Podcasts about ghrh

Today, we're diving into an exciting peptide therapy called tesamorelin. You might have heard of it if you're interested in anti-aging treatments.  In this episode, we'll break down exactly what tesamorelin is, how it works in the body, and the potential benefits it can offer. Plus, we'll talk about the possible side effects and risks associated with the therapy, and how it compares to another popular peptide we discussed last week, sermorelin.  What is Tesamorelin? Tesamorelin is a synthetic peptide that acts as a growth hormone-releasing hormone (GHRH) analog. In simple terms, it stimulates the body's natural production of growth hormone (GH) by targeting the pituitary gland, which is responsible for releasing growth hormone.  Unlike direct growth hormone replacement therapy, where you inject synthetic growth hormone into your body, tesamorelin works by prompting your body to produce its own growth hormone naturally. This is often considered a more natural approach to restoring optimal hormone levels. Originally, tesamorelin was approved by the FDA to treat lipodystrophy (abnormal fat distribution) in HIV patients who were experiencing excess abdominal fat. However, its use has since expanded in the realm of anti-aging and fat loss due to its ability to promote fat metabolism, muscle development, and overall vitality. How Does Tesamorelin Work? In essence, tesamorelin taps into your body's natural ability to produce growth hormone, rather than injecting it directly. This is why it's often considered a safer, less invasive alternative to traditional growth hormone therapy. It's typically given once daily via subcutaneous injections (just under the skin). Depending on the health condition being treated, some individuals may need to dose less frequently. What's the Difference Between Tesamorelin and Sermorelin? While both tesamorelin and sermorelin are peptides that stimulate the release of growth hormone, they differ in their structure and the specific ways they interact with the body. Tesamorelin is a modified version of GHRH that specifically targets the release of growth hormone from the pituitary gland. It's particularly effective in reducing abdominal fat (especially visceral fat) and improving body composition, which makes it popular for individuals seeking fat loss and anti-aging benefits. Sermorelin, on the other hand, is a shorter form of GHRH and has a more general effect on growth hormone secretion. While it also stimulates the pituitary to release growth hormone, it is often used in younger individuals or those seeking overall growth hormone balance and anti-aging benefits rather than specifically targeting fat loss. Potential Benefits of Tesamorelin Therapy Fat Loss and Body Composition: One of the most well-known benefits of tesamorelin is its ability to reduce abdominal fat and improve overall body composition. It is especially effective at targeting visceral fat, the fat stored around internal organs. This can be beneficial for those looking to lose stubborn belly fat, which is linked to several health issues like heart disease, diabetes, high blood pressure, and fatty liver disease. Improved Muscle Mass: Since growth hormone plays a key role in muscle development, tesamorelin can help increase lean muscle mass and improve muscle tone. It's especially helpful for older adults or people recovering from injuries who want to retain or regain muscle strength. Increased Energy Levels: Higher levels of growth hormone can result in improved energy, vitality, and endurance. Many patients report feeling more energized throughout the day, which can improve quality of life and overall activity levels. Better Skin and Hair Health: Tesamorelin's effects on collagen production can contribute to improved skin tone, elasticity, and texture. It may also benefit hair health, making it a popular option for individuals seeking anti-aging benefits beyond just fat loss and muscle gain. Improved Metabolism: Tesamorelin may enhance the body's metabolism, aiding in better fat burning and more efficient use of nutrients, which can be beneficial for weight management. Cognitive Function: Some studies suggest that tesamorelin may have cognitive benefits, including improved memory and mental clarity, likely due to the overall boost in growth hormone levels. Potential Side Effects and Risks As with any therapy, tesamorelin comes with potential side effects and risks. While side effects are generally mild and well-tolerated, they can include: Injection site reactions: Pain, redness, or swelling at the injection site. Headaches: Some people report mild to moderate headaches, especially when first starting the therapy. Joint pain or muscle aches: Increased growth hormone levels can sometimes lead to discomfort in muscles or joints. Fluid retention: Some individuals may notice mild swelling or bloating, particularly in the hands or feet. Long-term use of growth hormone-stimulating therapies like tesamorelin may increase the risk of carpal tunnel syndrome, joint issues, or diabetes in predisposed individuals.  Although rare, there is a concern that stimulating growth hormone production could accelerate the growth of existing cancers, so it's important to have a thorough health evaluation before starting therapy. As always, consulting with a healthcare provider before starting tesamorelin therapy is essential, especially if you have a history of cancer, pituitary gland disorders, or chronic health conditions. Thanks for listening to The Peptide Podcast. If you found this episode helpful, be sure to subscribe and leave a review. And as always, have a happy, healthy week. If you're ready to dive deeper into the world of nutrition, don't miss my new ebook, Eat Smart: Powerful Tips for a Healthier You, now available on Amazon! It's packed with easy-to-understand, science-backed tips to help you optimize your diet, boost metabolism, and reduce inflammation. The best part? If you have Kindle Unlimited, it's always free! So grab your copy today and start your journey to a healthier, smarter way of eating!

Today, we're talking about sermorelin peptide therapy, an emerging peptide therapy option that's gaining attention for its potential benefits in anti-aging, muscle health, and overall vitality.  Whether you've heard about it before or are learning about it for the first time, this episode will break down exactly what sermorelin is, how it works, and why some people are turning to it for a boost in their health. Let's dive right in! What is Sermorelin? Sermorelin is a synthetic peptide that mimics the naturally occurring hormone growth hormone-releasing hormone (GHRH), which stimulates the pituitary gland to release growth hormone (GH). Growth hormone is important for various functions in the body, including growth during childhood, metabolism, muscle and bone health, and tissue repair. As we age, our natural production of growth hormone declines, which can contribute to symptoms like reduced muscle mass, increased body fat, lower energy levels, and other signs of aging. Sermorelin therapy is often used to boost the body's natural production of growth hormone, rather than injecting synthetic growth hormone directly. How Does Sermorelin Work? Unlike traditional growth hormone replacement therapies, where synthetic growth hormone is injected directly into the body, sermorelin therapy encourages your body to ramp up its own production of growth hormone. This is often seen as a more natural approach, with fewer potential risks associated with long-term synthetic growth hormone use. Typically, sermorelin is administered via subcutaneous injection (injected under the skin) given in the belly or upper thigh once a day or three to five times per week. The goal is to restore growth hormone levels to a more youthful range, improving overall health and well-being. Potential Benefits of Sermorelin Therapy So, what can sermorelin peptide therapy do for you? While results can vary, some of the potential benefits include: Improved Muscle Mass and Strength: Growth hormone plays a key role in muscle growth, and as sermorelin stimulates the pituitary to release more of it, many patients report an increase in muscle mass and strength over time. Fat Reduction: Sermorelin may help increase fat burning and promote lean muscle development, which can aid in weight loss and fat loss. Better Sleep Quality: Growth hormone is linked to deeper, more restful sleep. Many people undergoing sermorelin therapy notice an improvement in sleep patterns. Enhanced Energy Levels: With increased growth hormone production, some individuals experience a boost in energy, stamina, and overall vitality. Improved Skin Tone and Elasticity: Sermorelin may help stimulate the production of collagen, leading to firmer, more youthful-looking skin. Faster Recovery and Healing: Increased growth hormone levels can help with the repair of tissues and muscles, speeding up recovery from injuries or workouts. Better Mood and Mental Clarity: Some users report enhanced cognitive function, better mood, and a clearer mind, likely due to the overall improvement in physical health and hormone balance. Potential Side Effects and Risks As with any treatment, sermorelin peptide therapy comes with its own set of potential side effects and risks. Most people tolerate the therapy well, but some may experience mild side effects, such as: Injection site reactions: Redness, swelling, or irritation at the site of injection. Headaches: Some people report headaches, particularly when starting therapy. Flushing or dizziness: A warm, flushed feeling or dizziness may occur, though it's typically short-lived. Joint or muscle pain: Occasionally, users may experience discomfort in muscles or joints, especially in the early stages of therapy. Water retention: Some people might notice mild swelling or water retention. In rare cases, there can be more serious side effects, such as excessive growth hormone levels, which could lead to conditions like carpal tunnel syndrome, diabetes, and  joint enlargement. It's important to have regular check-ups with a healthcare provider to monitor any side effects and ensure the treatment is working as intended. Additionally, since sermorelin stimulates the body's natural production of growth hormone, it's important for individuals to be screened for underlying medical conditions such as pituitary gland issues or active cancer, as these could be aggravated by the therapy. If you're interested in exploring sermorelin therapy, talk to a healthcare professional who specializes in hormone replacement or peptide therapies to see if it's right for you. Thanks for listening to The Peptide Podcast. If you found this episode helpful, be sure to subscribe and leave a review. And as always, have a happy, healthy week. If you're ready to dive deeper into the world of nutrition, don't miss my new ebook, Eat Smart: Powerful Tips for a Healthier You, now available on Amazon! It's packed with easy-to-understand, science-backed tips to help you optimize your diet, boost metabolism, and reduce inflammation. The best part? If you have Kindle Unlimited, it's always free! So grab your copy today and start your journey to a healthier, smarter way of eating!

Fitness, Health, and Lifestyle Titan Medical CEO and Owner John Tsikouris talks about the benefits of GLP-1s! How it can affect lean muscle and weight loss. John answers questions from our live stream followers regarding hormones replacement therapy, muscle gains, blood work and gym advice!

Titan Medical Owner and CEO John Tsikouris goes live from our offices in Tampa, Florida! He Discusses the benefits of our new Titan Takeover bundle which is GLP-1 and Tesamorelin. Titan Medical can help you feel better and look better with these therapies. Have a question? Join us live!

In dieser 2. Episode zum Thema Schlaf dreht sich alles um körperliche Leistungsfähigkeit, Muskelaufbau und Fettreduktion. Denn was hat das alles mit Schlaf zu tun? Cortisol Supression Agent (CSA): https://www.big-zone.de/Big-Zone-C.S.A.-60-Kapseln/3372 -10% Rabatt mit dem Code "Larry10" Studienauszug: The somatropic axis and sleep, 2001. Ghrelin alone or co-administered with GHRH or CRH increases non-REM sleep and decreases REM sleep in young males, 2008

7/19: Titan Lifestyle! -Live Q&A with Titan Medical Athlete Big Dru Therapy of Week: Tesamorelin This FDA approved therapy is very similar to IGF-1 and MK 677. Tesamorelin is a synthetic form of GHRH. Titan Medical Center athlete and bodybuilder Big Dru, talks about Peptides, Titan Medical Center therapy Hercules Potion, Hormone Replacement Therapies, and much more! Have a question? Join us live every Friday at 2PM EST.

Fitness, Health, and Lifestyle Therapy of Week: Tesamorelin This FDA approved therapy is very similar to IGF-1 and MK 677. Tesamorelin is a synthetic form of GHRH. BENEFITS: * Weight-loss * Targets Belly Fat * Helps Increase Energy Levels * Increases IGF-1 Levels * Improves Lean Muscle * May Help Increase Strength * May Help Muscle Density * Helps Promote Anti- Aging Owner and CEO of Titan Medical Center, John Tsikouris gives an insight on targeting visceral belly fat with Tesamorelin. He also touches on the topics of today: Psychedelics could treat some of the worst chronic pain in the world and Blood proteins predict cancer risk seven years in advance. Have a question? Join us live!

Upon diagnosing acute myeloid leukemia (AML), the initial step involves assessing a patient's eligibility for intensive chemotherapy. The standard treatment protocol for newly diagnosed AML encompasses intensive chemotherapy to achieve complete remission, followed by post-remission therapy, which may include additional chemotherapy and/or stem cell transplantation. Complete response rates to this approach range from 60% to 85% in adults aged 60 or younger. While this approach has proven effective, the risk of relapse within three years of diagnosis remains a significant concern. Numerous factors contribute to the likelihood of relapse, including short duration of remission, genetic derangements, prior allogeneic transplantation, advanced age, and concomitant comorbidities. These negative prognostic factors underscore the need for continuous exploration of novel therapeutic agents, as relapse remains a formidable barrier to treatment success. In a new study, researchers Simonetta I. Gaumond, Rama Abdin, Joel Costoya, Andrew V. Schally (awarded the Nobel Prize in Physiology or Medicine in 1977), and Joaquin J. Jimenez from the University of Miami, Florida Atlantic University and Veterans Affairs Medical Center, Miami, investigated newly emerging therapies targeting drug resistance in AML. On April 8, 2024, their new research paper was published in Oncotarget's Volume 15, entitled, “Exploring the role of GHRH antagonist MIA-602 in overcoming Doxorubicin-resistance in acute myeloid leukemia.” Full blog - https://www.oncotarget.org/2024/05/23/combating-doxorubicin-resistant-acute-myeloid-leukemia/ Paper DOI - https://doi.org/10.18632/oncotarget.28579 Correspondence to - Simonetta I. Gaumond - sxg1204@miami.edu Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28579 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, leukemia, AML, resistance, growth hormone-releasing hormone, MIA-602 About Oncotarget Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. Oncotarget is indexed and archived by PubMed/Medline, PubMed Central, Scopus, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science). To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

BUFFALO, NY- April 10, 2024 – A new #researchpaper was #published in Oncotarget's Volume 15 on April 8, 2024, entitled, “Exploring the role of GHRH antagonist MIA-602 in overcoming Doxorubicin-resistance in acute myeloid leukemia.” Acute myeloid leukemia (AML) is characterized by the rapid proliferation of mutagenic hematopoietic progenitors in the bone marrow. Conventional therapies include chemotherapy and bone marrow stem cell transplantation; however, they are often associated with poor prognosis. Notably, growth hormone-releasing hormone (GHRH) receptor antagonist MIA-602 has been shown to impede the growth of various human cancer cell lines, including AML. In this new study, researchers Simonetta I. Gaumond, Rama Abdin, Joel Costoya, Andrew V. Schally, and Joaquin J. Jimenez from the University of Miami, Florida Atlantic University and Veterans Affairs Medical Center, Miami examined the impact of MIA-602 as monotherapy and in combination with Doxorubicin on three Doxorubicin-resistant AML cell lines, KG-1A, U-937, and K-562. “Given the role of GHRH in multiple cancer types, it is possible that GHRH antagonists may offer an alternative treatment approach for AML as well as drug-resistant AML, which may circumvent the side effects associated with standard chemotherapy.” The in vitro results revealed a significant reduction in cell viability for all treated wild-type cells. Doxorubicin-resistant clones were similarly susceptible to MIA-602 as the wild-type counterpart. Their in vivo experiment of xenografted nude mice with Doxorubicin-resistant K-562 revealed a reduction in tumor volume with MIA-602 treatment compared to control. “Our study demonstrates that these three AML cell lines, and their Doxorubicin-resistant clones, are susceptible to GHRH antagonist MIA-602.” DOI - https://doi.org/10.18632/oncotarget.28579 Correspondence to - Simonetta I. Gaumond - sxg1204@miami.edu Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, leukemia, AML, resistance, growth hormone-releasing hormone, MIA-602 About Oncotarget Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. Oncotarget is indexed and archived by PubMed/Medline, PubMed Central, Scopus, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science). To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957

Noradrenaline (norepinephrine) is a neurotransmitter and hormone that plays a role in the body's "fight or flight" response.  Acetylcholine is a neurotransmitter (“brain” +” across” + “to send”) that helps transmit signals in the brain and body. Its name comes from its chemical structure, an acetate group and a choline molecule.  Dopamine is a neurotransmitter that plays a role in motivation, reward, and movement. Its name comes from its chemical structure, a combination of two molecules called dihydroxyphenylalanine and dopamine. Adrenaline (epinephrine) is a hormone and neurotransmitter that helps the body respond to stress. Its name comes from its source, the adrenal glands.  Serotonin is a neurotransmitter that is involved in mood, appetite, and sleep. Its name comes from its chemical structure, a combination of sero- (meaning "serum") and -tonin (meaning "tonic" or "substance that modifies").  Corticotropin-releasing hormone (CRH) is a hormone that stimulates the release of cortisol, a stress hormone. The name comes from its function of stimulating the release of corticotropin, a hormone that stimulates the adrenal glands. Also, it gets its name from its role in stimulating the release of adrenocorticotropic hormone (ACTH) from the pituitary gland, which in turn stimulates the release of cortisol from the adrenal gland. Vasopressin is a hormone that regulates water balance in the body. Its name comes from its ability to constrict blood vessels (vasoconstriction) and increase blood pressure. Vasopressin, also known as antidiuretic hormone (ADH), is so named because it regulates water balance by causing the kidneys to reabsorb water. Thyrotropin-releasing hormone (TRH) is a hormone that stimulates the release of thyroid-stimulating hormone (TSH), which regulates the thyroid gland. Its name comes from its function of stimulating the release of thyrotropin.  Oxytocin is a hormone that is involved in social bonding, childbirth, and lactation. Its name comes from its ability to stimulate uterine contractions (oxytocic) and milk ejection (lactogenic).  Gonadotropin-releasing hormone (GnRH) is a hormone that stimulates the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which regulate the reproductive system. Its name comes from its function of stimulating the release of gonadotropins.  Growth hormone–releasing hormone (GHRH) is a hormone that stimulates the release of growth hormone (GH), which regulates growth and metabolism. Its name comes from its function of stimulating the release of growth hormone.  Catecholamines are a group of hormones and neurotransmitters that includes adrenaline, noradrenaline, and dopamine. Their name comes from their chemical structure, which includes a catechol group and an amine group.  Histamine is a neurotransmitter and hormone that is involved in inflammation, allergies, and gastric acid secretion. ACTH (adrenocorticotropic hormone) is a hormone that stimulates the release of cortisol from the adrenal glands.  Orexin (hypocretin) is a neurotransmitter that is involved in wakefulness and appetite. Its name comes from its discovery in the hypothalamus and its ability to stimulate food intake (orexigenic).  Glutamic acid (glutamate) is a neurotransmitter that is involved in learning, memory, and neural plasticity. Its name comes from its chemical structure, a combination of glutamine and an acid group.  Galanin is a neuropeptide that is involved in pain perception, mood, and appetite. Its name comes from its discovery in the galanin-containing neurons of the hypothalamus.  Neurotensin comes from the words "neuro," meaning related to nerves, and "tensin," which refers to its ability to cause contraction in smooth muscle. Neurotensin is a neuropeptide that is found in the central nervous system and gastrointestinal tract. --- Support this podcast: https://podcasters.spotify.com/pod/show/liam-connerly/support

Heart failure with preserved ejection fraction (HFpEF) is, in many ways, a fascinating tale of modern cardiovascular medicine that, according to lead author Dr. Joshua Hare (University of Miami Miller School of Medicine), has taught cardiovascular researchers and clinicians a lot of humility. Understanding HFpEF in a variety of animal models has led to a paradigm shift away from heart failure linked to low ejection fraction. In this episode Associate Editor Dr. Jonathan Kirk (Loyola University Chicago Stritch School of Medicine) interviews Dr. Hare along with expert Dr. Julie McMullen (Baker Heart and Diabetes Institute, Melbourne, Australia) about the latest study by Kanashiro-Takeuchi et al. The Hare Lab was originally attracted to a cardiometabolic model of HFpEF pioneered by Dr. Joseph Hill, because in a large proportion of human patients, HFpEF is due to metabolic syndrome, which is a combination of obesity, diabetes, and hypertension. Armed with the ability to create this cardiometabolic HFpEF model, Hare and co-authors decided to test growth hormone-releasing hormone-agonist using a powerhouse of methods to determine if exercise intolerance could be improved. Kanashiro-Takeuchi et al. found that diastolic function and exercise performance improved, and myocyte hypertrophy and fibrosis were restored. Essentially all of the features of cardiometabolic HFpEF responded to treatment with GHRH-agonist. The authors did not see a reduction in blood pressure or weight, indicating a direct myocardial effect. In a wide-ranging discussion that touches on skeletal muscle, aging, sarcomeric proteins, and the technical complexities of running titin gels and PV loops, our experts explain why HFpEF is such a challenging syndrome to treat and why this translational research is so important. Listen now.   Rosemeire M. Kanashiro-Takeuchi, Lauro M. Takeuchi, Raul A. Dulce, Katarzyna Kazmierczak, Wayne Balkan, Renzhi Cai, Wei Sha, Andrew V. Schally, Joshua M. Hare Efficacy of a Growth Hormone-Releasing Hormone Agonist in a Murine Model of Cardiometabolic Heart Failure with Preserved Ejection Fraction Am J Physiol Heart Circ Physiol, published April 25, 2023. DOI: 10.1152/ajpheart.00601.2022.

Your hosts Stevesmi and Da Mobster discuss Peptides for iTunes with this one being Sermorelin (GRF 1-29) doses, cycles, benefits and its side effects • Just what is Sermorelin and why would you pick this over another peptide • Why you need a GHRP with a GHRH like Sermorelin to get the best from it. • Its crazy short half life of just 10 minutes • We debate both benefits and side effects • How to optimize the timing of an injection around the gym and sleep • How you have the best access to information in history right now • Why an anti-ageing peptide is useful • Suggested dosing • As always we talk about how to prepare and store it as well as where best to inject it. Link to article: https://www.evolutionary.org/sermorelin-GRF-1-29-peptide Links to Evo threads: 1. https://www.evolutionary.org/forums/anabolic-steroids-peds/got-simple-sermorelin-question-46980.html 2. https://www.evolutionary.org/forums/anabolic-steroids-peds/sermorelin-bodybuilding-48495.html 3. https://www.evolutionary.org/forums/anabolic-steroids-peds/best-cardarine-sermorelin-get-where-get-them-65874.html 4. https://www.evolutionary.org/forums/anabolic-steroids-peds/ghrp-2-a-5671.html 5. https://www.evolutionary.org/forums/anabolic-steroids-peds/expired-hgh-11898-2.html For 1-on-1 coaching/consultation/source help requests hit up Stevesmi https://www.elitefitness.com/forum/members/stevesmi.html https://www.evolutionary.org/forums/members/stevesmi.html Where to get blood tests: https://www.evolutionary.org/forums/source-talk/bloodwork-private-md-5695.html Please note we're not doctors and the opinions are ours. It's our view and is based on our experience and views on the topic. Our Podcasts are for informational purposes and entertainment only. The Freedom of speech and 1st amendment applies.

Today we are talking about CJC 1295 and its potential benefits. All this and more in less than 2 minutes.  An excellent example of the ability peptides have to work together with our own bodies comes from a few of the most commonly used peptides available for anti-aging: growth hormone-releasing hormones (or GHRHs) and growth hormone-releasing peptides (GHRPs).  As you know, aging is essentially our bodies breaking down at the cellular level. As we age, we deal with things like decreased muscle mass, decreased immune function, a decreased sex drive, increased skin issues, change in mood, the list goes on and on.  All of this along with depression, and many more unwanted effects seem to inevitably come as part of the aging process. Some of this dysfunction can be treated with GHRH peptides like CJC-1295 or GHRP peptides like Ipamorelin or a combination of BOTH! Today we are going to focus on CJC 1295. What is CJC 1295? CJC 1295 is a lab-made peptide hormone, primarily functioning as a GHRH or amplifier. In simple terms, the peptide increases protein synthesis, human growth hormone (aka HGH) secretion, and insulin-like growth factor (or IGF-1).  IGF-1 is a hormone that's similar in molecular structure to insulin and plays an important role in childhood growth and has anabolic effects (or muscle-building effects) in adults.  What are the BENEFITS?  CJC 1295 is useful to those looking to increase lean muscle mass and strength by stimulating the release of growth hormone. It also promotes muscle recovery as it boosts protein synthesis levels and helps the growth of muscle tissues resulting in quicker recovery times for athletes and those with injuries. And because it stimulates the production of IGF-1, it can help decrease body fat and increase natural strength. Compared to other peptide therapies, CJC 1295 has a longer half-life of 30 minutes which requires fewer peptide injections and results in the continual release of growth hormone.  It also has minimal effect on cortisol levels. Cortisol is a hormone that's released into your bloodstream when your body undergoes stress. This hormone causes an increase in your heart rate and blood pressure. It's your natural “fight or flight” response. However, over time, if your body experiences repeated stress, you may begin to feel tired, irritable, depressed, and even experience weight gain.   BUT DOES IT WORK? Peptide therapies are not miracles in a bottle. They don't guarantee desired results. Like anything in life, you must also make lifestyle changes when it comes to certain desired outcomes. For example, a poor diet and lack of exercise can have a negative impact on your health and cause weight gain, joint pain, and can even lead to type 2 diabetes. Peptide therapy in addition to healthy lifestyle choices can help you achieve your health goals! Possible side effects include redness or itching at the injection site. You should tell your healthcare provider about any side effects you think you may be experiencing.  You can find more information at pepties.com.  That's peptides without the D. Where we are tying all the peptide information together in one easy place. Thanks again for listening to The Peptide Podcast, we love having you as part of our community. If you love this podcast please share it with your friends and family on social media. And subscribe to our podcast. Have a happy, healthy week!

Welcome to CHS(Clinical Hormone Studies) Episode 3, where we attempt to break down some of the world's most bizarre cases of hormones gone absolutely wrong. I'm your host, Suraj Oruganti, and today we will be talking about GHRH, a hormone that is in charge of releasing the growth hormone. We will be going over how GHRH works in the body when functioning properly, what happens when GHRH starts to go awry, and some case studies of how these problems were fixed.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.17.254862v1?rss=1 Authors: Lima, J., Debarba, L. K., Khan, M., Ubah, C., didyuk, o., Ayyar, I., Koch, M., Sadagurski, M. Abstract: Growth hormone (GH) receptor (GHR), expressed in different brain regions, is known to participate in the regulation of whole-body energy homeostasis and glucose metabolism. However, GH activation of these GHR-expressing neurons is less studied. We have generated a novel GHR-driven Cre recombinase transgenic mouse line (GHR cre) in combination with the floxed tdTomato reporter mouse line we tracked and activated GHR-expressing neurons in different regions of the brain. We focused on neurons of the hypothalamic arcuate nucleus (ARC) where GHR was shown to elicit a negative feedback loop that regulates GH production. We found that ARC GHR+ neurons are co-localized with AgRP, GHRH, and somatostatin neurons, which were activated by GH stimulation. Using designer receptors exclusively activated by designer drugs (DREADDs) to control GHR-ARC neuronal activity, we revealed that activation of GHR-ARC neurons was sufficient in regulating distinct aspects of energy balance and glucose metabolism. Overall, our study provides a novel mouse model to study in vivo regulation and physiological function of GHR-expressing neurons in various brain regions. Furthermore, we identified for the first time specific neuronal population that responds to GH and directly linked it to metabolic responses in vivo. Copy rights belong to original authors. Visit the link for more info

bengreenfieldfitness.com/416     News Flashes –  for more…5:00           [5:40] Those who want to lose weight but don’t want to give up their beer will find this study quite compelling: alcohol (especially beer) seems to be OK if you’re doing HIIT training:          [9:05] Alcohol consumption following a workout doesn’t seem to affect the majority of the biological and physical benefits, but cortisol increased, and testosterone and muscle protein synthesis decreased, so long term muscular adaptations could be impaired if alcohol consumption during recovery is consistent: (Alcohol is a well known HGH acting at the GHRH level inhibitor/supressor and it also leads to IGF-1 decrease. Surprising it's not mentioned in the study.)              [13:00] Chalk another one up to the life-extending benefits of low-to-moderate alcohol consumption, at least in         [20:45] Israeli firm says  (500mcg!) with no high           [23:45] An interesting idea: Use your old coffee grounds by drying them, mixing into foods, and then burn more fat by changing your gut biome?         Listener Q&A:     How To Reverse Gray Hair...36:34       The Adrenal Fatigue Myth...55:30       How To Recover From COVID-19...1:07:35     Episode sponsors: Kion Coffee, Organifi, Seed Daily Synbiotic, Paleo Valley   bengreenfieldfitness.com/416

In an attempt to recover from the last episode’s derailment by boy bands, Ruka speeds through an overview of the hypothalamus and the anterior pituitary. In the process, she discovers Libby’s deep past with the movie Cool Runnings. Key Words - New record: 46! adrenal cortex, adrenaline, adrenocorticotropic hormone (ACTH), anterior pituitary, biogenic amine, catecholamine, corticotropin, corticotropin-releasing hormone (CRH), dopamine, endocrine feedback loop, epinephrine, estradiol, follicle-stimulating hormone (FSH), germ cell, gonadotropin-releasing hormone (GnRH), gonadotropins, gonads, growth hormone (GH), growth hormone release inhibiting hormone (GHRIH), growth hormone-releasing hormone (GHRH), homeostasis, hypothalamo-pituitary-adrenal (HPA) axis, hypothalamo-pituitary-gonadal (HPG) axis, infundibulum, insulin-like growth factor 1 (IGF-1), luteinizing hormone (LH), median eminence, melanocyte, melanocyte-stimulating hormone (MSH), melanocyte-stimulating hormone release-inhibiting factor (MIF), melanocyte-stimulating hormone-releasing factor (MRF), ovaries, ovum, parvocellular neurons, peptide hormone, portal vasculature, progesterone, prolactin, somatostatin, sperm, testes, testosterone, thyroid-stimulating hormone (TSH), thyrotropin-releasing hormone (TRH), thyroxine, triiodothyronine Old West Word of the Day (Gap Junction Almanac) Oof Related Episode Episode 14: Turkey Saddle [Hypothalamus and Posterior Pituitary] References and Resources Textbooks Vander’s Human Physiology, 13th Edition Principles of Neural Science, Kandel, Schwartz, and Jessell, 4th Edition Fundamental Neuroscience for Basic and Clinical Applications, Haines, 3rd Edition   Connect with us! FB @HeadshakeShow T @HeadshakeShow ‘Sta @HeadshakeNinja Site headshake.show OR headshake.ninja   Music Bushwick Tarantella by Kevin MacLeod is licensed under a Creative Commons Attribution license (https://creativecommons.org/licenses/by/4.0/) Source: http://incompetech.com/music/royalty-free/index.html?isrc=USUAN1300002 Artist: http://incompetech.com/ Modified from original with volume fading and cuts   Disclaimer This podcast is for entertainment and education only. Neither of the hosts is a medical doctor, and nothing they say is medical advice. Please consult with your physician before making decisions about your health.

Dr. Michael Moeller, NMD is a gentleman, a doctor, and a scholar of optimizing men's health. He is a naturopathic physician who is the founder of Infinity Medicine and Wellness in Laguna Hills, California. He specializes in peripheral neuropathy regeneration, men's hormones, and men's health.  Today on the podcast we talk about growth hormone releasing peptides, growth hormone releasing hormones, and immunity. These peptides govern optimizing lean mass and muscle gains, sleep, immune health, and stimulate your body's recovery.  Here are a few of the peptides we speak about: Growth hormone releasing peptides Ipamorelin MK677  Ibutamoren GHRH - Growth Hormone Releasing Hormone Sermorelin Tesamorelin CJC 1295 Body Protecting Compound  BPC 157 Immune peptides Thymosin Beta 4 (TB-500) Thymosin Alpha 1 (TA-1) Sexual enhancement Bremelanotide - PT 141  I hope you guys enjoy today's episode! Jump on Youtube and check out more video with Dr. Michael Moeller (Dr. Moe) today.  Links:  Dr. Moeller's website  I   https://www.drmichaelmoeller.com/ Four peptides for immune function I Dr. Michael Moeller NMD Dr. Moeller's prolific YouTube channel Dr. Raisanen's healing with peptides - blog post  Dr. Raisanen's TRT article

See all the Healthcast at https://www.biobalancehealth.com/healthcast-blog/ The brain is complex and is not a static organ. It is always growing new cells and breaking down the old cells. Like the rest of the body the brain is in a state of flux all the time. As we age without our sex hormones and growth hormones, breaking down occurs more rapidly than regrowth and our brain literally shrinks Another quite rapid symptom is the loss of short -term memory at the time before menopause when testosterone and GH decrease to a critical level. These hormone losses trigger the diverting of the brain blood flow from the area of the brain that holds recent memories. This causes immediate loss of words you are looking for when trying to describe something or someone. Most people forget names of people and places. There is loss of special ability like the function you need to discern the length or size of something or interpret architectural plans. This immediate memory loss reverses in the first 6 months of testosterone replacement, if it is within the first 10 years after testosterone levels drop. “An Italian study in 2000 demonstrated that there is a cognitive impairment without dementia which increases with age and is more prevalent in women than men” “In the same year, Dr. Capurso and researchers at the university of Bari found an age -related decline in cognitive function that causes a mild deterioration in memory performance, executive functioning and speed of cognitive processing” “The study concludes that the aging associated cognitive decline may be preventable and suggest the following: Avoidance of cardiovascular and other chronic diseases Attaining a high -level education Maintenance of vision and hearing capacities. Dr. Maupin believes that brain function can be protected from decline by taking testosterone, estradiol (for women), keeping thyroid function and growth hormones optimal. Several studies reveal the truth that replacement of testosterone in the first 10 years after its decline, can delay the onset of Alzheimer's disease and dementia for 10 years after it would normally occur. Other studies on women showed that replacement of estradiol in any form delayed the onset of these diseases of aging brain by 10 more years if it is taken in the window of 10 years after menopause. This reveals how important the sex hormones are to our brains. We also want to talk about muscle mass, strength, and stamina and aging. The amount of muscle mass you maintain depends on how much testosterone and growth hormone you produce or replace, the amount and kind of exercise you do, the genetic composition of your muscle such as do you have 100% slow twitch muscle which gives you the ability for long distance and long lasting strenuous exercise, or 100% fast twitch muscle which makes you good at short spurts of muscle work, lifting weights, and short but powerful muscle work of any kind or were you born with a combo? Diet/Nutrition is also important because you can -not build muscle without the building blocks from animal protein. When you are given replacement hormone of testosterone, it stimulates your production of growth hormone which you make naturally. This is important because age related reduction in growth hormone is one of the most robust endocrine markers of biological aging. The reduction of GH and IGF-1 impairs reference memory and seems to be reversable with the administration of GHRH. (growth hormone releasing hormones). “muscle strength is a critical component of the ability to walk and to avoid falls and fractures. Reduced muscle strength as we age is a major cause for an increased prevalence of disability. If we can prevent the loss of muscle as we age, we will age more slowly and remain independent as we grow older. Advancing adult age is associated with profound changes in body composition, the principal component of which is a decrease in skeletal muscle This age-related loss of skeletal muscle is referred to as sarcopenia.” “Studies indicate that age related decline in skeletal muscle may contribute to such age associated changes as reduction in bone density, insulin sensitivity, and aerobic capacity.” The final component of this week's conversation references the sensory system. The principal conclusion of the discussion regarding the loss of sense of taste and smell, hearing and sight, suggests that attending to: Nutrition Hormones Lifestyle May expand your lifespan, while, at the same time, enhance the quality of that human life.

12/3/19: On today’s Titan Talk (broadcast live at 6pm on Facebook, Instagram & Youtube!) Titan Medical Center CEO John Tsikouris goes over: Therapy of the week: CJC 1295 with Ipamorelin -GHRH: growth hormone releasing hormone -GHRP: growth hormone releasing peptide What are the benefits of these things? What do they do? Any negative side effects? -EDC endocrine disrupting chemicals (plastic) BPA -Micro plastics -Upcoming events: Kenzilla’s Lift for Gifts! BIG TITAN NEWS: -The Titan Program App -New location is almost done then it’s Grand Opening date/time! -Our new show on ABC in Florida from Sarasota to Crystal River. Tune in Sunday’s 11 AM soon! -Titan gear giveaway #titangear -Titan Weekly Newsletter Code Word Giveaway! Go to our 12/2/19 TITAN Weekly Newsletter: CJC 1295 with Ipamorelin! Events & Updates! (DIRECT Email Link https://conta.cc/2qWJaK8) & pick the code word John gives during this live to win FREE Titan Clothing gear! Choices are: Mandalorian, Injectables & Winter. Follow us on our social media, YouTube, & listen to us on our Titan Medical podcast! Don’t forget to join us on Friday when we go live with Titan Athlete Big Dru at 2pm! titanmedical #medicalscience #health #advice #tampa #therapy #medicalclinic #johntsikouris #medicalproviders #medicaladvice #ipamorelin #cjc1295 Titan Medical Center CEO John Tsikouris goes live on his Instagram and Facebook video feeds every Tuesday at 6pm (Titan Talk Tuesdays) and talks to his viewers and answers questions about health, fitness and medical science. We air the episodes here as soon as they're finished for your listening convenience.

Ghrelin ist der natürliche Ligand des wachstumshormon-sekretagogen (GHS)-Rezeptors (Kojima, 1999). Es stimuliert die Wachstumshormon (GH)-Ausschüttung an der Hypophyse und wirkt appetitsteigernd. Bisherige schlafendokrinologische Untersuchungen zeigen, dass die Hormone wachstumshormon-freisetzendes-Hormon (GHRH), Somatostatin, corticotropin-freisetzendes Hormon (CRH) und Cortisol in die Schlafregulation involviert sind. Auch synthetische Wachstumshormon-Sekretagoge (GHS) modulieren beim Menschen den Schlaf und beeinflussen die nächtliche hormonellen Sekretion. Ziel dieser Arbeit war es, die Effekte von Ghrelin auf das Schlaf-EEG und die nächtliche Hormonsekretion von GH, ACTH, Cortisol, Prolaktin und Leptin bei jungen gesunden Männern zu untersuchen. Nach Gabe von 4 x 50 µg Ghrelin iv. zu Beginn der Nacht fand sich ein signifikanter Anstieg des Tiefschlafs im Schlaf-EEG und der assoziierten nächtlichen GH-, Cortisol- und Prolaktin-Sekretion. Die Leptinspiegel waren nicht signifikant verändert. Diese Arbeit konnte zeigen, dass exogen appliziertes Ghrelin signifikante Wirkungen auf den humanen Schlaf und die schlafassoziierte Hormonsekretion ausübt. Anhand der Ergebnisse ist davon auszugehen, dass Ghrelin nicht nur auf die GH-Sekretion, das Appetitverhalten oder das Gewicht Einfluss nehmen kann, sondern eigene endogen-schlafmodulierende Effekte ausübt und bei jungen gesunden Männern als tiefschlaffördernder Faktor angesehen werden kann. Weiterhin bewirkt Ghrelin einen deutlichen Effekt auf die somatotrophe und corticotrophe Hormonsekretion, indem es die physiologischen Sekretionsmuster von GH und Cortisol stimuliert und intensiviert. Bei Betrachtung der gegensätzlichen Wirkungen der einzelnen Hormone GHRH und CRH auf den Schlaf ist dabei bemerkenswert, dass Ghrelin die GH-sekretagogen und tiefschlaffördernden Effekte von GHRH und die Cortisol-sekretagogen Effekte von CRH vereint. Man kann postulieren, dass Ghrelin eine mögliche Schnittstelle des somatotrophen und des corticotrophen Systems darstellt.

Repeated injection of GHRH leads to a decrease in the GH response in normal subjects. Arginine (Arg) stimulates GH secretion by suppression of hypothalamic somatostatin. To confirm these findings, eight normal men were examined in a series of five settings: test 1 (GHRH/GHRH-TRH), 100 micrograms GHRH injected iv, followed by 100 micrograms GHRH, iv, after 120 min and 200 micrograms TRH, iv, after 150 min; test 2 (GHRH/Arg-TRH), like test 1, but instead of the second GHRH injection, a 30 g Arg infusion over 30 min; test 3 (GHRH/GHRH-Arg-TRH), like test 1, but additionally a 30 g Arg infusion after 120 min; test 4 (GHRH-Arg-TRH), iv GHRH and Arg infusion initially, followed by iv TRH after 30 min; and test 5 (TRH), 200 micrograms TRH, iv, at 0 min. For statistical evaluation, the area under the GH curve (AUC) from 0-120 min was compared with the AUC from 120-240 min. The GH response to the second administration of GHRH was significantly lower (P < 0.02) than the first increase [AUC, 0.5 +/- 0.01 min.mg/L (mean +/- SE) vs. 1.2 +/- 0.3]. No significant differences were found between the GH responses to either GHRH or Arg alone (AUC, 0.9 +/- 0.2 min.mg/L vs. 0.9 +/- 0.2). A larger GH increase (P < 0.02) was seen after GHRH-Arg compared to GHRH alone (AUC, 1.9 +/- 0.4 min.mg/L vs. 1.2 +/- 0.3). The GH response (P < 0.02) to GHRH-Arg stimulation was lower after previous GHRH injection than after GHRH-Arg stimulation alone (AUC, 1.9 +/- 0.4 min.mg/L vs. 3.5 +/- 0.9). There was a statistically significant difference between the TRH-stimulated TSH response in test 4 compared to that in test 5. We could show that decreasing GH responses to repeated GHRH can be avoided by a combined stimulation with GHRH/Arg. These findings suggest that the decreased GH response to a second GHRH bolus may be partly due to an elevated hypothalamic somatostatin secretion, which can be suppressed by Arg. The lower GH response to GHRH-Arg stimulation after a previous GHRH bolus suggests, furthermore, that the readily available GH pool in the human pituitary may be limited.

The synthetic hexapeptide GH-releasing peptide (GHRP; His-D-Trp-Ala-Trp-D-Phe-Lys-NH2) specifically stimulates GH secretion in humans in vivo and in animals in vitro and in vivo via a still unknown receptor and mechanism. To determine the effect of GHRP on human somatotroph cells in vitro, we stimulated cell cultures derived from 12 different human somatotroph adenomas with GHRP alone and in combination with GH-releasing hormone (GHRH), TRH, and the somatostatin analog octreotide. GH secretion of all 12 adenoma cultures could be stimulated with GHRP, whereas GHRH was active only in 6 adenoma cultures. In GHRH-responsive cell cultures, simultaneous application of GHRH and GHRP had an additive effect on GH secretion. TRH stimulated GH release in 4 of 7 adenoma cultures; in TRH-responsive cell cultures there was also an additive effect of GHRP and TRH on GH secretion. In 5 of 9 adenoma cultures investigated, octreotide inhibited basal GH secretion. In these cell cultures, GHRP-induced GH release was suppressed by octreotide. In 5 of 5 cases, the protein kinase-C inhibitor phloretin partly inhibited GHRP-stimulated GH release, but not basal GH secretion. In summary, GH secretion was stimulated by GHRP in all somatotroph adenomas investigated, indicating that its unknown receptor and signaling pathway are expressed more consistently in somatotroph adenoma cells than those for GHRH, TRH, and somatostatin. Our data give further evidence that GHRP-stimulated GH secretion is mediated by a receptor different from that for GHRH or TRH, respectively, and that protein kinase-C is involved in the signal transduction pathway. Because human somatotroph adenoma cell cultures respond differently to various neuropeptides (GHRH, TRH, somatostatin, and others), they provide a model for further investigation of the mechanism of action of GHRP-induced GH secretion.