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Today we're talking about one of my favorite tools in functional and regenerative medicine, peptides. It's also quite the buzzword these days, but in this episode we're going deeper to explore how you can best stack them for your desired outcomes. You can think of peptide stacks as powerful curated treatment plans (without all the side effects you want to avoid!). When I first heard of peptides, I was so intrigued that I couldn't wait to experiment with them. In fact, I ordered thousands of dollars worth. I recently put together my own stack for surgery and recovery preparation. But there are many different outcomes you can stack for, including reducing inflammation, gut healing, anti-aging and longevity, and more. Peptides are just chains of amino acids that naturally occur. One powerful peptide is BPC-157, which is incredible for healing and nerve regeneration. When injected close to the site of an injury, it can help with all types of tissue and ligament damage. Thymosin alpha 1 is one of the most exciting peptides for immune dysfunction. It helps the immune system differentiate between friend and foe. Some peptides are better injected, but many can also be taken orally. GHK-copper can be used a few different ways, for instance, taken orally or used topically. It boosts collagen and reduces oxidative stress. Epitalon is associated with lowering all-cause mortality and is often used in anti-aging protocols. AOD9604 is a fragment of human growth hormone, and it promotes fat burning. One of my top peptides right now is MOTS-c, which supports insulin sensitivity and mitochondrial health, which is especially great for active people. The earlier you start using peptides, the more beneficial they can be for you in restoring and maintaining your beauty and health. www.beautyculturespa.com @beautyculture.medspa
In this episode of the Optimised Health Show, we dive deep into the fascinating world of peptides—nature's biological messengers with incredible therapeutic potential. From muscle repair and immune modulation to skin health and anti-aging, peptides offer a cutting-edge approach to optimising health.We explore popular peptides like BPC-157, thymosin alpha-1, and copper peptides, discussing their benefits, dosing considerations, and best application methods—whether injectable, oral, or topical. We also break down the truth behind GLP-1 agonists (like Ozempic and Mounjaro) and why they can be game-changers for weight management and metabolic health when used correctly.But let's be real—there are no magic pills. We emphasise the importance of fundamentals—proper diet, exercise, and lifestyle—before turning to advanced tools like peptides. Plus, we share expert insights from thought leaders in the space, including Dr. William Seeds and Jay Campbell, and discuss the future of peptide therapy.Topics covered in this episode: ✔️ What are peptides and how do they work? ✔️ BPC-157 for healing, inflammation, and gut health ✔️ Thymosin alpha-1 for immune support and longevity ✔️ Copper peptides for skin, hair, and collagen production ✔️ The rise (and misuse) of GLP-1 agonists for fat loss ✔️ The challenges of peptide sourcing and regulation ✔️ Why lifestyle is STILL kingThanks to Our Sponsor:Want supplements that *actually* work? Check out Love Life Supplements and use code BEN10 for 10% off your order.Let's Stay Connected: Ben: @benlawprimal Sarah: @sarahlawuk Book a Consultation with Sarah: Free Wellness Discovery Call Thanks for Tuning In! Enjoyed this episode? Drop us a 5-star review and share it with your health-loving crew. Stay tuned for our next episode — we promise we won't ghost you again!
In this episode of Optimization Academy Podcast, we're joined by Dr. Morris and Dr. Asare B. Christian, two experts in integrative and regenerative medicine, who are transforming pain management with innovative approaches. From peptide therapies to regenerative injections, we're exploring the latest tools that help patients find relief and heal at a deeper level. Today's Topics - Meet Dr. Morris and Dr. Christian and hear how they transitioned from traditional to functional medicine, bringing new hope to patients dealing with pain and chronic conditions. (00:00 - 11:02) - Acute vs. Chronic Pain: The importance of understanding different types of pain and how it impacts treatment strategies, especially regarding inflammation management. (11:02 - 23:15) - When to consider imaging in chronic pain patients and how these results guide personalized treatment plans. (23:16 - 31:57) - Dr. Morris and Dr. Christian share their top lifestyle adjustments for reducing pain and inflammation naturally. (31:58 - 41:57) - Peptides for Pain Relief and Healing: A deep dive into peptides like Thymosin beta-4, Thymosin alpha-1, Pentadecapeptide Arginate (PDA), Pentosan Polysulfate, and CJC-1295/Ipamorelin, and how they support pain relief, recovery, and tissue repair. (41:58 - 1:09:32) Tune in for practical insights, cutting-edge therapies, and a fresh perspective on managing pain and inflammation. Whether you're a physician, wellness enthusiast, or someone exploring options for chronic pain, this episode has something for you! As always, thanks for tuning in! ***** Learn more about Dr. Christian: https://www.aethermedicine.com/who-we-are/doctor-christian/ ***** Learn more about Dr. Morris: https://www.amgmedicaltucson.com/ *****Click here to subscribe to our YouTube channel: https://www.youtube.com/channel/UCM2Jjqb7MqtZ7VDIuRjguLA/?sub_confirmation=1 *****Connect with Dr. Jones on Instagram: https://www.instagram.com/doctorjones_doctorjones/ *****Connect with Enovative Wellness Center on Facebook: https://www.facebook.com/GregJonesNMD
People often ask me, “What's the difference between Thymosin Beta-4 and TB-500?”—and it's a great question! These two peptides might seem the same, but they do have some important differences. In this podcast, we'll discuss the key differences between the two. 1. Origin and Structure Thymosin Beta-4 (Tβ4) is a naturally occurring peptide in the body, found in high concentrations in tissues like blood, wound fluids, and muscles. It plays a crucial role in cell migration, wound healing, and reducing inflammation. Tβ4 is a full-length peptide composed of 43 amino acids. TB-500 is a synthetic version of a smaller, more active segment of Thymosin Beta-4. It's designed to mimic the regenerative properties of Tβ4 while being more stable and easier to produce for therapeutic purposes. TB-500 typically consists of a shorter sequence of Tβ4, around 17 amino acids, the active region responsible for much of the healing and recovery benefits. 2. Purpose and Use Thymosin Beta-4 is used in research and experimental medicine to understand its broad biological functions. It is involved in promoting tissue repair, cell growth, and regeneration on a cellular level. TB-500 is primarily used as a therapeutic peptide for muscle recovery, wound healing, and reducing inflammation. It is often chosen because it is more cost-effective and easier to synthesize than the longer Tβ4 peptide. 3. Effects on the Body Thymosin Beta-4 has a wide range of biological effects, including promoting angiogenesis (forming new blood vessels), reducing inflammation, and supporting the migration of cells to injury sites. It also helps prevent fibrosis (scarring) and promotes hair growth and stem cell differentiation. TB-500 focuses more on specific healing and recovery functions. It has been shown to improve muscle recovery, speed up the healing of tendons and ligaments, and reduce inflammation, making it popular among athletes for injury recovery. However, TB-500 does not have all the broader effects that the full-length Thymosin Beta-4 peptide has. 4. Availability Thymosin Beta-4 is less commonly available in the market due to its complexity and cost of production. TB-500 is more widely available as a synthetic peptide and is commonly used in therapeutic and athletic settings due to its relative affordability and ease of use. It's important to be aware that some suppliers use the names TB-500 and Thymosin Beta-4 interchangeably, making it tricky to know exactly what you're buying. To ensure you're getting peptides from a reputable source, look for peptide clinics that use trusted compounding pharmacies that provide lab testing and certificates of analysis for each batch. Reputable pharmacies will also have clear product descriptions and will be transparent about sourcing, quality control, and regulatory compliance. 5. Administration Both Thymosin Beta-4 and TB-500 are usually administered via subcutaneous or intramuscular injections. However, due to the synthetic nature and shorter sequence of TB-500, it is typically more stable and easier to store and handle than the full-length Tβ4. The doses vary depending on the condition being treated, with higher doses typically used for more severe injuries or recovery needs, while maintenance doses are lower for ongoing healing or injury prevention. In summary, TB-500 provides a more practical approach to healing and recovery, while Thymosin Beta-4 offers a wider range of biological benefits but is less commonly used outside of research settings. Thanks again for listening to The Peptide Podcast. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week! We're huge advocates of elevating your health game with nutrition, supplements, and vitamins. Whether it's a daily boost or targeted support, we trust and use Momentous products to supercharge our wellness journey. Momentous only uses the highest-quality ingredients, and every single product is rigorously tested by independent third parties to ensure their products deliver on their promise to bring you the best supplements on the market. If you're ready to dive deeper into the world of nutrition, don't miss my new ebook, Eat Smart: Powerful Tips for a Healthier You, now available on Amazon! It's packed with easy-to-understand, science-backed tips to help you optimize your diet, boost metabolism, and reduce inflammation. The best part? If you have Kindle Unlimited, it's always free! So grab your copy today and start your journey to a healthier, smarter way of eating!
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In today's episode, we explore the role of Thymosin Alpha 1 Peptide in modulating the immune system, specifically its effects on Th1 and Th2 responses. The episode further delves into the mechanisms by which Borrelia burgdorferi evades immune detection and offers strategies to enhance immune effectiveness against this stealthy pathogen. Additionally, we discuss the broader implications of immune modulation in chronic Lyme disease and mold exposures. Topics: Introduction Recap of the series on Lyme and mold Highlighting the key steps in the biotoxin illness resolution process Importance of working with a medical professional Key Steps in Biotoxin Illness Resolution Lowering inflammation Lipid replacement therapy (phospholipids) Use of antimicrobial and antiparasitic herbs for Lyme and coinfections Employing binders to eliminate toxins and reduce inflammation Checking for MARCoNS and utilizing treatments like silver spray or biofilm busters (e.g., xylitol) Detoxification post-MARCoNS clearance using agents like chlorella and glutathione Assessing and normalizing various health markers (e.g., ADH, osmolality, MMP9, C4a, C3a, TGF-beta, sex hormones) Additional Resources and Episodes Early stages of Lyme infection and Herxheimer reaction: Episode 116 Chronic inflammation and biotoxin management: Episode 117 Role of binders in interrupting enterohepatic circulation and toxin elimination Discussion on Biofilm Importance of addressing biofilm in antimicrobial therapies Potential supplements and strategies (e.g., garlic, oil of oregano, stevia) Overview of Lyme Disease Impact & Immune Function Chronic inflammation due to miscommunication between the innate and adaptive immune systems + dysregulated adaptive responses How borrelia evades the immune responses Immunomodulation in Lyme Disease Background on immune modulation Role of T cells in adaptive immune response Th1 and Th2 cell imbalance in chronic Lyme Strategies to support Th1 cells and decrease Th2 response Focus on Thymosin Alpha 1 Benefits of Thymosin Alpha 1 in modulating immune function Promoting Th1 response and managing Th2 dominance Effects on regulatory T cells (Tregs) and immune tolerance Conclusion Reminder to work with a Lyme literate or biotoxin illness literate medical professional Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in! --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support
In today's episode, we go through the intricacies of lymphatic health in order to understand the mechanisms behind lymphatic congestion, fluid accumulation, and poor immune function. We highlight the pivotal role of white blood cells in orchestrating immune responses and emphasize diverse strategies for maintaining lymphatic flow. We go over herbal supplements, physical therapies, and peptide interventions, also evaluating whether or not they are research-backed. Topics: 1. Introduction to Lymphatic System and its Importance - Definition and Composition of Lymph - Functions of Lymphocytes (T cells, B cells, T cell types, and antibodies) 2. Components of the Lymphatic System - Lymphatic vessels - Lymph nodes - Bone marrow and thymus - Other lymphoid organs (Spleen, Tonsils, Adenoids, Peyer's patches) 3. Role of White Blood Cells (WBCs) in the Lymphatic System - Macrophages in innate immunity - Dendritic cells in antigen presentation - Adaptive immune response initiation 4. Causes and Effects of Lymphatic Congestion - Pathogen invasion and immune response - Inflammation and swelling of lymph nodes - Impaired lymphatic fluid flow and drainage 5. Strategies for Supporting Lymphatic Health - Herbal and Nutritional Support - Ginger, Ginseng, Cleavers, Red Clover, Echinacea, Burdock Root, Calendula - Physical Therapies - Exercise, Rebounding, Vibration Therapy, Manual Lymphatic Drainage - Peptide Therapies (Personal Thoughts & Use) - Thymosin alpha 1, Ovagen, Crystagen 6. Conclusion - Importance of holistic approach to lymphatic health - Always work with a licensed medical professional Thank you to our episode sponsor: Check out MoonBrew Here! Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in! --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support
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The aging process brings with it many changes. You might notice signs of aging, like gray hair and wrinkles. And some may experience health problems like dementia, heart disease, and certain types of cancer. You may also find that you get sick more often or don't recover as quickly from illness and injury as you did when you were younger. But why does this happen? It turns out that our immune system plays an important role in the aging process. Your immune system helps you fight infections. But as we age, our body's natural defense mechanism weakens, making us more vulnerable to diseases and infections. This is because your inflammation levels increase as you age. In recent years, scientists have been delving into the world of peptides, discovering their incredible potential in enhancing the aging immune system. In this podcast, we'll talk about why inflammation increases with age, how to test inflammation levels, and how to decrease your inflammation levels as you age (e.g., lifestyle changes and peptide therapy). What happens to the immune system as you age? As you age, inflammatory changes happen. While scientists don't know exactly why or how inflammation increases with age, some theories speculate it's due to increased stress in the body, cell damage from free radicals, DNA damage, and stem cell aging. There are also theories that cytokines (inflammatory chemicals) increase with age, leading to inflammation. It's important to remember that not all inflammation is harmful. We need inflammation to happen to help our bodies heal from injuries. But, chronic inflammation may cause Alzheimer's, Parkinson's, or heart disease. It may also cause type 2 diabetes and certain types of cancer. While aging can lead to chronic inflammation, other risk factors like obesity, smoking, low estrogen and testosterone levels, stress, lack of sleep, and a diet high in saturated and trans fats and sugars also increase the risk for inflammation. Can I test my inflammation levels? It's important to know that it's hard to measure inflammation. This is because lab tests don't tell you where or why there's inflammation. Lab tests can tell you if your lab value is abnormal, suggesting there is inflammation somewhere in your body. Lab tests typically used as markers for inflammation include complete blood counts (CBC), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and fibrinogen. How can I decrease my inflammation levels? Researchers are currently studying ways to slow inflammation levels as you age. Some studies suggest limiting the amount of calories you consume can decrease inflammation. Other studies show that increasing your intake of zinc or resveratrol (found in grapes and wine) may help prevent aging and reduce inflammation. There may be ways to improve your immune health through diet and physical activity. Eating less sugar and saturated and trans fats can help boost your immune system. You can also try to eat more fruits and vegetables. Blueberries, leafy green vegetables (e.g., spinach, kale, and broccoli), and cauliflower have high levels of antioxidants to help decrease inflammation. While fatty fish (e.g., salmon, tuna, trout, and sardines) are rich in omega-3 fatty acids to help lower levels of inflammation. Peptides and inflammation regulation Peptides have been studied for their anti-inflammatory properties, which can help regulate the immune response. By reducing excessive inflammation, peptides contribute to maintaining a healthy immune system, ensuring it functions optimally without causing harm to the body's tissues. Thymosin alpha 1 (TA1): In our bodies, TA1 is known as a natural senolytic, which induces the death of aging cells our thymus makes. Taking TA1 as peptide therapy mimics the body's natural release of TA1 in the thymus gland, which stimulates the production of T cells. It also decreases the production of specific proteins called cytokines that can cause chronic inflammatory or immune responses in some people (e.g., chronic fatigue syndrome and fibromyalgia). Studies have shown that people fighting infection have less circulating TA1 than healthy people. Antimicrobial Peptides (AMPs): Antimicrobial peptides, a diverse group of molecules found in various organisms, are our body's natural defense against bacteria, viruses, and fungi. For instance, LL-37, a human AMP, has shown remarkable efficacy against many pathogens. Scientists are now exploring synthetic versions of AMPs as potential treatments to combat infectious diseases, boosting our immune system's ability to fight harmful invaders. Gut-Brain Peptides: The gut plays a significant role in our overall immune health, housing a vast network of immune cells. Peptides such as BPC -157 and β-casomorphins, derived from milk proteins, have been studied for their impact on the gut-brain axis. By nurturing a healthy gut environment, these peptides indirectly support the immune system, ensuring it functions optimally. Epitalon: Epitalon is a synthetic peptide that has been studied for its potential to slow down the aging process. It works by stimulating the production of telomerase, an enzyme that protects and lengthens telomeres, the protective caps on the ends of chromosomes. Telomeres naturally shorten as cells divide, a process associated with aging. Epitalon has shown promise in rejuvenating immune cells by preserving telomere length, promoting a more youthful and robust immune system in aging individuals. Epitalon also acts as an antioxidant that eliminates free radicals responsible for damaging and killing cells. Free radicals are unstable atoms that can damage cells, causing illness and aging. In turn, Epitalon plays an important role in helping to suppress cancerous tumor growth. Thanks again for listening to The Peptide Podcast, we love having you as part of our community. If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week! Pro Tips We're huge advocates of using daily greens in your routine to help with gut, skin, nail, bone, and joint health. We take AG1 (athletic greens) every day. Not only does it have vitamins, minerals, and a diverse range of whole-food sourced ingredients, but it also has probiotics to promote a healthy gut microbiome and adaptogens to help with focus and mood balance. It's vegan, paleo, and keto-friendly.
Welcome to another episode of The Synthesis of Wellness Podcast! Today, we are talking all about my latest n=1 experiment: using the FlexBeam (a red and infrared light therapy device) on my gut microbiome. Then, we transition into cosmetic peptides with an emphasis on TB-500 for stimulating and accelerating hair growth! Thanks so much for tuning in! Topics: 1. Introduction - Biohacking congress in Miami - Invitation to connect with me for meet-ups and ticket discounts 2. Red and Infrared Light Therapy - Introduction to the red light and infrared therapy device (FlexBeam) - Description of the device's features and capabilities - Explanation of its ability to penetrate up to 10cm within the body - Interest in exploring the impact of red and near-infrared light on the gut microbiome - Self-experiment! 3. Scientific Context - Definition of Photobiomodulation and its healing properties - Mention of studies exploring the effects of light therapy on the gut microbiome - Discussion of the impact of Photobiomodulation on gut microbial diversity 4. Human Microbiome Studies** - Mention of preliminary unpublished work using Photobiomodulation on the human microbiome - Increases in Akkermansia muciniphila, Bifidobacterium sp., and Faecalibacterium sp. - Impact on the Firmicutes:Bacteroides ratio as an indicator of gut health 5. Personal Experiment - Experiment using the FlexBeam device with both red and infrared light - Explanation of the wavelengths used in the experiment - Description of the experiment's frequency and duration - Excitement about the potential results and anecdotal observations 6. Transition to Cosmetic Peptides - Introduction to the topic of cosmetic peptides - Focus on thymosin beta-4 and its various uses 7. Thymosin Beta-4 for Hair Growth - Background information on thymosin beta-4 - Discussion of the hair follicle structure and growth cycle - Explanation of the anagen, catagen, and telogen phases - Role of stem cells in the bulge area during anagen phase - Overview of the acceleration of stem cell migration due to thymosin beta-4 8. Stem Cell Migration and Hair Growth - Significance of stem cell migration in hair follicle growth - Natural expression of thymosin beta 4 during anagen phase - Migration of cells from the bulge to the bulb region 9. Effectiveness and Administration - Discussion on the effectiveness of thymosin beta-4 for hair growth - Mention of a study using topical thymosin beta-4 on shaved rats - Role of angiogenesis in promoting blood flow to the scalp - Connection between inflammation and decreased blood flow 10. Application Methods - Topical application in most studies - Mention of subcutaneous injections for broader repair/regeneration - Emphasis on working with licensed physicians 11. Conclusion - Acknowledgment of individual variability in hair growth approaches - Reminder of the importance of addressing root causes of hair loss Thanks so much for tuning in! If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in! --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support
What are PEPTIDES? Today we are talking about how to use peptides for greater health!These are the peptides covered in this video: BPC 157TB 500 (Thymosin beta 4 or TB4)TA1 (thymosin alpha 1)EpitalonDohexaCerebrolysinSelankSemaxPE-22-28IpramorelinCJC 1295TesamorelinMOTS-cSemaglutide5-amino-1-MQMelanotanLL37PT 141GHK-CuDo you have any questions? Reach out at:https://uplyftcenter.com/contact/To Connect With Dr. Joy Kong:http://drjoykong.com/Watch Video Episodes on YouTube:https://www.youtube.com/channel/UCZj1GQBWFM5sRAL0iQfcMAQFollow Dr. Joy Kong on Social Media:https://www.instagram.com/dr_joy_kong/https://www.facebook.com/stemcelldrjoyhttps://www.linkedin.com/in/joy-kong-md-4b8627123/For more information about anti-aging regenerative medicine treatment visit:https://uplyftcenter.com *Our content is for informational purposes only and should not be treated as medical or health advice. Please consult with your doctor / healthcare provider if you have any questions about your medical conditions.*
Welcome to another episode of The Synthesis of Wellness Podcast! This is a full-on guide to hair growth, hair loss, scalp health, conditions that could impact hair health, toxins to be aware of, blood tests to get when experiencing hair loss, strategies and treatments that may help, and a lot of nitty gritty details in between. Topics: - Basic anatomy of a hair follicle - Hair growth cycle: 3 phases - How stem cells are involved in the hair growth cycle, specifically the anagen phase - What factors can disrupt stem cell proliferation and, therefore, hair growth - Blood tests that might be helpful in assessing why someone is losing hair: heavy metals, hormones, micronutrient, and stealth infections - Increasing blood flow to the scalp - Increasing scalp oxygenation - PRP - Natural DHT blockers vs. minoxidil - Two topical peptides: AHK-Cu and Thymosin beta-4 Thanks for tuning in! If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness, or use the link: https://www.instagram.com/synthesisofwellness/ Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in! --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support
Today we're going to talk about things you can do over time to help boost your immune system and thymosin alpha 1 (TA1), a peptide therapy used for immune support. Most of us know that there are certain things we can do to limit our exposure to germs that can make us sick. Things like washing our hands with soap and water or hand sanitizer and keeping high-touch areas clean can limit your exposure to germs. But there are other things we can do over time to boost our immunity and create a stronger immune system. What works to boost our immune system? A balanced approach to your diet is important. Your meals should include a variety of fruits and vegetables, whole grains, and healthy protein sources (legumes, nuts, fresh fish, low-fat dairy, or lean cuts of meat). Try to avoid refined sugars, which are usually found in processed foods. These include foods like packaged snacks, candy, soda, and cereals. These foods can increase inflammation and can dampen a strong immune response. They can also leave you feeling tired and have been linked to weight gain, type 2 diabetes, and heart disease. Sometimes it can be difficult to tell if food is processed. But reading the ingredients can help if you're not sure. If any ingredient listed on the label isn't used in kitchens, it's probably processed food. Examples include fructose, high-fructose corn syrup, maltodextrin, and lactose, to name a few. Clinical studies have shown that physical activity affects the immune system. In fact, regular exercise can boost the immune system, provide additional energy, promote restful sleep, and help lower your risk of type 2 diabetes, heart disease, and cancer. It can even help reduce chronic pain and stress, which may help improve your mood. But how often should you exercise? The American Heart Association recommends weekly 150 minutes of moderate aerobic activity (e.g., water aerobics, dancing, or gardening) or 75 minutes of vigorous aerobic exercise (e.g., running, swimming laps, or jumping rope). It also recommends two days of muscle-strengthening activities like resistance or weight training, yoga, or pilates. It's recommended that older adults should also include balance training in their exercise routines (e.g., tai chi, heel-to-toe walking, or balancing on one leg). These exercises improve coordination and stability and may help prevent falls. Fun fact: Your immune system is activated during sleep. But how much sleep do you need? Individual sleeping requirements vary depending on age, overall health, medications, underlying sleep disorders, and lifestyle. For example, the National Sleep Foundation recommends that adults ages 18 to 60 get 7 or more hours per night while adults 61 to 64 get 7 to 9 hours per night. If you're 65 years and older, getting 7 to 8 hours of sleep per night is recommended. Not getting enough sleep may increase inflammation or decrease your immune response. Lack of sleep can also worsen or lead to chronic diseases like depression, diabetes, high blood pressure, heart disease, stroke, and unintentional weight gain. Excessive alcohol consumption can weaken the immune system. Alcohol can damage the lining of the gut, causing inflammation, infections, and stomach ulcers. A heavier body weight can dampen the immune system and increase the risk of infections. This is because there are fewer infection-fighting immune cells, and excess body fat contributes to inflammation. What peptide may help to enhance immune function? Thymosin alpha 1 (TA1) has been shown to enhance the function of certain immune cells. TA1 has been shown to exhibit antibacterial and antiviral properties, suppress tumor growth, and promote wound and tissue healing. TA1 is used for clinical conditions where immune support is needed. Zadaxin is a TA1 peptide evaluated and approved in 30 countries for treating hepatitis B & C, HIV, and AIDS. It's also used with chemotherapy for certain lung, liver, and skin cancer patients. In addition, it is used in people with DiGeorge syndrome and has shown promising results in treating Lyme disease. Currently, the medication is in Phase III trials for treating hepatitis C and Phase II trials for hepatitis B in the United States. How do I take TA1? The peptide injection is subcutaneous (injected into the fatty tissue) once daily. For viral infections, treatments usually last for 2 weeks. But, depending on what you're treating and how serious your infection is, treatment could last 3 months or more. The dose depends on why you're taking it. What are the possible side effects of TA1? Possible side effects include redness, itching, or swelling at the injection site. As always, you should tell your healthcare provider about any side effects you experience. Thanks again for listening to The Peptide Podcast, we love having you as part of our community. If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week! Pro Tips We're huge advocates of using daily collagen peptide supplements in your routine to help with skin, nail, bone, and joint health. But what do you know about peptides for health and wellness? Giving yourself a peptide injection can be scary or confusing. But we've got you covered. Check out 6 tips to make peptide injections easier. And, make sure you have the supplies you'll need. This may include syringes, needles, alcohol pads, and a sharps container.
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.01.23.525258v1?rss=1 Authors: Borchelt, D. R., Ellison, S. Abstract: Amyotrohpic lateral sclerosis (ALS) is a progressive neurodegenerative disease that causes generalized muscle weakness and atrophy. Neuropathologically, ALS is defined by severe loss of upper and lower motor neurons with a robust neuroinflammatory response. In the present study, we have examined the potential utility of two drugs that have indications as immune modulators, levamisole HCl and thymosin 1. These drugs were tested in two models models that reproduce aspects of ALS. We conducted a 14 week dosing study of these two drugs in the SOD1G93A and Prp-TDP43A315T models of ALS. The drugs were given once daily for two weeks and then every other day for 6 weeks for a total of 8 weeks of treatment. Outcome measurements included efficacy assessment on the neuromuscular phenotypes, and pathological analyses of ubiquitin load and neuro-inflammatory markers in spinal motor neurons. Neither of these drug treatments produced significant extensions in survival; however, there were changes in ubiquitin load in SOD1G93A mice that suggest the drugs could be beneficial as additions to other therapies. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
See all the Healthcasts at https://www.biobalancehealth.com/healthcast-blog The best way to decrease you risk of developing illness and cancer, as well as a cancer recurrence, is to get your immune system as healthy as possible. Everyone's body makes cancer cells daily, but your amazing immune system protects you by killing them before they multiply. The key to preventing chronic illness, cancer, and a cancer recurrence, infections such as viruses or bacteria, and chronic fatigue is to turn the clock backwards to when you were young and your immune system's “power center”, the thymus gland, was large and active. The thymus gland makes T Killer and T helper white blood cells that kill cancer and bacteria. The thymus gland is key to your immune system, and it shrinks with age. It is large and active when we are children and gets smaller and less active as we age. After age 60 you may notice that people get sicker and that is when they have the most frequent cancer diagnoses. The thymus gland can be stimulated again by “feeding” it and stimulating it into action again. The best way to improve your immune system's health and reverse the thymus's aging process is to make your thymus more active, like it was when you were younger. The best way to achieve this is to replace testosterone, stimulate growth hormone (if necessary), eat healthy food and avoid unhealthy food, add daily exercise to your lifestyle, achieve ideal weight, take supplements, and use immune-boosting peptides like Thymosin alpha-1 or Thymulin and or take medications like Metformin ER. The following lists are meant to be helpful for you to improve the status of your immune system. Medications/Hormone Prescriptions that improve Immunity: Testosterone pellets and injections Metformin ER 500 mg-2,000 mg Thymosin alpha-1 peptide (currently unavailable) Thymulin peptide Peptides that stimulate the Growth Hormone. Eg. Sermorelin, Ipamorelin, CJC.. Supplements that Support your Immune System & Recommended Daily Dosing: Vitamin C - 1,000 mg/day Vitamin D3 - 5,000 IU/day Zinc - 30-50 mg/day Methyl-B Complex from BioBalance Health - 1 /day Magnesium Glycinate or Magnesium Complex from BioBalance Health - 400-800/day N-Acetyl Cysteine (NAC) from BioBalance Health – 1800 mg/day Inositol 1-2 grams a day Choline 425-550 per day Glutathione (given im, IV optimally) 50-600 mg/day orally (20-40 mg/kg of body weight 3 x a day) Airborn® Diet: Lots of fresh fruits, vegetables, eggs, and animal protein (meat and milk products) Citrus fruit Limit caffeine to no more than 2 cups/day Avoid sugar, synthetic sugars (Saccharin, Equal®), alcohol, gluten, and processed foods Avoid preservatives, and food coloring/dyes (especially Red #40 & Yellow #5) Exercise: Doing 45min of cardio per day or more is optimal! Add weight training for the whole body. Red Light Therapy: 20 minutes a day stimulates the mitochondria to make more immune cells, and to activate them. Sunshine: 45-60min/day is optimal! No sunglasses or sunscreen. Medications to AVOID: Statins Steroids Drugs that treat autoimmune disease called biologics Medical Treatments to avoid if possible that Suppress the Immune System Immune suppressants Treatments for autoimmune diseases Cancer treatments such as radiation and chemotherapy Habits and substances to avoid that suppress the immune response (the thymus gland and the cells that it produces. Avoid the habits and environmental substances that follow: All types of tobacco products Smoking anything—tobacco, THC, etc. causes the lungs to be damaged and to carry carcinogens into the body. You can put an air purifier in your home and or office. Alcohol, yes including wine and beer (they are toxins) Drugs not prescribed by a doctor and some that are prescribed by a doctor. See “Medications to Avoid” above. Fast food Sugar, honey, simple carbohydrates that raise the blood sugar Inactivity Short lengths of sleeping. Humans need at least 7 hours of sleep. Night work/shift work Indoor light > outdoor sun light Tap water that contains chemicals and fluoride--only drink purified water Use of chemicals on your lawn and pesticides in and outside of your home because they are carcinogens No one can avoid all bad habits and substances that block your production of White Blood cells and protect you from cancer, autoimmune diseases and infections, however you can take steps to improve your immune system to decrease your chance of these diseases. The most important change you can make that protects you with just one change is to replace testosterone with bioidentical pellets, if you are over 40 years old. Testosterone in pellet form is the one hormonal replacement that will improve your immune status more than any other single treatment or supplement. So what is stopping you from preventing future illness and suffering?
Today we are talking about Thymosin beta 4 (TB4 or TB500) and its potential benefits. All this and more in less than 2 minutes. Last week we talked about Thymosin alpha 1 and the importance of the thymus gland and T cells. Before we get into what TB500 is and does, it's important to know that although it is naturally found in the thymus, TB500 is found in most cells and tissues, except red blood cells. What is Thymosin beta 4 (TB4 or TB500)? TB500 works by binding actin (proteins that makeup 10% of the total proteins in cells). Actin helps with cell division, signaling, and shape. It also speeds up the rate of new tissue growth and new blood vessel formation. This helps wounds heal. It also decreases inflammation and scarring when applied to wounds. In the body, T500 levels rise significantly in areas where tissues have been damaged so these areas can be repaired. This is great for those looking to speed up injuries or wounds that are healing slowly. It's also a good option for chronic injuries that don't seem to heal quickly. What are the BENEFITS? When we take TB500 as peptide therapy, it's used for clinical conditions where soft tissue repair, skin, hair growth, and chronic pain management are needed. It's also been used in people post heart attack to help repair tissue damage and has been clinically shown to improve symptoms of moderate to severe dry eye. RGN-259 by RegeneRx Pharmaceuticals is a TB4-based eye drop for dry eye syndrome. It's currently in Phase II trials in the United States. RGN-352 is a TB4-based injectable drug to prevent and restore heart attack and stroke tissue damage. This medication is currently in Phase II trials. How do I take TB4/TB500? TB500 is given as a subcutaneous peptide injection (into the fatty tissue) daily. It's suggested that this peptide be used no longer than 12 weeks and stopped for at least one month. Studies suggest prolonged use could lead to dependency. Possible side effects include redness, itching, or swelling at the injection site. Rare cases of tiredness and drowsiness can happen. As always, you should tell your healthcare provider about any side effects you experience. You can find more information at pepties.com. That's peptides without the D. Where we are tying all the peptide information together in one easy place. Thanks again for listening to The Peptide Podcast. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media. And subscribe to our podcast. Have a happy, healthy week! Pro Tips Giving yourself a peptide injection can be scary or confusing. But we've got you covered. Check out 6 tips to make peptide injections easier. And, make sure you have the supplies you'll need. This may include syringes, needles, alcohol pads, and a sharps container. We're huge advocates of using daily collagen peptide supplements in your routine to help with skin, nail, bone, and joint health. They also help with anti-aging. Our favorite collagen peptide powder is Thorne® Collagen Plus.
Today we are talking about Thymosin alpha-1 (TA1) and its potential benefits. All this and more in less than 2 minutes. Before we get into what TA1 is and does, we need to talk about the thymus gland. Your thymus gland is a small gland located in your upper chest behind your breastbone in the lymphatic system. It makes special white blood cells called T-cells. There are two types of T-cells: killer T cells and helper T cells. Both help your immune system fight disease and infection. Killer T cells destroy cancerous cells and cells infected with a virus. Helper T cells work with the other cells of the immune system to make an immune response. What is Thymosin alpha 1 (TA1)? TA1 is a peptide that's produced naturally by the thymus gland. As we age, our thymus gland shrinks (atrophies), and this affects the production of TA1. In our bodies, TA1 is known as a natural senolytic, which induces the death of aging cells our thymus makes. Taking TA1 as peptide therapy works by mimicking the body's natural release of TA1 in the thymus gland, which stimulates the production of T cells. It also decreases the production of certain proteins called cytokines that can cause chronic inflammatory or immune responses in some people (e.g., chronic fatigue syndrome and fibromyalgia). Studies have shown that people fighting infection have a lower amount of circulating TA1 than healthy people. What are the BENEFITS? TA1 is used for clinical conditions where immune support is needed. Zadaxin is a TA1 peptide evaluated and approved in 30 countries for treating hepatitis B & C, HIV, and AIDS. It's also used along with chemotherapy for certain lung, liver, and skin cancer patients. In addition, it is used in people with DiGeorge syndrome. Currently, the medication is in Phase III trials for the treatment of hepatitis C and Phase II trials for hepatitis B in the United States. Fun fact: TA1 has an Orphan Drug approval by the FDA for several indications. Orphan drugs are medications approved by the FDA for rare conditions that affect fewer than 200,000 people in the U.S. TA1 has also shown promising results in the treatment of Lyme disease. How do I take TA1? Compared to other peptide therapies, TA1 has a longer half-life of 2 hours, requiring fewer peptide injections. The peptide injection is a subcutaneous injection (injected into the fatty tissue) once every third day. For viral infections, treatments usually last for 2 weeks. But, depending on what you're treating and how serious your infection is, treatment could last 3 months or more. Possible side effects include redness, itching, or swelling at the injection site. Rare cases of increases in liver enzymes have happened. If you have signs of liver injury (nausea or vomiting, yellowing of the skin or eyes (jaundice), or stomach pain tell your healthcare provider right away. As always, you should tell your healthcare provider about any side effects you experience. You can find more information at pepties.com. That's peptides without the D. Where we are tying all the peptide information together in one easy place. Thanks again for listening to The Peptide Podcast. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media. And subscribe to our podcast. Have a happy, healthy week! Pro Tips Giving yourself a peptide injection can be scary or confusing. But we've got you covered. Check out 6 tips to make peptide injections easier. And, make sure you have the supplies you'll need. This may include syringes, needles, alcohol pads, and a sharps container. We're huge advocates of using daily collagen peptide supplements in your routine to help with skin, nail, bone, and joint health. They also help with anti-aging. Our favorite collagen peptide powder is Thorne® Collagen Plus.
Episode 34 - Payment Processors Block PED Sales, Enclomiphene Banned, Thymosin Alpha 1, Immune System HelpTest Your Levels Linkshttps://taplink.cc/testyourlevelsYoutube Channel - https://www.youtube.com/channel/UC-xAd1-SQ6ooGpXiu_Uln6wInstagram - https://www.instagram.com/testyourlevels/TikTok - https://www.tiktok.com/@testyourlevels?Sam Stolts Linkshttp://bit.ly/sam-stolt-linksYoutube Channel - https://www.youtube.com/channel/UCAOWpCd7-DhAGs8BR3y8_HQInstagram - https://www.instagram.com/sam.stolt/TikTok - https://www.tiktok.com/@sam.a.stolt?David Demesquita Linkshttps://taplink.cc/dynamite_dYoutube Channel - https://www.youtube.com/channel/UCxjheFb2GYN1iHdPgFjzwCQInstagram - https://www.instagram.com/dynamite_d/#MensHealthPodcast #TestosteronePodcast #BodybuildingPodcast
Evolutionary radio presents another exciting podcast. Host Stevesmi is joined by co-host Rick . Original content geared, no pun intended, to help you get the most of your workouts. This time they bring back 2 older episodes back to life. #344: 1. Nutrobal MK-677 info 2. Where it came from 3. What to look for 4. Ideas on dosing 5. Side effects https://www.evolutionary.org/evolutionary-org-podcast-344-sarms-mk-677-nutrobal/ #380 TB-500 1. Trying it 2. History 3. Aiding your fitness goals 4. What dosages do people use? https://www.evolutionary.org/evolutionary-org-podcast-380-tb500-healing-peptide-heal-bones-ligaments-and-tendons/ where/how to get bloodwork> https://www.evolutionary.org/forums/source-talk/bloodwork-private-md-5695.html >>>>>>>>>> for 1 on 1 coaching/consultation/source help requests hit up stevesmi https://www.elitefitness.com/forum/members/stevesmi.html https://www.evolutionary.org/forums/members/stevesmi.html to follow along with RickyV Follow Ricky on Social: http://www.rickyvrock.com/ Follow Ricky and ask him anything: http://www.bigrickrock.com/ Check out the Evolutionary Radio Podcast: https://www.evolutionary.org/podcasts/ Check out the EliteFitness Podcast: https://www.elitefitness.com/articles/podcast
In the March 24, 2022 episode of Better Than Ever Live!, I discuss a popular peptide called Thymosin Beta 4. If you haven't heard about it, we will discuss what TB4 is, how it works, what conditions it might help treat, and talk about how to potentially use it and where to get it. Subscribe […] The post 50. Thymosin Beta 4 for injury recovery and more! appeared first on Dr. David Geier - Feel and Perform Better Than Ever.
See all the Healthcasts at https://www.biobalancehealth.com/healthcast-blog/ If you ever wondered if there was something other than anti-cancer chemicals, quarantine or vaccines to help protect you from cancer and viral illness, there is a safe, inexpensive and effective medical treatment. Why haven't you heard of this wonder drug? The FDA has blocked the US population from access to this immune stimulator in the middle of a pandemic! I can't tell you why, except that it gave us a way to improve our immune status without other preventive treatments. It is not dangerous so you can only imagine your own reasons for this action. ‘In this blog I am going to inform you of this option so your will know about it and possibly help drop the ban on compounding pharmacies from making this communicator protein. I have included quotes from medical and scientific journals to support my information. At the end of the blog, I will list the sources for my information in case you question my information, you can look it up! “Thymosin alpha 1 is a peptide naturally occurring in the thymus that has long been recognized for modifying, enhancing, and restoring immune function. Thymosin alpha 1 has been utilized in the treatment of immunocompromised states and malignancies, as an enhancer of vaccine response, and as a means of curbing morbidity and mortality in sepsis and numerous infections “, World Journal of Virology 2020 Dec 15; 9: 67-78. This “bit of protein” is called a peptide, and it is just one of thousands of peptide communicators produced by the human body. When we are young and healthy these communicators are all working well in healthy mature adults, but as we age, we lose the ability to produce many of the peptides that keep us healthy, like Thymosin alpha 1. This is the reason that people over 60 get sick and die from infections that don't kill younger people. In the Journal of Virology this information was written in December of 2020, during the Covid Pandemic: Studies have postulated that thymosin alpha 1 could help improve the outcome in severely ill corona virus disease 2019 patients by repairing damage caused by overactivation of lymphocytic immunity and how thymosin alpha 1 could prevent the excessive activation of T cells. …. thymosin alpha 1 deserves further investigation into its antiviral properties and possible repurposing as a treatment against severe acute respiratory syndrome coronavirus-2. What does Thymosin Alpha 1 do? Thymosin alpha-1 (TA1) functions as a stimulator to the thymus gland. This gland produces white blood cells including but not limited to T-Killer cells and T helper cells (CD4+/CD8+ T cells) those WBCs that kill viruses, bacteria, fungus, and cancer cells. The thymus gland is located behind the “breastbone” and is largest when we are born and shrinks as we age. As it gets smaller, our immunity to everything decreases which is why older people get more severe infections and take longer to heal, and why older people need stronger vaccinations than younger people to get the same effect. TA1 has many functions other than increasing the number of T cells, it also increases their killing ability and modulates the T cells, so they respond to both abnormally directed immune responses (autoimmune diseases) and stimulates the activity of T cells against infections. TA1 decreases inflammation and is effective in treating pancreatitis and Hepatitis C. Regarding viruses TA1 decreases viral replication, therefore limits both the infections, communicability, and the severity of all viral infections. For cancer patients this peptide is amazing at limiting both incidence and growth of cancers. It is unparalleled in its activity against cancer recurrence. ..thymosin alpha 1 works via two main mechanisms: Either stimulating the immune system or employing its anti-proliferative activities on tumor cells. The protective action of thymosin alpha 1 against oxidative damage because of its effect on liver superoxide dismutase and glutathione peroxidase has been explored by Armutcu et al [26]. I have given TA1 to patients who have small tumors or failure of cancer treatment, when there is no more treatment left for them, to stimulate their own immune system to kill cancer cells. There are basically 3 other ways to kill cancer. Surgically remove it, kill it with chemicals that also kill beneficial cells in your body (chemotherapy), or radiate the area of cancer. However mainstream medicine rarely uses the fourth most effective and least dangerous method of stimulating the natural immune system and preventing and killing cancer. One of the unused methods of killing cancer cells is prescribing TA1 which stimulates your own immune system to kill cancer cells. This fact is rarely discussed by doctors, but it is a fact that everyone produces cancer cells in their bodies daily and when they are young and healthy their own immune system kills those cancer cells. When we are young, cancer is rare because our immune cells are activated by TA1 produced in our own thymus glands. As we age, our thymus shrinks, our TA1 decreases and some of these abnormal cells are missed and not killed, which allows these cells to grow and proliferate into what we call cancer. The true cause of cancer is the loss of normal immunity (TA1) to kill cancer cells. Due to the action of thymosin alpha 1 on other cell types, it is used as a therapeutic agent for diseases with evident immune dysfunction [4]. Clinical trials with thymosin alpha 1 for diseases like DiGeorge syndrome, non-small cell lung cancer, hepatocellular carcinoma, hepatitis B and C, HIV, and melanoma have been conducted and yielded promising results. FDA approved the orphan drug thymalfasin (Zadaxin) for treatment of malignant melanoma, chronic active hepatitis B, DiGeorge anomaly with immune defects, and hepatocellular carcinoma due to its immunomodulatory and anti-tumor effect. These diseases are the ones approved by the FDA for treatment with Thymosin alpha 1, in the form of the pharmaceutical called Thymalfasin, however they have ignored the elephant in the room: Thyomsin alpha 1 is effective against cancer, and preventing cancer recurrence, autoimmune diseases, viruses, parasites and bacterial infections. Why isn't it used in the US to stimulate our own thymus to act like it did when we were younger? I can't understand it! When we needed this compounded drug the most—in the middle of a pandemic, the FDA prevented all the compounding pharmacies from making it! This could have been an answer for those people who could not or would not get vaccinated, but in the beginning of the pandemic, production was shut down! Thymosin alpha 1 works and there is a lot of research to back this up, but it is unattainable in the US since Covid started. I had several patients with recurrent cancer on this peptide for years before the pandemic, and it prevented a recurrence. These patients got their medication from compounding pharmacies, and it had to be discontinued because no compounding pharmacy was allowed to make it. Why? Both patients, who had. exhausted their mainstream medical options for their cancer, are now experiencing a recurrence of their cancer without being able to get this drug. With all this proof and knowledge about the power of Thymosin alpha1, to prevent and treat viral illnesses and cancer, why have you never heard of it, especially at a time of pandemic when this peptide could do so much good to prevent and treat the virus that is causing our pandemic, especially for those people with immune dysfunction, cancer, autoimmune diseases, and immune senescence of aging? First, the government enacted an FDA letter to all doctors threatening discipline for doctors and healthcare workers who recommended “unproven” therapies for the Covid virus. Included in this new law, rule, is to silence anyone saying to their patients that Vitamin D (which has now been proven to protect against Covid), Quercetin which has supporting evidence in the medical literature to prevent the recommendation of doctors to patients from suggesting these methods of preventing supplements to our patients. If anyone can explain why our own government is working against us (both patients and doctors who are working to save lives), and using our tax dollars to do it, please tell me. I always thought being a doctor in America meant being able to use any safe and effective means that I know works effectively, to treat my patients. Doctors were effectively gagged by the FDA letter sent in December 2020, from telling my patients about preventive medicine practices that stimulate the immune system and protect us from infection. Now I have lost respect for the government who treats us all like we are uneducated and sheep who will follow whatever they tell us. They use the one size fits all in a decade when the practice of medicine is becoming more aware of the individuality of patients especially in the melting pot of the US. Drugs are ridiculously expensive and unaffordable except for the very rich. We often use compounding pharmacies for alternatives to this price burden for patients and offer inexpensive alternatives that patients can afford. I am listing the medical references that support my information. I don't generally do this but I believe it is important to support my blog. References: World Journal of Virology: Thymosin alpha 1: A comprehensive review of the literature, 2020 Dec 15; 9: 67-78. Regulatory Focus, webpage, FDA Targets Remdesevir , Thymosin Alpha In Compounding ,concerns, posted Feb 24 2021 by Kari Oakes. American Journal Health System Pharmacy. May 15, 2001;58(10):878-885.
See all the Healthcast at https://www.biobalancehealth.com/healthcast-blog/ Testosterone treats many illnesses in addition to sexual dysfunction. Most patients and doctors don't associate testosterone with the anxiety and depression that occurs after age 40. Depression is a direct side effect of low T. T is a mood elevator and stimulates Seratonin production, improving mood in that way. Many of our patients can decrease the dose of antidepressants or even go off their medications after they have been on T for more than 4 months. I always ask my patients to ask their “depression doctor”, who prescribed the antidepressant, to help them wean off. A side note: I do not recommend decreasing or stopping antidepressants during the fall, because we live in the Midwest and there is very little sunlight at our latitude between September to February, so I ask that they don't change their antidepressant during those months. Remember testosterone if you develop depression after the age of 40. Testosterone also treats anxiety in both men and women by lowering FSH and LH, the pituitary hormones that surge after T and Estradiol decrease with age. Many men come in to see me for low T and ED, who have recently been prescribed Xanax or some other antianxiety drug that is not working for their anxiety. However, when I treat them with testosterone pellets, they miraculously are cured of their anxiety! Women generally have hot flashes from elevated FSH/LH, however some of them have anxiety as well. Women are cured of their anxiety attacks, with T pellets plus or minus Estradiol. Other conditions that are improved when I treat my patients of both sexes with T pellets is Insulin resistance, AODM, and weight gain. T improves insulin resistance and increases the calorie burning in the muscles. You burn most of your calories every day in your muscles and T facilitates the metabolic work in the muscle tissue. With testosterone, you literally burn more calories by jut breathing (your Basal Metabolic Rate). T increases your muscle's activity by burning more calories of fat and stabilizes your blood sugar. Our patients lose fat, gain muscle mass, and become more insulin sensitive with T pellets. Those with diabetes decrease their medication over time and have a lot more energy…the natural way…by activating their muscles! Immune dysfunction occurs when you age and is why older people need a higher dosage of immunizations, and why they die of viruses that younger people don't die of. Your immune system is controlled by your thymus gland which makes white cells called T killer cells, T helper cells that kill cancer cells and viruses. B cells make antibodies. The thymus and its function is growth hormone and testosterone dependent. As growth hormone and T decrease, the gland shrinks and by age 50, and by age 60 it can't be seen and stops doing its job of protecting us. By taking testosterone, growth hormone is stimulated, and the thymus gland grows and is active making these cells that protect us. There is a peptide that stimulates the thymus for those people who don't fully respond to Testosterone, called Thymosin alpha-1. This is a communication peptide that stimulates the production of protective immune cells. It has been around forever as a medication, but no one used it because it doesn't have a big drug company behind it…so it is available at compounding pharmacies. The FDA has started to stamp it out across the US, for no apparent reason. It improves immunity to all infections. In this time of pandemic, this drug should be applauded and not taken off the market! What are they thinking? Autoimmune diseases occur when your immune system, your T Cells and B Cells, become confused and instead of killing viruses and bacteria, attack your own healthy tissue. This imbalance occurs secondary to a genetic weakness as well as exposure to infections that “look like” normal tissue. Testosterone deficiency causes an unstable immune system and leaves the door open for autoimmune diseases. I was very surprised when my patients with autoimmune diseases like RA, Lupus, and Sarcoidosis, improved drastically after they got T for completely different indications! I then researched this association between T and Autoimmune diseases and found that there is a lot of research that proves T is an excellent treatment and prevention for autoimmune diseases. Migraine Headaches response to T replacement, were another surprise for me. As I treated sexual dysfunction in women, they came in to see me and said: “The weirdest thing occurred after I got my pellets…I stopped having the incapacitating migraines I used to get! This is an amazing two-for….I have stopped taking my migraine medicine!” . Once again, I went to the research and found that hormonal migraines can be treated with non-oral testosterone. The migraines that are triggered by food additive and weather changes are usually not improved, but women have hormonal imbalance migraines, and T works for that. Why? Testosterone is a modulating hormone for many systems, but in this circumstance, it is working in the brain to balance the neurotransmitters and the vasodilation chemicals that get “confused” when it is deficient, and the effects of E2 increased and dilated blood vessels. PMS is another problem that is improved with testosterone. PMS affects every part of a woman's body…It is the outcome of estrogen dominance with a progesterone deficiency. This era of a woman's life can occur at any time in her life; however, it is much worse during after age 40. Why is that? Because after 40, testosterone becomes deficient, estrogen is dominant, and ovulation becomes spotty which is the function that produces progesterone. Weakness and loss of strength occurs after age 40 in women and some men, and this is directly due to the loss of Testosterone and the decrease of T free. This dominos to a less active person, and this results in osteoporosis and frailty. Here is a news flash…Frailty is the one thing that will cause a person to become dependent on others and unable to live independently! Losing muscle is not what you want! Testosterone prevents frailty, by directly stimulating muscle mass and strength, including the heart, which is a muscle, and by stimulating growth hormone which also builds muscle and bone! You get so much more than a good sex life (Which should be good enough) when you replace your T . Health is a precious commodity, and it should be a priority for you! Life with health is the only way to age…consider replacing your T in the safest way possible— T pellets are my choice, but please replace missing T in any way you can.
9/10/21 Titan Lifestyle with Big Dru & John: - Our social media: https://linktr.ee/TitanMedicalCenter - Live Q&A on @Titanmedical social media! - Optimize your health & build your immune system with Thymosin Alpha 1 (TA1) - This Saturday: St Pete Art & Fashion Runway Show! - Understaffed Dallas restaurant rents robots for $15 a day to serve guests - Facebook debuts $299 'Ray-Ban Stories' smart glasses - Tesla locks down a patent for using laser beams as windshield wipers - FBI releases documents on an attempted murder-for-hire plot against Koby Bryant's rape accuser UPCOMING EVENTS: Sept 18: WCFL 30 Anniversary Show Sept 19: WCFL Hall of Fame Show Oct 13: Tampa International Airport Annual Employee Health & Wellness Event Oct 7: Olympia 2021 in Orlando Oct 23: Tim Gardner's NPC Hurricane Bay Nov 13: Cars & Couture: 11th Annual Collector's Gala Dec 4: Tim Gardner's - NPC Atlantic Coast Our current weekly newsletter: https://conta.cc/2WXQO6h Text: titanmedical to: 22828 to get on our emailing list! Titan podcasts: https://titanmedicallifestylepodcast.fireside.fm bigdru #druborden #therapy #thymosin #livestream #johntsikouris #titan #titanmedical #health #medicalcenter #peptide #aminos #vitamins Click here for our link to the New patient Paperwork to get started with Titan & our full list of social media! https://linktr.ee/TitanMedicalCenter And of course you can call/text anytime for more info: 727-389-3220 or http://titanmedicalcenter.com/ We service NATIONWIDE! Text:titanmedical to:22828 to get on our emailing list About Titan Medical Center: We offer Hormone Replacement Therapy, Medical Weight Loss, Injectable Vitamin & Amino Therapies, Relationship, Bedroom Enhancing Therapies, On-Site or Nationwide Blood Work Testing, Peptide Therapies, In-House IV Therapy, & Primary Care. We are based in Tampa, Florida but YES we service NATIONWIDE! We can help you enhance your life and performance while operating at optimal health levels. We have medical doctors and start with blood work testing to get you on the right track! Some of our therapies are available without blood work testing. Call Titan Medical Center to learn how you can have a healthier, stronger life. We offer telemedicine (via FaceTime or Skype) from the comfort of your own home where you will see a licensed medical provider. Our Titan therapies are doctor prescribed & shipped directly to your doorstep from a licensed US pharmacy!
9/7/21 Titan Talk with John: - Our social media: https://linktr.ee/TitanMedicalCenter - Live Q&A on @Titanmedical social media! - Optimize your health & build your immune system with Thymosin Alpha 1 (TA1) - What is the healthiest fish to eat? The best choices for you and the planet - Dennis Rodman would hit weight room after games, “he was bionic” - This weekend: St.Pete Art & Fashion Week! Titan Weekly Newsletter Poll: Have you watched any of our live stream social media shows? Yes, I've seen them all at least once! - 44% Yes, I've seen Titan Talk Tuesdays at 6pm on social media. - 22% Yes, I've seen Titan Lifestyle on Fridays at 2pm on social media. - 11% No, I've never seen any of them! - 22% UPCOMING EVENTS: Sept 18: WCFL 30 Anniversary Show Sept 19: WCFL Hall of Fame Show Oct 13: Tampa International Airport Annual Employee Health & Wellness Event Oct 7: Olympia 2021 in Orlando Oct 23: Tim Gardner's NPC Hurricane Bay Nov 13: Cars & Couture: 11th Annual Collector's Gala Dec 4: Tim Gardner's - NPC Atlantic Coast Our current weekly newsletter: https://conta.cc/2WXQO6h Text: titanmedical to: 22828 to get on our emailing list! Titan podcasts: https://titanmedicallifestylepodcast.fireside.fm therapy #thymosin #livestream #immunesystem #johntsikouris #titan #titanmedical #health #medicalcenter #peptide #aminos #vitamins Click here for our link to the New patient Paperwork to get started with Titan & our full list of social media! https://linktr.ee/TitanMedicalCenter And of course you can call/text anytime for more info: 727-389-3220 or http://titanmedicalcenter.com/ We service NATIONWIDE! Text:titanmedical to:22828 to get on our emailing list About Titan Medical Center: We offer Hormone Replacement Therapy, Medical Weight Loss, Injectable Vitamin & Amino Therapies, Relationship, Bedroom Enhancing Therapies, On-Site or Nationwide Blood Work Testing, Peptide Therapies, In-House IV Therapy, & Primary Care. We are based in Tampa, Florida but YES we service NATIONWIDE! We can help you enhance your life and performance while operating at optimal health levels. We have medical doctors and start with blood work testing to get you on the right track! Some of our therapies are available without blood work testing. Call Titan Medical Center to learn how you can have a healthier, stronger life. We offer telemedicine (via FaceTime or Skype) from the comfort of your own home where you will see a licensed medical provider. Our Titan therapies are doctor prescribed & shipped directly to your doorstep from a licensed US pharmacy!
In this week's episode, Nathalie chats with Jean-François Tremblay start the conversation with LL37 – a powerful antimicrobial peptide naturally synthesized in humans. They then move on to a new hybrid peptide bringing Thymosin Alpha 1 and LL37 – designed to potentially mitigate the natural cytotoxic effects of LL37. They then move on to the synthetic versions of the bioregulator peptides produced by CanLab and correct a commonly held misconception about proper dosing levels. The good news is that Bioregulators just became a lot more affordable! We then move on to GHK…and much much more! Meet This Week's Guest Jean-Francois Tremblay is the owner of CanLab, a Montreal based company that specializes in synthesizing and manufacturing peptides. Jean-François Tremblay is a regular guest on this podcast. Jean-Francois studied Exercise Physiology, Biochemistry, and Pharmacy at UQAM. He has been researching (in theory and in practice) peptides and SARMS since the 90's and has been studying the theoretical basis of what peptides are and their practical applications in sports performance, anti-aging, and health in general. Episode Sponsor: drinkHRW.com To get the most out of any therapy it is crucial to address the foundations of health. Molecular Hydrogen addresses these foundations through its ability to help to manage reactive oxygen species (ROS), inflammation and improve metabolic balance. I drink molecular hydrogen water every morning before anything else and have my clients do the same. Anecdotally we have seen improvements in blood sugar control, pain from arthritis and even cognitive function in a Parkinson's patient. Ongoing research is demonstrating the many ways that molecular hydrogen can support human health. Use promo code Lonegvity10 to save 10% off your purchase at drinkHRW.com Key Takeaways [03:35] Ll-37 can it possibly play a role in dealing with the current crisis? [07:13] Ll-37 to treat HIV… [08:00] Cytotoxicity (the dying of good cells) with ll-37. How can we mitigate that reaction? [09:08] Vitamin D levels and immunity; genetic variations that inhibit vitamin D conversion [11:23] How does air pollution effect health and natural ll-37 levels? [15:30] Ll-37/TA1 hybrid peptide.. What can it treat? Why does it work? [22:27] Dosing of ll-37/TA1 [28:00] Let's talk bioregulator peptides.. Synthetic vs natural? Oral vs injection? [33:15] Dosing of synthetic vs natural bioregulator peptides [41:00] Is Epitalon an anti-cancer compound? [43:23] Bioregulator peptides and their effects on other organs… [47:30] Thymosin beta 4's use in anti-aging and heart treatment... [51:00] Mots-C for energy and chronic fatigue.. [54:14] GHK and it's effect on genetics, skin and more… What is the best protocol for GHK?.. [60:01] Insulin pumps for peptides?.. Check out https://canlabsciences.com/ and use Promocode OSP15 for your purchase Linkage: Study discussed re Human Cathelicidin (LL37) & Covid19 Insulin Pump DISCLAIMER: This podcast and the information presented are for informational purposes only and not intended to diagnose or treat disease. Before making any changes to your nutrition or supplementation please check with your physician or health provider. Most peptides are classified as research chemicals and are not intended for human use – this podcast in no way is promoting or endorsing the personal use of peptides beyond research purposes.
In this episode, Dr Kent Holtorf and I talk about how he first found peptides and how they have transformed his health and the way he practices medicine. We then discuss the oral peptides available through Integrative peptides TB4Frag for repair and immune support, BPC 157 for repair, KPV for inflammation and CerebroPep for the brain and what’s coming next…. Meet this week’s guest: Kent Holtorf, M.D. is the medical director of the Holtorf Medical Group and a founder and director of the non-profit National Academy of Hypothyroidism (NAH), which is dedicated to the dissemination of new evidence-based information to doctors and patients on the diagnosis and treatment of hypothyroidism and advanced integrative diagnostic and treatment protocols. He has personally trained numerous physicians across the country in the use of bioidentical hormones, hypothyroidism, peptide therapy, stem cell therapy, complex endocrine dysfunction and innovative treatments of chronic fatigue syndrome, weight loss, fibromyalgia, and chronic infectious diseases, including Lyme and related diseases. Lyme and associated diseases have been the focus of the Holtorf Medical Group centers and have been a passion of Dr. Holtorf’s for over 15 years. To try these for yourself: IntegrativePeptides.com use Promo Code Longevity10 to get 10% off Key Takeaways: 2:12 How Dr Holtorf found Integrative Medicine 4:30 His health journey through med school that led to starting National Academy of Hypothyroidism, a nonprofit thyroid association 6:42 How discovering hangover free beer led to the founding of a Beer Company 8:47 Opening up 2 centers, his stressful divorce, experiencing the difficult times 9:50 Then Dr Holtorf found peptides …. Everything changed from there 12:01 In very ill patients peptides can revive the immune system so that fewer antibiotics can get the job done 15:28 When you look at the way the body works, we think of signaling it's kind of like hormones 16:17 BPC puts the body back in homeostasis 17:25 How the thymus peptides restore balance in the immune system 24:38 The link between Autoimmune conditions and infections 26:30 They do initial panel, they can pick out who has these multisystem illness and how bad it is 28:42 Thymosin alpha 1 36:00 KPV - orally bioavailable suppresses mast cells, busts biofilms, anti candida… 39:00 How can BPC be so big a molecule and still be orally bioavailable? The rule of 5.. 42:47 BPC 157 may protect EMF’S through stabilization of cellular calcium channels 48:34 TB4 supports autophagy by supporting mitochondria 50:00 TB4 and cancer - rushing to the rescue? 54:13 CerebroPep - Integrative Peptide’s oral version of Cerebrolysin 59:19 Coming soon: Peptigenic, an analgesic stem cell cream with peptides in it 1:07 Heavy Metals often don’t cause issues till there’s an infection involved Linkage: Dr. Richard Horowitz DNA ConneXions Peptigenic Connect: www.NAHypothyroidism.org www.HoltorfMed.com www.integratedpeptides.com (Use code LONGEVITY10 to get 10% off your purchase) Disclaimer: Please note that this content is intended for information purposes only and is not intended to substitute professional medical advice, diagnosis or treatment. Before changing your diet or using any new supplement make sure to consult with your care provider. Always seek the advice of your physician or care provider with any questions or concerns you may have regarding a medical condition before you make any changes.
Dr. Eric discusses more peptides; this episode is about an amazing healing peptide, Thymosin Beta 4.
Qué hacer para mantenerse y mantener a los demás a salvo de la COVID-19 Guarde al menos 1 metro de distancia entre usted y otras personas, a fin de reducir su riesgo de infección cuando otros tosen, estornudan o hablan. Mantenga una distancia aún mayor entre usted y otras personas en espacios interiores. Cuanto mayor distancia, mejor. Convierta el uso de la mascarilla en una parte normal de su interacción con otras personas. Indicaciones básicas sobre la manera de ponerse la mascarilla: Lávese las manos antes de ponerse la mascarilla, y también antes y después de quitársela. Asegúrese de que le cubre la nariz, la boca y el mentón. Indicaciones específicas sobre el tipo de mascarilla que se ha de usar, y en qué circunstancias, en función de la magnitud de la circulación del virus en el lugar en que usted vive, el lugar al que se dirige y quién es usted. Utilice una mascarilla de tela, a menos que pertenezca usted a un grupo de riesgo determinado. Esto es especialmente importante cuando no pueda mantener la distancia física, en particular en entornos de aglomeraciones y en interiores poco ventilados. Utilice una mascarilla médica/quirúrgica si: Es mayor de 60 años Tiene enfermedades preexistentes, Se siente mal y/o Está cuidando a un miembro de la familia enfermo. Para los profesionales sanitarios, las mascarillas médicas son equipo de protección personal esencial cuando tratan casos sospechosos, probables o confirmados de COVID-19. Las mascarillas autofiltrantes (entre ellas las FFP2, FFP3, N95, N99) se deberán utilizar en los entornos donde se realizan procedimientos generadores de aerosoles, y se deben adecuar para asegurar el uso de la talla correcta. Para obtener más información sobre la manera en que el virus de la COVID-19 infecta a las personas, y sobre la reacción de nuestro organismo.
Thymosin Beta 4 and TB500 - are they one and the same? NO! We are BACK!!! In the peptide world these two peptides are often referred to interchangeably....as if they were one. And yet - they are most certainly not! In this short interview Jean-Francois Tremblay from CanLabs explains how they are related but quite different and how they may work together in certain scenarios. Remember - none of this information is to be used as medical advice ...there is a LOT we do not know about peptides hence peptides are still rated as "research chemicals" so before you even think of using these please consult with a medical professional to assess any risks. 5:00 Amino acids 17-23 6:30 Anti-fibrotic 7:00 Why people interchange TB500 and Thymosin Beta 4 9:00 If you want a tan just take melanotan2 9:10 For sensory effect take this peptide 9:30 If you want more take this peptide 9:50 “Moron proof” peptides 12:30 Neuro benefits of Thymosin Beta 4 14:15 Used for race horses 15:20 Number of peptides in Thymosin Beta 4 chain. 15:45 How to double check names and peptides: check the number 23:00 The math of peptides 23:50 Cost effective 26:00 TB4 pills and the issue of digesting 27:30 How peptides digested work with leaky gut better in the beginning 31:40 BPC-157 is an orally available peptide 32:40 TB500 hones in on musculoskeletal system https://www.canlabresearch.com/ Please note that this content is intended for information purposes only and is not intended to substitute professional medical advice, diagnosis or treatment. Peptides are for the most part classified as research chemicals so should not be used on humans. Before changing your diet or using any new supplement make sure to consult with your health care provider. Always seek the advice of your physician or health care provider with any questions or concerns you may have regarding a medical condition before you make any changes.
Why You Should Listen: In this episode, you will learn about the use of peptide therapies in support of those with chronic illness. About My Guest: My guest for this episode is Dr. William Seeds. William Seeds MD is a board-certified surgeon practicing medicine for over 25 years. He is the Founder and Chairman of the International Peptide Society, Faculty Developer and Lecturer of the A4M Peptide Certification Program, and leading peptide therapy researcher. He is Chief of Surgery and Orthopedic Residency Site Director for University Hospital, Conneaut. He has been honored at the NFL Hall of Fame for his medical expertise in helping professional athletes recover from their severe injuries and has served as Professional Medical Consultant for the NHL, MBL, NBA, and NBC’s Dancing With The Stars. Today, he’s dedicated to bringing his mission to everyone: athletes, mom, entrepreneurs, and everything in between. His mission is simple: help people feel better, operate at the highest functionality in their physical bodies, their brains, their bones, and everything in between without toxic pharmaceuticals or temporary fixes that are inefficient to improve healthspan. Key Takeaways: - What are the potential side effects with peptide therapies? - How might peptides support the body to mitigate the impact of environmental toxins? - Do peptides have a role in mold illness? - What peptides may be helpful for sleep support? - Can peptides help to balance the nervous system or limbic system? - What is the role of peptides in immune modulation? - How might peptides upregulate GI function which has far-reaching, systemic effects? - Can peptides create more lasting energy throughout the day? - Might peptides play a role in cellular hydration? - What peptides may serve to support the body against microbial burdens? Connect With My Guest: http://DrSeeds.com Related Resources: http://Seeds.md http://PeptideSociety.org Interview Date: May 27, 2020 Transcript: To review a transcript of this show, visit http://BetterHealthGuy.com/Episode120 Additional Information: To learn more, visit http://BetterHealthGuy.com. Disclaimer: The content of this show is for informational purposes only and is not intended to diagnose, treat, or cure any illness or medical condition. Nothing in today's discussion is meant to serve as medical advice or as information to facilitate self-treatment. As always, please discuss any potential health-related decisions with your own personal medical authority.
Dr. Michael Moeller, NMD is a gentleman, a doctor, and a scholar of optimizing men's health. He is a naturopathic physician who is the founder of Infinity Medicine and Wellness in Laguna Hills, California. He specializes in peripheral neuropathy regeneration, men's hormones, and men's health. Today on the podcast we talk about growth hormone releasing peptides, growth hormone releasing hormones, and immunity. These peptides govern optimizing lean mass and muscle gains, sleep, immune health, and stimulate your body's recovery. Here are a few of the peptides we speak about: Growth hormone releasing peptides Ipamorelin MK677 Ibutamoren GHRH - Growth Hormone Releasing Hormone Sermorelin Tesamorelin CJC 1295 Body Protecting Compound BPC 157 Immune peptides Thymosin Beta 4 (TB-500) Thymosin Alpha 1 (TA-1) Sexual enhancement Bremelanotide - PT 141 I hope you guys enjoy today's episode! Jump on Youtube and check out more video with Dr. Michael Moeller (Dr. Moe) today. Links: Dr. Moeller's website I https://www.drmichaelmoeller.com/ Four peptides for immune function I Dr. Michael Moeller NMD Dr. Moeller's prolific YouTube channel Dr. Raisanen's healing with peptides - blog post Dr. Raisanen's TRT article
4-17-20:On today’s Titan Lifestyle with Big Dru (broadcast LIVE on Facebook, Instagram & Youtube) Titan Athlete Big Dru & Titan Medical owner John Tsikouris talk about: WWE essential? Curfew, masks what's next? Summer Ready Combo: Titan Fat Burning Cream & ECA Stack Plus: Great Price! Iron Bay Classic Be safe & follow orders *** Titan Coronavirus Package giveaway *** As always we have LIVE Q&A so please comment & ask any questions! See our Titan Medical Health & Lifestyle TV Show Sundays on ABC @11am! Sign up for our Titan Medical Fitness PROGRAMS (nutrition & workouts): titanmedicalfitness.com Don’t miss out on our Titan Weekly Newsletter that’s full of information about Titan’s therapies, events, & just about everything else! It includes direct links to all of our social media and website sections all in one email! 4/13/20 Weekly Newsletter:Peptide Therapy Thymosin Alpha 1 (https://conta.cc/2JWJL4c) Just text: “titanmedical” to the number: 22828 to automatically be put on our emailing list. Follow us on our social media, YouTube, & listen to us on our Titan Medical podcast! (https://titanmedicallifestylepodcast.fireside.fm) titanmedical #bigdru #johntsikouris #peptide #coronavirus #COVID-19 #bodybuilder #muscle #injectablevitamin #anitoxidants #diseaseprevention #medicalscience #aminos #vitaminb12 #preventativemedicine #health #advice #tampa #therapy #medicalclinic #weightloss #diet #talkshow #antiaging #tvshow
4/14/20: On today’s Titan Talk (broadcast live on Facebook, Instagram & Youtube!) Titan Medical Center CEO John Tsikouris answers live Q&A and talks about: Therapy of the Week: Peptide TA1 Thymosin Alpha 1 (Check out the therapy informational video after the show “Peptide Thymosin Alpha 1 informational video by Medical Provider APRN Cass Fernandez” https://youtu.be/dZcV3syexAE) I got a SLAP tear!? We will go over what it is & the best treatments for it. Wearing masks & curfews Do you guys agree with some of the laws taken place? WWE (World Wrestling Entertainment) essential? Obesity & diabetes Blood testing discounts $130 males & females $200 *** Titan Coronavirus Package giveaway *** Weekly Poll: What do you miss the most during this Covid-19 quarantine? Friends & Family Gatherings * Gym * Eating Inside Restaurants * Going To The Movies/Mall * Beach Or Pool * Nothing As always we have LIVE Q&A so please comment & ask any questions! See our Titan Medical Health & Lifestyle TV Show Sundays on ABC @11am! Sign up for our Titan Medical Fitness PROGRAMS (nutrition & workouts): titanmedicalfitness.com Don’t miss out on our Titan Weekly Newsletter that’s full of information about Titan’s therapies, events, & just about everything else! It includes direct links to all of our social media and website sections all in one email! 4/13/20 Weekly Newsletter:Peptide Therapy Thymosin Alpha 1 (https://conta.cc/2JWJL4c) Just text: “titanmedical” to the number: 22828 to automatically be put on our emailing list. Follow us on our social media, YouTube, & listen to us on our Titan Medical podcast! (https://titanmedicallifestylepodcast.fireside.fm) titanmedical #peptide #coronavirus #COVID-19 #ta1 #thymosinalpha1 #bigdru #johntsikouris #bodybuilder #muscle #injectablevitamin #anitoxidants #diseaseprevention #medicalscience #aminos #vitaminb12 #preventativemedicine #health #advice #tampa #therapy #medicalclinic #weightloss #diet #talkshow #antiaging #tvshow
3/6/20: On today’s Titan Lifestyle with Big Dru (broadcast live on Facebook, Instagram & Youtube!) Titan Athlete Big Dru & Titan Medical owner John Tsikouris talk about: Lend a helping hand Titan AOD 9604 Fat Burner for weight loss Beef - for breakfast, lunch & dinner Summer Goals - Call Titan now! Big Dru Lift Party Therapy of the week Thymosin Alpha 1 -Game changer for immune function! Arnold Convention shutdown this year because of Coronavirus (COVID-19) Schools & companies in Seattle working remotely The VapoShower is awesome! Tony Romo is getting $17million a year for 5 years & it’s not for playing football Awesome events coming up! Big Dru Titan Lift Party! - TBD March 7th - Luxe Lingerie Show - Tampa March 13th - World Class Fight League XXVI - Tampa March 14th - Drop Zone Gunner III - Leesburg April 5th - Mad Burger Fest - Madeira Beach May 16th - Tampa Bay Jeep Fest - Clearwater June 20th - Deke Warner’s NPC Mid Florida Classic - Orlando Sept 12th - NPC Iron Bay Classic - Tampa Titan show on ABC in FL, from Sarasota to Crystal River, Sunday’s @11 AM Titan Medical Fitness PROGRAMS (nutrition & workouts) are ready! Don’t miss out on our Titan Weekly Newsletter that’s full of information about Titan’s therapies, events, & just about everything else! It includes direct links to all of our social media and website sections all in one email! 3/2/20 Weekly Newsletter: TA1 (Thymosin Alpha 1) & NEW UPCOMING EVENTS! Email Link https://conta.cc/3are6mR Just text the words: “titanmedical” to the number: 22828 to automatically be put on our emailing list. Follow us on our social media, YouTube, & listen to us on our Titan Medical podcast! (https://titanmedicallifestylepodcast.fireside.fm) titanmedical #coronavirus #COVID-19 #peptides #bodybuilder #muscle #diseaseprevention #medicalscience #aminos #vitaminb12 #preventativemedicine #health #advice #tampa #therapy #medicalclinic #bigdru #johntsikouris #weightloss #diet #talkshow #antiaging #tvshow #free #injectables #ivdrip
3/3/20: On today’s Titan Talk (broadcast live on Facebook, Instagram & Youtube!) Titan Medical Center CEO John Tsikouris talks about: Special Guest Rachel Daniels aka: The Real Lois lane Therapy of the week: Thymosin Alpha 1 - Immune system modulator peptide What it is & how it works. New athletes & ambassadors are coming on! Arnold testing athletes for coronavirus Blood testing amino acids & why? New events coming are going to be awesome & a variety of different things! March 7th- Luxe Lingerie Show March 13th (6-12pm) - World Class Fight League XXVI March 14th (Daytime) - Drop Zone Gunner III April 5th (10am-4pm) Mad Burger Fest - Madeira Beach May 16th (12-5pm) Tampa Bay Jeep Fest- Clearwater June 20th (9am) - Deke Warner’s NPC Mid Florida Classic St.Pete Art & Fashion Week 10-12th Sept 12th (9am-9pm) NPC Iron Bay Classic Titan TV Show on ABC in Florida from Sarasota to Crystal River. Tune in Sunday’s 11 AM! Titan Programs are ready: titanmedicalfitness.com Poll question: Have you done any preparation for the Coronavirus? CHOICES: “Yes”, “No”, “Why should I?” & “I don't know what the Coronavirus is” Don’t miss out on our Titan Weekly Newsletter that’s full of information about Titan’s therapies, events, & just about everything else! It includes direct links to all of our social media and website sections all in one email! 3/2/20 Weekly Newsletter: TA1 (Thymosin Alpha 1) & NEW UPCOMING EVENTS! Email Link https://conta.cc/3are6mR Just text the words: “titanmedical” to the number: 22828 to automatically be put on our emailing list. Follow us on our social media, YouTube, & listen to us on our Titan Medical podcast! (https://titanmedicallifestylepodcast.fireside.fm) Don’t forget to join us on Friday when we go live with Titan Athlete Big Dru! titanmedical #coronavirus #arnold #peptide #fitness #enhancement #medicalscience #health #aminos #tampa #therapy #medicalclinic #johntsikouris #weightloss #diet #talkshow #injectable b12 #antiaging #tvshow
2/28/20: On today’s Titan Lifestyle with Big Dru (broadcast live on Facebook, Instagram & Youtube!) Titan Medical owner John Tsikouris covers for Big Dru who’s out sick and talks about: Coronavirus preparation! Some tips & tricks to help not catch it. What therapies do we have to combat sickness? Glutathione, Nectar of the Gods, TA1 (Thymosin Alpha 1), & TB-500 Movie of the week: Invisible man Show of the week: Hunters Awesome events coming up! Big Dru Titan Lift Party! - TBD March 7th - Luxe Lingerie Show - Tampa March 13th - World Class Fight League XXVI - Tampa March 14th - Drop Zone Gunner III - Leesburg April 5th - Mad Burger Fest - Madeira Beach May 16th - Tampa Bay Jeep Fest - Clearwater June 20th - Deke Warner’s NPC Mid Florida Classic - Orlando Sept 12th - NPC Iron Bay Classic - Tampa Titan show on ABC in FL, from Sarasota to Crystal River, Sunday’s @11 AM Titan Medical Fitness PROGRAMS (nutrition & workouts) are ready! Here’s our link to this week’s Titan Newsletter: 2/24/20 Weekly Newsletter: John's Birthday Recap & Nectar of the Gods Therapy! Email Link https://conta.cc/2VkLPK8 Don’t miss out on our Titan Weekly Newsletter that’s full of information about Titan’s therapies, events, & just about everything else! To be put on our weekly emailing list automatically just text the word “titanmedal” to the number: 22828 It includes direct links to all of our social media & website sections all in one email! Follow us on our social media, YouTube, & listen to us on our Titan Medical podcast! (https://titanmedicallifestylepodcast.fireside.fm) titanmedical #peptides #diseaseprevention #medicalscience #aminos #vitaminb12 #preventativemedicine #health #advice #tampa #therapy #medicalclinic #johntsikouris #bigdru #weightloss #diet #talkshow #antiaging #tvshow #free #glutathione #injectables #ivdrip
11/5/19: On today’s Titan Talk (broadcast live on Facebook, Instagram & Youtube!) Titan Medical Center CEO John Tsikouris goes over: *** New feature for our Titan Live shows:Our Titan Weekly Newsletter Code Word Giveaway! Go to our newsletter and pick the code word John gives during this live to win! Here is the Weekly Titan Newsletter Direct Link to this week’s newsletter: https://conta.cc/2Nd0i6w *** Therapy of the Week: Thymosin Alpha1! -What is it? -How does it work? -Peptide & modulator of immunity & inflammation -28 amino acid peptide -Protects from oxidative damage -Enhances immune function -Increase T cells killer & helper -Helps with chemo patients with suppressed immune systems *** TOPICS: -Training yourself to eat better -NEW TITAN LOCATION in Tampa! -What we do here at Titan *** Weekly Titan Newsletter Poll question: How do you get in your daily activity? - Going for walks/runs? - Going to the gym/home workouts? - In the bedroom - None of the above ***Each show: Q&A - Events - Titan gear giveaway #titangear Follow us on our social media, YouTube, and listen to us on our Titan Medical podcast! Don’t forget to join us on Friday when we go live with Titan Athlete Big Dru! #titanmedical #medicalscience #health #advice #tampa #therapy #medicalclinic #johntsikouris Titan Medical Center CEO John Tsikouris goes live on his Instagram and Facebook video feeds every Tuesday at 6pm (Titan Talk Tuesdays) and talks to his viewers and answers questions about health, fitness and medical science. We air the episodes here as soon as they're finished for your listening convenience.
The Pep Talk: Thymosin Beta 4 Reviewed - Dr. Carl Paige, MD - Thymosin Beta 4 also known as TB-500 made its debut in the thoroughbred race horse industry. Quickly adopted by athletes, many misconceptions about what it does or doesn't do in humans have followed. Dr. Paige gets to the truth.
The Pep Talk: Thymosin Beta 4 Reviewed - Dr. Carl Paige, MD - Thymosin Beta 4 also known as TB-500 made its debut in the thoroughbred race horse industry. Quickly adopted by athletes, many misconceptions about what it does or doesn't do in humans have followed. Dr. Paige gets to the truth.
is one of the smartest, most cutting-edge physicians I've ever met, and this is part 2 of my amazing two-part interview with him, recorded from my home in Spokane, WA. You can listen to part 1 at "" During that first episode we discussed: ...how he's used the nootropic methylene blue to solve a difficult medical case... ...how he's upgrading stem cells to make them far more potent... ...how he's treating depression effectively in as little as 20 minutes with a special brew that includes ketamine, NAD and vitamin IVs... ...how he's reversing musculoskeletal disorders using something called "hydrodissection"... Dr. Cook founded BioReset Medical Corporation and as acting President, operates a Regenerative Medicine and Pain Medicine practice that offers leading-edge non-surgical solutions in orthopedic medicine, sports medicine, regenerative pain medicine, and stem cell medicine. He is a board-certified anesthesiologist with over 20 years of experience in medical practice. Currently, Dr. Cook is President of California Anesthesia and Medical Director of the National Surgery Center, Los Gatos, CA. In addition, he sits on the scientific advisory board of several high profile medical companies including BM DOC, FREMEDICA & VASPER SYSTEMS. Dr. Cook’s early career as an anesthesiologist and medical director of an outpatient surgery center that specializes in sports medicine and orthopedic procedures provided invaluable training in the skills that are needed to become a leader in the emerging fields of Musculoskeletal Ultrasound imaging, nerve hydrodissection, and stem cell medicine. During this Part 2 discussion, you'll discover: -Dr. Cook's Opinion on the use of beta blockers in preparing for performance...9:30 Gave a talk to over 2,000 doctors early in his career Was given a beta blocker by an associate; Heart rate went down to 25 bpm. Never taken another beta blocker since. Sweet spot for everything. Biohacking too high or too low is problematic Has used beta blockers with anesthesia to calm the heart rate. -Plasmapheresis, what Dr. Cook's considers to be one of the "next big things" in the medical industry...11:58 Plasmapheresis A method of removing blood plasma from the body by withdrawing blood, separating it into plasma and cells, and transfusing the cells back into the bloodstream. It is performed especially to remove antibodies in treating autoimmune conditions. It has also been studied as a treatment for neurocognitive and Neuro degenerative problems like Alzheimer’s and Parkinson’s disease. It’s kind of like an oil change in your vehicle. If there is systemic inflammation, often that inflammation is in the plasma of the blood. Different from parabiosis Same procedure as Dr. Mark Urdahl and I discussed on the podcast a few months ago. (Listen to the episode .) Most people who seek plasmapheresis have a serious conditions like Lyme, dementia, Parkinsons, etc. Effect on a healthy person: No negative effect. Nothing wrong with a thorough examination Length of the procedure: 2-3 hours, 1x/week for 6 weeks. -Dr. Cook's thoughts on the use of cannabinoids in his practice...18:50 We have cannabinoid receptors in our brains. Part of our nervous system is called the endocannabinoid system. Expect a surge of use in the next 10 years among health optimizers and chronically ill people. "Entourage effect" Unicorn: a company that is purifying cannabinoids and get all the solvents out Delta 8 THC vs. Delta 9. Rick Simpson Oil: highly potent What are terpines? The terpines are the flavor the smell and much of the effect. The effect of sativa or the effect of the indica is from the terpines in that strain. Can be up to 100 terpines in a strainCan also control flavonoids.... Unicorn can make them bioavailability We are going to be studying these blends Do you give a f*ck? Here's how to follow what's up with the Unicorn brand: -Dr. Cook's approach to dealing with gut issues...31:40 Get a sense of symptoms Test for parasites, the microbiome, stool sample Food goes through the stomach, to small intestine. Small intestine is sterile Goes into large intestine, trillions of bacteria Parasites live in the small intestine SIBO: small intestinal bacterial overgrowth (Listen to my podcast with Dr. Michael Ruscio ) Anti-inflammatory diets Collagen, bone broth, colostrum is efficacious in healing the gut. Everything is fixable. "Bio Reset" -What Dr. Cook likes and uses in his practice with peptides...43:55 Peptide is a smaller version of a protein BPC 157 used in combination with stem cells and treating GI problems TB 500 Thymosin used for chronic infections Peptides becoming common for treatment of chronic illnesses Immune over response and under response - Immune modulation Nootropic peptides: Seamax, Sealance -What is "hyperthermia"?...51:22 Used for treating chronic infections and cancer. Two options under consideration: High tech sauna Venovenus Malarial treatment: German doctor discovered a way to cure malaria using hyperthermia in the 1920's after WWI. -Dr. Cook's approach to treating Lyme disease...59:17 Similar approach as to the gut. Tick-borne illness Effects similar to syphilis Step back, get broadest possible level. Full assessment food allergies pain in joints Neural lyme What modalities have been successful? Ozone Ketamine NAD Peptides Regenerative medicines: exosomes and stem cells (Listen to my podcast with Dr. Harry Adelson ) -How Dr. Cook teaches other doctors in these practices...1:09:00 -And much more! Resources from this episode: Part 1: -Young Blood Institute podcast -Dr. Michael Ruscio podcast -The Swiss Detox Retreat Ben is leading in summer 2019 -Book - -Podcast with Dr. Harry Adelson Episode Sponsors: - Learn The Most Popular Fasts, How To Do Them, And How They Can Boost Your Health. Get my free guide, Fasting Decoded, get in on all the goodness at - delivers quality nutrition to the world with delicious, easy-to-mix superfood drinks. Hundreds of thousands of women and men use Organifi products to sleep better, get their energy back and achieve their weight loss goals. Use code "Greenfield" at checkout and receive 20% off your entire purchase! - Unlock the power of gratitude. When you introduce conscious, mindful gratitude into your day, positivity will begin to pour into your life – along with all the other scientifically proven physical, mental and spiritual benefits you’re about to discover. Get 20% off your order with coupon code "grateful2019" when you purchase 2 or more journals! - is increasing the prices on their saunas next month. So if you've been thinking of getting one, now's the time. Use coupon code "bengreenfield" and get the original pricing, plus free shipping within the U.S. Do you have questions, thoughts or feedback for Dr. Cook or me? Leave your comments at http://bengreenfieldfitness.com/bioreset2 and one of us will reply!
Peptides are a grouping of 50 or fewer amino acids (more than 50 is a protein). Peptides are natural substances, though those covered in the show are variations on the naturally occurring versions. They can be beneficial in many ways, often amplifying the body’s ability to heal itself. They discuss the history of the use of peptides in a medical environment, as well as the future of peptides becoming available commercially in the U.S., with over 7,000 in clinical development currently. Cancer research is one of the leading development areas for peptides (ALRN-6924 is one of the prominent ones studied). Antimicrobial research is also being done to potentially create new antibiotics. There are different methods of delivering peptides to the body. They are not very bioavailable orally and are prone to hydrolysis, so injection is the best for the majority of peptides. They explore some of the benefits of peptides over traditional medications, such as allergic reaction is limited with peptides, and neither the kidneys nor liver have to process them like traditional medications require. They also consider the potential side effects of using peptides. They warn against purchasing peptides from online companies, as many of them are produced overseas in bulk without any regulation, often not containing what they claim. The only safe way to get access to peptides is through a reputable doctor who practices integrative medicine, with access to compounding pharmacies like Tailor Made Compounding. Some of the peptides covered on the show: Human growth hormone (HGH) secretagogues like Ipamorelin, CJC-1295, Sermorelin and Tesamorelin encourage the pituitary gland to increase HGH production. They also explain the significant risks of using human growth hormone therapy directly. GLP-1 and Semaglutide could be used for diabetes treatment. Melanotan 2 stimulates melanocytes to produce melanin, causing a tanned appearance of the skin. Epitalon resets the HPA (hypothalamic-pituitary-adrenal) axis, with a number of potential positive effects on disease states, possibly helping to lengthen or preserve the length of telomeres, increases melatonin for better sleep and more. BPC-157 is orally bioavailable, unlike most peptides, with a variety of reported benefits. This includes helping with neural inflammation, muscle improvement, improved immunity, improved collagen synthesis, increased bone density and accelerated recovery/healing. It is most often used clinically to treat gut and bowel issues and tendon and ligament repair. Thymosin beta-4 is beneficial for soft tissue injury by increasing blood flow to the area, encouraging healing. Thymosin alpha 1 is FDA approved (commercially available as ZADAXIN™ for treatment of viral hepatitis), encouraging increased immune response to some cancers, Lyme disease and sexually transmitted diseases. PT-141 has a benefit for treating some erectile dysfunction and female sexual dysfunction. Follistatin (actually a protein, not a peptide) has the potential to inhibit myostatin, which prevents muscle breakdown. Cerebrolysin is a combination of peptides with potential useful for brain repair in neurodegenerative conditions such as Alzheimer’s, Parkinson’s and strokes. Selank and Semax are Russian peptides that are nasally bioavailable that have been reported to help with anxiety. MIF-1, ACTH, Dihexa have limited research but have been considered to help with depression, bipolar disorder and PTSD. IGF1 has nerve regenerative capabilities. GDF11 may be beneficial in tissue repair, so useful in anti-aging, but with potential health drawbacks. About the guest: Ryan Smith attended Transylvania University and double majored in Philosophy and Biochemistry. In that time, he had multiple research internships at the University of Kentucky and University of Pennsylvania, studying large scale protein synthesis and physical chemistry. After graduation, he attended medical school at the University of Kentucky for 2 years. After finishing all the educational curriculum and passing USMLE Step 1, he decided to leave and help open up a pharmacy in the United States that focuses on peptide synthesis and formulations for pharmaceutical preparations. Since that time, Tailor Made Compoundinghas become licensed in over 45 states and territories, including Dubai, and has become the leader in the compounding of peptides and proteins for pharmaceutical use. Follow Tailor Made Compounding on Facebook @TailorMadeCompounding and Twitter @TMCompounding.
Peptides aren’t just the new trendy thing in health. They are vital for addressing so many conditions and diseases. What are some of the many different health concerns it can be applied to? Why is selectivity so important if you’re using peptides in the long-term? What are the best peptides for building muscle? On this episode, we talk to VP of Business Development at Tailor Made Compounding, Ryan Smith, to go deep on peptides and their applications. Three Takeaways The people who hold the money in the sick care model are not the doctors or the patients-- it’s third-party payers and insurance companies. The only people who benefit from SARMs are people selling it underground. Falstatin for human therapy is tricky because it hasn’t been thoroughly tested. Thymosin beta-4 and BPC are repair and recovery products that athletes should be able to use. At the start, Ryan shared how he got started in the industry, and we talked about the problems with the sick care model. We then discussed the strengths and benefits of peptides, muscle-building peptides, and dealing with hypertrophy. Toward the end, we discussed Cerebrolysin for anxiety, opiate-withdrawal and pain management. We also covered: Using tesamorelin and ipamorelin Whether SARMs are really worth it How peptides can benefit injured athletes The sick care model has completely failed. People get worse, become dependent on drugs, and never get healthy. This is what’s driving the interest and use of peptides. They are the future of medicine because of just how many health and optimization problems they can solve. Peptides are great because they don’t have many side effects from a metabolizing standpoint, and you don’t have to worry about drug interactions. Guest Bio- Ryan is the VP of Business Development at Tailor Made Compounding. Go to https://tailormadecompounding.com/ for more information.
Medizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 16/19
Thu, 20 Feb 2014 12:00:00 +0100 https://edoc.ub.uni-muenchen.de/18100/ https://edoc.ub.uni-muenchen.de/18100/1/Trenkwalder_Teresa.pdf Trenkwalder, Teresa Margarita ddc:610, ddc:600, Medizinische Fakultät
Tierärztliche Fakultät - Digitale Hochschulschriften der LMU - Teil 04/07
Der akute Myokardinfarkt stellt in den Industrienationen immer noch eine der häufigsten Todesursachen dar. Auch nach Wiedereröffnen des Gefäßes führt eine prolongierte myokardiale Ischämie zur Ausbildung eines Infarktareals. Neben der irreversiblen Schädigung der Myozyten während der Ischämie kommt es auch zu dem so genannten Reperfusionsschaden, dieser kann aber, zumindest tierexperimentell, durch eine entsprechende Therapie verringert werden. Wir konnten bereits zeigen, dass die retrograde Applikation von embryonalen endothelialen Vorläuferzellen, von murinen Embryonen Tag 7,5 (Tie-2+, c-Kit+, Sca-1+, flk-1 low, MHC-1-) eine Kardioprotektion über lösliche Faktoren vermittelt. Diese Reduktion der Infarktgöße war über einen PI3K-AKT Signaltransduktionsweg vermittet. In der hier vorliegenden Studie haben wir uns mit dem Einfluss von Thymosin β4 auf die eEPC vermittelte Kardioprotektion beschäftigt. Methoden: In vitro wurden neonatale ventrikuläre Myozyten der Ratte einer Hypoxie (4 h) und Reoxygenation (1 h) ausgesetzt. Die überlebenden Zellen wurden mittels Trypan-Blau-Exklusion identifiziert. Des Weiteren wurden neonatale ventrikuläre Endothelzellen der Ratte auch einer Hypoxie (18 h) und Reoxygenation (4 h) ausgesetzt und die Apoptoserate mittles TUNEL-Färbung analysiert. Embryonale EPCs mit/ohne Thymosin β4 shRNA Transfektion wurden während Hypoxie kokultiviert oder Thymosin β4 Protein wurde dem Medium zugesetzt. In Schweinen (n= 9 pro Gruppe) wurde am Tag 1 mittels LAD-Verschluß (1 h) ein Infarkt induziert. 5x106 eEPCs mit/ohne Thymosin β4 shRNA Transfektion oder Thymosin β4 Protein wurden nach 55 min Ischämie in die anteriore interventrikulare Herzvene retroinfundiert. Nach 24 h Reperfusion wurden die globale und regionale Myokardfunktion (Sonomikrometrie) sowie die Infarktgröße bestimmt. Darüber hinaus wurde die Inflammation mittels Myeloperoxidase Analyse im Gewebe untersucht. Ergebnisse: Die „short hairpin“ Ribonukleinsäure (shRNA) Transfektion führte zu einer verringerten Thymosin „messanger“ RNA Expression in „real time“ Polimerase Kettenreaktions-Untersuchungen (rt-PCR). In Zellkultur war der Anteil überlebender neonataler Kardiomyozyten in Anwesenheit von eEPCs signifikant erhöht, wenn diese Zellen Thymosin β4 exprimierten. Die Analyse der TUNEL-Färbung zeigte eine deutlich geringere Apoptoserate der neonatalen Endothelzellen, die mit eEPCs kokultiviert wurden, es sei denn die Thymosin β4 Expression wurde durch Transfektion der shRNA reduziert. Die Applikation von Thymosin β4 Protein zeigte bei beiden Zellarten ein ähnliches Ergebnis wie die Kokultivierung mit den eEPCs. In vivo waren nach 24 h zahlreiche Zellen im ischämischen Areal nachweisbar. Die Anzahl der Zellen war durch die Reduktion der Thymosin β4 Expression nicht beeinträchtigt. Die regionale Applikation der eEPCs reduzierte die Infarktgröße signifikant gegenüber der Kontrollgruppe, wohingegen die Thymosin β4 shRNA Transfektion der eEPCs diesen Effekt inhibierte. Auch hier zeigte die retrograde Applikation des Thymosin β4 Proteins eine kardioprotektive Wirkung, die ähnlich ausgeprägt war wie die der eEPCs. Die Analyse der TUNEL-positiven Zellen zeigte eine deutliche Reduktion der Apoptoserate nach Retroinfusion der eEPCs oder des Thymosin β4 Protein, auch hier verloren die eEPCs ihre protektiven Eigenschaften nach der Transfektion mit Thymosin β4 shRNA. Die Inflammation im Ischämieareal, ein wichtiges Kennzeichen für die Ausprägung des Ischämie/Reperfusionsschadens, konnte durch die Verabreichung von eEPCs und auch Thymosin β4 Protein signifikant reduziert werden. Die Reduktion der Thymosin β4 Expression verhinderte wiederum diesen kardioprotektiven Effekt. Diese Untersuchungen zeigen, dass embryonale endotheliale Vorläuferzellen den Ischämie/Reperfusionsschaden zu einem frühen postischämischen Zeitpunkt verringern. Der kardioprotektive Effekt dieser Zellen ist zumindest teilweise Thymosin β4 abhängig, da eine analoge Protektion durch die lokale Applikation von Thymosin β4 Protein erreicht werden kann. Generell zeigt diese Arbeit, dass neben dem direkten Einsatz von Vorläuferzellen und Stammzellen zur Behandlung des Reperfusionsschadens diese Zellen auch genutzt werden können, um mögliche Kandidatenproteine zur Kardioprotektion nach akutem Myokardinfarkt zu identifizieren und somit eine effektive Therapie des Reperfusions-schadens beim Menschen zu ermöglichen.
Medizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 09/19
Der akute Myokardinfarkt ist eine der häufigsten Diagnosen in den industrialisierten Ländern. In der Regel kommt es zu einem thrombotischen Verschluss einer Koro-nararterie. Die rasche Revaskularisierung und die dadurch erhoffte Reduktion des in-farzierten Areals ist die wichtigste therapeutische Maßnahme zur Rettung des ischämischen Myokards und zur Senkung der Morbidität und Mortalität. Nach der plötzlichen Reperfusion des postischämischen Gewebes kommt es zu einem soge-nannten myokardialen Ischämie/Reperfusionsschaden, der sich als Endothel- und Myozytenschädigung ausbildet. Folge von rascher Reoxygenierung sind u. a. eine gesteigerte inflammatorische Re-aktion und in diesem Rahmen eine gesteigerte Einwanderung von Leukozyten in das ischämische Areal. Die Rolle der Thrombozyten für die postischämische Leukozyten-rekrutierung war bisher unklar. In unserer Studie wurden Wildtyp- (WT), P-Selektin- und ICAM-1/P-Selektin-defiziente Mäuse einer 20-minütigen LAD-Okklusion unterzogen, gefolgt von 15 Mi-nuten Reperfusion, um den Effekt der Interaktion zwischen Endothel, Leukozyten und Thrombozyten und den Einfluss auf den frühen Reperfusionsschaden zu unter-suchen. Anschließend wurden die Herzen ex vivo fluoreszenzmikroskopisch bzw. mittels LV-Druckmessung im isolierten Herzen analysiert. Zur Analyse der Zell-Zell-Interaktion wurden zu Beginn der Reperfusion zirkulierende Leukozyten mit Rhoda-min G6 gefärbt bzw. 2x108 BCECF-AM- oder Rhodamin G6-gefärbte homologe oder heterologe Thrombozyten systemisch infundiert. In P-Selektin-defizienten Tieren war die Verminderung der Leukozytenrekrutierung (Abb. 11) und die Bildung der Leukozyten/Thrombozyten-Co-Aggregate (Abb. 12 sowie die Reduktion des postischämischen linksventrikulären Funktionsverlustes (Tabelle 5) moderat. Dieser Effekt wurde durch die zusätzliche Abwesenheit von ICAM-1 verstärkt (Abb. 11, Abb. 12, Tabelle 5). Die Adhäsion von Plättchen war nicht beeinflusst (Abb. 13). Die Inhibition der Thrombozytenadhäsion mittels Tirofiban, ei-nem GPIIb/IIIa-Inhibitor (Abb. 14), reduzierte die Leukozytenadhäsion und die links-ventrikuläre Dysfunktion (Abb. 15, Tabelle 5). Während in ICAM-1/P-Selektin-defizienten Herzen die direkte Rekrutierung von Leukozyten stark eingeschränkt war, konnte diese durch die Infusion von Wildtyp-Plättchen nahezu vollständig wiederher-gestellt werden. Die Inhibition der Plättchenadhäsion durch die zusätzliche Gabe von Tirofiban konnte diesen Effekt wieder aufheben (Abb. 19). Unsere Experimente de-monstrieren erstmals die Rolle des thrombozytären P-Selektins und des ß3-Integrins GPIIb/IIIa als redundanten Rekrutierungsmechanismus für die thrombozyten-vermittelte postischämische Leukozytenrekrutierung in vivo. Über diesen redundanten Mechanismus tragen Thrombozyten indirekt zum Reperfu-sionsschaden bei, indem sie die postischämische Leukozytenadhäsion verstärken. Diese thrombozyten-vermittelte Leukozytenadhäsion benötigt P-Selektin-suffiziente Plättchen, nicht jedoch endotheliales P-Selektin. Die Antagonisierung von GPIIb/IIIa, die in Patienten effektiv ist für die Thrombolysehandlung31, PTCA177 und Stent-Implantation10, 149, 203, inhibiert sowohl die Plättchenadhäsion als auch thrombozyten-vermittelte Leukozytenrekrutierung. Im experimentellen Modell der akuten myokardialen Ischämie und Reperfusion zeigte die GPIIb/IIIa-Antagonisierung eine protektive Wirkung über die Plättchen-Inhibition hinaus, in dem sie den durch plättchen-vermittelte Leukozytenrekrutierung induzier-ten akuten Reperfusionsschaden reduzierte. In einem weiteren Schritt wurde ein chronisches Mausmodell der myokardialen Ischämie und Reperfusion etabliert, um die Auswirkungen einer reduzierten Leukozy-tenadhäsion auf den chronischen postischämischen Reperfusionsschaden zu unter-suchen und mit alternativen Behandlungsmethoden zu vergleichen. WT-Tiere und ICAM-1-defiziente Tiere wurden einer einstündigen LAD-Okklusion unterzogen, ge-folgt von 14 Tagen Reperfusion. Anschließend wurde die linksventrikuläre Funktion mittels invasiver Millar-Tip Kathetermessung analysiert. 24 Stunden nach Ischämie wurden 3*106 in vitro expandierte embryonale EPC (eEPC) systemisch in WT-Tiere oder ICAM-1-defiziente Tiere infundiert. In zwei weiteren WT-Gruppen wurden auto-loge Progenitorzellen und mononukleäre Zellen aus dem Knochenmark mobilisiert mittels Gabe von 0,5µg GM-CSF 7 Tage vor Ischämie bzw. direkt postischämisch. In den ICAM-1-defizienten Tieren war der postischämische Funktionsverlust im Ver-gleich zu den WT-Kontrollen etwa im gleichen Maß verringert wie bei den eEPC-behandelten Tieren (Abb. 22 Abb. 23, Abb. 24). Unter reduzierter Leukozytenredukti-on in den ICAM-1-defizienten Tieren zeigte sich ein zusätzlicher benefizieller Effekt durch die Behandlung mit eEPCs (Abb. 22 Abb. 23, Abb. 24). DiI-markierte eEPCs konnten histologisch im Infarkt-Areal in enger Nachbarschaft mit Blutgefäßen nach-gewiesen werden (Abb. 28). Die Adhäsion von Leukozyten und der damit verbundene leukozyten-assozierte Re-perfusionsschaden ist durch die Defizienz von ICAM-1 auch im chronischen Ischä-mie/Reperfusionsmodell vermindert. Embryonale EPCs sind in der Lage in ischämisches Areal einzuwandern, zu inkorpo-rieren und protektiv auf die postischämische Funktion zu wirken. Sie können so über einen längeren Zeitraum als Quelle für parakrine, angiogenese-fördernde, humorale Aktivatoren wie z. B. Thymosin-ß4 den Remodellingprozess unterstützen und führen somit zu einer verbesserten postischämischen Funktion. Die Adhäsion von embryonalen EPCs scheint dagegen unabhängig von ICAM-1 zu sein. Hier spielen Selektine211, 1-Integrine57, 141 und indirekt auch Thrombozyten118 eine wesentliche Rolle. Die präischämische Mobilisation von hämatopoetischen Progenitorzellen aus dem Knochenmark mittels GM-CSF hatte in unserem Modell eine vergleichbar protektive Wirkung wie die eEPC-Behandlung oder die Antagonisierung der Leukozytenadhäsi-on durch ICAM-1-Defizienz, während die postischämische Applikation den posti-schämischen Funktionsverlust nicht verbesserte (Abb. 25, Abb. 26, Abb. 27). Die Zytokin-Applikation zeigte bei rechtzeitiger Applikation vor Beginn der Ischämie eine protektive Wirkung. Dieses Protokoll ist allerdings nicht in der Klinik anwendbar. In weiteren Studien wird es notwendig sein, den optimalen Zeitpunkt und die optima-le Dosis zu evaluieren und mögliche Co-Applikation, z. B. Stromal-Cell-Derived-Factor-1, zur Verbesserung der Rekrutierung und zur Effizienzsteigerung zu untersu-chen, um knochenmark-stimulierende Zytokine als erfolgversprechende Behand-lungsalternativen im akuten Koronarsyndrom am Menschen einsetzen zu können.
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