwolbe.com/newsletter– – – – – – – – – – – – – – – – – – – – – –SUBSCRIBE to Rabbi Yaakov Wolbe's PodcastsThe Parsha PodcastThe Jewish History PodcastThe Mitzvah Podcast This Jewish LifeThe Ethics PodcastTORAH 101 ★ Support this podcast ★

Show Notes Episode 495: Avon, Amway and Tupperware, OH MY! This week host Dave Bledsoe devises a plan where he recruits two people to pay for his drinks and they recruit two people to pay for their drinks and one of his, everyone profits. (It didn't work because no one likes him enough to buy even ONE drink for him.) On the show this week we took a look back at side hustles in the 70's and 80's (And maybe by some Tupperware.) Along the way we learn that Dave might not be the worst uncle out there? Then we dive into the history of direct sales in America (Buy Farmwhoofer, buy the best!) before we head back to the beginnings of an American institution and how it made generations of American women feel pretty.  Then we move right along to the origin story of all those plastic bowls with missing lids in your parent's kitchen cabinets. (Seriously, none of these lids fit any of the bowls we have!) Then we talk about the granddaddy of multi level marketing scams. (Allegedly) And how Amway created something kind of like a cult around selling generic crap and how it is screwing us even today! Our Sponsor this week is Ponz-Co, we promise it's not illegal.  We open with the burp to seal wonder of Tupperware and close with Chutes and Ladders who are falling in love with the Avon Lady! Show Theme: Hypnostate Prelude to Common Sense The Show on Bluesky: https://bsky.app/profile/whatthehellpodcast.bsky.social The Show on Facebook: https://www.facebook.com/whatthehellpodcast/ The Show on Youtube:  https://www.youtube.com/channel/UCjxP5ywpZ-O7qu_MFkLXQUQ The Show on Instagram: https://www.instagram.com/whatthehellwereyouthinkingpod/ Our Discord Server: https://discord.gg/kHmmrjptrq Our Website: www.whatthehellpodcast.com Patreon:  https://www.patreon.com/Whatthehellpodcast The Show Line: 347 687 9601 Closer:https://soundcloud.com/chutesandladdersmusic/avon-lady?in=chutesandladdersmusic/sets/cosmetics&utm_source=clipboard&utm_medium=text&utm_campaign=social_sharing Buy Our Stuff: https://www.seltzerkings.com/shop Citations Needed: Avon's History https://www.reps-r-us.co.uk/avons-history/ Secret History Of: Tupperware https://www.independent.co.uk/property/interiors/secret-history-of-tupperware-2100910.html Social Marketing Before the Internet https://www.womenshistory.org/articles/social-marketing-internet How Does Amway Work? A comprehensive guide https://www.amway.com/en_US/amway-insider/about-amway/how-does-amway-work Inside ScAmway The alluring life offered by the world's largest 'multi-marketing' business closely resembles a sham. https://www.culteducation.com/group/815-amway/1710-inside-scamways.html Learn more about your ad choices. Visit podcastchoices.com/adchoices

If your business feels like a constant game of Chutes & Ladders—gaining momentum, only to slide right back down to square one—this episode is for you.Because listen, anyone can start a business. Anyone can build a brand. But building an intentional brand? That's what makes you unforgettable.In this episode, we're breaking down: Why checking off “business tasks” (logo, website, content) won't magically give you a strong brand—unless they're done with intention Why so many service providers feel stuck, misaligned, or like they're constantly rebuilding from scratch—and how to fix it How to uncover your true brand voice (without relying on generic “friendly and professional” BS) The difference between a business that just sells vs. a brand that builds trust, demand, and long-term loyalty Tactical steps to clarify your messaging and create a client experience that actually makes you stand out—so your audience doesn't just double-tap your posts, they book youBecause if your brand is all vibes and no depth, you're making this way harder than it needs to be. Connect with me:Instagram - @⁠pane.marketing

Send me a Text Message about the show!The broken rung: a phenomenon even more pervasive than the glass ceiling in holding women back from career success. Women around the world do extremely well when it comes to their education. They graduate at higher rates than men do and have higher average GPAs. But then a strange thing happens: Upon entering the workforce, they immediately lose their advantage. When the first promotions come around, the slide continues—for every 100 men who are promoted to manager, only 81 women get promoted. Women risk falling behind far before they are even tapping the “glass ceiling”.So, what should we do about that?  Especially in a climate where talking about diversity, equity, and inclusion has become the third rail of business development?McKinsey senior partners Kweilin Ellingrud, Lareina Yee, and María del Mar Martínez have written a new book, THE BROKEN RUNG: When the Career Ladder Breaks for Women--and How They Can Succeed in Spite of It.  The book is based on over a decade of McKinsey research, conversations with more than 50 remarkable leaders, and their own experiences as senior partners working with companies and women leaders. Buy the bookKweilin Ellingrud is McKinsey's Chief Diversity Officer and a director of the McKinsey Global Institute, based in Minneapolis. As a senior partner at McKinsey, she has led research on the topics of gender equality, racial equity, generative AI, the future of work, and global competitiveness. She also serves clients in financial services across strategy and operational transformations.Support the showKeep up with all things WeSTAT on any (or ALL) of the social feeds:Instagram: https://www.instagram.com/westatpod/Threads: https://www.threads.net/@westatpodFacebook: https://www.facebook.com/westatpod/LinkedIn: https://www.linkedin.com/company/westatpod/Twitter: https://x.com/WeSTATpodHave a topic or want to stay in touch via e-mail on all upcoming news?https://www.westatpod.com/Help monetarily support the podcast by subscribing to the show! This is an easy way to help keep the conversations going:https://www.buzzsprout.com/768062/supporters/new

Funding for the NIH and US biomedical research is imperiled at a momentous time of progress. Exemplifying this is the work of Dr. Anna Greka, a leading physician-scientist at the Broad Institute who is devoted to unlocking the mysteries of rare diseases— that cumulatively affect 30 million Americans— and finding cures, science supported by the NIH.A clip from our conversationThe audio is available on iTunes and Spotify. The full video is linked here, at the top, and also can be found on YouTube.Transcript with audio and external linksEric Topol (00:06):Well, hello. This is Eric Topol from Ground Truths, and I am really delighted to welcome today, Anna Greka. Anna is the president of the American Society for Clinical Investigation (ASCI) this year, a very prestigious organization, but she's also at Mass General Brigham, a nephrologist, a cell biologist, a physician-scientist, a Core Institute Member of the Broad Institute of MIT and Harvard, and serves as a member of the institute's Executive Leadership Team. So we got a lot to talk about of all these different things you do. You must be pretty darn unique, Anna, because I don't know any cell biologists, nephrologists, physician-scientist like you.Anna Greka (00:48):Oh, thank you. It's a great honor to be here and glad to chat with you, Eric.Eric Topol (00:54):Yeah. Well, I had the real pleasure to hear you speak at a November conference, the AI for Science Forum, which we'll link to your panel. Where I was in a different panel, but you spoke about your extraordinary work and it became clear that we need to get you on Ground Truths, so you can tell your story to everybody. So I thought rather than kind of going back from the past where you were in Greece and somehow migrated to Boston and all that. We're going to get to that, but you gave an amazing TED Talk and it really encapsulated one of the many phenomenal stories of your work as a molecular sleuth. So maybe if you could give us a synopsis, and of course we'll link to that so people could watch the whole talk. But I think that Mucin-1 or MUC1, as you call it, discovery is really important to kind of ground our discussion.A Mysterious Kidney Disease Unraveled Anna Greka (01:59):Oh, absolutely. Yeah, it's an interesting story. In some ways, in my TED Talk, I highlight one of the important families of this story, a family from Utah, but there's also other important families that are also part of the story. And this is also what I spoke about in London when we were together, and this is really sort of a medical mystery that initially started on the Mediterranean island of Cyprus, where it was found that there were many families in which in every generation, several members suffered and ultimately died from what at the time was a mysterious kidney disease. This was more than 30 years ago, and it was clear that there was something genetic going on, but it was impossible to identify the gene. And then even with the advent of Next-Gen sequencing, this is what's so interesting about this story, it was still hard to find the gene, which is a little surprising.Anna Greka (02:51):After we were able to sequence families and identify monogenic mutations pretty readily, this was still very resistant. And then it actually took the firepower of the Broad Institute, and it's actually from a scientific perspective, an interesting story because they had to dust off the old-fashioned Sanger sequencing in order to get this done. But they were ultimately able to identify this mutation in a VNTR region of the MUC1 gene. The Mucin-1 gene, which I call a dark corner of the human genome, it was really, it's highly repetitive, very GC-rich. So it becomes very difficult to sequence through there with Next-Gen sequencing. And so, ultimately the mutation of course was found and it's a single cytosine insertion in a stretch of cytosines that sort of causes this frameshift mutation and an early stop codon that essentially results in a neoprotein like a toxic, what I call a mangled protein that sort of accumulates inside the kidney cells.Anna Greka (03:55):And that's where my sort of adventure began. It was Eric Lander's group, who is the founding director of the Broad who discovered the mutation. And then through a conversation we had here in Boston, we sort of discovered that there was an opportunity to collaborate and so that's how I came to the Broad, and that's the beginnings of this story. I think what's fascinating about this story though, that starts in a remote Mediterranean island and then turns out to be a disease that you can find in every continent all over the world. There are probably millions of patients with kidney disease in whom we haven't recognized the existence of this mutation. What's really interesting about it though is that what we discovered is that the mangled protein that's a result of this misspelling of this mutation is ultimately captured by a family of cargo receptors, they're called the TMED cargo receptors and they end up sort of grabbing these misfolded proteins and holding onto them so tight that it's impossible for the cell to get rid of them.Anna Greka (04:55):And they become this growing heap of molecular trash, if you will, that becomes really hard to manage, and the cells ultimately die. So in the process of doing this molecular sleuthing, as I call it, we actually also identified a small molecule that actually disrupts these cargo receptors. And as I described in my TED Talk, it's a little bit like having these cargo trucks that ultimately need to go into the lysosome, the cells recycling facility. And this is exactly what this small molecule can do. And so, it was just like a remarkable story of discovery. And then I think the most exciting of all is that these cargo receptors turn out to be not only relevant to this one mangled misshapen protein, but they actually handle a completely different misshapen protein caused by a different genetic mutation in the eye, causing retinitis pigmentosa, a form of blindness, familial blindness. We're now studying familial Alzheimer's disease that's also involving these cargo receptors, and there are other mangled misshapen proteins in the liver, in the lung that we're now studying. So this becomes what I call a node, like a nodal mechanism that can be targeted for the benefit of many more patients than we had previously thought possible, which has been I think, the most satisfying part about this story of molecular sleuthing.Eric Topol (06:20):Yeah, and it's pretty extraordinary. We'll put the figure from your classic Cell paper in 2019, where you have a small molecule that targets the cargo receptor called TMED9.Anna Greka (06:34):Correct.Expanding the MissionEric Topol (06:34):And what's amazing about this, of course, is the potential to reverse this toxic protein disease. And as you say, it may have applicability well beyond this MUC1 kidney story, but rather eye disease with retinitis pigmentosa and the familial Alzheimer's and who knows what else. And what's also fascinating about this is how, as you said, there were these limited number of families with the kidney disease and then you found another one, uromodulin. So there's now, as you say, thousands of families, and that gets me to part of your sleuth work is not just hardcore science. You started an entity called the Ladders to Cures (L2C) Scientific Accelerator.Eric Topol (07:27):Maybe you can tell us about that because this is really pulling together all the forces, which includes the patient advocacy groups, and how are we going to move forward like this?Anna Greka (07:39):Absolutely. I think the goal of the Ladders to Cures Accelerator, which is a new initiative that we started at the Broad, but it really encompasses many colleagues across Boston. And now increasingly it's becoming sort of a national, we even have some international collaborations, and it's only two years that it's been in existence, so we're certainly in a growth mode. But the inspiration was really some of this molecular sleuthing work where I basically thought, well, for starters, it cannot be that there's only one molecular node, these TMED cargo receptors that we discovered there's got to be more, right? And so, there's a need to systematically go and find more nodes because obviously as anyone who works in rare genetic diseases will tell you, the problem for all of us is that we do what I call hand to hand combat. We start with the disease with one mutation, and we try to uncover the mechanism and then try to develop therapies, and that's wonderful.Anna Greka (08:33):But of course, it's slow, right? And if we consider the fact that there are 30 million patients in the United States in every state, everywhere in the country who suffer from a rare genetic disease, most of them, more than half of them are children, then we can appreciate the magnitude of the problem. Out of more than 8,000 genes that are involved in rare genetic diseases, we barely have something that looks like a therapy for maybe 500 of them. So there's a huge mismatch in the unmet need and magnitude of the problem. So the Ladders to Cures Accelerator is here to address this and to do this with the most modern tools available. And to your point, Eric, to bring patients along, not just as the recipients of whatever we discover, but also as partners in the research enterprise because it's really important to bring their perspectives and of course their partnerships in things like developing appropriate biomarkers, for example, for what we do down the road.Anna Greka (09:35):But from a fundamental scientific perspective, this is basically a project that aims to identify every opportunity for nodes, underlying all rare genetic diseases as quickly as possible. And this was one of the reasons I was there at the AI for Science Forum, because of course when one undertakes a project in which you're basically, this is what we're trying to do in the Ladders to Cures Accelerator, introduce dozens of thousands of missense and nonsense human mutations that cause genetic diseases, simultaneously introduce them into multiple human cells and then use modern scalable technology tools. Things like CRISPR screens, massively parallel CRISPR screens to try to interrogate all of these diseases in parallel, identify the nodes, and then develop of course therapeutic programs based on the discovery of these nodes. This is a massive data generation project that is much needed and in addition to the fact that it will help hopefully accelerate our approach to all rare diseases, genetic diseases. It is also a highly controlled cell perturbation dataset that will require the most modern tools in AI, not only to extract the data and understand the data of this dataset, but also because this, again, an extremely controlled, well controlled cell perturbation dataset can be used to train models, train AI models, so that in the future, and I hope this doesn't sound too futuristic, but I think that we're all aiming for that cell biologists for sure dream of this moment, I think when we can actually have in silico the opportunity to make predictions about what cell behaviors are going to look like based on a new perturbation that was not in the training set. So an experiment that hasn't yet been done on a cell, a perturbation that has not been made on a human cell, what if like a new drug, for example, or a new kind of perturbation, a new chemical perturbation, how would it affect the behavior of the cell? Can we make a predictive model for that? This doesn't exist today, but I think this is something, the cell prediction model is a big question for biology for the future. And so, I'm very energized by the opportunity to both address this problem of rare monogenic diseases that remains an unmet need and help as many patients as possible while at the same time advancing biology as much as we possibly can. So it's kind of like a win-win lifting all boats type of enterprise, hopefully.Eric Topol (12:11):Yeah. Well, there's many things to get to unpack what you've just been reviewing. So one thing for sure is that of these 8,000 monogenic diseases, they have relevance to the polygenic common diseases, of course. And then also the fact that the patient family advocates, they are great at scouring the world internet, finding more people, bringing together communities for each of these, as you point out aptly, these rare diseases cumulatively are high, very high proportion, 10% of Americans or more. So they're not so rare when you think about the overall.Anna Greka (12:52):Collectively.Help From the Virtual Cell?Eric Topol (12:53):Yeah. Now, and of course is this toxic proteinopathies, there's at least 50 of these and the point that people have been thinking until now that, oh, we found a mangled protein, but what you've zeroed in on is that, hey, you know what, it's not just a mangled protein, it's how it gets stuck in the cell and that it can't get to the lysosome to get rid of it, there's no waste system. And so, this is such fundamental work. Now that gets me to the virtual cell story, kind of what you're getting into. I just had a conversation with Charlotte Bunne and Steve Quake who published a paper in December on the virtual cell, and of course that's many years off, but of course it's a big, bold, ambitious project to be able to say, as you just summarized, if you had cells in silico and you could do perturbations in silico, and of course they were validated by actual experiments or bidirectionally the experiments, the real ones helped to validate the virtual cell, but then you could get a true acceleration of your understanding of cell biology, your field of course.Anna Greka (14:09):Exactly.Eric Topol (14:12):So what you described, is it the same as a virtual cell? Is it kind of a precursor to it? How do you conceive this because this is such a complex, I mean it's a fundamental unit of life, but it's also so much more complex than a protein or an RNA because not only all the things inside the cell, inside all these organelles and nucleus, but then there's all the outside interactions. So this is a bold challenge, right?Anna Greka (14:41):Oh my god, it's absolutely from a biologist perspective, it's the challenge of a generation for sure. We think taking humans to Mars, I mean that's an aspirational sort of big ambitious goal. I think this is the, if you will, the Mars shot for biology, being able to, whether the terminology, whether you call it a virtual cell. I like the idea of saying that to state it as a problem, the way that people who think about it from a mathematics perspective for example, would think about it. I think stating it as the cell prediction problem appeals to me because it actually forces us biologists to think about setting up the way that we would do these cell perturbation data sets, the way we would generate them to set them up to serve predictions. So for example, the way that I would think about this would be can I in the future have so much information about how cell perturbations work that I can train a model so that it can predict when I show it a picture of another cell under different conditions that it hasn't seen before, that it can still tell me, ah, this is a neuron in which you perturbed the mitochondria, for example, and now this is sort of the outcome that you would expect to see.Anna Greka (16:08):And so, to be able to have this ability to have a model that can have the ability to predict in silico what cells would look like after perturbation, I think that's sort of the way that I think about this problem. It is very far away from anything that exists today. But I think that the beginning starts, and this is one of the unique things about my institute, if I can say, we have a place where cell biologists, geneticists, mathematicians, machine learning experts, we all come together in the same place to really think and grapple with these problems. And of course we're very outward facing, interacting with scientists all across the world as well. But there's this sort of idea of bringing people into one institute where we can just think creatively about these big aspirational problems that we want to solve. I think this is one of the unique things about the ecosystem at the Broad Institute, which I'm proud to be a part of, and it is this kind of out of the box thinking that will hopefully get us to generate the kinds of data sets that will serve the needs of building these kinds of models with predictive capabilities down the road.Anna Greka (17:19):But as you astutely said, AlphaFold of course was based on the protein database existing, right? And that was a wealth of available information in which one could train models that would ultimately be predictive, as we have seen this miracle that Demi Hassabis and John Jumper have given to humanity, if you will.Anna Greka (17:42):But as Demis and John would also say, I believe is as I have discussed with them, in fact, the cell prediction problem is really a bigger problem because we do not have a protein data bank to go to right now, but we need to create it to generate these data. And so, my Ladders to Cures Accelerator is here to basically provide some part of the answer to that problem, create this kind of well-controlled database that we need for cell perturbations, while at the same time maximizing our learnings about these fully penetrant coding mutations and what their downstream sequelae would be in many different human cells. And so, in this way, I think we can both advance our knowledge about these monogenic diseases, build models, hopefully with predictive capabilities. And to your point, a lot of what we will learn about this biology, if we think that it involves 8,000 or more out of the 20,000 genes in our genome, it will of course serve our understanding of polygenic diseases ultimately as well as we go deeper into this biology and we look at the combinatorial aspects of what different mutations do to human cells. And so, it's a huge aspirational problem for a whole generation, but it's a good one to work on, I would say.Learning the Language of Life with A.I. Eric Topol (19:01):Oh, absolutely. Now I think you already mentioned something that's quite, well, two things from what you just touched on. One of course, how vital it is to have this inner or transdisciplinary capability because you do need expertise across these vital areas. But the convergence, I mean, I love your term nodal biology and the fact that there's all these diseases like you were talking about, they do converge and nodal is a good term to highlight that, but it's not. Of course, as you mentioned, we have genome editing which allows to look at lots of different genome perturbations, like the single letter change that you found in MUC1 pathogenic critical mutation. There's also the AI world which is blossoming like I've never seen. In fact, I had in Science this week about learning the language of life with AI and how there's been like 15 new foundation models, DNA, proteins, RNA, ligands, all their interactions and the beginning of the cell story too with the human cell.Eric Topol (20:14):So this is exploding. As you said, the expertise in computer science and then this whole idea that you could take these powerful tools and do as you said, which is the need to accelerate, we just can't sit around here when there's so much discovery work to be done with the scalability, even though it might take years to get to this artificial intelligence virtual cell, which I have to agree, everyone in biology would say that's the holy grail. And as you remember at our conference in London, Demi Hassabis said that's what we'd like to do now. So it has the attention of leaders in AI around the world, obviously in the science and the biomedical community like you and many others. So it is an extraordinary time where we just can't sit still with these tools that we have, right?Anna Greka (21:15):Absolutely. And I think this is going to be, you mentioned the ASCI presidency in the beginning of our call. This is going to be the president gets to give an address at the annual meeting in Chicago. This is going to be one of the points I make, no matter what field in biomedicine we're in, we live in, I believe, a golden era and we have so many tools available to us that we can really accelerate our ability to help more patients. And of course, this is our mandate, the most important stakeholders for everything that we do as physician-scientists are our patients ultimately. So I feel very hopeful for the future and our ability to use these tools and to really make good on the promise of research is a public good. And I really hope that we can advance our knowledge for the benefit of all. And this is really an exciting time, I think, to be in this field and hopefully for the younger colleagues a time to really get excited about getting in there and getting involved and asking the big questions.Career ReflectionsEric Topol (22:21):Well, you are the prototype for this and an inspiration to everyone really, I'm sure to your lab group, which you highlighted in the TED Talk and many other things that you do. Now I want to spend a little bit of time about your career. I think it's fascinating that you grew up in Greece and your father's a nephrologist and your mother's a pathologist. So you had two physicians to model, but I guess you decided to go after nephrology, which is an area in medicine that I kind of liken it to Rodney Dangerfield, he doesn't get any respect. You don't see many people that go into nephrology. But before we get to your decision to do that somehow or other you came from Greece to Harvard for your undergrad. How did you make that connect to start your college education? And then subsequently you of course you stayed in Boston, you've never left Boston, I think.Anna Greka (23:24):I never left. Yeah, this is coming into 31 years now in Boston.Anna Greka (23:29):Yeah, I started as a Harvard undergraduate and I'm now a full professor. It's kind of a long, but wonderful road. Well, actually I would credit my parents. You mentioned that my father, they're both physician-scientists. My father is now both retired, but my father is a nephrologist, and my mother is a pathologist, actually, they were both academics. And so, when we were very young, we lived in England when my parents were doing postdoctoral work. That was actually a wonderful gift that they gave me because I became bilingual. It was a very young age, and so that allowed me to have this advantage of being fluent in English. And then when we moved back to Greece where I grew up, I went to an American school. And from that time, this is actually an interesting story in itself. I'm very proud of this school.Anna Greka (24:22):It's called Anatolia, and it was founded by American missionaries from Williams College a long time ago, 150 and more years ago. But it is in Thessaloniki, Greece, which is my hometown, and it's a wonderful institution, which gave me a lot of gifts as well, preparing me for coming to college in the United States. And of course, I was a good student in high school, but what really was catalytic was that I was lucky enough to get a scholarship to go to Harvard. And that was really, you could say the catalyst that propelled me from a teenager who was dreaming about a career as a physician-scientist because I certainly was for as far back as I remember in fact. But then to make that a reality, I found myself on the Harvard campus initially for college, and then I was in the combined Harvard-MIT program for my MD PhD. And then I trained in Boston at Mass General in Brigham, and then sort of started my academic career. And that sort of brings us to today, but it is an unlikely story and one that I feel still very lucky and blessed to have had these opportunities. So for sure, it's been wonderful.Eric Topol (25:35):We're the ones lucky that you came here and set up shop and you did your productivity and discovery work and sleuthing has been incredible. But I do think it's interesting too, because when you did your PhD, it was in neuroscience.Anna Greka (25:52):Ah, yes. That's another.Eric Topol (25:54):And then you switch gears. So tell us about that?Anna Greka (25:57):This is interesting, and actually I encourage more colleagues to think about it this way. So I have always been driven by the science, and I think that it seems a little backward to some people, but I did my PhD in neuroscience because I was interested in understanding something about these ion channels that were newly discovered at the time, and they were most highly expressed in the brain. So here I was doing work in the brain in the neuroscience program at Harvard, but then once I completed my PhD and I was in the middle of my residency training actually at Mass General, I distinctly remember that there was a paper that came out that implicated the same family of ion channels that I had spent my time understanding in the brain. It turned out to be a channelopathy that causes kidney disease.Anna Greka (26:43):So that was the light bulb, and it made me realize that maybe what I really wanted to do is just follow this thread. And my scientific curiosity basically led me into studying the kidney and then it seemed practical therefore to get done with my clinical training as efficiently as possible. So I finished residency, I did nephrology training, and then there I was in the lab trying to understand the biology around this channelopathy. And that sort of led us into the early projects in my young lab. And in fact, it's interesting we didn't talk about that work, but that work in itself actually has made it all the way to phase II trials in patients. This was a paper we published in Science in 2017 and follow onto that work, there was an opportunity to build this into a real drug targeting one of these ion channels that has made it into phase II trials. And we'll see what happens next. But it's this idea of following your scientific curiosity, which I also talked about in my TED Talk, because you don't know to what wonderful places it will lead you. And quite interestingly now my lab is back into studying familial Alzheimer's and retinitis pigmentosa in the eye in brain. So I tell people, do not limit yourself to whatever someone says your field is or should be. Just follow your scientific curiosity and usually that takes you to a lot more interesting places. And so, that's certainly been a theme from my career, I would say.Eric Topol (28:14):No, I think that's perfect. Curiosity driven science is not the term. You often hear hypothesis driven or now with AI you hear more AI exploratory science. But no, that's great. Now I want to get a little back to the AI story because it's so fascinating. You use lots of different types of AI such as cellular imaging would be fusion models and drug discovery. I mean, you've had drug discovery for different pathways. You mentioned of course the ion channel and then also as we touched on with your Cell paper, the whole idea of targeting the cargo receptor with a small molecule and then things in between. You discussed this of course at the London panel, but maybe you just give us the skinny on the different ways that you incorporate AI in the state-of-the-art science that you're doing?Anna Greka (29:17):Sure, yeah, thank you. I think there are many ways in which even for quite a long time before AI became such a well-known kind of household term, if you will, the concept of machine learning in terms of image processing is something that has been around for some time. And so, this is actually a form of AI that we use in order to process millions of images. My lab has by produced probably more than 20 million images over the last few years, maybe five to six years. And so, if you can imagine it's impossible for any human to process this many images and make sense of them. So of course, we've been using machine learning that is becoming increasingly more and more sophisticated and advanced in terms of being able to do analysis of images, which is a lot of what we cell biologists do, of course.Anna Greka (30:06):And so, there's multiple different kinds of perturbations that we do to cells, whether we're using CRISPR or base editing to make, for example, genome wide or genome scale perturbations or small molecules as we have done as well in the past. These are all ways in which we are then using machine learning to read out the effects in images of cells that we're looking at. So that's one way in which machine learning is used in our daily work, of course, because we study misshape and mangled proteins and how they are recognized by these cargo receptors. We also use AlphaFold pretty much every day in my lab. And this has been catalytic for us as a tool because we really are able to accelerate our discoveries in ways that were even just three or four years ago, completely impossible. So it's been incredible to see how the young people in my lab are just so excited to use these tools and they're becoming extremely savvy in using these tools.Anna Greka (31:06):Of course, this is a new generation of scientists, and so we use AlphaFold all the time. And this also has a lot of implications of course for some of the interventions that we might think about. So where in this cargo receptor complex that we study for example, might we be able to fit a drug that would disrupt the complex and lead the cargo tracks into the lysosome for degradation, for example. So there's many ways in which AI can be used for all of these functions. So I would say that if we were to organize our thinking around it, one way to think about the use of machine learning AI is around what I would call understanding biology in cells and what in sort of more kind of drug discovery terms you would call target identification, trying to understand the things that we might want to intervene on in order to have a benefit for disease.Anna Greka (31:59):So target ID is one area in which I think machine learning and AI will have a catalytic effect as they already are. The other of course, is in the actual development of the appropriate drugs in a rational way. So rational drug design is incredibly enabled by AlphaFold and all these advances in terms of understanding protein structures and how to fit drugs into them of all different modalities and kinds. And I think an area that we are not yet harnessing in my group, but I think the Ladders to Cures Accelerator hopes to build on is really patient data. I think that there's a lot of opportunity for AI to be used to make sense of medical records for example and how we extract information that would tell us that this cohort of patients is a better cohort to enroll in your trial versus another. There are many ways in which we can make use of these tools. Not all of them are there yet, but I think it's an exciting time for being involved in this kind of work.Eric Topol (32:58):Oh, no question. Now it must be tough when you know the mechanism of these families disease and you even have a drug candidate, but that it takes so long to go from that to helping these families. And what are your thoughts about that, I mean, are you thinking also about genome editing for some of these diseases or are you thinking to go through the route of here's a small molecule, here's the tox data in animal models and here's phase I and on and on. Where do you think because when you know so much and then these people are suffering, how do you bridge that gap?Anna Greka (33:39):Yeah, I think that's an excellent question. Of course, having patients as our partners in our research is incredible as a way for us to understand the disease, to build biomarkers, but it is also exactly creating this kind of emotional conflict, if you will, because of course, to me, honesty is the best policy, if you will. And so, I'm always very honest with patients and their families. I welcome them to the lab so they can see just how long it takes to get some of these things done. Even today with all the tools that we have, of course there are certain things that are still quite slow to do. And even if you have a perfect drug that looks like it fits into the right pocket, there may still be some toxicity, there may be other setbacks. And so, I try to be very honest with patients about the road that we're on. The small molecule path for the toxic proteinopathies is on its way now.Anna Greka (34:34):It's partnered with a pharmaceutical company, so it's on its way hopefully to patients. Of course, again, this is an unpredictable road. Things can happen as you very well know, but I'm at least glad that it's sort of making its way there. But to your point, and I'm in an institute where CRISPR was discovered, and base editing and prime editing were discovered by my colleagues here. So we are in fact looking at every other modality that could help with these diseases. We have several hurdles to overcome because in contrast to the liver and the brain, the kidney for example, is not an organ in which you can easily deliver nucleic acid therapies, but we're making progress. I have a whole subgroup within the bigger group who's focusing on this. It's actually organized in a way where they're running kind of independently from the cell biology group that I run.Anna Greka (35:31):And it's headed by a person who came from industry so that she has the opportunity to really drive the project the way that it would be run milestone driven, if you will, in a way that it would be run as a therapeutics program. And we're really trying to go after all kinds of different nucleic acid therapies that would target the mutations themselves rather than the cargo receptors. And so, there's ASO and siRNA technologies and then also actual gene editing technologies that we are investigating. But I would say that some of them are closer than others. And again, to your question about patients, I tell them honestly when a project looks to be more promising, and I also tell them when a project looks to have hurdles and that it will take long and that sometimes I just don't know how long it will take before we can get there. The only thing that I can promise patients in any of our projects, whether it's Alzheimer's, blindness, kidney disease, all I can promise is that we're working the hardest we possibly can on the problem.Anna Greka (36:34):And I think that is often reassuring I have found to patients, and it's best to be honest about the fact that these things take a long time, but I do think that they find it reassuring that someone is on it essentially, and that there will be some progress as we move forward. And we've made progress in the very first discovery that came out of my lab. As I mentioned to you, we've made it all the way to phase II trials. So I have seen the trajectory be realized, and I'm eager to make it happen again and again as many times as I can within my career to help as many people as possible.The Paucity of Physician-ScientistsEric Topol (37:13):I have no doubts that you'll be doing this many times in your career. No, there's no question about it. It's extraordinary actually. There's a couple of things there I want to pick up on. Physician-scientists, as you know, are a rarefied species. And you have actually so nicely told the story about when you have a physician-scientist, you're caring for the patients that you're researching, which is, most of the time we have scientists. Nothing wrong with them of course, but you have this hinge point, which is really important because you're really hearing the stories and experiencing the patients and as you say, communicating about the likelihood of being able to come up with a treatment or the progress. What are we going to do to get more physician-scientists? Because this is a huge problem, it has been for decades, but the numbers just keep going lower and lower.Anna Greka (38:15):I think you're absolutely right. And this is again, something that in my leadership of the ASCI I have made sort of a cornerstone of our efforts. I think that it has been well-documented as a problem. I think that the pressures of modern clinical care are really antithetical to the needs of research, protected time to really be able to think and be creative and even have the funding available to be able to pursue one's program. I think those pressures are becoming so heavy for investigators that many of them kind of choose one or the other route most often the clinical route because that tends to be, of course where they can support their families better. And so, this has been kind of the conundrum in some ways that we take our best and brightest medical students who are interested in investigation, we train them and invest in them in becoming physician-scientists, but then we sort of drop them at the most vulnerable time, which is usually after one completes their clinical and scientific training.Anna Greka (39:24):And they're embarking on early phases of one's careers. It has been found to be a very vulnerable point when a lot of people are now in their mid-thirties or even late thirties perhaps with some family to take care of other burdens of adulthood, if you will. And I think what it becomes very difficult to sustain a career where one salary is very limited due to the research component. And so, I think we have to invest in our youngest people, and it is a real issue that there's no good mechanism to do that at the present time. So I was actually really hoping that there would be an opportunity with leadership at the NIH to really think about this. It's also been discussed at the level of the National Academy of Medicine where I had some role in discussing the recent report that they put out on the biomedical enterprise in the United States. And it's kind of interesting to see that there is a note made there about this issue and the fact that there needs to be, I think, more generous investment in the careers of a few select physician-scientists that we can support. So if you look at the numbers, currently out of the entire physician workforce, a physician-scientist comprised of less than 1%.Anna Greka (40:45):It's probably closer to 0.8% at this point.Eric Topol (40:46):No, it's incredible.Anna Greka (40:48):So that's really not enough, I think, to maintain the enterprise and if you will, this incredible innovation economy that the United States has had this miracle engine, if you will, in biomedicine that has been fueled in large part by physician investigators. Of course, our colleagues who are non-physician investigators are equally important partners in this journey. But we do need a few of the physician-scientists investigators I think as well, if you really think about the fact that I think 70% of people who run R&D programs in all the big pharmaceutical companies are physician-scientists. And so, we need people like us to be able to work on these big problems. And so, more investment, I think that the government, the NIH has a role to play there of course. And this is important from both an economic perspective, a competition perspective with other nations around the world who are actually heavily investing in the physician-scientist workforce.Anna Greka (41:51):And I think it's also important to do so through our smaller scale efforts at the ASCI. So one of the things that I have been involved in as a council member and now as president is the creation of an awards program for those early career investigators. So we call them the Emerging-Generation Awards, and we also have the Young Physician-Scientist Awards. And these are really to recognize people who are making that transition from being kind of a trainee and a postdoc and have finished their clinical training into becoming an independent assistant professor. And so, those are small awards, but they're kind of a symbolic tap on the shoulder, if you will, that the ASCI sees you, you're talented, stay the course. We want you to become a future member. Don't give up and please keep on fighting. I think that can take us only so far.Anna Greka (42:45):I mean, unless there's a real investment, of course still it will be hard to maintain people in the pipeline. But this is just one way in which we have tried to, these programs that the ASCI offers have been very successful over the last few years. We create a cohort of investigators who are clearly recognized by members of the ASCI is being promising young colleagues. And we give them longitudinal training as part of a cohort where they learn about how to write a grant, how to write a paper, leadership skills, how to run a lab. And they're sort of like a buddy system as well. So they know that they're in it together rather than feeling isolated and struggling to get their careers going. And so, we've seen a lot of success. One way that we measure that is conversion into an ASCI membership. And so, we're encouraged by that, and we hope that the program can continue. And of course, as president, I'm going to be fundraising for that as well, it's part of the role. But it is a really worthy cause because to your point, we have to somehow make sure that our younger colleagues stay the course that we can at least maintain, if not bolster our numbers within the scientific workforce.Eric Topol (43:57):Well, you outlined some really nice strategies and plans. It's a formidable challenge, of course. And we'd like to see billions of dollars to support this. And maybe someday we will because as you say, if we could relieve the financial concerns of people who have curiosity driven ideas.Anna Greka (44:18):Exactly.Eric Topol (44:19):We could do a lot to replenish and build a big physician-scientist workforce. Now, the last thing I want to get to, is you have great communication skills. Obviously, anybody who is listening or watching this.Eric Topol (44:36):Which is another really important part of being a scientist, no less a physician or the hybrid of the two. But I wanted to just go to the backstory because your TED Talk, which has been watched by hundreds of thousands of people, and I'm sure there's hundreds of thousands more that will watch it, but the TED organization is famous for making people come to the place a week ahead. This is Vancouver used to be in LA or Los Angeles area and making them rehearse the talk, rehearse, rehearse, rehearse, which seems crazy. You could train the people there, how to give a talk. Did you have to go through that?Anna Greka (45:21):Not really. I did rehearse once on stage before I actually delivered the talk live. And I was very encouraged by the fact that the TED folks who are of course very well calibrated, said just like that. It's great, just like that.Eric Topol (45:37):That says a lot because a lot of people that do these talks, they have to do it 10 times. So that kind of was another metric. But what I don't like about that is it just because these people almost have to memorize their talks from giving it so much and all this coaching, it comes across kind of stilted and unnatural, and you're just a natural great communicator added to all your other things.Anna Greka (46:03):I think it's interesting. Actually, I would say, if I may, that I credit, of course, I actually think that it's important, for us physician-scientists, again, science and research is a public good, and being able to communicate to the public what it is that we do, I think is kind of an obligation for the fact that we are funded by the public to do this kind of work. And so, I think that's important. And I always wanted to cultivate those communication skills for the benefit of communicating simply and clearly what it is that we do in our labs. But also, I would say as part of my story, I mentioned that I had the opportunity to attend a special school growing up in Greece, Anatolia, which was an American school. One of the interesting things about that is that there was an oratory competition.Anna Greka (46:50):I got very early exposure entering that competition. And if you won the first prize, it was in the kind of ancient Rome way, first among equals, right? And so, that was the prize. And I was lucky to have this early exposure. This is when I was 14, 15, 16 years old, that I was training to give these oratory speeches in front of an audience and sort of compete with other kids who were doing the same. I think these are just wonderful gifts that a school can give a student that have stayed with me for life. And I think that that's a wonderful, yeah, I credit that experience for a lot of my subsequent capabilities in this area.Eric Topol (47:40):Oh, that's fantastic. Well, this has been such an enjoyable conversation, Anna. Did I miss anything that we need to bring up, or do you think we have it covered?Anna Greka (47:50):Not at all. No, this was wonderful, and I thoroughly enjoyed it as well. I'm very honored seeing how many other incredible colleagues you've had on the show. It's just a great honor to be a part of this. So thank you for having me.Eric Topol (48:05):Well, you really are such a great inspiration to all of us in the biomedical community, and we'll be cheering for your continued success and thanks so much for joining today, and I look forward to the next time we get a chance to visit.Anna Greka (48:20):Absolutely. Thank you, Eric.**************************************Thanks for listening, watching or reading Ground Truths. Your subscription is greatly appreciated.If you found this podcast interesting please share it!That makes the work involved in putting these together especially worthwhile.All content on Ground Truths—newsletters, analyses, and podcasts—is free, open-access.Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. And such support is becoming more vital In light of current changes of funding and support for biomedical research at NIH and other US governmental agencies.Thanks to my producer Jessica Nguyen and to Sinjun Balabanoff for audio and video support at Scripps Research. Get full access to Ground Truths at erictopol.substack.com/subscribe

Amanda is feeling frazzled but doesn't have a full moon to blame (but at least her basement is clean), and Brooke scored a Le Creuset beauty while she leans further into her scam/cult/murder documentary era. The ladies then touch base on how they're incorporating more whimsy, humor, and rituals into their days.Amanda then shares an app that is helping her contact her representatives, and Brooke is doing her future self a favor while the flu runs rampant in her community.Visit www.goodenoughish.com for links to everything mentioned on the show.Support the podcast: Good Enough-ish on PatreonSnag Some Merch: goodenoughish.com/shopJoin the Good Enough-ish™ conversation in our private FB group: Good Enough-ish private Facebook groupIf you like this episode, please take a moment to share a positive review on Apple Podcasts, and share with others who may enjoy Good Enough-ish!We'll be back each week with new topics, stories, tips, and personal experiences, as well as some good old friendly banter and lots of laughter. Don't forget to find us on Instagram @goodenough.ish, or contact us with your episode ideas, questions, and comments.

Tommy talks with JP Morrell about what he saw on Mardi Gras day with all the things that usually clutter the parade route.

Discover the groundbreaking physics behind skyhooks, rotovators, and space ladders, and how they could revolutionize space travel in the near future.Watch my exclusive video The End of Science https://nebula.tv/videos/isaacarthur-the-end-of-scienceGet Nebula using my link for 40% off an annual subscription: https://go.nebula.tv/isaacarthurGet a Lifetime Membership to Nebula for only $300: https://go.nebula.tv/lifetime?ref=isaacarthurUse the link gift.nebula.tv/isaacarthur to give a year of Nebula to a friend for just $30.Visit our Website: http://www.isaacarthur.netJoin Nebula: https://go.nebula.tv/isaacarthurSupport us on Patreon: https://www.patreon.com/IsaacArthurSupport us on Subscribestar: https://www.subscribestar.com/isaac-arthurFacebook Group: https://www.facebook.com/groups/1583992725237264/Reddit: https://www.reddit.com/r/IsaacArthur/Twitter: https://twitter.com/Isaac_A_Arthur on Twitter and RT our future content.SFIA Discord Server: https://discord.gg/53GAShECredits:Skyhooks, Rotovators & Space LaddersEpisode 488b; March 2, 2025Written, Produced & Narrated by: Isaac ArthurGraphics: Jarred Eagley, Katie Byrne, Phil Swan, Sergio BoteroSelect imagery/video supplied by Getty Images Music Courtesy of Epidemic Sound http://epidemicsound.com/creatorPhase Shift, "Forest Night"Chris Zabriskie, "Unfoldment, Revealment", "A New Day in a New Sector", "Oxygen Garden", "Wonder Cycle"Stellardrone, "Red Giant", "Billions and Billions"See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Discover the groundbreaking physics behind skyhooks, rotovators, and space ladders, and how they could revolutionize space travel in the near future.Watch my exclusive video The End of Science https://nebula.tv/videos/isaacarthur-the-end-of-scienceGet Nebula using my link for 40% off an annual subscription: https://go.nebula.tv/isaacarthurGet a Lifetime Membership to Nebula for only $300: https://go.nebula.tv/lifetime?ref=isaacarthurUse the link gift.nebula.tv/isaacarthur to give a year of Nebula to a friend for just $30.Visit our Website: http://www.isaacarthur.netJoin Nebula: https://go.nebula.tv/isaacarthurSupport us on Patreon: https://www.patreon.com/IsaacArthurSupport us on Subscribestar: https://www.subscribestar.com/isaac-arthurFacebook Group: https://www.facebook.com/groups/1583992725237264/Reddit: https://www.reddit.com/r/IsaacArthur/Twitter: https://twitter.com/Isaac_A_Arthur on Twitter and RT our future content.SFIA Discord Server: https://discord.gg/53GAShECredits:Skyhooks, Rotovators & Space LaddersEpisode 488b; March 2, 2025Written, Produced & Narrated by: Isaac ArthurGraphics: Jarred Eagley, Katie Byrne, Phil Swan, Sergio BoteroSelect imagery/video supplied by Getty Images Music Courtesy of Epidemic Sound http://epidemicsound.com/creatorPhase Shift, "Forest Night"Chris Zabriskie, "Unfoldment, Revealment", "A New Day in a New Sector", "Oxygen Garden", "Wonder Cycle"Stellardrone, "Red Giant", "Billions and Billions"See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Welcome to Arcade Church's Online service. We are so glad you are watching this week's sermon! The service is at 10 AM on Sundays. Watch our last sermon series, "Live Ready!": https://www.youtube.com/playlist?list=PLhBJrLsRRcp-xF__DzSNQjcPu-XJ-Tzv8 Want to watch more of our sermons? https://www.youtube.com/playlist?list=PLhBJrLsRRcp_POrw1b1XCBnG2Jrpv1hbO Check Out the Behold Podcast:  @behold.podcast   Do you have a prayer request? https://www.arcadechurchonline.com/prayer.  If you want to know more about Jesus, email us info@arcadechurchonline.com. Follow us on Social Media Instagram: @arcadechurch   Facebook: Arcade Church Visit us at www.arcadechurch.com

Join Tom Clarke and Gregor Robertson for all the latest news from the Championship, League One and League Two.Is it time to give Frank Lampard credit? His Coventry side are one point off the play offs and he is winning over the sky blues fans. Meanwhile another former international midfielder Michael Carrick is struggling at Middlesborough, what's gone wrong at the Riverside? As Tom watches a bore fest at Sincil Bank is now the time in the season when fatigue – mental and physical – starts to kick in? In League Two, AFC Wimbledon have the best defence in the league and are on a twelve game unbeaten run. And a few big teams are struggling. Plus a late surprise appearance from the next generation of footballing/journalistic talent… Hosted on Acast. See acast.com/privacy for more information.

In this episode of Advisor Revelations, Blake Phillips, Regional VP of Member Success at DPL, talks with DPL Internal Consultant Tyler Caummisar about MYGA ladders and why they are becoming a go-to strategy for advisors looking to optimize their clients' portfolios. From comparing MYGAs to traditional instruments like CDs and treasuries to understanding how laddering can diversify assets and mitigate interest rate risk, Tyler discusses how DPL's cutting-edge platform simplifies researching, purchasing, and managing annuities. Learn more at https://www.dplfp.com/series/advisor-revelations-podcast.

Upper West Side, Studio A/Henry's room, Portugal, Alana, Max, Lacie Foreht, European vibe, American vibe v. European vibe, Lisbon, Porto, Santiago de Compostela, Very European, Face-to-face communication, Walked, ate, drank, had a lovely time, Ren & Stimpy, Plumpy, Candyland, Board game, Move around the board by picking cards, Plumpy sent you back to the beginning, Trips to Florida with Gordon, Katie, Zachary, and Noah, Milo, Max, Alana, and Daryl, Playing Candyland with the boys and nephews, Daryl would spot Plumpy and set it aside, Uncle Daddy, Boys and nephews doing a song and dance about Uncle Daddy drawing Plumpy, Milo doing the robot, Boys continued to humor me over time, Noah must have known, All must have known eventually, Uncle Daddy got Plumpy dance, Like Chutes & Ladders, If someone's going to finish last it will be Uncle Daddy, Alana would play the boys in ping pong and beat them, Daryl struggled to allow himself to beat the boys at games, Alana and Daryl complementing each other in this way, Learned many important lessons about toughness and grit from Alana, and other lessons from Daryl, Alana is an amazing athlete and great tennis player, Daryl less good athlete and much less good tennis player, Daryl would feel bad for opponents, Not so Alana, Alana was routinely crushing people, Plumpy story is some evidence of the different approaches, Maybe Alana was also celebrating when Uncle Daddy got Plumpy

Callan Schoonenberg Steering technology strategy at Wausau Supply Company, Callan Schoonenberg brings mechanical engineering, business and extensive manufacturing experience to her CIO role. Her background includes leadership positions at Eaton, complemented by Harvard Business Analytics training and an MBA, creating a unique perspective on technology leadership. Building Modern Manufacturing IT What makes a non-traditional path...

Well winter is on our doorsteps, and for the general population any thoughts of gardening stops, as the common thought is the 'garden has gone to sleep'...Well nothing could be farther from the truth, as the season of shorter days and chilly weather could be one of the most important and busy in the yearly life of your garden. Join Lucy and Saul every week as they show you exactly how busy they are, whether getting everything festive for Xmas, clearing up after the latest storm, enjoying the emergent shoots of early flowering plants or getting ready for spring and a return to the start of the great garden cycle!This week, your favourite professional gardening duo ponder some key horticultural questions: why does Saul feel able to 'top' the grass in winter but not cut it, why did Lucy's 30,000 hydrostatic head waterproof coat fail her miserably (luckily her trousers didn't), does Saul sneakily line-dance around Stonelands when the owners are out, and why are tripod ladders so incredibly useful? Saul and Lucy also answer listener queries on what are the best gardening shows to visit in 2025, and Lucy concludes that Saul may not be completely convinced by her 'yogardening' concept....Twitter links:Saul @GardeningSaulInstagram links:Lucy lucychamberlaingardensIntro and Outro music from https://filmmusic.io"Fireflies and Stardust" by Kevin MacLeod (https://incompetech.com)License: CC BY (http://creativecommons.org/licenses/by/4.0/)Support the show

Pat Mayo and Tommy G give their Super Bowl LIX Predictions while providing Bets Extravaganza full of Props, Ladders, Fades, and two to Budget Bankroll for the Super Bowl. Use code “MAYO” at underdog for a deposit match up to $1000 VOTE IN THE CUSTYS: https://www.allcounted.com/s?did=3oamz966tx5oa&lang=en_US Get 20% off https://www.fantasynational.com/mayo with code “MAYO” Code “MAYO” 10% OFF at Ship It Nation: https://shipitnation.com/?aff=Thepme Subscribe, Rate and Review Apple: http://bit.ly/PMEiTunes Spotify: https://goo.gl/VboemH FOLLOW MAYO MEDIA NETWORK Newsletter: https://mayomedia.substack.com/ Instagram: https://www.instagram.com/mayomedianetwork/ TIK TOK: https://www.tiktok.com/discover/mayo-media-network YOUTUBE: https://bit.ly/YTMMN YOUTUBE: https://bit.ly/YTMMN SHOW INDEX 00:00 Intro 3:45 Super Bowl Predictions  10:48 How to Budget/3 Best Props 20:45 Bad Chalk/Ladder plays 36:20 Business Inventions TGL — To learn more, visit TGLgolf.com. And tune into the inaugural season on ESPN. SHIPSTICKS -- Go to shipsticks.com and use the code PATMAYO to get 20% off your first shipment AG1 -- FREE $76 gift & Welcome Kit when you sign up at DrinkAG1.com/mayo Message and data rates apply. Must be 18+ (21+MA & AZ, 19+ AL, NE) and present in a state where Underdog Fantasy operates. Terms apply. Concerned with your play? Call 1-800-GAMBLER or visit www.ncpgambling.org; AZ: 1-800-NEXT-STEP (1-800-639-8783) or text NEXT-STEP to 53342; NY: Call the 24/7 HOPEline at 1-877-8-HOPENY or Text HOPENY (467369) Learn more about your ad choices. Visit podcastchoices.com/adchoices

The guys (@GamblingPodcast) are talking for NFL player props in their Super Bowl 59 props ladders, leaders and first touchdown best bets episode. Sean (@SeanTGreen) Ryan (@KramerCentric) and joined by C.J. Sullivan (@CJSullivan_) from The Bottom Line Bombs to talk about their favorite Super Bowl prop bets.They give out their favorite Super Bowl 59 first touchdown bets with plays on guys like Jahan Dotson, Dallas Goedert and more. Additionally they talk Super Bowl game leader prop bets for guys like DeVonta Smith and JuJu Smith-Schuster.Go here for free NFL picks - https://www.sportsgamblingpodcast.com/nfl-picksPodcast Chapters00:00 Introduction00:52 Hosts' Banter and Kyle Juszczyk Prop Bet02:24 Guest Introduction and Super Bowl Week Discussion04:42 Super Bowl Party Plans and Betting Stories10:48 Ladders and First Touchdown Bets40:15 Noah Gray Dream Recap40:49 Betting on Juju and Jahan Dotson42:04 First Touchdown Predictions48:13 Underdog Fantasy Picks50:44 Playoff Leader Market Insights55:54 First Quarter and First Half Leaders01:03:16 Super Bowl Prop Bets01:15:20 Final Thoughts and Super Bowl Squares Exclusive SGPN Bonuses And Linkshttp://linktr.ee/sportsgamblingpodcastFollow The Sports Gambling Podcast X/Twitter - https://x.com/GamblingPodcastInstagram - https://www.instagram.com/sportsgamblingpodcastTikTok - https://www.tiktok.com/@gamblingpodcastFacebook - http://www.facebook.com/sportsgamblingpodcastFollow The Sports Gambling Podcast HostsSean Green - http://www.twitter.com/seantgreenRyan Kramer - http://www.twitter.com/kramercentric Gambling problem? Call 1-800-GAMBLER CO, DC, IL, IN, LA, MD, MS, NJ, OH, PA, TN, VA, WV, WY Call 877-8-HOPENY or text HOPENY (467369) (NY) Call 1-800-327-5050 (MA)21+ to wager. Please Gamble Responsibly. Call 1-800-NEXT-STEP (AZ), 1-800-522-4700 (KS, NV), 1-800 BETS-OFF (IA), 1-800-270-7117 for confidential help (MI)

The guys (@GamblingPodcast) are talking for NFL player props in their Super Bowl 59 props ladders, leaders and first touchdown best bets episode. Sean (@SeanTGreen) Ryan (@KramerCentric) and joined by C.J. Sullivan (@CJSullivan_) from The Bottom Line Bombs to talk about their favorite Super Bowl prop bets.They give out their favorite Super Bowl 59 first touchdown bets with plays on guys like Jahan Dotson, Dallas Goedert and more. Additionally they talk Super Bowl game leader prop bets for guys like DeVonta Smith and JuJu Smith-Schuster.Go here for free NFL picks - https://www.sportsgamblingpodcast.com/nfl-picksPodcast Chapters00:00 Introduction00:52 Hosts' Banter and Kyle Juszczyk Prop Bet02:24 Guest Introduction and Super Bowl Week Discussion04:42 Super Bowl Party Plans and Betting Stories10:48 Ladders and First Touchdown Bets40:15 Noah Gray Dream Recap40:49 Betting on Juju and Jahan Dotson42:04 First Touchdown Predictions48:13 Underdog Fantasy Picks50:44 Playoff Leader Market Insights55:54 First Quarter and First Half Leaders01:03:16 Super Bowl Prop Bets01:15:20 Final Thoughts and Super Bowl Squares Exclusive SGPN Bonuses And Linkshttp://linktr.ee/sportsgamblingpodcastFollow The Sports Gambling Podcast X/Twitter - https://x.com/GamblingPodcastInstagram - https://www.instagram.com/sportsgamblingpodcastTikTok - https://www.tiktok.com/@gamblingpodcastFacebook - http://www.facebook.com/sportsgamblingpodcastFollow The Sports Gambling Podcast HostsSean Green - http://www.twitter.com/seantgreenRyan Kramer - http://www.twitter.com/kramercentricGambling problem? Call 1-800-GAMBLER CO, DC, IL, IN, LA, MD, MS, NJ, OH, PA, TN, VA, WV, WY Call 877-8-HOPENY or text HOPENY (467369) (NY) Call 1-800-327-5050 (MA)21+ to wager. Please Gamble Responsibly. Call 1-800-NEXT-STEP (AZ), 1-800-522-4700 (KS, NV), 1-800 BETS-OFF (IA), 1-800-270-7117 for confidential help (MI)

The Black Rasslin' Podcast returns with their annual Royal Rumble preview show, but this year, it's a bit different! By order of Stat Guy Greg, the Lip Gloss & Ladders crew make their return once again for a special Predicitions Show / Trivia Rumble SHOWDOWN! ► Follow Lip Gloss & Ladders: https://x.com/lipglossladders https://x.com/_geniusRee https://x.com/hiigabrielle https://x.com/signedbenny https://x.com/MeticulousKi https://www.youtube.com/@LipGlossNLadders https://linktr.ee/lipglossnladders ► Follow Stat Guy Greg: https://x.com/StatGuyGreg https://open.spotify.com/show/336nip9eeSGE8529SxGDQQ https://youtube.com/playlist?list=PLQG6oLVxD-4zAtrHOcrwb4_PJAbzzV2Vh&si=K08sFOc4p2WmU8f_ Watch this episode on YouTube: https://youtube.com/live/FvsdBr7Q-_M Become a BRPatreon member: www.patreon.com/blackrasslin The Black Rasslin' Podcast Theme is produced by Anikan & Vader. www.instagram.com/anikanandvader Subscribe to The Black Rasslin' Podcast: YouTube: youtube.com/c/blackrasslin Apple Podcasts: bit.ly/blackrasslinIT Spotify: bit.ly/blackrasslinSP Google Podcasts: bit.ly/blackrasslinGP SoundCloud: @black-rasslin-podcast

Ever notice how the pros make everything look easy? That's because they have guides who know all the shortcuts. In this episode, David reveals why finding your own real estate "unicorn" – an experienced, caring guide – is the game-changer most first-time buyers miss. Learn why choosing the right team early unlocks hidden paths to homeownership and saves you thousands, even if you think you're not ready to buy.Quote"Finding and working all your options - that's the best play to success. And the right people, they have your best interests at heart, and your 'best interest' - that's a phrase that unicorn-type realtors and lenders don't take lightly."Episode HighlightsCould starting with a pre-qualification actually limit your homebuying options? Discover why David recommends finding your "unicorn" realtor before talking to lenders.What if everything you've read online about the first steps to buying a home is backward? Learn why the conventional wisdom about starting with a mortgage pre-qualification might be selling you short.Is your real estate agent just a "door opener"? Uncover the crucial differences between order-taking agents and true professional guides who can reveal paths to homeownership you didn't know existed.How much training do real estate agents actually receive? (Spoiler: It's less than your barber!) Find out why choosing experienced representation is more important than you think.What's the real reason most online advice tells you to get pre-qualified first? David exposes how "big mortgage" tries to capture buyers early and potentially limits their options.Could you be closer to homeownership than you think? Learn why 72% of David's listeners who thought they were 12-18 months away from buying were actually under contract in just over 3 months.Referenced EpisodesEpisode 5: The Biggest Dirty Little Secret in Real EstateEpisode 11: The Perils of Online LendersEpisode 16: Mortgage Broker vs BankEpisode 32: VA LoansEpisode 66: Getting the Best RateEpisode 153: Getting a Loan Right Out of CollegeEpisode 164: The Chutes and Ladders of HomebuyingEpisode 192: Why Google Sometimes SucksEpisode 229: Finding Your UnicornEpisode 242: Listener Lender QuestionsEpisode 261: More on Getting the Best RateEpisode 301: Homebuying 101Connect with me to find a trusted realtor in your area or to answer your burning questions!Subscribe to our YouTube Channel @HowToBuyaHomeInstagram @HowtoBuyAHomePodcastTik Tok @HowToBuyAHomeThis podcast was created for YOU - to cut through the confusion and empower you to buy your first home. Let's change how the real estate industry treats first-timers, one buyer at a time- starting with YOU!Visit our Resource Center to "Ask David" AND get your FREE Home Buying Starter Kit!David Sidoni, the "How to Buy a Home Guy," is a seasoned real estate professional and consumer advocate with over 18 years of experience helping first-time homebuyers navigate the real estate market. His podcast, "How to Buy a Home," is a trusted resource for anyone looking to buy their first home. It offers expert advice, actionable tips, and inspiring stories from real first-time homebuyers. With a focus on making the home-buying process accessible and understandable, David breaks down complex topics into easy-to-follow steps, covering everything from budgeting and financing to finding the right home and making an offer. Subscribe for regular market updates, and leave a review to help us reach more people. Ready for an honest, informed home-buying experience? Viva la Unicorn Revolution - join us!

On episode 48, we welcome comedian and writer, Ryan Beck, somewhere in the ring! We hear all about his history with wrestling and then we break down the first ever Tables, Ladders, and Chairs match, pitting The Dudley Boyz, The Hardy Boyz, and Edge and Christian against one another in one of the most death-defying matches in WWE history! Follow all of Ryan Beck's work at: https://linktr.ee/iamryanbeckWatch "Chemistry Test": https://www.youtube.com/watch?v=frkhmBFoJlE&t=309sPatreon: http://www.patreon.com/SomewhereintheRingPodcastByMeACoffee: http://www.buymeacoffee.com/UFxzyzHOaQFollow on BlueSky: https://bsky.app/profile/someringpod.bsky.socialFollow on Instagram: https://www.instagram.com/somewhereringpodFollow on Twitter: https://twitter.com/SomeRingPodFacebook Group: https://www.facebook.com/groups/424653323266736Email: SomewhereintheRing@gmail.comStore: http://tee.pub/lic/ULZAy7IY12U© Ryan Sprague, 2024. All Rights Reserved.Produced by LIONSGATE Hosted on Acast. See acast.com/privacy for more information.