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Matters Microbial #62: Should I Stay, or Should I Go—How Bacteriophage are Released from Host Cells October 23, 2024 Today, Dr. Jolene Ramsey, of the Biology Department of Texas A&M University and Affiliate of the Center for Phage Technology, joins the #QualityQuorum to discuss how bacteriophages release themselves from host cells, her efforts to teach students to work with the primary literature, and her own path to the microbial sciences. Host: Mark O. Martin Guest: Jolene Ramsey Subscribe: Apple Podcasts, Spotify Become a patron of Matters Microbial! Links for this episode A truly wonderful reminder video about bacteriophages. A link with a 3D printer design of capsid model pieces (personally, I am really interested in making one of these!). A video demonstrating how the capsid model pieces self assemble—something like real viruses can? An essential book about bacteriophage authored by my late friend Merry Youle. A fine book describing how bacteriophages can be used to fight bacterial diseases. This “first person” book by #MattersMicrobial podcast guest Steffanie Strathdee about how she was able to use bacteriophages to save her husband's life is a must read. A link to the Citizen's Phage Library. A link to the truly fabulous (yes, I am jealous I am not part of this program) CURE program SEA-PHAGES and SEA-GENES for undergraduate students. A remarkable illustration of T4 bacteriophage bursting from host cells by the scientist-artist David Goodsell. The organization that designed Dr. Ramsey's laboratory logo. A link to the Clinical Genome Curation for Human Genes. A link to the CACAO website for biocuration competition. A recent Ramsey lab mini-review on phage classification. A link to the Center for Phage Technology. The Ramsey lab Instagram page. The Ramsey lab YouTube channel. Dr. Ramsey's laboratory website. Dr. Ramsey's faculty website. Intro music is by Reber Clark Send your questions and comments to mattersmicrobial@gmail.com
Melvyn Bragg and guests discuss the most abundant lifeform on Earth: the viruses that 'eat' bacteria. Early in the 20th century, scientists noticed that something in their Petri dishes was making bacteria disappear and they called these bacteriophages, things that eat bacteria. From studying these phages, it soon became clear that they offered countless real or potential benefits for understanding our world, from the tracking of diseases to helping unlock the secrets of DNA to treatments for long term bacterial infections. With further research, they could be an answer to the growing problem of antibiotic resistance.With Martha Clokie Director for the Centre for Phage Research and Professor of Microbiology at the University of LeicesterJames Ebdon Professor of Environmental Microbiology at the University of BrightonAnd Claas Kirchhelle Historian and Chargé de Recherche at the French National Institute of Health and Medical Research's CERMES3 Unit in Paris.Producer: Simon TillotsonIn Our Time is a BBC Studios Audio ProductionReading list: James Ebdon, ‘Tackling sources of contamination in water: The age of phage' (Microbiologist, Society for Applied Microbiology, Vol 20.1, 2022) Thomas Häusler, Viruses vs. Superbugs: A Solution to the Antibiotics Crisis? (Palgrave Macmillan, 2006)Tom Ireland, The Good Virus: The Untold Story of Phages: The Mysterious Microbes that Rule Our World, Shape Our Health and Can Save Our Future (Hodder Press, 2024)Claas Kirchhelle and Charlotte Kirchhelle, ‘Northern Normal–Laboratory Networks, Microbial Culture Collections, and Taxonomies of Power (1939-2000)' (SocArXiv Papers, 2024) Dmitriy Myelnikov, ‘An alternative cure: the adoption and survival of bacteriophage therapy in the USSR, 1922–1955' (Journal of the History of Medicine and Allied Sciences 73, no. 4, 2018)Forest Rohwer, Merry Youle, Heather Maughan and Nao Hisakawa, Life in our Phage World: A Centennial Field Guide to Earth's most Diverse Inhabitants (Wholon, 2014)Steffanie Strathdee and Thomas Patterson (2019) The Perfect Predator: A Scientist's Race to Save Her Husband from a Deadly Superbug: A Memoir (Hachette Books, 2020)William C. Summers, Félix d`Herelle and the Origins of Molecular Biology (Yale University Press, 1999)William C. Summers, The American Phage Group: Founders of Molecular Biology (University Press, 2023)
I had a profound and heart-wrenching conversation with renowned infectious disease specialist Steffanie Strathdee. Steffanie is Canadian-born and named by Time Magazine as one of the 50 most influential people in healthcare. She has written a book titled The Perfect Predator. A Scientists race to save her Husband from a Deadly Superbug. Steffanie's story unfolds like a gripping thriller. On holiday in Egypt, with her husband Tom, a deadly Superbug hijacks his body and it has Superpowers. It steals genes from other bacteria and the environment to resist antibiotics. This Superbug isn't an anamoloy. 5 million people will die from these types of infections in 2024. By 2050, that number is predicted to be 10 million. Why? The misuse and overuse of antibiotics in medicine and animal husbandry. Tom is airlifted to Germany, where the doctors aren't only perplexed, they are terrified as in the past this Superbog has shut down entire hospitals. They can do nothing, so Tom is Medevaced to the US. Fighting for his life, his organs shutting down, Tom is running out of time. Steffanie is desperate. She sees a psyche, hears about a century-old forgotten cure developed by a French Canadian but must enlist a dream team to try to save his life. What they uncover might save millions of lives, including yours and mine. To buy Steffanie and Tom's Book: The Perfect Predator. A Scientist's Race to Save Her Husband from a Deadly Superbug. https://www.amazon.com/Perfect-Predator-Scientists-Husband-Superbug/dp/0316418080 Time Code: 00:00 I introduce Stephanie Strathdee, An influential Scientist in infectious diseases. 04:48 Super Bugs are a Global Issue - 5 million deaths 05:57 Why aren't antibiotics working the way they used to? 07:54 Global agencies urge action and lack accountability measures. 10:41 The Perfect Vacation turns on a dime - A Super Bug invades Tom's body 12:40 Epidemiologist in Germany shocked by a deadly antibiotic-resistant bacterium. 15:38 Germans send Tom to the United States; nothing they can do 18:02 Tom is dying; a squeeze from his hand changes everything 24:57 Phage could be the cure but against all odds 29:48 Phage preparation to remove toxic bacteria so treatment doesn't kill Tom 30:52 Steffanie must make a life-and-death decision 34:07 Tom treasures life and moments together; phage therapy is a last attempt. 36:18 Phage saved Tom; can it save you and me? 37:48 Was this a miracle? 39:51 Tony's Three Takeaways 41:51 Tony's holiday message to you 43:50 Tony's Holiday Message
Today Dr. Steffanie Strathdee, Associate Dean of Global Health Sciences at UC San Diego and Co-Director at the Center for Innovative Phage Applications and Therapeutics, will chat with us about how bacteriophages—viruses that attack bacteria—changed her life and are becoming part of our future. Host: Mark O. Martin Guest: Steffanie Strathdee Subscribe: Apple Podcasts, Spotify Become a patron of Matters Microbial! Links for this episode A fun video about bacteriophages. A pretty solid overview about bacteriophages. An article about the history of bacteriophages. An article about a truly prophetic book—“Arrowsmith”--- from 1925, by Sinclair Lewis, about using bacteriophages to fight disease. A wonderful TED talk about the rise of antibiotic resistant pathogens by Maryn McKenna. A nice overview of ESKAPE pathogens and antimicrobial resistance. A link to a recent talk given by Dr. Strathdee. A link to Dr. Strathdee's recent book, “The Perfect Predator.” A super recent and quite wonderful review article about phage therapy by Dr. Strathdee. The SEAPHAGES program (which I always wanted to be part of!!) Ry Young's laboratory website. Dr. Strathdee's faculty website. Dr. Strathdee's Wikipedia page! A link to the website of the Center for Innovative Phage Applications and Therapeutics (IPATH). Intro music is by Reber Clark Send your questions and comments to mattersmicrobial@gmail.com
In recognition of World AMR Awareness Week (WAAW), Steffanie Strathdee, Associate Dean of Global Health Sciences and Harold Simon Distinguished Professor in the Department of Medicine at the University of California San Diego School of Medicine, joined the AMR Action Podcast to share the story of how her husband's case of “Iraqibacter” led her to find a phage therapy that saved his life. Steffanie also shares her thoughts on opportunities for Canada to lead on AMR innovation, and the resources and regulations required to make phage therapy available as an alternative to antimicrobials in health settings across the United States, Canada and the world.Read Steffanie's book: The Perfect Predator: A Scientist's Race to Save Her Husband from a Deadly Superbug: A MemoirLearn more about Phage Canada.
Antimicrobial resistance killed over a million people in 2019. That figure is expected to rise to ten million by 2050. Antibiotics remain vital to modern medicine, but this hidden pandemic of drug-resistant superbugs is driving scientists to explore possible alternatives. One type of therapy in particular is attracting serious scientific interest: bacteriophages. Phages are viruses that can destroy bacteria. In the 1920s, phage therapies were used widely against infections, but much of the world abandoned the idea following the discovery of penicillin. Some parts of the former Soviet Union, though, have continued to use phage therapies. What can governments and international companies learn from this medicine?Gilead Amit, The Economist's science correspondent, travels to the Eliava Institute in Tbilisi, Georgia to find out how phage therapies have been used there over the last century. He speaks to the director, Mzia Kutateladze, head of phage production, Vakho Pavlenishvili, and from the therapy centre: Davit Sturia, Lia Nadareishvili and Lana Abesadze. Barry Rud, a Canadian patient attending the clinic, discusses his experience. Steffanie Strathdee, who leads phage research at the University of California, San Diego, explains the renewed international interest in bacteriophages. Alok Jha, The Economist's science and technology editor, hosts.We would love to hear from you. Please fill out our listener survey at economist.com/babbagesurvey.The Economist is also seeking applications for the 2023 Richard Casement internship. The successful candidate will spend three months with us in London writing about science and technology. More details here: economist.com/casement2023.For full access to The Economist's print, digital and audio editions subscribe at economist.com/podcastoffer and sign up for our weekly science newsletter at economist.com/simplyscience. Hosted on Acast. See acast.com/privacy for more information.
Antimicrobial resistance killed over a million people in 2019. That figure is expected to rise to ten million by 2050. Antibiotics remain vital to modern medicine, but this hidden pandemic of drug-resistant superbugs is driving scientists to explore possible alternatives. One type of therapy in particular is attracting serious scientific interest: bacteriophages. Phages are viruses that can destroy bacteria. In the 1920s, phage therapies were used widely against infections, but much of the world abandoned the idea following the discovery of penicillin. Some parts of the former Soviet Union, though, have continued to use phage therapies. What can governments and international companies learn from this medicine?Gilead Amit, The Economist's science correspondent, travels to the Eliava Institute in Tbilisi, Georgia to find out how phage therapies have been used there over the last century. He speaks to the director, Mzia Kutateladze, head of phage production, Vakho Pavlenishvili, and from the therapy centre: Davit Sturia, Lia Nadareishvili and Lana Abesadze. Barry Rud, a Canadian patient attending the clinic, discusses his experience. Steffanie Strathdee, who leads phage research at the University of California, San Diego, explains the renewed international interest in bacteriophages. Alok Jha, The Economist's science and technology editor, hosts.We would love to hear from you. Please fill out our listener survey at economist.com/babbagesurvey.The Economist is also seeking applications for the 2023 Richard Casement internship. The successful candidate will spend three months with us in London writing about science and technology. More details here: economist.com/casement2023.For full access to The Economist's print, digital and audio editions subscribe at economist.com/podcastoffer and sign up for our weekly science newsletter at economist.com/simplyscience. Hosted on Acast. See acast.com/privacy for more information.
As the world continues to evolve toward advances in technology, the sciences, and globalization, it's important to reflect on the real-world gains of such progressions as well as the future opportunities that exist. In the case of this episode, the gains are associated with saving lives and combating the emerging threat of antimicrobial resistance and antibiotic resistant infections, which have been deemed by The World Health Organization as one of the top 10 global public health threats facing humanity. This episode is Part 2 of a series that focuses on AMR and the innovations in science and technology that are helping to tackle the challenge. The episode also points toward the connection between the issues of climate change and AMR as well as the opportunities to combine forces and develop collaborative efforts in addressing these threats. The episode digs deeper into innovations happening within healthcare to defeat superbugs as shared from the perspective of this episode's guest, Dr. Steffanie Strathdee, who is an Epidemiologist, Distinguished Professor, Global health solution-seeker, TEDx speaker, and Author of The Perfect Predator, a memoir of her effort to save her husband's life and the discovery of a forgotten cure that has the potential to save millions more. Steffanie also serves as Co-Director of the Center for Innovative Phage Applications & Therapeutics at the University of California, San Diego, School of Medicine as well as the Associate Dean of Global Health Sciences. Other topics range from the importance of advocacy and collaboration to tackle global health problems to how phages can help to evolve personalized medicine to how technologies like Machine Learning and Artificial Intelligence can be used to advance Phage Therapy. Also, is there a need for more health solutions to connect the dots when traveling abroad? For more details visit TechLink Health @ https://www.techlink.health or connect with Dr. Strathdee @ The Center for Innovative Phage Applications and Therapeutics. This episode was hosted by Rob McBride, Co-Founder and CEO of Felix Biotechnology and Dr. Sarah Samaan. The episode is packed with valuable insights and points to several references, including a direct email for those in need and interested in Phage Therapies as an alternative treatment:
Today's special guest, Robert Lindsy Milne is not just the author. He is a part of the story told in his book The Perfect Predator. As described in the book, Robert and Dr. Steffanie Strathdee have known each other since 1992. He was/is still the psychic consultant and spiritual rock for her during her husband Tom's illness. In fact while he was in a coma, Robert was the one that guided the doctors to Tom's cure. Robert Lindsy Milne is here to tell us his remarkable true stories including: how he broke up a Spy Ring, how he called the "Havana turn-around", and what happened when he was contacted to interview Spy and KGB Agent, Ivan Moronoff. Robert Lindsy Milne is a Psychic-Intuitive counselor, teacher, healer, and life coach. He is recognized across the continent as one of the most insightful psychic-intuitive channelers of his time. At a very young age he realized his psychic gifts and started his first job working as a psychic intuitive doing readings at the "Cozy Tea Room" in Toronto. Robert has traveled the world giving insight with his sessions to tens of thousands of people and has become recognized across the continent. Robert has also worked with the police and Canadian Secret Service helping to gather intel and work on missing person's cases. Currently Robert is hosting his podcast, My Side of the Crystal Ball.
Infectious Conversations: Getting a Grip on How to #SquashSuperbugs
In the newest episode of Infectious Conversations, Candace chats with Dr. Steffanie Strathdee: an infectious disease epidemiologist, the Associate Dean of Global Health Sciences at the University of California San Diego School of Medicine, and Co-director at the Center for Innovative Phage Applications and Therapeutics (IPATH). Dr. Strathdee relied on her extensive knowledge of infectious diseases to help save her husband's life using phage therapy after he developed a life-threatening, drug-resistant infection in 2016. The couple later wrote a book together titled “The Perfect Predator: A Scientist's Race to Save Her Husband from a Deadly Superbug,” which was published in 2019. To contact IPATH, email ipath@ucsd.edu.
Epidemiologist Steffanie Strathdee and her husband, psychologist Tom Patterson, were vacationing in Egypt when Tom came down with a stomach bug. What at first seemed like a case of food poisoning quickly turned critical, and by the time Tom had been transferred via emergency medevac to the world-class medical center at UC San Diego, where both he and Steffanie worked, blood work revealed why modern medicine was failing: Tom was fighting one of the most dangerous, antibiotic-resistant bacteria in the world.Steffanie joins Greg this episode to discuss solving her husband's medical crisis, and what she learned from this horrific experience. They also discuss how Covid has ramped these trends up, how critical phages are for our bodies, and the open mindedness of PhDs vs MDs.Steffanie is Associate Dean of Global Health Sciences and Harold Simon Distinguished Professor in the Department of Medicine at the University of California San Diego School of Medicine. She is also an Adjunct Professor at Johns Hopkins and Simon Fraser Universities. She co-directs UCSD's new center for Innovative Phage Applications and Therapeutics (IPATH), Global Health Institute and the International Core of UCSD's Center for AIDS Research. Stefanie has co-authored her memoir all about her husbands illness titled, “The Perfect Predator: A Scientist's Race to Save Her Husband from a Deadly Superbug.”Episode Quotes:The need for a phage library[30:40] What we need to do is build a phage library that maps onto a superbug library. And, of course, these are going to be constantly needing to be updated because these are organisms that are co-evolving to attack one another.What's the future looking for the advancement of phage[37:55] I can imagine a situation in the future, though, where, because we have, sequencers that are portable and cheaper than ever before, that you'd be able to sequence a phage and sequence a bacteria and be able to have a database to say, okay, you know, this phage will match that bacterium or to even genetically modify or synthesize a phage. So in a 3D printing model, some of my colleagues in Belgium have, you know, been working on that. So, I think that there's going to be advances that are going to help us make this work. But right now, we need phage libraries. We need more investment in clinical trials.Pushing beyond boundaries leads to discovery[39:49] When your back is up against the wall, whether it's you as an individual, us as a society, or a planet, we can sometimes have creative ideas to come up with solutions that we wouldn't otherwise do. And that's what I'm hoping that we'll do now because both climate change and antimicrobial resistance are colliding.Show Links:Guest Profile:Faculty Profile at UC San DiegoFaculty Profile at John Hopkins Bloomberg School of Public HealthProfessional Profile at Canadian Association for Global HealthSteffanie Strathdee on LinkedInSteffanie Strathdee on TwitterSteffanie Strathdee on InstagramSteffanie Strathdee on TEDxNashvilleHer Work:Steffanie Strathdee on Google ScholarThe Perfect Predator Website
A bracing medical thriller about one woman's race to save her husband from a lethal, antibiotic-resistant superbug. Epidemiologist Steffanie Strathdee and her husband, psychologist Tom Patterson, were vacationing in Egypt when Tom came down with a stomach bug. Steffanie dosed Tom with an antibiotic and expected the discomfort to pass. Instead, his condition turned critical. Local doctors at an Egyptian clinic, an emergency medevac team and then a German hospital failed to cure him. By the time Tom reached the world-class medical center at UC San Diego, where both he and Steffanie worked, bloodwork revealed why modern medicine was failing: Tom was fighting one of the most dangerous, antibiotic-resistant bacteria in the world. Frantic, Steffanie combed through research old and new and came across phage theory: the idea that the right virus, aka “the perfect predator,” can kill even the most lethal bacteria. Phage treatment had fallen out of favor almost 100 years ago, after antibiotic use went mainstream. Now, with time running out, Steffanie appealed to phage researchers all over the world for help. . . and together they achieved a major medical breakthrough. The Perfect Predator is a nail-biting account of how Steffanie resurrected a forgotten cure—allying with the FDA, researchers from Texas A&M, and a clandestine Navy biomedical center—to design a treatment and save her husband before it was too late. The Perfect Predator is a story of love and against-all-odds survival, detailing how Steffanie helped uncover the science behind a powerful new weapon in the global superbug crisis.
In today's show, we sit down with Dr. Steffanie Strathdee, whose family story of saving her husband's life from a life-threatening superbug infection using phage therapy really inspired a lot of the most important works today in the phage therapy field. Listen to today's episode to learn about her story. Among her many roles, as the director of the 'Center for Innovative Phage Applications and Therapeutics' at UC San Diego, Dr. Strathdee also get to help us understand the scope of power we have today in our field and much more... Dr. Strathdee and her husband shared their story in their memoir "The Perfect Predator: A Scientists's Race to Save Her Husband from a Deadly Superbug", which can be found @ https://www.amazon.com/dp/B07H282CPT?ref=KC_GS_GB_US Their story has also recently been spread nationwide through CNN @https://www.cnn.com/2022/07/08/health/phage-superbug-killer-life-itself-wellness/index.html Find out more about UCSD IPATH and their resource @https://medschool.ucsd.edu/som/medicine/divisions/idgph/research/center-innovative-phage-applications-and-therapeutics/people/Pages/default.aspx Happy listening!
Dr. Steffanie Strathdee is Associate Dean of Global Health Sciences and Harold Simon Distinguished Professor in the Department of Medicine at the University of California San Diego School of Medicine. She co-directs UCSD's new center for Innovative Phage Applications and Therapeutics (IPATH), Global Health Institute and the International Core of UCSD's Center for AIDS Research. An infectious disease epidemiologist, she has spent the last two decades focusing on HIV prevention in marginalized populations and has published over 600 peer-reviewed publications. She has recently begun working to move bacteriophage therapy into clinical trials at IPATH. She has co-authored her memoir, The Perfect Predator: A Scientist's Race to Save Her Husband from a Deadly Superbug. In this podcast we talk about Dr. Strathdee's experiences learning about bacteriophage (phage) therapy treatment through a personal experience where her husband became extremely ill from antimicrobial resistant bacteria. She learned that stigma in part was how phage therapy had become forgotten in North America--stigma toward scientists with different beliefs and training than the mainstream, stigma toward viruses that maybe perceived "at the borderline of life", and stigma toward research based on geopolitics (including the "Russian taint"). Steffanie inspires listeners with her discussion of the power of global collaboration, advocacy in healthcare, and the importance of making (rather than waiting for) miracles to happen. Episode hosted by Dr. Carmen Logie. Supported by funding from the Canada Foundation for Innovation and Canada Research Chairs program. Original music and podcast produced by Jupiter Productions, who have various production services available to support your podcast needs.
It started with a tweet. A 25 year old woman named Mallory was suffering from an infection that had failed all antibiotic treatments. A researcher named Dr. Steffanie Strathdee was using Twitter to hunt for the impossible - a scientist somewhere in the world who might have the right phage - a virus that infects bacteria - that could save this patient. When Jessica Sacher (a phage researcher) showed her friend Jan Zheng (a UI/UX developer) the tweet, the idea for Phage Directory was born. A simple, elegant solution to a global problem. Phage Directory started as a list of phage researchers and a newsletter called Capsid & Tail. To date, it has facilitated multiple phage cures, grown a global community of researchers who hold potential treatments for future drug-resistant infections, and built a model for discovery research from benchtop to bedside, N-of-1 cures. Jan and Jessica are making the leap to Australia to further their mission with Phage Directory and help build a safety net on a country-wide scale for these types of infections. Get inspired by the progress that Jan, Jessica, and their research community has made for cures of drug-resistant infections through a global, decentralized network of researchers.This is an UltraRare x VitaDAO collaborative podcast. Thank you for listening.Website: https://phage.directory/Guest Twitter:https://twitter.com/JessicaSacherhttps://twitter.com/yawnxyzJessica Sacher BLOGhttps://jessbio.substack.com/Hosted by Jocelynn Pearlhttps://twitter.com/JocelynnPearlVitaDAO is the world's first decentralized intellectual property collective, funding and commissioning research into human longevity. Participate in the VitaDAO community! ⇛ Website : https://www.vitadao.com/⇛ Discord: https://discord.gg/vitadao⇛ Telegram: https://t.me/vitadao⇛ Twitter: https://twitter.com/vita_daoTimestamps00:00 Intro.1:07 Intro of Phage Directory co-founders2:13 How the idea of Phage Directory came about? (Jessica Sacher)4:57 Background and experience in tech (Jan Zheng)8:40 The first successes with Phage Directory12:04 How does the alert to cure process look like?16:20 The bottlenecks in the process18:58 The process of putting together Phage Directory23:41 Community onboarding29:40 How is Phage Directory monetized?33:28 The business model of Phage Directory35:13 Why is Australia a good place for phage Directory?40:28 Phage Directory strategy43:15 Ways to access the information about the Phage Directory process44:50 The relationship between the co-founders46:17 Web 3 space and Phage Directory53:00 The options of becoming a DAO54:14 The vision for Phage Directory for the next 5 to 10 years1:03:00 Ways to support the mission1:04:56 How big is the network?1:07:00 How to get involved and be part of the community?1:11:25 Closing
Antimicrobial Resistance - or AMR - is a term most people have likely heard, but few actually know the extent of the deadly threat it poses. Recent reports show that AMR now results in an estimated 700,000 deaths annually, worldwide and is predicted to increase to over 10 million annually by 2050 – surpassing predictions of annual deaths for cancer (8.2 million) and diabetes (1.5 million). Data also shows that the COVID-19 pandemic may have accelerated the threat of AMR, due to the many hospital admissions of patients with COVID-19 symptoms who are then treated with antibiotics to reduce chances of contracting secondary bacterial infections, increasing the commonality of resistant bacteria. Tune in as Jan Poolman, Head Bacterial Vaccine Discovery and Early Development at Janssen Infectious Diseases and Dr. Steffanie Strathdee, Distinguished Professor, UC San Diego Department of Medicine, Co-Director, Center for Innovative Phage Applications and Therapeutics and author of The Perfect Predator discuss the potential threats that AMR can pose, and what a potential global action plan to protect against AMR would look like.
In this week’s episode of Farmer’s Inside Track…7 steps to get your own land in South Africa. Finding and purchasing land to farm seems daunting but their are a few simple steps to take to find land to filful your farming dream! Agricultural economist Thabi Nkosi questions why the agriculture sector is often seen as the perpetual ugly duckling? She presents a somewhat disarming take on the state of agriculture in Africa. Farmers choose The Perfect Predator by Steffanie Strathdee and Thomas Patterson as their book of the week. This book provides a glimpse into the potential treatment of bacterial infections in an antibiotic resistant world through the use of bacteriophages, bacteria-eating viruses. In the South African National Budget Review for 2021, it was revealed that government’s recovery plan focuses on raising the economy’s long-term growth rate by supporting industries with high employment potential such as agriculture. Unathi Mhlatyana, MD at McCain Foods says it’s because the agricultural supply chain holds many job opportunities and along with this, the sector has seen a positive growth trajectory since 2019. And organic fertilizer specialists, Thapelo Phiri encourages farmers to explore organic fertilizers to farm more sustainably…
"This is the worse superbug you can get," said her husband's doctors when diagnosing him with a life-threatening multidrug resistant bacterial infection. But Steffanie Strathdee put her research skills to work and eventually was able to convince doctors to treat him with an experimental phage therapy that ended up saving his life. Listen and learn Why no other solution was working to cure her husband of this superbug, How the history of phage therapy versus antibiotics has played out, and Why the problem of antibiotic resistance may be addressed by utilizing bacteriophages. Steffanie A. Strathdee is the Associate Dean of Global Health Sciences and the Harold Simon Professor in the Department of Medicine at the University of California San Diego School of Medicine. She helped found and co-directs UCSD's new center for Innovative Phage Applications and Therapeutics (IPATH) and also works with the Global Health Institute and the International Core of UCSD's Center for AIDS Research. An infectious disease epidemiologist, she's also the author of The Perfect Predator, which tells the story of her husband's struggle with a superbug and the successful effort to help him recover with phage viruses. Phages are viruses that infect bacteria, and are emerging as a potential winner as scientists struggle with how to prevent superbugs from causing deadly infections. She gives listeners a fascinating history of how politics and war kept phage therapy out of American medicine for decades. First discovered by a French Canadian microbiologist, their adoption by Russians pre-World War II marked them as off-the-table for the American medical field. But they are emerging again as having great potential, and Steffanie Strathdee helps enlighten listeners by describing the process and why they can be effective. First, scientists are able to pick and choose their phages, testing to make sure what bacteria the phages will infect. They can get specific, killing only the bacteria they want to target. Ideally, they'll collect a couple of different phages for the best chances of success, then make isolates of them. The most difficult stage is the purification, she says. Scientists are moving ahead, designing clinical studies. Listen in for more exciting news about this life-saving treatment. For more, see the Innovative Phage Applications and Therapeutics (IPATH) website. Available on Apple Podcasts: apple.co/2Os0myK
In 2016, Dr. Steffanie Strathdee was involved in a remarkable case where she and her colleagues revived a hundred year old forgotten cure - bacteriophage therapy - to save her husband’s life from a deadly superbug infection. Strathdee shares the details of her family’s story and discusses ethical issues related to treating bacterial infections with viruses. Series: "Exploring Ethics" [Health and Medicine] [Humanities] [Show ID: 36633]
In 2016, Dr. Steffanie Strathdee was involved in a remarkable case where she and her colleagues revived a hundred year old forgotten cure - bacteriophage therapy - to save her husband’s life from a deadly superbug infection. Strathdee shares the details of her family’s story and discusses ethical issues related to treating bacterial infections with viruses. Series: "Exploring Ethics" [Health and Medicine] [Humanities] [Show ID: 36633]
In 2016, Dr. Steffanie Strathdee was involved in a remarkable case where she and her colleagues revived a hundred year old forgotten cure - bacteriophage therapy - to save her husband’s life from a deadly superbug infection. Strathdee shares the details of her family’s story and discusses ethical issues related to treating bacterial infections with viruses. Series: "Exploring Ethics" [Health and Medicine] [Humanities] [Show ID: 36633]
In 2016, Dr. Steffanie Strathdee was involved in a remarkable case where she and her colleagues revived a hundred year old forgotten cure - bacteriophage therapy - to save her husband’s life from a deadly superbug infection. Strathdee shares the details of her family’s story and discusses ethical issues related to treating bacterial infections with viruses. Series: "Exploring Ethics" [Health and Medicine] [Humanities] [Show ID: 36633]
In 2016, Dr. Steffanie Strathdee was involved in a remarkable case where she and her colleagues revived a hundred year old forgotten cure - bacteriophage therapy - to save her husband’s life from a deadly superbug infection. Strathdee shares the details of her family’s story and discusses ethical issues related to treating bacterial infections with viruses. Series: "Exploring Ethics" [Health and Medicine] [Humanities] [Show ID: 36633]
In 2016, Dr. Steffanie Strathdee was involved in a remarkable case where she and her colleagues revived a hundred year old forgotten cure - bacteriophage therapy - to save her husband’s life from a deadly superbug infection. Strathdee shares the details of her family’s story and discusses ethical issues related to treating bacterial infections with viruses. Series: "Exploring Ethics" [Health and Medicine] [Humanities] [Show ID: 36633]
In 2016, Dr. Steffanie Strathdee was involved in a remarkable case where she and her colleagues revived a hundred year old forgotten cure - bacteriophage therapy - to save her husband’s life from a deadly superbug infection. Strathdee shares the details of her family’s story and discusses ethical issues related to treating bacterial infections with viruses. Series: "Exploring Ethics" [Health and Medicine] [Humanities] [Show ID: 36633]
In 2016, Dr. Steffanie Strathdee was involved in a remarkable case where she and her colleagues revived a hundred year old forgotten cure - bacteriophage therapy—to save her husband’s life from a deadly superbug infection. Strathdee shares the details of her family’s story and discusses ethical issues related to treating bacterial infections with viruses. Series: "Exploring Ethics" [Health and Medicine] [Humanities] [Show ID: 36633]
In 2015, Steffanie Strathdee's husband nearly died from a superbug, an antibiotic resistant bacteria he contracted in Egypt. Desperate to save him, she reached out to the scientific community for help. What she got back? A 100-year-old treatment that's considered experimental in the U.S. Strathdee, an infectious disease epidemiologist, tells us how it works, its drawbacks, and its potential role in our fight against superbugs. (Encore episode.)
In Superbug Slayer we are joined by Associate Dean of Global Health Sciences and Harold Simon Professor in the Department of Medicine at the University of California San Diego School of Medicine, Dr. Steffanie Strathdee, to chat about superbugs and how to treat them. In this episode Steffanie shares with us the incredible story of how she helped resurrect a little known, but highly effective, treatment for antibiotic resistance bacteria and, in the process, saved her husband’s life. What is phage therapy and how can it reduce our reliance on antibiotics? Which infections can be treated with phage therapy? What can you do to prevent superbugs becoming the next global health crisis? All this and much more in Superbug Slayer with Dr. Steffanie Strathdee!
These tiny, ancient predators do more than cause pandemics. Host Kenneth Cukier and science editor Geoff Carr investigate how viruses have shaped the world. Evolutionary biologist David Enard explains how viruses have driven human development. And Jennifer Doudna, who pioneered CRISPR gene editing, and Steffanie Strathdee, an innovator in phage therapy, show how cells’ antiviral defences as well as viruses themselves can be harnessed to protect the future of humanity. Please subscribe to The Economist for full access to print, digital and audio editions:www.economist.com/podcastoffer See acast.com/privacy for privacy and opt-out information.
These tiny, ancient predators do more than cause pandemics. Host Kenneth Cukier and science editor Geoff Carr investigate how viruses have shaped the world. Evolutionary biologist David Enard explains how viruses have driven human development. And Jennifer Doudna, who pioneered CRISPR gene editing, and Steffanie Strathdee, an innovator in phage therapy, show how cells’ antiviral defences as well as viruses themselves can be harnessed to protect the future of humanity. Please subscribe to The Economist for full access to print, digital and audio editions:www.economist.com/podcastoffer See acast.com/privacy for privacy and opt-out information.
Antimicrobial resistant infections are a major threat to global public health. In this month's episode, we explore using bacteriophages to combat these deadly infections. Niki Spahich from The Scientist's Creative Services team spoke with Jason Gill, associate director of the Center for Phage Technology at Texas A&M University, and Steffanie Strathdee, associate dean of Global Health Sciences at the University of California, San Diego, to learn more. The Scientist Speaks is a podcast produced by The Scientist's Creative Services Team. Our podcast is by scientists and for scientists. Once a month, we bring you the stories behind news-worthy molecular biology research. Special thanks to Dr. Steffanie Strathdee and Dr. Jason Gill for sharing their experiences. Steffanie Strathdee and Thomas Patterson's book about his illness is "The Perfect Predator: A Scientist's Race to Save Her Husband from a Deadly Superbug: A Memoir." More information can be found at ThePerfectPredator.com. If you enjoyed this episode, please subscribe to The Scientist Speaks on your favorite podcast platform.
While on a bucket list trip to Egypt, Steffanie Strathdee's husband Tom Patterson fell ill with what they first assumed to be food poisoning. They soon discovered it was much more serious. Tom was diagnosed with pancreatitis and gallstones. The gallstones had blocked his biliary duct, which had caused an abscess the size of a small football to form in his abdomen. When the fluid inside the abscess was cultured, doctors found the “worst bacteria on the planet,” Acinetobacter baumannii. This bacteria, nicknamed Iraqibacter due to the veterans who have returned from the middle east with the superbug, is an organism that is very prone to acquiring antimicrobial resistance genes from other bacteria. Tom was very ill. With the combination of pancreatitis and the superbug, his chance of survival was no more than 10%. Acinetobacter baumannii was only partially sensitive to three known antibiotics, and those were considered to be last chance therapies. He was treated with those drugs, but his bacteria resisted all of them. Steffanie is an infectious disease epidemiologist, but felt blindsided by Tom's diagnosis. Luckily, she had the right combination of knowledge, access to research, and willing medical and research professionals to try alternative therapies. Her research led her to phage therapy. Bacteriophage therapy (phage therapy, for short), are viruses that have naturally evolved to attack bacteria. The perfect predator, they have been co-evolving with bacteria for 4 billion years. There are more than 10 million trillion trillion phages on earth and they are everywhere: in water, soil, and our bodies. Phage therapy has been a known treatment against bacteria for decades, but has been practiced more in the former Soviet Union since western countries started relying on penicillin and other antibiotics since the 1940's. The challenge is to find the particular phage that is effective against the bacterial infection being treated. You are going to love this story of love, determination, resourcefulness and triumph. Steffanie cured Tom's illness with the help of three universities, the US Navy and researchers from across the world. What she discovered in the process is a super weapon against multidrug antimicrobial resistant diseases, which are expected to kill more than ten million people per year by 2050. Links and notes: Steffanie Strathdee and Robert Schooley are co-directors of the Center for Innovative Phage Applications and Therapeutics (“IPATH”) at UC San Diego Donate to IPATH here Steffanie Strathdee and Tom Patterson's book about their ordeal is called The Perfect Predator Learn more about The Infection Prevention Strategy at ic.tips If you liked this podcast, please consider subscribing to the series and leaving a positive review
As an Epidemiologist, Dr. Steffanie Strathdee studies the world's deadliest diseases. From the Wuhan Coronavirus and HIV, to Measles and Supebugs, we talk the microscopic dangers that could impact us all. Plus, the forgotten treatment that saved her husband's life. Then John Shull eavesdrops on people's conversations. And we countdown the Top 5 Breakfast Foods. Dr. Strathdee: 01:22 John Shull: 30:38 Top Breakfast Foods: 44:44 Contact the Show Instagram Twitter Facebook Dr. Strathdee's Twitter Center for Innovative Phage Applications and Therapeutics The Perfect Predator book Dr. Strathdee's TEDx talk
In 2015, Steffanie Strathdee's husband nearly died from a superbug, an antibiotic resistant bacteria he contracted in Egypt. Desperate to save him, she reached out to the scientific community for help. What she got back? A 100-year-old treatment that's considered experimental in the U.S. Strathdee, an infectious disease epidemiologist, tells us how it works, its limitations, and its potential role in our fight against superbugs. Follow host Maddie Sofia on Twitter @maddie_sofia. Email the show at shortwave@npr.org.
On this episode, we are taking a closer look at the extremely real, human threat of antibiotic resistant infections, and discussing how momentum for beating these harmful bugs can start from just one person with a determination to find a solution. Co-host Matthew Wellington from U.S. PIRG interviewed Dr. Steffanie Strathdee, co-author of the book The Perfect Predator - A Scientist’s Race to Save Her Husband from a Deadly Superbug. Dr. Strathdee is the Associate Dean of Global Health Sciences, Harold Simon Professor at the University of California San Diego School (UCSD) of Medicine and Co-Director at the Center for Innovative Phage Applications and Therapeutics. In this episode, she tells the story of how her husband, Tom Patterson, was infected with a bacteria that was resistant to all available antibiotics and how doctors and researchers from around the world saved his life with a hundred year old forgotten cure—phage therapy—that shows promise as a weapon to tackle the global superbug crisis. Her husband co-authored the book with her and is also a renowned scientist at UCSD. To wrap up, Matt will dive into the news and updates currently chiming across the world of antibiotic resistance.
Ira Pastor, ideaXme exponential health ambassador, interviews Dr. Jack T. Stapleton, MD, Professor of Internal Medicine - Infectious Diseases, Professor of Microbiology and Immunology, University of Iowa College of Medicine, and Director of the Levitt Center for Viral Pathogenesis. Ira Pastor Comments: On today’s show we are going to jump back into the theme of viruses and the human virome. Viruses are infective agents that typically consist of a nucleic acid molecule in a protein coat, and which is able to multiply only within the living cells of a host. The virome defines the collection of all viruses that make up a specific viral community. On a few recent shows we’ve touched on some interesting topics in relation to both the beneficial therapeutic applications of certain viruses (thinking about our discussions surrounding bacteriophage therapies with Dr. Steffanie Strathdee at UC San Diego) as well as some of the pathological states where viruses may play a much more prominent role in disease progression than previously thought (per our discussions with Prof. Ruth Itzhaki from University of Manchester and her study of the viral connections in Alzheimer's Disease). Viral Co-Infection Today we are going to delve into the fascinating topic of "viral co-infection." Co-infection is defined the simultaneous infection of a host by multiple pathogen species. In virology, co-infection includes simultaneous infection of a single cell by two or more virus particles. An example is the co-infection of liver cells with Hepatitis B virus and Hepatitis D virus, which can arise incrementally by initial infection followed by super-infection. Co-infection is of particular human health importance because pathogen species can interact within the host. The net effect of co-infection on human health is thought to be usually negative (known as "syndemism", which is synergistic event that can cause super-infections), but interactions can also have very positive effects when one species suppresses the virulence or colonisation of another. Dr. Jack Stapleton Today we are joined by Dr. Jack T. Stapleton, MD, Professor of Internal Medicine - Infectious Diseases, Professor of Microbiology and Immunology, University of Iowa College of Medicine, and Director of the Levitt Center for Viral Pathogenesis Dr. Stapleton's research interests focus on the molecular biology, epidemiology and effects of co-infection of Hepatitis C virus, Human GB virus type C (GBV-C; also called Hepatitis G virus), and the Human Immunodeficiency Virus (HIV). In addition, he has clinical studies under way related to antiviral therapy and the management and therapy of HIV, Hepatitis C virus, and GBV-C. On this episode we will here from Dr. Stapleton: About his background, how he developed an interest in medicine, infectious disease, and how he moved into the very interesting area of viral co-infection dynamics. His views on the "Beneficial Virome." His discovery of the unique and beneficial properties of GBV-C co-infection. Therapeutic opportunities related to viral co-infection dynamics. Finally, about the current state of treatments, cures, and vaccines as it pertains to HIV / AIDS. Credits: Ira Pastor interview video, text, and audio. Follow Ira Pastor on Twitter:@IraSamuelPastor If you liked this interview, be sure to check out ourinterview with Professor Ruth Itzhaki exploring the viral causes of Alzheimer's! Follow ideaXme on Twitter:@ideaxm On Instagram:@ideaxme Find ideaXme across the internet including oniTunes,SoundCloud,Radio Public,TuneIn Radio,I Heart Radio, Google Podcasts, Spotify and more. ideaXme is a global podcast, creator series and mentor programme. Our mission: Move the human story forward!™ ideaXme Ltd.
We can't say we weren't warned. More than 75 years ago, bacteriologist Rene Dubos cautioned that misuse of antibiotics could breed drug-resistant bacteria – and he has been proved prescient. In this episode: the rise of superbugs, why we ignored the warnings about them, how some are enlisting an old therapy to fight back, and whether we'll heed history's lessons in the face of a future pandemic. Plus, a weird unforeseen effect of antibiotics being investigated at the Body Farm. Guests: Fred Turek - Director of the Center for Sleep and Circadian Biology, Department of Neurobology, Northwestern University Jennifer DeBruyn - Microbiologist at the University of Tennessee, who also works at the Anthropology Research Facility, a.k.a. the Body Farm Steffanie Strathdee - Associate Dean of Global Health Sciences at the University of California, San Diego, and co-author (with Tom Patterson) of “The Perfect Predator: A Scientist's Race to Save Her Husband from a Deadly Superbug” Tom Patterson - Professor of Psychiatry at the University of California, San Diego, and co-author (with Steffanie Strathdee) of “The Perfect Predator: A Scientist's Race to Save Her Husband from a Deadly Superbug” Mark Honigsbaum - Medical Historian, journalist, and lecturer at City University, London, and author of “The Pandemic Century: One Hundred Years of Panic, Hysteria, and Hubris” Learn more about your ad choices. Visit megaphone.fm/adchoices
We can’t say we weren’t warned. More than 75 years ago, bacteriologist Rene Dubos cautioned that misuse of antibiotics could breed drug-resistant bacteria – and he has been proved prescient. In this episode: the rise of superbugs, why we ignored the warnings about them, how some are enlisting an old therapy to fight back, and whether we’ll heed history’s lessons in the face of a future pandemic. Plus, a weird unforeseen effect of antibiotics being investigated at the Body Farm. Guests: Fred Turek - Director of the Center for Sleep and Circadian Biology, Department of Neurobology, Northwestern University Jennifer DeBruyn - Microbiologist at the University of Tennessee, who also works at the Anthropology Research Facility, a.k.a. the Body Farm Steffanie Strathdee - Associate Dean of Global Health Sciences at the University of California, San Diego, and co-author (with Tom Patterson) of “The Perfect Predator: A Scientist’s Race to Save Her Husband from a Deadly Superbug” Tom Patterson - Professor of Psychiatry at the University of California, San Diego, and co-author (with Steffanie Strathdee) of “The Perfect Predator: A Scientist’s Race to Save Her Husband from a Deadly Superbug” Mark Honigsbaum - Medical Historian, journalist, and lecturer at City University, London, and author of “The Pandemic Century: One Hundred Years of Panic, Hysteria, and Hubris”
Absolute honour to have Dr. Steffanie Strathdee as my guest for episode 19. Dr. Strathdee is an infectious disease epidemiologist, Associate Dean of Global Health Sciences, Harold Simon Professor at the University of California San Diego School of Medicine and Co-Director at the Center for Innovative Phage Applications and Therapeutics. Herself and husband; Thomas Patterson, are also authors of the book 'The Perfect Predator: A Scientist's Race to Save Her Husband from a Deadly Superbug'.On the podcast we talk about Phage Therapy, what it is and the difference it can make in the Superbug Epidemic, the struggle Dr. Strathdee and her husband faced, recovery and everything that happened in between. I really hope you find it as fascinating and important as I did. Follow Dr. Strathdee on:Twitter - https://twitter.com/chngin_the_wrldInstagram - https://www.instagram.com/chngin_the_wrldCheck out Dr. Strathdee's University Profile here: https://profiles.ucsd.edu/steffanie.strathdeeFor more information on 'The Perfect Predator' head here: https://theperfectpredator.comPurchase the book: https://amzn.to/2Q50tnPFind out more about IPATH (Center for Innovative Phage Applications and Therapeutics):Website: https://bit.ly/2kGpg2HFacebook: https://www.facebook.com/IPATH/Twitter: https://twitter.com/IPATHContact IPATH: IPATH@ucsd.eduMake sure to give us a follow and give this episode a share, it helps the world and this is a topic which completely deserves it! Support the show (https://ko-fi.com/miztrujillo)
When Tom Patterson caught a superbug infection in 2015, he thought his life was over. The antibiotics had stopped working, he was in a coma and doctors had given up hope. But his wife - scientist Steffanie Strathdee - went on an international medical quest to save him. Tom and Steffanie have written a book about their experience - 'The Perfect Predator: A scientist's race to save her husband from a deadly superbug'. Presenter: Jonny Dymond Producer: Asya Fouks Picture: Tom Patterson and Steffanie Strathdee holding pictures of bacteria and phages Credit: USCD Health
ELT answers an age-old question: When you have to use a public toilet, should you sit on the seat? A team of microbiologists weigh in. Plus, the rise, fall, and re-rise of cargo shorts. Guests: Microbiologist Jack Gilbert; comedian Prashanth Venkataramanujam; cargo pantsologist Joe Hancock; Wall Street Journal reporter Nicole Hong. Special thanks to caller Jenny and the biology experts we surveyed: Jason Tetro, William Schaffner, Chuck Gerba, Rob Dunn, Jenny Hayden, Steffanie Strathdee, Liz Scott, Kimberly Page, and Maria Gloria Dominguez-Bello.
Sometimes the personal is professional. It’s not all that common when ones work and one's survival is linked so inexorably together. They are in the story Tom Patterson and Steffanie Strathdee. Imagine, you're climbing a mountain, you slip and your spouse is the clinging to the rope above you and that’s the only thing keeping you alive. In the story of Tom and Steffanie, it was Steffanie clinging to science, history and medical bravery that Tom would have to hang on to. They tell their remarkable story in The Perfect Predator: A Scientist's Race to Save Her Husband from a Deadly Superbug: A Memoir My conversation with Tom Patterson & Steffanie Strathdee:
A Canadian infectious disease epidemiologist, Steffanie Strathdee turned to a very old, and experimental treatment option after her husband, Thomas Patterson, contracted a superbug while they were travelling in Egypt in 2015. She looked into something called “Phage Therapy” (using an infection to fight an infection).
Steffanie A. Strathdee is the associate dean of global health science at the University of California San Diego School of Medicine and Co-Director at the Center for Innovative Phage Applications and Therapeutics. She is known for her work on HIV research and prevention programmes in Tijuana.
In 2015, Steffanie Strathdee and her husband Tom Patterson were travelling in Egypt when he fell ill from a powerful strain of bacteria. Pattersons prospects were not good…but Strathdee, a doctor specializing in the study of disease, came across a radical fix. Phage therapy (as it’s called) was pioneered in the early 20th century by a Canadian doctor to fight bacteria. It fell out of use as antibiotics became the norm. In their new book, “the perfect predator’, Strathdee describes the process of using this natural viral attacker to save her husband’s life.
Tens of thousands of people die every year because bacterial infections are becoming resistant to antibiotics. That number is expected to explode, as more antibiotics stop working, making antimicrobial resistance, or AMR, one of the gravest health threats facing humanity. But could viruses come to the rescue? Bacteriophages, or phages for short, are viruses that infect and kill bacteria. They were discovered 100 years ago and have been used to treat infections for decades in Georgia. But despite their abundance in nature and proven ability to kill infections, their potential has not yet been realised outside the former Soviet Union and Eastern Europe. Steffanie Strathdee, who stumbled across phages as she tried to save her husband’s life, is now leading a campaign to put phages on the map. But can their use be scaled up from individual and costly treatments to a fully-operational weapon in the war against AMR? Reporter: Tom Colls (Photo Caption: A phage under an electron microscope / Photo Credit: University of Leicester)
Finland is pretty happy right now. Not for any specific reason. They just are. Steffanie is also pretty happy, mostly because her husband is alive. Did you know that there are helpful viruses that eat bacteria? She certainly does. The Perfect Predator: A Scientist's Race to Save Her Husband from a Deadly Superbug: A MemoirBook Link-bit.ly/PerfectPredatorSee omnystudio.com/listener for privacy information.See omnystudio.com/listener for privacy information.
Delve into the realms of predatory superbugs with infectious disease epidemiologist Steffanie Strathdee and her husband, psychologist Thomas Patterson. This is an incredible story of Strathdee's fight to save her husband's life, which led her to rediscover a forgotten treatment for antibiotic-resistant bacteria. This unprecedented treatment saved Patterson's life as well as several others and helped launch the Center for Innovative Phage Applications and Therapeutics (IPATH) at UC San Diego, the first phage therapy center in North America. Series: "Women in Science" [Health and Medicine] [Humanities] [Show ID: 34410]
Delve into the realms of predatory superbugs with infectious disease epidemiologist Steffanie Strathdee and her husband, psychologist Thomas Patterson. This is an incredible story of Strathdee’s fight to save her husband’s life, which led her to rediscover a forgotten treatment for antibiotic-resistant bacteria. This unprecedented treatment saved Patterson’s life as well as several others and helped launch the Center for Innovative Phage Applications and Therapeutics (IPATH) at UC San Diego, the first phage therapy center in North America. Series: "Women in Science" [Health and Medicine] [Show ID: 34410]
Delve into the realms of predatory superbugs with infectious disease epidemiologist Steffanie Strathdee and her husband, psychologist Thomas Patterson. This is an incredible story of Strathdee’s fight to save her husband’s life, which led her to rediscover a forgotten treatment for antibiotic-resistant bacteria. This unprecedented treatment saved Patterson’s life as well as several others and helped launch the Center for Innovative Phage Applications and Therapeutics (IPATH) at UC San Diego, the first phage therapy center in North America. Series: "Women in Science" [Health and Medicine] [Show ID: 34410]
Delve into the realms of predatory superbugs with infectious disease epidemiologist Steffanie Strathdee and her husband, psychologist Thomas Patterson. This is an incredible story of Strathdee’s fight to save her husband’s life, which led her to rediscover a forgotten treatment for antibiotic-resistant bacteria. This unprecedented treatment saved Patterson’s life as well as several others and helped launch the Center for Innovative Phage Applications and Therapeutics (IPATH) at UC San Diego, the first phage therapy center in North America. Series: "Women in Science" [Health and Medicine] [Show ID: 34410]
Delve into the realms of predatory superbugs with infectious disease epidemiologist Steffanie Strathdee and her husband, psychologist Thomas Patterson. This is an incredible story of Strathdee’s fight to save her husband’s life, which led her to rediscover a forgotten treatment for antibiotic-resistant bacteria. This unprecedented treatment saved Patterson’s life as well as several others and helped launch the Center for Innovative Phage Applications and Therapeutics (IPATH) at UC San Diego, the first phage therapy center in North America. Series: "Women in Science" [Health and Medicine] [Show ID: 34410]
Delve into the realms of predatory superbugs with infectious disease epidemiologist Steffanie Strathdee and her husband, psychologist Thomas Patterson. This is an incredible story of Strathdee’s fight to save her husband’s life, which led her to rediscover a forgotten treatment for antibiotic-resistant bacteria. This unprecedented treatment saved Patterson’s life as well as several others and helped launch the Center for Innovative Phage Applications and Therapeutics (IPATH) at UC San Diego, the first phage therapy center in North America. Series: "Women in Science" [Health and Medicine] [Show ID: 34410]
Medical researcher Steffanie Strathdee needed to save the life of her husband, researcher Tom Patterson, when he contracted one of the world's worst infections. She turned to phage therapy: using a virus to kill the bacteria.
Delve into the realms of predatory superbugs with infectious disease epidemiologist Steffanie Strathdee and her husband, psychologist Thomas Patterson. This is an incredible story of Strathdee’s fight to save her husband’s life, which led her to rediscover a forgotten treatment for antibiotic-resistant bacteria. This unprecedented treatment saved Patterson’s life as well as several others and helped launch the Center for Innovative Phage Applications and Therapeutics (IPATH) at UC San Diego, the first phage therapy center in North America. Series: "Women in Science" [Health and Medicine] [Show ID: 34410]
In November 2015, infectious disease epidemiologist Steffanie Strathdee and her husband, evolutionary psychologist Tom Patterson, were spending the week of Thanksgiving exploring pyramids and pharaoh's tombs in Egypt when Patterson came down with what seemed like a nasty bout of food poisoning aboard their cruise ship.
The rise of antibiotic resistant bacteria is a human health crisis. But few people appreciate the impact of this phenomenon on their lives. This week, we’re going to take a very personal look at what happens when someone gets a resistant infection and how a treatment from a century ago is making a comeback not just for our health but also our food supply. Our first guest is Dr. Tom Patterson. He’s a researcher at the University of California San Diego and the subject of the new book, The Perfect Predator. In 2015, he went through a nine-month ordeal in which he almost died. His infection was resistant against all antibiotics. The only reason he survived was due to the use of a method used almost a century ago, viruses of bacteria, known as bacteriophages, better known as phages. Our next guest takes us through the process of using viruses to defeat antibiotic resistant bacteria. She is Dr. Steffanie Strathdee at the University of California, San Diego. She is the author of The Perfect Predator, which is an account of her journey to save Tom from the infection. While her role as an epidemiologist may have spurred her on, her efforts had a very personal twist. Tom is her husband. In our SASS Class, we examine how these viruses can be used to improve food safety. Raw and uncooked meat carries risk of bacterial infection. Our guest teacher has been working to find ways to incorporate viruses into the food production pipeline so that we can be safe. He’s Dr. Lawrence Goodridge from the University of Guelph. If you enjoy The Super Awesome Science Show, please take a minute to rate it on Apple Podcasts and be sure to tell a friend about the show. Thanks to you, we’ve been nominated for a Canadian Podcast Award as Outstanding Science and Medicine Series. Let’s keep the awesome momentum going together! Twitter: @JATetro Email: thegermguy@gmail.com Guests: Dr. Tom Patterson https://profiles.ucsd.edu/thomas.patterson Dr. Steffanie Strathdee https://profiles.ucsd.edu/steffanie.strathdee Twitter: @chngin_the_wrld Dr. Lawrence Goodridge https://news.uoguelph.ca/2019/01/improving-food-safety-goal-of-1-million-gift/ Twitter: @SafeFoodCanuck
Happy New Year! This week, as the podcast team gears up for a brand new 2019 season, we're revisiting two of our most talked-about segments from 2018. First up is the rage-inducing inside story of America's student debt machine: How the nation's flagship loan forgiveness program is failing the very people it's meant to help. Next: Viruses that could save us all. Tom Patterson, a psychologist, was dying from a seemingly unstoppable superbug infection when his wife, Steffanie Strathdee, an epidemiologist, began considering an unconventional treatment: phage therapy. We retrace Tom's incredible journey to the brink of death and back, and this fascinating field of medical science we're only just beginning to understand.
On this week's show, a love story wrapped in a medical mystery—with a Cold War twist. Tom Patterson, a psychologist, was dying from a seemingly unstoppable superbug infection. For months, world-class doctors threw everything at him but nothing worked. That's when his wife, Steffanie Strathdee, an epidemiologist, began considering an unconventional treatment: phage therapy. Science journalist Maryn McKenna joins host Jamilah King, along with Tom and Steffanie, to recount Tom's incredible journey to the brink of death and back, and this fascinating field of medical science we're only just beginning to understand. Also on the show, Mother Jones DC bureau chief David Corn follows Trump's money: what's the deal with that failed Russian hotel bid during the 2016 election?
It’s a privilege to share the story of Tom Patterson, PhD, and his wife, Steffanie Strathdee, PhD, both faculty members at UC San Diego School of Medicine. In November 2015, they were vacationing in... A podcast about science and discovery at UC San Diego Health. In each episode, we bring you the story of one project, one discovery or one scientist.
Sir Richard Branson joins UC San Diego’s Steffanie Strathdee, Patricia Gonzalez-Zuniga, MD, and author Jon Cohen for a discussion on the costs of criminalizing drug use on marginalized communities in Tijuana and elsewhere. Series: "HIV/SIDA: The Epidemic in Tijuana" [Public Affairs] [Health and Medicine] [Show ID: 30862]
Sir Richard Branson joins UC San Diego’s Steffanie Strathdee, Patricia Gonzalez-Zuniga, MD, and author Jon Cohen for a discussion on the costs of criminalizing drug use on marginalized communities in Tijuana and elsewhere. Series: "HIV/SIDA: The Epidemic in Tijuana" [Public Affairs] [Health and Medicine] [Show ID: 30862]
Sir Richard Branson joins UC San Diego’s Steffanie Strathdee, Patricia Gonzalez-Zuniga, MD, and author Jon Cohen for a discussion on the costs of criminalizing drug use on marginalized communities in Tijuana and elsewhere. Series: "HIV/SIDA: The Epidemic in Tijuana" [Public Affairs] [Health and Medicine] [Show ID: 30862]
Sir Richard Branson joins UC San Diego’s Steffanie Strathdee, Patricia Gonzalez-Zuniga, MD, and author Jon Cohen for a discussion on the costs of criminalizing drug use on marginalized communities in Tijuana and elsewhere. Series: "HIV/SIDA: The Epidemic in Tijuana" [Public Affairs] [Health and Medicine] [Show ID: 30862]
Sir Richard Branson joins UC San Diego’s Steffanie Strathdee, Patricia Gonzalez-Zuniga, MD, and author Jon Cohen for a discussion on the costs of criminalizing drug use on marginalized communities in Tijuana and elsewhere. Series: "HIV/SIDA: The Epidemic in Tijuana" [Public Affairs] [Health and Medicine] [Show ID: 30862]
Sir Richard Branson joins UC San Diego’s Steffanie Strathdee, Patricia Gonzalez-Zuniga, MD, and author Jon Cohen for a discussion on the costs of criminalizing drug use on marginalized communities in Tijuana and elsewhere. Series: "HIV/SIDA: The Epidemic in Tijuana" [Public Affairs] [Health and Medicine] [Show ID: 30862]
Sir Richard Branson joins UC San Diego’s Steffanie Strathdee, Patricia Gonzalez-Zuniga, MD, and author Jon Cohen for a discussion on the costs of criminalizing drug use on marginalized communities in Tijuana and elsewhere. Series: "HIV/SIDA: The Epidemic in Tijuana" [Public Affairs] [Health and Medicine] [Show ID: 30862]
Sir Richard Branson joins UC San Diego’s Steffanie Strathdee, Patricia Gonzalez-Zuniga, MD, and author Jon Cohen for a discussion on the costs of criminalizing drug use on marginalized communities in Tijuana and elsewhere. Series: "HIV/SIDA: The Epidemic in Tijuana" [Public Affairs] [Health and Medicine] [Show ID: 30862]
Epidemiologist Steffanie Strathdee of UC San Diego shares stories of her global health team’s intervention efforts that have helped curb the spread of HIV and tuberculosis in Tijuana and other poor regions in the world. Series: "HIV/SIDA: The Epidemic in Tijuana" [Public Affairs] [Health and Medicine] [Show ID: 30181]
Epidemiologist Steffanie Strathdee of UC San Diego shares stories of her global health team’s intervention efforts that have helped curb the spread of HIV and tuberculosis in Tijuana and other poor regions in the world. Series: "HIV/SIDA: The Epidemic in Tijuana" [Public Affairs] [Health and Medicine] [Show ID: 30181]
In the first of a four-part series, UC San Diego epidemiologist Steffanie Strathdee and psychologist Tom Patterson start the story of how their research teams have traced the spread of HIV in Tijuana. It opens at a wound clinic in El Bordo, the section of the Tijuana River Canal where migrants and others shoot heroin and, in some cases, share needles. Dr. Patricia Gonzalez-Zuniga offers first aid as she and her staff recruit participants into Strathdee’s Proyecto El Cuete, a study which focuses on HIV prevention for people who inject drugs. Also featured is the inspiring Susi Leal Ricardi, an HIV-positive outreach worker who was once addicted to heroin and had lived in El Bordo. Leal overcame her addiction, has been clean for 14 years, and with the help of antiretroviral drugs, she has fully suppressed her HIV. She is now El Cuete’s “star promotora.” The HIV/SIDA series is based on the book “Tomorrow Is a Long Time.” Series: "UCTV Prime" [Public Affairs] [Health and Medicine] [Show ID: 30005]
In the final installment of the series based on “Tomorrow Is a Long Time: Tijuana’s Unchecked HIV/AIDS Epidemic,” writer Jon Cohen explores what it would take to end the AIDS epidemic in Tijuana by 2030, as called for by UNAIDS. Dr. Davey Smith of UC San Diego argues for aggressive, frequent HIV testing in high-risk groups and shows how cutting-edge genetic science can unravel how the virus moves through communities. Cohen explains the benefits of harm reduction strategies, such as providing clean needles and methadone to thwart HIV transmission. And, in an intervention tailored specifically to this epidemic, Steffanie Strathdee and Tom Patterson’s group at UC San Diego has begun training the Tijuana Police about HIV and urging officers to see drug addiction as a sickness, not a crime. Series: "UCTV Prime" [Public Affairs] [Health and Medicine] [Show ID: 30008]
In the final installment of the series based on “Tomorrow Is a Long Time: Tijuana’s Unchecked HIV/AIDS Epidemic,” writer Jon Cohen explores what it would take to end the AIDS epidemic in Tijuana by 2030, as called for by UNAIDS. Dr. Davey Smith of UC San Diego argues for aggressive, frequent HIV testing in high-risk groups and shows how cutting-edge genetic science can unravel how the virus moves through communities. Cohen explains the benefits of harm reduction strategies, such as providing clean needles and methadone to thwart HIV transmission. And, in an intervention tailored specifically to this epidemic, Steffanie Strathdee and Tom Patterson’s group at UC San Diego has begun training the Tijuana Police about HIV and urging officers to see drug addiction as a sickness, not a crime. Series: "UCTV Prime" [Public Affairs] [Health and Medicine] [Show ID: 30008]
In the second of a four-part series based on “Tomorrow Is a Long Time: Tijuana’s Unchecked HIV/AIDS Epidemic,” Dr. Jose Luis Burgos guides medical students from UC San Diego and Universidad Autónoma de Baja California as they offer free health care at HFiT, the Health Frontiers in Tijuana clinic at Prevencasa. The segment also features an HIV telemedicine project that spares patients a long journey to CAPASITS, the government-run HIV/AIDS clinic across town, and the Tattoo Removal Clinic, a project led by UC San Diego’s Victoria Ojeda that helps people become more presentable to potential employers. Series: "UCTV Prime" [Public Affairs] [Health and Medicine] [Show ID: 30006]
In the first of a four-part series, UC San Diego epidemiologist Steffanie Strathdee and psychologist Tom Patterson start the story of how their research teams have traced the spread of HIV in Tijuana. It opens at a wound clinic in El Bordo, the section of the Tijuana River Canal where migrants and others shoot heroin and, in some cases, share needles. Dr. Patricia Gonzalez-Zuniga offers first aid as she and her staff recruit participants into Strathdee’s Proyecto El Cuete, a study which focuses on HIV prevention for people who inject drugs. Also featured is the inspiring Susi Leal Ricardi, an HIV-positive outreach worker who was once addicted to heroin and had lived in El Bordo. Leal overcame her addiction, has been clean for 14 years, and with the help of antiretroviral drugs, she has fully suppressed her HIV. She is now El Cuete’s “star promotora.” The HIV/SIDA series is based on the book “Tomorrow Is a Long Time.” Series: "UCTV Prime" [Public Affairs] [Health and Medicine] [Show ID: 30005]
In the second of a four-part series based on “Tomorrow Is a Long Time: Tijuana’s Unchecked HIV/AIDS Epidemic,” Dr. Jose Luis Burgos guides medical students from UC San Diego and Universidad Autónoma de Baja California as they offer free health care at HFiT, the Health Frontiers in Tijuana clinic at Prevencasa. The segment also features an HIV telemedicine project that spares patients a long journey to CAPASITS, the government-run HIV/AIDS clinic across town, and the Tattoo Removal Clinic, a project led by UC San Diego’s Victoria Ojeda that helps people become more presentable to potential employers. Series: "UCTV Prime" [Public Affairs] [Health and Medicine] [Show ID: 30006]
The four-part HIV/SIDA series follows UC San Diego epidemiologist Steffanie Strathdee, psychologist Tom Patterson and their binational team of doctors, researchers, medical students and outreach workers as they document the spread of HIV in Tijuana. Starting at El Bordo in the Tijuana River Canal and moving to the clinics at Prevencasa, the Las Memorias AIDS hospice and then inside the Tijuana Police Academy, this series shows their efforts to treat and prevent HIV infection among high risk groups, including people who inject drugs, sex workers, transgender women and men who have sex with men. Also featured are photographs and stories of those impacted by HIV, as portrayed by Malcolm Linton and Jon Cohen in their book, “Tomorrow Is a Long Time.” The series concludes with an assessment of what it would take to end HIV/AIDS in Tijuana. Funding for the book and series was provided by the Ford Foundation. Series: "HIV/SIDA: The Epidemic in Tijuana" [Public Affairs] [Health and Medicine] [Show ID: 30004]
The four-part HIV/SIDA series follows UC San Diego epidemiologist Steffanie Strathdee, psychologist Tom Patterson and their binational team of doctors, researchers, medical students and outreach workers as they document the spread of HIV in Tijuana. Starting at El Bordo in the Tijuana River Canal and moving to the clinics at Prevencasa, the Las Memorias AIDS hospice and then inside the Tijuana Police Academy, this series shows their efforts to treat and prevent HIV infection among high risk groups, including people who inject drugs, sex workers, transgender women and men who have sex with men. Also featured are photographs and stories of those impacted by HIV, as portrayed by Malcolm Linton and Jon Cohen in their book, “Tomorrow Is a Long Time.” The series concludes with an assessment of what it would take to end HIV/AIDS in Tijuana. Funding for the book and series was provided by the Ford Foundation. Series: "HIV/SIDA: The Epidemic in Tijuana" [Public Affairs] [Health and Medicine] [Show ID: 30004]
Dr. Steffanie Strathdee is associate dean of global health sciences at the University of California, San Diego School of Medicine. Stephen Morrissey, the interviewer, is the Managing Editor of the Journal. S.A. Strathdee and C. Beyrer. Threading the Needle - How to Stop the HIV Outbreak in Rural Indiana. N Engl J Med 2015;373:397-9.
Steffanie Strathdee discusses the HIV and sex workers Series.