Podcasts about prospective study

Join Dr. Clancy and guest Katey Kooi for a discussion of the benefits of music therapy in palliative and end-of-life care. CME Credit Available:  https://uiowa.cloud-cme.com/course/courseoverview?P=0&EID=72842  Host: Gerard Clancy, MD Senior Associate Dean for External Affairs Professor of Psychiatry and Emergency Medicine University of Iowa Carver College of Medicine Guest: Katey Kooi, MT-BC Music Therapist, Supportive and Palliative Care University of Iowa Health Care Financial Disclosures:  Dr. Clancy, Ms. Kooi, and the members of the Rounding@IOWA planning committee have disclosed no relevant financial relationships. Nurse: The University of Iowa Roy J. and Lucille A. Carver College of Medicine designates this activity for a maximum of 1.0 ANCC contact hour. Pharmacist and Pharmacy Tech: The University of Iowa Roy J. and Lucille A. Carver College of Medicine designates this knowledge-based activity for a maximum of 1.0 ACPE contact hours. Credit will be uploaded to the NABP CPE Monitor within 60 days after the activity completion. Pharmacists must provide their NABP ID and DOB (MMDD) to receive credit. Pharmacist UAN: JA0000310-0000-25-039-H99-P Pharmacy Tech UAN: JA0000310-0000-25-039-H99-T Physician: The University of Iowa Roy J. and Lucille A. Carver College of Medicine designates this enduring material for a maximum of 1.0 AMA PRA Category 1 CreditTM. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Other Health Care Providers: A certificate of completion will be available after successful completion of the course. (It is the responsibility of licensees to determine if this continuing education activity meets the requirements of their professional licensure board.) References/Resources:  Gutgsell, Kathy Jo et al. (2013) Music Therapy Reduces Pain in Palliative Care Patients: A Randomized Controlled Trial. Journal of Pain and Symptom Management, Volume 45, Issue 5, 822 – 831. Gallagher, Ragman, Rybicki. (2018) Outcomes of Music Therapy Interventions on Symptom Management in Palliative care patients. American Journal of Hospice and Palliative Medicine Vol 35(2) 250-257. Hilliard R. E. (2003). The effects of music therapy on the quality and length of life of people diagnosed with terminal cancer. Journal of music therapy, 40(2), 113–137. https://doi.org/10.1093/jmt/40.2.113 Bradt J, Dileo C, Grocke D, Magill L. (2011) Music interventions for improving psychological and physical outcomes in cancer patients.Cochrane Database Syst Rev. Aug 10;(8) Ramesh B. (2024) Role of Music Therapy in Palliative Care—Methods and Techniques. Journal of Palliative Care. https://journals.sagepub.com/doi/10.1177/08258597241235110 Whitford, Kevin J. et al.Music Therapy Intervention to Reduce Caregiver Distress at End of Life: A Feasibility Study Journal of Pain and Symptom Management, Volume 65, Issue 5, e417 - e423 https://www.jpsmjournal.com/article/S0885-3924(23)00035-0/fulltext Sarah Kordovan, Pia Preissler, Anne Kamphausen, Carsten Bokemeyer, and Karin Oechsle. (2016)Prospective Study on Music Therapy in Terminally Ill Cancer Patients during Specialized Inpatient Palliative Care Journal of Palliative Medicine  19:4, 394-399. Lopez, G., Christie, A.J., Powers-James, C. et al. (2019). The effects of inpatient music therapy on self-reported symptoms at an academic cancer center: a preliminary report. Support Care Cancer 27, 4207–4212. https://doi.org/10.1007/s00520-019-04713-4 Brungardt A, Wibben A, Tompkins AF, Shanbhag P, Coats H, LaGasse AB, Boeldt D, Youngwerth J, Kutner JS, Lum HD.(2021) Virtual Reality-Based Music Therapy in Palliative Care: A Pilot Implementation Trial. J Palliat Med. May;24(5):736-742. Ghetti, C. M., Schreck, B., & Bennett, J. (2023). Heartbeat recordings in music therapy bereavement care following suicide: Action research single case study of amplified cardiopulmonary recordings for continuity of care. Action Research, 0(0). https://doi.org/10.1177/14767503231207993  

In this episode of RAPM Focus, Editor-in-Chief Brian Sites, MD, is thrilled to welcome Kesavan Sadacharam, MD, and Allison Fernandez, MD, following the April 2024 publication of their original research paper, “Multisite prospective study of perioperative pain management practices for anterior cruciate ligament reconstruction in adolescents: Society for Pediatric Anesthesia Improvement Network (SPAIN) Project Report.” Unwarranted variation in health care refers to differences in health care delivery that cannot be attributed to patient illness, medical evidence, or patient preferences. Instead, these variations arise from differing local medical practices, resource availability, and physician decision-making processes. Unwarranted variations can lead to sub-optimal patient outcomes, with some patients receiving unnecessary or harmful treatments while others may not receive beneficial interventions. Two individuals are behind a multi-center collaborative initiative that looks at the utilization of regional anesthesia and pain medicine techniques for ACL reconstruction. Dr. Allison Fernandez is an associate professor at Johns Hopkins All Children's Hospital, practicing pediatric anesthesia, and pediatric acute and chronic pain management. Dr. Fernandez started a video series, Women of Impact in Anesthesia, empowering women in medicine. Dr. Kesavan Sadacharam is a pediatric anesthesiologist and associate professor at Nemours Children's Health, located in Wilmington, DE. He is currently the director of regional anesthesia and practices both acute and chronic pain management. *The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice, and it is not intended to function as a substitute for a healthcare practitioner's judgement, patient care, or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others. Podcast and music produced by Dan Langa. Find us on X @RAPMOnline, Facebook @Regional Anesthesia & Pain Medicine, and Instagram @RAPM_Online.

In an analysis of patients undergoing kidney transplantation, depression and health related quality of life were measured at 3-months and 1-year post-transplantation. Depression and HRQOL improve with KT.

Commentary by Dr. Candice Silversides

In this episode, Dr. Tarik Kani  interviews Dr Milou van Riswijk from The Netherlands about a new bowel cleansing system which was designed to overcome an important issue for endoscopists and patients.

Dr. Halley Alexander discusses the Neurology Today article, "Prospective Study Presents Longitudinal Trajectory of Cognitive Impairment in Patients With Essential Tremor" by Susan Kreimer, available in the June 20th issue of Neurology Today or at neurologytoday.com.  Show reference:  https://journals.lww.com/neurotodayonline/fulltext/2024/06200/prospective_study_presents_longitudinal_trajectory.2.aspx This podcast is sponsored by argenx. Visit www.vyvgarthcp.com for more information.

Dr. Kevin Biese gave a talk at the 2024 Wisconsin Atheltic Trainers Association annual meeting on sports specialization and the evolution of the definition and what current and future research is showing about it. The talk was extremely informational and we wanted to share it on the podcast, thankfully, Kevin was more than willing. In this episode, Dr. Biese dives in deep into what sports specialization is and what the current working definition is. I, personally, was surprised at the definition because it doesn't always only have to be about one sport and the focus on that one exclusively. Dr. Biese has some great general recommendations on how you can help ensure children don't overdo it and also on conversations you can have with student-athletes as an athletic trainer to help them figure out if they are speicalizating and how it could relate to any aches and pains or changes in performance they have. So much to take away from this one. Enjoy.  Extra resources shared by Dr. Biese below. In This Episode: +Defining sports specialization, how multiple sports fit in +How the word ‘restrict' fit in +Risks of sport specialization: injury risk, burnout +Socio-economic impact on sports specialization +Sports activity amount, age=hrs/week of organized sport Connect with Kevin @: biesek@uwosh.edu LIINK: SPIRL Lab (LINK: https://www.uwosh.edu/kinesiology/spirl/ )  FB: https://www.facebook.com/profile.php?id=100068354149116  Other LINKS: Injury risk factors related to sport specialization in high school basketball: a prospective study. | Journal of Athletic Training (allenpress.com) A Prospective Study on the Effect of Sport Specialization on Lower Extremity Injury Rates in High School Athletes - Timothy A. McGuine, Eric G. Post, Scott J. Hetzel, M. Alison Brooks, Stephanie Trigsted, David R. Bell, 2017 (sagepub.com) Comparing Burnout in Sport-Specializing Versus Sport-Sampling Adolescent Athletes: A Systematic Review and Meta-analysis - Nicolas E. Giusti, Seth L. Carder, Lisa Vopat, Jordan Baker, Armin Tarakemeh, Bryan Vopat, Mary K. Mulcahey, 2020 (sagepub.com) Sport Specialization and Sport Motivation in Middle School–Aged Athletes | Journal of Athletic Training (allenpress.com) Sport Specialization and Risk of Overuse Injuries: A Systematic Review With Meta-analysis | Pediatrics | American Academy of Pediatrics (aap.org) Consensus Definition of Sport Specialization in Youth Athletes Using a Delphi Approach | Journal of Athletic Training (allenpress.com) Sport Performance & Injury Research Laboratory - Kinesiology and Athletic Training University of Wisconsin Oshkosh (uwosh.edu) LINK: https://www.athletictrainingchat.com/2024/06/ep-170-dr-kevin-biese-sport.html  www.athletictrainingchat.com www.cliniallypressed.org  SUBSCRIBE: https://www.youtube.com/channel/UCc3WyCs2lmnKK6shrL5A4hw?sub_confirmation=1  #ATCchat #ATtwitter #complicatedsimple #atimpact #at4all #nata #boc #bocatc #athletictraining #athletictrainingchat #health #medicine #medical #careeverywhere --- Support this podcast: https://podcasters.spotify.com/pod/show/athletictrainingchat/support

Circulating tumor DNA, more commonly referred to as ctDNA, has emerged as an attractive and potentially highly sensitive biomarker for patients with colorectal cancer. But what exactly is ctDNA, does it have any prognostic value for patients with colorectal liver metastasis, and how can it be incorporated into the management of said patients? In this episode from the HPB team at Behind the Knife, listen in on the discussion about ctDNA and its role in the perioperative management of colorectal liver metastasis.   Hosts Anish J. Jain MD (@anishjayjain) is a T32 Research Fellow at the University of Texas MD Anderson Cancer Center within the Department of Surgical Oncology. Timothy E. Newhook MD, FACS (@timnewhook19) is an Assistant Professor within the Department of Surgical Oncology. He is also the associate program director of the HPB fellowship at the University of Texas MD Anderson Cancer Center.  Jean-Nicolas Vauthey MD, FACS (@VautheyMD) is Professor of Surgery and Chief of the HPB Section, as well as the Dallas/Fort Worth Living Legend Chair of Cancer Research in the Department of Surgical Oncology at The University of Texas MD Anderson Cancer Center Learning Objectives: -Develop an understanding of what circulating tumor DNA (ctDNA) is.  -Develop an understanding of what makes ctDNA unique from other “tumor markers” like CEA. -Develop an understanding of the prognostic value of ctDNA for colorectal liver metastasis (CRLM).  -Develop an understanding of the current role of ctDNA in the perioperative treatment of patients with CRLM. -Develop an understanding of how ctDNA can be incorporated into future treatment algorithms for patients undergoing hepatic resection for CRLM. Papers Referenced (in the order they were mentioned in the episode): 1)    Newhook TE, Overman MJ, Chun YS, et al. Prospective Study of Perioperative Circulating Tumor DNA Dynamics in Patients Undergoing Hepatectomy for Colorectal Liver Metastases. Ann Surg. 2023;277(5):813-820. https://pubmed.ncbi.nlm.nih.gov/35797554/ 2)    Nishioka Y, Chun YS, Overman MJ, et al. Effect of Co-mutation of RAS and TP53 on Postoperative ctDNA Detection and Early Recurrence after Hepatectomy for Colorectal Liver Metastases. J Am Coll Surg. 2022;234(4):474-483. https://pubmed.ncbi.nlm.nih.gov/35290266/ Please visit https://behindtheknife.org to access other high-yield surgical education podcasts, videos and more.   If you liked this episode, check out our recent episodes here: https://app.behindtheknife.org/listen

At AOFAS Annual Meeting 2023 in Louisville, Kentucky, host Nicholas Strasser, MD, discusses with Jitendra Mangwani, MBBS, MS(Orth), FRCS(Tr&Orth), the IFFAS Award Finalist paper “UK Foot and Ankle Thrombo-Embolism Audit (UK-FATE) – A multicentre prospective study of Venous Thromboembolism in Foot and Ankle Surgery.” To claim CME credit, click here or listen in the free ConveyMED app: Apple Store or Google Play   CME credit is free to AOFAS members and $25 for non-members. 

Commentary by Dr. Candice Silversides

Editor-in-Chief, Robert Amdur, MD, reviews the evidence for treating Low-Intermediate Risk prostate cancer with Ultra Hypofractionated SBRT. This discussion was stimulated by a paper published in the November/December 2023 issue of PRO titled “Long-Term Outcomes of a Prospective Study on Highly Hypofractionated Intensity Modulated Radiation Therapy for Localized Prostate Cancer for 3 Weeks” with PMID 37414247. However, the majority of the podcast will focus on data supporting 5 Fraction SBRT, including the most recent report from the PACE-B trial (Abstract only from the 2023 ASTRO annual Meeting).

The most well done study on saturated fat increasing insulin resistance. This was a prospective cohort study. Also discussed Shawn Baker, Paul Saladino, Carnivore, Keto, and other diets. How to do them correctly without increasing your risk. https://dralo.net/links

Commentary by Dr. Brandon Blue

Dr Henry Ellis from TSRH joins the show to discuss his research on the functional outcomes of open vs. arthroscopic cam resection. Highlights from the lightning round include the impacts of seemingly benign parts of care like saw blades/Dermabond/Pavlik harnesses, the recovery process after femoral flex nails, and more. Your hosts are Carter Clement from Children's Hospital of New Orleans, Julia Sanders from Children's Hospital Colorado, Craig Louer from Vanderbilt, and Josh Holt from University of Iowa. This episode is sponsored by Nuvasive. Music by A. A. Alto.   Citations for papers discussed:   1) Morris et al. Comparison of Gait and Functional Outcomes between Arthroscopic and Open Treatment of Adolescent and Young Adult Femoroacetabular Impingement. JPO E-pub Oct 2023. https://pubmed.ncbi.nlm.nih.gov/37791636/   2) Koritz et al. Incidence of Skin Sensitivity Following Dermabond Application in Pediatric Orthopaedic Surgery. JPO E-pub Oct 2023. https://pubmed.ncbi.nlm.nih.gov/37820062/   3) Gettleman et al. Use of Surgical Adjuvants does not Decrease Recurrence of Aneurysmal Bone Cysts in Surgical Intervention with Pediatric Patients. JPO E-pub Oct 2023. https://pubmed.ncbi.nlm.nih.gov/37815299/   4) Greenhill et al. Metaphyseal Fracture Displacement is Predictive of Intra-articular Diastasis in Adolescent Triplane Ankle Fractures. JPO E-pub Oct 2023. https://pubmed.ncbi.nlm.nih.gov/37779308/   5) Batley et al. What are the Psychosocial Effects of Pavlik Harness Treatment? A Prospective Study on Perceived Impact on Families and Maternal-Infant Bonding. JPO E-pub Oct 2023. https://pubmed.ncbi.nlm.nih.gov/37807604/   6) Stevens et al. Coated Cast Saw Blades Decrease Temperature During Cast Removal. JPO E-pub Oct 2023. https://pubmed.ncbi.nlm.nih.gov/37796155/   7) Flinck et al. Recovery of Gait in Children and Adolescents after Pediatric Femoral Shaft Fracture treated with Intramedullary Nail Fixation: a Longitudinal Prospective Study. JPO E-pub Oct 2023. https://pubmed.ncbi.nlm.nih.gov/37791633/  

What does the body of evidence say on age-related macular degeneration (AMD) and how to treat the #1 cause of blindness in North America? Plus: which vaccines are available this fall to prevent respiratory tract infections, and a look at whether blue-light-blocking glasses will make a difference in your life! Block 1: (2:15) AMD: how common it is, what happens in the eye, risk factors Block 2: (9:20) AMD: dry AMD versus wet AMD, how to diagnose it, how to prevent it, AREDS supplements, VEGF inhibitors, lasers, rehabilitation Block 3: (25:54) Fall vaccines: COVID, influenza, and RSV Block 4: (40:19) Blue-blocking glasses   * Theme music: “Fall of the Ocean Queen“ by Joseph Hackl * Assistant researchers: Aigul Zaripova and Ali Baghirov To contribute to The Body of Evidence, go to our Patreon page at: http://www.patreon.com/thebodyofevidence/. To make a one-time donation to our show, you can now use PayPal! https://www.paypal.com/donate?hosted_button_id=9QZET78JZWCZE Patrons get a bonus show on Patreon called “Digressions”! Check it out!   References: 1) General background on AMD: https://www.nei.nih.gov/learn-about-eye-health/eye-conditions-and-diseases/age-related-macular-degeneration & https://www.aao.org/eye-health/diseases/amd-macular-degeneration 2) Prevalence of AMD by age: https://www.sciencedirect.com/science/article/abs/pii/S0161642000005807 3) Rotterdam study: https://doi.org/10.1001/jama.294.24.3101 4) EYE-RISK consortium about the Mediterranean diet: https://doi.org/10.1016/j.ophtha.2018.08.006 5) The Beaver Dam Eye Study on smoking and AMD: https://doi.org/10.1016/j.ophtha.2014.04.040 6) A Prospective Study of Cigarette Smoking and AMD in Women: https://jamanetwork.com/journals/jama/article-abstract/409082 7) AREDS study: https://doi.org/10.1001%2Farchopht.119.10.1417 8) AREDS 2 study: https://jamanetwork.com/journals/jama/fullarticle/1684847 9) Study linking beta-carotene to cancer in smokers: https://doi.org/10.1093/ajcn/62.6.1427s 10) Omega-3s in the VITAL study: https://jamanetwork.com/journals/jamaophthalmology/fullarticle/2772366 11) Background on anti-VEGF therapies: https://sciencebasedmedicine.org/anti-vegf-treatment-of-macular-degeneration-science-based-success/ 12) NEJM paper comparing ranibizumab to bevacizumab: https://doi.org/10.1056/NEJMoa1102673 13) 10-year outcomes of anti-VEGF therapy in AMD: https://doi.org/10.1136/bmjophth-2023-001328 14) Cochrane review of monthly versus as-needed treatment: https://doi.org/10.1002/14651858.CD012208.pub2 15) Cochrane review on complement inhibitors for AMD: https://doi.org/10.1002/14651858.cd009300.pub3 16) Pegcetacoplan for AMD: https://sciencebasedmedicine.org/pegcetacoplan-a-new-treatment-for-macular-degeneration/ 17) Cochrane review on photodynamic therapy for AMD: https://doi.org/10.1002/14651858.CD002030.pub3 18) Stem cells for AMD: https://www.nejm.org/doi/full/10.1056/NEJMoa1609583 & https://www.washingtonpost.com/national/health-science/this-clinics-experimental-stem-cell-treatment-blinded-patients-four-years-later-the-government-is-still-trying-to-shut-it-down/2019/04/03/432d6d04-ff2f-11e8-83c0-b06139e540e5_story.html & https://sciencebasedmedicine.org/patients-blinded-by-stem-cells-update/ 19) Jonathan's article on blue-blocking glasses: https://www.mcgill.ca/oss/article/medical-critical-thinking/feeling-blue-about-evidence-blue-blocking-glasses   It's Not Twitter, But It'll Do: 1) Jonathan's article on current trends in pseudoscience: https://www.mcgill.ca/oss/article/critical-thinking-pseudoscience/whats-trending-world-pseudoscience 2) Jonathan quoted in the New York Times about RFK Jr.: https://www.nytimes.com/2023/09/12/technology/rfk-jr-campaign-vaccines.html 3) Annual meeting of the Association des communicateurs scientifiques du Québec: https://www.acs.qc.ca/activite/2171-.html?month=&year=&tri=H&page=1 4) Chris' book, on sale now: http://doescoffeecausecancer.com/ 5) Chris' upcoming panel at Concordia University: https://icare.mbmc-cmcm.ca/events-media-coverage/cafe-scientifique/

Dr. Ralph W. Moss and his son Ben dive into the multifaceted world of the avocado. This superfood, known for its creamy texture and health benefits, has recently been at the center of some unexpected scientific findings. While it offers undeniable health advantages for many, there might be potential concerns for others. Join them as they explore the data, breaking down its implications, and help you determine what this means for you or your loved ones. Articles Cited in this Episode: Associations of whole-blood fatty acids and dietary intakes with prostate cancer in Jamaica. Cancer Causes Control. https://pubmed.ncbi.nlm.nih.gov/21984307/ Prospective Study of Avocado Consumption and Cancer Risk in U.S. Men and Women. https://pubmed.ncbi.nlm.nih.gov/36490225/ “A comprehensive self-help plan for cancer includes medicinal mushrooms. They are indispensable”. – Ralph W. Moss, PhD Recommended Product: 5 Defenders Mushroom Blend https://shop.realmushrooms.com/products/organic-mushroom-blend-capsules?ref=391 For more information on cancer-fighting foods and supplements, please visit our website: https://www.themossreport.com Thanks for listening!

Featuring guest Dr. Michelle Loy, this week we're talking all things Integrative Medicine and the role of nutrition in overall health and wellbeing.     References: Twohig-Bennett C, Jones A. The health benefits of the great outdoors: A systematic review and meta-analysis of greenspace exposure and health outcomes. Environ Res. 2018 Oct;166:628-637. doi: 10.1016/j.envres.2018.06.030. Epub 2018 Jul 5. PMID: 29982151; PMCID: PMC6562165.   Michelle Loy. Clinician Wellness—Self-Care for Staying Healthy: Narrative Medicine for Optimizing Well-Being and as an Antidote to Stress and Burnout.Integrative and Complementary Therapies.Aug 2022.163- 165.http://doi.org/10.1089/ict.2022.29027.mlo Pub-lished in Volume: 28 Issue 4: August 17, 2022    Puma J. Culinary Medicine and Nature: Foods That Work Together. Am J Lifestyle Med. 2020;14(2):143-146. Published 2020 Jan 7. doi:10.1177/1559827619895149   Michelle H. Loy, John Usseglio, Danielle Lasalandra, and Melanie A. Gold.Probiotic Use in Children and Adolescents with Overweight or Obesity: A Scoping Review.Childhood Obesity.ahead of print http://doi.org/10.1089/chi.2022.0059 Online Ahead of Print:June 20, 2022   Alejandra Ríos-Hernández, José A. Alda, Andreu Farran-Codina, Estrella Ferreira-García, Maria Izquierdo-Pulido; The Mediterranean Diet and ADHD in Children and Adolescents. Pediatrics February 2017; 139 (2): e20162027. 10.1542/peds.2016-2027   Sílvia Fernández Barrés, Dora Romaguera, Damaskini Valvi, David Martínez, Victoria Arija, Jordi Sunyer, Martine Vrijheid, Mediterranean Dietary Pattern in Pregnant Women and Offspring Risk of Overweight and Abdominal Obesity in Early Childhood: The INMA Cohort Study, Advances in Nutrition, Volume 7, Issue 1, January 2016, Page 34A, https://doi.org/10.1093/advances/7.1.34A   Velázquez-López L, Santiago-Díaz G, Nava-Hernández J, Muñoz-Torres AV, Medina-Bravo P, Torres-Tamayo M. Mediterranean-style diet reduces metabolic syndrome components in obese children and adolescents with obesity. BMC Pediatr. 2014;14:175    Chatzi L, Apostolaki G, Bibakis I, et al. Protective effect of fruits, vegetables and the Mediterranean diet on asthma and allergies among children in Crete. Thorax. 2007;62(8):677–683 123. Cepeda AM, Del Giacco SR, Villalba S, et al. A traditional diet is associated with a reduced risk of eczema and wheeze in Colombian children. Nutrients. 2015;7(7):5098–5110    Castro-Rodriguez JA, RamirezHernandez M, Padilla O, PachecoGonzalez RM, Pérez-Fernández V, Garcia-Marcos L. Effect of foods and Mediterranean diet during pregnancy and first years of life on wheezing, rhinitis and dermatitis in preschoolers. Allergol Immunopathol (Madr). 2016;44(5):400–409 125. Pepino VC, Ribeiro JD, Ribeiro MA,    Jacka, Felice & Kremer, Peter & Berk, Michael & de Silva-Sanigorski, Andrea & Moodie, Marjory & Leslie, Eva & Pasco, Julie & Swinburn, Boyd. (2011). A Prospective Study of Diet Quality and Mental Health in Adolescents. PloS one. 6. e24805. 10.1371/journal.pone.0024805.    Loewen OK, Maximova K, Ekwaru JP, Faught EL, Asbridge M, Ohinmaa A, Veugelers PJ. Lifestyle Behavior and Mental Health in Early Adolescence. Pediatrics. 2019 May;143(5):e20183307. doi: 10.1542/peds.2018-3307. Epub 2019 Apr 19. PMID: 31004047.   Ventriglio A, Sancassiani F, Contu MP, et al. Mediterranean Diet and its Benefits on Health and Mental Health: A Literature Review. Clin Pract Epidemiol Ment Health. 2020;16(Suppl-1):156-164. Published 2020 Jul 30. doi:10.2174/1745017902016010156   Oddo, V. M., Welke, L., McLeod, A., Pezley, L., Xia, Y., Maki, P., Koenig, M. D., Kominiarek, M. A., Langenecker, S., & Tussing-Humphreys, L. (2022). Adherence to a Mediterranean Diet Is Associated with Lower Depressive Symptoms among U.S. Adults. Nutrients, 14(2), 278. https://doi.org/10.3390/nu14020278   Yin, W., Löf, M., Chen, R., Hultman, C. M., Fang, F., & Sandin, S. (2021). Mediterranean diet and depression: a population-based cohort study. The international journal of behavioral nutrition and physical activity, 18(1), 153. https://doi.org/10.1186/s12966-021-01227-3

Commentary by Dr. Valentin Fuster

Cristian Navarrete-Dechent, MD interviewed by Maral Skelsey, MD, FAAD

'Tis the season for Christmas cookies, peppermint everything, parties galore, and sometimes a weekend that doesn't go exactly as planned. Whether you are listening to this podcast during the holiday season or in the middle of the summer after a weekend of pool parties + BBQ, you are in just the right place to get yourself back on track this week!In today's episode, I share various tactics to get you back to feeling like yourself, no matter how "off" the last couple days have felt. I dive into the following 5 points:1. Stop beating yourself up2. Drink more water3. Don't go into crazy calorie restriction mode4. Move your body 5. Pause to reflect on what instigated the overindulgenceHere are some additional episodes to check out (those mentioned in this show):10 Ways to Stay on Track With Your Habits Through the Holidays4 Sneaky Stressors That Are Stealing Your Progress, Your Waistline + Your Life7 Ways to Increase Your Hydration For Weight Loss, Better Brain Function + MoreAnd here is the research that I referenced at the beginning of the show, all about holiday weight gain:A Prospective Study of Holiday Weight GainHoliday weight gain: Americans expect to add 8 pounds over the next monthThank YOU for making this show possible! If you are grateful for this free content I would love to hear from you in the podcast ratings + reviews!For more information on my coaching services and for tons of healthy recipes check out www.fitfeedbyreed.com

Dr. Sue Yom, Editor in Chief, hosts Dr. Scott Soltys, Professor of Radiation Oncology from Stanford University and outgoing Section CNS Section Editor, along with Dr. Daniel Trifiletti, Associate Professor at Mayo Clinic Florida and CNS Associate Section Editor who first-authored this month's OncoScan, entitled "Novel Applications of Stereotactic Radiosurgery Beyond Oncology: Prospective Trials in Functional Radiosurgery," and Dr. Valentina Pinzi, Senior Assistant in the Department of Neurosurgery Radiotherapy Unit of the Neurological Institute Carlo Besta in Milan, who is the lead author of an article in this month's issue, "Hypofractionated Radiosurgery for Large or in Critical-Site Intracranial Meningioma: Results of a Phase 2 Prospective Study."

2023 RWCS Meeting Dr. Arthur Kavanaugh invites you to join him for the 2023 RWCS meeting in February 2023. Dr David Liew JAK inhibitor VS TNF inhibitor, Infections in East Asian Patients. Abstract 302 Early Diagnosis of Axial Spondyloarthritis Dr. Antoni Chan talks with Dr.  Nelly Ziade at ACR22 Convergence in Philadelphia, PA. Abstracts 1512: What Is the Best Referral Strategy for Axial Spondyloarthritis? A Prospective Multicenter Study of 515 Patients with Suspicious Chronic Low Back Pain Abstract 1517: Value of the Anti-CD74 Antibodies for the Diagnosis of Axial Spondyloarthritis: Results of a Prospective Study in Patients with Suspicious Low Back Pain New Treatments for SLE? Dr. Michelle Petri discusses abstract 1117 presented at ACR22 Convergence meeting in Philadelphia, PA.  Abstract 1117: Efficacy and Safety of Deucravacitinib, an Oral, Selective, Allosteric TYK2 Inhibitor, in Patients with Active Systemic Lupus Erythematosus: A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study

Prospective Study on Observations of γ-Ray Sources in the Galaxy Using the HADAR Experiment by Xiangli Qian et al. on Sunday 25 September The High Altitude Detection of Astronomical Radiation (HADAR) experiment is a refracting terrestrial telescope array based on the atmospheric Cherenkov imaging technique. It focuses the Cherenkov light emitted by extensive air showers through a large aperture water-lens system for observing very-high-energy-rays and cosmic rays. With the advantages of a large field-of-view (FOV) and low energy threshold, the HADAR experiment operates in a large-scale sky scanning mode to observe galactic sources. This study presents the prospects of using the HADAR experiment for the sky survey of TeV {gamma}-ray sources from TeVCat and provids a one-year survey of statistical significance. Results from the simulation show that a total of 23 galactic point sources, including five supernova remnant sources and superbubbles, four pulsar wind nebula sources, and 14 unidentified sources, were detected in the HADAR FOV with a significance greater than 5 standard deviations ({sigma}). The statistical significance for the Crab Nebula during one year of operation reached 346.0 {sigma} and the one-year integral sensitivity of HADAR above 1TeV was ~1.3%-2.4% of the flux from the Crab Nebula. arXiv: http://arxiv.org/abs/http://arxiv.org/abs/2209.11458v1

This special edition podcast highlights the top 10 articles of 2021  that caught the most public attention based on their Altmetric scores. 1. Effectiveness of Adding a Large Dose of Shoulder Strengthening to Current Nonoperative Care for Subacromial Impingement: A Pragmatic, Double-Blind Randomized Controlled Trial (SExSI Trial) 2. Systematic Video Analysis of Anterior Cruciate Ligament Injuries in Professional Female Soccer Players 3. Can Biomechanical Testing After Anterior Cruciate Ligament Reconstruction Identify Athletes at Risk for Subsequent ACL Injury to the Contralateral Uninjured Limb? 4. High Risk of New Knee Injuries in Female Soccer Players After Primary Anterior Cruciate Ligament Reconstruction at 5- to 10-Year Follow-up 5. Biomechanical but Not Strength or Performance Measures Differentiate Male Athletes Who Experience ACL Reinjury on Return to Level 1 Sports 6. Effect of Autologous Expanded Bone Marrow Mesenchymal Stem Cells or Leukocyte-Poor Platelet-Rich Plasma in Chronic Patellar Tendinopathy (With Gap >3 mm): Preliminary Outcomes After 6 Months of a Double-Blind, Randomized, Prospective Study 7. Blood Flow Restriction Training for Athletes: A Systematic Review 8. Scapular Dyskinesis Is Not an Isolated Risk Factor for Shoulder Injury in Athletes: A Systematic Review and Meta-analysis 9. Anterior Shoulder Instability in Throwers and Overhead Athletes: Long-term Outcomes in a Geographic Cohort 10. No Additive Clinical or Physiological Effects of Short-term Anti-inflammatory Treatment to Physical Rehabilitation in the Early Phase of Human Achilles Tendinopathy: A Randomized Controlled Trial

Drs. Ken Noonan of U. Wisconsin and Aristides "JR" Cruz of Brown join the podcast for a special JPOSNA episode. They serve as Editor-in-chief and Deputy Editor of the journal, respectively, and they have exciting news to share about JPOSNA. We also discuss some of our favorite JPOSNA content from 2021. Your hosts are Carter Clement from Children's Hospital of New Orleans and Josh Holt from University of Iowa. Music by A. A. Alto.   JPOSNA Publications Discussed:   "Effectiveness of Various Cast Covers in the Pediatric Population." https://www.jposna.org/ojs/index.php/jposna/article/view/302   "Operative Versus Nonoperative Treatment of Z-Type Comminuted Clavicle Fractures in Adolescents: A Sub-stratified Cohort Analysis." https://www.jposna.org/ojs/index.php/jposna/article/view/301   "What are the Causes and Consequences of Delayed Surgery for Pediatric Tibial Spine Fractures?" https://www.jposna.org/ojs/index.php/jposna/article/view/297   Video: "Tibial Spine/Eminence Fracture – Suture Fixation." https://www.jposna.org/ojs/index.php/jposna/article/view/298   "Nonoperative Management of Femoroacetabular Impingement: Clinical Outcomes at 5-years – A Prospective Study." https://www.jposna.org/ojs/index.php/jposna/article/view/299   "Activation of a Central Immunosuppressive Cascade Prevents Ischemia Reperfusion Injury After Acute Compartment Syndrome in a Murine Model." https://www.jposna.org/ojs/index.php/jposna/article/view/300    

Proper portion sizing is one of the most confusing things out there, but you'll be a pro after listening to this episode. Inside, I explain: - the difference between portion size and serving size - how to use serving sizes and tracking as a tool instead of a way of life - how to increase your portion sizes if you've been restricting - why you don't need to go through life trying to eat as little as possible ... and more! Show Notes: Schedule a 1:1 Discovery Call Serving Sizes & Portions Orthorexia nervosa vs. healthy orthorexia: relationships with disordered eating, eating behavior, and healthy lifestyle choices It's complicated: The relationship between orthorexia and weight/shape concerns, eating behaviors, and mood Dieting Increases the Likelihood of Subsequent Obesity and BMI Gain: Results from a Prospective Study of an Australian National Sample Why do dieters regain weight? Reverse dieting: Can you really get better results by eating more? The F*ck It Diet You can learn more about me by following on IG @imperfectlypaigewellness or by checking out my blog, freebies, and offers on my website: https://imperfectlypaigewellness.com Please share with #PaigeTalksWellness to help get the word out about the show - and join the Imperfect Health Fam over on Facebook.

Special live session from the 2021 AAOS Meeting in San Diego. Featuring special guest Rachel Goldstein from CHLA who joins us to discuss DDH. Discussion focuses on ultrasound assessment of children with dysplasia and the ominous finding of an inverted labrum. We also dive into other recent studies in the lightning round discussing the femoral head-shaft angle in children with Cerebral Palsy, NOF of the distal tibia, the effects of lumbar fusion on cervical sagittal alignment in patients with Lenke 5 AIS, and the ease of acquiring skills to diagnose DDH via ultrasound enhanced physical examination. Your hosts are Josh Holt from The University of Iowa, Carter Clement from Children's Hospital of New Orleans, and Julia Sanders from Children's Hospital Colorado. Music by A.A. Alto.   Featured article: An Inverted Acetabular Labrum is Predictive of Pavlik Harness Treatment Failure in Children with Developmental Hip Dysplasia. Adrian Lin, Ali Siddiqui, Lillian Lai, Rachel Goldstein. JPO. Sept 2021.   Lightning Round: 1. The Femoral Head-Shaft Angle is Not a Predictor of Hip Displacement in Children Under 5 Years with Cerebral Palsy: A Population-based Study of Children at GMFCS Levels III-V. Terje Terjesen, Joachim Horn. JPO. 2021   2. Nonossifying Fibroma of the Distal Tibia: Predictors of Fracture and Management Algorithm. Soroush Baghdadi, Jie Nguyen, Alexandre Arkader. JPO. 2021   3. Does Selective Posterior Correction and Fusion Surgery Influence Cervical Sagittal Alignment in Patient with Lenke Type 5 Adolescent Idiopathic Scoliosis?- A 5-year Follow-up Retrospective Cohort Study. Toshiki Okubo, Mitsuru Yagi, Satoshi Suzuki et al. Spine. 2021   4. What is the Intraobserver Reliability of an Ultrasound-enhanced Physical Examination of the Hip in Infants? A Prospective Study on the Ease of Acquiring Skills to Diagnose Hip Dysplasia. Neha Jejurikar, Leon Moscona-Mishy, Monica Rubio, Romina Cavallaro, Pablo Castaneda. COOR. 2021

Contributor: Nick Tsipis, MD Educational Pearls: Prospective trial studied 5 mg IM droperidol to 10 mg IM olanzapine (Zyprexa) in the reducing levels of agitation Time to adequate sedation was about 16 minutes for both agents Droperidol was slightly less sedating than olanzapine and length of stay for olanzapine was longer Olanzapine had a higher rate of requiring another agent for adequate sedation Droperidol had a higher rate of adverse events (mainly extrapyramidal symptoms) than olanzapine Remember to put the safety of the staff and patient at the forefront of sedation practices and be cognizant of the psychological effect of giving involuntary medications to patients References Cole JB, Stang JL, DeVries PA, Martel ML, Miner JR, Driver BE. A Prospective Study of Intramuscular Droperidol or Olanzapine for Acute Agitation in the Emergency Department: A Natural Experiment Owing to Drug Shortages. Ann Emerg Med. 2021;78(2):274-286. doi:10.1016/j.annemergmed.2021.01.005 Summarized by John Spartz, MS4 | Edited by Erik Verzemnieks, MD   The Emergency Medical Minute is excited to announce that we are now offering AMA PRA Category 1 credits™ via online course modules. To access these and for more information, visit our website at https://emergencymedicalminute.org/cme-courses/ and create an account.  Donate to EMM today!

In this month's episode, Dr. Krishna Rajajee, Clinical Professor in Neurosurgery and Neurology at the University of Michigan. is interviewed by Drs. Kassi Kronfeld and Jason Siegel on his recent article, "A Prospective Study of Optic Nerve Ultrasound for the Detection of Elevated Intracranial Pressure in Severe Traumatic Brain Injury." NCS offers free CE credits for the NCS Podcast Series episodes. Listen to any of the posted episodes, complete a five question survey, and claim your credits here! Credits are available for physicians, pharmacists, nurses, and non-physicians. The NCS Podcast is the official podcast of the Neurocritical Care Society. Our senior producer is Bonnie Rossow. Our host is Fawaz Almufti, and our production staff includes Tareq Saad Almaghrabi, Andrew Bauerschmidt, Leonid Groysman, Atul Kalanuria, Lauren Koffman, Kassi Kronfeld, Holly Ledyard, Lindsay Marchetti, Alexandra Reynolds, Lucia Rivera Lara, Jon Rosenberg, Jason Siegel, Zachary Threlkeld, Teddy Youn, and Chris Zammit. Our administrative staff includes Bonnie Rossow. Music by Mohan Kottapally.

Another rant-filled episode of the Nate and Hannah series. Nate and I talk about a couple of awesome “success” stories in the clinic, some crazy stories our patients have told us, and we discuss the recent hot topics of neutral spines, text neck, and forward head posture. - The power of simple strength training - The power of misinformation - Self-efficacy - Stress and adaptation - Cortisone, Hyaluronic acid, dry needling, and pain - Knees over toes - Loss of cervical curvature and lack of evidence www.made2movept.com @made2movept @hannahbreal_dpt @nathanjones9000 References: Brinjikji, Waleed, et al. "Systematic literature review of imaging features of spinal degeneration in asymptomatic populations." American Journal of Neuroradiology 36.4 (2015): 811-816. Horga, Laura M., et al. "Prevalence of abnormal findings in 230 knees of asymptomatic adults using 3.0 T MRI." Skeletal radiology 49.7 (2020): 1099-1107. Hartmann, Hagen, Klaus Wirth, and Markus Klusemann. "Analysis of the load on the knee joint and vertebral column with changes in squatting depth and weight load." Sports medicine 43.10 (2013): 993-1008. Lippa, Laura, Luciano Lippa, and Francesco Cacciola. "Loss of cervical lordosis: What is the prognosis?." Journal of craniovertebral junction & spine 8.1 (2017): 9. Richards, Karen V., et al. "Is Neck Posture Subgroup in Late Adolescence a Risk Factor for Persistent Neck Pain in Young Adults? A Prospective Study." Physical Therapy (2021).

Another rant-filled episode of the Nate and Hannah series. Nate and I talk about a couple of awesome “success” stories in the clinic, some crazy stories our patients have told us, and we discuss the recent hot topics of neutral spines, text neck, and forward head posture. - The power of simple strength training - The power of misinformation - Self-efficacy - Stress and adaptation - Cortisone, Hyaluronic acid, dry needling, and pain - Knees over toes - Loss of cervical curvature and lack of evidence www.made2movept.com @made2movept @hannahbreal_dpt @nathanjones9000 References: Brinjikji, Waleed, et al. "Systematic literature review of imaging features of spinal degeneration in asymptomatic populations." American Journal of Neuroradiology 36.4 (2015): 811-816. Horga, Laura M., et al. "Prevalence of abnormal findings in 230 knees of asymptomatic adults using 3.0 T MRI." Skeletal radiology 49.7 (2020): 1099-1107. Hartmann, Hagen, Klaus Wirth, and Markus Klusemann. "Analysis of the load on the knee joint and vertebral column with changes in squatting depth and weight load." Sports medicine 43.10 (2013): 993-1008. Lippa, Laura, Luciano Lippa, and Francesco Cacciola. "Loss of cervical lordosis: What is the prognosis?." Journal of craniovertebral junction & spine 8.1 (2017): 9. Richards, Karen V., et al. "Is Neck Posture Subgroup in Late Adolescence a Risk Factor for Persistent Neck Pain in Young Adults? A Prospective Study." Physical Therapy (2021).

脖子痛都是姿勢不良的錯？ 你才姿勢不良，你全家都姿勢不良XD 彎腰駝背才不會脖子痛，不要再道聽塗說了。 那什麼樣的人才容易有脖子痛呢？原來女性本身就比男性還要容易脖子痛啊！ Timecode: 00:30 新年新希望，騙流量(?)，clubhouse想法 05:00 Neck pain的流行病學 10:10 Neck pain 危險因子，單車選手脖子痛 16:30 Neck pain與posture的關聯性: 工作環境配置，彎腰駝背真的會造成脖子痛(?) 24:00 長期詭異姿勢可能會有costospinal pain 25:30 病因？v.s. 要做什麼病患會比較好？ 27:30 Neck pain clinical course 頸痛的病程演變 28:50 Whiplash 鞭甩症候群與注意事項 31:50 2017 病程演變更新 34:00 Acute cervical radiculopathy 急性頸椎神經根病症 41:00 預後 (prognosis) 42:45 危險因子與預後因子的差異 45:50 對neck pain預後沒有影響的因子：頸部活動度、姿勢等等 48:30 neck pain病程段落小結 49:30 心理相關與病患溝通 51:45 如何辨別病患是否有心理壓力傾向 57:20 總結 歡迎到各平台追蹤或來信來訊跟我們提出疑問～ Facebook: https://www.facebook.com/2PROPT/ Instagram: https://www.instagram.com/2pro_pt/ Email: 2propt@gmail.com 也可以在此收聽： Apple podcast: https://tinyurl.com/y97q7tms Spotify: https://tinyurl.com/ydavzqxu Google podcast: https://tinyurl.com/yd86pbcl YouTube channel: https://tinyurl.com/y82ewo5b Reference: Blanpied PR, Gross AR, Elliott JM, et al. Robertson. Neck Pain: Revision 2017. JOSPT 2017 47:7, A1-A83 Richards KV, Beales DJ, Smith AL, O'Sullivan PB, and Straker LM. Is Neck Posture Subgroup in Late Adolescence a Risk Factor for Persistent Neck Pain in Young Adults? A Prospective Study, Physical Therapy. 2021. Music by Elizabeth's Groove by Amarià @amariamusique Creative Commons — Attribution 3.0 Unported — CC BY 3.0 Free Download / Stream: bit.ly/elizabeths-groove Music promoted by Audio Library youtu.be/-MO-mrBlo5s

Dr. Jennifer Frontera discusses her paper, "A Prospective Study of Neurologic Disorders in Hospitalized COVID-19 Patients in New York City". Show references: https://n.neurology.org/content/early/2020/10/05/WNL.0000000000010979

Dr. Dononvan summarizes the recent article "A Prospective Study of Concussions and Health Outcomes in High School Football Players" by Timothy A. McGuine, PhD, ATC; Adam Pfaller, MD; Scott Hetzel, MS; Steven P. Broglio, PhD, ATC, FNATA; Erin Hammer, MD, MPH.

On Episode #10, here are the main topics:1. The 2020 Nobel prize in Chemistry was awarded for the discovery of a genetic engineering technique. With all its benefits, the technique has some seriously concerned about its ethical implications.2. Studies suggest that coronavirus could lead to neurological illnesses3. New research reveals why coronavirus that once lived harmlessly in bats and other wildlife – has become uncontrollable once it jumped the species barrier and entered humans.ReferencesDoudna, J. A., & Charpentier, E. (2014). The new frontier of genome engineering with CRISPR-Cas9. Science, 346(6213).Frontera, J. A., Sabadia, S., Lalchan, R., Fang, T., Flusty, B., Millar-Vernetti, P., ... & Morgan, N. (2020). A Prospective Study of Neurologic Disorders in Hospitalized COVID-19 Patients in New York City. Neurology.Alejandro Berrio, Valerie Gartner, Gregory A. Wray. Positive selection within the genomes of SARS-CoV-2 and other Coronaviruses independent of impact on protein function. PeerJ, 2020; 8: e10234

Donelson R, April C, Medcalf R, Grant W. A Prospective Study of Centralization of Lumbar and Referred Pain: A predictor of Symptomatic Discs and Anular Competence. Spine. 1997;22(10):1115-1122. --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app

Wesley Talcott, MD, and Sue Evans, MD, MPH join PRO Senior Editor Bhisham Chera, MD, to discuss their article “A Blinded, Prospective Study of Error Detection During Physician Chart Rounds in Radiation Oncology .” The authors discuss their motivation for the study, how plan review and chart rounds can be more effective, and more. Also available in the September-October 2020 issue of PRO is an accompanying editorial by Dr. Chera, “Restructuring our approach to peer review: a critical need to improve the quality and safety of radiation therapy .” For those interested in expanding their peer review pool, see the new ASTRO Peer-to-Peer Match program, a user-driven platform that facilitates the establishment of relationships for the purpose of peer review of patient cases.

Injuries to the hamstring complex most commonly involve the proximal musculotendinous junction of the long head of the biceps femoris (MTJ-BFlh). Nonoperative management of these injuries is associated with prolonged rehabilitation and high risk of recurrence. To our knowledge, the surgical management of acute MTJ-BFlh injuries has not been previously reported. In conclusion, surgical repair of acute MTJ-BFlh injuries enables return to preinjury level of sporting function with low risk of recurrence at short-term follow-up.   Click here to read the article.

Today on the show, I am joined by Laura K. Barger. Dr. Barger, an Assistant Professor at the Harvard Medical School as well as an associate Physiologist at the Brigham and Women's Hospital in Boston, Massachusets. Dr. Barger is researching things like the effects of spaceflight on sleep and the circadian timing system, effects of extended work hours, and the subsequent sleep loss on health and safety through a NASA-funded spaceflight project.As part of her work, she has assessed the impact of extended work hours on the health and safety of workers and the public. She has implemented and evaluated fatigue management and sleep disorders screening programs in groups that work non-standard hours, such as, guess who: police officers, firefighters, and other weirdos like us. I had a great time talking to Dr. Barger, and I think we, as firefighters, can all agree, we need to put a bigger emphasis on being well-rested so we can perform on the job and at home for our families.Links:Laura K. Barger, Ph.D. Harvard Faculty ProfileStudy: Common Sleep Disorders Increase Risk of Motor Vehicle Crashes and Adverse Health Outcomes in FirefightersStudy: Randomized, Prospective Study of the Impact of a Sleep Health Program on Firefighter Injury and DisabilityFatigue Cost Calculator

Martin KD, McBride T, Unangst A, Chisholm J. Prospective Study of Military Special Operations Medical Personnel and Lower Extremity Fracture Immobilization in an Austere Environment. Foot Ankle Ortho; 2020,5(2):1-6. https://doi.org/10.1177/2473011420916144

In this video, Michael Prats, MD (guest host!) and Jacob Avila sit down with Yale Tung Chen and speak with him regarding his article, Results of a Prospective Study to Evaluate the Impact of Point-of-Care Ultrasound in the Enhancement of Gastrointestinal Bleeding Risk Scores. In this study, Dr. Chen showed that ultrasound was able to prognosticate hemodynamically stable patients for bad outcomes down the road.  Here's the link to the study. Interested in an online ultrasound fellowship? Check out www.ultrasoundleadershipacademy.com

Dr. Karin Arsenault Dr. Karin Andrenyi-Arsenault graduated with a Bachelor of Science in Anatomy from McGill University. She earned her Doctor of Dental Medicine from Tufts University School of Dental Medicine in 1994 and went on to receive a Master’s in Public Health in Health Care Management from Harvard University. She completed a Mini-Residency in Geriatric and Long-Term Care at the University of Minnesota. She held the position of Dental Director at the South Boston Community Health Center and later was involved in developing and implementing the group practice clinical system at Tufts University School of Dental Medicine. In January, she returned to academia to pursue her interests in geriatrics and public health as Clinical Director of the Geriatric Center Program.   References: D. S. Michaud, et. al. “A Prospective Study of Periodontal disease and Pancreatic Cancer in US Male Health Professionals",, JNCI, 2007. Catherine Saint Louis, In Nursing Homes, an Epidemic of Poor Dental Hygiene" NYT, 2013. Helene Ragovin, For Most Seniors, Oral Health Goes Uncovered" Tufts Now, 2019. "Experts discuss oral health disparities, issues affecting older Americans", ADANEWS, 2016.

Eating foods prepared away from home is a popular behavior in the U S population. In 2005–2008, over a third of the daily energy intake in the U S came from foods prepared away from home. Restaurant prepared foods are known to be energy-dense, and higher in fat and sodium, but lower in protective nutrients. To our knowledge there are no published prospective studies of the association of restaurant meal exposure with the risk of cardiometabolic and all-cause mortality in the U S population. To fill these gaps, we examined the prospective association of frequency of eating restaurant prepared meals and risk of all-cause and cardiometabolic mortality in a representative sample of the U S population. Given some prior reports of adverse cardiometabolic risk biomarker profiles of frequent consumers of restaurant meals, we also examined cross-sectional associations of cardiometabolic biomarkers with frequency of eating away from home meals. Kant AK et al. (2018) A prospective study of frequency of eating restaurant prepared meals and subsequent 9-year risk of all-cause and cardiometabolic mortality in U S adults. PLoS One. 13(1): e0191584. doi: 10.1371/journal.pone.0191584. This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication. Sections of the Introduction and Discussion are presented in the Podcast. Access the full-text article here: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5779659/

Epidural Steroid Injection vs. the MILD Procedure in Lumbar Spinal Stenosis. Meet Dr. Rosenblum at NANS this January in Las Vegas. Subscribe to our mailing list * indicates required Email Address *   Download the PainExam App for iPhone and Android DISCLAIMER: Doctor Rosenblum IS HERE SOLELY TO EDUCATE, AND YOU ARE SOLELY RESPONSIBLE FOR ALL YOUR DECISIONS AND ACTIONS IN RESPONSE TO ANY INFORMATION CONTAINED HEREIN. This podcasts is not intended as a substitute for the medical advice of physician to a particular patient or specific ailment.  You should regularly consult a physician in matters relating to yours or another's health.  You understand that this podcast is not intended as a substitute for consultation with a licensed medical professional References A Double‐blind, Randomized, Prospective Study of Epidural Steroid Injection vs. The mild®Procedure in Patients with Symptomatic Lumbar Spinal Stenosis Lora L. Brown MD Coastal Orthopedics and Sports Medicine, Bradenton, Florida, U.S.A. Search for more papers by this author Lora L. Brown MD Coastal Orthopedics and Sports Medicine, Bradenton, Florida, U.S.A. Search for more papers by this author First published: 25 January 2012 https://doi.org/10.1111/j.1533-2500.2011.00518.x Cited by: 29 Address correspondence and reprint requests to: Lora L. Brown, MD, Coastal Orthopedics and Sports Medicine, 6015 Pointe West Blvd., Bradenton, FL 34209, U.S.A. E‐mail: painmedicinedoctor@hotmail.com.

Discussion of a recent study that evaluated prospectively psychosocial well being measures in breast cancer patients before and after receipt of CPM. Read the related article "Prospective Study of Psychosocial Outcomes of Having Contralateral Prophylactic Mastectomy Among Women With Nonhereditary Breast Cancer" on JCO.org

The journal Neurology published a paper called “Prospective Study of Restless Legs Syndrome and Total and Cardiovascular Mortality Among Women.” This study proves to me that your leg cramps are telling you that your magnesium deficiency is serious and needs to be remedied.  Why? Because I’ve seen countless people eliminate their symptoms of leg cramps / Restless Leg Syndrome when they take ReMag and when people have magnesium deficiency they are at risk for CV disease. The highest amounts of magnesium in the body are in the heart so if there is magnesium deficiency, the heart is at risk. The association between restless legs and CV disease places the blame on magnesium deficiency as the shared cause. RLS is said to be a sleep and a neurological sensory disorder, which tells me nothing about its cause. In fact, medicine has no idea what causes RLS or how to treat it. This latest study just makes people with RLS more anxious because they have been told there is no cure for RLS and now they are told it increases their risk of heart disease. RLS symptoms occur at rest, lying, or sitting and include creeping, crawling, tingling, pulling, twitching, tearing, aching, throbbing, prickling, or grabbing sensations in the calves. The result is an uncontrollable urge to relieve the uncomfortable sensation by moving the legs. Some research shows that people with RLS may suffer from iron deficiency. However, Professor Nordlander who came up with this theory admits that only about 15% of the RLS clinical population appears to have peripheral iron deficiency (serum ferritin < 50 mcg/l). Yet, 20-50mcg/l is said to be the optimal level for ferritin and indicates you don’t have iron overload and taking iron could increase iron toxicity in the body. Professor Nordlander won’t drop his theory and says there can exist an iron deficiency in the tissues in spite of normal serum iron. At his insistence, researchers are investigating low iron levels in the brain! Unfortunately, you can cause more problems by taking unnecessary iron. People do have to be careful of self-medicating with iron. Investigators are also looking at dopamine because drugs that stimulate dopamine production may help the symptoms of RLS. And, of course, they are investigating the role genes play in RLS. Nowhere in mainstream literature do I see magnesium being studied in the diagnosis and treatment of RLS. Yet, every day we hear stories of people who take ReMag and say their RLS symptoms disappear – which means they were suffering from magnesium deficiency. It just makes sense to investigate magnesium deficiency as a cause of RLS before taking iron or dopamine drugs or just giving up and blaming your genes.

The journal Neurology published a paper called “Prospective Study of Restless Legs Syndrome and Total and Cardiovascular Mortality Among Women.” This study proves to me that your leg cramps are telling you that your magnesium deficiency is serious and needs to be remedied.  Why? Because I’ve seen countless people eliminate their symptoms of leg cramps / Restless Leg Syndrome when they take ReMag and when people have magnesium deficiency they are at risk for CV disease. The highest amounts of magnesium in the body are in the heart so if there is magnesium deficiency, the heart is at risk. The association between restless legs and CV disease places the blame on magnesium deficiency as the shared cause. RLS is said to be a sleep and a neurological sensory disorder, which tells me nothing about its cause. In fact, medicine has no idea what causes RLS or how to treat it. This latest study just makes people with RLS more anxious because they have been told there is no cure for RLS and now they are told it increases their risk of heart disease. RLS symptoms occur at rest, lying, or sitting and include creeping, crawling, tingling, pulling, twitching, tearing, aching, throbbing, prickling, or grabbing sensations in the calves. The result is an uncontrollable urge to relieve the uncomfortable sensation by moving the legs. Some research shows that people with RLS may suffer from iron deficiency. However, Professor Nordlander who came up with this theory admits that only about 15% of the RLS clinical population appears to have peripheral iron deficiency (serum ferritin < 50 mcg/l). Yet, 20-50mcg/l is said to be the optimal level for ferritin and indicates you don’t have iron overload and taking iron could increase iron toxicity in the body. Professor Nordlander won’t drop his theory and says there can exist an iron deficiency in the tissues in spite of normal serum iron. At his insistence, researchers are investigating low iron levels in the brain! Unfortunately, you can cause more problems by taking unnecessary iron. People do have to be careful of self-medicating with iron. Investigators are also looking at dopamine because drugs that stimulate dopamine production may help the symptoms of RLS. And, of course, they are investigating the role genes play in RLS. Nowhere in mainstream literature do I see magnesium being studied in the diagnosis and treatment of RLS. Yet, every day we hear stories of people who take ReMag and say their RLS symptoms disappear – which means they were suffering from magnesium deficiency. It just makes sense to investigate magnesium deficiency as a cause of RLS before taking iron or dopamine drugs or just giving up and blaming your genes.

The journal Neurology published a paper called “Prospective Study of Restless Legs Syndrome and Total and Cardiovascular Mortality Among Women.” This study proves to me that your leg cramps are telling you that your magnesium deficiency is serious and needs to be remedied.  Why? Because I’ve seen countless people eliminate their symptoms of leg cramps / Restless Leg Syndrome when they take ReMag and when people have magnesium deficiency they are at risk for CV disease. The highest amounts of magnesium in the body are in the heart so if there is magnesium deficiency, the heart is at risk. The association between restless legs and CV disease places the blame on magnesium deficiency as the shared cause. RLS is said to be a sleep and a neurological sensory disorder, which tells me nothing about its cause. In fact, medicine has no idea what causes RLS or how to treat it. This latest study just makes people with RLS more anxious because they have been told there is no cure for RLS and now they are told it increases their risk of heart disease. RLS symptoms occur at rest, lying, or sitting and include creeping, crawling, tingling, pulling, twitching, tearing, aching, throbbing, prickling, or grabbing sensations in the calves. The result is an uncontrollable urge to relieve the uncomfortable sensation by moving the legs. Some research shows that people with RLS may suffer from iron deficiency. However, Professor Nordlander who came up with this theory admits that only about 15% of the RLS clinical population appears to have peripheral iron deficiency (serum ferritin < 50 mcg/l). Yet, 20-50mcg/l is said to be the optimal level for ferritin and indicates you don’t have iron overload and taking iron could increase iron toxicity in the body. Professor Nordlander won’t drop his theory and says there can exist an iron deficiency in the tissues in spite of normal serum iron. At his insistence, researchers are investigating low iron levels in the brain! Unfortunately, you can cause more problems by taking unnecessary iron. People do have to be careful of self-medicating with iron. Investigators are also looking at dopamine because drugs that stimulate dopamine production may help the symptoms of RLS. And, of course, they are investigating the role genes play in RLS. Nowhere in mainstream literature do I see magnesium being studied in the diagnosis and treatment of RLS. Yet, every day we hear stories of people who take ReMag and say their RLS symptoms disappear – which means they were suffering from magnesium deficiency. It just makes sense to investigate magnesium deficiency as a cause of RLS before taking iron or dopamine drugs or just giving up and blaming your genes.

The journal Neurology published a paper called “Prospective Study of Restless Legs Syndrome and Total and Cardiovascular Mortality Among Women.” This study proves to me that your leg cramps are telling you that your magnesium deficiency is serious and needs to be remedied.  Why? Because I’ve seen countless people eliminate their symptoms of leg cramps / Restless Leg Syndrome when they take ReMag and when people have magnesium deficiency they are at risk for CV disease. The highest amounts of magnesium in the body are in the heart so if there is magnesium deficiency, the heart is at risk. The association between restless legs and CV disease places the blame on magnesium deficiency as the shared cause. RLS is said to be a sleep and a neurological sensory disorder, which tells me nothing about its cause. In fact, medicine has no idea what causes RLS or how to treat it. This latest study just makes people with RLS more anxious because they have been told there is no cure for RLS and now they are told it increases their risk of heart disease. RLS symptoms occur at rest, lying, or sitting and include creeping, crawling, tingling, pulling, twitching, tearing, aching, throbbing, prickling, or grabbing sensations in the calves. The result is an uncontrollable urge to relieve the uncomfortable sensation by moving the legs. Some research shows that people with RLS may suffer from iron deficiency. However, Professor Nordlander who came up with this theory admits that only about 15% of the RLS clinical population appears to have peripheral iron deficiency (serum ferritin < 50 mcg/l). Yet, 20-50mcg/l is said to be the optimal level for ferritin and indicates you don’t have iron overload and taking iron could increase iron toxicity in the body. Professor Nordlander won’t drop his theory and says there can exist an iron deficiency in the tissues in spite of normal serum iron. At his insistence, researchers are investigating low iron levels in the brain! Unfortunately, you can cause more problems by taking unnecessary iron. People do have to be careful of self-medicating with iron. Investigators are also looking at dopamine because drugs that stimulate dopamine production may help the symptoms of RLS. And, of course, they are investigating the role genes play in RLS. Nowhere in mainstream literature do I see magnesium being studied in the diagnosis and treatment of RLS. Yet, every day we hear stories of people who take ReMag and say their RLS symptoms disappear – which means they were suffering from magnesium deficiency. It just makes sense to investigate magnesium deficiency as a cause of RLS before taking iron or dopamine drugs or just giving up and blaming your genes.

What is Heart Rate Variability (HRV)? -Chantea Goetz Heart rate variability is the change in the time intervals between consecutive heartbeats. Variations can be due to age, gender, athletic ability, circadian rhythms, core body temperature, and metabolism. 24-hour recordings are the gold standard. To measure the autonomic, cardiovascular, & respiratory systems a short-term reading of 5 minutes a day is sufficient. HRV is a critical indicator of health, resilience, well-being, and performance. Several research studies indicate that lowered HRV values lead to increased reports of diabetes, coronary disease, anxiety, depression, asthma, and poor performance. These aliments are due to autonomic dysregulation. HRV biofeedback positively effects the cardiovascular system, respiratory system, gastrointestinal system, performance, and behavior. The benefits of using HRV biofeedback has the ability for people to become aware of their proper breathing rate, also known as resonant frequency. Proper breathing patterns can improve professional and athletic performance, improve focus and concentration, reduce anxiety and depression symptoms, improve overall health and mental well-being, while reducing risk factors for disease. HRV biofeedback training involves slowing the breathing rate to achieve the RF breathe. For most people the respiratory sinus arrhythmia (RSA) is maximized when breathing at a rate of 6 breaths per minute. In order to obtain an ideal HRV there needs to be a balance between the parasympathetic and sympathetic nervous systems. When a person is over-stressed and under-recovered there will be a decline in performance. Some ways in which to separate emotional responses from physical actions are to practice mindfulness and meditation. My Journey in BioHacking Functional Fitness -Jim Goetz ​I work with people daily in order to help them achieve their goals and improve their way of life. What good is life if it's a life that's not worth living? Everyone deserves a happy and healthy life but many lack any clue on how to achieve this.  Goals are an essential part of health and happiness. Without setting objective goals, having a plan and being accountable to this plan, success will not happen.  What biohacking is and some thoughts on this were discussed in a recent interview I gave with The Vitamin Shoppe in their publication, What is Good.  My journey is not unlike any other. However the plan I use to achieve my goals is highly researched. As goals may be and should be in different aspects of life, this article focuses on health and fitness goals.  I began working out in the fourth grade. My grammar school teacher was not the best and as a result I became very unhappy. I found enjoyment through running, push ups, and sit ups. There was a burning sensation in either my legs, chest and arms or abs that was perplexing. The more I did, the more it burned. As an eight year old, this confusing sensation led to greater experimentation, which essentially meant to do more exercises. I would do these exercises daily, timing myself to see how long I could do them until the burn began and then how long I could push through the burn until I literally could not move that body part any longer. I was utilizing the most unscientific manner to increase lactic threshold and muscular endurance and function but for an eight year old, it made sense. My life was always filled with sports. Grammar school through high school it was cross country, basketball and baseball. In college it was baseball. Like most, I only did what the coach had me do. Like most I did not realize the coach had no clue himself in how to make better athletes.  It was in undergrad when I changed majors to exercise science that I began to learn new techniques in how to improve athletic ability. Some ideas worked for me, some did not. For instance, increasing carbohydrate intake before and after working out caused a dissipation of the visual appearance of muscle. In other words, carbs for energy and replenishment caused me to gain body fat. I also noticed that by consuming high carb meals the nigh before an event, I would wake up in the morning lethargic and with stomach pangs. I would also find that during a distance event, I would eventually feel depleted of all energy and not flow through the event as planned. Training for my first Tough Mudder was also an experiment. Though I ran long distances all my life, I loathed running at this point in my life. Instead of running, I did a spin class each morning and then later on would complete two circuits of six exercises with extremely heavy weight, being able to complete no more than 1-3 reps. I would move through this as fast yet efficient as possible. In the three months leading up to the Tough Mudder, I inadvertently lost 16 lbs and gained an incredible amount of strength. For example, before I began training I could do six pull ups. By the time three months passed, I was doing twenty pull ups at a time with ease. Through these two experiences and examples, I had self discovered methods that indeed were topics of research yet had no idea about it at the time. My journey to biohacking was well on the way before I had even heard of the idea of biohacking. ​ I went through an arduous two year period without access to a gym. I became weak to the point of no longer being able to do a pull up or a full range of motion dip. I lost forty pounds and was emaciated.  Refusing to be beat, I adapted and learned  I needed to make some changes and utilize every ounce of exercise science, physiology and neurology that I knew. I found rocks, concrete, steel pipes and built some awkward equipment that I could use and train in a functional manner. Each day I would apply the lessons I knew from the text books and research journals to my personal physical development. Some say nutrition is 80% of the solution when it comes to lean muscle gain and body fat loss. I personally believe it is closer to 90% of the solution. During the two year period without access to a gym, my access to nutritious food of any sort, even food in any quantity was limited at best. I was able to find access to large amounts of peanut butter, to which I hoarded and lived off of. In January of 2017, I weighed 160 lbs. I began to hone eating a ketogenic diet that I plan on keeping a lifestyle for the rest of my life. The science appears to be there for my Genotype that my physiology thrives on this manner of eating. I combined daily undulating periodization with cross fit workout of the days, power lifting for the lower extremity, Pilates, Olympic lifting and moderate distance running. On certain days, I utilize KAATSU and ensure I train all muscles every day in some manner yet ensure I do not go past no return so that I may properly recover. There is no one size fits all formula for success. Each individual has goals. Each individuals goals are unique and important to that person. Yet 95% of people will fail in their workout routine. This is due to a lack of setting a proper goal, lack of a plan towards that goal, and most importantly accountability to execute this plan on a daily basis. The book BioHacking Your Brain for Success: Becoming a True Champion in All Aspects of Life  written by myself and Chantea Goetz discusses this in great detail. There's a reason some people are successful in all they do. Others make excuses for their failure, which really is a result of never actually putting in any effort.  The most important aspect of success is passion!!! People tell me all the time they want to lose weight. I often tell them that there's no chance they will lose the weight and keep it off. They should save their money and do something enjoyable with it. Yes, these individuals are shocked at what I say but it is true. When one gets out of bed in the morning, they need to have a true passion and meaning in why they put their feet on the ground. If there's no passion for getting up, then the odds of success at an idea are futile at best. Does anyone really have a true passion for losing 20 lbs? They have the best intentions in the world but will assuredly fail.  Take that same person who is 20 lbs overweight and sign them up for a competition and they may find that passion in training. The 20 lb weight loss will occur as a result. As Yogi Berra once said, "half of the game is ninety percent mental". I can write the greatest program in the universe for someone to succeed. If there's no passion behind it then success is not happening. One has to show up to the field to play the game. Exercise is a lot more than simply opening up a magazine and doing chest and tri's on Monday, back and bi's on Tuesday, shoulders on Wednesday, skipping legs on Thursday because let's face it, doing legs suck and with all good intention of doing something Friday, it just does not happen. Most do "abs" every day, without ever being able to see a true six pack. So many aspects of this model are flawed from the get go. First and foremost, muscles only stay anabolic for around 48 hours. This means that after a tough "chest" day, by Wednesday this muscle ceases growth. Unfortunately, the overzealous weight lifter has damaged their muscle fibers too great to be able to work it again and is left with a muscle that is catabolic. Bodybuilders can get away with this because they are taking anabolic steroids. This keeps them anabolic all day and every day. For those of us not on performance enhancing drugs, we need to stay a few steps ahead of the game and can use science (BioHack) our way to our goals. Einstein defined insanity as doing the same thing over and over again and expecting different results. So why do the majority of individuals do this single or double body part split day week after week, month after month, and think they are making progress? If someone goes to the gym with no plan, how can they see if they are progressing and progressing in the right manner? That would be like a strength and conditioning coach having a professional football team "just go lift" as opposed to having a highly specialized and detailed season long program. Perhaps progress can be optimized if they followed the rules of human physiology. Yet people do this day after day, week after week, month after month until they realize they "will never" reach their goals and eventually give up. Daily undulated periodization (DUP) has a key, which is getting in maximum workout volume, without impacting recovery, which is why the undulating and periodization aspects are critical. One trains the entire body multiple times per week and utilizes different repetition ranges, thus focusing in on more specific muscle fiber types. Training in this manner has been shown to be more effective than linear exercise programming in terms of muscular hypertrophy, strength and endurance.  Combine DUP with KAATSU (vascular occlusion moderation training) and you get extreme muscle strength and growth in a far shorter time frame than would be believed. It is believed that the restricted blood flow recruits a greater number of fast twitch muscle fibers and even converts fibers to fast twitch. This combined with the increase in chemical mediators to repair tissues has been shown to have phenomenal results. High Intensity Interval Training (HIIT) has it's place for fat burning and strength training. Some utilize it to save time in a day. Others can utilize it to have amazing physical performance results.  ​Pilates is utilized for dexterity, flexibility, and fine tuning a strong core. This can be done literally by anyone. Never let a fat person on statins tell you how to eat. Never let a skinny person tell you how to lift. And never get accurate information from the media. Open up recent text books. Read peer reviewed journals and do critical appraisals on each article you consider utilizing. In the end, set your goals to mirror your passions. Set a realistic plan to achieve them and stay accountable each day towards it. Do this and welcome into your life the success you very much deserve. My goal...pull a 500 lb deadlift and on the same day run and complete an Iron Man triathalon. What's yours? Let's get to BioHacking our way there!!!! References: Jennifer T. Fine, Graham A. Colditz, Eugenie H. Coakley, George Moseley, JoAnn E. Manson, Walter C. Willett, and Ichiro Kawachi. A Prospective Study of Weight Change and Health-Related Quality of Life in Women . JAMA 1999 282: 2136-2142. Alfred Wirth and Jutta Krause. Long-term Weight Loss With Sibutramine: A Randomized Controlled Trial. JAMA 2001 286: 1331-1339 Shinichi Amano, Arimi Fitri Mat Ludin, Rachel Clift, et al. Effectiveness of blood flow restricted exercise compared with standard exercise in patients with recurrent low back pain: study protocol for a randomized controlled trial. Trials201617:81 Zourdos, Michael C.; Jo, Edward; Khamoui, Andy V. et al. Modified Daily Undulating Periodization Model Produces Greater Performance Than a Traditional Configuration in Powerlifters. Journal of Strength & Conditioning Research: March 2016 - Volume 30 - Issue 3 - p 784–791 Nicholas J Krilanovich. Benefits of ketogenic diets. Am J Clin Nutr January 2007  vol. 85 no. 1 238-239 BioHacking the Myths of Water -Dr. Michael Brandon, DC We all know that as long as we drink 8 cups of water a day our skin will be softer and glisten, we'll have a faster metabolism, better kidney function, we'll clear out toxins from our body, perform better, and lose weight.​ Well, now it's time to state that you have been lied to. In fact, only about half of that appears to hold any truth. The other half has either never been proven, or worse, been proven incorrect but is yet repeated to everybody as health advice. So what is false tales vs true benefits? Lets do what biohackers do best and get to the science of the life requiring, ultimate biohack of H2O! Let's begin with hacking the untruths, and target the big one. There is NO proof or reason to have 8 cups of water each day. Yep, I said it. In fact, there has been multiple studies done proving this is illegitimate! In reality, there are too many variables that effect hydration requirements such as weight, gender, activity levels, what/how much you have eaten, heat, and heart or kidney pathologies just to name a few, so no one amount will work for even half of the population. The Committee at the Institute of Medicine even states that “While it might appear useful to estimate an average requirement (an EAR) for water, an EAR based on data is not possible”  There are 2 easy guidelines to account for this and the first is quite simple. If you are thirsty or active, you should drink some water. You can over do it, but it takes a lot to do so. Again, everyone is different, but typically after a gallon or so within 2-3 hours is too much for almost everybody and can cause some acute health issues. At that point you almost literally have to force water down your throat which brings us to guideline number 2; if you're drinking and it becomes physically difficult to drink water, you've probably had enough. We have a reflex that slows down our swallowing strength when we are over full of food and fluids, so as always, listen to your body, it knows best. Also, our bodies can only absorb about a quart an hour, so even if you are in heavy exercise, any more than that is going in and straight out without any benefit anyway other then depleting your body of more salt and electrolytes. The next myth to bust is that caffeine dehydrates you, so here you go, it doesn't. Well not if you're used to drinking it, and it only minimally does if you are a caffeine novice. Moderate amounts of caffeine usage (4 cups of coffee or 100mg of caffeine) showed no significant diuretic effects leading to lower hydration levels. This is not to be confused with saying that coffee and water are equal, as caffeine does lower our bodies' salt levels and does not give all the same effects as water which will be covered down the page.  ​Based on the most current research, increasing water intake alone also DOES NOT provide the following benefits as many have proclaimed; healthier and shinier skin, better kidney functions, clearing out toxins, and giving more energy. These were all thought up by one industry or another to help promotions and as far as could be found, held no scientific support. So what does drinking water help with? Still quite a bit, I mean it is necessary for a reason! Staying hydrated is great for both physical and mental performance. Muscle is 80% water, so staying fully hydrated helps prevent early muscle fatigue, cramping, and may allow for an extra rep or 2 in the gym. Also when dehydrated, our bodies release less anabolic hormones and more catabolic hormones including cortisol, so having sufficient water levels may help with exercise gains. Though these effects of dehydration effect all activities, it appears that it hampers high intensity and endurance activities like long distance running significantly more than anaerobic ones like weight lifting. ​ Being dehydrated, also can effect short term memory, focus, visual perception, and other cognitive factors. Both these and the physical decreases can occur once someone has lost as little as 2% of weight from water such as sweating. This would be about 3lbs for someone weighing initially 150lbs, and it's not uncommon for many athletes to lose 6-8% in any given workout. Drinking water can also help with weight loss, and this is 2 fold. First the simple mechanism; drinking 500ml of water (around 16 oz) before a meal helps with satiety and forces us to eat less. However, there is more to it then that. The same amount also is shown to increase metabolic rate by roughly 30%. This increase in metabolism begins in only 10 minutes and peaks after about 30-40 minutes and can last up to 3 hours. So you can burn a few extra calories a day just by staying hydrated; sounds worth-while to me.  Even if water doesn't hold up to all the “facts” that many of us have heard time and time again, it is still the item which should be consumed the most by everybody on any given day. With all the benefits mentioned, let alone the thousands of physiological reactions it helps with in the body, I say bottoms up with the bottle to good health! References: ​ Boschmann, Michael, et al. “Water Drinking Induces Thermogenesis through Osmosensitive Mechanisms | The Journal of Clinical Endocrinology & Metabolism | Oxford Academic.”OUP Academic, Oxford University Press, 1 Aug. 2007, academic.oup.com/jcem/article-lookup/doi/10.1210/jc.2006-1438.​ Killer, Sophie C., et al. “No Evidence of Dehydration with Moderate Daily Coffee Intake: A Counterbalanced Cross-Over Study in a Free-Living Population.” PLOS ONE, Public Library of Science, journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0084154.  Popkin, Barry M., et al. “Water, Hydration and Health.” Nutrition Reviews, U.S. National Library of Medicine, Aug. 2010, www.ncbi.nlm.nih.gov/pmc/articles/PMC2908954/.  University of Michigan. Myth of 8 Glasses of Water a Day. 24 Aug. 2015, www.med.umich.edu/1libr/Gyn/ObgynClinic/8GlassesWaterMyth.pdf.  “What Is Hyponatremia?” WebMD, WebMD, www.webmd.com/a-to-z-guides/what-is-hyponatremia#1.   biohackhumans.com   Find us: Instagram (@biohackhumans)  Facebook (@biohackhumans) Twitter (@biohackhumans) Tumblr (@biohackhumans)   Contact Us: support@biohackhumans.com

In this VETgirl online veterinary continuing education podcast, we interview Dr. Alicia Niedzwecki, DACVECC, on a recent study that she performed entitled Effect of oral 3% hydrogen peroxide used as an emetic on the gastroduodenal mucosa of healthy dogs. In this study, Dr. Niedzwecki performed a prospective study aimed to investigate the effects of 3% hydrogen peroxide on the gastrointestinal mucosa in healthy dogs when ingested in amounts we routinely use for emesis induction. What'd they find? Maybe we shouldn't be using hydrogen peroxide in our veterinary poisoned canine patients after all, as evidence of esophagitis, gastritis and gastric ulceration can be seen. This study supports that hydrogen peroxide is not as benign as perhaps we once thought. While the authors' take away from this study was that the use of hydrogen peroxide shouldn't be recommended for at-home use in pet owners unless the benefits outweigh the risks, the toxicologist in me is going to take a little bit of a different take on it. VETgirl will likely still use it as an emetic agent (again, only in dogs), but now I'm going to add on gastric protectants and antacids for 1-2 weeks post-administration of hydrogen peroxide.

In this VETgirl online veterinary continuing education podcast, we interview Dr. Alicia Niedzwecki, DACVECC, on a recent study that she performed entitled Effect of oral 3% hydrogen peroxide used as an emetic on the gastroduodenal mucosa of healthy dogs. In this study, Dr. Niedzwecki performed a prospective study aimed to investigate the effects of 3% hydrogen peroxide on the gastrointestinal mucosa in healthy dogs when ingested in amounts we routinely use for emesis induction. What'd they find? Maybe we shouldn't be using hydrogen peroxide in our veterinary poisoned canine patients after all, as evidence of esophagitis, gastritis and gastric ulceration can be seen. This study supports that hydrogen peroxide is not as benign as perhaps we once thought. While the authors' take away from this study was that the use of hydrogen peroxide shouldn't be recommended for at-home use in pet owners unless the benefits outweigh the risks, the toxicologist in me is going to take a little bit of a different take on it. VETgirl will likely still use it as an emetic agent (again, only in dogs), but now I'm going to add on gastric protectants and antacids for 1-2 weeks post-administration of hydrogen peroxide.

The PRS Journal Club and special guest moderator Dr. Michael Zenn to discuss the following articles from the August 2017 issue: “Male-to-Female Sex Reassignment Surgery Using the Combined Technique Leads to Increased Quality of Life in a Prospective Study” by Dr. Papadopoulos. “Extended Transconjunctival Lower Eyelid Blepharoplasty with Release of the Tear Trough Ligament and Fat Redistribution” by Dr. Chin-Ho Wong. "Simplifying the Forehead Flap for Nasal Reconstruction” by Dr. Sanniec.

In today's show we start with a little Paleo Diet satire, and then we talk about: studies that say intermittent fasting is great for weight loss but could also lead to an increased chance of heart disease. Find out why Naked Juice isn't claiming to be "all-natural" anymore. We also discuss stem-cell beef, which is making it's debut soon. In the Moment of Paleo segment, I answer some questions like "What is Paleo?" and "What does Humans are not Broken mean?" After the Bell, we've got a fantastic real-food clip featuring Michael Pollan. Links for this episode:John Harris' Paleo Diet System - YouTubeTwo-Day Diets: How Mini Fasts Can Help Maximize Weight Loss : The Salt : NPRSkipping breakfast may be healthy way to lose weight for some - CBS NewsSkipping Breakfast: Is it Really the Most Important Meal of the Day?Skipping breakfast may increase heart attack risk, study finds | Science RecorderProspective Study of Breakfast Eating and Incident Coronary Heart Disease in a Cohort of Male US Health ProfessionalsPepsiCo Naked Juice to Drop ‘All Natural’ After $9 Million LawsuitPepsiCo’s Naked Juices Have to Drop ‘All Natural’ Label After $9 Million Class Action Lawsuit | NationofChangePepsiCo to no longer call Naked juices 'natural'$320,000 lab-grown burger due for a high-profile tasting in August - NBC News.comDutch researchers grow world's first test tube hamburger - YouTubeMichael Pollan on How Reclaiming Cooking Can Make Us Healthy - YouTubeHumans Are Not Broken - Angelo's BlogThe Latest in Paleo Community on Facebook - Post a link or just say hi!

MDS presents the latest research and findings from the field of Movement Disorders. Abstracts of articles from the Society Journal, Movement Disorders, are taken from the February 2013 (Vol. 28, Issue 2) issue.

Introduction: Isotonic crystalloids play a central role in perioperative fluid management. Isooncotic preparations of colloids (for example, human albumin or hydroxyethyl starch) remain nearly completely intravascular when infused to compensate for acute blood losses. Recent data were interpreted to indicate a comparable intravascular volume effect for crystalloids, challenging the occasionally suggested advantage of using colloids to treat hypovolemia. General physiological knowledge and clinical experience, however, suggest otherwise. Methods: In a prospective study, double-tracer blood volume measurements were performed before and after intended normovolemic hemodilution in ten female adults, simultaneously substituting the three-fold amount of withdrawn blood with Ringer's lactate. Any originated deficits were substituted with half the volume of 20% human albumin, followed by a further assessment of blood volume. To assess significance between the measurements, repeated measures analysis of variance (ANOVA) according to Fisher were performed. If significant results were shown, paired t tests (according to Student) for the singular measurements were taken. P < 0.05 was considered to be significant. Results: A total of 1,097 +/- 285 ml of whole blood were withdrawn (641 +/- 155 ml/m2 body surface area) and simultaneously replaced by 3,430 +/- 806 ml of Ringer's lactate. All patients showed a significant decrease in blood volume after hemodilution (-459 +/- 185 ml; P < 0.05) that did not involve relevant hemodynamical changes, and a significant increase in interstitial water content (+ 2,157 +/- 606 ml; P < 0.05). The volume effect of Ringer's lactate was 17 +/- 10%. The infusion of 245 +/- 64 ml of 20% human albumin in this situation restored blood volume back to baseline values, the volume effect being 184 +/- 63%. Conclusions: Substitution of isolated intravascular deficits in cardiopulmonary healthy adults with the three-fold amount of Ringer's lactate impedes maintenance of intravascular normovolemia. The main side effect was an impressive interstitial fluid accumulation, which was partly restored by the intravenous infusion of 20% human albumin. We recommend to substitute the five-fold amount of crystalloids or to use an isooncotic preparation in the face of acute bleeding in patients where edema prevention might be advantageous.

A PTJ podcast titled "Use of the Berg Balance Scale for Predicting Multiple Falls in Community-Dwelling Elderly People: A Prospective Study."

Background: To establish an efficient prophylaxis of coronary artery disease reliable risk stratification is crucial, especially in the high risk population of patients suffering from diabetes mellitus. This prospective study determined the predictive value of coronary calcifications for future cardiovascular events in asymptomatic patients with diabetes mellitus. Methods: We included 716 patients suffering from diabetes mellitus (430 men, 286 women, age 55.2 +/- 15.2 years) in this study. On study entry all patients were asymptomatic and had no history of coronary artery disease. In addition, all patients showed no signs of coronary artery disease in ECG, stress ECG or echocardiography. Coronary calcifications were determined with the Imatron C 150 XP electron beam computed tomograph. For quantification of coronary calcifications we calculated the Agatston score. After a mean observation period of 8.1 +/- 1.1 years patients were contacted and the event rate of cardiac death (CD) and myocardial infarction (MI) was determined. Results: During the observation period 40 patients suffered from MI, 36 patients died from acute CD. The initial Agatston score in patients that suffered from MI or died from CD (475 +/- 208) was significantly higher compared to those without cardiac events (236 +/- 199, p < 0.01). An Agatston score above 400 was associated with a significantly higher annualised event rate for cardiovascular events (5.6% versus 0.7%, p < 0.01). No cardiac events were observed in patients with exclusion of coronary calcifications. Compared to the Framingham risk score and the UKPDS score the Agatston score showed a significantly higher diagnostic accuracy in the prediction of MI with an area under the ROC curve of 0.77 versus 0.68, and 0.71, respectively, p < 0.01. Conclusion: By determination of coronary calcifications patients at risk for future MI and CD could be identified within an asymptomatic high risk group of patients suffering from diabetes mellitus. On the other hand future events could be excluded in patients without coronary calcifications.

Although atypical antipsychotics are on the rise, traditional treatment of psychotic (or delusional) depression mostly includes the addition of classical antipsychotics to antidepressants. As there are only few data supporting this approach compared with antidepressant monotherapy, and almost no data comparing it with antidepressants of the latest generation, we conducted a retrospective chart analysis and a prospective, randomized open study on the efficacy and tolerability of nefazodone monotherapy versus combined treatment with amitriptyline and haloperidol in psychotic depression. The results suggest that the addition of classical antipsychotics should be reserved for those with very severe psychotic symptoms, but may not be needed in milder forms. Copyright (c) 2003 S. Karger AG, Basel.

Fri, 1 Jan 1993 12:00:00 +0100 https://epub.ub.uni-muenchen.de/9823/1/stief_christian_9823.pdf Schneider, B.; Jonas, Udo; Stief, Christian Georg; Gonnermann, O.; Liedke, S. G.; Allhoff, E. P.

Editor-in-Chief, Robert Amdur, MD, reviews the evidence for treating Low-Intermediate Risk prostate cancer with Ultra Hypofractionated SBRT. This discussion was stimulated by a paper published in the November/December 2023 issue of PRO titled “Long-Term Outcomes of a Prospective Study on Highly Hypofractionated Intensity Modulated Radiation Therapy for Localized Prostate Cancer for 3 Weeks” with PMID 37414247. However, the majority of the podcast will focus on data supporting 5 Fraction SBRT, including the most recent report from the PACE-B trial (Abstract only from the 2023 ASTRO annual Meeting).