Podcasts about Eau

En Italie, entre sécheresse et violentes intempéries, le nord en particulier, est touché par des phénomènes climatiques extrêmes. Mais après plus d'un an de sécheresse historique qui a marqué le Piémont, décrétée en état d'urgence, de fortes précipitations se sont abattues sur la région de Turin où le grand fleuve Pô prend sa source. Du manque criant d'eau à son abondance parfois dévastatrice, les bouleversements météo soudains interrogent sur la gestion des ressources. ► À lire aussi : Inondations en Italie: comment les réseaux ont joué un rôle clé dans l'aide

durée : 00:02:42 - Les histoires du monde - par : Anthony BELLANGER - Le taux de sodium dans l'eau potable uruguayenne est deux plus élevé que celui conseillé par l'OMS. Et ce n'est pas un hasard !

durée : 00:02:42 - Les histoires du monde - par : Anthony BELLANGER - Le taux de sodium dans l'eau potable uruguayenne est deux plus élevé que celui conseillé par l'OMS. Et ce n'est pas un hasard !

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O Pedro Custódio saiu de Portugal em 2009, começou esta viagem em Singapura, passou pela Indonésia, EAU, Alemanha, Inglaterra e há 7 meses chegou à Malásia. 14 anos de gratidão.

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Au menu de l'actualité :

durée : 00:03:39 - Demain l'éco - par : Annabelle Grelier - Spécialisée depuis 18 ans sur le secteur de la récupération des eaux de toitures, cette entreprise girondine développe et installe des dispositifs de collecte et de filtration qui permettent aux collectivités locales et aux entreprises d'économiser jusqu'à 70% de leur besoin en eau potable.

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C dans l'air du 28 avril - Eau : déjà l'alerte ! LES EXPERTS : - Françoise Vimeux - Climatologue, directrice de recherches à l'Institut de recherche pour le développement - Esther Crauser-Delbourg - Economiste de l'eau - Philippe Dessertine - Directeur de l'Institut de Haute Finance, Le grand basculement - Célia Quilleret - Journaliste, spécialiste de l'environnement et des énergies – France Inter

LES EXPERTS : - Françoise Vimeux - Climatologue, directrice de recherches à l'Institut de recherche pour le développement - Esther Crauser-Delbourg - Economiste de l'eau - Philippe Dessertine - Directeur de l'Institut de Haute Finance, Le grand basculement - Célia Quilleret - Journaliste, spécialiste de l'environnement et des énergies – France Inter C dans l'air du 28 avril - Eau : déjà l'alerte ! Un gigantesque incendie dans l'État du New Jersey alors qu'une chaleur record s'installe dans le nord-est des Etats-Unis et comme l'année dernière à la même époque, l'Inde et ses voisins qui suffoquent. Une épisode caniculaire qui touche toute la partie sud de l'Asie, jusqu'en Thaïlande et au Laos, où les records de températures sont tombés, accablant une région qui abrite près de 2 milliards d'habitants, soit plus du quart de l'humanité et menaçant cette année encore les récoltes de céréales, notamment de blé. Conformément aux avertissements émis par les experts du GIEC, avec le réchauffement climatique, la fréquence des évènements extrêmes augmente, les vagues de chaleur se multiplient et sont plus longues. Dans le sud de l'Europe, au Portugal ou encore en Espagne, et plus particulièrement en Andalousie, le mercure atteint depuis plusieurs jours des températures comprises entre 38 °C et les 40 °C. En France des températures records ont aussi été enregistrées cet après-midi avec 27 °C à Bordeaux, 26 °C. à Tarbes, et vingt départements sont déjà concernés par une alerte sècheresse. Une pénurie d'eau qui inquiète notamment dans les Pyrénées orientales où des premiers feux de forêt majeurs ont eu lieu à la mi-avril et des villages sont déjà privés d'eau potable. Une situation d'autant plus alarmante que le préfet a averti mardi qu'en raison de la sécheresse exceptionnelle dans ce département, "il n'y aura pas suffisamment d'eau pour tous les usages" cet été, ce qui obligera à "des décisions difficiles". Il a décidé ce vendredi de placer le département en état de crise liée à la sécheresse - le plus haut niveau d'alerte possible - à compter du 10 mai. Mais comment vivre avec moins d'eau ? Face à la sécheresse, la France va devoir s'adapter dans l'urgence à la pénurie d'eau, et dans certaines communes, des élus locaux entendent remettre en question des procédés qu'ils jugent désormais obsolètes. C'est le cas à Grigny dans l'Essonne où le maire souhaite que l'entreprise Coca-Cola arrête de prélever de l'eau directement dans la nappe phréatique et se fournisse désormais auprès de la Régie publique de l'eau. DIFFUSION : du lundi au samedi à 17h45 FORMAT : 65 minutes PRÉSENTATION : Caroline Roux - Axel de Tarlé REDIFFUSION : du lundi au vendredi vers 23h40 RÉALISATION : Nicolas Ferraro, Bruno Piney, Franck Broqua, Alexandre Langeard, Corentin Son, Benoît Lemoine PRODUCTION : France Télévisions / Maximal Productions Retrouvez C DANS L'AIR sur internet & les réseaux : INTERNET : francetv.fr FACEBOOK : https://www.facebook.com/Cdanslairf5 TWITTER : https://twitter.com/cdanslair INSTAGRAM : https://www.instagram.com/cdanslair/

Depuis des siècles, l'Atlantide alimente les théories autant que les polémiques. Légende pour les uns, réalité pour les autres, cette île engloutie qui n'a jamais été retrouvée fut évoquée pour la première fois par Platon. Mais au-delà de la réalité historique de l'Atlantide, que nous apprend le récit de Platon sur le monde et sur nous-mêmes ? C'est ce que nous allons tenter de découvrir dans cet épisode. Vous pouvez nous soutenir : ★En devenant contributeur sur Patreon : https://www.patreon.com/leprecepteurpodcast Vous pourrez ainsi accéder à du contenu inédit ! ★Ou en faisant un don ponctuel sur PayPal : http://paypal.me/leprecepteurpodcast Pensez à laisser une note et un avis sur la plateforme de podcast où vous m'écoutez. Cela prend quelques secondes, et c'est un geste très utile pour le référencement du podcast ! Et bien sûr, continuez à partager les émissions que vous préférez sur vos réseaux sociaux. Le Précepteur Podcast a été créé pour vous et continuera d'exister grâce à vous. (Pour toute demande, vous pouvez contacter l'équipe du Précepteur Podcast ici : leprecepteurpodcast@gmail.com)

We've got some addictively delicious new launches to serve you this week, with a catch-up on what we've been wearing, and a dive into the postbag where answer your Perfume Prescriptions (including questions about fragrances to evoke the scents of freshly cut grass, and the smell of a dog's head…!) What We've Been Wearing…Nicola:@ffern.co Spring 21@ilapothecary Speak Your Truth / Beat the Blues (Aroma Rollers)@ilapothecary Feminine Happy Oil (body oil) https://www.ilapothecary.com Suzy: @akrofragrances Bake @givenchybeauty L'Interdit Édition Millésime Burning Neroli @ellisbrooklyn FloristListener Perfume Prescriptions: @zara Waterlily Tea Dress@loccitane_uk_ire Herbae@hermes Un Jardin Sur Le Toit@sisley Eau de Campagne @fredericmalle En Passant @guerlain L'Art & La MatiereCuir Beluga eau de parfum@allsaints Leather Skies@cleanbeauty_collective Clean Reserve Sueded Oud

Fallos del Hakuto-R, la Zhurong marciana y el cohete estudiantil N₂ORTH / Chromebooks abandonados / Ryzen Z1 para competir con Steam Deck / OpenAI quiere registrar la marca GPT Patrocinador: Vuelven los mejores amigos de tu descanso, porque en Morfeo.com tienen grandes rebajas. Se han venido arriba con 20% de descuento en sus mejores productos. Recuerda que el envío es gratuito y en 24 horas, y tienes 100 días de prueba sin compromiso. — No voy a parar hasta que todos los lectores de mixx.io tengáis uno.

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Ce lundi 24 avril, la coupure de l'eau et l'annulation du forage de deux nouveaux puits d'eau en Arizona pour une exploitation de luzerne destinée à l'Arabie Saoudite ont été abordées par Benaouda Abdeddaïm dans sa chronique, dans l'émission Good Morning Business, présentée par Pauline Ducamp et Christophe Jakubyszyn, sur BFM Business. Retrouvez l'émission du lundi au vendredi et réécoutez la en podcast.

Em 2010 a Ana Anjos fora para a Alemanha "por-se à prova". Ficou por lá 3 anos e "passou no teste". Em 2015 mudou-se para os EAU, divide-se entre o Dubai e Abu Dhabi e confessa-se surpreendida. Numa palavra, crescimento.

EAU, SÉCHERESSE : L'ALERTE GÉNÉRALE IRÈNE TOLLERET Viticultrice et députée européenne Renew Nous sommes au début du printemps et déjà certains territoires français sont en alerte sècheresse. Sur les 170 points noirs identifiés par l'exécutif, 48 se trouvent en Occitanie. Les fuites d'eau potable n'épargnent pas la région, alors même que plusieurs zones sont en vigilance, en alerte, voire en alerte renforcée avec des restrictions d'utilisation de l'eau pour faire face à la sécheresse. Dans les Pyrénées-Orientales, département d'Occitanie où la sécheresse est la plus inquiétante, des limitations d'utilisation de l'eau pour des fins agricoles sont en place, mais aussi pour l'arrosage des jardins, des espaces verts ou encore des golfs. Dans 48 communes et collectivités d'Occitanie, la moitié de l'eau potable n'arrive pas à destination à cause de fuites sur le réseau, contre 1 litre sur 5 ailleurs. Pour y remédier, fin mars, Emmanuel Macron a présenté son plan Eau pour améliorer la gestion de l'eau en France. L'objectif affiché est d'ici 2030 "de faire 10% d'économie d'eau dans tous les secteurs”, avec 5 grands axes de travail : accélérer la sobriété partout et dans la durée, lutter contre les fuites, investir dans la réutilisation d'eaux usées, accompagner la transformation de notre modèle agricole et mettre en place partout une tarification de l'eau. Parmi les annonces faites sur le plan Eau de l'exécutif, chaque secteur devra présenter un plan en sobriété sur l'eau d'ici à l'été. Pour atteindre ces objectifs, Emmanuel Macron a annoncé une hausse du budget des agences de l'eau, qui est de 2,2 milliards d'euros aujourd'hui, de "près de 500 millions d'euros par an". "C'est l'effort dont on a besoin pour déclencher au total environ 6 milliards de plus dans l'économie de l'eau chaque année", selon le chef de l'Etat. Pour Irène Tolleret, viticultrice et députée européenne Renew, il est plus que temps de sonner l'alerte. Le sujet de l'eau va s'accélérer, notamment en région Occitanie et région sud, qui seront vivement touchées par de nombreuses conséquences du réchauffement climatique. Irène Tolleret nous expliquera comment ces pénuries se traduisent dans les territoires et comment les agriculteurs peuvent s'adapter.

Des avancées en demi-teinte à la Conférence Mondiale sur l'eau…c'est ce que retient la presse française de la rencontre de New York, la première depuis près de 50 ans qui s'est tenue sous l'égide de l'ONU le mois dernier. Plus de 170 États et 10 000 personnes y ont participé. Un poste d'envoyé spécial de l'ONU pour l'eau douce n'a toujours pas été confirmé alors que contrairement à d'autres sujets qui préoccupent l'humanité, l'eau n'a pas au sein de l'ONU d'agence spéciale ni de fonds directement affectés. L'eau à l'échelle planétaire est sous financée et généralement mal connue. Sa présence, ses stocks, ses flux n'ont jamais fait l'objet d'un grand livre mondial de la connaissance. La crise de l'eau une crise si difficile à résoudre ?   Invités :   - Gérard Payen, vice-Président du Partenariat français pour l'eau, association qui rassemble les principaux acteurs privés et publics de l'eau.  - Patrice Fonlladosa, président du Thinktank (Re)sources. Ancien président Afrique du Médef. - Julien Ancele, directeur général de l'ONG 1001Fontaines dont la mission est de bâtir et déployer des solutions pérennes d'eau potable.  - Alain Boinet, Fondateur de l'ONG « Solidarités international » et fondateur du site internet Défis Humanitaires. 

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In this episode Suzy tells us all about her incredible experience at the Esxence, the huge fragrance fair in Milan. Nicola and Suzy also have a general life and fragrance catch up and we read some of your incredibly moving and life affirming messages.Here's what we mention during the episode:What we've been wearing…Nicola's been wearing:@penhaligon's_london Highgrove Bouquet @ormondejayne Levant Suzy's been wearing:@trudon Mortel@thameen Fanfare @maisoncrivelli Oud Maracuja*****Best of @esxenceofficial - Part One:@boujeebougies Eau de Boujees Queen, Verdant, GildedQueer2 NEW candles: Tart and Thorny (Sign up to their newsletter to hear when they're launched: https://boujeebougies.com) @lejardinretrouve Osmanthe Liu Yuan @ellakparfumsparis Musc K (coming out later this year)@electimusslondon celestially inspired fragrance by Christian Provenzano (coming later this year)@fdo_parfum Francesca dell'Oro Else@bel.rebel …& the pea@fugazzifragrances Cash Flower

durée : 00:06:02 - Ces chansons qui font l'actu - par : Bertrand DICALE - Alors que l'on découvre que des métabolites du chlorothalonil, un pesticide interdit depuis 2019, seraient présentes dans le tiers de l'eau du robinet en France, écoutons comment les artistes célèbrent les symboles de l'eau de la vie.

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durée : 00:04:29 - Le journal de presque 17h17 - par : Charline Vanhoenacker, Alex Vizorek - Elisabeth Borne appelle à une période de convalescence sur la réforme des retraites, le dernier livre d'Éric Zemmour se vend quatre fois moins bien que son précédent et l'Insee a publié une étude qui montre que la France compte 30 000 centenaires, c'est l'actu du jour !

Suzy recorded this episode in scented snippets while visiting the @esxenceofficial trade fair in Milan. A showcase and meeting point for press, niche perfumery, retail buyers and distributors, this was the place to be (and sniff!) not only for what's happening in the fragrance world right now, but what we can look forward to finding out more about in the future. Suzy spoke to Pia Long @piamoomin - perfumer and Co-Founder (with @nickrgilbert) of @olfiction, and the brand @boujeebougies…. Who were showing their new FRAGRANCES, ‘Eau de Boujees' and two new candles (and new vessels!) Incredibly excitingly, Suzy even had something to do with one of the fragrances!@manos_getakinis was the next fragrant chat captured here - learning of his new limited edition fragrance, Citrine, and rhapsodising about the delicious MEΘEXIS. We do wish there were time to record everything that happened at the fair (well maybe not *everything*) but we'll catch up with further insights and more in-depth interviews in future discussions on the show. Meanwhile, we hope you enjoy this sneak peek into the perfume world…

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durée : 00:20:09 - Journal de 18h - Ressource de plus en plus rare, l'eau doit être économisée, réutilisée, et payée plus cher en cas de consommation de confort. Ce sont quelques uns des messages délivrés par Emmanuel Macron, qui a lui-même présenté le plan Eau du gouvernement.

Emmanuel Macron s'empare du sujet de l'eau et espère dépasser la crise des retraites. Il était en déplacement dans les Hautes-Alpes pour présenter son "plan eau". Un sujet qui pourrait devenir un enjeu idéologique après les violents incidents de Sainte-Soline. Le sujet des retraites se déplace sur celui de la violence avec une colère populaire qui reste forte.

Random Vegas When Wynn was building Bellagio, to pull in the kind of numbers he needed to make the place profitable, he knew he needed a show that would put people in the seats 6 days a week. So he went to Cirque and requested a production centered around water. Originally, it was going to be called Eau, the French word for water. However, people inside the organization were concerned that Americans would mispronounce it as “Eww”, so instead they went with the way it was pronounced, O.   Twitpic of the week  Holy...fuckin...shit. This week's winner, shared by @stratvegas is fucking epic. Come on, a desert icon like the Stratosphere in the foreground of an epic collection of snow covered mountains in the background is simply breath taking. Seriously, words are escaping me. Do yourself a favor and check this week's winner out. Simply stunning News Nightmare Las Vegas Wahlburgers 2: Wahlburgery Six: The Musical

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Il n'y avait pas eu de sommet mondial sur l'eau douce depuis 1977, c'est-à-dire 46 ans !!! Et les conférences sur le climat qui se succèdent régulièrement depuis plusieurs années en faisaient à peine état. Le changement climatique et ses manifestations diverses contribuent à la prise de conscience de l'importance de l'eau —question vitale pour l'humanité– alors même que des pays, comme ceux de l'hémisphère nord, généralement gâtés en pluie se retrouvent, cet hiver, avec des rivières totalement asséchées. Un jamais vu qui fait toucher du doigt le rapprochement des questions liées au climat de notre quotidien à tous, universellement. Le sommet mondial de l'eau se tiendra du 22 au 24 mars 2023 à New York. En 2015, les Nations unies avaient fixé un objectif de développement durable pour assurer, en 2030, l'accès universel à l'eau potable et aux services d'assainissement. 2030, c'est pratiquement demain. À ce jour, deux milliards de personnes n'ont pas un accès correct à l'eau potable. Et près de la moitié de la population mondiale ne bénéficie toujours pas d'un service d'assainissement satisfaisant. Les progrès sont trop lents. Le sommet de mars 2023 sera-t-il le bon ?      Invités :    Gérard Payen, vice-président du Partenariat français pour l'eau, association qui rassemble les principaux acteurs privés et publics de l'eau  Patrice Fonlladosa, président du Thinktank (Re)sources. Ancien président Afrique du Médef  Julien Ancele, directeur général de l'ONG 1001Fontaines dont la mission est de bâtir et déployer des solutions pérennes d'eau potable. 1 million de bénéficiaires    Alain Boinet, fondateur de l'ONG « Solidarités international » et fondateur du site internet Défis Humanitaires.

Dr. Scott Tagawa and Dr. Oscar Brouwer come on the ASCO Guidelines podcast to discuss the new EAU-ASCO Collaborative Guidelines on Penile Cancer. These comprehensive guidelines cover pathological assessment of tumour specimens, diagnosis and staging, local treatment of penile carcinoma, radical inguinal lymph node dissection, prophylactic pelvic lymph node dissection, surgical management, neoadjuvant and adjuvant chemotherapy, radiotherapy, systemic and palliative therapies for advanced penile cancer, follow-up, and quality of life. They highlight key recommendations, and describe the importance of a patient-focused and multidisciplinary approach to management of penile cancer. Find more information about the guidelines at www.asco.org/genitourinary-cancer-guidelines The full text of the guideline is available at https://uroweb.org/guidelines/penile-cancer    Conflict of interest disclosures: Guideline Working Group  Dr. Scott Tagawa  Dr. Oscar Brouwer TRANSCRIPT Brittany Harvey: Hello and welcome to the ASCO Guidelines Podcast, one of ASCO's podcasts delivering timely information to keep you up to date on the latest changes, challenges, and advances in oncology. You can find all the shows, including this one, at asco.org/podcasts.  My name is Brittany Harvey, and today I'm interviewing Dr. Oscar Brouwer from the Netherlands Cancer Institute in Amsterdam, and Dr. Scott Tagawa from Weill Cornell Medical College in New York, co-chairs on the ‘ASCO-EAU Collaborative Guidelines on Penile Cancer'.  Thank you for being here, Dr. Brouwer and Dr. Tagawa. Dr. Scott Tagawa: Thanks very much. Dr. Oscar Brouwer: Yeah, thanks for having us. Brittany Harvey: Before we discuss this guideline, I'd just like to note that the guideline was led by the European Association of Urology, and the conflict of interest disclosures of the Guideline Working Group are publicly accessible through the European Association of Urology website linked in the show notes. Additionally, Dr. Brouwer's and Dr. Tagawa's individual disclosures are provided in the show notes of this episode.  So, to jump into the content of this guideline, first, Dr. Tagawa, could you give us a general overview of the purpose and the scope of this collaborative EAU-ASCO Guideline? Dr. Scott Tagawa: So, I think the key word there is collaborative. This was truly a collaborative effort, and I say that in a number of ways. So, the two key organizations, the EAU and ASCO, came together with a Memorandum of Understanding and got together from the very beginning in terms of developing the scope and then throughout the methodology for the guidelines. And then, on a practical basis, I'd say even more importantly, a collaboration between multiple physicians of different disciplines from across the world. Whether we're talking about surgeons, radiation oncologists, medical oncologists, pathologists, we had panel members from all over the world as well as patient representatives from all over the world. And patient representatives really played a key role in the development of this guideline.  By way of background, penile cancer in most places is considered a rare disease. For example, in the United States, we expect around 2000 cases per year. In the genitourinary world, the next rare cancer is going to be testis cancer, which is going to be four or five times higher than that per year and nowhere near prostate cancer, for instance. So, just kind of put that into perspective. But, importantly, a disease that is a worldwide issue in a number of different ways. That includes the kind of general stigma of being diagnosed with that, the physical and emotional consequences of the diagnosis, as well as treatment. And then, because in part of its rarity, the lack of prospective randomized trials to really guide clinicians and that, I would say, that total package underscores the importance of coming together with a guideline. Brittany Harvey: Great. Thank you for providing that background and perspective.  So then, next, Dr. Brouwer, I'd like to review the key recommendations of this comprehensive guideline. Starting with what are the key recommendations regarding diagnosis and staging of penile cancer? Dr. Oscar Brouwer: First of all, I guess just to underline what my colleague, Dr. Tagawa, just said, it's a worldwide guideline, international, multi-continental. I think that's quite a special thing. But it also poses a few challenges, of course, because cultural differences and treatments may differ, opinions as well, distances that patients have to travel, lots of factors there, and also economy, et cetera, et cetera. So, to find a consensus there has been one of the challenges. I think we did a good job there to really make it accessible to all patients and physicians, of course, in the world.  When talking about diagnosis, I think comparing our new guidelines to old guidelines really emphasizes the new 2022 WHO classification in which distinction between HPV-positive and HPV-negative disease is highlighted. We increasingly have some knowledge on the difference between the HPV-related and the non-HPV-related penile cancers. I'd say it's about 50-50, the distinction. So, 50% is HPV-related, and 50% not HPV-related. But what we know from other cancers, for instance, that HPV-positive disease is associated with better prognosis than HPV-negative. This distinction is not so clear in penile cancer yet. And one of the reasons is just the lack of data, a lack of perspective for large studies, so to say. So, what we're really highlighting and underlining in the new guideline is the importance of doing HPV testing in all patients that have penile cancer, and that tissue is taken from. We chose to go for the cheapest and easiest but reliable methods to do so. So, immunohistochemistry of p16, to be exact. This is one of the important, I think, recommendations, or maybe even more than a recommendation; obligations we set to all physicians treating penile cancer.  So, just in terms of diagnosis and in terms of staging, we all know that lymph node status is the most important factor determining survival. So, finding those lymph nodes, if they are involved with cancer, yes or no. So, if they are metastatic, yes or no, is of crucial importance. This has always been the case, but I think it cannot be emphasized enough. And in this new guideline, we again emphasize the importance of doing surgical lymph node staging in high-risk patients. And what's a little bit new is that we are more or less going to the direction of preferring central node biopsy as the best method to do so. You could also, of course, remove all the lymph nodes, what we call radical lymph node dissection. It's still possible inside our new recommendations, depending on availability of all the techniques or availability of expert centers in proximity. But I think we can all see that in terms of complication rates, central node biopsy is probably superior. So this is also one of the new things in terms of staging.  Brittany Harvey: Absolutely. Thank you for those highlights of diagnosis and staging in the guideline.  So, following those recommendations, Dr. Tagawa, and I know this is a large section, but what does the expert panel recommend for disease management of penile cancer? Dr. Scott Tagawa: A single-sentence summary would say a multi-disciplinary approach in an expert center when possible. Re-emphasizing one of the statements that Dr. Brouwer made about sentinel lymph nodes; it appears to be better, but clearly is not available everywhere. And if I just make this US-centric for a minute, just within this country, where there are centers that are able to do it and have that expertise, there are centers that are not so far away that may not be able to do that. So regional differences within a single country that's what happens. So, anyway, multi-disciplinary input, I think, is important for many diseases, including penile cancer. A little bit of a segue, but one part of this guideline of which most of us are proud is that, front and center really, the introductory paragraph of the guidelines, where it really states that we need to really have this disease and the management patient-focused and that includes addressing some of the emotional aspects of the disease. Those are included in the management. But to kind of go through very quickly on a very high level, in the early stages management is mostly in the hands of the urologist. But sometimes there's dermatologists and others, so when there is superficial disease, we talk about superficial therapy and I'm just going to leave it at that, many of them don't have level 1 evidence, but there is, for instance, topical chemotherapy that can be helpful.  And then, as the disease becomes more invasive, so does the treatment. So there's sections on organ or penile sparing that is a reasonable option that needs to be done in a good multi-disciplinary system. That is a good and sometimes a preferred option when there is adequate staging for earlier stage disease. And then the more invasive the disease becomes is when the management needs to become more multi-disciplinary both in terms of workup as well as treatment. Where there is a consideration for, in certain situations, particularly in very locally advanced where it becomes unresectable at least in some eyes, where we say, “Okay, we're actually going to recommend starting off with chemotherapy,” the intent is for surgery with an alternative of chemotherapy and radiation. And currently, there are no head-to-head trials, but those are both reasonable approaches for the most locally advanced disease setting.  Taking a step back, if someone starts off with a little bit less locally advanced, so we'd say the alias, gross resectable, we would at least discuss in a multi-disciplinary setting what are the risk benefits of then post-operative therapy, whether that is radiation or chemotherapy, or both. I think all patients at least deserve the opportunity to have that discussion, and then that would be on an individual basis whether we decide to do that or not. Coming from the medical oncology-centric viewpoint where we really deal with systemic therapy, we don't really have any randomized trials to say that one approach is preferred to another, so they're kind of generic. But it does look like platinum chemotherapy, taxane chemotherapy are the most active current drugs. So when we're looking at multi-agent therapy when the setting is a goal of cure, we're generally saying platinum plus taxane combinations without being specific about doublets or triplets. Triplets when they can handle them, but not everyone can handle them.  And then for metastatic disease whether it's current or at presentation metastatic disease, the old guidelines actually said ‘don't even bother', but now that we have some effective drugs, we would say that for palliative purposes to come in with systemic chemotherapy, the same drugs that we talked about before. And then, there may be additional therapeutic agents. So we're now in the genomic era where there has been at least an initial look at what are the genomics of HPV related, non-HPV related, and there may be some targets, we just are a little bit too early to say that there are absolutely some targets, but there definitely are recommendations for participating in clinical trials. There are some trials that are specific to penile cancer. There are other ones that are non-specific or basket trials. Let's say any disease that has EGFR positivity, a patient with penile cancer may be able to get into that clinical trial or maybe meet a therapy-based trial, so considerations for the trials, I think, are important.  Brittany Harvey: It sounds like multidisciplinary care is a key tenet of this guideline. You mentioned patient-focused care is also key in this guideline. So that leads nicely into my next question. But Dr. Brouwer, what are the key recommendations both for follow-up and quality of life?  Dr. Oscar Brouwer Yeah so we have, like Dr. Tagawa already said, we have quite an elaborate section, not only in the introduction of the guideline but also a separate chapter at the end, really, to acknowledge the psychosocial, sexual impact this disease can have on patients. And again, I think it's more or less a plea for a form of centralized care for such a rare disease. We have a set of recommendations that we give in terms of follow-up and quality of life, and mainly several points that should really be discussed with patients, and support should be offered. So things like psychological sexual help, but also lymphedema therapist, physiotherapy in terms of complication management. And this mainly goes for patients that undergo lymph node surgery or treatment. And in our experience, if you don't see the disease often enough, you don't have all these things in place in your hospital to offer dedicated people that can do this. So I think that's something to consider in the future for healthcare in general when treating rare diseases such as these. But, yeah, like Dr. Tagawa said, our patient representatives have had a big role in this, and we're happy with that. So I recommend everyone to read it. Brittany Harvey: Absolutely. You've both mentioned that this is a rare disease. So, in your view, Dr. Tagawa, what is the importance of this guideline, and how will it impact clinicians? Dr. Scott Tagawa: There are certain centers that have high volume and certain countries that will have a high volume. For instance, areas in Brazil have a high volume. Whether there's a high volume or a low volume, like an average center in the United States, there haven't been any recent guidelines out there from any organization. So, the EAU has had an old guideline that was really out of date - updating that, number one. And number two, having the backing of two major organizations in the EAU and ASCO, I think is quite important to get this out there on a true international basis. Because not just in this disease, but in most diseases, when there is standardization of care, there's overall better outcomes, whether it's at the center that sees a lot or the centers that rarely see any. I think this document provides guidance, and, actually, take a step back for those that are interested, on the EAU website will be the entire very comprehensive guideline. So, someone that wants to get a lot of details, it's there, very comprehensive and honestly long, but it's, I think, an excellent reference document. And then, published in European Urology will be the summary guideline that has all the key points of the guidelines and summary in the text that will refer to the overall guideline for someone that wants to get through it on a quicker basis. That will also be published on the ASCO website just to kind of get that out there. A little bit of the side in terms of answering your question is that this is a rare tumor. We want everyone to have access to the best care possible, and if nothing else, it provides guidance in a setting where most clinicians don't have a lot of expertise. Brittany Harvey: Definitely. And thank you for highlighting both the summary and full text of the comprehensive guideline. We'll provide those links in the show notes, too, for easy access for any listeners.  And then, finally, you've both mentioned the impact this has for patients. But Dr. Brouwer, in your view, how will these guideline recommendations affect patients with penile cancer?  Dr. Oscar Brouwer: Well, of course, it's our hope that it will be very beneficial for patients around the world. I think it cannot be emphasized enough that this initiative, in which ASCO, in this case United States group, has collaborated with the European one to make an international multi continental guideline, is quite rare, in urological cancers is the first one. I'm not even sure if there are many others like these. I do really believe it makes sense for rare diseases to not have several guidelines. It's confusing which guideline to choose, especially if there are contradictions. So I guess this initiative is the first step towards having more comprehensive, literal guidelines for such a rare disease. And I really do hope that it will help clinicians, especially when they don't have experience treating this disease, to really look at this guideline first. And in turn, of course, I hope that will benefit patients because they'll have, hopefully, access to better quality care that way. And especially, like we already touched upon, also the importance of early access to support and to palliative care throughout the whole disease process. I really hope that is something that will be offered to patients worldwide more frequently now because it is not only about treating the disease itself but also about the consequences, of course. And I really do think that people will benefit from that in terms of quality of life. Brittany Harvey: Absolutely. I want to thank you both so much for your work on this comprehensive EAU-ASCO Guideline and for talking with me today and sharing your insights, Dr. Brouwer and Dr. Tagawa. Dr. Scott Tagawa:  Thank you very much. It was a pleasure. Dr. Oscar Brouwer: You're welcome. I would just like to add also a short opportunity, maybe just to thank all the panel members because it has been a huge effort. Not only an update, it has been actually rewritten from the ground up. So a lot of panel members, not only from the United States and Europe but also Canada, South America, patient representatives, all the associates that have helped. So it has been a big effort, and I congratulate and thank everyone. And thank you, Brittany, for the interview. Brittany Harvey: Definitely, it was a large group and multidisciplinary effort. So thank you to them as well. And also, thank you to all our listeners for tuning in to the ASCO Guidelines Podcast. To read the full guideline, go to www.asco.org/genitourinary-cancer-guidelines. I also encourage you to check out the companion episode on this guideline from EAU podcasts, which you can find on Apple Podcasts, Google Podcasts, and Spotify. You can also find additional ASCO guidelines and interactive resources in the free ASCO Guidelines app available in the Apple App Store or the Google Play store. If you have enjoyed what you've heard today, please rate and review the podcast and be sure to subscribe, so you never miss an episode.  The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement.    

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A l'Assemblée générale des Nations Unies et à l'initiative de son Président Csaba Kőrösi, une réunion d'information scientifique a donné lieu récemment à un débat entre éminents scientifiques et universitaires autour de la question des coopérations et des conflits dans le domaine de l'eau.Makane Moïse Mbengue était l'un des intervenants. Juriste expert dans le domaine de l'eau, il est l'un des partisans les plus fervents d'un meilleur usage de la science, des données scientifiques, dans les négociations internationales sur l'eau.Le prochain sommet de l'ONU sur l'eau qui se tiendra à New York du 22 au 24 mars mettra en avant la science comme un outil de la gouvernance de l'eau. Cette conférence permettra ainsi de rassembler des participants de tous les secteurs pour créer une dynamique efficace et aborder les principaux défis liés à la bonne gouvernance de l'eau en lien avec le Programme de développement durable à l'horizon 2030. ONU Info a rencontré Makane Moïse Mbengue. Il déplore dans cet entretien que la science soit le parent pauvre de la diplomatie de l'eau. Entretien : Makane Moïse Mbengue, professeur de droit international à la Faculté de droit de l'Université de Genève et Directeur du Département de droit international et organisation internationale.Entretien réalisé par Philippe CostePrésentation : Florence Westergard et Philippe CosteMixage : Florence Westergard 

Ce mardi 28 février, la sécheresse à l'épreuve de la théorie économique et des expériences passées, comment compenser des années de sous-investissement, la situation des entreprises françaises en Russie, et la fin des négociations commerciales, ont été abordés par Emmanuel Combe, économiste et ancien vice-président de l'Autorité de la concurrence, Robin Rivaton, directeur général de Storial et fondateur de Real Estech, et Laurent Vronski, directeur général d'Ervor, dans l'émission Les Experts, présentée par Nicolas Doze sur BFM Business. Retrouvez l'émission du lundi au vendredi et réécoutez la en podcast.

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Drop 1: Digital Yen https://www.japantimes.co.jp/news/2023/02/17/business/boj-digital-yen-pilot/ Drop 2: Polygon zkEVM https://beta.polygon.technology/blog/to-ethereum-with-love-announcing-polygon-zkevm-mainnet-beta-on-march-27th Drop 3: NFTs no SuperBowl https://www.adweek.com/brand-marketing/blockchain-gaming-startup-offers-10000-nfts-in-a-super-bowl-ad/.. More: Banco do Brasil permite pagamento de impostos usando cripto https://cointelegraph.com/news/brazil-s-oldest-bank-allows-residents-to-pay-off-tax-bill-with-crypto Banco Central dos EAU lança programa de transformação da infraestrutura financeira, inclui CBDC https://www.thenationalnews.com/business/banking/2023/02/12/uae-central-bank-launches-programme-to-boost-digital-transformation-in-financial-services/ FoxBit lança Earn, seu serviço de staking para 15 criptos https://valor.globo.com/google/amp/empresas/criptomoedas/noticia/2023/02/13/foxbit-lanca-servico-de-staking-para-15-criptoativos.ghtml DBS HK cripto trading https://cointelegraph.com/news/dbs-bank-to-offer-cryptocurrency-trading-in-hong-kong/ Regulador de ativos virtuais de Dubai apresenta novo conjunto de regras de gestão de risco e AML https://www.finextra.com/pressarticle/95755/dubai-constructs-virtual-assets-framework Siemens emite título de 60m EUR on-chain https://www.ledgerinsights.com/siemens-digital-bond-blockchain/ Ministério da Fazenda, Banco Central e CVM preparam decreto sobre criptomoedas https://cointelegraph.com.br/news/exclusive-ministry-of-economy-central-bank-and-cvm-prepare-decree-on-cryptocurrencies Fundador do ChatGPT vai lançar sua própria cripto https://www.moneytimes.com.br/criador-do-chatgpt-ira-distribuir-globalmente-sua-propria-criptomoeda-em-2023/ SoftBank entra como validador na rede Oasys, para games https://techcrunch.com/2023/02/16/softbank-joins-game-focused-blockchain-oasys-as-validator/ Figure e NovaWulf vão reestruturar o portfólio da Celsius com Provenance Blockchain https://www.prnewswire.com/news-releases/figure-partners-with-novawulf-to-provide-blockchain-technology-solutions-for-proposed-celsius-reorganization-301749443.html OpenSea reage a concorrência da Blur baixando taxas e royalties para artistas https://twitter.com/opensea/status/1626682043655507969?t=W3CmtDltIKn-MC6VNuR6hA&s=19 .. Meu conteúdo em inglês https://bi.11fs.com/ Me sigam em blockdrops.lens --- Send in a voice message: https://anchor.fm/blockdropspodcast/message

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Chaque mois, l'équipe de « Timeline, 5.000 ans d'Histoire » vous concocte un dossier thématique, divisé en capsules quotidiennes de 5 minutes. Pour les grands comme les plus petits, passionnés ou intéressés, ces dossiers vous permettront d'en apprendre plus sur les 5.000 ans qui font l'Histoire. « 5 minutes d'Histoire » est donc un vrai complément à la grande émission hebdomadaire, que nous sommes heureux de vous proposer désormais. Ce mois-ci, les Gallo-Romains.

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L'eau a un rôle incontournable pour permettre d'atteindre tous les Objectifs de développement durable (ODD). Ainsi un outil Water4allSDGs.org permet d'évaluer les contributions de politiques publiques ou de projets, en conformité avec les 17 Objectifs de développement durable.Philippe Guettier est conseiller au Partenariat français pour l'eau (PFE) et président de SDG Champions France. Il explique que cette application permet de voir, d'identifier et de regarder si un projet dans le domaine de l'eau permet ou pas d'atteindre les ODDs et leurs169 cibles.Entretien réalisé par Aleyna, Nina et ManonTechnique : LucieEco Radio est la webradio du Collège Vincent Van Gogh de Blènod-les-Pont-à-Mousson en France. Elle est membre du réseau des écoles associées de l'UNESCO.

This episode is a total banger. Sarah and I talk about all the things that get me good and fired up! Travel, unnecessary suffering in business, why the news is crap and so much more. It might sound like a string of random tangents, but there's a common thread in it all—creating success in a way that brings you joy and ease. Listen now. Can't-Miss Moments From This Episode:When Sarah was starting up her tourism business in 2007, she was oblivious to the looming recession… and turns out, that was a genius strategy! Here's why ignorance really is bliss (and the foundation for fighting a doom-and-gloom outlook). Things I want a t-shirt or mug version 45: You don't have enough time to make all the mistakes, so might as well learn from someone else's mistakes! It ain't mean-spirited, baby doll (psst… I bet you have some oopsies that could help a homie out, too). Nickel-and-diming yourself to death: why building your business on “affordability” is a losing strategy. Here's how Sarah increased her revenue and cut her work in half by adding higher ticket offers…  Ooo! What's that aroma? Why it's Eau de Desperation! Real talk—desperation is a stinky cologne, and unfortunately you can't always smell it when you're wearing it. You can't shower it off, but there's a “mind scrub” that'll have you smelling so fresh and so clean (and so attractive to new clientele).  Busy work vs business work: how to tell whether you're hopping on the hamster wheel or taking real needle-moving action. (Before you buy that next course to solve your latest business challenge, Sarah and I want you to ask yourself a few questions first. You might find you already have the solution you need!) This one is jam-packed full of advice. Don't miss out - listen now!Sarah's Bio:Sarah Greener is passionate about businesses - mostly small ones. For the past 7 years, Sarah has been helping busy, stressed and overworked business owners transform their business and reignite the passion they had when they started out.Growing up in a family that ran on business and a keen entrepreneurial spirit, gave Sarah a thorough grounding in the fundamentals. From there, she went on to own and run multiple businesses, in New Zealand and overseas. These ranged from retail through to e-commerce businesses, where she ran small to medium teams and dealt with the day to day operation. Each new business threw up different challenges as she thrived on the constant and never-ending improvement of each business.Despite her natural business drive and knowledge, Sarah still made plenty of mistakes. But here's the thing, there's no learning or growth without mistakes. Eventually, she got caught up in the same game most business owners get into - where the passion they once felt for their business becomes all emotion and busy noise. She knows what it feels like to become overwhelmed by the ineffective activity of working in your business rather than on it, and she has helped many business owners exit that cycle.Sarah enjoys providing actionable insights to audiences of all sizes to help them put into action immediate ways to strike that necessary balance and stop the overwhelm.Resources and links mentioned:Sarah's siteSarah's LinkedInSarah's FaceBookSarah's InstagramSarah's YouTubeSarah's resources just for PKTA Listeners!The Life-Changing Magic of Tidying Up by Marie KondoCome kick ass with me:Permission to Kick Ass websiteAngie's Facebook PageAngie on InstaAngie on YouTubeDownload this episode

This is THE fragrance episode you've been waiting for. If you're ready to talk top notes vs. base notes, Eau de Toilette vs. Eau de Parfum, get ready for this fascinating discussion with Asia Grant, the co-founder of fragrance brand Redoux. We dive into her relationship with fragrance growing up, why gendering fragrance is a waste of everyone's time, the story behind her new bar soap products, launching a Black-owned brand during the pandemic, and more. Links to Products/Resources Mentioned: Redoux, Mountain Rose Herbs, Tom Ford (Black Orchid, Tuscan Leather, Neroli Portofino, Soleil Blanc), Byredo (Gypsy Water, Bal d'Afrique, Eleventh Hour, 1996), Frederic Malle (Portrait of a Lady, Baccarat Rouge 540), D.S. & Durga Join the Naked Beauty Community on IG: @nakedbeautyplanet Check out nakedbeautypodcast.com Follow Asia: @asia_grant Hosted on Acast. See acast.com/privacy for more information.

Eau de Campagne by Sisley (1976) + Robert Wise's The Sound of Music (1965) with Ava Pearlman To hear this episode and the complete continuing story of The Perfume Nationalist please subscribe on Patreon.  1/5/22 S5E16