Podcasts about Mennonites

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Dr. Deb Muth 00:00:09 Hi there, how are you? Bob Miller 00:00:10 Excellent! Pedaling as fast as humanly possible, but doing okay. Dr. Deb Muth 00:00:14 Good, good. Well, I’m looking forward to our conversation today. This should be amazing. Bob Miller 00:00:20 Yeah, it should be a lot of fun. Dr. Deb Muth 00:00:22 Yeah, anything that’s off-limits for you in, our conversation? Bob Miller 00:00:28 No. Dr. Deb Muth 00:00:29 Okay, anything you want me to make sure we cover for you? Bob Miller 00:00:33 Well, I mean, is it okay if we put a little plug-in for our software? Dr. Deb Muth 00:00:35 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:38 Hey, can we… can we do a screen share? Yes, we can. Yeah, because I want to show you some maps, and… Dr. Deb Muth 00:00:43 Okay. Things like that, yeah, so… Perfect. So just let me know when you want to do screen share. Bob Miller 00:00:48 Okay. Dr. Deb Muth 00:00:49 And yeah, feel free to plug your software wherever you want to. Bob Miller 00:00:53 Okay, well, good. Let me pull up a, a slide for that, and give me one second, I just want to shut the door to my office to get the noise down. Dr. Deb Muth 00:01:01 No worries. Bob Miller 00:01:16 And, how should I refer to you? Dr. Debb? Dr. Muth, what do you like? Dr. Deb Muth 00:01:18 Dr. Deb is great, or Deb, either way, I’m pretty informal, so… Bob Miller 00:01:22 Yeah, and… Bob is fine for me. Okay. Yeah. Yeah, there you go. Why people feel like they need this, son. Special name, it’s like, seriously. Dr. Deb Muth 00:01:33 Right? I agree. Bob Miller 00:01:35 When I work with my clients, it’s like, Dr. Millison, just, just bop, just, just bop. Dr. Deb Muth 00:01:41 Yep, that’s how I am, too. Just call me Deb, it’s good. Dr. Deb Muth 00:01:44 They feel a little awkward with that, you know? They’re not used to that, but… Bob Miller 00:01:48 Alright. And you’re a naturopath, medical doctor. Dr. Deb Muth 00:01:52 A nastropathic doctor and a nurse practitioner. Oh, nice. Yeah, so I got the best of both worlds, right? Bob Miller 00:01:58 Yeah, damn. Okay. Alright, so here we go… There we go. Alright, so I got that ready, and then I will do a, I will do a screen share. I think you’re gonna really, appreciate what we’ve come up with. We’ve come up with the concept of, Cellular CPR. Dr. Deb Muth 00:02:23 Oh, nice! Bob Miller 00:02:24 And that is, construct the cell membrane, Protect the cell membrane. And restore it if it’s damaged. Dr. Deb Muth 00:02:32 Love that. Bob Miller 00:02:34 I love that. Yeah, so that’s what we’re focusing on, and then how, You know, we want to get to the point that, you know, most people think of genetics, they think of, like, 23andMe or Ancestry. Dr. Deb Muth 00:02:44 Yeah. Bob Miller 00:02:45 And then you have the professional geneticists who are looking at, you know, odd things that could create a disease. We’re looking at functional genomics. Dr. Deb Muth 00:02:54 Which is so much better. Bob Miller 00:02:56 Yeah. Are you familiar with what we do here, or… Dr. Deb Muth 00:02:58 A little bit, a little bit. So, it’ll be new to me, too, so I’m excited. Bob Miller 00:03:03 And how much time do we have? Dr. Deb Muth 00:03:04 We have an hour, give or take a little bit on either side. Do you have a hard stop anywhere? Bob Miller 00:03:10 No, no, I put a, I moved my clients around, and I don’t have anybody till, 3.30, so we’re good. Okay. Dr. Deb Muth 00:03:16 Perfect. Alright. Bob Miller 00:03:18 It’s like we’re getting started early as well, so… Dr. Deb Muth 00:03:19 Yeah, we’re getting started a little bit early, so that’s good. Bob Miller 00:03:22 Yeah, I just got my office cleaned up, so… Dr. Deb Muth 00:03:23 Okay, good. All right, are you all set to get started? Bob Miller 00:03:28 I’m good to go, my friend. Dr. Deb Muth 00:03:29 I’m gonna just record a little intro and a little bit of a, hook for people, and then we’ll get started. I’ll ask you to kind of tell us a little bit about yourself, and then we’ll just take this conversation wherever it’s supposed to go. Bob Miller 00:03:39 Okay, you got it. Dr. Deb Muth 00:03:40 Alright, sounds good. So what if the reason you’re not healing isn’t your diet, your supplements, or your labs, but it’s actually your genes? Dr. Bob Miller is uncovering how genetic variants, when combined with modern toxins, explain why some of us stay sick no matter what we try. Today, we’re talking genetic pathways, detox blocks, and the new science every wellness warrior needs to know. Welcome back to Let’s Talk Wellness Now, the show where we uncover the root causes of chronic illness, exploring cutting-edge regenerative medicine, and empower you to heal from the inside out. I’m Dr. Deb, your medical detective, and today, our guest, Dr. Bob Miller, is a true pioneer in functional genomics. He’s a board-certified traditional naturopath and the founder of Neutrogenetic Research Institute. And he’s the leading groundbreaking research on how genetic variants influence chronic illness, inflammation, and detoxification. His work has been recognized on international stages, uncovering links between genetic expression and conditions like Lyme disease, mast cell activation, or MCAS, and mitochondrial dysfunction. I’m so excited to talk to Dr. Bob today. He is gonna reveal some things that even I don’t know about, so I’m excited to learn alongside of you guys. So… Dr. Bob, let’s get started. Tell us a little bit about yourself, and kind of how you got on this journey. Bob Miller 00:05:04 Well, that’s, that’s interesting. I was sort of like a mid-career coming to the natural health field, because in my early 30s, I found myself with a severe case of ulcerative colitis. Bob Miller 00:05:15 And I was in the hospital for 21 days. probably within hours of death, pleading to death. And they told me I’ve got one option, and that is cut out the colon and wear a bag. Didn’t sound like a lot of fun. Dr. Deb Muth 00:05:27 Not an option I would want. Bob Miller 00:05:29 So, you know, the medical folks wasn’t real happy with me, but I said, yeah, I’d like to explore some alternative things.Never thinking that I’d get into this field, and then I just, you know, worked with some herbalists and things that I found absolutely fascinating. So, that’s how I got into this around 30 years ago. And, haven’t looked back since, and just having a… having a blast as we now move into how our genetics impacts things. So, that’s what we’re gonna… that’s what we’re gonna talk about today. Dr. Deb Muth 00:05:58 I’m excited to talk about this genetic thing. When you started over 30 years ago, what kind of patience and problems first inspired you to dig deeper into that root cause healing and kind of get into the genetic piece of it? Bob Miller 00:06:10 Sure. Well, you know, as a… now, I’m in a part of the country called Lancaster County, Pennsylvania, where there’s a lot of Amish and Mennonite, and they gravitate towards these things.So, this is their first thing to do, and that doesn’t work, then they’ll go other routes. So, you know, back then, we just saw typical, you know, a little tired, constipation. You know, a little bit of fatigue, arthritis, those kind of things. But things have changed dramatically over the years, as people are now getting more chronically sick. You know, it’s worse than it’s ever been. And what we’re finding is the, the culprits Primarily is mold exposure and Lyme disease. When people get those two together, they’re just… it’s an inflammatory cascade that nobody can seem to unravel. So that’s where we spend a lot of our time. And we’re also spending a lot of time looking at mental health, like ADD, ADHD. And, we give… this year I’ll be speaking at three autism conferences. And we can dig into that a little bit as to why we think we’re seeing such a dramatic increase. And aside from autism, that used to be 1 out of 1,000, now it’s 1 out of 33, or 23. You know, we’re also seeing dramatic increases in ADD, ADHD. People are stressed out. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. Dr. Deb Muth 00:07:37 This should be a fun visit. We can cover lots of topics. I am so excited. So, you founded Nutri Genetic Research Institute in 2015. What did you hope to accomplish, and what kind of surprised you in your findings so far about that? Bob Miller 00:07:51 Well, you know, let’s back up at what, you know, genetics is used for. Everybody’s familiar with 23andMe and Ancestry that, you know, tells you where your ancestors came from. Then you have your professional geneticists. I mean, these are people with a degree in genetics. And they’ll look for, you know, very odd sort of things that are prone to relate to a disease. So there are disease-related genetics. Well, in functional, we don’t look at either of those. We look at For example, how you’re breaking down your fats and utilizing them. How you’re recycling your glutathione. How you might be handling your iron. And none of those are disease-causing on their own.And none of those are disease-causing on their own. But when they pile up on you, and then combine that with environmental factors, that’s when things start to go south on us. So, that’s what we’re doing, we’re looking at patterns. And our first foray into this was, we did studies on Lyme disease. And our first foray into this was, we did studies on Lyme disease. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. Others have a little more struggle, and then others are struggling terribly for years. So there’s an old adage of genetics loads the gun, environment pulls the trigger. Dr. Deb Muth 00:09:14 Yeah, that is so true, and I think when we’re talking about Lyme and mold and things like that, we forget sometimes that our genetics can predispose us to be more sensitive to those things, and if we have genetic pathways where we don’t clear things properly, it’s harder for us to get them out of the body. And then you add on that whole rain barrel effect that we’ve always used as a functional medicine term, right? If the barrel’s half full, you’re okay. If it’s full, and now it’s spilling over, it’s a bigger problem. Have you guys found, too, that some of these environmental things actually are changing the genetics of people, or how they’re processing their own genetics? Bob Miller 00:09:53 Well, let’s go back to, Genetics 101. But we’ll go back a little bit further. So, what an interesting mechanism, what a miracle the body is. Bob Miller 00:10:03 Fats, carbohydrates, proteins, drink water, breathe air, expose the sunlight, and somehow everything gets made. I mean, when you just step back and think about that, it’s like, It’s pretty darn amazing. Dr. Deb Muth 00:10:15 I always tell women, you know, the fact that we get pregnant and we have healthy pregnancies and births is a miracle, because if we had to try to control that, that wouldn’t work so well. Bob Miller 00:10:25 Right. Well, that’s another miracle. These microscopic sperm and egg, human being, 9 months later, it’s like. But even inside of us. We are making our hair, our skin, our nails, our blood vessels, our ATP, our energy, it’s all being created. Well, that gets created by enzymes. So, enzymes take one substance, combine it with something else, and make something new. Then another enzyme comes along and does the same thing. Your DNA is the instructions on how to make the enzymes. So, when we are conceived. If it’s a, if it’s a female, of course, it’s the XX, the two chromosomes. You know, we’ve… everybody’s seen those… the genetics that… Listed pair. So, if it’s a female, the father donated the X enzyme. And the mother has no choice but to give the eggs, so that’s female. If the father donates the Y, you have a male that’s in chromosome number 1. Then 2 through 23 is the rest of the instructions on how to make enzymes. So, what can happen? We can get what are called SNPs, single nucleotide polymorphisms. And SNPs just mean that the instructions to make the enzyme’s not quite as good. So, if one parent gives a SNP on the making of an enzyme, The enzyme’s fine. It works. But, general rule of thumb, It may only work at 70-80% of efficiency. Now, a good analogy is think of an 8-cylinder and a 6-cylinder car. If parents give you good information, that’s like having an 8-cylinder car. If one parent gives you that snip, it’s like having a 6-cylinder car. Now, is a 6-cylinder car a fine car? Sure. It’ll get you from point A to point B, but it’s just going to have the power of an 8-cylinder. Then if both parents give you a SNP on the same enzyme, it may be 30-40%, and that’s like having a 4-cylinder car. Sits in the driveway, looks the same, puts gas in it, everything. But if you’ve got a 4-cylinder car. Probably not a good idea to go cross-country pulling a trailer behind you up and down mountains. Dr. Deb Muth 00:12:29 This is true. Bob Miller 00:12:32 So… We can get an 8-cylinder, 6-cylinder, or 4-cylinder enzyme. Now, if it’s not under a lot of stress, if that 4-cylinder car is just taking you to the bank and the grocery store. It’s just as good as an 8-cylinder car. But if you gotta pull that trailer, and there’s a lot of stress on it, being mountains, it’s gonna struggle. Now, there’s one other little caveat to this, and that is some genetic mutations are gain-of-function. They actually work faster. Now, we have enzymes that do all kinds of things. We have enzymes that make and recycle our antioxidants, but we also have enzymes that make inflammation. No, that’s a good thing, because if we get a virus or bacteria, if you didn’t make inflammation to kill it, well, we’d all die of infection. So, you know, we tend to think of free radicals as bad, antioxidants as good. They both play an important role. But interestingly, some of the major enzymes that make inflammation, they can be overactive. They can be turbocharged. And when they’re stimulated by environmental toxins, they overreact. Bob Miller 00:13:40 And therein lies the problem. When they overreact, we have a problem. Bob Miller 00:13:46 So, if we have genes that overreact when stimulated. And then the enzymes that take care of inflammation are underactive. Then you’re gonna be more inflamed. You know, the majority of people that, you know, come for functional medicine Or naturopathic help, or… Inflammation that they can’t seem to get under control. Dr. Deb Muth 00:14:06 Right. Bob Miller 00:14:07 And we will be, you know, during this hour, we’re going to look at some of the pathways that make that happen. So, what we can do then, we can’t change our genetics. When you’re conceived, that’s the hand you’re dealt. When your life would be over, if someone would take some tissue and measure, it’d be exactly the same as conception. Does it change. Bob Miller 00:14:28 The enzyme’s ability to do its job may be compromised. Because remember I said there’s a, the enzyme takes a cofactor. So an enzyme takes substance A, cofactor, make substance B. Well, if that cofactor’s not there, the enzyme’s not going to work either. So, you could have an 8-cylinder car, and if there’s no gas in it, it’s not going anywhere. So… It’s the strength of the enzyme, it’s the cofactor to do the A to B conversion. And that’s what we’re going to get into. So, many people say, well, where did these SNPs come from? Nobody knows for sure. Sometimes they’re what’s just called de novo, when the sperm and egg go together, the instructions get mixed up a little bit. We do believe a lot of it came from a long time ago, when we were almost wiped out by sexually transmitted diseases. And those STDs were altering the genes when the conception, in other words, when the sperm went into the egg, the STDs were interfering. And causing the problem, so… I often joke, if you want to blame somebody. Blame your great-great-great-great-great-great-great-grandparents for, being a bit promiscuous, so… Dr. Deb Muth 00:15:31 Yeah, for being… having a little too much fun, right? Bob Miller 00:15:35 So, we don’t know for sure, but, you know, there are some that, But most of the SNPs that we get inherit from our parents. So, if you look at a child. And you look at the SNPs. 99.9% of the time, it came from one of the parents. Dr. Deb Muth 00:15:50 In identical twins, do they have the exact same identical makeup? Bob Miller 00:15:54 Yep, Dr. Deb Muth 00:15:56 But not in fraternal twins, correct? Bob Miller 00:15:59 No, no, those could be different, Jeff. Dr. Deb Muth 00:16:00 It could be different because they have different sacs, they’re not sharing that same genetic makeup. Bob Miller 00:16:04 Yeah, so keep in mind, both your mother and your father have, you know, the two And so you get one from one parent, one from another. Dr. Deb Muth 00:16:13 So… Bob Miller 00:16:14 Interesting situation. I had, 3, 3 boys. And, we were looking at an enzyme related to breaking down oxalates. Now, the mother and father each had one SNP, and that’s called heterozygous. Three boys, and they all come together, they’re Amish boys, they’re a lot of fun. And I looked at their genomes, and the one boy didn’t have any SNPs at all. And one had won. And the other one had two. Dr. Deb Muth 00:16:41 Interesting. Bob Miller 00:16:42 So, we don’t quite know how these things get handed off, but with the parents each having one, you could have a child with none, one, or two. So, the one, his ability to break down oxalates, which is fine. The other one was slightly impaired, and the other one was dramatically impaired. So, you can have 3 children, and it all depends what the parents have. Now, if a parent has a homozygous, or 2 copies. And the other parent has nothing. Every child will have one. Okay. If both parents are homozygous, that they both have two, Every child will have two. Dr. Deb Muth 00:17:19 too. Bob Miller 00:17:20 Yes, so that’s the way it works, but, you know, but it’s somewhat rare that both parents are homozygous on an enzyme, but it can happen. Dr. Deb Muth 00:17:27 Do we think that infections today, like Lyme disease or mold exposure, things like that, if the parent, the woman, primarily, I’m thinking, is pregnant, and she actively has these infections. Can those infections affect the genetics, kind of like a past sexual transmission did where we thought back in the day? Bob Miller 00:17:47 Yeah, I… I mean, I’m not that much of a geneticist to answer that for sure, but my thought would be no, that at conception, the pattern’s made. Dr. Deb Muth 00:17:55 Okay. And then that’s… that’s the hand you’re dealt. Bob Miller 00:17:58 Yeah. So, I tell people we have good news and bad news. The good news is we can compensate for the weakness. The bad news is we can compensate for the weakness. Dr. Deb Muth 00:18:09 That is so very true. Bob Miller 00:18:11 Yeah, we can’t, because I often get asked, so we’ll do some things now, and we’ll check my genes again, and they’ll be better. It’s like, nope. Dr. Deb Muth 00:18:18 Oh, – – Bob Miller 00:18:19 You gotta play the hands you’re dealt, so… Dr. Deb Muth 00:18:21 That’s right. Bob Miller 00:18:22 You can test your genetics… if you’re looking at the same enzyme, you can test it every year. It’s not gonna change. It’s like the blueprint. Dr. Deb Muth 00:18:30 It’s good and bad, right? It’s the one test you only have to do once in your lifetime. Bob Miller 00:18:34 No, unless, you know, like, our. Dr. Deb Muth 00:18:36 All the time. Bob Miller 00:18:37 Yeah, now our test looks at, called the Functional Genomic Analysis Test of your genomic Resource. We look at 220,000 steps. Dr. Deb Muth 00:18:46 Wow, that’s a lot. Bob Miller 00:18:47 That’s not all of them. Dr. Deb Muth 00:18:49 Right. Bob Miller 00:18:50 So, maybe in the next year, we’re gonna come out with our third version of the chip. And then, if someone wants to get those new things that weren’t on it, they’d have to repeat. But whatever we measured is gonna stay the same. Dr. Deb Muth 00:19:03 That’s a lot of SNPs to look at. Bob Miller 00:19:05 Keeps us busy. Dr. Deb Muth 00:19:06 But there’s still, but there’s still SNPs that we. Bob Miller 00:19:09 That we’d like to have that we don’t have, so… Bob Miller 00:19:11 We started out with version 1 on our genetic test, then we worked with version 2, and we’re already compiling a list of what version 3 would look like. So if somebody has our version 2, And we’re saying, you know what, it’d be nice if we could see these, well, then you’d repeat, but it won’t change what you already know, so… Dr. Deb Muth 00:19:29 Got it, got it. So, when you started out, and you started looking at the research of Lyme disease and chronic infections, which detox pathways are most important for people who struggle with those conditions? Bob Miller 00:19:43 Okay. You know what might make sense as we do a screen share, and I’ll actually show you the pathway. Does that make sense? Bob Miller 00:19:48 Alright, so… let’s see if I… let me just press the share… Dr. Deb Muth 00:19:52 Yep, you should just be able to press share. Bob Miller 00:19:54 And… number 2. Okay. Are we seeing the screen there? Bob Miller 00:20:01 Okay. Dr. Deb Muth 00:20:02 So, this is a map that we made. Bob Miller 00:20:05 And by the way, this is not… All-inclusive of all the things we look at, but we believe this is a core issue. So, where we’re going to start here, there’s something called the microglia. And the microglia are glial cells. They’re in the brain and the central nervous system. And they’re very interesting little creatures, because most of the time, and this is just a drawing of what they sort of look like. Most of the time, they’re in what’s called the M2 anti-inflammatory mood. What that means, these little guys pick up dirt, debris, Recycle them. Turns on an enzyme called interleukin-10 that’s anti-inflammatory. And just kind of does general housekeeping. And just kind of does general housekeeping. However, when a trigger comes along. However, when a trigger comes along. They… it’s the same glial cell, but it moves over to a very pro-inflammatory enzyme. A pro-inflammatory glial cell. And it triggers these 3 enzymes, Actually, these four. That are pro-inflammatory. Tumor necrosis vector alpha, Interleukin-6. NF Kappa B, Inos. Now, these create inflammation. So you might think, well, why is that good? Well, if you have some foreign invader, virus, bacteria coming in, parasite. If you didn’t have these guys coming to the rescue, you would just die of infection. So, these guys are your friend unless they’re your worst enemy. Because TNFA, and we’ll show you when we actually do a demo account, TNFA can be overactive. So, in other words, it over-responds. Interleukin-6 can be overactive. And if Kappa-B can be overactive. The INOS, and I’ll explain each of these as we go through a demo, can be overactive. Now, what that means is, you’re very good at killing virus and bacteria. But this is where autoimmune disease comes in, and just inflammatory conditions. Now, this is just speculation, but we think what happened is, as you know. Thousands of years ago, we didn’t have refrigeration, we didn’t have sewer, we didn’t have pure water, and we didn’t have antibiotics. So, if you made it to 40, you were an old-timer, because everybody was dying of infection. So, what we believe happened is, by what’s called natural selection, Having these overactive. A thousand years ago was to your advantage. Dr. Deb Muth 00:22:31 Hmm. Bob Miller 00:22:32 But now… We have pure water, we have refrigeration, we have sewers, we have antibiotics. But now we have environmental factors that are stimulating them. Now it’s to our disadvantage. And we’ll talk about that a little bit as it relates to the hemochromatosis genes and maybe the G6PD. Dr. Deb Muth 00:22:48 Yep. Bob Miller 00:22:49 Now, why are we becoming so inflamed? Let’s look at the triggers. Now, one of my, favorite expressions is. I was born all the way back in 1954. Dr. Deb Muth 00:23:01 And it was a different world back then. Bob Miller 00:23:05 These are some of the triggers. And we’ll get into these, but right now, high fructose corn syrup, And the high-fat diet. High fructose corn syrup only came about in 1968. So now we’re being exposed to high fructose corn syrup. Then… we didn’t have these, these viruses like COVID. Dr. Deb Muth 00:23:26 Yeah. Bob Miller 00:23:27 Now, there’s now pretty strong evidence that COVID Was actually, you know, made as a gain of function. It’s debated, and I’m not taking an opinion on it, but there’s some people who believe Lyme disease was also a part of experimentation. Dr. Deb Muth 00:23:40 Go. Bob Miller 00:23:41 Then we have molds, and it appears as though mold is getting stronger. you know, 20 years ago, when I was seeing folks, mold wasn’t on the radar. I would say 7 out of the 10 folks we speak to today have mold problems. Yeah, 20 years ago, we talked more about mold allergy being an issue versus mold toxicity being an issue. Right. So… I know some folks are, you know, speculating what’s happening, but one of the theories out there is that EMF is strengthening mold. I don’t know if you ever heard that theory, and I don’t… Dr. Deb Muth 00:24:13 I have. Bob Miller 00:24:14 I’m not claiming it’s true, but it’s an interesting theory. Then even, you know, your black mold from water-damaged buildings. Then our air pollution is getting worse. We’re getting more toxic metals. Dr. Deb Muth 00:24:26 You know, if we have a… Bob Miller 00:24:27 You know, we’re gonna look back someday and say, what were we thinking, smearing aluminum into our armpits? The, what were we doing putting mercury in our teeth? Then, you know, glyphosate. When I was a kid, there was no glyphosate. So, all of these herbicides and pesticides. Polychlorinated biphenols, And then EMF. So, we love our cell phones, you know, and I think unless you, or in the middle of the desert, or down in a cave, you’re being exposed to EMF somewhere. So, you know, we have our cell phones with us, we have, We have Wi-Fi, the towers are everywhere. And we don’t know long-term, but we may find that this can… this creates some inflammation. And I don’t know if you get any folks, but do you have any folks that have… are they EMF sensitive? Dr. Deb Muth 00:25:16 Oh yeah, we have a whole bunch of them. Bob Miller 00:25:18 Yeah, and then if you have any TBIs, So, plenty of things here. that will stimulate into the microglia, M1. Now, you could say, well. We’re all pretty much exposed to the same thing. Why do some people get hit harder than others? So here’s where we’re gonna start. There’s an enzyme called Nrf2 and RF2. And Nrf2 is the enzyme that senses when there’s inflammation. And turns on hundreds of anti-inflammatory enzymes. We’ll show when we do the demo, you can have genetic weakness on NERF2. And NERF2 inhibits and slows down microglia M1. supports M2. Now, if it’s not complicated enough, there’s an enzyme called KEEP1. And KEEP1 inhibits NRF2. And you can actually have gain of function on keep 1, that makes Keap 1 stronger. So… A lot of the people who land on my doorstep So… A lot of the people who land on my doorstep Both parents gave a mutation on KEEP1, making it overactive. Both parents gave a mutation on KEEP1, making it overactive. Dr. Deb Muth 00:26:31 Hmm. Dr. Deb Muth 00:26:31 Hmm. Bob Miller 00:26:32 Suppressing Nrf2, nerve 2 might be weak. So, nobody’s putting the brakes on, M1. And by the same token, Nerve 2 supports M2. Then there’s a process called mTOR and autophagy. mTOR stands for mammalian tard of rapamycin, the growth of new cells. And then autophagy, taking our dead cells and recycling them. We need a balance between the two of them. If we didn’t have mTOR, the sperm and the egg would never become the baby, the baby would never become the adult, we wouldn’t make new cells. But our cells are constantly, you know, the old cells dying off. Autophagy is where we take that debris from the cell and recycle it, just like a farmer Plows the crop under at the end of the year. The dead plant then becomes the fuel for the spring, your dead cell becomes the fuel for the spring, and that’s autophagy. So we’re gonna look back someday and say, what were we thinking? We give our animals growth hormones so they get fatter faster. Oh my. So, we consume those animals, and inventory runs faster. Now, for anybody who’s, You know, maybe above 40, 45 years old. Think back when you were 12, and what did girls look like? They were primarily flat-chested little girls. Now they look like 16-year-olds. Because environmentally, we’re jacking up mTOR. So, mTOR stimulates microglia M1, suppresses microglia M2. Probably 80% of the folks we visit with. This is the part of the problem. NRF2 is weak. mTOR is strong. Environmental factors come along. And this guy gets carried away. He doesn’t do that burst and move back. Stays here. We’re calling that How environmental factors create a locked-in, pro-inflammatory. and neurotoxic phenotype. In other words, once it starts, it just keeps… Feeding upon itself. Alright, so what happens now when microglia is overactive. it triggers these 3 enzymes, TNFA, N of kappa B, And interleukin-6. Each one of these can have genetics that make them run stronger. Then it stimulates an enzyme called NLRP3, Which makes what are called inflammasomes. Now, guess what inflammasomes can be? Your best friend or your worst enemy? Because they will, if you’ve got, again, a virus or bacteria, or possibly even some bad cells in the body. They will zap them. Well, that’s good. Unless it’s overactive. Unless it’s overactive. And then what it does, through interleukin-1 beta, makes excess glutamate. And then what it does, through interleukin-1 beta, makes excess glutamate. Anxiety, gut inflammation, OCD, ADD, autism. And, you know, glutamate, we’ll talk about that a little bit, but glutamate makes you intelligent, highly motivated go-getter. but can also be excitatory. And then, look what it does. Let’s see, do I have the drawing tool here? Yes, I do. Okay. So, it comes down through here, Makes the glutamate. Comes back up through here. through the ADORA 2A enzyme, Then we’ve got a feedback loop that feeds upon itself. Then, through interleukin-18, we make histamine. and mast cells. And then through histamine receptor site number 1, we come back and spin it. And now you’ve just got this spinning feedback loop. So, the glutamate will make you anxious, the histamine will give you allergies and make you anxious. And you’re allergic to everything, and you’re feeling horrible. Now, it doesn’t end there, Dr. Dad. It then goes on to make something called gast dermins that creates pyroptosis, where it actually starts punching a hole in the cell membrane. And you’re only going to be as healthy as your cells are. Just a little background. You know, we’re made up of trillions of cells, and each one of them has what’s called a lipid bilayer, made from lipids, which comes from fats. And you’re only going to be as healthy as those membranes are. So that’s why we coined an interesting phrase. Cellular CPR. Construct the cell. Protect the cell. And restore the cell membrane. And we believe that’s going to be revolutionary in the functional medicine world. So… It’s not hard to figure out that if you start punching holes in the cell membrane, that’s not a good thing, okay? Bob Miller 00:31:22 Now… There’s an interesting molecule called NAD. Thicotide adenoside dinucleotide. And anybody who’s in the, you know, listening to the health podcasts and things, they’re… They’re, they’re learning about NAD. And I’m going to show you a chart later, all the good things that NAD does, but For the most part, it helps what’s called sirtuins. And sirtuins are quite interesting. If anybody’s looking at longevity. The sirtuins is where they’re looking at.Because sirtuins turn on good things. Turn off bad things. And I’ll show some charts on that later. So for right here, this sirtuin uses NAD, to slow down NF-kappa-B. CERT 2 uses NAD to slow down an ORP3. So, if we’ve got genetic weakness on these, or we don’t have enough NAD, We don’t hold this pathway back. Make sense? Dr. Deb Muth 00:32:24 Yeah, makes perfect sense. Bob Miller 00:32:25 Now, I’ll show this a little bit later. So, people are like, oh, well, I’m gonna start taking some NAD. Dr. Deb Muth 00:32:31 Right. Bob Miller 00:32:32 And there’s functional doctors who give NAD intravenous. It was just this morning, I was talking to a woman who said, Oh my gosh. I went and got intravenous NAD, and it took me a month to recover from that. Dr. Deb Muth 00:32:45 Hmm. Bob Miller 00:32:46 what happens is, and I’ll show this in a little more detail, there’s an enzyme called CD38, that’s stimulated by NF-kappa-B. And it takes NAD, To make intracellular calcium. that stimulates NLRP3 and actually makes things worse. So, if we have this guy upregulated, and I’ll show a chart what does that. taking NAD will make you worse. Again, when I go into the software, I’ll show you that whole pathway, so… I would encourage people, you know, just don’t go out and start taking massive amounts of NAD, you know, stick your toe in the water, see how you do. Because everything you’ve heard about, how good it is, is true, unless this guy says, oh, thank you very much, let me make more inflammation. Now, this might be part of our innate immune system, that if we have some pathogen that’s gonna kill us. By golly, we want that to happen. But if this is happening by environmental factors, Then it’s detrimental. So the immune system that protected us a thousand years ago now might be turning on us because of the environmental factors that we showed earlier. All right. Then there’s an enzyme called PARP that’s NAD-dependent, and that actually repairs strain breaks in your DNA. Now, the next thing that happens… is there’s an enzyme called NADPH oxidase that gets stimulated. and something called INOS. Now, I’m sure most people know about nitric oxide. It’s a gas that dilates your blood vessels. That’s why sometimes they’ll even give people drugs, nitroglycerin, to boost their nitric oxide. That’s why people are doing beetroots and other things to boost their nitric oxide. But there’s an OS3 enzyme that makes the nitric oxide that’s good for blood flow. But there’s an INOS That makes nitric oxide to kill pathogens. probably might be the third or fourth time I’ve said this. That’s a good thing, unless it isn’t. So, if it’s killing some pathogen, great. It was just misfiring. it combines… With superoxide that’s made by this enzyme, and makes something called peroxynitrite, which is one nasty free radical that chews you up and spits you out. So, the NOx enzyme, NADPH oxidase, uses NADPH, To make this free radical called superoxide. If we have time, we’ll get into it. NADPH is what your body needs to recycle your antioxidants.So, I coined the phrase, the NADPH steel. Where the NOX enzyme takes this very important NADPH, And rather than being useful, makes superoxide. Now, again, is that fine if you’ve got some bacteria to kill? Of course. But if it’s just chronically running, it’s just making all this chronic inflammation. Then it makes something called hydrogen peroxide. And we need to clear hydrogen peroxide by 3 enzymes, catalase, thyroid reduction. And glutathione peroxidase. If we have genetic issues on here, or we don’t have the cofactors. There’s something called the Fenton reaction, discovered in 1895 by Dr. Fenton. Where hydrogen peroxide combines with iron to make what are called hydroxyl radicals. And guess what they do? They create lipid peroxides, That damages your cell membranes. Now, again, the body’s pretty darn amazing. We have glutathione, And here’s where your body’s taking glutathione and recycling it. But look who’s needed to recycle it. NADPH. So, if this guy up here is chewing it up, We don’t recycle our glutathione. And then an enzyme called glufon peroxidase 4, Takes this damaged lipid and repairs it. So, here we’ve got this protecting, we want to protect it by not having this happen. But then we also need this guy to do the restoration. So, there’s a lot that can go wrong in here, Dr. Deb. Dr. Deb Muth 00:37:07 There’s a lot that could go wrong. And I can imagine some of my listeners are thinking that lipid peroxidase, is that the same thing as what they’re thinking of when we talk about lipids and cholesterol? Is that the same process that’s happening there? Bob Miller 00:37:22 Well, no, no, the lipids can be used to make cholesterol, but here we’re talking about where they’re going to build the cell membrane. And they’re being… and they’re being, destroyed. If anybody would like to see a visual representation of this, just go on YouTube. And type in, ferrooptosis Animation. cool little video, it’s about 3 minutes long, and it shows the lipids coming over, being oxidized, and now GPX4 fixes them, so… YouTube, Pharaoptosis Animation, cute little video. It’s just that really… Shows vividly what we’re… what we’re talking about here. Now, this is… Dr. Deb Muth 00:37:59 And so this is very common, too. Like, a lot of people do hydrogen peroxide IVs. Dr. Deb Muth 00:38:04 And so, if somebody doesn’t know their genetics, they could have a problem with doing those, just like they could doing the NADHIVs, correct? Bob Miller 00:38:13 Sure, yeah, yeah, yeah. So, I’ve talked to so many, you know, of course, the hydrogen peroxide kills pathogens. I mean, that’s what it does. So… but I’ve spoken to so many people that said. I had one client that said they’ve never been the same after having one hydrogen peroxide infusion. Dr. Deb Muth 00:38:30 Interesting. Bob Miller 00:38:31 Yeah. So… it can be… I see why people use it, because it. Bob Miller 00:38:36 pathogens, But on the other hand. And now’s a good time to speak about… I don’t have it on here, but there’s a, there’s an enzyme called the HFE gene. And that is what causes you to absorb iron. And there’s mutations in it that cause something called hemochromatosis. Were you overabsorb iron? Now, true hemochromatosis is when both parents give you a mutation. But there’s now growing evidence even a heterozygous can cause a little bit more iron absorption, not to the human chromatosis point, but overabsorption. So, if you overabsorb iron, And you have too much hydrogen peroxide that’s not cleared, All kinds of inflammation. Now, what’s happened is sometimes this inflammation Will damage the red blood cells. And some well-meaning doctor says, oh, you need some iron. And they take iron and it makes it worse. So, can’t tell you how many people I’ve said, you’ve got the overabsorption of iron, and they say, well, that can’t be right, because I’m low in iron. Well, that could be because it’s being chewed up here. Dr. Deb Muth 00:39:40 Sure. GPX1 and TXN turn it into, to water. The, catalase turns it into water and oxygen. Dr. Deb Muth 00:39:58 Now, I see a lot of my clients who have mutations or SNPs on that GPX gene, on that glutathione gene. And they really struggle to clear a lot of their toxins. Bob Miller 00:40:12 Sure. Dr. Deb Muth 00:40:14 Yeah, absolutely. Well, GPX4. Bob Miller 00:40:18 is what, repairs, but you can see GPX1 Is what uses glutathione. To turn hydrogen peroxide. So, but it all depends upon having enough glutathione. Dr. Deb Muth 00:40:30 Yeah. Bob Miller 00:40:31 Well, guess who controls making a glutathione? Dr. Deb Muth 00:40:34 Nerf 2. Bob Miller 00:40:37 So, if you have a keep one weakness, or strength to two… I’m sorry, keep one is too strong. Nrf2 is too weak. You don’t make glutathione. So, when a lot of people do that, it’s like, well, I’m gonna take glutathione. Dr. Deb Muth 00:40:51 Right. Bob Miller 00:40:52 And some do great, and some do poorly. You know, because… and I’ll show this on one of the other charts. You can see here that the, The glutathione has to be recycled. And if we don’t recycle it, it actually turns into superoxide free radical. So… NADPH are the cofactors, For taking the oxidi… here’s oxidized glutathione, here’s reduced. So, this is a good glutathione. After it does its job, you can see it becomes oxidized.We need to recycle it. Well, if we have weakness on the enzyme that does that, or a weakness in Nrf2, or not enough NADPH. The oxidized glutathione never gets recycled. So, I’ve talked to a lot of people who said, oh, glutathione made me so sick, and say, well. Dr. Deb Muth 00:41:43 Yeah. Bob Miller 00:41:44 You need it, but you need to recycle it. Dr. Deb Muth 00:41:46 Can you speak for just a brief moment, too, about MTHFR? That is a very popular gene, it’s all over social media as the major gene, but can you speak to a little bit about that, and how that fits into this whole process of things? Because it is just such a small piece. Dr. Deb Muth 00:42:04 understanding genetics. Bob Miller 00:42:06 Yeah, to be honest, it drives me nuts. Dr. Deb Muth 00:42:08 Me too. Bob Miller 00:42:11 Alright, so… You know, there are people on social media I won’t say what I think, I’ll be kind. But… But the, And, you know, they might mean well. But they talk about, if you have MTHFR and COMT and PEMT, that’s… oh my goodness, that’s horrible, and we’ll fix that for you, and you’ll be fine. Bob Miller 00:42:36 it just irritates me to no end. And it really could get anybody who’s doing this legitimately in trouble. I mean, I’m afraid someday, you know, there might be some cracking down on this kind of nonsense. Now, to answer your question about MTHFR. Dr. Deb Muth 00:42:51 I mean, it really is, but I’ll tell you what, why don’t we hold that thought until I go to another map and I can actually… Okay. Bob Miller 00:42:56 But the real… the cliff notes is the MTHFR puts a methyl group on your folate, which is needed, but it has gotten way, way, way too much attention. And people learn they have MTHFR, and they start taking a multivitamin with methylfolate, then they take a B vitamin with methylfolate. Dr. Deb Muth 00:43:13 And they’re pushing it too hard. Bob Miller 00:43:15 Yeah. So I can’t tell you how many people I’ve helped by saying, stop it. Dr. Deb Muth 00:43:20 Yeah, take less of it. Bob Miller 00:43:21 Take less of it, yeah. So, yeah. Yeah, there’s a… If somebody, say, ranked the enzymes at their level of importance, MTHFR might be 40 or 50 on a scale of 100, you know. Keep one Nerf two. big deals. Dr. Deb Muth 00:43:40 deals. Bob Miller 00:43:41 NQO1 that I didn’t even talk about yet, NQO1, takes your, NA… your NAD goes into NADH, To make electrons for the electron transport chain. you need NQ01 to bring that back. If that’s not working, and I’ll show you on the NAD map how disastrous that can be. Now, the next piece is here, and I think You know, if you talk to any school teachers and say, if you’ve taught for more than 10 years, how are the kids today? Every one of them says, more ADD, ADHD, more autism. Just look at human beings, we’ve never been so agitated. You know, everybody, and it might be a social media thing, but people take a position on something, and if anybody doesn’t share that position, they view them as the enemy. Dr. Deb Muth 00:44:29 And it’s kind of scary what’s happening to us. Bob Miller 00:44:33 So, we can’t agree to disagree anymore. We see anybody who has a differing opinion as the enemy. And, you know, there was… there’s people that didn’t have Christmas dinners together, because they had political differences, like… Dr. Deb Muth 00:44:44 Excuse me. Bob Miller 00:44:45 can’t you put your political differences aside to have Christmas together, you know? Dr. Deb Muth 00:44:49 Right? Bob Miller 00:44:50 become that, you know, no matter what your position is, and I’m not saying anyone’s right or wrong, I’m just saying. You know, in the old days, they used to say that the Republicans and Democrats in Congress would argue policy and then go have dinner together. And now everybody’s all up in arms, angry. Dr. Deb Muth 00:45:05 Yeah. Bob Miller 00:45:06 So… There’s likely multiple reasons for that. But let me show you one of them. That, you know, to what degree this is… very important, we don’t know, but I think We’re beginning to believe this is very important. So, there’s something… there’s a neurotransmitter called GABA. And God buys the don’t worry, relax, be happy. Chill. Okay. Dr. Deb Muth 00:45:31 Nobody has enough of that anymore. Bob Miller 00:45:33 Well, yeah, you’ll be surprised what I’m gonna show you. So, let me see if I can find a, Let me see if I can find the right slide here. Let me look for it here. So, there’s something called a GABA receptor site. And here you can see… This is a neuron, and this is where you, The neuron normally is excitatory. However, there’s normally low chloride in the neuron. Dr. Deb Muth 00:46:09 Hmm. Bob Miller 00:46:10 So, GABA itself is neither relaxing. For excitatory, all GABA does, it opens up what’s called a chloride channel. And then chloride, which has a negative charge, will flow into the neuron. Follow me there? Dr. Deb Muth 00:46:26 Yep. Bob Miller 00:46:27 And as it does, it changes this from a positive charge to a negative charge, And it’s relaxing. and inhibitory. Dr. Deb Muth 00:46:34 Hmm. Bob Miller 00:46:36 Now, on the other hand, there’s enzymes called NKCC1, That will push chloride in. and KCC2 that will bring chlor… oops and bring chloride out. And then there’s a sodium channel. And, sodium has a positive charge. And glutamate will push that in. So, as long as this is happening. And GABA says, receptor sites, open, chloride goes in, Chill. However, If NKCC1 Pushes extra chloride in. KCC2 doesn’t pull it out. and GABA hits the receptor site, the GABA comes flowing out, Sodium comes in, And now it’s excitatory. So Gabba didn’t change. GABA just opened the receptor site, that’s all it does. Dr. Deb Muth 00:47:33 Yeah. Bob Miller 00:47:34 But it’s the chloride balance that’s going to determine whether this is relaxing or not. Now, these are the things that go along with when they lose that KCC2 or gain NKCC1. Pain and sensitivity, burning electrical, neuropathic pain. Normal touch hurts. Sound and light sensitivity. Tinnitus can flare. Headaches and migraines. Seizure tendency. Body jolts. Spasticity, cramps, stiffness, startle reflex. Trouble falling asleep, non-restorative sleep. Anxiety, stress, reactivity, that’s what we have now. Hyperarousal, panic-like surges, irritability, racing thoughts. Brain fog, slowed processing, working memory slip-ups. Mental fatigue. Episodes of racing hearts, sweaty palms, guts on edge. Those are all the things that happen when this GABA switch occurs. Now, here’s what happens, and this is what I’m going to be presenting at an autism conference. When you have a newborn, they need that NKCC dominant to develop. By early childhood, it should… or, sorry, early adulthood. we should move over to the KCC dominant, that’s the taking the chloride out. Nice-looking 25-year-old boys, functioning very well. However, when we get microglia M1 upregulated. Because of environmental toxins, processed foods, Tylenol, aluminum. they stay in NKCC1 dominant, and there’s ADD, ADHD, Autism, the whole spectrum. because… They’ve not moved over to the… They’ve not moved over to the KCC2. And again, this is caused by… Environmental factors. Stimulating the microglia. And then, interleukin-1, interleukin-18 weakens KCC2, interleukin-1 beta, Strengthens NKCC1. high chloride. We open up the chloride channel, In Rebell Excitatory. So, I think when, When the pediatricians get ahold of this, they’re going to be very excited to know that This could be why we’re seeing such a rise, and not just autism, but ADD, ADHD, anxiety, the whole shit mess. Dr. Deb Muth 00:49:58 thing. Bob Miller 00:49:59 Yeah, so… and you can see NF-kappa-B stimulates that. These stimulate it, and I think that’s why everyone’s getting so anxious. Now, there’s a little bit more to it, and we’ll get into this when we look at some of the maps, but… The, the glutamate, Which is excitatory. will stimulate the NMDA receptor, make more glutamate, And glutamate will inhibit KCC2. And then we also need an astrocyte To, take both ammonia And glutamate, and… Turn them back into glutamine. And I’m going to talk to you a little bit about arachidenic acid, and if we have too much arachidenic acid. or TNFA is upregulated, that doesn’t happen. Ammonia goes up, and there may be multiple reasons for this, but this is a reason why some of the autistic kids do flapping. Dr. Deb Muth 00:50:49 Hmm. Bob Miller 00:50:50 Because they’re not clearing their ammonia. And you can tell if somebody has high ammonia by… they get that old person smell, you know. Dr. Deb Muth 00:51:00 Yup. Bob Miller 00:51:01 your vehicle cycle’s not taking out the, the ammonia. Now, last pathway here. There’s growing interest in mast cell activation. So, back here, we talked about peroxynitride. And that will stimulate mast cells, and those are white blood cells that are your best friend, unless they’re your worst enemy. Then it’ll make histamine. And there’s enzymes called histidine decarboxylase that’ll make more. Dr. Deb Muth 00:51:28 I’m sure everybody’s heard of DAO, the enzyme that degrades histamine. Yep. Bob Miller 00:51:31 We can have genetic weakness, we don’t make that. There’s an enzyme called histamine and methyltransferase, That, That breaks down the histamine. Then if we don’t do that, it’ll get stuck in the histamine receptor site. And then it’ll make something called, renin. Which will cause angiotensinogen to turn into angiotensin. One, that turns into angiotensin II,And that’s where people make aldosterone, where they’ll get the, The swollen ankles and high blood pressure. But interestingly, there’s an enzyme called ACE2, that takes this guy and turns it into angiotensin 1-7, Which is anti-inflammatory and also inhibits… TNFA. Now, you can have weakness on ACE2, But… and anybody’s saying, that sounds familiar? Dr. Deb Muth 00:52:25 That’s where COVID comes in, using ACE2. Bob Miller 00:52:28 And now we just found there’s literature that if you get COVID long enough, it can actually make ACE2 not be able to work as well. So look what it does. It comes down here, stimulates the NADPH oxidase, More superoxide. More peroxynitrite. And we’re on a cycle here. We’ve actually named this the Home Cycle Hypothesis, the proposed feed-forward loop. That just keeps feeding on itself. All being caused by… Primarily, The environmental factors. But hitting those who have genetic weakness the hardest. That’s why. Dr. Deb Muth 00:53:08 To the people. Bob Miller 00:53:09 Don’t live in a moldy house. One person is sick as can be, and the other person says, well, you must be imagining things, because I don’t feel anything. Dr. Deb Muth Yeah. Same thing with long haul, right? Two people can both get sick, one gets sick and never seems to recover, and somebody else gets sick, and they have absolutely no problems with it at all. Bob Miller 00:53:30 Sure. Well, think about it, if you get COVID, and ACE2 is weak, and some of this other stuff is going on. This thing just starts feeding upon itself. Dr. Deb Muth 00:53:38 Keep creating more inflammation, more complications, nothing’s calming down. Bob Miller 00:53:43 Yeah. Now, you, you ask about, MTHFR. So, this is the, this is the, the software called Functional Genomic Analysis. There’s a demo report we have. So, let’s talk a little bit about, MTHFR. So, we actually have a map called a methylation map. Now, what happens is, when you do your saliva test, you, you know, you spit, you put some saliva. in a collection kit, goes to a lab, takes out the DNA data, sends it to the computer, and now you can actually see it visually. Okay. So, it’s gonna take a second for this, data to load up, it’s, and each of these Circles, each of these ovals, is an enzyme. And the data gets loaded up to see where it is. So, until it gets loaded up here, I didn’t preload this. There it goes. So… The primary thing about methylation is There’s a nasty substance called homocysteine that, if it’s too high, can really be detrimental. The body takes methylfolate, and combines with methyl B12, To bring this back up to methionine. And then through the MAT genes, we make SAMI, S-adml methionine. Which is involved in so many processes. Then after it does its thing, it turns back into homocysteine. And this thing needs to keep spinning around. That’s why, you know, it’s a good idea to keep homocysteine at, do you have a number that you’d like? 7, 8? What do you like for a number? Dr. Deb Muth 00:55:24 Yeah, I like mine below 7. Bob Miller 00:55:26 Yeah. So if the homocysteine goes too high. It, caused all kinds of problems. So, here’s where you ask about the MTHFR. So, here you can see on this individual. I click on MTHFR, and you can see it comes up here, here’s the C677. And you can see here where it says, variants. I’ll… I’ll draw in case somebody’s having a hard time seeing that. So, you can see there’s nothing in there. That means there’s no genetic mutations. If one parent would have given a mutation, there’d be a 1. If both parents did, there’d be a 2. Now, here’s why Yes, methylation is important, I’m not saying it isn’t important, but look at this MTHFRC677. In my software. Only 42.5% of the population does not have a mutation. 44.7% have won. 12.9 have 2. So, this isn’t some rare, oh my god, I’m gonna die… Kind of thing, yeah. Dr. Deb Muth 00:56:27 Right. Bob Miller 00:56:28 So, And then what happens is that, and again, I’m not dismissing methylation, I… we could do a whole show on methylation. Bob Miller 00:56:36 get it. But I think that what people are doing is they’re, they’re learning about MTHFR, they get it measured, they panic. They start taking massive amounts of methylfolate, which many times is to their detriment. Dr. Deb Muth 00:56:50 Well, it’s… and isn’t it true, too, with MTHFR, like, you have to also look at MTR, MTRR, and the more we stack up of those, the more complicated than MTHFR can be. It’s not… it’s not as simple as just saying MTHFR 677 versus 1298. It’s more complex than that, kind of like what you’ve already shown with some of the other things. There’s more to it than just that one little sliver. Bob Miller 00:57:17 Oh, sure, well, let’s take a look. So, remember I said there’s a cofactor? One of the cofactors is called FAD. Just a Bob Miller observation, that’s all. But when people have trouble with their riboflavin and they don’t have enough FAD, They’re doing much worse than people who have just a C677. So, right here, you could have perfect C677th. And if you don’t have the cofactor, it’s not gonna work, okay? Dr. Deb Muth 00:57:48 And as you said, there’s an MTR enzyme. Bob Miller 00:57:51 that takes methylfolate and methyl B12, to spin it around. So, here on this individual. here’s your… here’s your B vitamins, or I’m sorry, your B12s. There’s an enzyme called TCN1 that takes it from the stomach into the blood. Then there’s other enzymes that take it from the blood into the tissue. And if you’re having trouble here. Well, then you’re not going to have this working, so… Even if you don’t have MTHFR, And you have MTR, like this, no, I’m sorry, this person doesn’t. But they have the MTRR, and then they don’t have enough B12, this isn’t gonna work, aside from that. And then there’s a middle pathway. And then there’s enzymes called the MAT1. they take the methionine to the salmon. If that’s not working, we stick… we get stuck in methionine. So, it’s, it’s not just an MTHFR. And then, one of the things that people forget about. is through these CBS enzymes and CTH, We make cysteine, which is needed to make glutathione. The master antioxidant. So, it really is that… I call it the, The 3D chess game played underwater. Dr. Deb Muth 00:59:07 It really is. I mean, I see people who have CVS, COMT, glutathione, MGHFR genes. And some of them function just fine. Like, they have Like, I look at this person and I’m like, oh my gosh, I don’t know how they’re functioning because they’re double mutated on so many pathways, but yet they don’t have a lot of symptoms, they don’t have a lot of complications. Somehow their body has figured out a way to adapt to what it has so it can stay alive and it can function at a high functioning level. Bob Miller 00:59:36 Yeah, and they may be, you know, eating right? Yeah. Staying out of a moldy house. reducing stress. So, it’s diet, it’s stress, it’s genetics, environmental factors. So, yeah, we can’t just say somebody’s gonna be good or somebody’s gonna be bad. You know, some people get scared, oh, I got all these, it’s like, well… Bob Miller 00:59:56 Are you living in a moldy house? You know, and if you live in a moldy house and your glucuronidation pathway doesn’t do well, or if you’re, you know, a smoker, or you’re constantly eating junk food, I mean, all. Bob Miller 01:00:07 things come together. Although, you know, when we focus on genetics, we’re well aware that this is just a piece of it. You know, you could have identical twins, Genetically, and if one… Is exposed to mold and smokes and drinks and stressed out. They’re gonna be a whole lot sicker than their sibling. Bob Miller 01:00:28 Yep. Dr. Deb Muth 01:00:29 Yeah, it’s that concept of taking twins, and one gets raced with one family, and one gets raced with another family, and they don’t have the same… problems that… that each other have, you know? It’s a very unique situation, we don’t think about that enough. Bob Miller 01:00:44 Alright, so again, genetics loads the gun, environment pulls the trigger. So, if you’ve got a loaded gun, but you don’t have the triggers, you’re okay. Dr. Deb Muth 01:00:53 Yeah. Bob Miller 01:00:54 Yeah. So, remember I said I was going to talk about NAD? So, here’s NAD, and what it does, it turns into NADH. And what NADH does, it, Comes down this pathway, what’s called the electron transport chain. And that makes your ATP, that’s your energy. So, if this wasn’t working, we wouldn’t be alive, because we wouldn’t have energy. So it donates an electron, that’s why it’s called electron transport chain. So, we need NAD, To make this, to make the energy. But remember I said that NQ01, this would probably be, like, on my top 10 list of… Bob Miller 01:01:36 Much more important than MTHFR. This one takes NADH back to NAD. If we’re stuck over here, We’re low in this NAD+, But what happens is, NQO1 also provides CoQ10. And CoQ10 Is what’s needed for the electron transport chain to flow. So if we get too many electrons up here. And they don’t turn them into energy. They make a nasty free radical called superoxide. Okay. Now, NAD plus also makes NADPH, And that is needed. Remember I said we need to recycle our antioxidants. So, if we have a problem with FAD from riboflavin. Yeah, we don’t have enough NADPH, Glutathione’s not getting recycled, and you’re gonna be inflamed. And you take glutathione, you’ll feel worse. There’s another enzyme called thimoredoxin. Same thing, needs NADPH and FAD. And same way with your nitric oxide, there’s an enzyme called NOS3, That makes the nitric oxide that dilates your blood vessels. And if we don’t have enough NADPH or fat, You’re gonna make superoxide. Rather than nitric oxide. Now, remember

Jesus taught in the Sermon the Mount that God loves completely, and that we ought also love completely. What does that mean in a culture of pervasive and rising Christian Nationalism? Along with our Menno kin across the conference, we have pledged ourselves to “Christian Discipleship” in the midst of Christian Nationalism. We are meant to follow Jesus, to love completely, to cause no harm. We are meant to resist, disrupt, and challenge the culture of violent, harmful, and power-hungry Christian Nationalism all around us. Relying on Mennonite scholar Drew Strait's work, we lift up the following: 1) break silence, 2) lament, 3) define Christian Nationalism, 4) identify political idolatry, 5) preach the whole life of Jesus, 6) activate congregations.Sermon starts right away Matthew 5.46-48Resources:A Call to Christian Discipleship Amidst a Culture of Christian Nationalism, a resolution passed by the delegates to Pacific Northwest Mennonite Conference (PNMC) in 2025Companion Worship Resource, created by a team from PNMC to accompany the 2025 resolutionDrew Strait, “How to Challenge Christian Nationalism: Building Peace in an Age of Extremism,” sharing insights in Oct 2024 from his book, Strange Worship: Six Steps for Challenging Christian Nationalism (Cascade, 2024). Drew Strait, “Political Idolatry: a group study” a 30-minute version of a longer webinar on political idolatry and White Christian nationalism. Read more on “What is Christian Nationalism” on the AMBS website: https://www.ambs.edu/political-idolatry/Rev. Dr. Martin Luther King, Jr., “In the end, we will remember not the words of our enemies but the silence of our friends.” Commentary on the original source found here.Kimberlé Crenshaw, “Where there's no name for a problem, you can't see a problem, and when you can't see a problem, you pretty much can't solve it.” More at “Race, Colonialism, and Diaspora Studies” of Tufts University.“God's Army is Hiring,” Kate Burns, The Stranger, June 4, 2026.Image: cover for Drew Strait's book, Strange Worship, source material for sermon

John Crist joins Willie Robertson and Uncle Si for what turns into a roast of John's Mennonite background, homeschool education, and large family. The guys swap their most awkward fan encounter stories, and John gets Willie to admit to a few intrusive thoughts he didn't even realize he had. John shares the biggest comedy fail of his career, Si discovers he may be in possession of Willie Nelson's autograph, and Willie confesses to a Topgolf prank that caused chaos in real time. Duck Call Room episode #558 is sponsored by: https://trybeef.com/duck — Get 10% off your first TriTails box straight from their ranch to your door. https://myphdweightloss.com — Find out how Godwin is losing weight! Visit the website or call 864-644-1900 and mention "Godwin" to get 2 weeks free in the program! Get bugs out of your house with Pestie. Go to https://pestie.com/DUCK for 10% off your order. https://fastgrowingtrees.com/duck — Get 20% their first purchase when using the code DUCK at checkout. - Learn more about your ad choices. Visit megaphone.fm/adchoices

This special episode features two new Pennsylvania Oddities stories, plus Episode 1 of my new short-form true crime podcast, 15 Minutes of Infamy.Part I: The Psychiatrist's Fatal FollyDuring the early history of Rockview State Penitentiary in Centre County, the homes of prison officials were tended by the most trusted and deserving inmates, who served as domestic servants. But things changed in 1932, after the daughter of a prison psychiatrist was stabbed by a "mentally deficient" convict named Fred Collins.Part II: The Deathbed Confession of Hetty GoodIn 1895, when a sweet old Mennonite woman found herself on death's doorstep, she made an astonishing claim with her dying breaths-- that she was one of the most ruthless killers Lancaster County had ever seen. Part III: A Black Hearse Comes at MidnightThe Archer Home for Elderly People was a highly-specialized business. That is, it specialized in the quick and speedy extermination of its residents.This is the shocking true story of Amy Archer Gilligan, the Connecticut nursing home owner who earned her fifteen minutes of infamy after a suspicious newspaper reporter noticed that a mysterious black hearse visited the home every midnight to spirit away the bodies of her victims.

Elsa Jean joins Lip Service to talk about her wild dating history, Vegas weddings, sugar daddies, celebrity relationships, stalking experiences, OnlyFans money, therapy, heartbreak, and surviving toxic love. She also opens up about growing up Mennonite, working in the adult industry, fertility struggles, and why she still believes in marriage.See omnystudio.com/listener for privacy information.

Late Show - Legends, Tales, and Folklore of the Amish Mennonite and Pennsylvania DutchBecome a supporter of this podcast: https://www.spreaker.com/podcast/missing-persons-mysteries--5624803/support.

Maria Giesbrecht shares her gorgeous poetry in A LITTLE FERAL. Written in the aftermath of leaving a conservative Mennonite upbringing, these poems chart a parallel journey of breaking away— from father, from God, from the confines of obedience.

Welcome back to Patty's Playhouse! In this laid-back weekend episode, Patty, Scott, and Jason bounce between Tallahassee happenings, local food finds, funny personal stories, and real estate updates.The conversation covers everything from Mennonite bakeries and strawberry pie to food trucks, graduation weekend chaos, and the challenges of driving a right-hand-drive vehicle through a parking garage downtown. Along the way, the crew shares laughs about local restaurants, Tallahassee events, quirky observations, and everyday life around town.This episode also includes:Local weekend events and community happeningsFood truck favorites and restaurant talkGraduation weekend in TallahasseeFunny driving and parking storiesReal estate listings and market updatesInsights into appraisals, AI tools, and fair housing language in real estateIt's a casual, funny, community-centered episode full of Tallahassee flavor, local conversation, and the kind of stories that make Patty's Playhouse feel like hanging out with friends.add emojisWelcome back to Patty's Playhouse!

Tony Eash runs Triple E Farms in West Virginia with his brother Phil - a raw dairy and pasture-raised operation built from bare land, rooted in regenerative principles and faith in community.Farmer Stories pulls the best conversations from The Regenaissance archive - real voices from American farmers on the systems, economics, and communities shaping food and land in the US.Timestamps:0:00 — Why farmers not making money is everyone's problem1:00 — What on-farm milk testing actually costs2:00 — Building a farm from scratch while working full-time5:00 — Quitting time: 10:30pm. Wake up: 3:30am6:30 — Why they walked away from pigs and chickens8:00 — How the Amish moving in changed everythingConnect with Triple EWebsiteInstagramWatch full episodeFollow the tour on YouTube

In this week's episode, I'm joined by poet Maria Giesbrecht to talk about her debut collection, A Little Feral. The collection was written after leaving a conservative Mennonite upbringing, and her poems explore themes of faith, family, and personal resurrection. Maria and I started the conversation with her background in corporate accounting and the catalysts to her being a full time poet, piecemealing her way into a freelance writing career with the support of her life partner. A Little Feral's emotional arc captures the process of purging parts of her past, accepting that she might never feel whole, and that that is enough. This leads us into a discussion about the righteous anger of women during our current times, using that feral part of ourselves to move the needle for women's rights. We talk about Maria's writing style, where she details her current writing habits for keeping the channel open and how that routine helps keep her writing on track. Maria goes into a little bit of detail about her relationship with her writing gods and how showing up regularly is imperative to keeping the channel active.We round out our conversation with a quick digression into Maria's MFA topic and her hope to capture parts of her past within the laborer community and the guilt that can come with stepping into spaces or stages our loved ones can't or don't understand.You can buy A Little Feral now: https://bookshop.org/a/54661/9781949342819You can learn more about Maria Giesbrecht here: https://mariagiesbrecht.com/If you have an author, book, or topic you want to hear about on the podcast, then don't hesitate to slide into my DMs on Instagram or shoot me an email!Subscribe to my newsletter to keep up to date on the latest podcast happenings: https://in-bed-with-books.kit.com/76d11f1d51Where else to find me:IG: @inbedwithbookspodYT: https://www.youtube.com/@InBedWithBooksPodEM: inbedwithbookspodcast@gmail.com

Episode 2795 - Vinnie Tortorich and Chris Shaffer welcome four callers to discuss eating while on chemo, weight-loss goals, how to keep on keeping on, and more. https://vinnietortorich.com/2026/05/keep-on-keeping-on-episode-2795 PLEASE SUPPORT OUR SPONSORS Pure Vitamin Club Pure Coffee Club NSNG® Foods VILLA CAPPELLI EAT HAPPY KITCHEN YOU CAN WATCH THIS EPISODE ON YOUTUBE - @FitnessConfidential Podcast Vinnie's workout videos are available to purchase! Choose from a 2-day, 4-day, or 6-day workout–or buy all three at a discount! TO PURCHASE VINNIE'S WORKOUT VIDEOS, CLICK THIS LINK: https://vinnietortorich.com/workout Keep On Keeping On Dave is the first caller. (3:30) He was recently diagnosed with cancer and called ot give an update. He's managed to keep weight on despite having to eat liquid foods. Vinnie gives him some advice about eating while getting chemo. (8:30) John W is the second caller. (15:30) He's been NSNG for several years now and has noticed that his PSA levels go up if he has carbs. (17:30) PSA is a test to measure prostate antigens as a way of monitoring prostate health. He has a question about HIIT training. (24:00) HIIT training is not the same as strength training. They touch upon a spiritual mindset about life. (35:00) He has a question about how to share information about NSNG® with the Amish and Mennonite communities. (38:00) If you haven't already, you can purchase Vinnie's Intro to NSNG e-book. https://nsng.vinnietortorich.com/product/intro-to-nsng/ Brandon is next. (48:30) He grows his hair to donate to kids with medical issues who have lost their hair. He called Vinnie because he can't seem to get to the next step to reach a lower weight and has a hard time imagining himself at an optimal weight. (1:02:00) John D is the final caller. He's lost a lot of weight on NSNG® in a short time; however, he feels his weight loss is slowing. Where can he make changes to keep the loss going? Creatine can increase your energy. (1:27:00) The NSNG® VIP GROUP IS NOW CLOSED AGAIN AS OF SUNDAY, MARCH 15TH Anna's next cookbook, Eat Happy Cocktail Hour, is filled with cocktails, mocktails, and appetizers and is available for pre-order right now. If you pre-order, you'll get bonus goodies! You can preorder from a wide variety of booksellers at https://eathappycocktailhour.com/ Save your receipt from wherever you preorder, you'll need it for your bonuses! Physical Release Date is October 2026 A New Sponsor Jaspr Air Scrubbers has a discount code, VINNIE, that gets you $200 off for a limited time. Jaspr offers a lifetime warranty. Go to Jaspr.co for more information or to purchase. (1:05:00) You can book a consultation with Vinnie to get guidance on your goals. https://vinnietortorich.com/phone-consultation-2/ More News Serena has added some of her clothing suggestions and beauty product suggestions to Vinnie's Amazon Recommended Products link. Self Care, Beauty, and Grooming Products that Actually Work! https://www.amazon.com/shop/vinnietortorich/list/3GPVU29UHHPMY?ref_=aipsflist Don't forget to check out Serena Scott Thomas on Days of Our Lives on the Peacock channel. "Dirty Keto" is available on Amazon! You can purchase or rent it here.https://amzn.to/4d9agj1 Please make sure to watch, rate, and review it! Eat Happy Italian, Anna's second cookbook, is available! You can go to https://eathappyitalian.com You can order it from Vinnie's Book Club. https://amzn.to/3ucIXm Anna's recipes are in her cookbooks, on her website, and on Substack —they will spice up your day! https://annavocino.substack.com/ PURCHASE DIRTY KETO (2024) The documentary launched in August 2024! Order it TODAY! This is Vinnie's fourth documentary in just over five years. Visit my new Documentaries HQ to find my films everywhere: https://vinnietortorich.com/documentaries Then, please share my fact-based, health-focused documentary series with your friends and family. Additionally, the more views it receives, the better it ranks, so please watch it again with a new friend! REVIEWS: Please submit your REVIEW after you watch my films. Your positive REVIEW does matter! PURCHASE BEYOND IMPOSSIBLE (2022) Visit my new Documentaries HQ to find my films everywhere: https://vinnietortorich.com/documentaries FAT: A DOCUMENTARY 2 (2021) Visit my new Documentaries HQ to find my films everywhere: https://vinnietortorich.com/documentaries FAT: A DOCUMENTARY (2019) Visit my new Documentaries HQ to find my films everywhere: https://vinnietortorich.com/documentaries

Sam Shetler Case: Missouri Amish ‘Counselor' Accused of Abuse, Forced Labor, and Fraud Tonight we're taking a hard look at the Missouri case involving Sam B. Shetler, an Amish retreat operator now facing a long list of serious criminal charges. According to court records and reporting, investigators say Shetler ran a retreat called Mercy and Truth in Cooper County, Missouri, where Amish and Mennonite residents were sent for counseling, therapy, or help — but prosecutors now allege that many were instead abused, manipulated, sexually exploited, and forced to work for free. Shetler has pleaded not guilty. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

NOTE: Since the time of this recording, Community Harvest SRQ has merged with Sunshine Community Compost to form Sunshine Community Harvest.Andrew Hudson is on a mission. An organic gardener and program director for the nonprofit organization Community Harvest SRQ, Andrew wants to connect the people of Sarasota with its local food.Dalia met Andrew through a mutual friend, Chef Steve Phelps of Indigenous Restaurant. Steve describes Andrew as “rebooting the community food system in Sarasota.” So of course I wanted us all to meet him.As Andrew explains in this conversation, he connects restaurants and neighbors to get surplus produce off the field and onto people's plates. We also dig into Sarasota's Eat Local Week, food sovereignty and what it means to give communities more control over what they eat. As I learned in this conversation, Andrew is also a Mennonite minister. So he brings a really thoughtful perspective to the sacredness of food and the idea of giving farmland time to rest. He reminds us all that caring for the soil and each other go hand in hand.

In tonight's dead letter, a peaceful retreat at a friend's historic property in the country yields a brush with something that defies explanation. The old homes in these rural communities are steeped in generations of human memory, and sometimes, those overlaid paths from the past seem to bleed right through the present day. We unpack an incredibly vivid, solid sighting that leaves us questioning the true nature of time, space, and the boundaries of our own backyards.REFERENCE LINKSThe Finger Lakes RegionHistory of the Amish and Mennonite SchismSpolia in ArchitectureBelhurst Castle and the Lady in WhiteAl Jaffee and the Mad Magazine Fold-InWe're looking for more stories! Send your Dead Letter to deadletteroffice@astonishinglegends.com!

After World War II, Puerto Ricans began settling in Pennsylvania Dutch Country, drawn by economic opportunities among Mennonite farming communities. Several generations later, they’re honoring their history and reclaiming their identity as “Dutchiricans” within the Mennonite church—and beyond. Tune in to listen to the story of a Dutchirican matriarch —from her family’s migration from Puerto Rico to their adoption of the Mennonite faith— and how spirituality, work, and resilience forged a new cultural identity. Latino USA is the longest-running news and culture radio program in the U.S., centering Latino stories and hosted by Pulitzer Prize-winning journalist Maria Hinojosa. Follow the show to get every episode. Want to support our independent journalism? Join Futuro+ for exclusive episodes, sneak peeks and behind-the-scenes chisme on Latino USA and all our podcasts. Follow us on TikTok and YouTube. Subscribe to our newsletter. See omnystudio.com/listener for privacy information.

Late Stream - AMISH MENNONITE and PA DUTCH: Folklore Witchcraft Secrets and MOREBecome a supporter of this podcast: https://www.spreaker.com/podcast/missing-persons-mysteries--5624803/support.

Episode 2.102In this episode of Cults, Michael and Zach examine the Amish—a unique Anabaptist tradition known for simplicity, separation from modern culture, and strong community life. Rather than asking whether the Amish are a different religion, the episode focuses on a more precise question: how their theology and practice align with the biblical gospel and the authority of Scripture.The discussion walks through Amish beliefs across key areas including theology proper, Christology, and especially soteriology, where concerns begin to emerge. While the Amish affirm historic Christian doctrines about God and Christ, their understanding of salvation often emphasizes obedience, community membership, and conformity to the Ordnung, with less clarity around justification by faith alone and assurance of salvation.From there, the episode explores authority and practice—highlighting how Scripture, tradition, and community expectations function together, often elevating extra-biblical rules to binding status. Topics such as technology restrictions, shunning, and pacifism are examined not just culturally, but theologically. The episode concludes with a brief comparison to Mennonites and a balanced assessment of both strengths and concerns.The takeaway is straightforward: the Amish preserve important elements of historic Christianity, but where authority shifts toward tradition and salvation becomes tied to performance, the clarity of the gospel and the sufficiency of Scripture are put at risk.Find our videocast here: https://youtu.be/09clBAimUfkMerch here: https://take-2-podcast.printify.me/Music from #Uppbeat (free for Creators!):⁠https://uppbeat.io/t/reakt-music/deep-stone⁠License code: 2QZOZ2YHZ5UTE7C8Find more Take 2 Theology content at http://www.take2theology.com

John 17:14–23,14 I have given them your word, and the world has hated them because they are not of the world, just as I am not of the world. 15 I do not ask that you take them out of the world, but that you keep them from the evil one. 16 They are not of the world, just as I am not of the world. 17 Sanctify them in the truth; your word is truth. 18 As you sent me into the world, so I have sent them into the world. 19 And for their sake I consecrate myself, that they also may be sanctified in truth. 20 “I do not ask for these only, but also for those who will believe in me through their word, 21 that they may all be one, just as you, Father, are in me, and I in you, that they also may be in us, so that the world may believe that you have sent me. 22 The glory that you have given me I have given to them, that they may be one even as we are one, 23 I in them and you in me, that they may become perfectly one, so that the world may know that you sent me and loved them even as you loved me.Last week, I said that John 17 is one of the most amazing chapters in all the Bible (because the whole thing is a prayer that Jesus prays for us). And I just wanna start this week by saying that I'm in no hurry to be done with it. We're gonna eventually get to Chapter 18, but for the next two weeks we're gonna stay in Chapter 17, and today I want us to pay special attention to how Jesus talks about us — There is so much in this prayer that we learn about Jesus and about his relationship to the Father, and it's as deep as it gets! It's glorious! But also, as we're listening in on this prayer, we hear Jesus say some important things about us as his people. And he doesn't just say random facts, but they're more like defining realities of who we are as the church — and they're defining realities that Jesus gives us in direct connection to himself. We can see that grammatically each time Jesus uses the word “as” or “just as.” He says three different times about us: “They are this, JUST AS I am this.” Or “AS this is true of me, this is true of them.”He names three defining realities this way, and I'll go ahead and tell you what they are. He says:We are separated. We are sent.We are one. We're gonna look at each of these. Let's start with the first.1. We are separated (verses 14–17).Look again at verse 14:I have given them your word, and the world has hated them because they are not of the world, just as I am not of the world. 15 I do not ask that you take them out of the world, but that you keep them from the evil one. 16 They are not of the world, just as I am not of the world.We all just heard that. It's straightforward. Jesus says: “They are not of the world, just as I am not of the world.” And he says it twice, in verses 14 and 16! Which means there's an emphasis.If Jesus is our teacher (and he is), and if this prayer is meant to teach us (and it is), then Jesus wants us know about our relationship to the world: We are not of it.Every Christian must agree with that in principle, because Jesus says it. In basic terms, we as Christians, the church, we have a negative relationship to the world. This same idea is repeated all throughout the New Testament — Pauls says in Romans 12:1, “Do not be conformed to this world…” James says in James 4:4, “Friendship with world is enmity with God…” John says in 1 John 2:15, “Do not love the world or the things in the world. If anyone loves the world, the love of the Father is not in him.”What Is the ‘World'?These are strong statements, and clear statements — we just have to make sure we understand the meaning of “world.” When Jesus says “world,” what's he talking about?The best way to think about the meaning of “world” is to think of it as the realm of human values, ideas, and effort that, because of sin, is in active rebellion against God.The biblical image for the world is Babylon. Or it's what Augustine calls simply the City of Man. Or another way we sometimes talk about the idea of the world is with the word “culture.”In fact, back in 1951, theologian Richard Niebuhr wrote a famous book called Christ and Culture — in it he described different approaches the church has historically taken toward culture. But when he defined culture, he defined it as “what the New Testament writers frequently had in mind when they spoke of ‘the world'…”In the New Testament, the world is not the earth; it's not a globe; it's not a bunch of individual people — but it's a realm. It's a realm of values, ideas, and effort.And it's a realm that Christians are NOT OF — Jesus tells us. But why are we not of the world?Called Out and Set ApartWe're not of the world because, as we saw last week in verse 6, the Father has called us out of the world and he has given us to the Son, who is not of this world. So we now belong to Jesus who is not of this world. That's how God has separated us from the world.We belong to Jesus and Jesus has given us his word. And that is what makes us different! It's verse 17:“Sanctify them in the truth; your word is truth.” We are set apart by the truth: we have the gospel! We have the true revelation of God! We have eternal life! The world does not have this, and in fact, it's because we have it that the world hates us. That's verse 14.And Jesus has already told us this. In Chapter 15, verse 18, he says:“If the world hates you, know that it has hated me before it hated you. If you were of the world, the world would love you as its own; but because you are not of the world, but I chose you out of the world, therefore the world hates you.”Look, I don't know how Jesus could be more clear. Christian, you are not of the world … because God has separated you from the world … and the world hates you. That is what's going on outside here with these people who line up on Sundays. These people are against you; they do not seek your good; they do not want us here. They're full of hate. And we're gonna be okay. Because they're just proving what Jesus has already taught us. If we're paying attention to the New Testament, we should not be surprised by this. The world hates us. Jesus says that. And yet, I'm a little concerned that when we hear this kind of message we can instantly write it off and give it a name like Fundamentalism. We can think: Just relax. You're overdoing it.But how dare we think such a thing when our Savior is so clear. Jesus tells us we have a negative relationship to the world in that we are not of the world and the world hates us. We must listen to him. Understand what Jesus is telling us about who we are, and he starts by saying we are separated from the world. We start here. But then … a second defining reality:2. We are sent (verse 18).This is verse 18:“As you sent me into the world, so I have sent them into the world.”Jesus already said in verse 15 that although we are not of the world, he is not asking the Father to take us out of the world. We're still in this realm, because Jesus wants that for now. And in verse 18 Jesus says more. He says: We're not just here, but he has sent us here. So get this: If you are a Christian in this world, you're here because Jesus has sent you here. You're not of the world, but you've been sent into the world.This is the phrase: Not of, but sent into.Life-Changing RephraseFor me, personally, that phrase has changed my life. I mean that. True story… Before I proposed to Melissa, we were in North Carolina, and I told her we were gonna move to Minneapolis for two years. It was gonna be two years for a pastoral training program, and then seminary somewhere else, and then wherever God calls us. That was eighteen years ago.And under God, one of the big reasons we sensed him calling us here was David and Megan Mathis. Years ago I worked with David at Desiring God, and we did some writing together, and I remember one day David had this idea for a blog series (y'all remember blogs?).This was gonna be a blog series on the church's mission, and David's first article to launch the series was titled “Getting the Accent Right: ‘Not Of, But Sent Into.'” Have any of y'all ever heard the saying that Christians are “in the world, but not of the world” — in, but not of.Well, David thought it was inaccurate with what Jesus says in John 17. So he had this idea: he said let's change the phrase! Let's reinvent this popular saying! (David was just 30 back then). He said: instead of saying in, but not of, let's change it to say not of, but sent into — “not of the world, but sent into the world.” That's the new way to say it! We were gonna change the Evangelical church in America!I don't know if y'all have ever read David's article or heard his rephrase, but since that day I have never thought of John 17:18 any other way.We are not of, but sent into. That's what Jesus says! That's why I'm here. That's why we're here. Jesus has sent us into this world — and sent us how? Sent us with what?Sent with What?Well, Jesus says he has sent us just as the Father has sent him. There is a sameness in our sending. Now we shouldn't misunderstand the sameness: the Son does what only the Son can do! Only the Son can truly save! But the sameness is seen in our message. Jesus came here to reveal God and redeem people to God. That was his mission, and he now sends us here as part of that mission, to tell of what he did. The Father sent Jesus here to accomplish the gospel. Jesus now sends us here to tell that gospel. Not of the world, but sent into the world with the gospel.That's who we are, church! We are sent — and sent for this purpose. It is the gospel that makes us unique and different from everything else in the world. There are lots of other good things a local church might do in a city, but Jesus sets us apart by the gospel. That's what he says in verse 19. We have been “sanctified in truth” — another word for sanctified is consecrated. Jesus has consecrated us for the mission of offering life and light to a dead and dark world by pointing to him. He has sent us here to witness to the surprising love of God — that God so loved the world that he gave his only Son that whoever believes in him shall not perish but have eternal life. This is the message we carry in our commission to Go and make disciples.We Must Be About the GospelPlease understand: this is not optional. Churches don't get to choose whether they're involved in this mission or not. To be a church is to have this mission — to be not of, but sent into the world with the gospel.The stakes could not be higher.If you know our church, you know that we're not a ‘political church' (in terms of what most people mean by that). But instead, we're all about the gospel. And listen: we must be that. Because here's the thing: if a church is withdrawn from politics and culture wars because they're all about the gospel, but then they don't really go share the gospel, they might as well just be Amish. … I meant that. Because Amish (or Mennonite communities and others like them) are built on a theological approach to the world that is extreme separation. This approach understands the “not of” part in John 17; they're missing the “sent into” part. But see, we understand the sent into part. We just need to keep being clear on why we're sent into the world.It's not mainly so that we get to dress the way we do … or cheer on our favorite sports team or drive our vehicles or watch our shows or use our phones … if those are the only reasons we're not like the Amish, we're doing it wrong. Jesus sent us into the world with the gospel! We are here to make him known to everyone who is willing to listen! That is why we are sent. We are separated from the world, yes — and we are sent into the world with the gospel. This a defining reality of who we are.Now, the third defining reality Jesus gives us …3. We are one (verses 19–23).And I want you to hear this again in verses 20–23:I do not ask for these only, but also for those who will believe in me through their word, 21 that they may all be one, just as you, Father, are in me, and I in you, that they also may be in us, so that the world may believe that you have sent me.22 The glory that you have given me I have given to them, that they may be one even as we are one, 23 I in them and you in me, that they may become perfectly one, so that the world may know that you sent me and loved them even as you loved me.It's easy to pick up a theme in these verses. The idea of oneness is mentioned four times. And the word we use for this is unity — which is really important. We need to think carefully about it. Two things to consider: What kind of unity is Jesus talking about? What is the unity for?What Kind of Unity?One thing that the 21st century has in common with the First Century is that our societies both have its own concept of unity. Remember that Jesus is speaking all of this in a Greco-Roman world, and they valued unity. It was a value then kinda like it is today. And you know what I mean. “Unity” is a buzz word. It's the kind of word that the NFL might put on their helmets, or make all the coaches to wear a shirt that says “Unity.” We've seen this before. And at first glance, we might think: Well this is great! Jesus obviously values unity, and our world values unity, so see the world can't be that bad. The world has a biblical value.And that is possible! Over time, Christian values can (and should) influence and transform the values of society (that would be good for society). But just because the same word is used doesn't mean it's the same value — the devil is in the details, literally.And the details of worldly unity is that it's really about coercive ideological uniformity. Worldly unity is a forced sameness of thought that's engineered and held in check by social threats.I remember one time another pastor blamed me as being against broader church unity because I believe what the Bible says about sexuality. He was basically saying I'm against unity because I was unwilling to defy the word of God — but does that mean I'm against unity? … No, I'm against worldly unity.That's not what Jesus is talking about, and he understands it exists. He knows he's in the world. He gets his context. So when Jesus describes unity, he's clear that it's unity from him and to him.The oneness he's talking about is not so much our oneness with each other, but our oneness with him. Our unity is not a Babel-like ground-up operation. It's a heaven-sent miracle experienced in our fellowship with the Trinity. That's the kind of unity Jesus means — “unity controlled by, defined by, and shared by the unity of the Father and the Son” (Klink, 724). And it's unity with a purpose. What Is the Unity For?Jesus tells us this twice, in verse 21 and 23:In verse 21, Jesus asks for the Father to make us one “so that the world may believe that you have sent me.” In verse 23, it's “so that the world may know that you sent me and loved them even as you loved me.”These verses are saying the same thing. The purpose of our unity is so that the world would see it and know Jesus — so that the world would know that God loves his people … and that those of the world can become his people through faith in Jesus. People of the world become not of the world when they trust in Jesus. They're called out of the world, separated by God, and then Jesus sends us into the world with the gospel. And we do it together with him, filled by his Spirit, welcomed into his fellowship. Church, this is who we are. Separated, sent, one. And my prayer is that in these days we would not shrink back from these defining realities, but that we would embrace them anew. That we would not only endure, but that we would advance.His word shall not fail you, he promisedBelieve him and all will be wellThen go to a world that is dyingHis perfect salvation to tell.That's what brings us to the Table.The TableAs we take the bread and the cup, we remember the death of Jesus for us, and we remember who he has made us to be. He has saved us and given us a mission. Grace upon grace.If you're a Christian, if you trust in Jesus Christ, we invite you to eat and drink with us and give him thanks!

Last time on The Normals, we learned that in the 1950s, the National Institutes of Health (NIH) wanted to recruit many healthy volunteers for basic research. Two peace churches, the Mennonites and the Church of the Brethren, had an excess of healthy human volunteers. The “Normals” recruited from these Anabaptist churches were surprisingly happy, even as they went through sometimes painful procedures. In this follow-up episode, we hear about how the sources of normal human subjects changed in the 1960s and why NIH researchers felt they needed to expand their search for normal people. We also learn about the first death in the program and the shifting motives on the parts of the researchers and volunteers. Final episode drops next Tuesday, April 21. All Normals episodes In this episode: Laura Stark, history professor at the Center for Medicine, Health, and Society at Vanderbilt University Ken Naas, former Normal patient Cindy Jansen, former Normal patient Dale Horst, former Normal patient Sarah Crespi, Science Podcast senior host and producer Additional resources: The Normals: A People's History of Modern America in Five Human Experiments by Laura Stark Learn more about your ad choices. Visit megaphone.fm/adchoices

Last time on The Normals, we learned that in the 1950s, the National Institutes of Health (NIH) wanted to recruit many healthy volunteers for basic research. Two peace churches, the Mennonites and the Church of the Brethren, had an excess of healthy human volunteers. The “Normals” recruited from these Anabaptist churches were surprisingly happy, even as they went through sometimes painful procedures. In this follow-up episode, we hear about how the sources of normal human subjects changed in the 1960s and why NIH researchers felt they needed to expand their search for normal people. We also learn about the first death in the program and the shifting motives on the parts of the researchers and volunteers. Final episode drops next Tuesday, April 21. All Normals episodes In this episode: Laura Stark, history professor at the Center for Medicine, Health, and Society at Vanderbilt University Ken Naas, former Normal patient Cindy Jansen, former Normal patient Dale Horst, former Normal patient Sarah Crespi, Science Podcast senior host and producer Additional resources: The Normals: A People's History of Modern America in Five Human Experiments by Laura Stark Learn more about your ad choices. Visit megaphone.fm/adchoices

Stories of the AMISH MENNONITE and PA DUTCH - Folklore Witchcraft Secrets and MOREBecome a supporter of this podcast: https://www.spreaker.com/podcast/missing-persons-mysteries--5624803/support.

STRANGE TALES of The Amish - Pennsylvania Dutch - Mennonites - LEGENDS & FOLKLOREBecome a supporter of this podcast: https://www.spreaker.com/podcast/missing-persons-mysteries--5624803/support.

On review of this episode, I think I (Tyler) had to correct myself more in this 30 minutes than at any other point in my life. Apparently I need to study up on Quakers, Mennonites, the Amish, and the 12th ranked state.

Sundays are supposed to be special, but sometimes they just feel stressful. Today we bring you a little encouragement to help Sunday's go a little better. We discuss morning routines, lunch solutions, the benefits of resting vs. resetting, how we do or don't spend money and what a typical Mennonite Sunday looks like. Sunday's come around once a week and if you're at all dissatisfied with yours, we hope you enjoy this listen Thanks for being here!Jayna and MeganPlease check out our sponsors!Voetberg Music Academy:Use our code HOMEMAKER20 to get 20% off every month your family is enrolled and learn music in a way that sticks.https://www.voetbergmusicacademy.com/Cozy Earth:Go to https://cozyearth.com and use our code HOMEMAKER for up to 20% off.Wild:Thanks to Wild for partnering with us on today's video! Use code HONEYIMHOMEMAKER20 at https://shopwildrefill.com/HoneyImHomemaker-11 , and get 20% off all Wild products (refillable deodorant, body wash, lip balm, and hand wash)! Available worldwide!Watch our first 3 seasons: https://youtube.com/playlist?list=PLqdjqwDnpIMx_GhVzCWsT4LF-1EsRhwJm&si=8hmyDW0lI4-yWhQ-Please subscribe! You can also find this podcast on Spotify and iTunes!Shop Megan's lifestyle brand FoxSparrow over at www.meganfoxunlocked.comShop Megan's Amazon Storefront: https://www.amazon.com/shop/meganfoxunlockedShop Jayna's Amazon Storefront:https://www.amazon.com/shop/jaynalynnhandmade?ref_=cm_sw_r_apann_aipsfshop_aipsfjaynalynnhandmade_8JT0JHV8AH0KP8VJX5XN&language=en_USSign up for Scribd: (audiobook library): https://www.scribd.com/gitx/a33qb4(If you use this link you'll get a free month trial!)Chairs: https://www.walmart.com/ip/SINGES-Acc...Wallpaper: https://glnk.io/4x0x0/meganfoxunlockedgmailcomUse code MEGAN35Lamp: https://amzn.to/46Dyuy7Mustard throw: (the softest thing you've ever felt!) https://amzn.to/39CgZG2Contact/Collab: meganfoxunlocked@gmail.comP.O. BOX- send us some mail!P.O. BOX 9Akron, PA 17501Follow us on Instagram:Honey I'm Homemaker: https://www.instagram.com/honeyimhomemaker/ Megan: https://www.instagram.com/meganfoxunlocked/Jayna: https://www.instagram.com/jaynaburkholder/Megan's Business: https://www.instagram.com/shopfoxsparrow/Jayna's Business: https://www.instagram.com/jaynalynnhandmade/0:00 Low pressure hosting5:58 2000's are back9:45 Church attendance doesn't safe you13:45 Are we on time for church? - our morning routines16:10 Segregation at church22:22 Church flow at a Mennonite church 25:02 Wardrobe malfunctions after church 26:34 Hangry after church-- lunch solutions 31:34 Spending money on Sundays37:17 A restful Sunday "reset"37:15 Sunday scaries39:50 Stay at home mom perks on a Sunday41:33 Answering some of your questions Some links are affiliate links. Thanks for supporting my channel!Music from YouTube and Epidemic Sound

There are times in the world and in our lives when hope feels abstract. Maybe there's a little ironic detachment. Maybe it's more of a passive wish than taking action. And there's nothing wrong with wishing. But what I'm craving, and what I believe we need more than ever, is the kind of hope that gets its hands dirty. The kind that shows up–at community kitchens and school board meetings and in living rooms with our neighbors–that does not wait for the world to get better before jumping in. The kind of hope that asks, what is mine to do here?My guest today embodies that question in a way that stopped me in my tracks when we met last summer. Shirley Showalter's life has taken a path from her childhood in a buttoned-down Mennonite community to earning a PhD and becoming a distinguished professor of English, a liberal arts college president, and serving as vice president of the Fetzer Institute, where she spent years in conversation with some of the most thoughtful spiritual leaders in the world. And now, in what she calls her elderhood, she is still asking the question, what does it mean to belong to something larger than myself?In this conversation, Shirley and I talked about activism, elderhood, spiritual practice, what makes us blush, and the particular, peculiar, and unpredictable journey of becoming powerful and staying powerful across a lifetime.Listen to the full episode to hear:The deep joy and sense of belonging that Shirley found in nature as a child that she has carried and sought out throughout her lifeHow Shirley got involved in her hometown's school board and invited other community elders and educators to join herHow being an educator, servant leader, and activist has kept Shirley connected to the “barefoot feeling” of her childhoodThe mission statement that is guiding Shirley through her elderhoodThe practices Shirley engages with to connect a lifetime of experiences as she walks herself and others homeLearn more about Shirley Showalter:WebsiteFacebook: @ShirleyHersheyShowalterBlush: A Mennonite Girl Meets a Glittering WorldLearn more about Valerie Black:The Change AgencyBecoming Power NewsletterCoachingResources:"We Are All Just Walking Each Other Home," Blue Ridge Threshold ChoirLyrics by Ram Dass, originally by RumiMusic by Kate MungerModern Elder AcademyThe Fetzer InstituteI attended the Moms for Liberty summit. What I heard was an erosion of one of democracy's most important principles.Grandmas for LoveBill MoyersKrista TippettBlue Ridge Threshold Choir

STORMY MONDAY AMISH Sleep-In Stream - Folklore, Witchcraft, Secrets, and MOREBecome a supporter of this podcast: https://www.spreaker.com/podcast/missing-persons-mysteries--5624803/support.

Secrets of the AMISH - Pennsylvania Dutch - MennoniteBecome a supporter of this podcast: https://www.spreaker.com/podcast/missing-persons-mysteries--5624803/support.

Send a textHeat pressed down on Newton in August 1871 like a hand over a mouth, and by midnight the town was a fuse. We open on a drought-stricken railhead where class divides sharpened nerves, the dance band was sent home, and the room held its breath. Then everything snapped. Hugh Anderson strode into Perry Tuttle's hall and dropped lawman Mike McCluskey with a shot that turned a tense crowd into a battlefield. Amid the chaos, a coughing teenager named James Riley locked the doors, drew twin Colts, and harvested the room with terrifying precision—an unassuming figure who authored one of the bloodiest gunfights on the frontier and then vanished into the Kansas night.From there, the wires caught fire. Editors rebranded Newton as “Blooton,” feeding the East's appetite for frontier horror while reformers seized the carnage to push temperance and law. We dive into how correspondent E.J. Harrington—writing as Allegro—built a legend that sold papers, including the polished lie of the “Great Duel” where McCluskey's brother and Anderson allegedly died together. We set the record straight: Anderson was smuggled South, healed, married, and lived long. The myth endured because it offered symmetry the facts refused to give.The real ending took shape in steel and soil. When rails reached Wichita, the cattle trade moved on. Newton traded saloons for schoolhouses, brothels for church steeples, and six-shooters for threshing machines. Mennonite farmers arrived with turkey red wheat, barbed wire cinched the open range, and a new civic identity took root. Through it all, Riley remained a shadow—possibly consumed by illness, possibly drifting down the line—proof that the West wasn't just won in gun smoke, but manufactured in headlines and remade by commerce and community.If this story reframed how you think about the Wild West—where legend wrestles with ledger—tap follow, share with a history lover, and leave a review telling us which version of the story you believe.Support the showIf you'd like to buy one or more of our fully illustrated dime novel publications, you can click the link I've included.

Kyle Voth, and Tyler and Margaret Warkentin grew up in Mennonite anabaptist communities in North and South America. In this interview, they discuss with Michael Penfold the history, culture and beliefs of the Mennonites, and how growing up they had no peace that they were right with God or sure of getting to heaven. Watch their fascinating stories and learn where the assurance of salvation comes from. Recorded in Manitoba, Canada, 24th Feb 2026 Complete Series: We Were Raised Mennonite The post We Were Raised Mennonite But We Had No Peace With God | Kyle, Tyler & Margaret first appeared on Gospel Hall Audio.

AMISH Mennonite PA Dutch Stream- Legends, Secrets, Folklore, Witchcraft and MOREBecome a supporter of this podcast: https://www.spreaker.com/podcast/missing-persons-mysteries--5624803/support.

Submitting to government authorities, Mennonites, self justification from great evils and more on Called to Communion with Dr. David Anders.

Sometimes communion services in Mennonite churches can be a time of anxiety and bring up questions about assurance of salvation. Why is that? What is a proper way to think about and prepare for communion? Verlon Miller and Marlin Sommers explain how Mennonite churches traditionally have observed communion, and how we can come to the Lord's Supper with joy rather than fear.Anabaptists and the Sacraments: It's Complicated! - Dean TaylorThis is the 306th episode of Anabaptist Perspectives, a podcast, blog, and YouTube channel that examines various aspects of conservative Anabaptist life and thought.Sign-up for our monthly email newsletter which contains new and featured content!Join us on Patreon or become a website partner to enjoy bonus content!Visit our YouTube channel or connect on Facebook.Read essays from our blog or listen to them on our podcast, Essays for King JesusSubscribe on your podcast provider of choiceSupport us or learn more at anabaptistperspectives.org.The views expressed by our guests are solely their own and do not necessarily reflect the views of Anabaptist Perspectives or Wellspring Mennonite Church.

Religious Liberty: May the courts enjoin ICE from conducting raids in churches? - Argued: Thu, 05 Feb 2026 13:41:14 EDT

This week on the show we're joined by Mennonite pastor David C. L. Driedger to talk about his new book Nothing Will Save Us: A Theology of Immeasurable Life. We talk 2010s theology blogs, Canada, Thomas Muntzer, and how to deal with Christianity being so complicated.#Pre-order our bookhttps://themagnificast.wordpress.com/pre-order-now-enough-is-enough-degrowth-capitalism-and-liberation-theology/Get our Winstanley Zinehttps://themagnificast.wordpress.com/zines/Join our patreonhttp://patreon.com/themagnificastMusic by Amaryah Armstrong and theillalogicalspoon

Do you ever feel like life has become louder, faster, and more demanding than your heart was meant to carry? In this week’s episode of The Love Offering Podcast, I’m joined by counselor, author, and farm-living mama Brenda Yoder to talk about her new book, Uncomplicated: Simple Secrets for a Compelling Life. This conversation is a gentle invitation to slow down, breathe deep, and rediscover the wisdom that once shaped steady, grounded lives. Brenda draws from the practices of our grandmothers and the rhythms of Amish and Mennonite communities to share practical, life-giving lessons for today’s busy women. We talk about what it looks like to resist the pull of constant chaos and instead cultivate a calm presence, authentic faith, and a steady voice of reason—right where you are. In our conversation, you’ll hear: Why simpler doesn’t mean easier—but it often means better How timeless practices can bring peace to modern life What past generations can teach us about faith, work, family, and rest Small, practical shifts you can make to live with more intention No matter your season of life or where you call home, this episode offers encouragement and wisdom for anyone longing for a more grounded, meaningful way of living. You can listen to the episode now wherever you get your podcasts. I pray this conversation meets you right where you are and reminds you that a simpler life is still possible—and deeply compelling. Connect with Brenda: https://brendayoder.com/ Connect with Rachael: https://rachaelkadams.com/ Download your Free Love Always Devotional: https://rachaelkadams.com/free/Support the Show: https://rachaelkadams.com/ Discover more Christian podcasts at lifeaudio.com and inquire about advertising opportunities at lifeaudio.com/contact-us.

6 losers from the modern world decide to become Suddenly Amish! Can they handle the simple life? Or will they crash out and return to their creature comforts? Love the girls? Get more of their cringey, awesome content at Patreon.com/realitytvcringe!Follow us on IG https://instagram.com/realitytvcringeSubscribe to see our raccoon faces on YouTube! https://www.youtube.com/channel/UC_2CgqXLWjIEKV9PCtH3Kjw?sub_confirmation=1Leave a message for us on SpeakPipe: https://speakpipe.com/realitytvcringeSupport the pod by leaving a 5-star review on your favorite podcast platform! Thank you so much.