Podcasts about cardiac transplantation

Host: Darryl S. Chutka, M.D. Guest: Ruben J. Crespo-Diaz, M.D., Ph.D. The world's first human-to-human heart transplant was performed in 1967 and represented a significant breakthrough for medical science. Although the transplant patient only survived 18 days, it was still a historic event. Since this initial heart transplant, significant improvements have been made in the field of organ transplantation and currently, approximately 5000 heart transplants are performed annually. Unfortunately, over ten times this number could benefit from the procedure. What's the limiting factor in the number of heart transplants performed? What are the current criteria of eligibility for a heart transplant? What are some of the improvements in the field of cardiac transplant surgery? I'll get answers to these questions and more from my guest, Ruben J. Crespo-Diaz, M.D., Ph.D., from the Department of Cardiovascular Medicine at the Mayo Clinic. The topic for this podcast is “Cardiac Transplant”. Learn more about this Transplant Series:  Mayo Clinic Talks: Donate Life: Transplantation Series | Mayo Clinic School of Continuous Professional Development Connect with Mayo Clinic's Transplant Center online at https://mayoclinic.org/transplant or on X @MayoTransplant. To learn more and register to be an organ donor please visit https://careinfo.mayoclinic.org/organ-donation. Connect and listen with Mayo Clinic Podcasts | Mayo Clinic School of Continuous Professional Development

In this podcast episode, Dr. Diego Delgado discusses how to manage patients with mixed phenotype hereditary transthyretin amyloidosis over the course of their disease from initial symptoms and clinical suspicion, to monitoring patients on treatment. For additional details, please see the related video publication by Dr. Delgado and colleagues: https://www.sciencedirect.com/science/article/pii/S2589790X25001180Our Guest: Dr. Diego Delgado is the Director of the Cardiac Amyloid Centre and Associate Professor in the Division of Cardiology and Cardiac Transplantation at the University Health Network in Toronto, Ontario. Dr. Diego Delgado graduated in Medicine from the Universidad del Salvador in Buenos Aires, Argentina. He completed his Internal Medicine and Cardiology training in Hospital Espanol in Buenos Aires. Subsequently he completed a research fellowship in cardiac transplantation at Rush Presbyterian St Luke's Medical Center in Chicago, US and a research/clinical fellowship in heart failure and transplantation at the Toronto General Hospital.Dr. Delgado completed his Maters of Science in Clinical Epidemiology at the University of Toronto and the Leadership Development Program at Rotman School of Management in Toronto. He is the author of more than 100 publications in the area of heart failure, transplantation and mechanical assist devices. His interests are immunologic aspects of heart failure and transplantation and cardio oncology.This podcast episode was sponsored by AstraZeneca Canada. For other medical education content, please subscribe to our podcast or visit our website at: https://www.impactmedicom.com (https://www.impactmedicom.com/).

Returning for a second study this month, the JHLT Digital Media Editors invite lead author Oliver J.F. Weiner, to discuss the paper, “Sympathetic reinnervation in cardiac transplant recipients: Prevalence, time course, and association with long-term survival.” Dr. Weiner is currently an out of training registrar at Monash Health in Melbourne, Australia, but will soon return to his home of the UK to begin internal medicine training with the intention becoming a cardiologist. He is especially interested in advanced heart failure and electrophysiology. The episode explores: The uncertainty around clinical influences on reinnervation The importance of this single-center study in expanding the literature Potential future treatment options   For the latest studies from JHLT, visit www.jhltonline.org/current, or, if you're an ISHLT member, access your Journal membership at www.ishlt.org/jhlt. Those on lung transplant teams should check the previous episode for a study on recent trends and post-transplant outcomes from EVLP. Don't already get the Journal and want to read along? Join the International Society of Heart and Lung Transplantation at www.ishlt.org for a free subscription, or subscribe today at www.jhltonline.org.

On this episode of JHLT: The Podcast, the Digital Media Editors discuss a new guidelines document from the ISHLT entitled “The 2024 ISHLT Guidelines for the Evaluation and Care of Cardiac Transplant Candidates.” The lead co-authors of the document—Yael Peled, MD, and Anique Ducharme, MD, MSc—are on the podcast to discuss the document. You'll hear about: Challenges in drafting such an overarching document Highlights for clinicians Major changes in the document since the last version How changes in durable and temporary MCS affect use of the document For the latest studies from JHLT, visit www.jhltonline.org/current, or, if you're an ISHLT member, access your Journal membership at www.ishlt.org/jhlt. Join us again later this month for a study on age matching in lung transplantation. Don't already get the Journal and want to read along? Join the International Society of Heart and Lung Transplantation at www.ishlt.org for a free subscription, or subscribe today at www.jhltonline.org.

On this episode of JHLT: The Podcast, the JHLT Digital Media Editors explore two studies from the July issue of The Journal of Heart and Lung Transplantation. Digital Media Editor Marty Tam, MD, a transplant cardiologist from the University of Michigan in Ann Arbor, hosts this episode.   First, Dr. Tam and Digital Media Editor Erika Lease, MD, FCCP, interview their first guest, Daniel Calabrese, MD, first author on the study “Macrophage and CD8 T cell discordance are associated with acute lung allograft dysfunction progression.” The study's authors sought to tackle challenges behind early detection of chronic lung allograft dysfunction (CLAD) by identifying biomarkers associated with acute lung allograft dysfunction (ALAD) progression to CLAD.   To do this, they collected bronchoalveolar lavage (BAL) cells at the time of ALAD diagnosis and performed single cell RNA sequencing to identify significant differences in 26 unique cell populations across groups, with discordant CD8 T cells and macrophages providing the best discrimination between ALAD with decline from ALAD with recovery and controls.   Dr. Calabrese discusses how his team identified the diagnostic criteria, why the biomarkers might lead ALAD to progress to CLAD, and how the findings might lead to early targeted therapies.   Next, Dr. Tam joins and Digital Media Editor Khue Ton, MD and David Schibilsky, MD, to interview their next guest, David D'Alessandro, MD, the Surgical Director of Cardiac Transplantation and MCS at Massachusetts General Hospital in Boston. Dr. D'Alessandro was the first author on the study “Impact of controlled hypothermic preservation on outcomes following heart transplantation,” which sought to assess the impact of the Paragonix SherpaPak Cardiac Transport System, a device allowing controlled hypothermic  preservation, on rates of primary graft dysfunction (PGD) and post-transplant mortality.   The key finding was that controlled hypothermic preservation was associated with a lower incidence of severe PGD – 6.6% compared to ice storage at 10.4%. In the conversation, Dr. D'Alessandro answers questions about the need for innovation over traditional ice cold storage, the greatest advantages of controlled hypothermic approaches, and the next steps in this research.   Follow along at www.jhltonline.org/current, or, if you're an ISHLT member, access your Journal membership at www.ishlt.org/jhlt.   Don't already get the Journal and want to read along? Join the International Society of Heart and Lung Transplantation at www.ishlt.org for a free subscription, or subscribe today at www.jhltonline.org.

Tanner Melton, PharmD reviews pharmacologic management of post cardiac transplant. For more pharmacy content, follow Mayo Clinic Pharmacy Residency Programs @MayoPharmRes. You can also connect with the Mayo Clinic's School of Continuous Professional Development online at https://ce.mayo.edu/ or on Twitter @MayoMedEd. 

Commentary by Dr. Valentin Fuster

Heart failure impacts more than 8 million people in the United States today, but with the right treatments, the course of the disease can be corrected. Dr. Nir Uriel is determined to do just that. He's spent his career pushing forward advancements to better diagnose and treat advanced heart failure patients. These advancements include a new, magnetic levitated pump that can improve the outcomes of patients denied transplantation due to their age or severity of disease, as well as breakthrough testing that analyzes cell-free DNA to detect transplant rejection, changing the course of immunosuppressive therapy. Dr. Uriel is also pioneering the use of technology to remotely monitor heart failure patients, and diagnose heart failure before symptoms even occur. In this episode, Dr. Uriel details his multifaceted methods to treating heart failure, the value of a team approach, and the importance of empathetic, patient-centered care.

There is increased recognition of the right ventricle's pivotal role in health and disease. In this episode, we will discuss Right Ventricular Failure in the context of critical illness. Our guest is Dr. Ryan Tedford, a practicing cardiologist focusing on heart failure. Dr. Tedford is the Dr. Peter C. Gaze Endowed Chair in Heart Failure. He is a Professor of Medicine and Cardiology, Section Chief for Heart Failure, Medical Director of Cardiac Transplantation, and Director of the Advanced Heart Failure & Transplant Fellowship Training Program at the Medical University of South Carolina. Additional Resources Right Ventricular Failure. Houston B, Britain EL, and Tedford R. N Engl J of Med 2023: https://pubmed.ncbi.nlm.nih.gov/36947468/ Diuretic versus placebo in intermediate-risk acute pulmonary embolism: a randomized clinical trial. Lim P, et al. Eur Heart J Acute Cardiovasc Care 2022: https://pubmed.ncbi.nlm.nih.gov/34632490/ Multimodality Imaging of Right Heart Function. Hahn R, et al. JACC 2023: https://pubmed.ncbi.nlm.nih.gov/37164529/ Ventricular dilation is associated with improved cardiovascular performance and survival in sepsis. Zanotti, s et al. CHEST 2010: https://pubmed.ncbi.nlm.nih.gov/20651022/ Link to recent podcast on Acute Pulmonary Embolism: https://soundphysicians.com/podcast-episode/?podcast_id=342&track_id=1463000353 Books Mentioned in this Episode: The Right Ventricle in Health and Disease. N Voelkel and D Schranz, Editors: https://bit.ly/436iROd The Code Breaker: Jennifer Doudna, Gene Editing, and the Future of the Human Race. By W Isaacson: https://bit.ly/3IDUL5a

It's another session of CardioNerds Rounds! In these rounds, Co-Chair, Dr. Karan Desai (previous FIT at the University of Maryland Medical Center, and now faculty at Johns Hopkins) joins Dr. Ryan Tedford (Professor of Medicine and Chief of Heart Failure and Medical Directory of Cardiac Transplantation at the Medical University of South Carolina in Charleston, SC) to discuss the nuances of managing pulmonary hypertension in the setting of left-sided heart disease. Dr. Tedford is an internationally-recognized clinical researcher, educator, clinician and mentor, with research focuses that include the hemodynamic assessment of the right ventricle and its interaction with the pulmonary circulation and left heart. This episode is supported with unrestricted funding from Zoll LifeVest. A special thank you to Mitzy Applegate and Ivan Chevere for their production skills that help make CardioNerds Rounds such an amazing success. All CardioNerds content is planned, produced, and reviewed solely by CardioNerds. Case details are altered to protect patient health information. CardioNerds Rounds is co-chaired by Dr. Karan Desai and Dr. Natalie Stokes.  Speaker disclosures: None Cases discussed and Show Notes • References • Production Team CardioNerds Rounds PageCardioNerds Episode PageCardioNerds AcademyCardionerds Healy Honor Roll CardioNerds Journal ClubSubscribe to The Heartbeat Newsletter!Check out CardioNerds SWAG!Become a CardioNerds Patron! Show notes - Challenging Cases - Nuances in Pulmonary Hypertension Management with Dr. Ryan Tedford Case #1 Synopsis: A woman in her late 30s presented to the hospital with 4 weeks of worsening dyspnea. Her history includes dilated non-ischemic cardiomyopathy diagnosed in the setting of a VT arrest around 10 years prior. Over the past 10 years she has been on guideline-directed medical therapy with symptoms that had been relatively controlled (characterized as NYHA Class II), but without objective improvement in her LV dimensions or ejection fraction (LVEF 15-20% by TTE and CMR and LVIDd at 6.8 cm). Over the past few months she had been noting decreased exercise tolerance, worsening orthopnea, and episodes of symptomatic hypotension at home. When she arrived to the hospital, she presented with BP 95/70 mmHg, increased respiratory effort, congestion and an overall profile consistent with SCAI Stage C-HF shock. In the case, we go through the hemodynamics at various points during her hospitalization and discuss options for management including medical therapy and mechanical support. The patient was eventually bridged to transplant with an Impella 5.5. Initial Hemodynamics Right Atrium (RA) Pressure Tracing: Right Ventricle (RV) Pressure Tracing: Pulmonary Artery (PA) Pressure Tracing: Pulmonary Capillary Wedge Pressure (PCWP) Tracing: Case 1 Rounding Pearls One of the first points that Dr. Tedford made was thinking about our classic frameworks of characterizing acute decompensated heart failure, specifically the “Stevenson” classification developed by Dr. Lynne Stevenson that phenotypes patients along two axes: congestion (wet or dry) and perfusion (warm or cold). Dr. Tedford cautioned that young patients may not fit into these classic boxes well, and that a normal lactate should not re-assure the clinician that perfusion is normal.In reviewing the waveforms, Dr. Tedford took a moment to note that besides just recording the absolute values of the pressures transduced in each chamber or vessel, it is critical to understand the morphology of the tracings themselves. For instance, with the RA pressure tracing above, there is no respiratory variation in the mean pressure. This is essentially a “resting Kussmaul's sign,” which is typically indicative of significant RV dysfunction. Thus, even though our echocardiogram in this case did not necessarily show a significantly dilated RV with mildly reduced longitudinal function (T...

This week we delve into the world of heart transplantation to review a recent article on the topic of outcomes of the Down syndrome patient undergoing heart transplantation. Are infections or cancers more common in this patient group following transplantation? What role does intellectual disability play in the present era in decisions regarding transplantation in this patient group? Associate Professor of Pediatrics at Vanderbilt University, Dr. Justin Godown, shares his insights into this important topic. doi: 10.1161/JAHA.121.024883

Dr. Douglas Horstmanshof is Co-Director of INTEGRIS Advanced Cardiac Care and the program director of the Heart Failure Institute (HFI) at INTEGRIS Baptist Medical Center in Oklahoma City. “Dr. Doug” came to Oklahoma in 2005 to serve patients suffering from advanced heart failure with a complete array of services, including personalized medical management, heart transplantation, and left ventricular assist devices.   Dr. Doug was raised in Michigan and earned his undergraduate degree at Calvin College in Grand Rapids, Michigan. He attended medical school at Northwestern University School of Medicine in Chicago, Illinois, and was elected to the Alpha Omega Alpha medical honor society while there. Subsequently, he completed an internship and residency in Internal Medicine, followed by a fellowship in Cardiovascular Disease at Washington University in St. Louis / Barnes-Jewish Hospital. He also served as Chief Resident for the internal medicine training program, providing administrative and educational oversight to approximately 150 medical residents. He received advanced training as the Hawes Fellow in Heart Failure and Cardiac Transplantation at Washington University, which was followed up by a faculty appointment there until moving to Oklahoma.  He is board-certified in both Cardiovascular Disease and Advanced Heart Failure and Cardiac Transplantation by the American Board of Internal Medicine.   As Co-Director of the Advanced Cardiac Care team at INTEGRIS Nazih Zuhdi Transplant Institute (NZTI), Dr. Doug has always focused on individualized patient care with a human touch while utilizing the most advanced heart therapies available in the state of Oklahoma. He and the IACC team have made important contributions to research in the field of advanced heart failure, with publication in multiple journals, including the New England Journal of Medicine. He is also an internationally active educator and speaker with a passion for educating health care providers and patients about heart failure and mechanical circulatory support. Dr. Doug is married to his college sweetheart and has three children. Welcome to Action City, Dr. Doug! 

In this episode, Dr. Gary Sherman has a most informative discussion about heart failure with one of the foremost experts on heart failure in the country, Dr. Nandini Nair. Dr. Nair earned her Ph.D. in biochemistry at the Indian Institute of Science, in Bangalore, India.  She earned her medical degree in 2000, at George's University School of Medicine, Grenada, WI.  Dr. Nair then came to the United States to Drexel University College of Medicine, in Philadelphia, PA,  for her Residency in Internal Medicine during the years 2000-2003.  In 2007-2008, she completed a fellowship in Advanced Heart Failure and Transplant Cardiology at Stanford University School of Medicine, Palo Alto, in California. It was then, that Dr. Nair went onto Brown University School of Medicine, in Providence, RI, and earned her EMHL (Exec. Masters in Healthcare Leadership) during the years 2019-21. Now- has completed 14 years post-fellowship experience as Medical Director of Advanced Heart Failure, Mechanical Circulatory Support, and Cardiac Transplantation.Wow!! We are so privileged to be able to learn from Dr. Nair's vast education and experience. Do not miss this intriguing episode! 

Surgical and interventional options such as surgical myectomy or alcohol septal ablation may help those with obstructive Hypertrophic Cardiomyopathy (HCM) to reduce or remove the obstruction. A similar option is unavailable to those with non-obstructive HCM.  Heart transplants are considered as a last resort for HCM patients who progress to end stages of the disease.  Learn more about advanced surgical approaches and emerging medical therapies for HCM.

What happens when a Fontan patient needs a tune-up? What kinds of procedures might a Fontan patient need after living with a Fontan heart? What can we learn from an experienced Fontanner who might be facing multiple medical procedures?Leslie Castro is a 48-year-old former single ventricle patient from Pennsylvania. She was born with tricuspid atresia, pulmonary stenosis and multiple other heart defects, and had the Classic Fontan at the age of 12 in 1985. She is almost 2 years post-transplant. Prior to transplant, Leslie had a very complicated journey with her heart. In just one day, she underwent a Fontan revision, Cox-Maze procedure, and pacemaker implantation. She also experienced arrhythmias and tried a range of medications to control her symptoms. Ultimately, the Fontan revision was unsuccessful which led to her receiving a transplant from a Hepatitis C positive intravenous drug user.   Fortunately, today Leslie is doing well and she is here to talk to us about her journey to transplant. Links to Leslie's other “Heart to Heart with Anna” appearances:Classic Fontan Survivor Post-Cardiac Transplant: https://www.buzzsprout.com/62761/7884964Hepatitis C and Cardiac Transplantation:  https://www.buzzsprout.com/62761/8500544An article by Dr. Barbara Deal, Dr. Constantine Mavroudis, and Dr. Carl Backer regarding their experience with Fontan revisions: https://academic.oup.com/ejcts/article/34/5/1034/379177?login=trueAnna's Buzzsprout Affiliate Link (if you'd like to try Buzzsprout for your podcast and get a bonus gift card -- and Anna will, too!) use this link: https://www.buzzsprout.com/?referrer_id=16817Links to 'Heart to Heart with Anna' Social Media and Podcast Pages:Apple Podcasts: https://itunes.apple.com/us/podcast/heart-to-heart-with-anna/id1132261435?mt=2MeWe: https://mewe.com/i/annajaworskiFacebook: https://www.facebook.com/HearttoHeartwithAnna/Instagram: https://www.instagram.com/hearttoheartwithanna/Twitter: https://twitter.com/AnnaJaworskiYouTube: https://www.youtube.com/channel/UCGPKwIU5M_YOxvtWepFR5ZwWebsite: https://www.hug-podcastnetwork.com/Support the show (https://www.patreon.com/HearttoHeart)

Leslie Castro is a 47-year-old former single ventricle patient from Pennsylvania. She was born with tricuspid atresia, pulmonary stenosis, and multiple other heart defects, and had the Classic Fontan at the age of 12 in 1985. Just over a year ago, she received a heart transplant. Her donor was a 29-year-old woman who was a Hepatitis C positive intravenous drug user, and Leslie had to take a case study drug to avoid contracting the virus. Leslie had a very bumpy road to recovery with multiple complications involving her brain, heart, and lungs, and required procedures after the transplant to alleviate a brain bleed and drain fluid from her lungs. This is Leslie’s second appearance on the show. My loyal Listeners may remember Leslie’s other program, “Classic Fontan Survivor Post-Cardiac Transplant!” (https://www.buzzsprout.com/62761/7884964)In this episode, Leslie teaches us about how some heart transplant recipients are now receiving hearts from donors who tested positive for Hepatitis C and what that means for donors and recipients.Anna's Buzzsprout Affiliate Link (if you'd like to try Buzzsprout for your podcast and get a bonus gift card -- and Anna will, too!) use this link: https://www.buzzsprout.com/?referrer_id=16817Links to 'Heart to Heart with Anna' Social Media and Podcast Pages:Apple Podcasts: https://itunes.apple.com/us/podcast/heart-to-heart-with-anna/id1132261435?mt=2MeWe: https://mewe.com/i/annajaworskiFacebook: https://www.facebook.com/HearttoHeartwithAnna/Instagram: https://www.instagram.com/hearttoheartwithanna/Twitter: https://twitter.com/AnnaJaworskiYouTube: https://www.youtube.com/channel/UCGPKwIU5M_YOxvtWepFR5ZwInstagram: https://www.instagram.com/hearttoheartwithanna/ Website: https://www.hug-podcastnetwork.com/If you enjoy this program and would like to be a Patron, please check out our Patreon page: https://www.patreon.com/HeartToHeartSupport the show (https://www.patreon.com/HearttoHeart)

Now available for CME! Follow this link - https://www.surveymonkey.com/r/SW9Q75QEnjoy this podcast featuring Dr. Egolum who has completed two fellowships in Cardiovascular Disease and Advanced Heart Failure, and Mechanical Circulatory Support Devices and Cardiac Transplantation at Vanderbilt University. We hope you enjoy, please send me any feedback at Stephen.Morgan@nghs.comDr. Egolum’s lecture - (it’s apparently 45 pages and not 12)https://docs.google.com/presentation/d/1MvjVZQwQn8CHh8yEf1H0P9neJ7l8YAgpod0REEw8XqY/edit

Professor Stephen Clark, Consultant Cardiac and Transplant Surgeon from the Freeman Hospital in Newcastle, takes us through the fundamentals of Cardiac Transplantation.Contact: SCTSEducationpodcast@gmail.com 

Dr. Kittleson has a heart for hearts! What makes life so exciting for this advanced heart failure and cardiac transplantation specialist and GME program director?

He is the son of Cuban immigrants and had a very humble upbringing. Now he is one of the country's leading heart-transplantation surgeons. He shares his most eye-opening stories, including the emotional side of helping patients with COVID-19, dealing with mental health issues in his own family and more. This is my conversation with the director of Cardiac Transplantation at North Shore University Hospital in Manhasset (NY), Dr. Brian Lima. To purchase Dr. Lima's book titled "Heart To Beat: A Cardiac Surgeon’s Inspiring Story of Success and Overcoming Adversity?The Heart Way" click here: https://amzn.to/2XrcrJ8 Alberto Sardiñas is a TV and radio personality, host of the “Passion Accomplished Podcast" where he listens to inspiring personal stories and looks for great lessons that help everyone live their best life. Alberto has interviewed thousands of people throughout his career and, by asking the right questions, he allows guests to open up and narrate the most difficult chapters of their lives while finding the lessons behind them. With a social media following of close to 2.8 million fans, people all over the world look to Alberto to share and hear amazing stories that inspire them to achieve their dreams. He is based in Miami, Florida. The Passion Accomplished podcast with Alberto Sardiñas is available on: Apple Podcasts: https://apple.co/2ymkwm9 Spotify: https://spoti.fi/2KigK0r TuneIn: http://tun.in/pjmYZ And on the web: https://bit.ly/2V5OcAO #HeartToBeat #DrBrianLima #PassionAccomplished

Kathryn interviews VP of Community & Culture, Zillow Group, and CEO, OwnTrail.com Rebekah Bastian, author of “Blaze Your Own Trail: An Interactive Guide to Navigating Life with Confidence, Solidarity and Compassion.” Through compelling mix-and-match, real-world storylines and provocative data points, Bastian inspires women to embrace the fact that there's no one “perfect” linear path. She's been featured in Medium, HuffPost, Thrive Global and is a regular contributor to Forbes. Kathryn also interviews Director of Cardiac Transplantation, The Sandra Atlas Bass Heart Hospital Dr. Brian Lima, author of “Heart To Beat: A Cardiac Surgeon's Inspiring Story of Success and Overcoming Adversity - The Heart Way.” He shares his story, giving everyone – not just aspiring physicians – the tools needed to be their best selves. Dr. Lima completed his medical training at Duke University and the Cleveland Clinic and published nearly 80 articles in peer-reviewed medical journals.

Kathryn interviews VP of Community & Culture, Zillow Group, and CEO, OwnTrail.com Rebekah Bastian, author of “Blaze Your Own Trail: An Interactive Guide to Navigating Life with Confidence, Solidarity and Compassion.” Through compelling mix-and-match, real-world storylines and provocative data points, Bastian inspires women to embrace the fact that there's no one “perfect” linear path. She's been featured in Medium, HuffPost, Thrive Global and is a regular contributor to Forbes. Kathryn also interviews Director of Cardiac Transplantation, The Sandra Atlas Bass Heart Hospital Dr. Brian Lima, author of “Heart To Beat: A Cardiac Surgeon's Inspiring Story of Success and Overcoming Adversity - The Heart Way.” He shares his story, giving everyone – not just aspiring physicians – the tools needed to be their best selves. Dr. Lima completed his medical training at Duke University and the Cleveland Clinic and published nearly 80 articles in peer-reviewed medical journals.

Kathryn interviews Founder, Non-Obvious Company Rohit Bhargava, WSJ bestselling author of “Non-Obvious Megatrends: How to See What Others Miss and Predict the Future.” You don't need to be a futurist or innovator to learn to think like one. The key to growing your business or propelling your career into the next decade lies in better understanding the present. Bhargava is regularly featured as an expert commentator in global media including Harvard Business Review, The Guardian and NPR. Kathryn also interviews Director of Cardiac Transplantation, The Sandra Atlas Bass Heart Hospital Dr. Brian Lima, author of “Heart To Beat: A Cardiac Surgeon's Inspiring Story of Success and Overcoming Adversity - The Heart Way.” He shares his story, giving everyone – not just aspiring physicians – the tools needed to be their best selves. Dr. Lima completed his medical training at Duke University and the Cleveland Clinic and published nearly 80 articles in peer-reviewed medical journals.

Kathryn interviews Founder, Non-Obvious Company Rohit Bhargava, WSJ bestselling author of “Non-Obvious Megatrends: How to See What Others Miss and Predict the Future.” You don't need to be a futurist or innovator to learn to think like one. The key to growing your business or propelling your career into the next decade lies in better understanding the present. Bhargava is regularly featured as an expert commentator in global media including Harvard Business Review, The Guardian and NPR. Kathryn also interviews Director of Cardiac Transplantation, The Sandra Atlas Bass Heart Hospital Dr. Brian Lima, author of “Heart To Beat: A Cardiac Surgeon's Inspiring Story of Success and Overcoming Adversity - The Heart Way.” He shares his story, giving everyone – not just aspiring physicians – the tools needed to be their best selves. Dr. Lima completed his medical training at Duke University and the Cleveland Clinic and published nearly 80 articles in peer-reviewed medical journals.

Kathryn interviews Founder, Non-Obvious Company Rohit Bhargava, WSJ bestselling author of “Non-Obvious Megatrends: How to See What Others Miss and Predict the Future.” You don't need to be a futurist or innovator to learn to think like one. The key to growing your business or propelling your career into the next decade lies in better understanding the present. Bhargava is regularly featured as an expert commentator in global media including Harvard Business Review, The Guardian and NPR. Kathryn also interviews Director of Cardiac Transplantation, The Sandra Atlas Bass Heart Hospital Dr. Brian Lima, author of “Heart To Beat: A Cardiac Surgeon's Inspiring Story of Success and Overcoming Adversity - The Heart Way.” He shares his story, giving everyone – not just aspiring physicians – the tools needed to be their best selves. Dr. Lima completed his medical training at Duke University and the Cleveland Clinic and published nearly 80 articles in peer-reviewed medical journals.

Kathryn interviews Founder, Non-Obvious Company Rohit Bhargava, WSJ bestselling author of “Non-Obvious Megatrends: How to See What Others Miss and Predict the Future.” You don't need to be a futurist or innovator to learn to think like one. The key to growing your business or propelling your career into the next decade lies in better understanding the present. Bhargava is regularly featured as an expert commentator in global media including Harvard Business Review, The Guardian and NPR. Kathryn also interviews Director of Cardiac Transplantation, The Sandra Atlas Bass Heart Hospital Dr. Brian Lima, author of “Heart To Beat: A Cardiac Surgeon's Inspiring Story of Success and Overcoming Adversity - The Heart Way.” He shares his story, giving everyone – not just aspiring physicians – the tools needed to be their best selves. Dr. Lima completed his medical training at Duke University and the Cleveland Clinic and published nearly 80 articles in peer-reviewed medical journals.

Commentary by Dr. Valentin Fuster

This week we review a recent paper on the topic of durable VAD's in congenital heart patients. Who is a candidate for such a device and what are the outcomes with these in this selected patient group? What are the impediments to their use? What role might public reporting have on the use of these devices and transplantation in general on the congenital heart population? We touch on all of these questions and more with Dr. Lauren Glass, Assistant Professor of Pediatrics at The Icahn School of Medicine at Mount Sinai - NYC where she is Associate Director of Heart Failure and Cardiac Transplantation. doi: 10.1097/MAT.0000000000001041

This week we review a recent paper on the topic of durable VAD's in congenital heart patients. Who is a candidate for such a device and what are the outcomes with these in this selected patient group? What are the impediments to their use? What role might public reporting have on the use of these devices and transplantation in general on the congenital heart population? We touch on all of these questions and more with Dr. Lauren Glass, Assistant Professor of Pediatrics at The Icahn School of Medicine at Mount Sinai - NYC where she is Associate Director of Heart Failure and Cardiac Transplantation. doi: 10.1097/MAT.0000000000001041

Commentary by Dr. Valentin Fuster

This week it's National Pediatric Transplant Week and we review a recent work on ECMO following cardiac transplant and speak with its first author, Assistant Professor of Pediatrics in Vanderbilt University, Dr. Justin Godown. How does the use of ECMO in the postoperative period influence outcomes in the short and long term? Are there differences in outcomes when it is used for patients with cardiomyopathy versus congenital heart disease? We review all of these and more with Dr. Godown. We speak also with Melissa McQueen of Transplantfamilies.org about her organization which strives to educate and support the families of children undergoing transplantation. Ms. McQueen's story is certainly an inspiring one. doi: 10.1111/petr.1341

This week it's National Pediatric Transplant Week and we review a recent work on ECMO following cardiac transplant and speak with its first author, Assistant Professor of Pediatrics in Vanderbilt University, Dr. Justin Godown. How does the use of ECMO in the postoperative period influence outcomes in the short and long term? Are there differences in outcomes when it is used for patients with cardiomyopathy versus congenital heart disease? We review all of these and more with Dr. Godown. We speak also with Melissa McQueen of Transplantfamilies.org about her organization which strives to educate and support the families of children undergoing transplantation. Ms. McQueen's story is certainly an inspiring one. doi: 10.1111/petr.1341

Heart Transplant SpecialistAlan L. Gass, M.D., FACC, is a Full Professor of Medicine at New York Medical College and Medical Director of Cardiac Transplantation and Mechanical Circulatory support at Westchester Medical Center in New York. Dr. Gass has appeared as a medical expert in Life Magazine, The New York Times, and on CNN, NBC, CNBC, and local New York news affiliates. He was featured in a one-hour documentary special, “A Change of Heart,” on Dateline NBC, which chronicled the poignant wait of several of his patients for a suitable donor heart.From 1991 until 2005, Dr. Gass served as the Director of Transplant Cardiology at New York’s Mount Sinai Medical Center, where he personally followed hundreds of patients in various stages of heart failure, 400 of whom were transplanted, achieving survival rates among the highest in the country. He is on the advisory board of HealthCorps – Dr. Mehmet Oz’ program aimed at combating childhood obesity using college students as mentors and teachers to raise awareness of the benefits of diet and exercise.Dr. Gass is on the Medical Advisory

This week we explore the world of cardiac transplantation with particular emphasis on the Fontan patient and transplantation. Outcomes are improving rapidly. Why is this? What about the liver and how are decisions made regarding cardiac versus cardiac+hepatic transplantation in this patient population? We review all of these questions with world authority on cardiac transplantation Dr. Daphne Hsu, Professor of Pediatrics, Chief of Pediatric Cardiology and Interim Chair of Pediatrics at Montefiore - Albert Einstein College of Medicine. Her insights into this complex patient group are valuable and novel. Article reviewed: DOI: 10.1016/j.athoracsur.2016.08.110

This week we explore the world of cardiac transplantation with particular emphasis on the Fontan patient and transplantation. Outcomes are improving rapidly. Why is this? What about the liver and how are decisions made regarding cardiac versus cardiac+hepatic transplantation in this patient population? We review all of these questions with world authority on cardiac transplantation Dr. Daphne Hsu, Professor of Pediatrics, Chief of Pediatric Cardiology and Interim Chair of Pediatrics at Montefiore - Albert Einstein College of Medicine. Her insights into this complex patient group are valuable and novel. Article reviewed: DOI: 10.1016/j.athoracsur.2016.08.110

Christiana Whallon's daughter, Jaylee, was listed for a heart transplant due to being born with hypoplastic left heart syndrome and going into congestive heart failure. In this episode, Christiana shares with Anna what it was like watching her daughter's health decline to the point where she had to be listed for a heart, what preparing for the transplant process was like for her family, and how she has survived even though her daughter never received a heart transplant.Support the show (https://www.patreon.com/HearttoHeart)

Help Ian interview all 120+ specialties by referring him to more physicians! Show notes! Dr. Zacharias, DO, is an Assistant Professor of Medicine at University Hospitals Cleveland Medical Center in the Division of Cardiology and Section of Heart Failure and Heart Transplantation. He is also currently the Medical Director of the Mechanical Circulatory Support program. Dr. Zacharias completed his undergraduate degree at John Carroll University in 2003; completed his medical degree at the Ohio University Heritage College of Osteopathic Medicine in 2007; completed an Internal Medicine residency, followed by a Cardiology fellowship both at the University of Massachusetts Memorial Medical Center by 2014 where he also served as a Chief Resident and as a Chief Cardiology Fellow. He then completed a fellowship in Advanced Heart Failure and Cardiac Transplantation at the University of Wisconsin Hospital and Clinics in 2015 before returning to Ohio to join the faculty at Cleveland Medical Center where he remains today. Dr. Zacharias’ clinical interests include invasive hemodynamics, temporary and durable mechanical circulatory support, and cardiac transplantation. He sees himself as a clinician educator and mentors local students interested in pursuing a career in medicine. At the completion of medical school he was a finalist for the Dean’s Award and at the completion of his Chief Resident year he was the recipient of the University of Massachusetts Department of Medicine Recognition Award for extraordinary contributions to medical education. Please enjoy with Dr. Michael Zacharias!

In this podcast, Mr Larbalestier shares his experiences with cardiac transplantation and guides us through some his POV footage of the first heart transplantation at the new Fiona Stanley Hospital.

Due to the complexity of the surgeries needed to help people with complex congenital heart defects, it is not uncommon for some survivors to suffer some neurological insults resulting in cognitive delays or even permanent neurological damage. How do parents of children with heart defects and neurological problems cope? What can parents do as their children become adults but are not able to function as adults? What kind of considerations need to be made for these children? Kathy Keller is the mother of an adult transplant survivor who has suffered two strokes and has dealt with neurological issues for a good deal of his life. Tune in to hear how Kathy and her husband Dennis have coped with this situation, what interventions Garrett has undergone to try to undo some of the damage caused by the strokes and what Garrett's prognosis is for the future.Support the show (https://www.patreon.com/HearttoHeart)

Host: Jennifer Caudle, DO Guest: Pavan Atluri, MD What are the latest advances in minimally invasive & robotic operations? And, which patients are candidates for robotic procedures? Host Dr. Jennifer Caudle welcomes Dr. Pavan Atluri, Assistant Professor of Surgery; Director of the Cardiac Transplantation and Mechanical Circulatory Assist Program; and, Director of the Minimally Invasive and Robotic Cardiac Surgery Program in the Division of Cardiovascular Surgery at the University of Pennsylvania. Dr. Atluri will discuss the latest advancements at Penn Medicine where he and his colleagues have been working for several years to perfect the robotic, minimally invasive, mitral valve repair procedure. And, don't forget to view some of the additional content below.

Host: Jennifer Caudle, DO Guest: Pavan Atluri, MD What are the latest advances in minimally invasive & robotic operations? And, which patients are candidates for robotic procedures? Host Dr. Jennifer Caudle welcomes Dr. Pavan Atluri, Assistant Professor of Surgery; Director of the Cardiac Transplantation and Mechanical Circulatory Assist Program; and, Director of the Minimally Invasive and Robotic Cardiac Surgery Program in the Division of Cardiovascular Surgery at the University of Pennsylvania. Dr. Atluri will discuss the latest advancements at Penn Medicine where he and his colleagues have been working for several years to perfect the robotic, minimally invasive, mitral valve repair procedure. And, don't forget to view some of the additional content below.

Interview with Lynne Warner Stevenson, MD, author of Crisis Awaiting Heart Transplantation: Sinking the Lifeboat

Xenotransplantation is thought to have the potential to solve the critical shortage of donor’s hearts with the development of genetically modified organ-source pigs and improvement of immunosuppressive strategies. As an appropriate preclinical animal model, the pig-to-baboon cardiac xenotransplantation model has been widely adopted. Traditionally, the evaluation of cardiac xenograft function in a pig-to-baboon model has been accomplished by means of palpation, ultrasound and biopsy. However, those methods pose increased risk of complications such as bleeding, infection, and apnea, leading to increased morbidity and mortality. Telemetric monitoring systems have been widely applied in the life science research involving a wide variety of animal models. These systems enable non-invasive, reliable and continuous measurements of cardiac xenograft function and provide information valuable for the improved understanding of transplantation pathophysiology. Importantly, these systems do not only avoid repeated anesthesia of the animals but also allow measurements independent from the effects of anesthetics. In preclinical pig-to-baboon xenotransplantations, telemetry systems have only been used in the heterotopic abdominal experiments. The aim of this study was the evaluation of a telemetry system for the monitoring of cardiac xenograft function after heterotopic thoracic cardiac xenotransplantation. Seven baboons underwent heterotopic thoracic cardiac xenotransplantation, for which double or triple transgenic pigs were used as donors. Hemodynamic parameters such as left ventricular peak systolic pressure (LVPSP), left ventricular end diastolic pressure (LVEDP), heart rate (HR), maximal rate of rise or decline of left ventricular pressure (±dP/dtmax), deviation of S-T segment, and the duration and amplitude of QRS complex in electrocardiogram (QRSA) were continuously monitored, using a telemetry system (DSI, St. Paul, MN, USA). Postoperatively, the serum levels of anti-pig antibodies (APA) were analyzed using a hemolytic assay with pig erythrocytes and the serum level of troponin was determined by the clinical laboratory on a daily basis. Based on the changes of troponin levels and APA levels, the baboons were grouped into elevated and unelevated. All parameters were compared between groups and between days. During the last two days of their survival, LVPSP, HR, +dP/dtmax, -dP/dtmax and QRSA were significantly lower in the baboons with elevated troponin compared to the group with unelevated troponin. Regarding specifically the group of baboons with elevation of troponin, the following observation was made: LVPSP, HR, -dP/dtmax, and QRSA decreased significantly on the day elevation of troponin was observed and the next day. In addition, The decrease of the parameter +dP/dtmax was significant one day after troponin increased. In contrast, the analysis of the group of baboons with elevated anti-pig antibodies revealed no significant changes in hemodynamic or electrocardiographic parameters before and after the rise of antibodies. In conclusion, this study demonstrates the ability of the telemetry system to assess changes in xenograft function in the heterotopic thoracic pig-to-baboon cardiac xenotransplant model. In particular, the parameters LVPSP, HR, ±dP/dtmax and QRSA are perceived to be reliable indicators of myocardial damage associated with graft rejection at an early stage following cardiac xenotransplantation. The use of the telemetry system might help to guide immunosuppressive therapy and further improve graft survival in future experiments.