Podcasts about circulating

Opponents of the Shady Grove redevelopment plan recently approved by city leadership are getting serious, and getting organized - Circulating petitions to force a referendum vote on the issue (at 14:48) --- Adulting is hard - And one of the hardest parts also may be one of the most unexpected... Young adults trying to figure out how to navigate the healthcare system for the first time (at 28:22) --- Around Town: Live music, great food and more... The second annual VetFest is a day-long community celebration of and for all those who have served (at 47:49)

Interview conducted on March 11, 2026, by Dr Neil Love, including the following topics: Circulating tumor DNA (ctDNA)-guided adjuvant therapy with atezolizumab for muscle-invasive bladder cancer (MIBC) (0:00) Use of ctDNA in guiding systemic treatment selection for patients with urothelial bladder cancer (10:03) ctDNA analyses with perioperative durvalumab for MIBC in the Phase III NIAGARA study (16:51) New research advances in the monitoring and management of urothelial bladder cancer (22:21) CME information and select publications  

As cancer vaccines move into Phase II and III clinical trials, it isincreasingly important for surgeons to understand their role in thisevolving landscape. What exactly are these vaccines, how do they work,and what should the surgical community know about theirimplementation? Join BTK surgical education fellows Kara Button andMichelle LaBella as they sit down with Professor Robert Jones to breakdown the science of mRNA vaccines, the logistics of tissueprocurement, and the future of cancer care.Hosts:- Professor Robert Jones: Consultant Liver Surgeon, Liverpool UniversityHospitals; UK National Institute for Healthcare Research, Co-Lead forthe Cancer Vaccine Innovation Pathway, Bowel Cancer UK and RoyalCollege of Surgeons UK Lead for Research into Advanced Bowel Cancer,and UK Chief Investigator for the BNT122-01 trial.https://www.linkedin.com/in/robert-jones-6103722a/- Kara Button, DO: General Surgery Resident, Maine Medical Center;Behind the Knife Surgical Education Fellow.- Michelle LaBella, MD: General Surgery Resident; University of NorthCarolina; Behind the Knife Surgical Education Fellow.References:https://clinicaltrials.biontech.com/trials/BNT122-01Jones RP, Lee LYW, Corrie PG, et al. Individualized cancer vaccinesversus surveillance after adjuvant chemotherapy for surgicallyresected high-risk stage 2 and stage 3 colorectal cancer: protocol fora randomized trial. BJS. 2023;110(12):1883-1884.doi:10.1093/bjs/znad332https://pubmed.ncbi.nlm.nih.gov/37856683/Tie J, Wang Y, Loree JM, et al. Circulating tumor DNA-guided adjuvanttherapy in locally advanced colon cancer: the randomized phase 2/3DYNAMIC-III trial. Nat Med. 2025;31(12):4291-4300.doi:10.1038/s41591-025-04030-whttps://pubmed.ncbi.nlm.nih.gov/41115959/Rojas LA, Sethna Z, Soares KC, et al. Personalized RNA neoantigenvaccines stimulate T cells in pancreatic cancer. Nature.2023;618(7963):144-150. doi:10.1038/s41586-023-06063-yhttps://pubmed.ncbi.nlm.nih.gov/37165196/https://www.cancer.ox.ac.uk/research/lynchvax#:~:text=The%20LynchVax%20program%2C%20funded%20by,individuals%20with%20this%20genetic%20conditionPlease visit https://behindtheknife.org to access other high-yield surgical education podcasts, videos and more.  If you liked this episode, check out our recent episodes here: https://behindtheknife.org/listenBehind the Knife Premium: https://behindtheknife.org/premiumOral Board Review: https://behindtheknife.org/oral-boardOral Board Simulator: https://behindtheknife.org/oral-board/simulatorGeneral Surgery Oral Board Review Course: https://behindtheknife.org/premium/general-surgery-oral-board-reviewTrauma Surgery Video Atlas: https://behindtheknife.org/premium/trauma-surgery-video-atlasDominate Surgery: A High-Yield Guide to Your Surgery Clerkship: https://behindtheknife.org/premium/dominate-surgery-a-high-yield-guide-to-your-surgery-clerkshipDominate Surgery for APPs: A High-Yield Guide to Your Surgery Rotation: https://behindtheknife.org/premium/dominate-surgery-for-apps-a-high-yield-guide-to-your-surgery-rotationVascular Surgery Oral Board Review Course: https://behindtheknife.org/premium/vascular-surgery-oral-board-audio-reviewColorectal Surgery Oral Board Review Course: https://behindtheknife.org/premium/colorectal-surgery-oral-board-audio-reviewSurgical Oncology Oral Board Review Course: https://behindtheknife.org/premium/surgical-oncology-oral-board-audio-reviewCardiothoracic Oral Board Review Course: https://behindtheknife.org/premium/cardiothoracic-surgery-oral-board-audio-reviewDownload our App:Apple App Store: https://apps.apple.com/us/app/behind-the-knife/id1672420049Android/Google Play: https://play.google.com/store/apps/details?id=com.btk.app&hl=en_US

I think this Dungeons and Dragons campaign needs a skill check, it's Circulating the Tapes, the MST3K watchalong podcast on The Aewchcast. On this episode,  Aewch thinks Miles O'Keefe put way too many skill points into his pecs, as he reviews Cave Dwellers.Watch Cave Dwellers Right Here!The CTT UERL Top 10! I Accuse My ParentsGodzilla vs MegalonMaster Ninja 1Santa Claus Conquers the MartiansAvalancheWerewolfAngels RevengeThe StarfightersTeenage StranglerMerlin's Shop of Mystical WondersSocial Media: @JustAewch Email: aewch64@gmail.com

Even Lionel Richie thinks this ceiling stuff is boring, it's Circulating the Tapes, the MST3K watchalong podcast on The Aewchcast. On this episode, Aewch only wants to be friends with the moon as he reviews Project Moonbase. Plus, chapters 7 & 8 of the kid-friendly hero Commando Cody in Radar Men From the Moon. “Watch” Project Moonbase ⁠Right Here!⁠The CTT UERL Top 10! ⁠I Accuse My Parents⁠⁠Godzilla vs Megalon⁠⁠Master Ninja 1⁠⁠Santa Claus Conquers the Martians⁠⁠Avalanche⁠⁠Werewolf⁠⁠Angels Revenge⁠⁠The Starfighters⁠⁠Teenage Strangler⁠⁠Merlin's Shop of Mystical Wonders⁠Social Media: ⁠@JustAewch ⁠Email: ⁠aewch64@gmail.com

Even Lionel Richie thinks this ceiling stuff is boring, it's Circulating the Tapes, the MST3K watchalong podcast on The Aewchcast. On this episode, Aewch only wants to be friends with the moon as he reviews Project Moonbase. Plus, chapters 7 & 8 of the kid-friendly hero Commando Cody in Radar Men From the Moon. “Watch” Project Moonbase Right Here!The CTT UERL Top 10! I Accuse My ParentsGodzilla vs MegalonMaster Ninja 1Santa Claus Conquers the MartiansAvalancheWerewolfAngels RevengeThe StarfightersTeenage StranglerMerlin's Shop of Mystical WondersSocial Media: @JustAewch Email: aewch64@gmail.com

Host: Charles Turck, PharmD, BCPS, BCCCP Guest: Petros Grivas, MD, PhD Could emerging biomarkers redefine how we assess response and recurrence risk in muscle-invasive bladder cancer? To find out, Dr. Charles Turck speaks with Dr. Petros Grivas about the key findings from the phase 3 NIAGARA trial. Together, they explore how perioperative durvalumab impacts circulating tumor DNA (ctDNA) clearance and clinical outcomes, including event-free and overall survival. Their conversation also highlights the prognostic value of ctDNA and the potential for urinary tumor DNA to more closely correlate with pathologic complete response. Dr. Grivas is a Professor in the Division of Hematology and Oncology at the University of Washington School of Medicine, as well as the Clinical Research Division at the Fred Hutchinson Cancer Center, where he's also the Medical Director of the International Program and of local and regional outreach.

Circulating your sexual energy might sound a bit out there… but this is one of the most powerful things you can learn as a man.Most guys experience sex as a build-up → release → depletion cycle. A few minutes of pleasure… then it's over, and the energy is gone.But when you learn how to circulate that energy instead of just releasing it, everything changes.You can experience full-body orgasms, sustain arousal without losing control, and actually build energy through sex instead of draining yourself.In this video, I go deep into what it really means to circulate sexual energy — not just the beginner-level “breathe it up and down” stuff, but the deeper principles that actually make this work.In this video you'll learn:• What sexual energy actually is (beyond just arousal)• Why most men feel drained after sex• How to redirect sexual energy through your body• The role of the microcosmic orbit and energy channels• Why force-based techniques don't work long-term• How to develop real sensitivity to your body and energy• The shift from mechanical technique → embodied awarenessGet my FREE Ebook - 3 Techniques for Legendary Ejaculation Control:

Ohh, this just got awkward. It's Circulating the Tapes, the MST3K watchalong podcast on The AewchCast. On this episode, Aewch pulls the ultimate sin: Listening to his own episodes, as he reviews Merlin's Shop of Mystical wonders. Again!Watch Merlin's Shop of Mystical Wonders Right Here!Listen to our previous episode on Merlin Right Here!The CCT UERL Top 10!I Accuse My ParentsGodzilla vs MegalonMaster Ninja 1Santa Claus Conquers the MartiansAvalancheWerewolfAngels RevengeThe StarfightersTeenage StranglerSwamp DiamondsSocial Media: @JustAewch Email: aewch64@gmail.com

In this video, Dr. Ruscio discusses the benefits of glutathione, the body's master antioxidant. He discusses how to boost glutathione naturally via the diet, supplements that help boost glutathione, and how to supplement with glutathione directly (including the best forms and doses of glutathione).   ✅ Start healing with us! Learn more about our virtual clinic:  https://drruscio.com/virtual-clinic/  

In this JCO PO Article Insights episode, host Carolyn Lineen summarizes the article, "Prognostic Significance of Blood-Based Multicancer Detection in Circulating Tumor DNA: Five-Year Outcomes Analysis" bySwanton et al. LINK TO FULL TRANSCRIPT

Hour 2 - The KS Supreme Court will never text message you.

In the final episode of this series, Dr. Justin Abbatemarco and Dr. Shreya Louis discuss the study results and their implications for improving clinical practice.  Read more about this abstract on the AAN website. 

Circulating around the internet right now, is the bold claim that Israel is bombing Christian villages in Lebanon. The insinuation is that Israel is purposely targeting Christians, because Israel has a particular hatred for anything Christian in the Middle East. And as odd as it might sound, it's actually true. At least the bombing part is. The reason though? Very different from what people are claiming. Also it looks like Israel has eliminated 1,800 Hezbollah terrorists in Lebanon, which is incredible.  Justin Hilton Breaks it down for you here on today's show.  Get your Exist t-shirt here: https://israelguys.link/shirt-86ex929qn  Join our Members Group! https://israelguys.link/donate-86ex929h6  Sign up for the Prophets of Israel Daily: https://thelandofisrael.com/prophets-of-israel/ Sign up for The Israel Guys Show Notes: https://theisraelguys.com/subscribe/ Follow The Israel Guys on X: https://x.com/theisraelguys Join our Telegram channel: https://t.me/theisraelguys #Israelnews #Hezbollah #Lebanon #Iranwar #Trump #Bibi #Americannews #Ceasefire  

In part two of this series, Dr. Justin Abbatemarco and Dr. Shreya Louis discuss how this technology was developed and how it has evolved.  Read more about this abstract on the AAN website. 

Featuring an interview with Dr Natalie Vokes, including the following topics: Perioperative minimal residual disease (MRD) detected by circulating tumor DNA (ctDNA) testing in patients with lung cancer (0:00) Ohara S et al. Clinical significance of perioperative MRD detected by ctDNA in patients with lung cancer with a long follow-up data: An exploratory study. JTO Clin Res Rep 2024;6(3):100762. Abstract Masuda K et al. MRDSEEKER (JCOG2111A): A prospective study to evaluate MRD and its association with prognosis in curative-intent NSCLC. World Conference on Lung Cancer 2025;Abstract P3.18.04.  Zhou C et al. IMpower010: Biomarkers of disease-free survival in a phase 3 study of atezolizumab vs best supportive care after adjuvant chemotherapy in stage IB-IIIA NSCLC. ESMO IO 2021;Abstract 2O. MRD analysis of adjuvant therapy with osimertinib for resected EGFR-mutated Stage IB to IIIA non-small cell lung cancer (NSCLC) (8:28) Herbst RS et al. Molecular residual disease analysis of adjuvant osimertinib in resected EGFR-mutated stage IB-IIIA non-small-cell lung cancer. Nat Med 2025;31(6):1958-68. Abstract MRD analyses of perioperative chemoimmunotherapy for resected NSCLC (15:12) Forde PM et al. Overall survival with neoadjuvant nivolumab plus chemotherapy in lung cancer. N Engl J Med 2025;393(8):741-52. Abstract  ctDNA dynamics in advanced NSCLC treated with immunotherapy (20:56) Vokes NI et al. Circulating tumor DNA (ctDNA) dynamics and survival outcomes in patients (pts) with advanced non-small cell lung cancer (aNSCLC) and high (>50%) programmed cell death ligand 1 (PD-L1) expression, randomized to cemiplimab (cemi) vs chemotherapy (chemo). ASCO 2023;Abstract 9022. Anagnostou V et al. ctDNA response after pembrolizumab in non-small cell lung cancer: Phase 2 adaptive trial results. Nat Med 2023;29(10):2559-69. Abstract Anagnostou V et al. A biomarker-directed, multi-center phase II/III study of ctDNA molecular response adaptive immuno-chemotherapy in patients with non-small cell lung cancer (BR.36). ASCO 2025;Abstract TPS8669. CME information and select publications

Dr Natalie Vokes from The University of Texas MD Anderson Cancer Center in Houston discusses recent developments with circulating tumor DNA assays in the management of lung cancer. CME information and select publications here.

In the first part of this series, Dr. Justin Abbatemarco and Dr. Shreya Louis discuss the background and evolving terminology around circulating tumor DNA, cell‑free DNA and CSF‑based testing in neurology.  Read more about this abstract on the AAN website. 

Love doesn't arrive from a distance; it circulates in here. You're attached. You're connected. Help is here. WATCH. LISTEN. READ. KNOW. LOVE.

The “cicada” COVID-19 subvariant is circulating around the country and has made its way to Louisiana. We'll talk about it with Dr. Fred Lopez, Professor of Medicine in the Section of Infectious Diseases at LSU Health New Orleans

* It's the one year anniversary of President Trump's Liberation Day tariffs. We'll break down their impact with Mark Hamrick, a Bankrate senior economic analyst. * The “cicada” COVID-19 subvariant is circulating around the country and has made its way to Louisiana. We'll talk about it with Dr. Fred Lopez from LSU Health New Orleans.

Amy Jacobson, from Together for School Meals, joins IT2 to talk about the petitions that are circulating for signatures to get their measure on November's ballot. Find more info here: https://www.togetherforschoolmeals.org/ See omnystudio.com/listener for privacy information.

Link Up w/The Morning Sickness Digitally All Over:Instagram: @hms_98_official, @bosskupd, @bretvesely, @dickToledoX/Twitter: @HMSon98, @DickToledo, @bretveselyFacebook: @HMSKUPDYouTube: @hmspodcast9320, @98kupdRequest/Call in/Wakeup Song line:(IN AZ) 602.585.9800More HMS: holmbergpodcast.com, 98kupd.comEmail: dtoledo@98kupd.com, bvesely@98kupd.com, bbogen@98kupd.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Link Up w/The Morning Sickness Digitally All Over:Instagram: @hms_98_official, @bosskupd, @bretvesely, @dickToledoX/Twitter: @HMSon98, @DickToledo, @bretveselyFacebook: @HMSKUPDYouTube: @hmspodcast9320, @98kupdRequest/Call in/Wakeup Song line:(IN AZ) 602.585.9800More HMS: holmbergpodcast.com, 98kupd.comEmail: dtoledo@98kupd.com, bvesely@98kupd.com, bbogen@98kupd.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Featuring an interview with Dr Lajos Pusztai, including the following topics: Circulating tumor DNA monitoring for patients with ER-positive, HER2-negative high-risk breast cancer during adjuvant endocrine therapy (0:00) Clinical performance of a whole-genome assay for predicting disease recurrence (5:52) Using circulating tumor DNA status to personalize CDK4/6 inhibitor therapy (12:46) Neoadjuvant and adjuvant therapy stratified by circulating tumor DNA status (21:11) Utility of circulating tumor DNA status in the management of metastatic breast cancer (24:55) CME information and select publications

Dr Lajos Pusztai from Yale Cancer Center in New Haven, Connecticut, discusses recent developments with circulating tumor DNA assays in the management of breast cancer.CME information and select publications here.

Carl and Mike open the show discussing the possible names being linked to the Falcons, especially at receiver, as we near the start of legal tampering.

Linktree: ⁠⁠⁠https://linktr.ee/Analytic⁠⁠⁠Join The Normandy For Ad-Free NME, Additional Bonus Audio And Visual Content For All Things Nme+! Join Here:⁠⁠⁠ ⁠⁠https://ow.ly/msoH50WCu0K⁠⁠⁠ The Notorious Mass Effect segment dives deep into Drake's Iceman era breakdown for February–March 2026. Hosted by Analytic Dreamz, this episode delivers a structured timeline of the rollout for Drake's ninth studio album, Iceman, expected via OVO Sound / Republic Records in 2026.Key highlights include the unverified 24-second "GREATEST" snippet leaked February 7, 2026, via fan account @iilccceeeeman—featuring black-and-white visuals, Drake in a hoodie with OVO/owl imagery, chains, and skeletal hand accessories. Circulating leaks encompass titles like "Secrets," "National Treasure," "Supermax," "Stuck," "What Did I Miss?," "Lake Como," "Spicy Hot," "Plot Twist," "Go Figure," and "Make Them Cry," amid mislabeling issues and the 2025 Bagwork incident involving teenage streamers tied to memecoin promo.Drake's cryptic Instagram Stories promo surged February 20–March 2, 2026, with posts like "ICEMAN IS SO COOL," Japan-themed icy motifs, "it's freezing," "ICEMAN 2026," and "MAKE THEM CRY"—sparking speculation around March 6 or March 20 drops, potential singles, and Episode 4 teases. No official single, tracklist, or tour emerged, but coverage from HotNewHipHop and The Source amplified buzz. Betting markets hovered around 48% for a pre-April release.Analytic Dreamz examines the "Iceman Leak Cycle," controlled leak theories, fan frustration over the "hostage" rollout, subtle disses, OVO tensions, and high engagement despite divided sentiment. As of early March 2026, momentum remains strong in controlled chaos—cryptic marketing mixed with genuine leaks—positioning Iceman as a potential 2026 heavyweight.Tune in for this detailed, fact-driven analysis of Drake's most anticipated era yet.Support this podcast at — https://redcircle.com/analytic-dreamz-notorious-mass-effect/exclusive-contentPrivacy & Opt-Out: https://redcircle.com/privacy

Talk about good head, it's Circulating the Tapes, The MST3K Watchalong Podcast on The Aewchcast. On this episode, Aewch wants to know how does one become a judge for a body contest, as he reviews The Brain That Wouldn't Die.Watch The Brain That Wouldn't Die Right Here!The CTT UERL Top 10!I Accuse My ParentsGodzilla vs MegalonMaster Ninja 1Santa Claus Conquers the MartiansAvalancheWerewolfAngels RevengeThe StarfightersTeenage StranglerSwamp DiamondsSocial Media: @JustAewchEmail: aewch64@gmail.com

Circulating around Facebook: clinicians recommending omitting gluten. Fallacy: It's never recommended to try a gluten free diet before getting tested for Celiac. If a physician recommends it, please ask to get tested for Celiac Disease first.I would love to hear from you! Leave your messages for Andrea at contact@baltimoreglutenfree.com and check out www.baltimoreglutenfree.comInstagramFacebookGluten Free College 101Website: www.glutenfreecollege.comFacebook: http://www.Facebook.com/Glutenfreecollege Hosted on Acast. See acast.com/privacy for more information.

Commentary by Dr.  Jian'an Wang.

On the phone-in: Gardening expert Niki Jabbour is back to answer more listeners' questions. And off the top, we hear about counterfeit cash circulating in the region. Saint John Police and Nova Scotia RCMP are asking shoppers and businesses to be vigilant.

Featuring an interview with Dr Terence Friedlander, including the following topics: Final analysis of the Phase III, open-label, randomized POTOMAC trial (0:00) KEYNOTE-905 trial: Perioperative enfortumab vedotin with pembrolizumab for muscle-invasive bladder cancer (MIBC) (5:25) The neoadjuvant gemcitabine intravesical system TAR-200 for patients with MIBC: Primary analysis of the SunRISe-4 trial (14:07) Circulating tumor DNA-guided therapies for MIBC (18:41) CME information and select publications

It's a lot like the Time Warp, but without the pelvic thrusts, It's Circulating the Tapes, the MST3K Watchalong podcast on The Aewchcast. On this episode, Aewch finds out Terror comes in  a size Petite Medium, as he reviews Terror From the Year 5000. Watch Terror From the Year 5000 Right Here!The CCT UERL Top 10!I Accuse My ParentsGodzilla vs MegalonMaster Ninja 1Santa Claus Conquers the MartiansAvalancheWerewolfAngels RevengeThe StarfightersTeenage StranglerSwamp DiamondsSocial Media: @JustAewchEmail: aewch64@gmail.com

Guest: Padraic Scanlan. Scanlan details the volatility in the Irish countryside, the use of coercion acts, and the lack of circulating cash as evidence of uncivilization.1847 EIRE

Giannis might be the big prize out there as it seems like his time in Milwaukee is coming to an end but what other rumors are out there and will the Celtics use Anfernee Simons to improve the team. #nbatraderumors #giannis #giannistrade #knicks #nba #nbanews #anfreneesimons #bostonceltics #karlanthonytowns #espn

In this JCO Precision Oncology Article Insights episode, host Dr. Jiasen He summaries the article, "Longitudinal Evaluation of Circulating Tumor DNA as a Prognostic Biomarker to Detect Molecular Residual Disease in Germ Cell Tumors," by Hassoun et al. TRANSCRIPT Jiasen He: Hello, and welcome to the JCO Precision Oncology Article Insights. I'm your host, Jiasen He, and today, we'll be discussing the JCO Precision Oncology article, "Longitudinal Evaluation of Circulating Tumor DNA as a Prognostic Biomarker to Detect Molecular Residual Disease in Germ Cell Tumors," by Dr. Rebecca Hassoun and colleagues. Traditionally, treatment response for solid tumors has relied on imaging, which focuses on visible anatomic changes in the tumor. However, imaging does not always reflect molecular or cellular changes and cannot detect microscopic disease, which is clinically important and often linked to relapse. Liquid biopsy, on the other hand, is minimally invasive and can be used for cancer monitoring by analyzing circulating biomarkers in biofluids such as blood. One type of liquid biopsy is circulating tumor DNA, or ctDNA, which measures small fragments of DNA released by tumor cells into the bloodstream. ctDNA can allow precise monitoring of tumor-specific mutations and be a powerful tool for assessing treatment responses. ctDNA has already been applied in clinical settings for cancers such as non-small cell lung cancer and breast cancer, etcetera. However, there is still limited data on the use of ctDNA for germ cell tumors. Germ cell tumors are the most common malignancy affecting men aged 15 to 35 years. Accurate risk stratification and disease monitoring is key to risk-adapted therapy, maximizing the chance of cure while minimizing side effects. One unique tool we use currently for diagnosis, staging, and monitoring is serum tumor markers, such as AFP, beta-hCG, and LDH. However, these markers have limitations, including false elevation in certain clinical scenarios, and studies have shown that they can be normal in up to 40 percent of patients with germ cell tumor. This creates an unmet need for other sensitive and specific biomarkers to improve patient care. In this paper, the authors investigated the use of ctDNA in a cohort of patients with germ cell tumor at various disease time points. They compared ctDNA results with traditional serum tumor markers to evaluate whether ctDNA can predict relapse and survival outcomes. This multi-institutional retrospective study included patients with stage I, II, and III germ cell tumors, primarily testicular cancer, who had at least one ctDNA test result. ctDNA was evaluated longitudinally at different time points, including pre-orchiectomy, during the molecular residual disease, or MRD, window, defined as 1 to 12 weeks post-orchiectomy but before primary therapy, and during the surveillance window, defined as more than 12 weeks post-orchiectomy or follow retroperitoneal lymph node dissection or post-chemotherapy. ctDNA analysis was performed using a tumor-informed 16 multiplex PCR next-generation sequencing assay. A total of 324 plasma samples were analyzed from 74 patients in this cohort. The majority had stage I disease, around 40 percent, and nonseminomatous histology, around 70 percent. 15 patients were evaluated in the pre-orchiectomy window, and only one patient tested negative for ctDNA. This patient had stage I disease. The authors further assessed ctDNA positivity in both the MRD window and surveillance window, evaluating its association with event-free survival. They found that ctDNA outperformed serum tumor markers in both settings. ctDNA positivity was associated with significantly worse event-free survival compared with ctDNA-negative patients. Among the 14 patients with stage II to III disease who had ctDNA assessed in both the MRD window and surveillance window, nine patients consistently had a negative ctDNA or converted from positive to negative over time. In contrast, five patients demonstrated persistent ctDNA positivity, and all of these patients subsequently relapsed. Among the 38 patients who had both ctDNA and serum tumor marker tests during the MRD window, nine patients showed discordant biomarker results. Of these, 6 patients were ctDNA-negative but serum tumor marker-positive, and one of them experienced recurrence. Three patients were ctDNA-positive but serum tumor marker-negative, and one of these patients also recurred. During the surveillance window, 46 patients had both biomarkers available, and 10 showed discordant results. Three patients were ctDNA-negative but serum tumor marker-positive, and none of them recurred. In contrast, all seven patients who were ctDNA-positive but serum tumor marker-negative experienced recurrence. This intriguing data strongly support the potential role of ctDNA in patients with stage I, II, and III germ cell tumors. However, as the authors noted, the retrospective nature of the study presents limitations, as treatment approaches, imaging schedules, and the timing of testing were not standardized, and ctDNA testing varies among participating institutions. Larger prospective trials with standardized protocols and long-term follow-up will be essential to validate these findings and determine how ctDNA can be reliably integrated into clinical practice. Thank you for tuning in to JCO Precision Oncology Article Insights. Don't forget to subscribe and join us next time as we explore more groundbreaking research shaping the future of oncology. The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions.  Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement.

A murder for hire case touted by the Department of Homeland Security falls apart at trial. The AP's Jennifer King reports.

Featuring an interview with Dr Scott Kopetz, including the following topics:  Circulating tumor DNA (ctDNA)-guided adjuvant chemotherapy de-escalation in the treatment of Stage III colon cancer from the ctDNA-negative cohort of the DYNAMIC-III trial (0:00) Prognostic and predictive role of ctDNA in the management of Stage III colon cancer treated with celecoxib: Findings from the CALGB (Alliance)/SWOG 80702 trial (8:01) Phase III ALTAIR study comparing trifluridine/tipiracil to placebo for patients with molecular residual disease after curative resection of colorectal cancer (CRC); a methylation-based, tissue-free ctDNA test (12:51) ctDNA with locally advanced mismatch repair-deficient/microsatellite instability-high solid tumors; real-world evidence regarding ctDNA with resected CRC (17:31) CME information and select publications

Dr Scott Kopetz from The University of Texas MD Anderson Cancer Center in Houston discusses recent developments with circulating tumor DNA assays in the management of colorectal cancer. CME information and select publications here.

Dr Scott Kopetz from The University of Texas MD Anderson Cancer Center in Houston discusses recent developments with circulating tumor DNA assays in the management of colorectal cancer. CME information and select publications here.

Featuring an interview with Dr Scott Kopetz, including the following topics: Circulating tumor DNA (ctDNA)-based molecular residual disease (MRD) and survival among patients with resectable colorectal cancer (CRC) in the CIRCULATE-Japan GALAXY trial (0:00) ctDNA for detection of MRD in patients with CRC in the BESPOKE CRC and INTERCEPT trials (3:11) Clinical utility of including ctDNA monitoring in standard CRC surveillance (11:11) ctDNA analysis guiding adjuvant therapy for CRC in the DYNAMIC and CIRCULATE-North America trials (15:52) CME information and select publications

Dr Scott Kopetz from The University of Texas MD Anderson Cancer Center in Houston discusses recent developments with circulating tumor DNA assays in the management of colorectal cancer.CME information and select publications here.

Dr Scott Kopetz from The University of Texas MD Anderson Cancer Center in Houston discusses recent developments with circulating tumor DNA assays in the management of colorectal cancer.CME information and select publications here.

A new version of the common flu is spreading globally, and health officials are monitoring this evolving strain of influenza A which has been increasingly detected worldwide. In other news, It's official: McKinney National Airport has its first airline. Avelo Airlines, the Houston-based budget carrier, signed a five-year use and lease agreement, the airport said Tuesday evening; Dallas Mavericks owner and casino magnate Miriam Adelson urged President Donald Trump to run for a third term in 2028; nd Romeo Santos and Prince Royce will perform together for the first time in Dallas next spring as part of their “Mejor Tarde Que Nunca” tour. In Dallas, they will perform on Saturday, May 9, at American Airlines Center. Tickets go on sale this Friday, Dec. 19. Learn more about your ad choices. Visit podcastchoices.com/adchoices

(SPOILER) Your Daily Roundup covers Taylor Frankie Paul's final week of filming, the Blake Moynes story circulating, tomorrow's live re-watch on the Patreon channel, & Rob Reiner's directorial run from the mid 80's to early 90's.    Music written by Jimmer Podrasky (B'Jingo Songs/Machia Music/Bug Music BMI) Ads: ZocDoc – Click on https://zocdoc.com/RealitySteve to find and instantly book a top rated doctor today.  Learn more about your ad choices. Visit megaphone.fm/adchoicesSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

(SPOILER) Your Daily Roundup covers Taylor Frankie Paul's final week of filming, the Blake Moynes story circulating, tomorrow's live re-watch on the Patreon channel, & Rob Reiner's directorial run from the mid 80's to early 90's.    Music written by Jimmer Podrasky (B'Jingo Songs/Machia Music/Bug Music BMI) Ads: ZocDoc – Click on https://zocdoc.com/RealitySteve to find and instantly book a top rated doctor today.  Learn more about your ad choices. Visit megaphone.fm/adchoices

Former high-school teacher turned hypnotherapist, DJ, and three-time spiritual entrepreneur, Anna Cantwell shares how she went from burnout and "can't-pay-rent" panic to making great money doing work she loves—by prioritizing receiving, play, and ease. We dig into Hot Money Summer–style prompts, why compliments are cash practice, and practical ways to circulate stuck energy so abundance can find you. In this conversation From broke, sick, and overworked to six figures in 15 hours/week—what changed (and what didn't). Why "hard work = money" breaks down—and the feminine side of receiving. The Zone of Proximal Development for money mentors (learning from someone just ahead of you). Fun, fast exercises: "Hot Money Bummers → Wouldn't It Be Nice…," playful income reframes, and saying "thank you, I receive that." Circulating energy: clothing swaps, donating, and finding the money you forgot you had. Book sneak peek: Abundance Mindset Magic—the fun, feminine & magical way to manifest money and open yourself to receive. Try-it-now prompts Compliment practice: For 7 days reply, "Thank you—I receive that." Notice what shifts. Reframe your income: Write the funnest way to describe how you currently make money—and one way you'd love to. Clear & circulate: Unused items → swap/donate to create space for new inflow.  Connect with Anna Book: Abundance Mindset Magic (available via major booksellers). IG: @iamannacantwell Connect with Jen Join the Manifestation Playground Instagram → @manifestationandmoneypodcast Cheers to creating a life you love!

Brock and Salk talk through the elements of what makes a team a Super Bowl team and how much of it the Seahawks have on their roster. They then look at a handful of names that the Mariners could trade for, especially with the MLB Winter Meetings coming up next week. In Blue 88, Brock analyzes more on the Seahawks culture, Mike Macdonald discussing the Vikings defense and the University of Colorado athletic department.

Send us a textHow mitochondria travel between cells and how this hidden communication shapes metabolism, immunity, and even potential therapies.Episode Summary: Dr. Jon Brestoff talks about mitochondrial dynamics inside cells, their transfer between unrelated cells (distinct from inheritance during division), and its roles in adipose tissue communication, macrophage cleanup, and systemic metabolic signaling; they explore how high-fat diets disrupt this process, potential hormetic benefits, therapeutic mitochondria transplantation for diseases like Leigh syndrome and obesity, and broader immunometabolism crosstalk.About the guest: Jon Brestoff, MD, PhD is an associate professor of pathology and immunology at Washington University School of Medicine in St. Louis, where he directs the Initiative for Immunometabolism.Discussion Points:Mitochondria per cell range from ~100-5000; they move via fusion/fission, vertical inheritance (cell division), or horizontal transfer without division.Transfer mechanisms: free release, extracellular vesicles, or tunneling nanotubes using cytoskeleton transport.In healthy fat tissue, adipocytes routinely donate mitochondria to macrophages for degradation (quality control); high-fat (lard-based, long-chain FA) diets block macrophage uptake, diverting mitochondria to other organs.Diverted mitochondria may induce “mito-hormesis” (mild oxidative stress boosting antioxidants) or signal adipocyte metabolic status inter-organ.Mitochondria transplantation shows promise in animal models for ischemia-reperfusion, obesity, and mitochondrial diseases.Immune cells prefer glycolysis but have low mitochondrial biomass; transplanted mitochondria tilt T-cells toward anti-inflammatory regulatory phenotype.Circulating cell-free mitochondria rival immune cell numbers.Obesity inflammation stems from dying oversized adipocytes releasing lipids/mitochondria, forming crown-like structures with pro-inflammatory macrophages.Leigh syndrome from genetic mutations disrupting the electron transport chain.Transfer may be an evolutionary relic of endosymbiosis; cells may selectively use exogenous mitochondria like a “generator” during metabolic crisis.Reference Paper:Study: The power and potential of mitochondria transferRelated Episode:M&M 260: Energy Resistance Principle in Life, Healing & Disease | Martin Picard & Nirosha MuruganSupport the showAffiliates: Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they're hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Code MIND for 10% off SiPhox Health—Affordable at-home blood testing. Key health markers, visualized & explained. Code TRIKOMES for a 20% discount. For all the ways you can support my efforts