Podcast appearances and mentions of Richard Klein

Richard Klein A lighthouse was proposed in 1896 to mark Peck (or Pecks) Ledge, at the east end of the Norwalk Islands in Connecticut. It began operation in 1906 and was the last staffed lighthouse to be built at a waveswept site on Long Island Sound. Its life as a staffed light was relatively short, only 27 years. It's a typical offshore light of the late nineteenth and early twentieth century period, with a cylindrical cast-iron foundation  topped by a "sparkplug" type cast-iron lighthouse. Peck Ledge Lighthouse, photo by Jeremy D'Entremont. Richard Klein cooking at Peck Ledge Lighthouse The lighthouse was sold via online auction in September 2015, and the owner is now Norwalk Art Space. Today's conversation is with artist, writer, and curator Richard Klein. Richard has utilized found objects in his sculptural work since the late 1990s. In early September of 2024 Richard spent a week at Peck Ledge Lighthouse, a residency that was sponsored by the Norwalk Art Space. Richard is also the curator of a new show at Norwalk Art Space. The show is called “Sight and Sound: Artists Consider Long Island Sound.” It opens on June 12th and continues through August 28th.

Join us in this special podcast episode as we explore the career of Richard Klein, recently retired Chief of the Programs and Civil Works Branch at the US Army Corps of Engineers (USACE). With a remarkable 45-year tenure that ended on December 19, Mr. Klein offers a wealth of stories, insights, and inspiration from his journey in civil engineering. Listen as James, Maj. Funkhouser and Mr. Klein delve into topics like professional development in engineering, the value of mentorship, adapting to changes, and building lasting relationships with partners and stakeholders. This episode is a valuable resource for both current engineers and those about to embark on their career path.

#31: Today on the pod, Cam connects with fellow Keyper and VP Sales, Richard Klein. With a career spanning four countries, Richard has worked on iconic global projects including the London 2012 Olympic Village and 1 Hyde Park Residences. He talks about his passion for real estate sales and the hallmarks of a good salesperson: being inquisitive, building relationships, and working hard. He and Cam discuss the lack of bold architecture in Vancouver and explore how the city can improve on a global scale.• 00:00:13 Start time• 00:02:04 London• 00:03:14 Childhood in London• 00:03:37 Sports• 00:04:46 Grand Papi• 00:05:35 Grand Papi the tailor• 00:06:26 Traditional Jewish family dinners• 00:06:54 Starting in Real Estate• 00:08:24 Olympic Village• 00:08:55 Selling multi-million dollar homes/developments in London• 00:12:05 Living in under 500 sqft• 00:14:25 Who is Liz• 00:16:39 Long distance & proposing• 00:18:04 Meeting Liz• 00:23:07 Different sales team structures• 00:25:09 Kids? • 00:25:56 Richards vegan!• 00:26:58 Being disciplined• 00:28:20 Liz and her athletic background• 00:30:19 Working in Dubai• 00:32:12 Dubai Waterfront• 00:34:19 Dubai government re real estate• 00:37:06 Selling armed vehicles• 00:38:17 Getting back to London• 00:40:15 Working smaller is nimbler• 00:40:33 Massive projects vs. the typical• 00:42:34 Selling real estate in prime cities in prime markets• 00:46:11 What makes a great salesperson in the long run• 00:49:03 What can salespeople do better• 00:50:43 Customer care• 00:55:35 Why Vancouver?• 00:57:31 Work-life balance• 01:00:20 Architecture• 01:03:54 Legacy buildings• 01:07:05 Designing from the inside out. Is this the right way?• 01:09:08 Tokyo• 01:10:52 Lab Tech• 01:11:17 End time

Was there ever a time on campus before crop tops and 16-person fish bowl cocktails?Many of us assume that Cornell has always been and will always been the way it was during our 4 years there. Have you ever wondered what it was like in the 60's?Richard Klein, class of 1963, part genius, part frat boy, great conversationalist-- joins us with his Cornell memories. Not sponsored by or affiliated with Cornell University

Amarna is a collective of people, places, things, and actions that transcend us. In this weekly podcast, Mark Harradine will invite a guest to join the conversation. The topic will depend on the guest, but the overarching theme of this podcast is the Amarna Life Style: how do you get in touch with living from your higher virtues. Become part of this community!This week, Mark invited Richard Klein who worked 35 years at Red River Foods to talk about the global loyal relationships and how it is a better way to do business in the long run. If you are interested in our episode, feel free to contact Mark Harradine for more details about our services.Contact Information:Amarna management consulting services: https://amarnamc.com/Mark Harradine's bio: https://www.amarna-group.com/markharradineRed River Foods Website: https://redriverfoods.net/

An eclectic group of guys with a love of Americana folk music are urging audiences to ditch the Covid blues for their high-energy tunes.T-Bone - guitarist and songwriter Gerry Paul, American fiddler Richard Klein, multi-instrumentalist Cameron "Dusty" Burnell, bassist Aaron Stewart and guitar and mandolin player Michael Muggeridge – released their debut album Good 'n Greasy on June 17.The North Island release tour kicks off on Thursday in Wellington and will be at the Turner Centre in Kerikeri on July 4.Gerry and Dusty join Nick Mills in the studio.LISTEN ABOVESee omnystudio.com/listener for privacy information.

Hosted by David Green of The Cultural Alliance Of Fairfield County. Richard Klein - The Artist & The Museum Our May interview was with Richard Klein, Exhibitions Director at The Aldrich Contemporary Art Museum, who is leaving the museum in June 2022. Hear how his own interests as a practicing artist have evolved in parallel ways to his work as a curator. Richard speaks about the 10 years in which he worked with founder Larry Aldrich, and how this unique museum has changed over the 30 years of his tenure. What were some of the most outstanding and controversial of the 100 exhibits Richard has curated and co-curated at the Aldrich, and what exciting projects does he have up his sleeve for his next phase?

Te gast zijn Richard Klein, hoogleraar klimaatadaptie aan het Stockholm Environment Institute en Europarlementariër Mohammed Chahim. En die laten weinig ruimte voor doemdenken, maar willen wel actie om niet net als deze T-Rex uit te sterven. Het is ook de week waarin ... ... de Europese Commissie de "exclusieve bevoegdheid" krijgt om zeer grote onlineplatforms te controleren. Dat is het resultaat van een compromis tussen de lidstaten dat deze week gevonden is. In het oorspronkelijke voorstel zouden de lidstaten de regels gaan handhaven, maar Frankrijk blokkeerde dat, om te voorkomen dat landen als Ierland en Luxemburg, waar de meeste grote techbedrijven hun Europese hoofdkwartier hebben, te makkelijk met de regels zouden omgaan. Dus Frankrijk heeft voor een verzwaring gezorgd. De nieuwe autoriteit wordt een onderdeel van de digitale dienstenwet die consumenten betere online bescherming moet gaan bieden. Samen met de digitale marktenwet. Bedrijven die de regels overtreden zouden een boete kunnen krijgen van minimaal vier tot maximaal twintig procent van hun jaaromzet. Dan heb je het al snel over vele miljarden. Zodra de lidstaten en het Europees Parlement akkoord zijn, treden de regels in heel Europa in werking. De vijfendertigste Europa Podcast Hahn en De Vries houden Brussel, de Europese Unie, Schengen, de eurozone en de rafelranden van ons continent in de smiezen. Naast dé onderwerpen van gesprek ook wekelijks aandacht voor 'muziek' van ons continent. En deze aflevering gaan we naar Roemenië. De hele playlist van deze afgrijselijke eurotrash kun je trouwens hier in onze Spotify-lijst beluisteren. Abonneren In de Europa Podcast schotelen we jou een wekelijkse portie Europese zaken voor. Abonneer je op de podcast via bnr.nl/europapodcast, Apple en Spotify.See omnystudio.com/listener for privacy information.

Episode No. 518 features artist Hugo McCloud and curator Erin Christovale. McCloud's work is on view in "In Relation to Power: Politically Engaged Works from the Collection" at the Nasher Museum of Art at Duke University, which was curated by Marshall Price and Adria Gunter, and is on view through February 13, 2022; and in "Hugo McCloud: from where I stand" at the Aldrich Contemporary Art Museum, which was curated by Richard Klein and is on view through January 2, 2022. McCloud's work engages questions around labor, environmental impacts and global markets and politics often through materials that relate to the people, histories and issues he addresses. He has been featured in group shows at the Studio Museum in Harlem and at The Drawing Center in New York. His work is in the collection of museums such as the Detroit Institute of Arts, the Smithsonian's National Museum of African American History and Culture, and the North Carolina Museum of Art. On the second segment, Christovale discusses the retrospective "Ulysses Jenkins: Without Your Interpretation," which is at the Institute of Contemporary Art, Philadelphia through December 30, 2021. Christovale co-curated the exhibition with Meg Onli. Jenkins is an influential video and performance artist whose work has examined how cultural iconography and history have informed representation.The exhibition will travel to the Hammer Museum, Los Angeles next year. The exhibition catalogue was published by the two museums. Indiebound and Amazon offer it for about $40. The museums will also republish Jenkins's memoir, "Doggerel Life: Stories of a Los Angeles Griot."

A discussion with artist/curator Richard Klein about his new project The Understory. You can see some of the images from the exhibition on Instagram at https://www.instagram.com/richardklein67/ The exhibition is taking place at the Icehouse in Sharon, Connecticut, and it opens on September 25, 2021. https://www.k2kozik.com/icehouse-project-space

Kennst Du die Speed & Geeking Veranstaltungen vom eLearning Journal? Am 30. Juli gab ich dort meine Premiere als Moderatorin und kündigte Richard Klein von evonik an.    Dieser sprach in seiner Keynote über das Thema selbstgesteuertes Lernen. Dabei stellte er auch vier Fragen, die ich Dir hier mitgebracht habe.   Die Veranstaltungen vom eLearning Journal sind immer ein voller Erfolg mit ganz tollen Beiträgen und Speakern. Aus dem Grund empfehle ich Dir diese sehr gerne weiter.   Des weiteren erhält Du hier auch ein paar Einblicke in meine Weiterbildung. Wieso ich mich seit über 20 Jahren ständig weiterbilde und warum ich die Prüfung zum Scrum Master PSM I absolviert habe.   Inhalt:

 About This Episode: In this week’s podcast, we visit with Judge RIchard Klein, a distinguished jurist who served as a judge for 36 years. In fact, when he became a judge at age 32, he broke his father’s record of being the youngest lawyer in Pennsylvania history to become a judge.  Currently serves as an arbitrator, mediator, and trial & appellate consultant with The Dispute Resolution Institute headed by Harris Boch.   Judge Klein shares his interest in music, travel and his obligation to give back. Yet, as the title of this episode indicates, his most significant role is that of being a father to his three sons, and a grandfather to his six grandchildren.  As one of his sons, I am both honored to share this conversation.  Connect with Judge Richard Klein: Dispute Resolution Institute JudgeKlein.com   Connect with nine dots: E-mail Geoffrey nine dots Media Twitter Instagram LinkedIn Facebook

Guests: Michael Orcutt, Vice President of Sales and Engineering, CosaTronRichard Klein, Senior Product Marketing Manager, OSIsoftDaniel Noonen, Partner Solution ArchitectIndustry: FacilitiesBusiness Impact: Safety, environmental quality.A manufacturer of advanced air purification systems can now monitor and provide analysis of indoor air quality remotely. In our latest podcast listen to Michael Orcutt of CosaTron describe a project with OSIsoft that uses only OSIsoft Cloud Services (OCS) to view, analyze and store on the cloud indoor air quality data. He is joined by the OSIsoft engineer who did the work, Daniel Noonen, and OSIsoft marketing manager and OCS specialist Richard Klein.

If you follow Kentucky racing at all, you are surely familiar with the lime green and black diamonds of Klein Racing. They've campaigned numerous stakes winners dating back to Hurricane Bertie and Outofthebox to fast fillies such as Break Even. Richard Klein, the owner and operator of Klein Racing joins us to reminisce about some of the stable's conquests. Success Story by Mixaund | mixaund.bandcamp.com Music promoted by www.free-stock-music.com

Prawn numbers are mysteriously dropping off at Taupō's iconic Huka Prawn Park.It's been a recurring issue over the last few years, with this year being harder hit than previous years, and despite extensive scientific research and monitoring, the cause is still unknown.Huka Prawn Park has been breeding prawns for the last 30 years. It all began with a vision of researching and developing the ability to breed and grow tropical prawns in captivity using geothermal heat from the Wairakei geothermal power station next door to the park.The park, which is located on the banks of the upper Waikato River in Taupō, has developed over the years beyond prawn breeding to become a popular family attraction.It has entertained thousands of visitors over the years, including with its unique prawn fishing, says co-owner Richard Klein"They're tricky little beggars to catch and have certainly kept everyone entertained."But Richard has now been forced to make a heartbreaking decision to temporarily close the prawn fishing part of the park."I'm devastated," Richard says. "But we, along with our consulting scientists are truly baffled about what is happening to the prawns. And for some reason the issues are worse in summer."

Guests: Dr. Richard Klein, Physician, Attorney, an expert with the Regulatory Transparency Project's FDA and Health Working Group on to discuss concerns about a "second wave" of COVID-19 pandemic Katherine Gehl, Founder of the Institute for Political Innovation, entrepreneur and author on to discuss her book "The Politics Industry" Dr. Steve Hotze, Physician, Radio Host, and Best Selling Author on to discuss the epidemiological risks of President Trump's rally Saturday in Tulsa, OK and your calls

A discussion with Richard Klein, curator of the exhibition "Weather Report" at Connecticut's Aldrich Museum of Contemporary Art in Ridgefield: 'Weather Report will reveal the sky as a site where the aesthetic, the romantic, the political, the social, and the scientific co-exist and inform one another. The depiction of weather phenomena in the visual arts is traditionally linked with either landscape painting or photography, but in the last two decades artists have increasingly turned to other media to explore weather and, by extension, the larger subject of the Earth’s atmosphere. Featuring the work of Bigert & Bergström, Barbara Bloom, Sara Bouchard, Josh Callaghan, Nick Cave, Violet Dennison, Bryan Nash Gill, Andy Goldsworthy, Nancy Graves, Ellen Harvey, Ayumi Ishii, Jitish Kallat, Kim Keever, Byron Kim, Damian Loeb, Iñigo Manglano-Ovalle, Colin McMullan, Hitoshi Nomura, Pat Pickett, Sean Salstrom, and Jennifer Steinkamp, and an installation by researchers Amanda Bunce, Joel Salisbury, and Michael Vertefeuille." http://aldrichart.org/article/weather-report

Richard Klein served as editor for the PNAS Special Feature titled "Out of Africa". This collection of articles explores the historical expansion of Homo sapiens from Africa to Eurasia. The Special Feature, along with an editorial by Dr. Klein, will publish in the September 22 issue of PNAS.

Aaron Freiwald, Managing Partner of Freiwald Law and host of the weekly podcast series Good Law | Bad Law, is joined by veteran judge and body language expert Richard Klein. On our show today, we are talking about body language both in the courts and out. Judge Klein tells us about his experiences from nearly 40 years on the bench watching jurors and attorneys and how they interact with each other. He explains the importance of non-verbal communications and how this translates into interactions outside the courtroom. Judge Klein also serves as founding co-chair of the Pennsylvania Bar Plain English Committee and Pennsylvania House of Delegates. He has served as an adjunct professor at the Temple University Law School for 15 years and he is also an author who has written about body language in the book, “Trial Communication Skills, written with Body Language” with co-authors Julius Fast and Roberto Aron. Remember to tune in every Friday for new episodes of Good Law | Bad Law! Host: Aaron FreiwaldGuest: Judge Richard Klein Follow Freiwald Law:Twitter: @FreiwaldLawFacebook: @FreiwaldLawYoutube: Good Law | Bad LawInstagram: @goodlawbadlawWebsite: http://www.freiwaldlaw.com

It's a classic American success story - Richard Klein started his business out of the back of a truck and grew it to a place of success over the years. In fact, he was recently honored by the Los Angeles Chamber of Commerce as small business person of the year. In this podcast Richard shares his secrets of success, work philosophy, daily habits and book recommendations. Thanks for listening! Find out more about Richard and his work at elinbarton.com/podcast

Richard Klein is the President and CEO at Advanced Battery Systems in Culver City, California. ABS is a leader in the automotive, high performance and industrial markets. With over 30 years of experience providing UPS systems, generators, industrial power backup systems, batteries, and accessories Richard and his talented team offer a wealth of experience. They are Southern California’s largest battery supplier and distributor and their line of products is extensive. Their services include design and installation, maintenance, and recycling. Richard serves on several industry boards and helps mentor small business owners.

Researchers at the University of California, Berkeley have created a novel simulation visualizing over 700,000 years of star formation. The project took several months on NASA’s supercomputer, for a total of 1 million hours across thousands of processors. Since this sort of simulation is so computationally intensive, astrophysicist Richard Klein used a mathematical technique called “adaptive mesh refinement” to focus in on certain aspects of the evolving stars. "This enables you to select what regions of a large-scale computational domain you want to focus on in a simulation, and enable you in a dynamic way to have high resolution in those areas that are critically important for understanding the astrophysical phenomenon, while letting other regions of the computation be at much lower resolution and therefore lower cost." Before this technique, Klein says this type of simulation would have been computationally impossible.

A new supercomputer simulation is helping scientists visualize the evolution of stars. The NASA-funded project is based on code written by astrophysicist Richard Klein of the University of California, Berkeley and the Lawrence Livermore National Lab. According to Klein, this simulation is one step towards a comprehensive theory of star formation, which begins when a cloud of interstellar gas collapses under gravity. "So we start with these turbulent magnetized clouds. Follow the cloud for up to a million years of evolution, all the way to the point where stars can form in clusters." Klein turns to observations of real stars to check the results. "We begin to calculate what the properties of those stellar clusters are in great detail and then compare the properties that we get from the large scale simulations with what the observations are actually telling us." The team is currently working towards even larger-scale simulations.

Talking TV catches up with the big winners from the Broadcast Awards and puts ITV’s commissioning changes in the spotlight. Winners including Rob Delaney, Jay Hunt, Pete Bowker and the Have I Got News For You boys talk to host Jake Kanter after receiving their gongs. Elsewhere, Broadcast’s Alex Farber and Steven D Wright discuss Richard Klein’s departure from ITV and safety measures on The Jump. Finally, there are previews of ITV's It's Not Rocket Science and Airmageddon on CBBC.

How do you learn compassion? Can meditation teach you? Or does it have to come from your own suffering? Maybe a combination of both? I know well how my own experiences of a broken heart have pierced the veil of selfishness and opened me to the needs, pain, and suffering others. But do we have to live with a broken […] The post OM 020: Learning Compassion Through Tibetan Buddhism with Richard Klein appeared first on About Meditation.

Live from the bus, Dave and Diana discuss Frasier Episode 106, The Crucible, starring Richard Klein and Not The Brain. Splash a little in the …

Richard Klein and Jerry Adler are veteran actors and directors on stage, television, and film. You might know Klein as Dallas on Three's Company, and Adler as "Hesh" on The Sopranos. On this show, they'll visit the WNPR studios to tell their stories, and reminisce with Colin about his years as Ed the Handyman on Charles In Charge.That's not true, Colin wasn't in Charles In Charge, but we'll explore the nuances of theater acting, the history of their time on television, and get a sneak peek at their latest work together, "The Sunshine Boys" at the Jorgensen Theater at UConn.Support the show: http://www.wnpr.org/donateSee omnystudio.com/listener for privacy information.

With Richard Klein The recently released working group II section of the fifth IPCC assessment report analyses the impacts of climate change, the various vulnerabilities of mankind and nature, and features and expanded elaboration of the potential as well as the limits of adaptation. Prof. Richard Klein from the Stockholm … more >>

Chances are that your neighborhood will change, and new buildings will rise. So what else is knew? Well, if it takes place next door to your co-op or condo, there’s stuff you need to do - and quick. Listen as two attorneys, C. Jaye Berger and Richard Klein, both solo practitioners in their eponymous New York law firms, advise a Brooklyn board president on steps to take when the adjacent parking lot is no longer for parking, but is awaiting construction.

Zoologist Toni Bodi is currently developing a genomic diagnostic screen for Alzheimer’s disease and is a founding member of the Berkeley Bio Labs new bio hacker space. Nature magazine.TranscriptSpeaker 1: Spectrum's next. Speaker 2: Aw. [inaudible] [inaudible] [inaudible] [inaudible] [inaudible]. Speaker 1: Welcome to spectrum the science [00:00:30] and technology show on k a l x Berkeley, a biweekly 30 minute program bringing you interviews featuring bay area scientists and technologists as well as a calendar of local events and news. Speaker 3: Hi and good afternoon. My name is Brad Swift. I'm the host of today's show. Our guest is Tony Bodhi Hickerson, a zoologist who was part of a cognitive study of howler monkeys in Mexico. Tony is trying to organize a noninvasive [00:01:00] dolphin study in the wild using wireless network technology. She is currently developing a genomic diagnostic screen for Alzheimer's disease and is a founding member of the Berkeley bio labs, a new bio hackerspace. Tony talks about cognition, Alzheimer's disease, and creating a scientific community resource in the bay area. Rick Karnofsky and Renee Rau interview Tony on this edition of spectrum. Speaker 4: So welcome to spectrum. [00:01:30] I'm Rick Karnofsky here with Brad swift and Renee Rao. Our guest today on spectrum is Tony Bodhi, Hickerson and zoologist. Welcome to spectrum. Thank you for having me. Can you give us a little bit of a description of what you work on? Kind of a brief overview for the audience. That cognition is essentially the ability to receive and process information and the most abstract form. And we kind of think of it as mental processes, which can be both conscious and subconscious. [00:02:00] And so I do research on cognitive abilities of wildlife and at the moment I'm also working on an application in humans. What wildlife do you look at? Um, well I have looked at primates and I've been also involved in a dolphin project. So high functioning mammals. And how do you assess their cognitive abilities? Well, you can do behavioral studies, which is what I primarily do. Speaker 4: And of course just looking at the anatomy as well. So [00:02:30] I try to be as noninvasive as possible. I don't work in a lab with monkeys in a cage. I actually work in the wilderness and follow monkeys around all day. So where do you do that? I was doing that in Mexico for my last study with seven months and from Sunup I watched the sun come up and uh, the howler monkeys, which is a species that I was working on would call in the morning. That's how we'd find them. So we trek through the jungle and find them and then start our study. And it would usually last, well it would last until sundown. So depending on how many hours a like we had [00:03:00] [inaudible] Speaker 5: can you just walk us through what the study was and what you looked at in the howler monkeys and how you interpreted it? Speaker 4: Well, this study, I was a, the head field managers, so it wasn't my particular study, but I was managing all the data collection and uh, we were looking at two different species of Holler monkey. And they're hybrids. So there's hybrid zone in Mexico where both of these species, which we believe based on genetic evidence have been separated for about 3 million [00:03:30] years. They have different number of sex chromosomes. They're very morphologically different, are coming together and meeting successfully. They also have very different social structures and one group tends to be far more aggressive than the other one is much more communal. It has large groups up to 25 30 and the other one usually has three to five. So to see how behaviorly they come together and genetically they come together because in one cross if you have a female of a and a male of B, they can [00:04:00] have an offspring. But if you inverse it they cannot. So it's really interesting also genetically to see how things recombine. What kinds of data did you take? Oh, we took auditory, so we, they're hollow monkeys. So we had all their calls, which it changes from group to group and obviously from species to species. We also took a lot of behavioral information, affiliative, so like affection and aggressive behavior, like attacks and genetic [00:04:30] information through and study captures as well as fecal samples. Speaker 5: I'm just super curious about what it was like following the Heller monkeys and spending literally all day with them. You, Speaker 4: I started to go insane. You actually do. Um, no, it was a really profound life experience for sure. And I couldn't have designed a better project to be part of. Like if I had designed my dream project, it would have been this project. When I started this project, I didn't speak Spanish and [00:05:00] every single person in my team only spoke Spanish, so I learned Spanish very fast. But during the process of learning a second language, you have this inability to completely express yourself and it kind of makes you go insane. And then when you couple that with standing in the middle of like a really humid forest, you know, surrounded by mosquitoes and following monkeys running through the canopy. I got you about month five I think, and I realized that I started to go insane. [00:05:30] When I yelled at an ant out loud, I paused and just laughed hysterically to myself and realize that like this is the point where like I've reached my mental break. Then I'm yelling at ants and I need to get to a city as soon as possible. Speaker 2: Okay. Our guest today on spectrum is Tony Bodhi Hickerson, but she answers to Tony Bodhi in the next, she talks about her idea for a dolphin stone. [00:06:00] This is k a l x Berkeley. Speaker 4: And what do you do with the dolphins? Uh, the Dolphin project, uh, is not a field project, unfortunately at the moment. It's an education campaign for the international mantle project, which is responsible for all dolphin safe tuna that you've ever seen as well as the documentary, the cove. So they're very avid group on [inaudible]. [00:06:30] And so I was putting together a campaign to try and inspire people that they're really intense creatures and why maybe we should respect them. Speaker 5: You tell us a little bit about those abilities and why they're so intense. Speaker 4: There are three groups of mammals that have large brains that's great. Apes, elephants and marine mammals. And the dolphins came from a very different evolutionary path. So they have different [00:07:00] structures, which is also really interesting. They don't have the prefrontal Cortex, which is what we tend to associate with being human, the sort of emotional side of being human. But they have a very intense limbic system, which is also associated with emotions and bonding behavior and sexual behavior. Dolphins have sort of this mixed reputation of being very kind of aggressive and also being really altruistic almost in their actions. [00:07:30] So looking at not only the hard facts of the biological side of things of like what structures they have and what those abilities are, but also case studies of look at these sort of altruistic behaviors. So their ability to perceive the world around them and to react in an emotional state is potentially really profound. Speaker 5: And um, in your study to sort of understand all the ways that the Dolphin perceives the world and the way that it often feels these things, are you looking at the structures in their brains and seeing [00:08:00] the corresponding place where these thought processes and these perceptions happen? Or are you just observing behavior or are you doing both? Speaker 4: Well, hopefully both. So I'm currently designing a project, which is hopefully gonna do exactly what you just said. Our tools at the moment are very limited, especially because we want to be as noninvasive as possible. Animals don't react in captivity the way that they react in the wild. And obviously they don't have the same space or social structure to be able to do the same sorts of things. [00:08:30] There is an up and coming technology that I hope to apply to this sort of research which would allow biological data to be recorded in real time and it would be completely noninvasive. It would be almost like a sticker, so there'd be no puncturing. There would be no need for captivity. Hopefully we could even apply it with minimal stress to the animal and with that we could have gps data body, we could potentially record the vibrations from their echolocation [00:09:00] and also neurological data and this would be the first information of its kind to be able to correlate if there's an approach or an affiliative behavior between two individuals, what areas of their brain are actually being, you know, lit up and that could really profoundly affect what we know about their structure. Speaker 4: Yeah, that that is sounds really exciting. So it would be noninvasive. Do you know how that works? That must be really amazing. The technology that I'm, I'm hoping to work with [00:09:30] is a flexible microchip and I'm hoping to be working with some of the innovators to make it appliable to dolphins and something that would stick for up to a month. They should scan very quickly, so that is a restraint. I don't know as much of the engineering side of it because I'm not as much tech, but from my conversations with the people developing it, it seems like it might not be up to use for a year or two, but hopefully eventually we'll get [00:10:00] there and we'll have a better understanding of how one of the smartest animals on the planet. Thanks. Are other people currently doing anything more invasive? Captivity can be a very invasive process. How animals and captivity get in captivity are often from Dolphin Slaughters, which kill hundreds of their fellow pod mates to get a handful of dolphins because a live dolphin that is pristine, [00:10:30] you know mark free that goes into entertainment or goes into a laboratory studies. They get taken out and they get sold for hundreds of thousands of dollars and the rest of them get slaughtered and sold into the meat markets. Speaker 6: Mm MM. Speaker 3: You are listening to spectrum on k a l x Berkeley. Our guest today is Tony Bow-tie Hickerson. Tony is a zoologist. In the next segment she talks about diagnosing Alzheimer's disease. Speaker 4: [00:11:00] I actually wanted to ask you a little bit about the work you're doing with Alzheimer's and dice diagnostic work. Could you maybe tell us a little bit about how the process of diagnosing Alzheimer's works currently and what you're hoping to change about that? Well, there really isn't much in terms of diagnosis that's out for the general public. What I'm actually attempting to do, and initially it was for my own curiosity and you know obviously see the potential for other people to use it as [00:11:30] well. I wanted to test myself on this gene. So there is a gene called apoe e and there are three expressions of it and they account for about 95% of all Hymers, one of these types of accounts for 50% of all hammers. I can essentially locate this gene snippet out of the enormous strand of DNA and then look at their two spots where [00:12:00] the nucleotide is a certain sequence that I can tell you. Speaker 4: If that is type one, two or three of that apathy and off of that, they're very strong statistics that will tell you that you have a very high likelihood or very low likelihood of getting Alzheimer's by a certain age. And it's sort of a spectrum due to the fact that we're deployed. So we have two copies of this gene. So if you have this like really strong negative version and one positive version, you will [00:12:30] have later onset Ohio Hymers. Then if you have two really negative versions, but there are really strong numbers that tell us what your likelihood is. But what I would like to do is to make it something that's very accessible for everyone. I don't want to produce this and market it as some expensive tests that's going to just perpetuate this whole medical debt system. I want this to be something that people can access and know for themselves to be able to plan [00:13:00] for their own future and to be able to take care of themselves and their family members more effectively and responsibly. Speaker 4: So it's pretty similar to the aggressive cancer testing would you say? Or? Um, yeah, it's fairly similar. I haven't looked exactly at that one to see. I believe it is also a snip, which is like this single nucleotide change. So it should be very similar. Do you want to tell us a little bit about the process of you sort of isolating this gene? Did you go through and read the papers [00:13:30] and see that this gene was associated with it and develop the processes snippet on your own or I'm in the process of developing the process to snippet. So right now I'm troubleshooting the primer. So the, the molecule that you use to actually cut the DNA, what I have is currently binding to itself. So it is also binding to the site that I want it to, but it's also binding to itself. So I'm trying to sort that issue out. Speaker 4: It's a process that needs to be critiqued a bit before. I'm willing to, you know, expose more [00:14:00] people to the answers cause I want to make sure that it is very accurate before I would to give someone those sorts of answers. You're currently doing some form of genetic screening and you previously did all of these behavioral studies. It's quite a transition. So how, how did you make that transition? Well they're both in principle based on cognition, mental abilities and so all Hymers is the degradation of cognitive abilities, the degradation of being able to recall information as well as [00:14:30] the breakdown of even motor skills and language skills and so that is profoundly interesting to me to to understand where and how cognitive abilities act and then to understand how they're dismantled is the cycle of, of the process of understanding exactly how things work. A lot of times we figure out what parts of the brain do what based on lesion studies, which is causing and disruption. Speaker 4: The initial draw [00:15:00] to this was for my own curiosity. And that was sparked because my father has severe dementia. So I wanted to know for him, is this all Hymers or is it something environmental? And so I want to develop a test for him, for myself and for the public to know what's their likelihood so that they can plan for the future. Are there other differentiating factors you could look at as well besides this, besides this gene? So the gene is pretty profound and [00:15:30] it's significance in whether or not people get all hammers. But there's, there's also, you know, of course a lot of different factors and I should mention that like echoey is a specific kind of all hammers. It's not early onset and not all dementia is Alzheimer's. There's lots of ways to get dementia in old age. So this isn't like a yes, no test. Speaker 4: If you have a really great diagnostic and it looks like you're clear for this, it doesn't mean that when you hit 80 that you're not gonna have problems [00:16:00] still. You still have to take care of yourself. And a lot of studies have shown that simple things and everyone says this, but simple things like diet and exercise. If you exercise on a regular basis, you can break down a lot of these corrosive molecules that cause a lot of mental problems, cause a lot of cardiovascular problems and you have to keep your metabolism up to deal with this and your body will also, you know, work to heal itself. It's just really profound what control you have over your future. [00:16:30] Like I don't want to give people this test and say you're doing, I feel that you two have a lot more control than a lot of people want to admit over the future. And so take responsibility for yourself and take care of your body. Go exercise and eat well and have lots of friends and learn new languages and go travel. See the world Speaker 2: spectrum is a science and technology show on KALX Berkeley. Our guest [00:17:00] today is Tony Bodhi Hickerson in the next segment that Tony talks about, the new Berkeley Bio lab. Speaker 4: So you're involved in a biohacker space. Uh, yes. So actually as of last weekend we moved into a space in Valeho which is my n when the other core members lab on the, hopefully we will be also opening a space [00:17:30] in Berkeley eventually, but for now we're in relay hope and it's essentially like a hacker space, but it's in biotech in general and you pay a membership and you have access to the lab and the materials to do your own research, detached from corporate biases and the strains of academia. So we provide a space in the community to kind of teach each other and [00:18:00] to work in and we allow real hard science to take place and sort of a pioneer setting. What's the name of it and how does it compare it to bio curious and some of the other spaces in the bay area? Speaker 4: Sure. The name of the lab is going to be Berkeley bio labs. Some of the other entities that will be occurring within this lab is a June cell technologies. We're trying to be much more accessible in that our membership [00:18:30] is only going to be $100 a month, whereas a lot of other bio spaces are $2,000 and up a month. I think that having more spaces isn't necessarily a bad thing. We tend to be a little bit more focused on regenerative medicine and stem cell research, so people who are more focused along that lines might be more attracted to work with us, but certainly weren't. We're not discriminating against people who aren't in stem cell research or regenerative medicine. That's just what we tend to do. I shouldn't ask you if you could [00:19:00] tell us a little bit more about the projects that are happening in the space now. Speaker 4: At the moment, we haven't even opened up yet. We were literally still moving all of the giant centrifuges and automated robots. And so right now I'm is my project as well as John's London, which is one of the founding members of the biohacker lab and he works in regenerative medicine and stem cells. [00:19:30] And once we kind of get settled and open our doors, we'll hopefully be screening lots of potential innovators to come and join our project and not necessarily his project but you know, whatever inspires them to try and you know, make a difference. And what will that screening process look like? It'll honestly be very personal. We're going to just meet with people one on one and see what they're interested in doing, what they have done and what they want to see in the future. It's much more about the people and [00:20:00] their drive to do something than the letters after their name. Speaker 4: We all feel that someone who's really driven to take the four or five years after a bachelor's and do their own research potentially has a lot more to offer than someone who might not know what they want to do in his just signing up for pastry. Cause they feel like it's the next step. So we're definitely open to pioneers, innovators and people who are willing to scrap to make a change. How are you getting the word out about the a space? [00:20:30] Well, actually the, the first thing that has happened so far on the 24th I believe it was, we had a paper written about us in nature. And so that was the first real publicity, and this is the second. So the article was called biotechnology independent streak. If anyone cares to look it up in the July 24th issue, it's gotta be super expensive to have all of the high mated robots and the giant centrifuge. Speaker 4: How are you financing [00:21:00] the space? All of the equipment is already owned by John. He's been working in biotech for quite some time and it has accumulated a very impressive stock of machinery and equipment and he's more than happy to share, to enable other people. He's been really phenomenal and assisting me and getting into a lab space, she's really enabled me to be able to do research that I would never be able to do on my own. And he's doing that for hopefully a lot of other people and so [00:21:30] I would hope to perpetuate that and help people get into it and start making a difference. What do you anticipate the future of the hackerspace pain? Well, we hope that we find lots of driven people who want to come and we are overflowing with scientists until we need to open up another space. I would love to see this be a scientific movement. Speaker 4: Science is all about curiosity. It's about having a question and figuring out how to find the answer and I think that that's [00:22:00] something in our education system that a lot of times is not really taught. People are taught facts, they're not taught. How do you figure facts out? You know? It's not about memorization. It's about teaching yourself how to think. How did you get into science? I have always been profoundly curious, but actually I started out as an art major and about two and a half years in I got called into my advisor's [00:22:30] office and I said, you can't take any more science classes. Told me you filled up all your electives and another semester. And if you take another science class, then we're going to kick you out of the fine arts school. So I said, okay. And I put in an application at another university and switched into science because I thought it was completely absurd that they would hinder me from taking science classes, but it was just a curiosity to understand how [00:23:00] the molecular and biological world works. Understand, you know, how life happens and how stars are born. It's something that I don't understand why every single person doesn't have this profound emotional response to understanding all Tony, thanks for joining. Yes, thank you. Speaker 2: Oh, [inaudible]. If you can not always catch spectrum broadcasts, know that shows are archived [00:23:30] on iTunes university, we have created a simple link to the archive just for you. The link is tiny url.com/calyx spectrum. No, a few of the science and technology events happening locally over the next two weeks. Rick Karnofsky and I present the calendar. Speaker 3: Tuesday. August 27th the UC Berkeley Botanical Gardens [00:24:00] will host a guided butterfly walk. Join Sally Levinson, the gardens resident caterpillar lady on a walk through the amazing collections of the botanical garden in search of butterflies to register for a butterfly walk, which is free with admission email garden@berkeley.edu the butterfly walk will be held from three to 4:00 PM on Tuesday, August 27th at the UC Berkeley Botanical Gardens. At this month, [00:24:30] actual science, you can learn how the properties of diamonds are uniquely suited for scientific research. Christine beavers is a research scientist based at the advanced light source at Lawrence Berkeley National Lab. Her specialty is crystallography, which is the determination of 3d structures of molecules from crystals using x-rays. Actual science will be on Thursday, August 29th at 6:00 PM [00:25:00] at actual cafe six three three four San Pablo Avenue in Oakland and mission is free. UC Berkeley is holding its first monthly blood drive of the school year on August 29th you can make an appointment online, but walk-ins are also welcome. Speaker 3: You are eligible to donate if you are in good health way, at least 110 pounds and are 17 years or older. The blood drive will be on Thursday, August 29th in the Anna had [00:25:30] alumni house on the UC Berkeley campus. It will last from 9:00 AM to 3:00 PM you can make an appointment or find more information at the website. Red cross.org using the sponsor code you see be wonder fest and ask a scientist present the neuroscience of magic on Wednesday, September 4th at the [inaudible] street food park, 48 [00:26:00] 11th street in San Francisco. You CSF professor of neuroscience, Adam Gazzaley and the comedy magician, Robert Strong. We'll lead discussions from ancient conjurers t quick handed con artists, two big ticket Las Vegas illusionists magicians. Throughout the ages, I've been expertly manipulating human at attention and perception to dazzle and delight us. [00:26:30] Of course, you know that the phenomenon of cognitive and sensory illusions are responsible for the magic, but you've got to admit it still kind of freaks you out when some guy in a top hat defies the of nature right in front of your eyes. The event is free. Now, two news stories. Speaker 3: Berkeley News Center reports a new theory by fluid dynamics experts at the University of California Berkeley shows how Zombie vorticies [00:27:00] help lead to the birth of a new star reporting in the journal Physical Review Letters, a team led by computational physicist Philip Marcus shows how variations in gas density led to instability, which generates the whirlpool like vorticies needed for stars to form. The Zombie reference is an astronomical nod to pop culture and because of the so called dead zones in which these vorticies exist, this new model has caught the [00:27:30] attention of Marcus's colleagues at UC Berkeley, including Richard Klein, adjunct professor of astronomy and fellow star formation expert, Christopher McKee, UC Berkeley professor of physics and astronomy. They were not part of the work described in physical review letters but are collaborating with Marcus to put the Zombie vorticies through more tests. Science daily reports the identification of what may be the earliest known [00:28:00] biomarker associated with the risk of developing Alzheimer's disease. Speaker 3: The results suggest that this novel potential biomarker is present in cerebral spinal fluid at least a decade before signs of dementia manifest. If our initial findings can be replicated by other laboratories, the results will change the way we currently think about the causes of Alzheimer's Disease said Dr Ramon true? Yes. Research professor [00:28:30] at the CSIC Institute of Biomedical Research of Barcelona and lead author of the study that was published in annals of neurology. This discovery may enable us to search for more effective treatments that can be administered during the preclinical stage. These C S I c researchers demonstrated that a decrease in the content of micro chondrial DNA in cerebral spinal fluid may be a preclinical indicator [00:29:00] for Alzheimer's disease. Furthermore, there may be a direct causal relationship Speaker 6: [inaudible].Speaker 1: The music hub during this show was written and produced by Alex Simon. Thank you for listening to spectrum. If you have comments about the show, please send them to us via email. Address [00:29:30] is spectrum dot k. Alright. yahoo.com join us in two weeks at this same time. [inaudible]. See acast.com/privacy for privacy and opt-out information.

Zoologist Toni Bodi is currently developing a genomic diagnostic screen for Alzheimer's disease and is a founding member of the Berkeley Bio Labs new bio hacker space. Nature magazine.TranscriptSpeaker 1: Spectrum's next. Speaker 2: Aw. [inaudible] [inaudible] [inaudible] [inaudible] [inaudible]. Speaker 1: Welcome to spectrum the science [00:00:30] and technology show on k a l x Berkeley, a biweekly 30 minute program bringing you interviews featuring bay area scientists and technologists as well as a calendar of local events and news. Speaker 3: Hi and good afternoon. My name is Brad Swift. I'm the host of today's show. Our guest is Tony Bodhi Hickerson, a zoologist who was part of a cognitive study of howler monkeys in Mexico. Tony is trying to organize a noninvasive [00:01:00] dolphin study in the wild using wireless network technology. She is currently developing a genomic diagnostic screen for Alzheimer's disease and is a founding member of the Berkeley bio labs, a new bio hackerspace. Tony talks about cognition, Alzheimer's disease, and creating a scientific community resource in the bay area. Rick Karnofsky and Renee Rau interview Tony on this edition of spectrum. Speaker 4: So welcome to spectrum. [00:01:30] I'm Rick Karnofsky here with Brad swift and Renee Rao. Our guest today on spectrum is Tony Bodhi, Hickerson and zoologist. Welcome to spectrum. Thank you for having me. Can you give us a little bit of a description of what you work on? Kind of a brief overview for the audience. That cognition is essentially the ability to receive and process information and the most abstract form. And we kind of think of it as mental processes, which can be both conscious and subconscious. [00:02:00] And so I do research on cognitive abilities of wildlife and at the moment I'm also working on an application in humans. What wildlife do you look at? Um, well I have looked at primates and I've been also involved in a dolphin project. So high functioning mammals. And how do you assess their cognitive abilities? Well, you can do behavioral studies, which is what I primarily do. Speaker 4: And of course just looking at the anatomy as well. So [00:02:30] I try to be as noninvasive as possible. I don't work in a lab with monkeys in a cage. I actually work in the wilderness and follow monkeys around all day. So where do you do that? I was doing that in Mexico for my last study with seven months and from Sunup I watched the sun come up and uh, the howler monkeys, which is a species that I was working on would call in the morning. That's how we'd find them. So we trek through the jungle and find them and then start our study. And it would usually last, well it would last until sundown. So depending on how many hours a like we had [00:03:00] [inaudible] Speaker 5: can you just walk us through what the study was and what you looked at in the howler monkeys and how you interpreted it? Speaker 4: Well, this study, I was a, the head field managers, so it wasn't my particular study, but I was managing all the data collection and uh, we were looking at two different species of Holler monkey. And they're hybrids. So there's hybrid zone in Mexico where both of these species, which we believe based on genetic evidence have been separated for about 3 million [00:03:30] years. They have different number of sex chromosomes. They're very morphologically different, are coming together and meeting successfully. They also have very different social structures and one group tends to be far more aggressive than the other one is much more communal. It has large groups up to 25 30 and the other one usually has three to five. So to see how behaviorly they come together and genetically they come together because in one cross if you have a female of a and a male of B, they can [00:04:00] have an offspring. But if you inverse it they cannot. So it's really interesting also genetically to see how things recombine. What kinds of data did you take? Oh, we took auditory, so we, they're hollow monkeys. So we had all their calls, which it changes from group to group and obviously from species to species. We also took a lot of behavioral information, affiliative, so like affection and aggressive behavior, like attacks and genetic [00:04:30] information through and study captures as well as fecal samples. Speaker 5: I'm just super curious about what it was like following the Heller monkeys and spending literally all day with them. You, Speaker 4: I started to go insane. You actually do. Um, no, it was a really profound life experience for sure. And I couldn't have designed a better project to be part of. Like if I had designed my dream project, it would have been this project. When I started this project, I didn't speak Spanish and [00:05:00] every single person in my team only spoke Spanish, so I learned Spanish very fast. But during the process of learning a second language, you have this inability to completely express yourself and it kind of makes you go insane. And then when you couple that with standing in the middle of like a really humid forest, you know, surrounded by mosquitoes and following monkeys running through the canopy. I got you about month five I think, and I realized that I started to go insane. [00:05:30] When I yelled at an ant out loud, I paused and just laughed hysterically to myself and realize that like this is the point where like I've reached my mental break. Then I'm yelling at ants and I need to get to a city as soon as possible. Speaker 2: Okay. Our guest today on spectrum is Tony Bodhi Hickerson, but she answers to Tony Bodhi in the next, she talks about her idea for a dolphin stone. [00:06:00] This is k a l x Berkeley. Speaker 4: And what do you do with the dolphins? Uh, the Dolphin project, uh, is not a field project, unfortunately at the moment. It's an education campaign for the international mantle project, which is responsible for all dolphin safe tuna that you've ever seen as well as the documentary, the cove. So they're very avid group on [inaudible]. [00:06:30] And so I was putting together a campaign to try and inspire people that they're really intense creatures and why maybe we should respect them. Speaker 5: You tell us a little bit about those abilities and why they're so intense. Speaker 4: There are three groups of mammals that have large brains that's great. Apes, elephants and marine mammals. And the dolphins came from a very different evolutionary path. So they have different [00:07:00] structures, which is also really interesting. They don't have the prefrontal Cortex, which is what we tend to associate with being human, the sort of emotional side of being human. But they have a very intense limbic system, which is also associated with emotions and bonding behavior and sexual behavior. Dolphins have sort of this mixed reputation of being very kind of aggressive and also being really altruistic almost in their actions. [00:07:30] So looking at not only the hard facts of the biological side of things of like what structures they have and what those abilities are, but also case studies of look at these sort of altruistic behaviors. So their ability to perceive the world around them and to react in an emotional state is potentially really profound. Speaker 5: And um, in your study to sort of understand all the ways that the Dolphin perceives the world and the way that it often feels these things, are you looking at the structures in their brains and seeing [00:08:00] the corresponding place where these thought processes and these perceptions happen? Or are you just observing behavior or are you doing both? Speaker 4: Well, hopefully both. So I'm currently designing a project, which is hopefully gonna do exactly what you just said. Our tools at the moment are very limited, especially because we want to be as noninvasive as possible. Animals don't react in captivity the way that they react in the wild. And obviously they don't have the same space or social structure to be able to do the same sorts of things. [00:08:30] There is an up and coming technology that I hope to apply to this sort of research which would allow biological data to be recorded in real time and it would be completely noninvasive. It would be almost like a sticker, so there'd be no puncturing. There would be no need for captivity. Hopefully we could even apply it with minimal stress to the animal and with that we could have gps data body, we could potentially record the vibrations from their echolocation [00:09:00] and also neurological data and this would be the first information of its kind to be able to correlate if there's an approach or an affiliative behavior between two individuals, what areas of their brain are actually being, you know, lit up and that could really profoundly affect what we know about their structure. Speaker 4: Yeah, that that is sounds really exciting. So it would be noninvasive. Do you know how that works? That must be really amazing. The technology that I'm, I'm hoping to work with [00:09:30] is a flexible microchip and I'm hoping to be working with some of the innovators to make it appliable to dolphins and something that would stick for up to a month. They should scan very quickly, so that is a restraint. I don't know as much of the engineering side of it because I'm not as much tech, but from my conversations with the people developing it, it seems like it might not be up to use for a year or two, but hopefully eventually we'll get [00:10:00] there and we'll have a better understanding of how one of the smartest animals on the planet. Thanks. Are other people currently doing anything more invasive? Captivity can be a very invasive process. How animals and captivity get in captivity are often from Dolphin Slaughters, which kill hundreds of their fellow pod mates to get a handful of dolphins because a live dolphin that is pristine, [00:10:30] you know mark free that goes into entertainment or goes into a laboratory studies. They get taken out and they get sold for hundreds of thousands of dollars and the rest of them get slaughtered and sold into the meat markets. Speaker 6: Mm MM. Speaker 3: You are listening to spectrum on k a l x Berkeley. Our guest today is Tony Bow-tie Hickerson. Tony is a zoologist. In the next segment she talks about diagnosing Alzheimer's disease. Speaker 4: [00:11:00] I actually wanted to ask you a little bit about the work you're doing with Alzheimer's and dice diagnostic work. Could you maybe tell us a little bit about how the process of diagnosing Alzheimer's works currently and what you're hoping to change about that? Well, there really isn't much in terms of diagnosis that's out for the general public. What I'm actually attempting to do, and initially it was for my own curiosity and you know obviously see the potential for other people to use it as [00:11:30] well. I wanted to test myself on this gene. So there is a gene called apoe e and there are three expressions of it and they account for about 95% of all Hymers, one of these types of accounts for 50% of all hammers. I can essentially locate this gene snippet out of the enormous strand of DNA and then look at their two spots where [00:12:00] the nucleotide is a certain sequence that I can tell you. Speaker 4: If that is type one, two or three of that apathy and off of that, they're very strong statistics that will tell you that you have a very high likelihood or very low likelihood of getting Alzheimer's by a certain age. And it's sort of a spectrum due to the fact that we're deployed. So we have two copies of this gene. So if you have this like really strong negative version and one positive version, you will [00:12:30] have later onset Ohio Hymers. Then if you have two really negative versions, but there are really strong numbers that tell us what your likelihood is. But what I would like to do is to make it something that's very accessible for everyone. I don't want to produce this and market it as some expensive tests that's going to just perpetuate this whole medical debt system. I want this to be something that people can access and know for themselves to be able to plan [00:13:00] for their own future and to be able to take care of themselves and their family members more effectively and responsibly. Speaker 4: So it's pretty similar to the aggressive cancer testing would you say? Or? Um, yeah, it's fairly similar. I haven't looked exactly at that one to see. I believe it is also a snip, which is like this single nucleotide change. So it should be very similar. Do you want to tell us a little bit about the process of you sort of isolating this gene? Did you go through and read the papers [00:13:30] and see that this gene was associated with it and develop the processes snippet on your own or I'm in the process of developing the process to snippet. So right now I'm troubleshooting the primer. So the, the molecule that you use to actually cut the DNA, what I have is currently binding to itself. So it is also binding to the site that I want it to, but it's also binding to itself. So I'm trying to sort that issue out. Speaker 4: It's a process that needs to be critiqued a bit before. I'm willing to, you know, expose more [00:14:00] people to the answers cause I want to make sure that it is very accurate before I would to give someone those sorts of answers. You're currently doing some form of genetic screening and you previously did all of these behavioral studies. It's quite a transition. So how, how did you make that transition? Well they're both in principle based on cognition, mental abilities and so all Hymers is the degradation of cognitive abilities, the degradation of being able to recall information as well as [00:14:30] the breakdown of even motor skills and language skills and so that is profoundly interesting to me to to understand where and how cognitive abilities act and then to understand how they're dismantled is the cycle of, of the process of understanding exactly how things work. A lot of times we figure out what parts of the brain do what based on lesion studies, which is causing and disruption. Speaker 4: The initial draw [00:15:00] to this was for my own curiosity. And that was sparked because my father has severe dementia. So I wanted to know for him, is this all Hymers or is it something environmental? And so I want to develop a test for him, for myself and for the public to know what's their likelihood so that they can plan for the future. Are there other differentiating factors you could look at as well besides this, besides this gene? So the gene is pretty profound and [00:15:30] it's significance in whether or not people get all hammers. But there's, there's also, you know, of course a lot of different factors and I should mention that like echoey is a specific kind of all hammers. It's not early onset and not all dementia is Alzheimer's. There's lots of ways to get dementia in old age. So this isn't like a yes, no test. Speaker 4: If you have a really great diagnostic and it looks like you're clear for this, it doesn't mean that when you hit 80 that you're not gonna have problems [00:16:00] still. You still have to take care of yourself. And a lot of studies have shown that simple things and everyone says this, but simple things like diet and exercise. If you exercise on a regular basis, you can break down a lot of these corrosive molecules that cause a lot of mental problems, cause a lot of cardiovascular problems and you have to keep your metabolism up to deal with this and your body will also, you know, work to heal itself. It's just really profound what control you have over your future. [00:16:30] Like I don't want to give people this test and say you're doing, I feel that you two have a lot more control than a lot of people want to admit over the future. And so take responsibility for yourself and take care of your body. Go exercise and eat well and have lots of friends and learn new languages and go travel. See the world Speaker 2: spectrum is a science and technology show on KALX Berkeley. Our guest [00:17:00] today is Tony Bodhi Hickerson in the next segment that Tony talks about, the new Berkeley Bio lab. Speaker 4: So you're involved in a biohacker space. Uh, yes. So actually as of last weekend we moved into a space in Valeho which is my n when the other core members lab on the, hopefully we will be also opening a space [00:17:30] in Berkeley eventually, but for now we're in relay hope and it's essentially like a hacker space, but it's in biotech in general and you pay a membership and you have access to the lab and the materials to do your own research, detached from corporate biases and the strains of academia. So we provide a space in the community to kind of teach each other and [00:18:00] to work in and we allow real hard science to take place and sort of a pioneer setting. What's the name of it and how does it compare it to bio curious and some of the other spaces in the bay area? Speaker 4: Sure. The name of the lab is going to be Berkeley bio labs. Some of the other entities that will be occurring within this lab is a June cell technologies. We're trying to be much more accessible in that our membership [00:18:30] is only going to be $100 a month, whereas a lot of other bio spaces are $2,000 and up a month. I think that having more spaces isn't necessarily a bad thing. We tend to be a little bit more focused on regenerative medicine and stem cell research, so people who are more focused along that lines might be more attracted to work with us, but certainly weren't. We're not discriminating against people who aren't in stem cell research or regenerative medicine. That's just what we tend to do. I shouldn't ask you if you could [00:19:00] tell us a little bit more about the projects that are happening in the space now. Speaker 4: At the moment, we haven't even opened up yet. We were literally still moving all of the giant centrifuges and automated robots. And so right now I'm is my project as well as John's London, which is one of the founding members of the biohacker lab and he works in regenerative medicine and stem cells. [00:19:30] And once we kind of get settled and open our doors, we'll hopefully be screening lots of potential innovators to come and join our project and not necessarily his project but you know, whatever inspires them to try and you know, make a difference. And what will that screening process look like? It'll honestly be very personal. We're going to just meet with people one on one and see what they're interested in doing, what they have done and what they want to see in the future. It's much more about the people and [00:20:00] their drive to do something than the letters after their name. Speaker 4: We all feel that someone who's really driven to take the four or five years after a bachelor's and do their own research potentially has a lot more to offer than someone who might not know what they want to do in his just signing up for pastry. Cause they feel like it's the next step. So we're definitely open to pioneers, innovators and people who are willing to scrap to make a change. How are you getting the word out about the a space? [00:20:30] Well, actually the, the first thing that has happened so far on the 24th I believe it was, we had a paper written about us in nature. And so that was the first real publicity, and this is the second. So the article was called biotechnology independent streak. If anyone cares to look it up in the July 24th issue, it's gotta be super expensive to have all of the high mated robots and the giant centrifuge. Speaker 4: How are you financing [00:21:00] the space? All of the equipment is already owned by John. He's been working in biotech for quite some time and it has accumulated a very impressive stock of machinery and equipment and he's more than happy to share, to enable other people. He's been really phenomenal and assisting me and getting into a lab space, she's really enabled me to be able to do research that I would never be able to do on my own. And he's doing that for hopefully a lot of other people and so [00:21:30] I would hope to perpetuate that and help people get into it and start making a difference. What do you anticipate the future of the hackerspace pain? Well, we hope that we find lots of driven people who want to come and we are overflowing with scientists until we need to open up another space. I would love to see this be a scientific movement. Speaker 4: Science is all about curiosity. It's about having a question and figuring out how to find the answer and I think that that's [00:22:00] something in our education system that a lot of times is not really taught. People are taught facts, they're not taught. How do you figure facts out? You know? It's not about memorization. It's about teaching yourself how to think. How did you get into science? I have always been profoundly curious, but actually I started out as an art major and about two and a half years in I got called into my advisor's [00:22:30] office and I said, you can't take any more science classes. Told me you filled up all your electives and another semester. And if you take another science class, then we're going to kick you out of the fine arts school. So I said, okay. And I put in an application at another university and switched into science because I thought it was completely absurd that they would hinder me from taking science classes, but it was just a curiosity to understand how [00:23:00] the molecular and biological world works. Understand, you know, how life happens and how stars are born. It's something that I don't understand why every single person doesn't have this profound emotional response to understanding all Tony, thanks for joining. Yes, thank you. Speaker 2: Oh, [inaudible]. If you can not always catch spectrum broadcasts, know that shows are archived [00:23:30] on iTunes university, we have created a simple link to the archive just for you. The link is tiny url.com/calyx spectrum. No, a few of the science and technology events happening locally over the next two weeks. Rick Karnofsky and I present the calendar. Speaker 3: Tuesday. August 27th the UC Berkeley Botanical Gardens [00:24:00] will host a guided butterfly walk. Join Sally Levinson, the gardens resident caterpillar lady on a walk through the amazing collections of the botanical garden in search of butterflies to register for a butterfly walk, which is free with admission email garden@berkeley.edu the butterfly walk will be held from three to 4:00 PM on Tuesday, August 27th at the UC Berkeley Botanical Gardens. At this month, [00:24:30] actual science, you can learn how the properties of diamonds are uniquely suited for scientific research. Christine beavers is a research scientist based at the advanced light source at Lawrence Berkeley National Lab. Her specialty is crystallography, which is the determination of 3d structures of molecules from crystals using x-rays. Actual science will be on Thursday, August 29th at 6:00 PM [00:25:00] at actual cafe six three three four San Pablo Avenue in Oakland and mission is free. UC Berkeley is holding its first monthly blood drive of the school year on August 29th you can make an appointment online, but walk-ins are also welcome. Speaker 3: You are eligible to donate if you are in good health way, at least 110 pounds and are 17 years or older. The blood drive will be on Thursday, August 29th in the Anna had [00:25:30] alumni house on the UC Berkeley campus. It will last from 9:00 AM to 3:00 PM you can make an appointment or find more information at the website. Red cross.org using the sponsor code you see be wonder fest and ask a scientist present the neuroscience of magic on Wednesday, September 4th at the [inaudible] street food park, 48 [00:26:00] 11th street in San Francisco. You CSF professor of neuroscience, Adam Gazzaley and the comedy magician, Robert Strong. We'll lead discussions from ancient conjurers t quick handed con artists, two big ticket Las Vegas illusionists magicians. Throughout the ages, I've been expertly manipulating human at attention and perception to dazzle and delight us. [00:26:30] Of course, you know that the phenomenon of cognitive and sensory illusions are responsible for the magic, but you've got to admit it still kind of freaks you out when some guy in a top hat defies the of nature right in front of your eyes. The event is free. Now, two news stories. Speaker 3: Berkeley News Center reports a new theory by fluid dynamics experts at the University of California Berkeley shows how Zombie vorticies [00:27:00] help lead to the birth of a new star reporting in the journal Physical Review Letters, a team led by computational physicist Philip Marcus shows how variations in gas density led to instability, which generates the whirlpool like vorticies needed for stars to form. The Zombie reference is an astronomical nod to pop culture and because of the so called dead zones in which these vorticies exist, this new model has caught the [00:27:30] attention of Marcus's colleagues at UC Berkeley, including Richard Klein, adjunct professor of astronomy and fellow star formation expert, Christopher McKee, UC Berkeley professor of physics and astronomy. They were not part of the work described in physical review letters but are collaborating with Marcus to put the Zombie vorticies through more tests. Science daily reports the identification of what may be the earliest known [00:28:00] biomarker associated with the risk of developing Alzheimer's disease. Speaker 3: The results suggest that this novel potential biomarker is present in cerebral spinal fluid at least a decade before signs of dementia manifest. If our initial findings can be replicated by other laboratories, the results will change the way we currently think about the causes of Alzheimer's Disease said Dr Ramon true? Yes. Research professor [00:28:30] at the CSIC Institute of Biomedical Research of Barcelona and lead author of the study that was published in annals of neurology. This discovery may enable us to search for more effective treatments that can be administered during the preclinical stage. These C S I c researchers demonstrated that a decrease in the content of micro chondrial DNA in cerebral spinal fluid may be a preclinical indicator [00:29:00] for Alzheimer's disease. Furthermore, there may be a direct causal relationship Speaker 6: [inaudible].Speaker 1: The music hub during this show was written and produced by Alex Simon. Thank you for listening to spectrum. If you have comments about the show, please send them to us via email. Address [00:29:30] is spectrum dot k. Alright. yahoo.com join us in two weeks at this same time. [inaudible]. Hosted on Acast. See acast.com/privacy for more information.

It can be found almost everywhere, and most of it won’t harm you. But when it’s found in an apartment, it means water has leaked into the building or is coming from somewhere inside. Who is responsible for the clean-up? On today's episode of Legal Talk, attorneys Marc Schneider, partner in Schneider Mitola, and Richard Klein, a solo practitioner in Manhattan, discuss the many issues that mold causes.

John Plunkett and guests discuss the Review Show as it moves to BBC4, and ponder the future of the music industry

Smoking is fast becoming outré in New York’s public spaces, and apartment buildings are getting in on the act as well. Concerned about the health effects of second-hand smoke, co-op and condo boards have begun taking steps to eradicate cigarette smoking from common areas and even private apartments. But this is a new trend and in many ways uncharted territory for boards. What’s the most effective way to put a ban on smoking in your building? That’s the question posed to our attorney panel this week. Can the ban apply to some residents while grandfathering other smokers in? How do you make sure the ban will stand up in court? And, perhaps most importantly, how do you enforce it? The laws on this subject are different for co-ops versus condos, and our attorney panel separates out the various strands of legal thought and opinion to bring you the clear truth. On the panel this week, Habitat Publisher and Editor-in-Chief Carol J. Ott talks with John J. LaGumina of The LaGumina Law Firm and Richard Klein of the Law Offices of Richard Klein. Music: Stevie’s Amp Shack, “Blues Shuffle in A One Take Improv Exercise” http://freemusicarchive.org/music/Stevies_Amp_Shack/~/Blues_Shuffle_in_A_One_Take_Improv_Exercise

On the first HWYW episode of spring, CBS Sunday Morning correspondent, humorist, author and brilliant expert on many important things including musical theater, MO ROCCA is here to discuss what you should and shouldn't say to celebrities that are famous for one thing, why Gypsy is the best musical, what kind of woman Mo looks like when he's in drag, and what Jerry Herman score he listened to on his Discman when he was jogging in Tokyo.  Then, DAVE CULLEN, author of the book Columbine, is here to talk to Julie about what we've established is one of the greatest non-fiction books published in a long time. It is an important conversation about a riveting book that will hopefully be more fascinating to you than it will just merely give you nightmares. Plus, Julie expresses: -Relief that a second season of Smash will exist -Disappointment in the New York Times for publishing an extensive essay about a gel manicure that indirectly references Nora Ephron -Indifference around the latest Burton-Depp collaboration that doesn't seem to be hurting anybody -And delight that Sean Young has been appearing in public wearing a neck brace. Also! What not to say to Richard Klein! A contest having to do with the March 29th live show in LA! And the enormity and scope of Jonah Hill's torso. A compelling and occasionally intense show, after what was not a great week, at least for me. I hope you love it!  

Dr. McKee's research focuses on the theory of physical processes in the interstellar medium, the diffuse gas between the stars. How do stars form out of this tenuous gas, and what effect do the stars have back on the interstellar medium? Jerry Ostriker and I developed the three-phase model of the interstellar medium, which has been widely used to organize and interpret observations of the diffuse interstellar medium. With my colleagues and students, I have worked on the theory of the evaporation of clouds by both hot gas and ionizing radiation, the evolution of supernova remnants and stellar wind bubbles, the structure and emission spectrum of interstellar shocks, the evolution of interstellar dust grains, the structure of molecular clouds, and on the theory of active galactic nuclei, particularly the study of reverberation mapping and of Compton-heated coronae and winds above accretion disks. I am currently concentrating on the theory of star formation, including the formation of the first stars. My students and I use both analytic and numerical techniques to address these problems. Richard Klein and I have established the Berkeley Astrophysical Fluid Dynamics Group to develop the technique of adaptive mesh refinement for numerical simulations of astrophysical fluid dynamics, particularly star formation.

This week the BBC Trust, while broadly praising BBC 4, has said the channel needs to make a bigger impact on the majority of viewers who do not watch it. The trust made similar comments about 6 Music earlier this year, before the BBC announced plans to close that radio station. Does controller Richard Klein have any fears for BBC 4's future? There are claims that media reports of allegations of corruption at Fifa may harm England's bid to host the 2018 World Cup. One suggestion is that journalists should put their findings to Fifa's ethics committee rather than publish. The claims follow reports from the Sunday Times Insight team last month and ahead of a BBC Panorama report expected later this month. Richard Caborn, former minister and ambassador for the bid, discusses this with Andrew Hogg, formerly editor of Insight.And why are Ann Widdecombe and Wagner so popular with Strictly Come Dancing and X Factor audiences, when the judges say their performances are technically so much weaker than their competitors? What role to the judges play in raising their popularity? Emma Cox of The Sun and The Telegraph's Neil Midgley discuss.The producer is Simon Tillotson.

Richard Klein served as editor for the PNAS Special Feature titled "Out of Africa". This collection of articles explores the historical expansion of Homo sapiens from Africa to Eurasia. The Special Feature, along with an editorial by Dr. Klein, will publish in the September 22 issue of PNAS.