Podcasts about Cortisol

What goes on at the neurobiological level that makes someone more vulnerable to self-injure or self-harm? What biological risk factors are at play? What roles do the vagus nerve, cortisol levels, and hypothalamic-pituitary-adrenal (HPA) axis have? We hope to discuss the psychology of self-injury pain in a future episode, but in this episode, Dr. Michael Kaess from the University of Bern in Switzerland explains the neurobiology of self-injury in simple terms, or what we hope can be considered simple layman's terms.  Learn more about Dr. Kaess and his research team at the Universitäre Psychiatrische Dienste (UPD) in Bern here. To participate in Dr. Kaess' research study of an online intervention for self-injury (in German), visit the STAR (Self-injury Treatment Assessment Recovery) Project at https://star-projekt.de/. Below are links to some of the research referenced in this episode: Kaess, M., Hooley, J. M., Klimes-Dougan, B., Koenig, J., Plener, P. L., Reichl, C., Robinson, K., Schmahl, C., Sicorello, M., Schreiner, M. W., & Cullen, K. R. (2021). Advancing a temporal framework for understanding the biology of nonsuicidal self-injury: An expert review. Neuroscience and Biobehavioral Reviews, 130, 228-239. Reichl, C., Heyer, A., Brunner, R., Parzer, P., Völker, J. M., Resch, R., & Kaess, M. (2016). Hypothalamic-pituitary-adrenal axis, childhood adversity and adolescent nonsuicidal self-injury. Psychoneuroendocrinology, 74, 203-211. Plener, P. L., Bubalo, N., Fladung, A. K., Ludolph, A. G., & Lulé, D. (2012). Prone to excitement: Adolescent females with non-suicidal self-injury (NSSI) show altered cortical pattern to emotional and NSS-related material. Psychiatry Research, 203(2-3), 146-152. Follow Dr. Westers on Instagram @DocWesters. To join ISSS, visit itriples.org and follow ISSS on Facebook and X/Twitter (@ITripleS). The Psychology of Self-Injury podcast has been rated #5 by Feedspot in their "Best 20 Clinical Psychology Podcasts" and by Welp Magazine in their "20 Best Injury Podcasts."

Myoscience micronized creatine monohydrate (20% off, code auto-applied):https://bit.ly/3SoIZn8  Pre-order Keto Flex Revised and get free bonuses at: https://bit.ly/4wKG1sM    Most people think belly fat comes from what they eat. The truth is that the first 60 minutes after you wake up may matter more than anything on your plate. Before a single bite of food, one normal morning habit can spike cortisol, raise insulin resistance, and quietly switch your body into fat storage mode. In this episode I break down the seven morning mistakes that tell your body to hold on to belly fat, including one that is considered healthy and one your favorite wellness influencers recommend. Then I give you the exact first-hour routine I use to flip that switch in your favor, step by step. None of it is about calories, junk food, or willpower. It is about the signals you send before the day even starts. Key takeaways: A natural cortisol rise happens 30 to 45 minutes after waking. Grabbing your phone stacks artificial stress on top of it. Cortisol receptor sites are roughly tripled in visceral belly fat, the "cortisol belly." Water with minerals before coffee, and delaying caffeine about 90 minutes, gives you steadier all-day energy. Morning sunlight in your eyes sets the clock that controls your insulin sensitivity. Protein first at your first meal lowered craving signals in the brain in a University of Missouri study. A short walk after eating clears blood sugar through an insulin-free side door. Survival mode and fat burning mode cannot coexist, so a calm nervous system is part of the plan. Find All The Ben Azadi Show Sponsorship Deals ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.ketokamp.com/sponsorship-deals Learn more about your ad choices. Visit megaphone.fm/adchoices

Episode Highlights With NinuWhat the gut hormone connection is and why it matter so muchHow supporting the gut supports hormones and can improve cortisol and sex hormonesWhy most women are chronically constipated and how to remedy thisWhy high cortisol is a good thing at the right time of day and why it's more about balanceHow screens disrupt melatonin and sabotage sleepThe inputs we need for balanced hormones: sugar stability, nourishment from food, light exposure, movement, and avoiding toxinsHow metabolic resistance is the real driver behind so many health problemsResources MentionedWomen's High Vibe Health to book a free callHigh Vibe Health functional programLMNTI talk often about the health benefits of salt and electrolytes and I am a big fan of LMNT canned drinks and packets. Go to drinklmnt.com/wellnessmana for a special offer.Just Thrive:Just Thrive Health has been one of my longtime favorite brands for gut health and they have an amazing Daily Gut Detox. Your immune system, gut barrier, and digestion get the support they need to stay strong and healthy. You can find this and their probiotics at justthrivehealth.com/wellnessmama or use code wellnessmama for 20% off your order. 

In this fascinating episode, Dr. Scott Watier and Tommy Welling reveal why willpower is not a fixed personality trait but a biological state shaped by your morning cortisol response, circadian rhythm, and light exposure — and how understanding this changes everything about your fasting consistency. They break down the science behind why so many fasters cruise through the day only to find themselves standing in the pantry at night, and why the fix starts in the first 60 minutes after waking. The hosts walk through practical morning anchors — consistent wake times, outdoor morning light, early low-intensity movement, delayed caffeine, and protein-forward earlier meals — that prime the brain's decision-making center to stay strong when ghrelin peaks and temptation hits later in the day. They also tackle the evening danger zone, explaining how blue light exposure quietly shifts your risk-reward thinking and erodes the prefrontal control you built all day, making light discipline and a closed kitchen ritual non-negotiable tools for fasting success. This week's challenge is simple: pick one morning lever and one evening guardrail, stack them consistently, and watch how much easier it becomes to close your fasting window and wake up with a win. ⁠Take the NEW FASTING PERSONA QUIZ! - The Key to Unlocking Sustainable Weight Loss With Fasting!⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Resources and Downloads: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠SIGN UP FOR THE DROP OF THE ULTIMATE GUIDE TO BLOOD SUGAR CONTROL⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠GRAB THE OPTIMAL RANGES FOR LAB WORK HERE! - NEW RESOURCE! ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠FREE RESOURCE - DOWNLOAD THE NEW BLUEPRINT TO FASTING FOR FAT LOSS!⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠SLEEP GUIDE DIRECT DOWNLOAD⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠DOWNLOAD THE FASTING TRANSFORMATION JOURNAL HERE!⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Partner Links: Get your⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ FREE BOX OF LMNT⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ hydration support for the perfect electrolyte balance for your fasting lifestyle with your first purchase⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ here!⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Get ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠25% off a Keto-Mojo⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ blood glucose and ketone monitor (discount shown at checkout)! ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Click here!⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Our Community: Let's continue the conversation. Click the link below to JOIN the ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Fasting For Life Community⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠, a group of like-minded, new, and experienced fasters! The first two rules of fasting need not apply! If you enjoy the podcast, please tap the stars below and consider leaving a short review on Apple Podcasts/iTunes. It takes less than 60 seconds, and it helps bring you the best original content each week. We also enjoy reading them! Article Links: https://www.sciencedirect.com/science/article/abs/pii/S1053811915007259 https://www.nature.com/articles/s41598-025-97370-z

Most women have been told their cycle is something to manage, track for fertility, or push through. What almost no one is saying is that your cycle is a second biological clock running inside your body at all times. The circadian rhythm is roughly 24 hours and is governed by light. The infradian rhythm is roughly 28 days and is governed by the menstrual cycle. Men have one main rhythm. Women have two. This is not a flaw in our design. It is added intelligence. In this solo episode, Michelle walks you through what is actually happening underneath the surface of each phase. Your brain structure shifts across the cycle. Your immune system, metabolism, insulin sensitivity, microbiome, and nervous system are all moving with you. You will learn why the same stressor can feel completely different from one week to the next, why luteal phase cravings are real signals and not willpower failures, and how to begin matching your work, food, and rest to the phase you are actually in. Whether you are trying to conceive or simply want to stop fighting your own body, this episode offers a more accurate map of how you are designed to function.   Key Takeaways: Women have two main biological rhythms. The circadian rhythm is roughly 24 hours. The infradian rhythm is roughly 28 days and is governed by the menstrual cycle. Most lifestyle and research advice is built around the male 24-hour clock, which is part of why so many women feel exhausted. Your brain structure literally changes across the cycle. The hippocampus shifts in volume, connectivity between regions changes, and verbal fluency, spatial reasoning, and pain perception all move with the phases. Feeling like a different person at different times of the month is neurobiology, not emotional volatility. Your immune system is rhythmic. It is more active in the first half of the cycle and shifts after ovulation, when progesterone becomes mildly immunosuppressive to prepare the uterus for a possible embryo. This is why colds, autoimmune flares, and allergies can shift across the month. Basal metabolic rate rises slightly in the luteal phase, and insulin sensitivity changes. The same meal can land differently depending on where you are in your cycle. Luteal phase cravings are often a real signal of higher energy needs. The gut and vaginal microbiomes also shift cyclically with hormones. You are not a static system. Everything inside your body moves with you. Heart rate variability tends to be higher in the follicular phase and lower in the luteal phase. The same stressor can land very differently depending on when in the month it arrives. Your nervous system is operating from a different baseline. From a TCM perspective, the liver works harder in the luteal phase to prepare for menstruation, which can show up as more irritability, less energy, and stagnation when qi is not flowing freely. Working with the cycle is not just a fertility tool. It is a way of living that supports energy, focus, mood, and recovery across the entire month. Practical starting points: track more than your period (energy, sleep, mood, focus, hunger, stress response), match the work to the phase when possible, and eat in a way that responds to what your body is actually doing in each phase.   Host Bio: Michelle Oravitz, L.Ac., FABORM, is a board-certified fertility acupuncturist, Ayurvedic practitioner, and author of The Way of Fertility. She is the host of The Wholesome Fertility Podcast, where she explores the intersection of Traditional Chinese Medicine, modern fertility science, nervous system health, and the deeper, often overlooked terrain of mind-body fertility. Through her clinical practice and online programs, Michelle works with women trying to conceive and with practitioners who want to bring a more holistic, integrated approach into their work.   Research and Resources Cited: Brain structure and function changes across the menstrual cycle (hippocampal volume) Cyclical changes in hippocampal volume across the menstrual cycle Menstrual cycle effects on cognition: verbal fluency and spatial reasoning Pain perception and threat sensitivity across the menstrual cycle Progesterone and immune modulation in the luteal phase Basal metabolic rate variation across the menstrual cycle Insulin sensitivity and the menstrual cycle Gut microbiome variation across the menstrual cycle Vaginal microbiome shifts across the menstrual cycle Heart rate variability across the menstrual cycle Cortisol and HPA axis response across the menstrual cycle   Disclaimer: The information shared on this podcast is for educational and informational purposes only and is not intended as medical advice. Please consult with your healthcare provider before making any changes to your health or fertility care.  Ready to discover what your body needs most on your fertility journey? Take the personalized quiz inside The Wholesome Fertility Journey and get tailored resources to meet you exactly where you are: https://www.michelleoravitz.com/the-wholesome-fertility-journey For more about my work and offerings, visit: www.michelleoravitz.com Curious about ancient wisdom for fertility? Grab my book The Way of Fertility: https://www.michelleoravitz.com/thewayoffertility Join the Wholesome Fertility Facebook Group for free resources & community support: https://www.facebook.com/groups/2149554308396504/ Connect with me on social: Instagram: @thewholesomelotusfertility Facebook: The Wholesome Lotus

Cortisol gets blamed for everything right now: belly fat, poor sleep, stress, fatigue, hormone issues, and even people's workouts.But is cortisol really the villain, or has the internet turned a normal human hormone into another thing to fear?In this episode, Coach JK shares his perspective on the cortisol conversation in a way that is less panic-driven and more practical. He looks at what cortisol is, when it is actually useful, where the fear-mongering goes too far, and why a 30-second social media checklist should not be treated like a diagnosis.This episode is for anyone who has heard about “cortisol belly,” wondered if their workouts are stressing their body too much, or felt like every symptom online somehow gets turned into a hormone problem.Referenced in today's episode:⁠HMU Ep. 227: Let's talk about bloating and inflammation⁠-------Connect with JK:Instagram: ⁠@coachJKmcleod⁠Email: JK@jkmcleod.com

(00:00:00) 221: Itchy & Bitchy ClinicCrawl: Your Dog Brought a Killer Into Your House; Skipping Your Meds could Kill You (00:00:11) Welcome to the Itchy and Bitchy Podcast (00:00:42) Doc Itchy Medical Pets Supplements (00:01:34) Hypertension and Medication Compliance (00:03:52) The Importance of Taking Medications as Prescribed (00:07:40) Ticks and Tick Prevention (00:11:34) Closing Remarks and Call to Action Two Silent Threats: What's Hiding on Your Dog and in Your Medicine CabinetItchy & Bitchy is the podcast for anyone who has ever felt dismissed, misdiagnosed, or gaslit by a broken medical system.  From gut health and hormone health to autoimmune disease and chronic pain, we investigate what science actually says. We examine functional medicine, holistic health, and alternative medicine with the same skeptical If it's pseudoscience, we'll call it. If it's medical gaslighting, patient advocacy failure, or misdiagnosis we'll call that too. For chronic illness warriors, self-advocacy seekers, and wellness skeptics WE OFFER  No filters. No BS. Just the truth your doctor didn't have time to tell you. Become a supporter of this podcast: https://www.spreaker.com/podcast/itchy-bitchy-podcast--4303608/support.Itchy & Bitchy: Have you felt dismissed, misdiagnosed, or gaslit by a broken medical system.  From gut health, hormones, autoimmune disease, chronic pain, holistic health, and alternative medicine ... medical gaslighting, patient advocacy , or misdiagnosis we'll call that too.  For chronic illness warriors, self-advocacy seekers: WE OFFER  No BS 

For our very first guest on the The Live Like a Girl podcast, I sat down with the woman who taught generations of us how to take back our financial power: Suze Orman.Here's why I had to start here. I spend my life helping women with hormones, weight loss, menopause, and underneath almost all of it sits one thing – cortisol. And when you scratch beneath the “cortisol surface,” so often what you find is money stress. So I brought in the icon herself to talk about what's really keeping women sick and stuck, and what to do about it.We get into self-worth and net worth, why women hand over their financial power, the spender-to-saver shift, divorce and the sandwich generation, the truth about your home and your car, what AI is about to do to all of us, and the money moves that matter most in 2026. Suze also shares her origin story – from waitress to financial icon and I know it will light a fire in you.This one is a masterclass. So bring a notebook and get ready. If you're wanting the deeper dive on exactly how to invest now, we're giving you a special offer of Suze's Masterclass: suzeorman.com/drmindyFor more resources related to today's episode, visit the podcast episode page: https://www.drmindypelz.com/ep345/  More on Suze Orman:Website: suzeorman.comInstagram: @therealsuzeormanYouTube: @suzeormanFacebook: Suze OrmanLinkedIn: Suze OrmanConnect with Dr. Mindy:Join Reset AcademyWatch the episodes on YouTubeFollow Dr. Mindy on InstagramSubscribe to Dr. Mindy's newsletter for tools and research on fasting, hormones, and metabolic healthDisclaimer: This podcast is intended for educational and informational purposes only and is not a substitute for professional medical advice. Always consult a qualified healthcare professional before making changes to your diet, fasting routine, or lifestyle.

If you've been struggling with your weight for years—or even decades—I want you to hear this clearly: It's not about the food.And in this episode, let's discover how your nervous system is actually controlling your cravings, your habits… and your ability to release weight.The First Agreement I Make With ClientsWhen I begin working with someone, we start with one important agreement: No weighing yourself.I know this can feel uncomfortable, especially when your goal is weight release.But focusing on the scale keeps you stuck in symptoms instead of addressing the root cause.Instead, I guide my clients to focus on:Their patternsTheir behaviorsTheir relationship with foodBecause that's where real change happens.The Real Problem Isn't FoodMost people think their issue is food.It's not.Because if it wasn't food, it could be:AlcoholSmokingAny other coping mechanismThe real issue is: The behavior behind the food.And that's exactly what I focus on.Your Nervous System Is Driving EverythingI look at hormones—but through behavior, emotions, and nervous system regulation.Your autonomic nervous system controls:HungerFullnessCravingsEmotional responsesThere are two key states:Sympathetic (Fight / Flight / Freeze)When you're in this state:Cortisol is elevatedBlood sugar stays highInsulin increasesYour body gets the message to:Store fatEat moreThis is where emotional eating, binge eating, and cravings live.Parasympathetic (Rest & Digest)This is where your body feels safe.And I want you to remember this: Weight release happens in the parasympathetic state.When your body feels safe:Cravings decreaseHormones regulateYour body no longer feels the need to hold onWhy I Don't Focus on Controlling FoodI don't teach people to control food.Because control always backfires.Instead, I focus on:Regulating the nervous systemReducing emotional triggersShifting behavioral patternsAnd when those behaviors fade… Weight release becomes a natural side effect.A Real Client StoryI recently worked with a client who went through a deeply emotional time—she lost her father very suddenly.During that time, our focus was not food.It was:Nervous system regulationEmotional supportProcessing traumaMonths later, she told me: She put on a pair of jeans she hadn't fit into in years… and they fit.We never focused on dieting.We focused on healing.The Root Cause of Emotional EatingSo many eating patterns are tied to:Past traumaStressAnxietyUnprocessed life eventsWhen we:Regulate the nervous systemProcess those experiencesCreate safety in the bodyThe urge to overeat… naturally dissolves.This work is about moving away from control… And stepping into awareness, safety, and real transformation. Because when your body feels safe… it no longer needs to hold on.Struggling with unwanted eating behavior? Download my free guide, Calm the Craving: 7 Steps to Break Emotional and Binge Eating, and finally end the cycle of out-of-control eating: www.sherryshaban.comWork With Sherry Shaban:Book your FREE 30-minute Food Freedom Call and start your journey to lasting change! www.sherryshabanfitness.com/clarityListen & SubscribeCatch more episodes at www.makepeacewithfood.com/podcast or subscribe on Spotify, Apple Podcasts, or YouTube so you never miss an episode!Connect & Go DeeperJoin our Facebook Community: www.myfoodfreedomlifestyle.comWork with Sherry: www.sherryshaban.com/transformExplore more resources: www.makepeacewithfood.comShare Your TakeawayTag us on Instagram (@makepeacewithfoodofficial), Facebook (@MakePeaceWithFoodOfficial), TikTok (@sherryshaban), or LinkedIn (sherryshaban) and share your biggest insight from this episode!

Larissa Schmidt ist Heilpraktikerin mit Schwerpunkt Kinderwunsch. Gemeinsam unterhalten wir uns darüber, wie man trotz Hormonstörungen wie PCOS (PMOS), Endometriose oder Östrogendominanz schwanger werden kann, wieso Toxine, Nährstoffe und Licht oft übersehen werden und welche Rolle Männer beim Kinderwunsch spielen. Und natürlich geht es auch um die riesen Themen: Stress und Cortisol als Kinderwunsch Killer.Außerdem stellen wir uns die Fragen: Wie kann man als Frau im Kapitalismus überhaupt seine Weiblichkeit leben und sprechen über die wichtigen Themen: Genährt Sein im Mama Alltag und Mamagesundheit. Wenn du mit Larissa zusammenarbeiten möchtest, dann kontaktiere sie hier: https://larissaschmidt.net/Und folge ihr gerne auf Instagram: @larissa.heilpraktikerin

The diet world just picked another champion. This time it's intermittent fasting. The case for it is real, and so is the 38% dropout rate. This episode looks at what the data shows about both approaches, what the neuroscience says about where sustainable fat loss lives, and what question every protocol conversation is actually trying to ask. In This Episode: 1. The debate is a setup. Comparing protocols means staying inside the diet industry's frame. The tool isn't the problem. The relationship underneath it is. 2. Intermittent fasting works for one reason: total calorie reduction. Clinical trials confirm real results and a 38% dropout rate, higher than participants who cut calories with no time-based structure at all.3. The body reads a fasting window as a starvation signal. Cortisol rises. Ghrelin surges. When the eating window opens on a system flooded with hunger chemistry, control doesn't just get harder. Biology takes over. The body is running exactly the software it was designed to run. 4. Years of restriction damage the one skill mindful eating depends on. Interoception: the ability to feel hunger and fullness accurately. Every rule followed in place of an internal signal trains us further from our own bodies. Mindful eating's job is to recalibrate the compass that dieting broke. 5. The neuroscience is direct. Mindful eating doesn't manage cravings from above. It changes the wiring below. Neuroimaging shows it physically quiets the brain's reward pathway and strengthens the circuits where deliberate choice lives. The food noise gets quieter because the brain has changed its response to the signal. 6. Every conversation about fat loss eventually arrives at the same question. Not which protocol to follow. Who do you want to be in relationship with food? The thermostat is always an identity question. Mindful eating works at that level. Everything else reaches around it. Ready to go deeper? If this one landed, the next step isn't another protocol. It's a different target entirely. Escape the Willpower Trap is where we do this work, changing the relationship with food, not the meal schedule. The quiet mind is waiting. The door is open: https://news.weightlossmindset.co/subscribe

(00:00:00) 218.2: Itchy & Bitchy ClinicCrawl: CPR and Cats Coughing up LungWorms (remix) (00:00:11) Welcome to The Itchy and Bitchy Podcast (00:04:55) The Importance of CPR Training (00:07:05) Closing Remarks and Next Episode (00:07:07) Doc Itchy Pet Supplements Your Cat Isn't Allergic — She Has WORMS in Her Lungs.Also, Do You Know CPR? Because You Might Need It After Reading This.Itchy & Bitchy is the podcast for anyone who has ever felt dismissed, misdiagnosed, or gaslit by a broken medical system.  From gut health and hormone health to autoimmune disease and chronic pain, we investigate what science actually says. We examine functional medicine, holistic health, and alternative medicine with the same skeptical If it's pseudoscience, we'll call it. If it's medical gaslighting, patient advocacy failure, or misdiagnosis we'll call that too. For chronic illness warriors, self-advocacy seekers, and wellness skeptics WE OFFER  No filters. No BS. Just the truth your doctor didn't have time to tell you. Become a supporter of this podcast: https://www.spreaker.com/podcast/itchy-bitchy-podcast--4303608/support.Itchy & Bitchy: Have you felt dismissed, misdiagnosed, or gaslit by a broken medical system.  From gut health, hormones, autoimmune disease, chronic pain, holistic health, and alternative medicine ... medical gaslighting, patient advocacy , or misdiagnosis we'll call that too.  For chronic illness warriors, self-advocacy seekers: WE OFFER  No BS 

What if one of the most important health crises affecting men today wasn't being caused by aging, but by the environment we live in? In this eye-opening solo episode, Darin Olien investigates the alarming decline in testosterone levels, fertility, and reproductive health among men worldwide. Drawing on decades of research, epidemiological studies, environmental science, endocrinology, and public health data, Darin examines the growing evidence connecting endocrine-disrupting chemicals, microplastics, sleep deprivation, chronic stress, poor lifestyle habits, and environmental toxins to declining testosterone levels across generations. From BPA, phthalates, atrazine, PFAS, and microplastics to sleep quality, circadian rhythms, cholesterol metabolism, cortisol regulation, and natural testosterone-supporting strategies, this episode explores what may be one of the most underreported public health issues of our time—and what men can do to take control of their health today.     What You'll Learn Why testosterone levels have been declining for decades The startling research on global sperm count decline How endocrine-disrupting chemicals interfere with hormone production Why BPA and phthalates may disrupt testosterone synthesis The role of atrazine, PFAS, and environmental toxins How chronic stress diverts resources away from testosterone production Why sleep may be the most important testosterone intervention The connection between cholesterol and hormone production How microplastics are being found throughout the human body The surprising relationship between statins and testosterone levels Natural lifestyle strategies that support healthy hormone production Practical steps to reduce environmental exposure and improve health     Chapters 00:00:00 – Welcome to SuperLife 00:00:33 – Sponsor: Fatty15 and cellular health 00:04:17 – The testosterone collapse explained 00:04:51 – Testosterone levels have been declining for decades 00:06:03 – Global sperm count decline and accelerating trends 00:07:02 – Why treating symptoms misses the root cause 00:07:27 – The hidden public health crisis 00:08:03 – Why low testosterone isn't just about aging 00:09:12 – Why hormone health affects longevity 00:09:53 – Low testosterone and increased mortality risk 00:10:35 – Testosterone's role in metabolism and cardiovascular health 00:11:27 – Endocrine-disrupting chemicals and hormone disruption 00:12:44 – BPA and its effects on testosterone production 00:13:59 – Phthalates and their impact on hormone pathways 00:16:00 – Glyphosate, atrazine, and pesticide exposure 00:17:07 – PFAS and reproductive health concerns 00:17:55 – Environmental toxins and population-wide effects 00:18:11 – Sponsor: Shakeology 00:20:02 – Cholesterol and hormone production 00:20:53 – Chronic stress and cortisol dominance 00:21:45 – Actionable solutions begin 00:21:56 – Why sleep is essential for testosterone production 00:23:07 – How sleep deprivation rapidly lowers testosterone 00:23:21 – Light pollution and circadian disruption 00:23:41 – Foods and nutrients needed for hormone health 00:24:23 – Microplastics and testicular tissue 00:24:53 – Statins and unintended hormonal consequences 00:25:39 – A practical testosterone sovereignty protocol 00:25:48 – Water filtration and reducing toxic exposure 00:26:13 – Eliminating plastics and fragrance chemicals 00:26:35 – Why organic food matters 00:26:45 – Sunlight and vitamin D 00:27:05 – Magnesium, omega-3s, and iodine 00:27:26 – Pine pollen and natural androgen support 00:28:01 – Tongkat Ali and ashwagandha 00:28:48 – Strength training and lifestyle interventions 00:29:10 – Habits that naturally support testosterone 00:29:27 – Darin's approach to healthy aging 00:29:37 – Plants, herbs, and common sense 00:29:51 – Reclaiming your health and sovereignty 00:30:00 – Final thoughts and closing message     Thank You to Our Sponsors Fatty15: Get an additional 15% off their 90-day subscription Starter Kit by going to fatty15.com/DARIN and using code DARIN at checkout. Shakeology: Get 15% off with code DARINO1BODI at Shakeology.com.     Join the SuperLife Patreon: This is where Darin now shares the deeper work: - weekly voice notes - ingredient trackers - wellness challenges - extended conversations - community accountability - sovereignty practices Join now for only $7.49/month at https://patreon.com/darinolien     Find More from Darin Olien: Website: darinolien.com Instagram: @darinolien Book: Fatal Conveniences Platform & Products: superlife.com New Show: Roadmap to Happiness     Key Takeaway "The testosterone crisis may be about far more than aging. It may be a reflection of the modern environment itself—one increasingly saturated with endocrine-disrupting chemicals, chronic stress, poor sleep, circadian disruption, and toxic exposures. While many of these forces feel outside our control, the encouraging reality is that many of the most powerful interventions remain accessible: improving sleep, reducing toxic load, eating whole foods, getting sunlight, managing stress, exercising regularly, and reclaiming responsibility for our health. The goal isn't fear. The goal is awareness—and action."     Bibliography/Sources: The Decline — Primary Research Levine, H., Jørgensen, N., Martino-Andrade, A., et al. (2022). Temporal trends in sperm count: A systematic review and meta-regression analysis of samples collected globally in the 20th and 21st centuries. Human Reproduction Update, 29(2), 157–176. https://doi.org/10.1093/humupd/dmac035 Lokeshwar, S. D., Patel, P., Fantus, R. J., et al. (2021). Decline in testosterone levels in men aged 15–40: Results from the National Health and Nutrition Examination Survey (NHANES), 1999–2016. World Journal of Urology, 39(2), 447–452. https://doi.org/10.1007/s00345-020-03227-1 Spital Clinic. (2026, March). Declining testosterone levels by generation. https://www.spitalclinic.com Travison, T. G., Araujo, A. B., O'Donnell, A. B., Kupelian, V., & McKinlay, J. B. (2007). A population-level decline in serum testosterone levels in American men. The Journal of Clinical Endocrinology & Metabolism, 92(1), 196–202. https://doi.org/10.1210/jc.2006-1375 Low Testosterone — Mortality & Disease Risk Muraleedharan, V., Marsh, H., Kapoor, D., Channer, K. S., & Jones, T. H. (2013). Testosterone deficiency is associated with increased risk of mortality and testosterone replacement improves survival in men with type 2 diabetes. European Journal of Endocrinology, 169(6), 725–733. https://doi.org/10.1530/EJE-13-0321 Shores, M. M., et al. (2006). Low testosterone associated with increased all-cause and cardiovascular mortality. Archives of Internal Medicine, 166(15), 1660–1665. https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/410754 Yeap, B. B., Marriott, R. J., Dwivedi, G., et al. (2024). Associations of testosterone and related hormones with all-cause and cardiovascular mortality and incident cardiovascular disease in men. Annals of Internal Medicine. https://doi.org/10.7326/M23-2781 Endocrine Disrupting Chemicals Associations between endocrine-disrupting chemical exposure and fertility outcomes: A decade of human epidemiological evidence. (2024). PubMed Central (PMC12299029). https://pmc.ncbi.nlm.nih.gov/articles/PMC12299029/ Hayes, T. B., Haston, K., Tsui, M., et al. (2002). Herbicides: Feminization of male frogs in the wild. Nature, 419, 895–896. https://doi.org/10.1038/419895a Mechanisms of testicular disruption from exposure to BPA and phthalates. (2020). Journal of Clinical Medicine, 9(2), 471. https://pmc.ncbi.nlm.nih.gov/articles/PMC7074154/ Meeker, J. D., Calafat, A. M., & Hauser, R. (2014). Urinary phthalate metabolites and their biotransformation products: Predictors and temporal variability among men and women. Journal of Exposure Science & Environmental Epidemiology. https://www.sciencedaily.com/releases/2014/08/140814124330.htm Zhao, Q., et al. (2023). Male reproductive toxicity of microplastics: Head and tail of the sperm. Science of the Total Environment, 872, 162181. https://doi.org/10.1016/j.scitotenv.2023.162181 Zhong, B., et al. (2024). Mixed EDC exposure associated with reductions in testosterone and free androgen index. Scientific Reports. https://doi.org/10.1038/s41598-024-76972-z Cortisol, Stress & the HPG Axis Bielohuby, M., et al. (2012). Swiss military cadets prolonged stress study. Psychoneuroendocrinology. Preprints.org. (2025). Sleep deprivation: A modifiable cause. https://doi.org/10.20944/preprints202505.0580.v1 SiPhox Health. (n.d.). Summary of Journal of Clinical Endocrinology & Metabolism data. https://www.siphoxhealth.com Viau, V. (2002). Functional cross-talk between the hypothalamic-pituitary-gonadal and -adrenal axes. Journal of Neuroendocrinology, 14(6), 506–513. https://doi.org/10.1046/j.1365-2826.2002.00798.x Sleep & Testosterone Leproult, R., & Van Cauter, E. (2011). Effect of 1 week of sleep restriction on testosterone levels in young healthy men. JAMA, 305(21), 2173–2174. https://jamanetwork.com/journals/jama/fullarticle/1029127 Reiter, R. J., et al. (2021). Melatonin and male reproductive health: Relationship to oxidative stress, mitochondrial function, and Leydig cell protection. Endocrine. Tan, D. X., Hardeland, R., Manchester, L. C., et al. (2023). Melatonin as a pleiotropic antioxidant hormone. Journal of Pineal Research. Nutrition — Zinc, Vitamin D, Cholesterol Corona, G., et al. (2010). Statin therapy and testosterone levels in men: A systematic review. The Journal of Sexual Medicine. Daniell, H. W. (2002). Hypogonadism in men consuming sustained-action oral opioids. The Journal of Pain, 3(5), 377–384. https://doi.org/10.1054/jpai.2002.126790 Pilz, S., Frisch, S., Koertke, H., et al. (2011). Effect of vitamin D supplementation on testosterone levels in men. Hormone and Metabolic Research, 43(3), 223–225. https://doi.org/10.1055/s-0030-1269854 Prasad, A. S., Mantzoros, C. S., Beck, F. W., Hess, J. W., & Brewer, G. J. (1996). Zinc status and serum testosterone levels of healthy adults. Nutrition, 12(5), 344–348. https://doi.org/10.1016/S0899-9007(96)80058-X Natural Testosterone Support — Botanical Evidence Pine pollen impacts testosterone-related symptoms in men. (2024). ACMCR Case Reports, 14(5), 1–9. Chinnappan, S. M., George, A., et al. (2021). Effect of Eurycoma longifolia standardised extract Physta on testosterone levels in ageing males: A randomised, double-blind, placebo-controlled multicentre study. Food & Nutrition Research, 65. https://doi.org/10.29219/fnr.v65.5647 Lazarev, A., & Bezuglov, E. (2021). Testosterone boosters intake in athletes: Current evidence and further directions. Endocrines, 2(2), 109–120. https://doi.org/10.3390/endocrines2020011 Leisegang, K., et al. (2022). Eurycoma longifolia (Tongkat Ali) improves serum total testosterone in men. Food & Nutrition Research. https://pubmed.ncbi.nlm.nih.gov/36013514/ Leitão, A. E., et al. (2021). 6-month double-blind RCT: Eurycoma longifolia 200mg + concurrent training. Maturitas. https://doi.org/10.1016/j.maturitas.2020.10.005 Lopresti, A. L., Smith, S. J., et al. (2019). An investigation into the stress-relieving and pharmacological actions of an ashwagandha extract. Medicine, 98(37), e17186. https://doi.org/10.1097/MD.0000000000017186 Pandit, S., Biswas, S., Jana, U., De, R. K., Mukhopadhyay, S. C., & Biswas, T. K. (2016). Clinical evaluation of purified shilajit on testosterone levels in healthy volunteers. Andrologia, 48(5), 570–575. https://doi.org/10.1111/and.12482 Saden-Krehula, M., Tajic, M., & Kolbah, D. (1971). Testosterone, epitestosterone and androstenedione in the pollen of Scotch pine Pinus sylvestris L. Experientia, 27(1), 108–109. https://doi.org/10.1007/BF02137731 Wankhede, S., Langade, D., Joshi, K., et al. (2015). Examining the effect of Withania somnifera supplementation on muscle strength and recovery: A randomized controlled trial. Journal of the International Society of Sports Nutrition, 12, 43. https://doi.org/10.1186/s12970-015-0104-9

If you're doing all the right things and still feel tired, wired at night, and stuck with weight that won't budge around your middle, this episode is for you.Most women think cortisol is just about stress. And friend, that is not the whole story. You can be managing your schedule, saying no when you need to, keeping your life under control, and your cortisol can still be running high all day long without you ever feeling stressed. I lived in that exact state for years and had no idea. I just thought the exhaustion, the belly weight, the brain fog, and the three a.m. wake-ups were my normal. They weren't. That was cortisol, and nobody warned me it was happening.In this episode, I'm walking you through what cortisol actually is, why it's not the villain it gets made out to be, and the five things that are really keeping it elevated. Most of them have nothing to do with feeling stressed. We'll talk about why chronic dieting quietly traps you in a loop that makes everything worse, what perimenopause does to your built-in calming hormone, and the real priority order for bringing your cortisol back down so your body can finally let go of what it's been holding onto.Whether you've been dieting for years, you're navigating perimenopause, or you're just tired of trying harder and getting nowhere, you deserve the whole picture. Your body is not broken. It's communicating.

In this episode, I'm getting into the thing that's quietly running your cortisol, tanking your hormones, and keeping your body in a permanent state of survival mode, and it's happening in your own home.Why codependency shows up in your body as stubborn fat, high insulin, and hormones that won't cooperate How the resentment you're carrying in your relationship is literally keeping your nervous system too dysregulated to lose weightThe difference between feeling safe at home and feeling safe in your body Why fixing your relationship patterns does more for your body than any protocol, plan, or hormone therapy aloneThis isn't relationship coaching. This is root cause. And this is the conversation nobody in the health and fitness space is having.Support the showHosted by Casey Shipp — 3000+ transformations, Self-Made Millionaire, High Priestess, Writer, Fitness Cover Model, and Founder of the Hotbody App.$30M client wins | $7.8M sold onlineRich isn't rare. Category of one is.

Listener Q+A.Chapters00:00 Personal Updates and Show Reflections07:02 Insights on Posing and Competition Dynamics08:48 Nutrition Adjustments and Lab Recommendations11:42 Understanding Photo Shoot Prep and Weight Gain14:45 CNS Priming and Athletic Training Insights17:45 Choosing Competition Suit Colors20:51 Net Carbs and Dietary Considerations23:57 Cortisol's Impact on Fat Loss27:01 Post-Workout Recovery Strategies29:45 Addressing Lagging Body Parts in Training32:43 Learning from Coaching Experiences35:49 Coaching Strategies for Weight Loss and Muscle GainLinksApply for Coaching: https://form.typeform.com/to/ubUfJiEu?utm_source=podcastLiving Lean Podcast: https://www.buzzsprout.com/712032Follow Jeremiah on Instagram: https://www.instagram.com/jeremiahbair/Follow Andrea on Instagram: https://www.instagram.com/andirogersfit/Follow Natalie on Instagram: https://www.instagram.com/natalieatswell/Keywordsbodybuilding, lab testing, training, physique, competition prep, nutrition, recovery, coachingTo Apply For Coaching With Our Team: CLICK HERE

Chronic stress doesn't feel like stress anymore — it feels like you. Here's what's actually happening in your body and the life changes that genuinely help. What You'll Learn in This Episode Why traits you've labeled "just how I am" — short fuse, bad sleep, wired-but-tired — may actually be chronic stress in disguise The difference between useful short-term stress and a nervous system that never returns to baseline What cortisol and adrenaline do when they stop being tools and become your permanent setting How chronic stress quietly degrades sleep, energy, mood, cravings, and your presence in relationships — often all at once Why so many people normalize survival mode, and the cultural story that makes exhaustion feel like a badge of honor The one habit Brett changed first that shifted his mood, energy, and anxiety without overhauling his entire life Why small, consistent signals to the nervous system outperform dramatic lifestyle overhauls every time Episode Timestamps [00:00] Introduction — the feeling of not being able to relax anymore [01:00] What chronic stress actually is — and why it starts to feel like your personality [03:00] Short-term stress vs. chronic stress: when the recovery stops happening [06:00] The biology: sympathetic vs. parasympathetic nervous system, cortisol, and the gas pedal that stays pressed [08:00] How chronic stress shows up in daily life: sleep, cravings, mood, decision fatigue, and relationships [12:00] Why people normalize survival mode — and the cultural story that keeps them there [16:00] Life changes that actually help — what works and what doesn't [20:00] Body vitality, the inner side of recovery, and reflection questions [21:30] A simple weekly practice to start sending your nervous system a different signal Episode Summary Most people carrying chronic stress have stopped recognizing it as stress. It's become the background hum of daily life — the reason you snap at someone you love over something small, the reason you're exhausted but can't wind down, the reason you reach for caffeine at 3 p.m. not because you want it but because your body is running on fumes and needs fast fuel. Brett's central argument in this episode is one worth sitting with: a lot of what people have accepted as "just who I am" is actually a nervous system that never got permission to come down from alert mode. The episode starts with a clear distinction that matters. Stress itself isn't the problem. Short-term stress — a deadline, a hard conversation, a demanding workout — is the system working exactly as designed. The body activates, responds, and then returns to baseline. That cycle, when it completes, is healthy. Chronic stress is what happens when the returning-to-baseline part stops happening. The threat passes, but the body keeps running the program. The alarm stays on long enough that you stop hearing it as an alarm. It just starts feeling like you. Biologically, this plays out through the sympathetic nervous system — the gas pedal — staying partially pressed all the time. Cortisol and adrenaline, hormones designed for temporary bursts, remain elevated far longer than they were built for. A body operating in that state starts making different decisions: about energy allocation, digestion, immune response, sleep architecture, and emotional regulation. This isn't abstract. Brett names the specific places it tends to land first: sleep that doesn't restore, cravings for sugar and caffeine to manage flagging energy, mood that has less buffer for frustration, decision fatigue that makes even simple choices feel like too much, and a kind of hollowed-out presence in relationships that people around you can feel even if no one says anything out loud. Brett shares his own experience of working sixteen-hour days while building his business — the point where snapping at family became his new normal, where he chalked up his irritability and absence to maybe just not being a good enough person. The reframe was significant: it wasn't a character problem. It was a pattern his nervous system had gotten stuck in, and when the pattern changed, so did he. The shift came not from a dramatic life overhaul but from committing to one thing: protecting seven hours of sleep, no matter how much was still on the list. Within days, mood improved. Anxiety dropped. Small frustrations started landing differently. That single-habit-first approach is at the heart of what this episode argues actually works. There's no supplement, no miracle routine, no overnight fix for a nervous system that's been in high alert for months or years. What works is smaller and more sustainable: repeated ordinary moments that signal to the body it's safe to stand down. Protecting sleep. Consistent movement that supports rather than depletes. Genuine stillness — five minutes with no phone, no multitasking, no optimizing. Time outdoors. Better nutrition that stabilizes energy instead of spiking and crashing it. Transitions between tasks and environments instead of going full speed until collapse. The episode closes with a reframe that sits at the core of the optYOUmize approach to building a physical foundation your body can actually recover in: recovery isn't a reward you earn after the to-do list is handled. That list will always keep filling. Recovery is part of how the system functions. A body and mind that get real rest make better decisions, have more patience, and have more capacity for the people and things that matter most. The goal isn't to eliminate stress. It's to stop designing a life where your body is constantly fighting your biology just to get through the day. Resources Mentioned Sleep research on chronic sleep deprivation — Brett references studies on sleep's long-term health impact as a turning point in changing his own habits High-quality protein for recovery — introduced through his son's hamstring injury; grilled fish and chicken as simple, practical staples Calming music, affirmations, and meditations — Brett's morning practice for setting tone and lowering baseline stress before the day begins Keep Exploring If this episode resonated, these are worth your time: Body & Vitality Pillar — The full framework for building a physical foundation that supports every other area of your life Enjoyed This Episode? The best way to support optYOUmize is to subscribe and leave a review — it takes about two minutes and makes a real difference in helping more people find the show. Apple Podcasts · Spotify · Amazon Music · YouTube Leave a Review →

Bauchfett in den Wechseljahren- Bauchfett verlieren ist der Wunsch von unfassbar vielen  Frauen ab ca. 40 Aber nichts scheint zu funktionieren.Chronisch erhöhtes Cortisol, sinkende Östrogenspiegel,  ein veränderter Stoffwechsel - unser Fett wird plötzlich  am Bauch gespeichert. All die Bauch-Challenges in den sozialen Medien machen es meist schlimmer- nicht selten sind Rückenschmerzen und ein verspannter Nacken die Folge, aber das Bauchfett- das bleibt. In dieser Episode erfährst du:✅ Warum zu wenig essen den Stoffwechsel bremst und Bauchfett festhält✅ Warum Bauchfett in den Wechseljahren nicht nur ein Kalorienproblem ist, sondern auch ein Hormonproblem  ✅ Warum Intervallfasten 16:8 ab 40 kontraproduktiv sein kann ✅ Warum mehr Cardio mehr Bauchfett bedeuten kann ✅ Was Alkohol wirklich mit deiner Fettverbrennung macht – nicht wegen der Kalorien, sondern wegen der Leber ✅ Warum Kreatin für Frauen ab 40 gerade so spannend ist ✅ Der Urlaubs-AHA: Das Gewicht nach dem Urlaub ist fast immer Wasser – kein echtes Fett ✅ Warum die Crash-Diät vor dem Urlaub das eigentliche Problem ist ✅ Was Sportanimation im Cluburlaub mit deinem Cortisol macht ✅ Nüchterninsulin – der Blutwert den fast kein Arzt misst und der alles erklären kann Du bekommst 8 Hacks, die auf jeden Fall funktionieren. Wenn du sie umsetzt

Sports medicine physician,endurance athlete and 1% Better Podcast host  - Dave Lipman - checks in for a wide-ranging conversation covering the realities of podcasting, the future of endurance technology, recovery methods, supplements, sleep tracking, heat adaptation, longevity trends, GLP-1s, peptides, and where the line should be drawn between performance enhancement and fair competition. Dave Lipman Links: Instagram: https://www.instagram.com/drdavidlipman/ 1% Better Podcast Instagram: https://www.instagram.com/onepercentbetterpod/| 1% Better Podcast on Spotify: https://open.spotify.com/show/4bG2U3dciEduX8c3PUtkrQ Matt Fox Links: Instagram: https://www.instagram.com/mattinglisfox/ Coaching: https://www.sweatelitecoaching.com/ Supporters Club: https://www.sweatelite.co/supporters YouTube: https://www.youtube.com/@SweatElite Matt welcomes Dave back to the podcast and the pair begin by discussing the realities of producing endurance content. They talk about the challenges of scheduling guests, dealing with cancellations and technical issues, recording in person versus remotely, and why some of the best conversations happen when the host and guest don't know each other particularly well beforehand. Dave also shares his podcast inspirations, what he currently listens to, and the endurance personalities he would most like to interview. The conversation then shifts toward the future of endurance performance technology. Dave discusses continuous lactate monitoring, multi-analyte sensors capable of tracking biomarkers such as glucose, ketones, cortisol, and hormones, as well as emerging ventilation and respiratory wearables. They explore whether future devices will be able to separate metabolic stress from mechanical and neuromuscular load, creating more useful insights than current metrics alone. Matt and Dave discuss the balance between useful data and over-analysis, touching on sleep tracking, orthosomnia, and how athletes can become overly reliant on wearable feedback. Dave explains why subjective feel still matters and why training should ultimately enhance enjoyment rather than create more stress. The discussion moves into supplements, with Dave outlining his practical framework for evaluating evidence and deciding what is worth using. They cover bicarbonate products such as Maurten Bicarb and Nomio, creatine, beta-alanine, beet nitrates, taurine, and the supplement trends currently gaining traction in endurance sport. Recovery strategies are another major focus. Dave reviews the evidence surrounding ice baths, sauna use, heat adaptation, active versus passive heat exposure, and how timing these interventions incorrectly may blunt training adaptations. They also discuss sweat rate adaptations, the interaction between heat and altitude training, and examples of accidental training breakthroughs that emerged from environmental stress. The final section of the conversation examines the rapidly growing longevity and biohacking space. Matt and Dave discuss Bryan Johnson, GLP-1 medications, peptides, anti-aging interventions, anti-doping gray areas, and whether amateur athletes should be held to different standards than professionals. The discussion expands into super shoes, emerging performance technologies, and how the sport may need to adapt as new forms of enhancement become increasingly accessible. Episode Chapters 00:00 Welcome Back Dave 01:01 Podcasting Struggles 02:59 Remote vs In Person 05:06 Editing Norwegian Method 06:56 Podcast Inspirations 07:58 What We Listen To 12:26 Dream Guests List 13:51 Better Interview Flow 16:43 Future Endurance Tech 19:53 Continuous Biomarkers 21:55 Mechanical Load Insights 27:06 Cortisol and Lactate Nuances 31:24 Lactate Compartments 32:56 Tech and Overthinking 36:06 Train for Enjoyment 36:44 Sleep Tracking Pitfalls 40:13 Supplements Framework 47:21 Creatine, Beta-Alanine, and Beets 53:44 Taurine and Trends 56:31 Ice Baths Net Effect 01:02:37 Sauna Heat Adaptation 01:05:52 Heat Training Benefits 01:06:28 Sweat Rate Tradeoffs 01:07:30 Active vs Passive Heat 01:08:38 Heat Plus Altitude Synergy 01:09:15 Accidental Breakthrough Block 01:12:05 Longevity and Bryan Johnson 01:13:15 Complex Systems and Lifestyle 01:17:28 GLP-1s and Doping Rules 01:22:39 Peptides Gray Market Risks 01:23:44 Amateur Standards and Fairness 01:26:28 Super Shoes and Gray Areas 01:33:22 Wrapping Up and Podcast Plug

(00:00:00) 221: From TikTok to Doctor's Office: The Truth About 'Cortisol Moon Face' (00:00:11) Welcome to the Itchy and Bitchy Podcast (00:00:42) Doc Itchy Medical Pets Supplements (00:01:05) Revisiting Cortisol Face Controversy (00:04:21) The Importance of Sleep in Young Adults (00:09:02) Melatonin's Benefits for Dogs and Humans (00:12:45) Brief Intermission (00:13:01) Hormones and Growth During Sleep (00:19:17) Second Intermission (00:19:45) Melatonin's Wide-Ranging Benefits (00:21:52) Melatonin Safety and Dosage Scroll through TikTok for five minutes and you'll find thousands of teenagers diagnosing themselves with "cortisol face"  puffy cheeks, a rounded jawline, swelling they swear is proof their stress hormones are out of control. It's everywhere. It's viral.And it's terrifying parents and confusing doctors in equal measure.We reveal what cortisol actually does to a teenager's face and body, how to tell a real hormone disorder from a viral delusion, and why dismissing every kid who brings this up to their doctor could be a dangerous mistake.Buckle up. This one's controversial.Become a supporter of this podcast: https://www.spreaker.com/podcast/itchy-and-bitchy-podcast--4303608/support.Itchy & Bitchy is back!  ... and the medical system is officially on notice.

Discover why hormones are off and what's really driving the imbalance. In this episode, we break down five root causes — from gut dysfunction and disrupted sleep to chronic stress, appetite dysregulation, and omega-3 deficiency — and walk through what you can actually do to fix it. FEATURED PRODUCT Berberine is a powerful botanical compound that acts as a natural GLP-1 supporter — the same metabolic pathway targeted by medications like Ozempic — helping regulate blood sugar, reduce insulin resistance, and restore appetite signaling from the gut. Since metabolic hormones like insulin and leptin are the first to derail your entire hormone cascade, Berberine directly addresses one of the deepest root causes discussed in this episode. It also supports gut microbiome diversity, making it a foundational tool for anyone working to reclaim hormonal balance naturally.

In addition to its role in the body's response to stress, cortisol is also important for metabolism and weight management, blood pressure levels, and immune function. And don't miss the following topics that Terry will also discuss on this show: Nutrient of the Day: Omega Fatty Acids, Slow Aging by Eating Right and Getting Decent Sleep, Increased Heart Disease Risk After Menopause.

SummaryIn this episode, Dr. Jen Belew shares her journey from traditional pharmacy to functional medicine, focusing on hormone health, stress management, and cardiovascular wellness for high-performing women. Discover practical insights on testing, hormone therapy, and lifestyle strategies to optimize health and prevent chronic disease.Chapters00:00 Introduction to Functional Medicine and Hormones02:34 Personal Journey into Functional Medicine05:24 Common Patterns in High-Performing Women07:08 Understanding Cortisol and Its Effects10:52 Testing for Cortisol Levels12:46 The Connection Between Stress and Cardiovascular Health18:16 Listening to Your Body's Signals26:46 The Importance of Comprehensive Health Assessments27:42 Unwinding the Past: Understanding Health Journeys30:00 The Importance of Sleep and Gut Health31:04 Hormones, Stress, and Brain Function38:12 Exploring Hormone Replacement Therapy46:08 Supplements: Tools for Wellness50:05 Fueling the Body: Nutrition and Self-CareResourcesBeyond the Dose - Dr. Jen Belew - https://www.beyondthedose.comFunctional Medicine Pharmacists Alliance - https://www.fmpa.orgDutch Testing for Cortisol - https://dutchtest.comRootCauseology - https://rootcauseology.com/

¿Sientes que tu cuerpo está inflamado, cansado, reteniendo grasa abdominal, perdiendo firmeza en la cara o funcionando cada vez más lento? Deja de resignarte pensando que es solamente el paso del tiempo o la edad. Tu organismo no está fallando; tienes un sistema nervioso atrapado en alerta constante y ejecutando un mecanismo de defensa.El cortisol fue diseñado biológicamente para ayudarte a sobrevivir momentos de peligro extremo. Sin embargo, cuando tu cuerpo vive demasiado tiempo en dinámicas de preocupación constante, tensión, miedo, sacrificio o hipervigilancia, esa inundación química se vuelve destructiva: termina degradando tus tejidos faciales, alterando tus hormonas y provocando una lentitud metabólica profunda en tu tiroides. Tu cuerpo está consumiendo toda su energía vital en defenderse de una guerra invisible.A través de esta sesión avanzada de reprogramación con el Método Yuen, entramos directamente a la consola de comandos de tu sistema operativo biológico para desactivar la alerta automática, liberar la tensión acumulada en las glándulas suprarrenales y devolverle la seguridad a tus células.⚙️ Lo que desconfiguramos y neutralizamos en este fortalecimiento técnico:• Apagado del Modo Supervivencia: Disminuimos el cortisol excesivo y sostenido, borrando la hipervigilancia acumulada y el almacenamiento de grasa por miedo.• Activación de Reparación Celular: Fortalecemos la función saludable de la tiroides, el intestino y el hígado para acelerar el metabolismo y eliminar la inflamación silenciosa.• Liberación de Tensión Estética: Borramos el endurecimiento facial por estrés y la tensión acumulada en el cuello y la mandíbula, devolviendo la elasticidad natural al rostro.Escucha este fortalecimiento las veces que sea necesario hasta que tu infraestructura física deje de vivir en guerra, recupere su estabilidad hormonal y comience a funcionar desde la calma y la expansión.⚠️ AVISO IMPORTANTE: El contenido de este video se presenta exclusivamente como un fortalecimiento energético y alternativa de regulación nerviosa bioeléctrica. No constituye, ni reemplaza bajo ninguna circunstancia, un diagnóstico, consulta o tratamiento médico, endocrino o profesional.Suscríbete al canal, activa las notificaciones y asume el mando biológico de tu sistema operativo.¿Lista para el cambio? Haz clic y comienza tu viaje hacia una vida sin límites.

Smoking! Its not just for your grandmother anymore! Wait... we're here to talk about anime? Well, we aren't getting paid by the tobacco industry so I guess we can just forget about it. How about some more takes on this anime season? We (the usual crew) check in on pint-sized witches, smokers, slimes, baseball, banashi, the works! Plus the usual news, recommendations, and usual shenanigans. 

In this episode Nancy McLean answers listener emails about geldings that chew lead ropes and reins, she explains how cortisol and the HPA axis relate to stress-driven behaviors, and describes how consistent training, handler calmness, routines, turnout, and nutrition can help horses down-regulate stress. The episode also summarizes research on cortisol sampling methods (plasma, saliva, hair) for short- and long-term stress assessment, and closes with a brief update on a new world screwworm outbreak, what has been done historically to eradicate it, and practical steps owners should take if they suspect infestation. Research: https://www.mdpi.com/2077-0472/13/12/2219 https://assets.cureus.com/uploads/review_article/pdf/413141/20251106-69309-xadaoe.pdf  

A 12-month clinical trial found that consistent aerobic exercise lowered long-term cortisol levels, showing your body can reduce chronic stress when you train it regularly About 150 minutes per week of moderate-to-vigorous movement was enough to create measurable changes, making stress reduction achievable with a realistic routine Cortisol is not just a stress hormone but a survival tool that stabilizes blood sugar, yet chronically high levels shift your body into a constant state of dysfunction Exercise improves your stress response even without weight loss, meaning your internal systems become more resilient before you see physical changes Combining steady exercise, enough carbohydrates, and proper recovery helps break the stress cycle at its root so your body stops reacting as if it's under constant threat

Perimenopause, Insulin Resistance, and Persistent Muscle & Joint Pain: A Functional Medicine Framework: Nutritionist Leyla Muedin discusses perimenopausal musculoskeletal symptoms—new or persistent joint pain, muscle aches, and tendon problems—and highlights a Clinician's Journal article by physical therapist Tara Moore proposing insulin resistance screening in perimenopausal musculoskeletal care. She explains that declining estradiol during the menopausal transition can worsen insulin signaling, increase visceral fat, and reduce insulin sensitivity, affecting skeletal muscle recovery and potentially contributing to tendinopathies and poor or short-lived responses to localized treatments like PT. The framework emphasizes assessing systemic metabolic contributors (e.g., sedentary behavior, high-carbohydrate nutrition patterns, PCOS, central weight gain, stress, sleep disruption) and addressing mediators such as inflammation and impaired glucose utilization. She suggests integrating metabolic risk assessment, sleep and stress strategies, resistance training, and interdisciplinary referrals, arguing that nutrition and supplementation—especially a low-carb approach—may improve recovery and pain outcomes.

Hey Diabuddy thank you for listening to show, send me some positive vibes with your favorite part of this episode.In this episode, Coach Ken sits down with Kelly Schmidt, diabetic dietitian and longtime Type 1 diabetes advocate, to have a deep conversation about one of the biggest topics in diabetes right now:With medications like Ozempic and other GLP-1-based therapies becoming more common, there are a lot of questions:1. Are these just weight-loss medications?2. Can people with Type 1 diabetes benefit from them?3. How do you use them safely?4. What happens with food, muscle, digestion, and long-term health?Kelly shares her personal experience using GLP-1 medications since 2017 and explains why these medications are about much more than weight loss. The conversation explores how GLP-1s impact appetite, digestion, hormones, inflammation, and blood sugar management.Ken and Kelly also discuss the difference between single agonists and dual agonists, why the “strongest” medication is not always the best medication, and why having conversations with your healthcare team is critical when deciding what works for your individual needs. The episode also dives into some of the biggest concerns people with Type 1 diabetes have:Can GLP-1 medications worsen gastroparesis?Do they cause bone loss?How do you protect muscle while using these medications?What role do protein and strength training play?Kelly shares practical guardrails around using these medications, including the importance of adequate nutrition, resistance training, and building systems that support your health—not just chasing a number on the scale.This episode is an honest conversation about a rapidly evolving area of diabetes care and how people with Type 1 diabetes can ask better questions, understand their options, and make informed decisions with their healthcare team.

Discover all of the podcasts in our network, search for specific episodes, get the Optimal Living Daily workbook, and learn more at: OLDPodcast.com. Episode 3427: Holly Jackson explores simple everyday activities that support emotional wellbeing, from gardening and walking in nature to meditation, mindfulness, cleaning, and hobbies. Along with practical suggestions, she highlights research showing how these activities can help regulate cortisol, boost mood-enhancing chemicals, reduce rumination, and encourage a calmer, more balanced state of mind. Read along with the original article(s) here: https://ellymcguinness.com/blog/exercise-as-stress-relief/ Quotes to ponder: "While washing the dishes, one should only be washing the dishes… The fact that I am standing here and washing is a wondrous reality." "Stress is one of those things which accumulates, so whenever you start to feel the tension build-up, take the time to do something you love, have a breather, and clear your mind." "Growing fresh, home-grown fruit and vegetables, and inhaling air while digging, can therefore be hugely beneficial to reducing stress levels." Episode references: Nature Experience Reduces Rumination and Subgenual Prefrontal Cortex Activation: https://www.pnas.org/doi/10.1073/pnas.1510459112 Thich Nhat Hanh — Mindfulness Practice: https://plumvillage.org/about/thich-nhat-hanh Effects of Nature Experience on Cortisol and Stress Response: https://www.frontiersin.org/articles/10.3389/fpsyg.2019.00722/full Learn more about your ad choices. Visit megaphone.fm/adchoices

Here's how the hardest reset on the planet actually works, and how to do it safely. Theo Lucier has spent over a decade studying dry fasting through his project Forgotten Health and his guided program Dry Fast with Friends. He breaks down why a true dry fast is different from a water fast, how the body burns fat for its own water, the endogenous stem cell release on day 5 and 7, and why the way you exit matters more than the fast itself. Meet our guest Theo Lucier is a natural health researcher and supplement formulator, founder of Forgotten Health, and co-creator of the Dry Fast with Friends community program with Sean McCormick. After overcoming severe chronic fatigue and 16 years of one-meal-a-day eating, he now focuses on dry fasting for stem cell release, cellular detox, and energy. Thank you to our partners Outliyr Biohacker's Peak Performance Shop: get exclusive discounts on cutting-edge health, wellness, & performance gear Ultimate Health Optimization Deals: a database of of all the current best biohacking deals on technology, supplements, systems and more Latest Summits, Conferences, Masterclasses, and Health Optimization Events: join me at the top events around the world FREE Outliyr Nootropics Mini-Course: gain mental clarity, energy, motivation, and focus Key takeaways A dry fast turns 100 grams of fat into 115 grams of metabolic water from within A water fast breaks down muscle and organ tissue; a dry fast spares lean mass A 5-day dry fast triggers one wave of stem cell release, a 7-day triggers two The Russian fat-loss method: a 24-hour dry fast plus a 6.2 mile walk, twice a week Day 3 is the hardest, when the body switches from glucose to ketone metabolism A soft dry fast with hydrogen peroxide baths supports detox better than a hard one Dry fasting is one of the few ways to quickly eject deuterium from the mitochondria Pre-tox for months first if you carry heavy toxic load How you refeed matters more than the fast: no sugar, sip water slowly to avoid edema Episode highlights 00:00 Important safety disclaimer 02:42 Introduction 04:21 What dry fasting is & what it feels like 06:06 Dry vs wet fasting (gluconeogenesis) 07:49 How 100g of fat becomes 115g of water 12:26 Endogenous stem cell release explained 16:48 The Russian "AK47" fat-loss method 22:44 Cortisol, stress & why day 3 is hardest 28:23 Changing your fat set point vs GLP-1s 40:02 How to pre-tox before a dry fast 47:19 Exiting safely: the most important part 58:32 Why dry fast "with friends" 1:02:16 Community results: mood, injuries, parasites 1:09:06 The program & how to join   Links Watch it on YouTube: https://youtu.be/69msEGyAXFQ Full episode show notes: https://outliyr.com/265  Connect with Nick on social media Instagram Twitter (X) YouTube LinkedIn Easy ways to support Subscribe Leave an Apple Podcast review Suggest a guest Do you have questions, thoughts, or feedback for us? Let me know in the show notes above and one of us will get back to you! Be an Outliyr, Nick

There's a concept you've probably heard before — set point.And in the world of dieting, it's often explained in one very limited way:“Your body prefers a certain weight.”But in this episode, I expand that idea into something far more honest… and far more empowering.Because your set point isn't just about your metabolism.1. Why Weight Always “Comes Back”You'll hear I intentionally use the term weight loss — and explain why that language matters.Because what we lose, we subconsciously try to regain.That's why:You can lose 20 pounds… and gain it backYou can try different diets… and end up in the same placeYou can feel like you're doing everything “right”… and still feel stuckIt's not a lack of discipline.It's that your body is returning to its current set point — the environment it recognizes as “normal.”2. Your Body Is a Reflection of Your Internal EnvironmentThis episode anchors into a powerful truth:Your physical body reflects your internal environment.That includes:Your weightYour aches and painsYour habits and self-sabotaging behaviorsThey're not random.They're signals.And instead of trying to control the body…I invites you to look at what's shaping it.3. The Biggest Lie About Set PointDiet culture teaches that your set point is determined by:MetabolismCaloriesExerciseMuscle massGeneticsAnd yes — those factors play a role.But they're not the full picture.Because if they were…changing your food alone would permanently change your weight.And for most people — it doesn't.4. Your Set Point Is Your Entire “Diet”And here's where everything shifts:Your diet is not just food.Your diet is:What you watchWhat you listen toWho you surround yourself withWhat you scroll throughWhat you tolerateWhat you repeatedly think and feelYour environment becomes your biology.5. Stress, Cortisol & Why You Feel StuckThis episode connects the dots between stress and weight in a deeper way.Because stress isn't just something you “feel.” It's something you consume.And it directly impacts your internal environment — which shapes your set point.So even if:You're eating “healthy.”You're exercising consistentlyIf your system is constantly in:pressurecomparisonanxietyurgencyYour body will adapt to that as your normal.6. The Invisible Influences You're OverlookingI call out something most people don't want to hear — but need to:Your set point is influenced by:Your friendsYour familyYour work environmentYour social mediaYour entertainment choicesIf your environment constantly triggers:comparisoninadequacypressure“not enough” energy…it reinforces a version of you that your body will reflect.7. Your Thoughts & Emotions Shape Your Set PointThis might be the most important piece:Your thoughts and emotions are part of your diet.If you consistently experience:anxietystressguiltshameoverwhelmThat becomes your internal baseline.And your body responds accordingly.Not because it's working against you —but because it's trying to stay consistent with what feels familiar.Struggling with emotional or binge eating? Download my free guide, Calm the Craving: 7 Steps to Break Emotional and Binge Eating and finally end the cycle of out-of-control eating: www.sherryshaban.comWork With Sherry Shaban:Book your FREE 30-minute Food Freedom Call and start your journey to lasting change! www.sherryshabanfitness.com/clarityListen & SubscribeCatch more episodes at www.makepeacewithfood.com/podcast or subscribe on Spotify, Apple Podcasts, or YouTube so you never miss an episode!Connect & Go DeeperJoin our Facebook Community: www.myfoodfreedomlifestyle.comWork with Sherry: www.sherryshaban.com/transformExplore more resources: www.makepeacewithfood.comShare Your TakeawayTag us on Instagram (@makepeacewithfoodofficial), Facebook (@MakePeaceWithFoodOfficial), TikTok (@sherryshaban), or LinkedIn (sherryshaban) and share your biggest insight from this episode!

Discover all of the podcasts in our network, search for specific episodes, get the Optimal Living Daily workbook, and learn more at: OLDPodcast.com. Episode 3427: Holly Jackson explores simple everyday activities that support emotional wellbeing, from gardening and walking in nature to meditation, mindfulness, cleaning, and hobbies. Along with practical suggestions, she highlights research showing how these activities can help regulate cortisol, boost mood-enhancing chemicals, reduce rumination, and encourage a calmer, more balanced state of mind. Read along with the original article(s) here: https://ellymcguinness.com/blog/exercise-as-stress-relief/ Quotes to ponder: "While washing the dishes, one should only be washing the dishes… The fact that I am standing here and washing is a wondrous reality." "Stress is one of those things which accumulates, so whenever you start to feel the tension build-up, take the time to do something you love, have a breather, and clear your mind." "Growing fresh, home-grown fruit and vegetables, and inhaling air while digging, can therefore be hugely beneficial to reducing stress levels." Episode references: Nature Experience Reduces Rumination and Subgenual Prefrontal Cortex Activation: https://www.pnas.org/doi/10.1073/pnas.1510459112 Thich Nhat Hanh — Mindfulness Practice: https://plumvillage.org/about/thich-nhat-hanh Effects of Nature Experience on Cortisol and Stress Response: https://www.frontiersin.org/articles/10.3389/fpsyg.2019.00722/full Learn more about your ad choices. Visit megaphone.fm/adchoices

Your body often tells the truth before your mind is ready to admit it. In this episode of Maximizing Hormones, Physique, and Running Through Perimenopause, Louise Valentine, a leading expert for perimenopausal active women and runners, shares a deeply personal look at what happens when major life stress collides with fitness, hormones, running, and midlife health. Through her own experience with devastating family news, interrupted sleep, inflammation, gut changes, low energy, and emotional overload, Louise explains why pushing harder is not always the answer, especially during perimenopause.Listeners will learn how to recognize when the body is reaching its stress tipping point, why exercise can become counterproductive when cortisol is already high, and how to adjust workouts, fueling, recovery, and lifestyle habits with more care. Louise also shares practical tools like eating more when sleep is disrupted, scaling back intensity, foam rolling with calming music, red light therapy, family connection, therapy, and brain spotting. This episode is a powerful reminder that resilience is not always about doing more. Sometimes, it starts with slowing down before your body forces you to.RESOURCES + LINKSLearn & level up with my free nutrition guide & award-winning 1:1 Badass Breakthrough Academy to thrive through perimenopause with less stress: https://www.breakingthroughwellness.com/ Learn & level up faster with a Breaking Through Wellness masterclass here, including my How to Support & Restore Your Gut Health Mini Course.Find a brain spotting therapist near you: https://brainspotting.com/directory/Explore client success stories & educational resources on my blog here.Read my best-selling book, The Art of Breaking Through, found on Amazon here.Explore Joovv Red Light Therapy devices here.Take advantage of our podcast listener discount & save 20% off Kion's science-backed clean products. Code "LOUISE" saves on all future orders: https://www.getkion.com/pages/maximizing Check out my FullScript here where you can see my curated favorite supplement picks, by topic, to address your concerns & save 25% off!  A small portion of EACH sale goes back to support BTW.  Thank you!Save $25 off Function Health comprehensive functional labs here. With every sale, $25 goes back to support BTW. Discount code is “LVALENTINE11” Thank you! Episode Highlights:(0:00) Intro(3:07) Adjusting fitness when life gets hard(7:52) Living openly through hard seasons(9:44) When training becomes stress control(15:00) Understanding the body's stress tipping point(17:09) Changing goals for health and longevity(25:27) How stress disrupts sleep and safety(27:17) Fueling more when the body needs support(30:15) Knowing when to stop pushing(31:42) Cortisol, gut health, and perimenopause(36:49) Choosing calm instead of more tasks(40:23) Family connection as recovery support(44:09) Brain spotting and therapy for stress patterns(49:24) Practical ways to adjust under high stress(52:38) Choosing presence, light movement, and support(54:05) OutroTune in weekly to "Maximizing Hormones, Physique, and Running Through Perimenopause" for our simple female-specific science-based revolution. Let's unlock our best with less stress!I'd love to connect!Email

After 30 years in health, Dr. Mindy is calling time on the rules.This solo episode is one of the most personal things she's shared on this podcast. It covers two big ideas: the science and story behind why she stopped fasting for most of the past year and the five health habits she's deliberately walking away from in 2026.First, flex fasting. When cortisol is high from grief, trauma, illness, perimenopause, or chronic stress rigidly pushing through long fasting windows doesn't support the body. It depletes it. Dr. Mindy shares what happened when she lost a close friend and found herself in an acute stress state, what the research says about prolonged fasting and the HPA axis, and how she developed a new approach she's calling flex fasting: a more intuitive, body-led way to use fasting as a tool without turning it into a rule.Then the five things she's giving up: counting (macros, biometrics, followers, all of it), the gym, other people's urgency, productivity over health, and information overconsumption. Each one is a direct response to what the wellness industry has quietly done to us — turned health into a full-time job with a performance review.RESOURCES MENTIONED:Fast Like a Girl: https://www.drmindypelz.com/booksAge Like a Girl: https://www.drmindypelz.com/booksSubstack Article "I Stopped Fasting for a Year": https://substack.com/@drmindypelz/Carb Manager App carbmanager.com, available on iOS, Android, and webThe Movement Diet: Redefining Fitness at Every Age with Katy BowmanStudy: Prolonged Fasting, HPA Axis & Cortisol - https://pmc.ncbi.nlm.nih.gov/articles/PMC12736288/Study: Estrogen & Cortisol Regulation - https://academic.oup.com/jcem/article/102/12/4457/4587523Midlife Women Fasting Trial - https://www.nature.com/articles/s41467-025-65678-zStudy: Self-Selected Fasting Windows - https://www.nature.com/articles/s41591-024-03375-yBEAM Minerals, use code MINDY for 20% off: https://www.beamminerals.com/?oid=4&affid=648LMNT, get a free sample pack with your order: https://bit.ly/drinklmntpelzTo view full show notes, resources mentioned, transcripts, and more, visit

Do you feel exhausted but can't seem to wind down? That wired-but-tired feeling so many women experience in midlife has a name, and a cause most doctors never address. In this episode of The Art of Living Well Podcast®, Marnie and Stephanie are joined by Dr. Scott Sherr, a board-certified internal medicine physician and expert in health optimization, to explore the connection between chronic stress, hormone changes, and mitochondrial dysfunction. Dr. Scott introduces the concept of the "sympathetic spiral of doom" — the cycle of stress, poor sleep, and cellular energy breakdown that keeps so many women stuck, and shares practical, science-backed ways to break it. The conversation covers methylene blue (what it is, how it works, and who should use it), GABA and nervous system support, and hyperbaric oxygen therapy. Dr. Scott also explains why only 6% of US adults have optimally functioning mitochondria, and what the other 94% can do about it. Key Takeaways: Chronic stress and hormone fluctuations directly impair mitochondrial function Estrogen is a critical mitochondrial optimizer, losing it in perimenopause has real cellular consequences Only 6% of US adults are metabolically healthy; symptoms of the rest range from brain fog to poor sleep to slow recovery Methylene blue supports mitochondrial energy production and works as a bridge while you optimize your health more broadly If a GABA supplement works for you, that's a warning sign worth paying attention to Down-regulating the nervous system too fast, without mitochondrial support, can cause a crash Hyperbaric oxygen therapy is most effective once you have a foundational health plan in place Sleep is one of the most powerful levers for mitochondrial health 00:00 – Introduction and Dr. Scott's background 04:13 – Why midlife women's bodies stop responding the way they used to 07:32 – Progesterone, GABA, and sleep disruption 09:04 – What mitochondria actually do and why they matter 13:16 – The 6% metabolic health statistic 17:00 – The sympathetic spiral of doom, explained 21:01 – Cortisol: misunderstood and mismanaged 29:32 – What methylene blue is and how to use it 33:55 – Who should not take methylene blue 38:33 – Performance, travel, and targeted use 47:17 – GABA support and down-regulating the nervous system 55:18 – Hyperbaric oxygen therapy: benefits, timing, and protocols 01:00:52 – One action to take today 01:03:09 – Where to find Dr. Scott and his products Guest Links: Dr. Scott Sherr: drscottsherr.com Troscriptions: troscriptions.com Use code LIVINGWELL for 10% off Products mentioned: Just Blue, Blue Cannatine, Tro Calm, Tro Zzz This episode is brought to you by Good Health Saunas. Visit goodhealthsaunas.com and mention The Art of Living Well Podcast® for exclusive pricing. Ready for a Reset, On Your Own Time? If you've been feeling sluggish, bloated, inflamed, foggy, or just not like yourself, our Vitality Reboot Anytime is a simple way to give your body the reset it's been craving. This is our do-it-yourself version of The Art of Living Well Podcast® community detox, designed so you can move through the program whenever it works best for you. You'll receive everything you need to support your body with nourishing foods, targeted detox support, and simple daily practices that help you feel lighter, clearer, and more energized. Subscribe to our Substack for wellness tips, episode updates, and your free Midlife Travel Resilience Checklist: theartoflivingwell.substack.com Follow us: Instagram: @theartofliving_well YouTube: @theartoflivingwellpodcast LinkedIn: The Art of Living Well Podcast TikTok: @theartoflivingwel Spotify and Apple Podcasts Connect with your hosts: theartoflivingwell.us/about-us

Acne is often treated like a surface problem, but what if your skin is actually signaling deeper imbalances inside the body? On this episode of Vitality Radio, Jared breaks down acne from a functional medicine perspective, exploring how hormones, liver function, gut health, stress, blood sugar, and the microbiome may all play a role in breakouts at every age. He discusses the connection between insulin, androgen balance, endocrine-disrupting chemicals, and inflammation, while also diving into the gut-skin axis and the importance of liver detoxification pathways. Jared also shares natural strategies he has used successfully for years, including targeted nutrition, probiotic support, endocrine detoxification support, and topical approaches that work with the skin rather than against it. Plus, he offers an honest discussion about Accutane, antibiotics, and why addressing root causes matters for long-term skin health.Products:LiverVitalityEndoCleanseBack On TractPrecision Probiotic Vital SporesTriple Action Nano-Silver Skin GelVisit the podcast website here: VitalityRadio.comYou can follow @vitalitynutritionbountiful and @vitalityradio on Instagram, or Vitality Radio and Vitality Nutrition on Facebook. Join us also in the Vitality Radio Podcast Listener Community on Facebook. Shop the products that Jared mentions at vitalitynutrition.com. Let us know your thoughts about this episode using the hashtag #vitalityradio and please rate and review us on Apple Podcasts. Thank you!Just a reminder that this podcast is for educational purposes only. The FDA has not evaluated the podcast. The information is not intended to diagnose, treat, cure, or prevent any disease. The advice given is not intended to replace the advice of your medical professional.

You've been told to get eight hours of sleep your whole life. Dr. Michael Breus — The Sleep Doctor — says that's not only wrong, it may be making things worse. In this conversation with Dwayne Kerrigan, one of the world's foremost sleep specialists breaks down the science of when to sleep, when to drink caffeine, when to workout, and why most people's sleep problems aren't about how much they sleep — they're about when. In this episode: The four chronotypes — Lion, Bear, Wolf, and Dolphin — and why knowing yours could reduce your total sleep while dramatically improving quality; plus why 55% of the population are Bears, and what that means for your nine-to-five schedule The 90-minute caffeine rule: how adrenaline and cortisol make caffeine useless for the first 90 minutes after waking, and when to stop caffeine entirely to protect your sleep The biology of the 1:00–3:00 AM wake-up: every human on Earth wakes up in this window due to a cortisol spike — and Dr. Breus's four-step protocol for getting back to sleep, including the four-seven-eight breathing technique developed by Dr. Andrew Weil for Navy snipers Why alcohol destroys Stage 3 and 4 deep sleep — the physical restoration stage where the brain's glymphatic system flushes beta amyloid and tau proteins linked to Alzheimer's disease — and the exact wine-with-dinner timing strategy that lets you drink without wrecking your sleep Sleep tracking devices: why none of them are accurate for measuring sleep stages, why rings outperform wristbands, why you should only review your tracker data once a week, and how to use trend analysis rather than nightly numbers Dr. Breus's personal disclosure: he has moderate obstructive sleep apnea and stops breathing 26 times an hour — and why he wants every listener to stop avoiding sleep testing out of fear Discover Your Chronotype - Take The Quiz: https://sleepdoctor.com/pages/dr-breus-podcast-dwayne-kerrigan Episode Highlights: 00:00 - Entrepreneurs Sleep Differently 00:33 - Welcome and Guest Introduction 01:06 - Tony Robbins Connection 03:17 - Meet Dr Michael Breus 05:05 - Middle of Night Awakenings 07:40 - Understanding Chronotypes 11:31 - The Lion Chronotype 12:47 - The Bear Chronotype 13:18 - The Wolf Chronotype 14:23 - The Dolphin Chronotype 18:07 - Bad Sleep Habits 20:39 - Morning Workouts and Cortisol 22:27 - Perfect Time for Sex 25:20 - Understanding Cortisol 26:37 - Why We Wake at 3AM 28:57 - Don't Go Pee 30:52 - Don't Look at the Clock 31:43 - Four Seven Eight Breathing 34:59 - Getting Out of Bed 36:28 - Stay Positive 38:06 - Breathing Technique Recap 38:51 - Breathing Techniques Really Work 42:50 - Alcohol and Sleep Quality 46:47 - Caffeine Timing Guidelines 49:49 - Cannabis and Sleep 51:39 - Understanding Sleep Stages 54:29 - Sleep Cycles Explained 56:11 - Sleep Tracking Devices 01:00:08 - Choosing the Right Tracker 01:04:18 - Heart Rate Variability 01:07:17 - Quality Over Quantity 01:08:46 - Sleep Apnea and Testing 01:12:12 - Finding Your Sleep Need 01:12:36 - Closing Thoughts and Stay Tuned for Part 2 Resources mentioned: Several of Dr. Michael Breus' books – The Power of When, Energize!, The Sleep Doctor's Diet Plan, Good Night, and Sleep, Drink, Breathe Four-seven-eight breathing technique — developed by Dr. Andrew Weil Muse headband — brainwave monitoring headband for sleep and meditation Oura Ring — sleep tracking ring Whoop Strap — activity and sleep tracker Apple Watch — sleep tracking The Happy Ring from Happy Sleep — FDA-approved ring for sleep studies Tony Robbins's book Unleash the Power Within Quotes: “Eight hours is a myth, man. So many people try to force themselves to get... The math doesn't even work. Like, the right number of cycles doesn't even end up at eight hours.” - Dr. Michael Breus “ I really, honestly, legitimately feel like I've dumbed myself down a little bit when it comes to, when it comes to my, like, abuse of sleep over the years.” - Dwayne Kerrigan “To be clear, dude, you are your best doctor. When you wake up in the morning, if you feel good, you feel good. Like, you slept well.” - Dr. Michael Breus “ The first liquid that crosses your lips every morning should not, I repeat, not be caffeinated.” - Dr. Michael Breus “ Stop thinking about hours. This is a quality game, not a quantity game. If you get six and a half hours of good quality sleep- As a sleep doctor, I am much more interested than if you get eight hours of crappy sleep.” - Dr. Michael Breus Dr. Michael Breus, Ph.D., is a double board-certified Clinical Psychologist and Clinical Sleep Specialist, and one of only 168 psychologists in the world to have passed the Sleep Medicine Boards without attending medical school. Known as The Sleep Doctor, he is the founder of sleepdoctor.com, was named the Top Sleep Specialist in California by Reader's Digest, and one of the 10 most influential people in sleep. He is the author of several books including The Power of When and Sleep, Drink, Breathe: Wellness is Too Complicated, and has appeared on Oprah, CNN, The Today Show, and The Dr. Oz Show more than 40 times, and lectures globally for organizations including YPO and Tony Robbins' Unleash the Power Within. Connect with Dr. Michael Breus: YouTube: Sleep Doctor Instagram: Sleep Doctor (@thesleepdoctor) Take the Original Chronotype Quiz | SleepDoctor.com Sleep Doctor At Home Sleep Test (SleepDoctor.com) The Sleep Doctor At-Home Sleep Test provides clinical-level sleep analysis from the comfort of your own bed. Using two simple sensors and a connected app, users receive personalized results reviewed by a licensed provider in under a week. Connect with Dwayne Kerrigan Facebook Instagram Linked In Website Disclaimer: The views, information, or opinions expressed by guests during The Dwayne Kerrigan Podcast are solely those of the individuals involved and do not necessarily represent those of Dwayne Kerrigan and his affiliates. Dwayne Kerrigan or The Dwayne Kerrigan Podcast is not responsible for and does not verify the accuracy of any of the information contained in the podcast series. The primary purpose of this podcast is to educate and inform. Listeners are advised to consult with a qualified professional or specialist before making any decisions based on the content of this podcast.

Are your hormones running your life, and not in a good way? If you are struggling with fatigue, mood swings, weight gain, or sleepless nights, this episode is the missing piece you have been looking for. Understanding hormone balance is not just about estrogen and progesterone. It starts much earlier in the hormonal chain, and getting to the root cause changes everything.In this episode of Salad with a Side of Fries, host Jenn Trepeck sits down with Dr. Andrea Colon, a naturopathic doctor and founder of Reclaim Integrative in Newport Beach, California, who specializes in women's hormone health and metabolic medicine. Together, they walk through the steps for lifestyle, nutrition, supplementation, and bioidentical hormone replacement therapy to restore balance, energy, and vitality. From understanding why cortisol imbalance is the upstream driver of so many symptoms women dismiss as inevitable aging, to exploring how to balance hormones naturally for women before ever adding HRT, this conversation is both practical and empowering.What You Will Learn in This Episode:✅ Why cortisol imbalance is the overlooked driver behind perimenopause symptoms, disrupted sleep, and stubborn menopause weight gain, and how chronic stress depletes your hormone production over time✅ How to use foundational nutrition strategies, including adequate protein intake, quality carbohydrates, and consistent meals, to begin restoring hormone balance before reaching for supplements or medications✅ Which key micronutrients, including vitamin D, iron, and B vitamins, are commonly depleted in women and how those deficiencies directly suppress healthy hormone function✅ How practitioners assess when lifestyle and herbs are enough versus when bioidentical hormone replacement therapy is the appropriate next step, including the role of pregnenolone, DHEA, and testosterone in womenThe Salad With a Side of Fries podcast, hosted by Jenn Trepeck, explores real-life wellness and weight-loss topics, debunking myths, misinformation, and flawed science surrounding nutrition and the food industry. Let's dive into wellness and weight loss for real life, including drinking, eating out, and skipping the grocery store.TIMESTAMPS: 00:00 Dr. Andrea Colon shares why restrictive diets backfire and how skipping meals worsens cortisol imbalance and hormone balance in women03:54 Dr. Colon shares her personal journey to naturopathic medicine after battling cystic acne 06:48 How stress and hormones connect and why women in their early 40s are entering perimenopause earlier due to cortisol09:16 Nutrition foundations for hormone balance, including protein, complex carbs, and avoiding coffee on an empty stomach 12:04 The truth about exercise and cortisol, why over-training causes menopause, weight gain and disrupts hormone function 14:39 Why sleep is the most underrated tool for hormone health and why catching up on sleep is a myth 18:53 Supplement strategies including vitamin D, iron, B vitamins, ashwagandha, and rhodiola for adrenal support 23:29 When to consider bioidentical hormone replacement therapy, including pellets, patches, creams, and pregnenolone29:05 Using a GLP-1 properly and when it is neededKEY TAKEAWAYS:

Dr. Liz Graves didn't set out to become a doctor. She discovered chiropractic as a patient, fell in love with its foundational philosophy that the body heals from the inside out, and built a career around that principle. Today, as the founder of Back 2 Real Food, she helps people restore their metabolic health through food, cyclic nutrition strategies, and targeted amino acid therapy — without relying on willpower, calorie restriction alone, or one-size-fits-all dieting.In this episode, Dr. Tara Perry sits down with Dr. Graves for a wide-ranging conversation on why so many people are doing "everything right" and still can't lose weight, what the modern food system is doing to our metabolism, and the counterintuitive strategies that actually work.Key Takeaways:The real reason diets stop working (00:07:00) — Every time you diet without recovery, your body adapts to living on less, slowing your metabolism over time. Dr. Graves explains her cyclic approach: a structured window of fat loss followed by a deliberate high-calorie phase that trains the body to metabolize more, not less.Seed oils are the #1 offender in your diet (00:16:44) — Vegetable, canola, sunflower, and safflower oils disrupt cell walls, cause inflammation at the cellular level, and impair mitochondrial function. Removing them is the first and fastest win Dr. Graves makes with every new client.Three foods worth adding right now (00:19:41) — Healthy natural fats (animal fats, olive oil, coconut oil), quality mineral-rich sea salt, and more whole foods without a label. Small additions that compound into meaningful change.Know your farmer (00:21:49) — Pesticide load, not the food itself, is driving the explosion in leaky gut, celiac, and autoimmune conditions. Dr. Graves recommends the Weston A. Price Foundation as a starting point for finding local farmers and co-ops, and makes the case that buying direct is often cheaper than buying organic at a grocery store.Targeted amino acid therapy changed everything (00:26:56) — Most people have never worked with a practitioner who assesses neurotransmitter imbalances and uses amino acids to correct them. Dr. Graves explains how depleted GABA, serotonin, and dopamine pathways fuel emotional eating, overwhelm, and burnout — and how replenishing them through targeted therapy gives people the neurological resilience to stay on course.Cortisol, stress, and weight retention (00:32:41) — Chronic low-grade stress (email, notifications, relentless demands) keeps the body in protective mode, holding weight and suppressing metabolic function. Dr. Graves connects the modern stress environment to the ancestral body we're still living in, and explains why supporting the brain matters as much as fixing the food.Body composition over the scale (00:58:06) — Dr. Graves uses body composition testing (muscle, fat, water, bone) rather than BMI or scale weight to track real progress. She shares the story of a five-foot-one woman with 105 pounds of muscle who technically "should" weigh 100 pounds — and why that framing is misleading and discouraging.What results actually look like (00:47:24) — On Dr. Graves' six-week protocol, most people lose about 10 pounds and drop one clothing size. On the nine-week plan, 15 to 30 pounds and two clothing sizes. She describes it as achieving six to nine months of focused progress in six to nine weeks — structured and demanding while you're in it, but consistently described as the easiest thing clients ever did when they look back.Ready to take your own next step?Visit calendly.com/consulttara/consult to book your free customized consultation with Dr. Tara Perry and get your GPS map — the coordinates for where you are now and where you want to go.

Dr. Deb Muth 00:00:09 Hi there, how are you? Bob Miller 00:00:10 Excellent! Pedaling as fast as humanly possible, but doing okay. Dr. Deb Muth 00:00:14 Good, good. Well, I’m looking forward to our conversation today. This should be amazing. Bob Miller 00:00:20 Yeah, it should be a lot of fun. Dr. Deb Muth 00:00:22 Yeah, anything that’s off-limits for you in, our conversation? Bob Miller 00:00:28 No. Dr. Deb Muth 00:00:29 Okay, anything you want me to make sure we cover for you? Bob Miller 00:00:33 Well, I mean, is it okay if we put a little plug-in for our software? Dr. Deb Muth 00:00:35 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:38 Hey, can we… can we do a screen share? Yes, we can. Yeah, because I want to show you some maps, and… Dr. Deb Muth 00:00:43 Okay. Things like that, yeah, so… Perfect. So just let me know when you want to do screen share. Bob Miller 00:00:48 Okay. Dr. Deb Muth 00:00:49 And yeah, feel free to plug your software wherever you want to. Bob Miller 00:00:53 Okay, well, good. Let me pull up a, a slide for that, and give me one second, I just want to shut the door to my office to get the noise down. Dr. Deb Muth 00:01:01 No worries. Bob Miller 00:01:16 And, how should I refer to you? Dr. Debb? Dr. Muth, what do you like? Dr. Deb Muth 00:01:18 Dr. Deb is great, or Deb, either way, I’m pretty informal, so… Bob Miller 00:01:22 Yeah, and… Bob is fine for me. Okay. Yeah. Yeah, there you go. Why people feel like they need this, son. Special name, it’s like, seriously. Dr. Deb Muth 00:01:33 Right? I agree. Bob Miller 00:01:35 When I work with my clients, it’s like, Dr. Millison, just, just bop, just, just bop. Dr. Deb Muth 00:01:41 Yep, that’s how I am, too. Just call me Deb, it’s good. Dr. Deb Muth 00:01:44 They feel a little awkward with that, you know? They’re not used to that, but… Bob Miller 00:01:48 Alright. And you’re a naturopath, medical doctor. Dr. Deb Muth 00:01:52 A nastropathic doctor and a nurse practitioner. Oh, nice. Yeah, so I got the best of both worlds, right? Bob Miller 00:01:58 Yeah, damn. Okay. Alright, so here we go… There we go. Alright, so I got that ready, and then I will do a, I will do a screen share. I think you’re gonna really, appreciate what we’ve come up with. We’ve come up with the concept of, Cellular CPR. Dr. Deb Muth 00:02:23 Oh, nice! Bob Miller 00:02:24 And that is, construct the cell membrane, Protect the cell membrane. And restore it if it’s damaged. Dr. Deb Muth 00:02:32 Love that. Bob Miller 00:02:34 I love that. Yeah, so that’s what we’re focusing on, and then how, You know, we want to get to the point that, you know, most people think of genetics, they think of, like, 23andMe or Ancestry. Dr. Deb Muth 00:02:44 Yeah. Bob Miller 00:02:45 And then you have the professional geneticists who are looking at, you know, odd things that could create a disease. We’re looking at functional genomics. Dr. Deb Muth 00:02:54 Which is so much better. Bob Miller 00:02:56 Yeah. Are you familiar with what we do here, or… Dr. Deb Muth 00:02:58 A little bit, a little bit. So, it’ll be new to me, too, so I’m excited. Bob Miller 00:03:03 And how much time do we have? Dr. Deb Muth 00:03:04 We have an hour, give or take a little bit on either side. Do you have a hard stop anywhere? Bob Miller 00:03:10 No, no, I put a, I moved my clients around, and I don’t have anybody till, 3.30, so we’re good. Okay. Dr. Deb Muth 00:03:16 Perfect. Alright. Bob Miller 00:03:18 It’s like we’re getting started early as well, so… Dr. Deb Muth 00:03:19 Yeah, we’re getting started a little bit early, so that’s good. Bob Miller 00:03:22 Yeah, I just got my office cleaned up, so… Dr. Deb Muth 00:03:23 Okay, good. All right, are you all set to get started? Bob Miller 00:03:28 I’m good to go, my friend. Dr. Deb Muth 00:03:29 I’m gonna just record a little intro and a little bit of a, hook for people, and then we’ll get started. I’ll ask you to kind of tell us a little bit about yourself, and then we’ll just take this conversation wherever it’s supposed to go. Bob Miller 00:03:39 Okay, you got it. Dr. Deb Muth 00:03:40 Alright, sounds good. So what if the reason you’re not healing isn’t your diet, your supplements, or your labs, but it’s actually your genes? Dr. Bob Miller is uncovering how genetic variants, when combined with modern toxins, explain why some of us stay sick no matter what we try. Today, we’re talking genetic pathways, detox blocks, and the new science every wellness warrior needs to know. Welcome back to Let’s Talk Wellness Now, the show where we uncover the root causes of chronic illness, exploring cutting-edge regenerative medicine, and empower you to heal from the inside out. I’m Dr. Deb, your medical detective, and today, our guest, Dr. Bob Miller, is a true pioneer in functional genomics. He’s a board-certified traditional naturopath and the founder of Neutrogenetic Research Institute. And he’s the leading groundbreaking research on how genetic variants influence chronic illness, inflammation, and detoxification. His work has been recognized on international stages, uncovering links between genetic expression and conditions like Lyme disease, mast cell activation, or MCAS, and mitochondrial dysfunction. I’m so excited to talk to Dr. Bob today. He is gonna reveal some things that even I don’t know about, so I’m excited to learn alongside of you guys. So… Dr. Bob, let’s get started. Tell us a little bit about yourself, and kind of how you got on this journey. Bob Miller 00:05:04 Well, that’s, that’s interesting. I was sort of like a mid-career coming to the natural health field, because in my early 30s, I found myself with a severe case of ulcerative colitis. Bob Miller 00:05:15 And I was in the hospital for 21 days. probably within hours of death, pleading to death. And they told me I’ve got one option, and that is cut out the colon and wear a bag. Didn’t sound like a lot of fun. Dr. Deb Muth 00:05:27 Not an option I would want. Bob Miller 00:05:29 So, you know, the medical folks wasn’t real happy with me, but I said, yeah, I’d like to explore some alternative things.Never thinking that I’d get into this field, and then I just, you know, worked with some herbalists and things that I found absolutely fascinating. So, that’s how I got into this around 30 years ago. And, haven’t looked back since, and just having a… having a blast as we now move into how our genetics impacts things. So, that’s what we’re gonna… that’s what we’re gonna talk about today. Dr. Deb Muth 00:05:58 I’m excited to talk about this genetic thing. When you started over 30 years ago, what kind of patience and problems first inspired you to dig deeper into that root cause healing and kind of get into the genetic piece of it? Bob Miller 00:06:10 Sure. Well, you know, as a… now, I’m in a part of the country called Lancaster County, Pennsylvania, where there’s a lot of Amish and Mennonite, and they gravitate towards these things.So, this is their first thing to do, and that doesn’t work, then they’ll go other routes. So, you know, back then, we just saw typical, you know, a little tired, constipation. You know, a little bit of fatigue, arthritis, those kind of things. But things have changed dramatically over the years, as people are now getting more chronically sick. You know, it’s worse than it’s ever been. And what we’re finding is the, the culprits Primarily is mold exposure and Lyme disease. When people get those two together, they’re just… it’s an inflammatory cascade that nobody can seem to unravel. So that’s where we spend a lot of our time. And we’re also spending a lot of time looking at mental health, like ADD, ADHD. And, we give… this year I’ll be speaking at three autism conferences. And we can dig into that a little bit as to why we think we’re seeing such a dramatic increase. And aside from autism, that used to be 1 out of 1,000, now it’s 1 out of 33, or 23. You know, we’re also seeing dramatic increases in ADD, ADHD. People are stressed out. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. Dr. Deb Muth 00:07:37 This should be a fun visit. We can cover lots of topics. I am so excited. So, you founded Nutri Genetic Research Institute in 2015. What did you hope to accomplish, and what kind of surprised you in your findings so far about that? Bob Miller 00:07:51 Well, you know, let’s back up at what, you know, genetics is used for. Everybody’s familiar with 23andMe and Ancestry that, you know, tells you where your ancestors came from. Then you have your professional geneticists. I mean, these are people with a degree in genetics. And they’ll look for, you know, very odd sort of things that are prone to relate to a disease. So there are disease-related genetics. Well, in functional, we don’t look at either of those. We look at For example, how you’re breaking down your fats and utilizing them. How you’re recycling your glutathione. How you might be handling your iron. And none of those are disease-causing on their own.And none of those are disease-causing on their own. But when they pile up on you, and then combine that with environmental factors, that’s when things start to go south on us. So, that’s what we’re doing, we’re looking at patterns. And our first foray into this was, we did studies on Lyme disease. And our first foray into this was, we did studies on Lyme disease. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. Others have a little more struggle, and then others are struggling terribly for years. So there’s an old adage of genetics loads the gun, environment pulls the trigger. Dr. Deb Muth 00:09:14 Yeah, that is so true, and I think when we’re talking about Lyme and mold and things like that, we forget sometimes that our genetics can predispose us to be more sensitive to those things, and if we have genetic pathways where we don’t clear things properly, it’s harder for us to get them out of the body. And then you add on that whole rain barrel effect that we’ve always used as a functional medicine term, right? If the barrel’s half full, you’re okay. If it’s full, and now it’s spilling over, it’s a bigger problem. Have you guys found, too, that some of these environmental things actually are changing the genetics of people, or how they’re processing their own genetics? Bob Miller 00:09:53 Well, let’s go back to, Genetics 101. But we’ll go back a little bit further. So, what an interesting mechanism, what a miracle the body is. Bob Miller 00:10:03 Fats, carbohydrates, proteins, drink water, breathe air, expose the sunlight, and somehow everything gets made. I mean, when you just step back and think about that, it’s like, It’s pretty darn amazing. Dr. Deb Muth 00:10:15 I always tell women, you know, the fact that we get pregnant and we have healthy pregnancies and births is a miracle, because if we had to try to control that, that wouldn’t work so well. Bob Miller 00:10:25 Right. Well, that’s another miracle. These microscopic sperm and egg, human being, 9 months later, it’s like. But even inside of us. We are making our hair, our skin, our nails, our blood vessels, our ATP, our energy, it’s all being created. Well, that gets created by enzymes. So, enzymes take one substance, combine it with something else, and make something new. Then another enzyme comes along and does the same thing. Your DNA is the instructions on how to make the enzymes. So, when we are conceived. If it’s a, if it’s a female, of course, it’s the XX, the two chromosomes. You know, we’ve… everybody’s seen those… the genetics that… Listed pair. So, if it’s a female, the father donated the X enzyme. And the mother has no choice but to give the eggs, so that’s female. If the father donates the Y, you have a male that’s in chromosome number 1. Then 2 through 23 is the rest of the instructions on how to make enzymes. So, what can happen? We can get what are called SNPs, single nucleotide polymorphisms. And SNPs just mean that the instructions to make the enzyme’s not quite as good. So, if one parent gives a SNP on the making of an enzyme, The enzyme’s fine. It works. But, general rule of thumb, It may only work at 70-80% of efficiency. Now, a good analogy is think of an 8-cylinder and a 6-cylinder car. If parents give you good information, that’s like having an 8-cylinder car. If one parent gives you that snip, it’s like having a 6-cylinder car. Now, is a 6-cylinder car a fine car? Sure. It’ll get you from point A to point B, but it’s just going to have the power of an 8-cylinder. Then if both parents give you a SNP on the same enzyme, it may be 30-40%, and that’s like having a 4-cylinder car. Sits in the driveway, looks the same, puts gas in it, everything. But if you’ve got a 4-cylinder car. Probably not a good idea to go cross-country pulling a trailer behind you up and down mountains. Dr. Deb Muth 00:12:29 This is true. Bob Miller 00:12:32 So… We can get an 8-cylinder, 6-cylinder, or 4-cylinder enzyme. Now, if it’s not under a lot of stress, if that 4-cylinder car is just taking you to the bank and the grocery store. It’s just as good as an 8-cylinder car. But if you gotta pull that trailer, and there’s a lot of stress on it, being mountains, it’s gonna struggle. Now, there’s one other little caveat to this, and that is some genetic mutations are gain-of-function. They actually work faster. Now, we have enzymes that do all kinds of things. We have enzymes that make and recycle our antioxidants, but we also have enzymes that make inflammation. No, that’s a good thing, because if we get a virus or bacteria, if you didn’t make inflammation to kill it, well, we’d all die of infection. So, you know, we tend to think of free radicals as bad, antioxidants as good. They both play an important role. But interestingly, some of the major enzymes that make inflammation, they can be overactive. They can be turbocharged. And when they’re stimulated by environmental toxins, they overreact. Bob Miller 00:13:40 And therein lies the problem. When they overreact, we have a problem. Bob Miller 00:13:46 So, if we have genes that overreact when stimulated. And then the enzymes that take care of inflammation are underactive. Then you’re gonna be more inflamed. You know, the majority of people that, you know, come for functional medicine Or naturopathic help, or… Inflammation that they can’t seem to get under control. Dr. Deb Muth 00:14:06 Right. Bob Miller 00:14:07 And we will be, you know, during this hour, we’re going to look at some of the pathways that make that happen. So, what we can do then, we can’t change our genetics. When you’re conceived, that’s the hand you’re dealt. When your life would be over, if someone would take some tissue and measure, it’d be exactly the same as conception. Does it change. Bob Miller 00:14:28 The enzyme’s ability to do its job may be compromised. Because remember I said there’s a, the enzyme takes a cofactor. So an enzyme takes substance A, cofactor, make substance B. Well, if that cofactor’s not there, the enzyme’s not going to work either. So, you could have an 8-cylinder car, and if there’s no gas in it, it’s not going anywhere. So… It’s the strength of the enzyme, it’s the cofactor to do the A to B conversion. And that’s what we’re going to get into. So, many people say, well, where did these SNPs come from? Nobody knows for sure. Sometimes they’re what’s just called de novo, when the sperm and egg go together, the instructions get mixed up a little bit. We do believe a lot of it came from a long time ago, when we were almost wiped out by sexually transmitted diseases. And those STDs were altering the genes when the conception, in other words, when the sperm went into the egg, the STDs were interfering. And causing the problem, so… I often joke, if you want to blame somebody. Blame your great-great-great-great-great-great-great-grandparents for, being a bit promiscuous, so… Dr. Deb Muth 00:15:31 Yeah, for being… having a little too much fun, right? Bob Miller 00:15:35 So, we don’t know for sure, but, you know, there are some that, But most of the SNPs that we get inherit from our parents. So, if you look at a child. And you look at the SNPs. 99.9% of the time, it came from one of the parents. Dr. Deb Muth 00:15:50 In identical twins, do they have the exact same identical makeup? Bob Miller 00:15:54 Yep, Dr. Deb Muth 00:15:56 But not in fraternal twins, correct? Bob Miller 00:15:59 No, no, those could be different, Jeff. Dr. Deb Muth 00:16:00 It could be different because they have different sacs, they’re not sharing that same genetic makeup. Bob Miller 00:16:04 Yeah, so keep in mind, both your mother and your father have, you know, the two And so you get one from one parent, one from another. Dr. Deb Muth 00:16:13 So… Bob Miller 00:16:14 Interesting situation. I had, 3, 3 boys. And, we were looking at an enzyme related to breaking down oxalates. Now, the mother and father each had one SNP, and that’s called heterozygous. Three boys, and they all come together, they’re Amish boys, they’re a lot of fun. And I looked at their genomes, and the one boy didn’t have any SNPs at all. And one had won. And the other one had two. Dr. Deb Muth 00:16:41 Interesting. Bob Miller 00:16:42 So, we don’t quite know how these things get handed off, but with the parents each having one, you could have a child with none, one, or two. So, the one, his ability to break down oxalates, which is fine. The other one was slightly impaired, and the other one was dramatically impaired. So, you can have 3 children, and it all depends what the parents have. Now, if a parent has a homozygous, or 2 copies. And the other parent has nothing. Every child will have one. Okay. If both parents are homozygous, that they both have two, Every child will have two. Dr. Deb Muth 00:17:19 too. Bob Miller 00:17:20 Yes, so that’s the way it works, but, you know, but it’s somewhat rare that both parents are homozygous on an enzyme, but it can happen. Dr. Deb Muth 00:17:27 Do we think that infections today, like Lyme disease or mold exposure, things like that, if the parent, the woman, primarily, I’m thinking, is pregnant, and she actively has these infections. Can those infections affect the genetics, kind of like a past sexual transmission did where we thought back in the day? Bob Miller 00:17:47 Yeah, I… I mean, I’m not that much of a geneticist to answer that for sure, but my thought would be no, that at conception, the pattern’s made. Dr. Deb Muth 00:17:55 Okay. And then that’s… that’s the hand you’re dealt. Bob Miller 00:17:58 Yeah. So, I tell people we have good news and bad news. The good news is we can compensate for the weakness. The bad news is we can compensate for the weakness. Dr. Deb Muth 00:18:09 That is so very true. Bob Miller 00:18:11 Yeah, we can’t, because I often get asked, so we’ll do some things now, and we’ll check my genes again, and they’ll be better. It’s like, nope. Dr. Deb Muth 00:18:18 Oh, – – Bob Miller 00:18:19 You gotta play the hands you’re dealt, so… Dr. Deb Muth 00:18:21 That’s right. Bob Miller 00:18:22 You can test your genetics… if you’re looking at the same enzyme, you can test it every year. It’s not gonna change. It’s like the blueprint. Dr. Deb Muth 00:18:30 It’s good and bad, right? It’s the one test you only have to do once in your lifetime. Bob Miller 00:18:34 No, unless, you know, like, our. Dr. Deb Muth 00:18:36 All the time. Bob Miller 00:18:37 Yeah, now our test looks at, called the Functional Genomic Analysis Test of your genomic Resource. We look at 220,000 steps. Dr. Deb Muth 00:18:46 Wow, that’s a lot. Bob Miller 00:18:47 That’s not all of them. Dr. Deb Muth 00:18:49 Right. Bob Miller 00:18:50 So, maybe in the next year, we’re gonna come out with our third version of the chip. And then, if someone wants to get those new things that weren’t on it, they’d have to repeat. But whatever we measured is gonna stay the same. Dr. Deb Muth 00:19:03 That’s a lot of SNPs to look at. Bob Miller 00:19:05 Keeps us busy. Dr. Deb Muth 00:19:06 But there’s still, but there’s still SNPs that we. Bob Miller 00:19:09 That we’d like to have that we don’t have, so… Bob Miller 00:19:11 We started out with version 1 on our genetic test, then we worked with version 2, and we’re already compiling a list of what version 3 would look like. So if somebody has our version 2, And we’re saying, you know what, it’d be nice if we could see these, well, then you’d repeat, but it won’t change what you already know, so… Dr. Deb Muth 00:19:29 Got it, got it. So, when you started out, and you started looking at the research of Lyme disease and chronic infections, which detox pathways are most important for people who struggle with those conditions? Bob Miller 00:19:43 Okay. You know what might make sense as we do a screen share, and I’ll actually show you the pathway. Does that make sense? Bob Miller 00:19:48 Alright, so… let’s see if I… let me just press the share… Dr. Deb Muth 00:19:52 Yep, you should just be able to press share. Bob Miller 00:19:54 And… number 2. Okay. Are we seeing the screen there? Bob Miller 00:20:01 Okay. Dr. Deb Muth 00:20:02 So, this is a map that we made. Bob Miller 00:20:05 And by the way, this is not… All-inclusive of all the things we look at, but we believe this is a core issue. So, where we’re going to start here, there’s something called the microglia. And the microglia are glial cells. They’re in the brain and the central nervous system. And they’re very interesting little creatures, because most of the time, and this is just a drawing of what they sort of look like. Most of the time, they’re in what’s called the M2 anti-inflammatory mood. What that means, these little guys pick up dirt, debris, Recycle them. Turns on an enzyme called interleukin-10 that’s anti-inflammatory. And just kind of does general housekeeping. And just kind of does general housekeeping. However, when a trigger comes along. However, when a trigger comes along. They… it’s the same glial cell, but it moves over to a very pro-inflammatory enzyme. A pro-inflammatory glial cell. And it triggers these 3 enzymes, Actually, these four. That are pro-inflammatory. Tumor necrosis vector alpha, Interleukin-6. NF Kappa B, Inos. Now, these create inflammation. So you might think, well, why is that good? Well, if you have some foreign invader, virus, bacteria coming in, parasite. If you didn’t have these guys coming to the rescue, you would just die of infection. So, these guys are your friend unless they’re your worst enemy. Because TNFA, and we’ll show you when we actually do a demo account, TNFA can be overactive. So, in other words, it over-responds. Interleukin-6 can be overactive. And if Kappa-B can be overactive. The INOS, and I’ll explain each of these as we go through a demo, can be overactive. Now, what that means is, you’re very good at killing virus and bacteria. But this is where autoimmune disease comes in, and just inflammatory conditions. Now, this is just speculation, but we think what happened is, as you know. Thousands of years ago, we didn’t have refrigeration, we didn’t have sewer, we didn’t have pure water, and we didn’t have antibiotics. So, if you made it to 40, you were an old-timer, because everybody was dying of infection. So, what we believe happened is, by what’s called natural selection, Having these overactive. A thousand years ago was to your advantage. Dr. Deb Muth 00:22:31 Hmm. Bob Miller 00:22:32 But now… We have pure water, we have refrigeration, we have sewers, we have antibiotics. But now we have environmental factors that are stimulating them. Now it’s to our disadvantage. And we’ll talk about that a little bit as it relates to the hemochromatosis genes and maybe the G6PD. Dr. Deb Muth 00:22:48 Yep. Bob Miller 00:22:49 Now, why are we becoming so inflamed? Let’s look at the triggers. Now, one of my, favorite expressions is. I was born all the way back in 1954. Dr. Deb Muth 00:23:01 And it was a different world back then. Bob Miller 00:23:05 These are some of the triggers. And we’ll get into these, but right now, high fructose corn syrup, And the high-fat diet. High fructose corn syrup only came about in 1968. So now we’re being exposed to high fructose corn syrup. Then… we didn’t have these, these viruses like COVID. Dr. Deb Muth 00:23:26 Yeah. Bob Miller 00:23:27 Now, there’s now pretty strong evidence that COVID Was actually, you know, made as a gain of function. It’s debated, and I’m not taking an opinion on it, but there’s some people who believe Lyme disease was also a part of experimentation. Dr. Deb Muth 00:23:40 Go. Bob Miller 00:23:41 Then we have molds, and it appears as though mold is getting stronger. you know, 20 years ago, when I was seeing folks, mold wasn’t on the radar. I would say 7 out of the 10 folks we speak to today have mold problems. Yeah, 20 years ago, we talked more about mold allergy being an issue versus mold toxicity being an issue. Right. So… I know some folks are, you know, speculating what’s happening, but one of the theories out there is that EMF is strengthening mold. I don’t know if you ever heard that theory, and I don’t… Dr. Deb Muth 00:24:13 I have. Bob Miller 00:24:14 I’m not claiming it’s true, but it’s an interesting theory. Then even, you know, your black mold from water-damaged buildings. Then our air pollution is getting worse. We’re getting more toxic metals. Dr. Deb Muth 00:24:26 You know, if we have a… Bob Miller 00:24:27 You know, we’re gonna look back someday and say, what were we thinking, smearing aluminum into our armpits? The, what were we doing putting mercury in our teeth? Then, you know, glyphosate. When I was a kid, there was no glyphosate. So, all of these herbicides and pesticides. Polychlorinated biphenols, And then EMF. So, we love our cell phones, you know, and I think unless you, or in the middle of the desert, or down in a cave, you’re being exposed to EMF somewhere. So, you know, we have our cell phones with us, we have, We have Wi-Fi, the towers are everywhere. And we don’t know long-term, but we may find that this can… this creates some inflammation. And I don’t know if you get any folks, but do you have any folks that have… are they EMF sensitive? Dr. Deb Muth 00:25:16 Oh yeah, we have a whole bunch of them. Bob Miller 00:25:18 Yeah, and then if you have any TBIs, So, plenty of things here. that will stimulate into the microglia, M1. Now, you could say, well. We’re all pretty much exposed to the same thing. Why do some people get hit harder than others? So here’s where we’re gonna start. There’s an enzyme called Nrf2 and RF2. And Nrf2 is the enzyme that senses when there’s inflammation. And turns on hundreds of anti-inflammatory enzymes. We’ll show when we do the demo, you can have genetic weakness on NERF2. And NERF2 inhibits and slows down microglia M1. supports M2. Now, if it’s not complicated enough, there’s an enzyme called KEEP1. And KEEP1 inhibits NRF2. And you can actually have gain of function on keep 1, that makes Keap 1 stronger. So… A lot of the people who land on my doorstep So… A lot of the people who land on my doorstep Both parents gave a mutation on KEEP1, making it overactive. Both parents gave a mutation on KEEP1, making it overactive. Dr. Deb Muth 00:26:31 Hmm. Dr. Deb Muth 00:26:31 Hmm. Bob Miller 00:26:32 Suppressing Nrf2, nerve 2 might be weak. So, nobody’s putting the brakes on, M1. And by the same token, Nerve 2 supports M2. Then there’s a process called mTOR and autophagy. mTOR stands for mammalian tard of rapamycin, the growth of new cells. And then autophagy, taking our dead cells and recycling them. We need a balance between the two of them. If we didn’t have mTOR, the sperm and the egg would never become the baby, the baby would never become the adult, we wouldn’t make new cells. But our cells are constantly, you know, the old cells dying off. Autophagy is where we take that debris from the cell and recycle it, just like a farmer Plows the crop under at the end of the year. The dead plant then becomes the fuel for the spring, your dead cell becomes the fuel for the spring, and that’s autophagy. So we’re gonna look back someday and say, what were we thinking? We give our animals growth hormones so they get fatter faster. Oh my. So, we consume those animals, and inventory runs faster. Now, for anybody who’s, You know, maybe above 40, 45 years old. Think back when you were 12, and what did girls look like? They were primarily flat-chested little girls. Now they look like 16-year-olds. Because environmentally, we’re jacking up mTOR. So, mTOR stimulates microglia M1, suppresses microglia M2. Probably 80% of the folks we visit with. This is the part of the problem. NRF2 is weak. mTOR is strong. Environmental factors come along. And this guy gets carried away. He doesn’t do that burst and move back. Stays here. We’re calling that How environmental factors create a locked-in, pro-inflammatory. and neurotoxic phenotype. In other words, once it starts, it just keeps… Feeding upon itself. Alright, so what happens now when microglia is overactive. it triggers these 3 enzymes, TNFA, N of kappa B, And interleukin-6. Each one of these can have genetics that make them run stronger. Then it stimulates an enzyme called NLRP3, Which makes what are called inflammasomes. Now, guess what inflammasomes can be? Your best friend or your worst enemy? Because they will, if you’ve got, again, a virus or bacteria, or possibly even some bad cells in the body. They will zap them. Well, that’s good. Unless it’s overactive. Unless it’s overactive. And then what it does, through interleukin-1 beta, makes excess glutamate. And then what it does, through interleukin-1 beta, makes excess glutamate. Anxiety, gut inflammation, OCD, ADD, autism. And, you know, glutamate, we’ll talk about that a little bit, but glutamate makes you intelligent, highly motivated go-getter. but can also be excitatory. And then, look what it does. Let’s see, do I have the drawing tool here? Yes, I do. Okay. So, it comes down through here, Makes the glutamate. Comes back up through here. through the ADORA 2A enzyme, Then we’ve got a feedback loop that feeds upon itself. Then, through interleukin-18, we make histamine. and mast cells. And then through histamine receptor site number 1, we come back and spin it. And now you’ve just got this spinning feedback loop. So, the glutamate will make you anxious, the histamine will give you allergies and make you anxious. And you’re allergic to everything, and you’re feeling horrible. Now, it doesn’t end there, Dr. Dad. It then goes on to make something called gast dermins that creates pyroptosis, where it actually starts punching a hole in the cell membrane. And you’re only going to be as healthy as your cells are. Just a little background. You know, we’re made up of trillions of cells, and each one of them has what’s called a lipid bilayer, made from lipids, which comes from fats. And you’re only going to be as healthy as those membranes are. So that’s why we coined an interesting phrase. Cellular CPR. Construct the cell. Protect the cell. And restore the cell membrane. And we believe that’s going to be revolutionary in the functional medicine world. So… It’s not hard to figure out that if you start punching holes in the cell membrane, that’s not a good thing, okay? Bob Miller 00:31:22 Now… There’s an interesting molecule called NAD. Thicotide adenoside dinucleotide. And anybody who’s in the, you know, listening to the health podcasts and things, they’re… They’re, they’re learning about NAD. And I’m going to show you a chart later, all the good things that NAD does, but For the most part, it helps what’s called sirtuins. And sirtuins are quite interesting. If anybody’s looking at longevity. The sirtuins is where they’re looking at.Because sirtuins turn on good things. Turn off bad things. And I’ll show some charts on that later. So for right here, this sirtuin uses NAD, to slow down NF-kappa-B. CERT 2 uses NAD to slow down an ORP3. So, if we’ve got genetic weakness on these, or we don’t have enough NAD, We don’t hold this pathway back. Make sense? Dr. Deb Muth 00:32:24 Yeah, makes perfect sense. Bob Miller 00:32:25 Now, I’ll show this a little bit later. So, people are like, oh, well, I’m gonna start taking some NAD. Dr. Deb Muth 00:32:31 Right. Bob Miller 00:32:32 And there’s functional doctors who give NAD intravenous. It was just this morning, I was talking to a woman who said, Oh my gosh. I went and got intravenous NAD, and it took me a month to recover from that. Dr. Deb Muth 00:32:45 Hmm. Bob Miller 00:32:46 what happens is, and I’ll show this in a little more detail, there’s an enzyme called CD38, that’s stimulated by NF-kappa-B. And it takes NAD, To make intracellular calcium. that stimulates NLRP3 and actually makes things worse. So, if we have this guy upregulated, and I’ll show a chart what does that. taking NAD will make you worse. Again, when I go into the software, I’ll show you that whole pathway, so… I would encourage people, you know, just don’t go out and start taking massive amounts of NAD, you know, stick your toe in the water, see how you do. Because everything you’ve heard about, how good it is, is true, unless this guy says, oh, thank you very much, let me make more inflammation. Now, this might be part of our innate immune system, that if we have some pathogen that’s gonna kill us. By golly, we want that to happen. But if this is happening by environmental factors, Then it’s detrimental. So the immune system that protected us a thousand years ago now might be turning on us because of the environmental factors that we showed earlier. All right. Then there’s an enzyme called PARP that’s NAD-dependent, and that actually repairs strain breaks in your DNA. Now, the next thing that happens… is there’s an enzyme called NADPH oxidase that gets stimulated. and something called INOS. Now, I’m sure most people know about nitric oxide. It’s a gas that dilates your blood vessels. That’s why sometimes they’ll even give people drugs, nitroglycerin, to boost their nitric oxide. That’s why people are doing beetroots and other things to boost their nitric oxide. But there’s an OS3 enzyme that makes the nitric oxide that’s good for blood flow. But there’s an INOS That makes nitric oxide to kill pathogens. probably might be the third or fourth time I’ve said this. That’s a good thing, unless it isn’t. So, if it’s killing some pathogen, great. It was just misfiring. it combines… With superoxide that’s made by this enzyme, and makes something called peroxynitrite, which is one nasty free radical that chews you up and spits you out. So, the NOx enzyme, NADPH oxidase, uses NADPH, To make this free radical called superoxide. If we have time, we’ll get into it. NADPH is what your body needs to recycle your antioxidants.So, I coined the phrase, the NADPH steel. Where the NOX enzyme takes this very important NADPH, And rather than being useful, makes superoxide. Now, again, is that fine if you’ve got some bacteria to kill? Of course. But if it’s just chronically running, it’s just making all this chronic inflammation. Then it makes something called hydrogen peroxide. And we need to clear hydrogen peroxide by 3 enzymes, catalase, thyroid reduction. And glutathione peroxidase. If we have genetic issues on here, or we don’t have the cofactors. There’s something called the Fenton reaction, discovered in 1895 by Dr. Fenton. Where hydrogen peroxide combines with iron to make what are called hydroxyl radicals. And guess what they do? They create lipid peroxides, That damages your cell membranes. Now, again, the body’s pretty darn amazing. We have glutathione, And here’s where your body’s taking glutathione and recycling it. But look who’s needed to recycle it. NADPH. So, if this guy up here is chewing it up, We don’t recycle our glutathione. And then an enzyme called glufon peroxidase 4, Takes this damaged lipid and repairs it. So, here we’ve got this protecting, we want to protect it by not having this happen. But then we also need this guy to do the restoration. So, there’s a lot that can go wrong in here, Dr. Deb. Dr. Deb Muth 00:37:07 There’s a lot that could go wrong. And I can imagine some of my listeners are thinking that lipid peroxidase, is that the same thing as what they’re thinking of when we talk about lipids and cholesterol? Is that the same process that’s happening there? Bob Miller 00:37:22 Well, no, no, the lipids can be used to make cholesterol, but here we’re talking about where they’re going to build the cell membrane. And they’re being… and they’re being, destroyed. If anybody would like to see a visual representation of this, just go on YouTube. And type in, ferrooptosis Animation. cool little video, it’s about 3 minutes long, and it shows the lipids coming over, being oxidized, and now GPX4 fixes them, so… YouTube, Pharaoptosis Animation, cute little video. It’s just that really… Shows vividly what we’re… what we’re talking about here. Now, this is… Dr. Deb Muth 00:37:59 And so this is very common, too. Like, a lot of people do hydrogen peroxide IVs. Dr. Deb Muth 00:38:04 And so, if somebody doesn’t know their genetics, they could have a problem with doing those, just like they could doing the NADHIVs, correct? Bob Miller 00:38:13 Sure, yeah, yeah, yeah. So, I’ve talked to so many, you know, of course, the hydrogen peroxide kills pathogens. I mean, that’s what it does. So… but I’ve spoken to so many people that said. I had one client that said they’ve never been the same after having one hydrogen peroxide infusion. Dr. Deb Muth 00:38:30 Interesting. Bob Miller 00:38:31 Yeah. So… it can be… I see why people use it, because it. Bob Miller 00:38:36 pathogens, But on the other hand. And now’s a good time to speak about… I don’t have it on here, but there’s a, there’s an enzyme called the HFE gene. And that is what causes you to absorb iron. And there’s mutations in it that cause something called hemochromatosis. Were you overabsorb iron? Now, true hemochromatosis is when both parents give you a mutation. But there’s now growing evidence even a heterozygous can cause a little bit more iron absorption, not to the human chromatosis point, but overabsorption. So, if you overabsorb iron, And you have too much hydrogen peroxide that’s not cleared, All kinds of inflammation. Now, what’s happened is sometimes this inflammation Will damage the red blood cells. And some well-meaning doctor says, oh, you need some iron. And they take iron and it makes it worse. So, can’t tell you how many people I’ve said, you’ve got the overabsorption of iron, and they say, well, that can’t be right, because I’m low in iron. Well, that could be because it’s being chewed up here. Dr. Deb Muth 00:39:40 Sure. GPX1 and TXN turn it into, to water. The, catalase turns it into water and oxygen. Dr. Deb Muth 00:39:58 Now, I see a lot of my clients who have mutations or SNPs on that GPX gene, on that glutathione gene. And they really struggle to clear a lot of their toxins. Bob Miller 00:40:12 Sure. Dr. Deb Muth 00:40:14 Yeah, absolutely. Well, GPX4. Bob Miller 00:40:18 is what, repairs, but you can see GPX1 Is what uses glutathione. To turn hydrogen peroxide. So, but it all depends upon having enough glutathione. Dr. Deb Muth 00:40:30 Yeah. Bob Miller 00:40:31 Well, guess who controls making a glutathione? Dr. Deb Muth 00:40:34 Nerf 2. Bob Miller 00:40:37 So, if you have a keep one weakness, or strength to two… I’m sorry, keep one is too strong. Nrf2 is too weak. You don’t make glutathione. So, when a lot of people do that, it’s like, well, I’m gonna take glutathione. Dr. Deb Muth 00:40:51 Right. Bob Miller 00:40:52 And some do great, and some do poorly. You know, because… and I’ll show this on one of the other charts. You can see here that the, The glutathione has to be recycled. And if we don’t recycle it, it actually turns into superoxide free radical. So… NADPH are the cofactors, For taking the oxidi… here’s oxidized glutathione, here’s reduced. So, this is a good glutathione. After it does its job, you can see it becomes oxidized.We need to recycle it. Well, if we have weakness on the enzyme that does that, or a weakness in Nrf2, or not enough NADPH. The oxidized glutathione never gets recycled. So, I’ve talked to a lot of people who said, oh, glutathione made me so sick, and say, well. Dr. Deb Muth 00:41:43 Yeah. Bob Miller 00:41:44 You need it, but you need to recycle it. Dr. Deb Muth 00:41:46 Can you speak for just a brief moment, too, about MTHFR? That is a very popular gene, it’s all over social media as the major gene, but can you speak to a little bit about that, and how that fits into this whole process of things? Because it is just such a small piece. Dr. Deb Muth 00:42:04 understanding genetics. Bob Miller 00:42:06 Yeah, to be honest, it drives me nuts. Dr. Deb Muth 00:42:08 Me too. Bob Miller 00:42:11 Alright, so… You know, there are people on social media I won’t say what I think, I’ll be kind. But… But the, And, you know, they might mean well. But they talk about, if you have MTHFR and COMT and PEMT, that’s… oh my goodness, that’s horrible, and we’ll fix that for you, and you’ll be fine. Bob Miller 00:42:36 it just irritates me to no end. And it really could get anybody who’s doing this legitimately in trouble. I mean, I’m afraid someday, you know, there might be some cracking down on this kind of nonsense. Now, to answer your question about MTHFR. Dr. Deb Muth 00:42:51 I mean, it really is, but I’ll tell you what, why don’t we hold that thought until I go to another map and I can actually… Okay. Bob Miller 00:42:56 But the real… the cliff notes is the MTHFR puts a methyl group on your folate, which is needed, but it has gotten way, way, way too much attention. And people learn they have MTHFR, and they start taking a multivitamin with methylfolate, then they take a B vitamin with methylfolate. Dr. Deb Muth 00:43:13 And they’re pushing it too hard. Bob Miller 00:43:15 Yeah. So I can’t tell you how many people I’ve helped by saying, stop it. Dr. Deb Muth 00:43:20 Yeah, take less of it. Bob Miller 00:43:21 Take less of it, yeah. So, yeah. Yeah, there’s a… If somebody, say, ranked the enzymes at their level of importance, MTHFR might be 40 or 50 on a scale of 100, you know. Keep one Nerf two. big deals. Dr. Deb Muth 00:43:40 deals. Bob Miller 00:43:41 NQO1 that I didn’t even talk about yet, NQO1, takes your, NA… your NAD goes into NADH, To make electrons for the electron transport chain. you need NQ01 to bring that back. If that’s not working, and I’ll show you on the NAD map how disastrous that can be. Now, the next piece is here, and I think You know, if you talk to any school teachers and say, if you’ve taught for more than 10 years, how are the kids today? Every one of them says, more ADD, ADHD, more autism. Just look at human beings, we’ve never been so agitated. You know, everybody, and it might be a social media thing, but people take a position on something, and if anybody doesn’t share that position, they view them as the enemy. Dr. Deb Muth 00:44:29 And it’s kind of scary what’s happening to us. Bob Miller 00:44:33 So, we can’t agree to disagree anymore. We see anybody who has a differing opinion as the enemy. And, you know, there was… there’s people that didn’t have Christmas dinners together, because they had political differences, like… Dr. Deb Muth 00:44:44 Excuse me. Bob Miller 00:44:45 can’t you put your political differences aside to have Christmas together, you know? Dr. Deb Muth 00:44:49 Right? Bob Miller 00:44:50 become that, you know, no matter what your position is, and I’m not saying anyone’s right or wrong, I’m just saying. You know, in the old days, they used to say that the Republicans and Democrats in Congress would argue policy and then go have dinner together. And now everybody’s all up in arms, angry. Dr. Deb Muth 00:45:05 Yeah. Bob Miller 00:45:06 So… There’s likely multiple reasons for that. But let me show you one of them. That, you know, to what degree this is… very important, we don’t know, but I think We’re beginning to believe this is very important. So, there’s something… there’s a neurotransmitter called GABA. And God buys the don’t worry, relax, be happy. Chill. Okay. Dr. Deb Muth 00:45:31 Nobody has enough of that anymore. Bob Miller 00:45:33 Well, yeah, you’ll be surprised what I’m gonna show you. So, let me see if I can find a, Let me see if I can find the right slide here. Let me look for it here. So, there’s something called a GABA receptor site. And here you can see… This is a neuron, and this is where you, The neuron normally is excitatory. However, there’s normally low chloride in the neuron. Dr. Deb Muth 00:46:09 Hmm. Bob Miller 00:46:10 So, GABA itself is neither relaxing. For excitatory, all GABA does, it opens up what’s called a chloride channel. And then chloride, which has a negative charge, will flow into the neuron. Follow me there? Dr. Deb Muth 00:46:26 Yep. Bob Miller 00:46:27 And as it does, it changes this from a positive charge to a negative charge, And it’s relaxing. and inhibitory. Dr. Deb Muth 00:46:34 Hmm. Bob Miller 00:46:36 Now, on the other hand, there’s enzymes called NKCC1, That will push chloride in. and KCC2 that will bring chlor… oops and bring chloride out. And then there’s a sodium channel. And, sodium has a positive charge. And glutamate will push that in. So, as long as this is happening. And GABA says, receptor sites, open, chloride goes in, Chill. However, If NKCC1 Pushes extra chloride in. KCC2 doesn’t pull it out. and GABA hits the receptor site, the GABA comes flowing out, Sodium comes in, And now it’s excitatory. So Gabba didn’t change. GABA just opened the receptor site, that’s all it does. Dr. Deb Muth 00:47:33 Yeah. Bob Miller 00:47:34 But it’s the chloride balance that’s going to determine whether this is relaxing or not. Now, these are the things that go along with when they lose that KCC2 or gain NKCC1. Pain and sensitivity, burning electrical, neuropathic pain. Normal touch hurts. Sound and light sensitivity. Tinnitus can flare. Headaches and migraines. Seizure tendency. Body jolts. Spasticity, cramps, stiffness, startle reflex. Trouble falling asleep, non-restorative sleep. Anxiety, stress, reactivity, that’s what we have now. Hyperarousal, panic-like surges, irritability, racing thoughts. Brain fog, slowed processing, working memory slip-ups. Mental fatigue. Episodes of racing hearts, sweaty palms, guts on edge. Those are all the things that happen when this GABA switch occurs. Now, here’s what happens, and this is what I’m going to be presenting at an autism conference. When you have a newborn, they need that NKCC dominant to develop. By early childhood, it should… or, sorry, early adulthood. we should move over to the KCC dominant, that’s the taking the chloride out. Nice-looking 25-year-old boys, functioning very well. However, when we get microglia M1 upregulated. Because of environmental toxins, processed foods, Tylenol, aluminum. they stay in NKCC1 dominant, and there’s ADD, ADHD, Autism, the whole spectrum. because… They’ve not moved over to the… They’ve not moved over to the KCC2. And again, this is caused by… Environmental factors. Stimulating the microglia. And then, interleukin-1, interleukin-18 weakens KCC2, interleukin-1 beta, Strengthens NKCC1. high chloride. We open up the chloride channel, In Rebell Excitatory. So, I think when, When the pediatricians get ahold of this, they’re going to be very excited to know that This could be why we’re seeing such a rise, and not just autism, but ADD, ADHD, anxiety, the whole shit mess. Dr. Deb Muth 00:49:58 thing. Bob Miller 00:49:59 Yeah, so… and you can see NF-kappa-B stimulates that. These stimulate it, and I think that’s why everyone’s getting so anxious. Now, there’s a little bit more to it, and we’ll get into this when we look at some of the maps, but… The, the glutamate, Which is excitatory. will stimulate the NMDA receptor, make more glutamate, And glutamate will inhibit KCC2. And then we also need an astrocyte To, take both ammonia And glutamate, and… Turn them back into glutamine. And I’m going to talk to you a little bit about arachidenic acid, and if we have too much arachidenic acid. or TNFA is upregulated, that doesn’t happen. Ammonia goes up, and there may be multiple reasons for this, but this is a reason why some of the autistic kids do flapping. Dr. Deb Muth 00:50:49 Hmm. Bob Miller 00:50:50 Because they’re not clearing their ammonia. And you can tell if somebody has high ammonia by… they get that old person smell, you know. Dr. Deb Muth 00:51:00 Yup. Bob Miller 00:51:01 your vehicle cycle’s not taking out the, the ammonia. Now, last pathway here. There’s growing interest in mast cell activation. So, back here, we talked about peroxynitride. And that will stimulate mast cells, and those are white blood cells that are your best friend, unless they’re your worst enemy. Then it’ll make histamine. And there’s enzymes called histidine decarboxylase that’ll make more. Dr. Deb Muth 00:51:28 I’m sure everybody’s heard of DAO, the enzyme that degrades histamine. Yep. Bob Miller 00:51:31 We can have genetic weakness, we don’t make that. There’s an enzyme called histamine and methyltransferase, That, That breaks down the histamine. Then if we don’t do that, it’ll get stuck in the histamine receptor site. And then it’ll make something called, renin. Which will cause angiotensinogen to turn into angiotensin. One, that turns into angiotensin II,And that’s where people make aldosterone, where they’ll get the, The swollen ankles and high blood pressure. But interestingly, there’s an enzyme called ACE2, that takes this guy and turns it into angiotensin 1-7, Which is anti-inflammatory and also inhibits… TNFA. Now, you can have weakness on ACE2, But… and anybody’s saying, that sounds familiar? Dr. Deb Muth 00:52:25 That’s where COVID comes in, using ACE2. Bob Miller 00:52:28 And now we just found there’s literature that if you get COVID long enough, it can actually make ACE2 not be able to work as well. So look what it does. It comes down here, stimulates the NADPH oxidase, More superoxide. More peroxynitrite. And we’re on a cycle here. We’ve actually named this the Home Cycle Hypothesis, the proposed feed-forward loop. That just keeps feeding on itself. All being caused by… Primarily, The environmental factors. But hitting those who have genetic weakness the hardest. That’s why. Dr. Deb Muth 00:53:08 To the people. Bob Miller 00:53:09 Don’t live in a moldy house. One person is sick as can be, and the other person says, well, you must be imagining things, because I don’t feel anything. Dr. Deb Muth Yeah. Same thing with long haul, right? Two people can both get sick, one gets sick and never seems to recover, and somebody else gets sick, and they have absolutely no problems with it at all. Bob Miller 00:53:30 Sure. Well, think about it, if you get COVID, and ACE2 is weak, and some of this other stuff is going on. This thing just starts feeding upon itself. Dr. Deb Muth 00:53:38 Keep creating more inflammation, more complications, nothing’s calming down. Bob Miller 00:53:43 Yeah. Now, you, you ask about, MTHFR. So, this is the, this is the, the software called Functional Genomic Analysis. There’s a demo report we have. So, let’s talk a little bit about, MTHFR. So, we actually have a map called a methylation map. Now, what happens is, when you do your saliva test, you, you know, you spit, you put some saliva. in a collection kit, goes to a lab, takes out the DNA data, sends it to the computer, and now you can actually see it visually. Okay. So, it’s gonna take a second for this, data to load up, it’s, and each of these Circles, each of these ovals, is an enzyme. And the data gets loaded up to see where it is. So, until it gets loaded up here, I didn’t preload this. There it goes. So… The primary thing about methylation is There’s a nasty substance called homocysteine that, if it’s too high, can really be detrimental. The body takes methylfolate, and combines with methyl B12, To bring this back up to methionine. And then through the MAT genes, we make SAMI, S-adml methionine. Which is involved in so many processes. Then after it does its thing, it turns back into homocysteine. And this thing needs to keep spinning around. That’s why, you know, it’s a good idea to keep homocysteine at, do you have a number that you’d like? 7, 8? What do you like for a number? Dr. Deb Muth 00:55:24 Yeah, I like mine below 7. Bob Miller 00:55:26 Yeah. So if the homocysteine goes too high. It, caused all kinds of problems. So, here’s where you ask about the MTHFR. So, here you can see on this individual. I click on MTHFR, and you can see it comes up here, here’s the C677. And you can see here where it says, variants. I’ll… I’ll draw in case somebody’s having a hard time seeing that. So, you can see there’s nothing in there. That means there’s no genetic mutations. If one parent would have given a mutation, there’d be a 1. If both parents did, there’d be a 2. Now, here’s why Yes, methylation is important, I’m not saying it isn’t important, but look at this MTHFRC677. In my software. Only 42.5% of the population does not have a mutation. 44.7% have won. 12.9 have 2. So, this isn’t some rare, oh my god, I’m gonna die… Kind of thing, yeah. Dr. Deb Muth 00:56:27 Right. Bob Miller 00:56:28 So, And then what happens is that, and again, I’m not dismissing methylation, I… we could do a whole show on methylation. Bob Miller 00:56:36 get it. But I think that what people are doing is they’re, they’re learning about MTHFR, they get it measured, they panic. They start taking massive amounts of methylfolate, which many times is to their detriment. Dr. Deb Muth 00:56:50 Well, it’s… and isn’t it true, too, with MTHFR, like, you have to also look at MTR, MTRR, and the more we stack up of those, the more complicated than MTHFR can be. It’s not… it’s not as simple as just saying MTHFR 677 versus 1298. It’s more complex than that, kind of like what you’ve already shown with some of the other things. There’s more to it than just that one little sliver. Bob Miller 00:57:17 Oh, sure, well, let’s take a look. So, remember I said there’s a cofactor? One of the cofactors is called FAD. Just a Bob Miller observation, that’s all. But when people have trouble with their riboflavin and they don’t have enough FAD, They’re doing much worse than people who have just a C677. So, right here, you could have perfect C677th. And if you don’t have the cofactor, it’s not gonna work, okay? Dr. Deb Muth 00:57:48 And as you said, there’s an MTR enzyme. Bob Miller 00:57:51 that takes methylfolate and methyl B12, to spin it around. So, here on this individual. here’s your… here’s your B vitamins, or I’m sorry, your B12s. There’s an enzyme called TCN1 that takes it from the stomach into the blood. Then there’s other enzymes that take it from the blood into the tissue. And if you’re having trouble here. Well, then you’re not going to have this working, so… Even if you don’t have MTHFR, And you have MTR, like this, no, I’m sorry, this person doesn’t. But they have the MTRR, and then they don’t have enough B12, this isn’t gonna work, aside from that. And then there’s a middle pathway. And then there’s enzymes called the MAT1. they take the methionine to the salmon. If that’s not working, we stick… we get stuck in methionine. So, it’s, it’s not just an MTHFR. And then, one of the things that people forget about. is through these CBS enzymes and CTH, We make cysteine, which is needed to make glutathione. The master antioxidant. So, it really is that… I call it the, The 3D chess game played underwater. Dr. Deb Muth 00:59:07 It really is. I mean, I see people who have CVS, COMT, glutathione, MGHFR genes. And some of them function just fine. Like, they have Like, I look at this person and I’m like, oh my gosh, I don’t know how they’re functioning because they’re double mutated on so many pathways, but yet they don’t have a lot of symptoms, they don’t have a lot of complications. Somehow their body has figured out a way to adapt to what it has so it can stay alive and it can function at a high functioning level. Bob Miller 00:59:36 Yeah, and they may be, you know, eating right? Yeah. Staying out of a moldy house. reducing stress. So, it’s diet, it’s stress, it’s genetics, environmental factors. So, yeah, we can’t just say somebody’s gonna be good or somebody’s gonna be bad. You know, some people get scared, oh, I got all these, it’s like, well… Bob Miller 00:59:56 Are you living in a moldy house? You know, and if you live in a moldy house and your glucuronidation pathway doesn’t do well, or if you’re, you know, a smoker, or you’re constantly eating junk food, I mean, all. Bob Miller 01:00:07 things come together. Although, you know, when we focus on genetics, we’re well aware that this is just a piece of it. You know, you could have identical twins, Genetically, and if one… Is exposed to mold and smokes and drinks and stressed out. They’re gonna be a whole lot sicker than their sibling. Bob Miller 01:00:28 Yep. Dr. Deb Muth 01:00:29 Yeah, it’s that concept of taking twins, and one gets raced with one family, and one gets raced with another family, and they don’t have the same… problems that… that each other have, you know? It’s a very unique situation, we don’t think about that enough. Bob Miller 01:00:44 Alright, so again, genetics loads the gun, environment pulls the trigger. So, if you’ve got a loaded gun, but you don’t have the triggers, you’re okay. Dr. Deb Muth 01:00:53 Yeah. Bob Miller 01:00:54 Yeah. So, remember I said I was going to talk about NAD? So, here’s NAD, and what it does, it turns into NADH. And what NADH does, it, Comes down this pathway, what’s called the electron transport chain. And that makes your ATP, that’s your energy. So, if this wasn’t working, we wouldn’t be alive, because we wouldn’t have energy. So it donates an electron, that’s why it’s called electron transport chain. So, we need NAD, To make this, to make the energy. But remember I said that NQ01, this would probably be, like, on my top 10 list of… Bob Miller 01:01:36 Much more important than MTHFR. This one takes NADH back to NAD. If we’re stuck over here, We’re low in this NAD+, But what happens is, NQO1 also provides CoQ10. And CoQ10 Is what’s needed for the electron transport chain to flow. So if we get too many electrons up here. And they don’t turn them into energy. They make a nasty free radical called superoxide. Okay. Now, NAD plus also makes NADPH, And that is needed. Remember I said we need to recycle our antioxidants. So, if we have a problem with FAD from riboflavin. Yeah, we don’t have enough NADPH, Glutathione’s not getting recycled, and you’re gonna be inflamed. And you take glutathione, you’ll feel worse. There’s another enzyme called thimoredoxin. Same thing, needs NADPH and FAD. And same way with your nitric oxide, there’s an enzyme called NOS3, That makes the nitric oxide that dilates your blood vessels. And if we don’t have enough NADPH or fat, You’re gonna make superoxide. Rather than nitric oxide. Now, remember

You've increased estrogen.You've supported the gut.You've cleaned up the protocol.And… she's still dealing with dryness. recurrent UTIs., and discomfort that keeps coming back.At some point, it stops being a hormone conversation.When labs look “fine” and symptoms persist, adding more support doesn't fix the problem. It just exposes it.In this episode, Dr. Ritamarie sits down with Dr. Anna Cabeca to look at a pattern that gets missed in conventional and functional care: the vaginal microbiome.This is NOT a side topic but a primary driver.They walk through what happens when Lactobacillus balance is disrupted, why vaginal pH shifts matter more than most practitioners realize, and how these changes can create symptoms that look hormonal but don't respond to hormone-based approaches.You'll start to see why some cases don't resolve…and what to look at next when they don't.What's Inside This Episode?Normal estrogen… but persistent drynessWhy UTIs keep coming backWhen pH—not hormones—is the issueThe key Lactobacillus strains that matterHow antibiotics and HRT disrupt the ecosystemUrgency and leakage that aren't a bladder problemThe link to fertility, aging, and tissue healthWhy systemic protocols fail when the issue is localResources and LinksDownload the Full TranscriptDownload our FREE Metabolic Health Guide here. Join the Next-Level Health Practitioner Facebook group here for free resources and community supportVisit INEMethod.com for advanced health practitioner training and tools to elevate your clinical skills and grow your practice by getting life-changing results. Check out other podcast episodes hereDr Anna's Resources and LinksDr Anna's Website: https://drannacabeca.comCheck out Dr Anna's productsFind her on Social Media FacebookYouTube: The Girlfriend Doctor: TikTokPodcast Labs & Testing Mentioned in This EpisodeThese tools go beyond traditional testing (HPV, chlamydia, gonorrhea, trichomonas) and help assess overall vaginal microbiome balance, including beneficial Lactobacillus species.MDL (Medical Diagnostic Laboratories) - Vaginal testing that includes both pathogenic organisms and beneficial bacteriaBiomeFX Vaginal Microbiome Kit - Advanced microbiome analysis to assess vaginal bacterial balanceTiny Health Vaginal Microbiome Test - At-home testing option for evaluating vaginal microbial healthGuest BioAnna Cabeca, DO, OBGYN, FACOG, is best selling author of The Hormone Fix and Keto-Green 16 and MenuPause. Dr. Anna is triple-board certified and a fellow of gynecology and obstetrics, integrative medicine, and anti-aging and regenerative medicine. She holds special certifications in functional medicine, sexual health, and bioidentical hormone replacement therapy. She lectures frequently on those topics and shares the secret behind the ebb and flow of intimacy as she demystifies the fascinating hormonal changes over time. She will help you discover how the “love hormone”, Oxytocin can breathe life into your relationship, and how Cortisol can take it away - and how the delicate balancing act of those hormones can reignite your libido and support a healthy relationship, most importantly the one you have with yourself.She is sassy, blunt, speaks from the heart and has a wonderful sense of humor, and this is why we call her The Girlfriend Doctor, because everyone needs a friend like her! She has personally developed natural products to help women balance hormones and thrive through menopause including the highly acclaimed Julva® cream for the vulva and MightyMaca® Plus, a powerful superfood blend. She lives in Dallas with her daughters, horses and dogs.

This episode started with a question I get constantly. Why is my routine not working anymore? The products are good. The consistency is there. But the skin is not responding the way it used to. More dullness. More puffiness. More fine lines despite the retinol. Here is what most of the skincare conversation is missing: your skin is not a surface problem. It is an output. A real-time signal of what is happening inside your hormonal system. And your bloodwork is the decoder. In this episode, I walk through four specific lab markers that directly control what your menopause skin does: estrogen, free T3, cortisol, and ferritin. Each one maps to a skin symptom you are probably already seeing in the mirror. Dryness and collagen loss. Estrogen. Stubborn dullness that no exfoliant fixes. Free T3. Fine lines that retinol cannot hold. Cortisol. Dark circles that no eye cream touches. Ferritin. These are not random. They are specific. And once you know what to look for, you stop blaming your products and start asking better questions. Your hormones are the primer. Your products are the paint. Paint on an unprimed surface looks beautiful for a day and then lifts. That is exactly what is happening for a lot of women in menopause, and it has nothing to do with the products they chose. This episode is the overview. The in-depth version, with the specific markers to request, what optimal ranges look like for skin health, and how to build a recalibration protocol around your results, lives inside the Skin Scholar Society on Substack. The Skin Scholar Society is where I publish the research, the protocols, and the education that goes deeper than a single episode can hold. If you are ready to stop guessing and start working with your biology, that is the place to be.   Lindsey Holder is a Menopause Skin Specialist and Master Esthetician with 16+ years of clinical experience. She helps women in menopause recalibrate their skincare to restore firmness, clarity, and glow without Botox or fillers. Find her at lindseyholder.com and on Instagram @lindseyrholder.    Meta Description (150 characters): Your skincare is not failing. Your bloodwork might be. Menopause skin specialist Lindsey Holder breaks down what your labs are telling your skin. Slug: /bloodwork-menopause-skin-podcast Focus Keyword: menopause skin and bloodwork Tags: menopause skin, bloodwork, hormones and skin, menopause esthetician, Skin Scholar Society Resources  Join the Skin Scholar Society: HERE   Download my Free 7 Day Skincare Guide: HERE Listen to exclusive podcast content + download my FREE esthetician-led skincare app Apple iOS: HERE Google Play: HERE Favorite Skincare Products HERE

Dr. Paulo Porto de Melo é uma autoridade máxima e brutal quando o assunto é a máquina mais complexa do universo. Ex-major do Exército por 19 anos e pioneiro na introdução da neurocirurgia robótica no Brasil , ele carrega o privilégio de ter tocado e operado mais de 10.000 cérebros humanos. Neste episódio, ele deixa a linguagem corporativa morna de lado para escancarar os segredos de bastidores que determinam quem terá uma mente brilhante ou quem sofrerá um colapso cognitivo total nas próximas décadas. Prepare-se para descobrir a verdade oculta sobre a demência que começa a destruir seus neurônios 20 anos antes do primeiro sintoma aparecer. Dr. Paulo revela o perigo invisível por trás dos remédios para dormir , o impacto destrutivo da cafeína no cérebro , a farsa do açúcar que causa o "Diabetes Tipo 3" , e uma descoberta científica chocante: a comunicação quântica dos neurônios através de fótons de luz. Uma verdadeira aula de sobrevivência e alta performance biológica que vai redefinir o seu futuro.Patrocinador:Clinica RUV - Harmonização que respeita quem você é.https://www.instagram.com/dra.najlavicentini/Disponivel Também no Youtube:https://youtu.be/cOwuA8H2SLc00:00:00 - O perigo ético da Neuralink e os backdoors chips cerebrais. 00:05:30 - Como prevenir 45% das demências e blindar sua coluna contra hérnias. 00:08:20 - Diabetes Tipo 3: A falência energética e a fome celular dos neurônios. 00:14:00 - O chocante Estudo das Freiras: Caminhos alternativos e redundância cognitiva. 00:18:10 - Lipidômica: O teste definitivo da ponta do dedo para equilibrar sua membrana celular. 00:23:50 - O erro do prato brasileiro: A ordem que você come altera sua glicose em 70%. 00:25:20 - Jejun intermitente, autofagia e o sinal de qualidade para o corpo. 00:34:00 - A verdadeira arquitetura do sono e a redução de 60% dos neurônios. 00:36:10 - Por que os remédios para dormir são uma farsa que te deixa cansado. 00:41:30 - Cafeína e o receptor de Adenosina: O soco no queixo da sua energia. 00:47:40 - O erro fatal de tomar café imediatamente após acordar. 00:53:00 - O piano genético e como a atividade física afasta doenças crônicas. 01:00:00 - Cortisol, privação de sono militar e a técnica limite da CIA. 01:13:30 - Cérebro Quântico: A descoberta dos fótons de luz entre neurônios. 01:17:20 - O caso real do tumor que era um abscesso: O diagnóstico pelo cheiro. 01:20:00 - AVC Isquêmico vs Hemorrágico e os sinais de alerta definitivos. 01:52:00 - Como os restaurantes usam a neurociência e luzes amarelas para hackear sua fome. Siga a Dr. Paulo no Instagram:⁠https://www.instagram.com/ppmelo/Nos Siga:Marcelo Toledo: ⁠https://www.instagram.com/marcelotoledoInstagram: ⁠https://www.instagram.com/excepcionaispodcastTikTok: ⁠https://www.tiktok.com/@excepcionaispodcast

Here's the uncomfortable truth: forgiveness isn't primarily for the other person… it's for you. (Ugh, we know.) This week we explore what it might mean to stop letting a past wound have the final word over your present life.   LINKS: Book of Forgiving  |  Connect  |  YouTube  |  Coming Up TRANSCRIPT:   Retell from Freya's perspective — what was she feeling as Wally spoke? Name those feelings out loud and mark a stone with washable marker for each one as you name them: Angry. (mark) Sad. (mark) Embarrassed. (mark) Lonely. (mark) "Look at this stone now. Pretty marked up. That's what it looks like when we've been carrying a lot." Watch the video — Freya bringing Wally back, returning him to their community. Unpack: What did Freya choose? She didn't pretend it didn't happen. She didn't say it was okay. But she chose something — and whatever she chose, it changed things. We're going to do something with these stones in a little while. Hold onto yours. Hand out stones and washable markers to kids. Send them back to seats to mark up their stones and work on kids Sunday Papers. Adults — I want to talk to you now. But kids, you're welcome to listen in! Where We've Been Brief catch-up for anyone new or returning: We're in The Book of Forgiving — drawing from Desmond and Mpho Tutu's framework for how forgiveness actually works. The Fourfold Path: Tell the Story → Name the Hurt → Grant Forgiveness → Renew or Release the Relationship. In the first week: We told our stories. Last week: We named the hurt: the feelings underneath the facts. Today: we take the hardest step. We talk about what it actually means to grant forgiveness. The Uncomfortable Truth Here's where we have to say something that cuts against almost everything our culture tells us about forgiveness: Forgiveness is not primarily for the other person. It's FOR YOU. (ugh, I know.) That feels wrong at first. It can even feel like a betrayal of the seriousness of what was done. If I forgive, doesn't that let them off the hook? No. And we'll come back to that. But first… someone wise once put it this way: "Forgiveness is the act of giving up all hope of a better past." Sit with that for a second. Forgiveness isn't giving up on justice. Or saying that what happened was okay. Its not pretending it didn't happen. But instead, forgiveness is releasing the white-knuckled grip on the belief (conscious or not) that somehow, if we hold on tight enough, stay angry enough, rehearse it enough, the past will change. It won't. And the holding on costs us. What the Holding Costs Us This isn't just spiritual intuition. There's reliable research proving it. When we hold onto unresolved hurt— ruminating, replaying, rehearsing— our bodies respond as if the threat is still happening. Cortisol stays elevated. The nervous system stays on alert. Over time this contributes to measurable increases in anxiety, depression, cardiovascular stress, and immune suppression, among other truly serious health issues. We are not built to carry this indefinitely. The body keeps the score, and it charges interest. If we want to “make America healthy again,” it turns out denial just isn't actually gonna do it. Developing cultural practices around forgiving and healing, though? That's the ticket. The Tutus frame the alternative this way: in the Revenge Cycle, we reject our pain and try to make it go away by hurting the person who hurt us. In the Forgiveness Cycle, we face our pain. We don't deny it or minimize it. And we choose to move toward healing instead. The Tutus: "In the Revenge Cycle, we reject our pain and suffering and believe that by hurting the person who hurt us our pain will go away." It doesn't. It never has. It simply multiplies…  There's all sorts of bumper sticker opportunities here: “hurt people hurt people” The trap: waiting to forgive until the other person apologizes. They may never. They might not even know or appreciate what they did. They may never. But if your freedom is contingent on their remorse, they hold a lot of unearned power over you. It lives rent-free in your head. What Forgiveness is Not… Clearing the Ground Again Because this step gets misused more than any other, it's worth naming clearly what granting forgiveness does NOT mean (this is a real “sorry not sorry” moment for repeating this pretty much every week, but we're untangling a real knot here): It does not mean what was done to you was okay. It does not mean you forget. It does not mean you reconcile. (Forgiveness and reconciliation are separate acts — we'll talk about that next week.) It does not mean the other person deserves it or has earned it. It does not mean you have to tell them. The Tutus: "Forgiveness is a choice. Forgiving is how we move from victim to hero in our own story."  And honestly, I love being the hero of my own story, but when it comes to pain, I don't need to be a hero, I just want agency… And this is key: you can pursue justice and forgiveness at the same time. One does not cancel the other. You can hold someone accountable AND release the stranglehold their actions have on your inner life. These are not in competition. It's not one or the other. GRANTING FORGIVENESS… WHAT IT ACTUALLY IS So what IS it then? At its core, the Tutus describe granting forgiveness as an act of RECLAIMING YOUR HUMANITY— and in doing so, recognizing the humanity of the person who hurt you. Not excusing them. Not elevating them. But refusing to reduce either of you to the worst moment between you. This is where the Tutu framework gets genuinely hard. Because recognizing the humanity of someone who hurt you; someone who may have done something terrible… it can feel like a betrayal. But here's what Desmond Tutu learned in the shadow of apartheid, sitting across from perpetrators of atrocity: to call someone a monster is actually to let them OFF THE HOOK. Monsters can't help what they do. Humans can. Naming someone's humanity–  their capacity to choose, and to have chosen badly— is what makes them accountable. And it's what releases you from defining yourself by what they did. The Tutus write: "We know we are healing when we are able to tell a new story." Not a story in which the wound never happened. A story in which the wound is no longer the main character. This is what it looks like in practice: You stop organizing your life around the person who hurt you. You stop letting their actions have veto power over your contentment or joy, your relationships, or your sense of self. You begin— slowly, imperfectly— to live forward instead of backward. It starts feeling less like a feeling and more like a direction. You turn your face toward something other than the wound. Again. And again. That's the practice. Kids Back Up to Close Invite kids back up… talk about those marks on stones. Forgiveness is the process of remembering that “I am not the things that happened to me.” I am not this mark… or that mark…” Those things hurt, and I have feelings about the person that did that thing to me… but I'm going to choose to be confident in who I am, how I treat others, and I get to make choices about my own self… that person doesn't get to make decisions about me for me.” Dip stones in water.  We'll talk more about what happens in our relationships next week, and we'll learn about how Wally & Freya figured that out for themselves and their community of friends. Closing Invitation Now we do something together. "If you've been marking up your stone — kids, adults, anyone — I want to invite you to come forward in a moment and dip it in the water." Brief explanation of what this means and doesn't mean: "This isn't a magic trick. Dipping your stone doesn't mean you're over it. It doesn't mean what happened was okay. It doesn't mean you've completed something." "It's a gesture. A small act of intention. You're saying: I don't want to be defined by this forever. I want to begin to get free." "The Tutus write that we wash the stone — and it's a cleansing, not an erasing. The stone is still the stone. You are still you. But something has been released." Invite people forward — quietly, no pressure, in their own time — to dip their stones in water. Let the room breathe. Music underneath if possible. Closing Next week: reconciliation. What does it actually look like to renew or release a relationship? What's required? What's possible? Come back. A simple benediction: You are more than what was done to you. Go live like it.  

Amanda Decker is a family nurse practitioner, metabolic health practitioner, and founder of Clear Path Medical. After overcoming her own struggles with weight and chronic psoriasis, she shifted her focus from conventional primary care to nutrition and lifestyle medicine. Today, Amanda helps patients address the root causes of chronic disease through evidence-based approaches centered on metabolic health, low-carb nutrition, and sustainable lifestyle change. With nearly two decades of clinical experience and multiple advanced certifications in obesity medicine, ketogenic nutrition, and metabolic health, she is passionate about empowering people to take control of their health and transform their lives. In this episode, Dr. Brian and Amanda talk about… (00:00) Intro (05:54) Cholesterol and cardiovascular health (09:50) Amanda's experience switching to and working in a DPC practice (11:54) Triglycerides and coffee (13:57) Stress, community, and working in the medical field (19:11) Amanda's upcoming Low Carb for Better Health conference (link below) (22:55) Bio-individuality and the proper human diet (25:54) The speaker line-up at the upcoming Low Carb for Better Health conference (link below) (31:29) Gut health, carnivore diets, and holistic health (39:45) Gut health and fatty liver disease (40:34) Health outliers and food noise (48:18) Cortisol and Cushing's Disease (01:01:50) Outro For more information, please see the links below. Thank you for listening! Links: Please consider supporting us on Patreon: https://www.lowcarbmd.com/   Amanda Decker: Website: https://www.clearpathmedical.net/ X: https://x.com/deckerlesscarbs?lang=en IG: https://www.instagram.com/deckerlesscarbs/?hl=en FB: https://www.facebook.com/deckerlesscarbs/?ref=NONE_xav_ig_profile_page_web# Low Carb for Better Health: https://events.humanitix.com/low-carb-for-better-health Dr. Brian Lenzkes:  Website: https://arizonametabolichealth.com/ Twitter: https://twitter.com/BrianLenzkes?ref_src=twsrc^google|twcamp^serp|twgr^author Dr. Tro Kalayjian:  Website: https://toward.health Twitter: https://twitter.com/DoctorTro IG: https://www.instagram.com/doctortro/ Toward Health App Join a growing community of individuals who are improving their metabolic health; together.  Get started at your own pace with a self-guided curriculum developed by Dr. Tro and his care team, community chat, weekly meetings, courses, challenges, message boards and more.  Apple: https://apps.apple.com/us/app/doctor-tro/id1588693888  Google: https://play.google.com/store/apps/details?id=uk.co.disciplemedia.doctortro&hl=en_US&gl=US Learn more: https://toward.health/community/

Esther Blum, integrative dietitian and menopause expert, unpacks the estrogen supply chain crisis, leaving women without basic hormone care, while there are 25 erectile dysfunction medications on the market with zero shortages. But the conversation goes deeper: if your gut and liver detox pathways aren't functioning first, HRT may not work the way you're hoping. Esther breaks down the gut-liver-hormone axis, explains why 70% of women aren't detoxing their hormones properly, and makes the case for eating more — not less — in midlife. Plus: testosterone as the missing menopause hormone, why carbs at dinner might be the key to sleeping through the night, and why the zero F's era is the best-kept secret of menopause.

A dysregulated nervous system will stall body recomposition no matter how dialed the nutrition is or how consistent the training is. Inside today's episode, I dig into trauma as a physiological variable rather than a soft emotional topic, and why most coaching certifications skip this conversation entirely. I break down the autonomic nervous system and HPA axis interplay, the two nervous system presentations , and why the cortisol literature looked contradictory for years.Topics discussed: - Trauma as a Spectrum- Autonomic Nervous System Dysregulation- HPA Axis and Cortisol Output- Sympathetic Dominance Presentation- The Dissociative Subtype- Cortisol Patterns Over Time- Childhood vs Adult Trauma- Inverted Diurnal Rhythm- Lifestyle and Clinical Interventions- The Coach's Role and Scope---------- ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠My Live Program for Coaches: The Functional Nutrition and Metabolism Specialization ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠www.metabolismschool.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠---------- [Free] Metabolism School 101: The Video Series⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠http://www.metabolismschool.com/metabolism-101⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠----------Subscribe to My Youtube Channel: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://youtube.com/@sammillerscience?si=s1jcR6Im4GDHbw_1⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠----------⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Grab a Copy of My New Book - Metabolism Made Simple⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠---------- Stay Connected: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Instagram: @sammillerscience⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Youtube: SamMillerScience⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Facebook: The Nutrition Coaching Collaborative Community⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠TikTok: @sammillerscience⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠----------“This Podcast is for general informational purposes only and does not constitute the practice of medicine, nursing or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast and the show notes or the reliance on the information provided is to be done at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment and is for educational purposes only. Always consult your physician before beginning any exercise program and users should not disregard, or delay in obtaining, medical advice for any medical condition they may have and should seek the assistance of their health care professionals for any such conditions. By accessing this Podcast, the listener acknowledges that the entire contents and design of this Podcast, are the property of Oracle Athletic Science LLC, or used by Oracle Athletic Science LLC with permission, and are protected under U.S. and international copyright and trademark laws. Except as otherwise provided herein, users of this Podcast may save and use information contained in the Podcast only for personal or other non-commercial, educational purposes. No other use, including, without limitation, reproduction, retransmission or editing, of this Podcast may be made without the prior written permission of Oracle Athletic Science LLC, which may be requested by contacting the Oracle Athletic Science LLC by email at ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠operations⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@sammillerscience.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. By accessing this Podcast, the listener acknowledges that Oracle Athletic Science LLC makes no warranty, guarantee, or representation as to the accuracy or sufficiency of the information featured in this Podcast."

The Hidden Causes of Brain Fog, Anxiety, and Chronic Illness: Mold, Parasites, Histamine, and Low Cortisol If you're exhausted, inflamed, and can't figure out why, the answer might be hiding in your histamine, your hormones, your home, or something living inside you that your doctor will never test for. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Dr. Jessica Peatross, a former hospitalist turned functional medicine powerhouse who walked away from a conventional medical career after discovering that 90% of disease traces back to lifestyle, environment, and the toxins most doctors ignore. After graduating magna cum laude and earning her medical degree from the University of Louisville, Dr. Jess pursued training in functional medicine, nutrigenomics, and alternative therapies, and now helps thousands of patients reverse chronic illness through her KillBindSweat method and WellnessPlus app. She is also the formulator and CMO of Aegis Formulas and a leading voice at international health conferences. If chronic illness, mold toxicity, or hormonal chaos is on your radar, she is the person you want in your corner. Together, Dave and Dr. Jess go deep into the hidden drivers of mystery symptoms that functional medicine is finally starting to crack open. They cover why low cortisol is more dangerous than high cortisol, how histamine and mast cell activation syndrome explain everything from anxiety and brain fog to endometriosis and POTS, and why most "Lyme disease" is actually undiagnosed mold toxicity. They also break down the parasite epidemic hiding in plain sight across the United States, the B vitamin mistake making millions of people sicker, and why your metabolism, mitochondria, and mental health are all downstream of things your standard lab panel will never catch. This episode also gets into the real story behind Dr. Jess surrendering her California medical license rather than comply with a system she believed was working against patient health. Her firsthand account of the medical board process is something every person who cares about medical freedom needs to hear. You'll Learn: Why everyone who is chronically sick has a low cortisol awakening response and what to do about it How histamine drives anxiety, racing thoughts, palpitations, bloating, skin issues, and hormonal chaos Why 90% of people diagnosed with Lyme disease actually have toxic mold and how to test for both The parasite epidemic in the U.S. and why standard testing misses most of it How the spike protein reactivates dormant viruses and feeds the histamine loop behind long COVID Why synthetic B6 causes the very neuropathy it is supposed to fix, and what to take instead The cortisol, adrenaline, and blood pressure connection that explains "wired but tired" How progesterone stabilizes mast cells and why estrogen dominance fuels inflammation and reactivity Why Dave Asprey uses low-dose cortisol, dexamethasone, and modafinil as part of his daily performance stack The mold binders that actually work, and which popular ones can harm hypermobile people How nicotine at low doses blocks spike protein from ACE2 receptors and protects the brain What the MTHFR gene, methylation, and folic acid have to do with breast cancer, depression, and estrogen detox Thank you to our sponsors! - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE - KILLSwitch | If you're ready for the best sleep of your life, order now at https://www.switchsupplements.com/and use code DAVE for 20% off - Calroy | Go to Calroy.com/DAVE for exclusive discounts on Arterosil HP, Vascanox HP and all Calroy products. - Cowboy Colostrum | Get your gut right by going to cowboycolostrum.com/asprey for 25% off of your entire order. -Amp | If you're ready to make fitness fit into your life, go to amp.ai to check it outDave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Dr. Jessica Peatross, functional medicine, mast cell activation syndrome, histamine intolerance, long COVID brain fog, mold toxicity, chronic Lyme disease, parasite testing, low cortisol, cortisol awakening response, MTHFR methylation, B6 toxicity, P5P, folinic acid, estrogen dominance, progesterone therapy, spike protein reactivation, Epstein-Barr reactivation, POTS, wired but tired, Kill Bind Sweat, WellnessPlus, vaccine exemptions, mold binders, nicotine ACE2, adrenal insufficiency, RCCX gene Resources: • Go to https://drjessmd.com/ and use code ‘DRJESS' at checkout • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 00:33 – Releasing Medical License 03:21 – Chronic Illness Root Causes 05:00 – Hospital Nutrition 08:11 – Dave's Health History 10:22 – Parasites 20:02 – Nicotine 23:19 – Low Blood Pressure & Minerals 28:09 – B Vitamins & Methylation 33:45 – Autism & Genetics 40:13 – Toxic Mold 43:11 – ADHD Misdiagnosis 48:27 – Histamine & Mast Cells 50:56 – Long COVID & Spike Protein 58:56 – Cortisol 1:03:56 – Lyme Disease 1:09:58 – Mold Testing & Binders 1:16:37 – Closing See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.