Podcasts about Jaha

In this week's podcast episode in the Nutrition After Breast Cancer: Just the Facts series, I bring up the study that sparked that concern. I don't ignore things like this. I don't pretend they don't exist. If there's research being talked about, I want you to know about it. But here are the actual facts. The study was done in mice. The mice were made to consume about 40% of their diet in olive oil. And the rest of their diet was an obesogenic, high-carbohydrate diet designed to promote weight gain and metabolic dysfunction. That is not a Mediterranean diet. That is not olive oil drizzled over vegetables and salmon. That is not real life. It was a laboratory model designed to stress metabolism. Context matters. Deeply.   Resources Mentioned: Guide to Essential Fatty Acids: https://www.thebreastcancerrecoverycoach.com/oil Episode #326 Simplifying Seed Oils and Fatty Acids After Breast Cancer https://www.thebreastcancerrecoverycoach.com/326   Work with Laura: https://www.thebreastcancerrecoverycoach.com/health      REFERENCES: Obesity and Low-Fat Diet History Trends in Obesity Among Adults in the United States, 2005 to 2014 (CDC) https://www.cdc.gov/mmwr/preview/mmwrhtml/su6001a15.htm Documents obesity prevalence: 15.0% (1976-1980), 23.3% (1988-1994) Adult Obesity Prevalence Maps (CDC) https://pmc.ncbi.nlm.nih.gov/articles/PMC9611578/ 30.9% obesity prevalence (1999-2000) Adult Obesity Prevalence, 2021-2023 (CDC) https://www.cdc.gov/nchs/products/databriefs/db508.htm Current obesity prevalence: 40.3% How the Ideology of Low Fat Conquered America https://pubmed.ncbi.nlm.nih.gov/18296750/ Historical analysis of the low-fat movement Heart Disease Mortality Explaining the Decrease in U.S. Deaths from Coronary Disease, 1980–2000 (Ford et al., NEJM 2007) https://www.nejm.org/doi/full/10.1056/NEJMsa053935 ~51% decline in men, ~49% decline in women 47% from medical treatments, 44% from risk factor changes Obesity and diabetes offset gains by 8% and 10% Heart Disease Mortality in the United States, 1970 to 2022 https://www.ahajournals.org/doi/10.1161/JAHA.124.038644 89% decrease in heart attack deaths 81% increase in heart failure and other heart disease deaths Omega-3s, Inflammation, and Cancer Omega-6/Omega-3 Ratios and Modern Diets Ancestral ratios: 1:1 to 4:1 Modern Western diet: 15:1 to 20:1 Impact on eicosanoid metabolism and cellular inflammation DHA and Triple Negative Breast Cancer (Journal of Nutritional Biochemistry, 2019) DHA induced cell death in TNBC cells Mechanism: altered membrane composition, increased oxidative stress in cancer cells High-Fat Diets and TNBC Metastasis (Preclinical Studies) CD36-mediated fatty acid uptake in TNBC Oleic acid-rich diets promoting metastasis in mouse models Importance of tumor phenotype and metabolic flexibility   Let's Connect! If this episode helped you breathe a little easier, please share it with a friend or leave a review. Every share helps spread this message of hope, healing, and whole-person wellness.

Nordmark Pod får besök av gitarristen, låtskrivaren och producenten Pedro Sanches aka Håkan Sörle från Korslagda!Det samtalas om och att; kastade skidorna när jag upptäckte rock ´n rollen och röda prins, snabbt har det gått, finlandsfärja till Tallin, Ubbe vet knappt hur en mickrofon fungerar, knappt repat, Baboon Show, Mando Diao, En sån här chans får man bara en gång i livet, Mello, hela bandet är bara tur! Det borde vara min tur då Ubbe inte kan nåt men det är det som är bra, larmtekniker från Älvdalen, den högljudda minoriteten, vi ville inte ha fans, tjocka K;n, Persbrandt, arrangörer ville inte boka Korslagda Kukar, jag har ingen utbildning, ett annorlunda jobb, jag är en kuf, ska du rulla tummarna!? Jaha här sitter ni och leker, jag repeterar, men GÅ! Vem går och pissar först och så håller det på..Mäktigt! Produktion av NordmarkEditering av NordmarkMix av Nordmark

Please join guests Drs. Nate Sznycer-Taub (UMichigan/C.S. Mott Children's Hospital) and Asaad Beshish (Emory/Children's Healthcare of Atlanta) in discussing their landmark paper “Hyperoxia During Neonatal Cardiopulmonary Bypass Is Associated With Worse Clinical Outcomes: A Multi-Institutional Study” in JAHA 2025. Host: Dr. Maria Batsis (Stanford/Stanford Children's Hospital). Co-host/Editor/Producer: Dr. Saidie Rodriguez (Emory/Children's Healthcare of Atlanta). Sponsor: Children's Hospital Colorado Heart Institute Beshish, A. G., Kwiatkowski, D. M., Sznycer-Taub, N., Costello, J. M., Jergel, A., Gillespie, S., Cashen, K., Asfari, A., Batsis, M., Buckley, J. R., Chlebowski, M. M., Flores, S., Goldshtrom, N., Migally, K., Mills, K. I., Radman, M. R., Reddy, C., Shutes, B., Riley, C. M., Narasimhulu, S. S., … Collaborative Research from the Pediatric Intensive Care Society (CoRe‐PCICS) Investigators (2026). Hyperoxia During Neonatal Cardiopulmonary Bypass Is Associated With Worse Clinical Outcomes: A Multi-Institutional Study. Journal of the American Heart Association, 15(1), e045890. https://doi.org/10.1161/JAHA.125.045890

Mama Ganuush is back home in San Francisco after hosting the first JAHA Film Festival in December in Lisbon. The festival features all trans-focused films from the Global South, and begins screening online starting this Friday, Feb. 14. JAHA Film Festival https://www.jahafilmfestival.com/ Trans Liberation Film School https://www.jahafilmfestival.com/transliberationfilmschool

Justin, Cory, and Jaha discuss Trump's social media post demeaning the Obamas. They also discuss several aspects of the Epstein documents and answer if empathy is a thing.   Show Notes: https://x.com/matthewstoller/status/2018388941389373748?s=46 https://youtu.be/28LEvzCt9Rk?si=S7_j-eMN8OWYDX_v https://x.com/albertmohler/status/2018806756676096037?s=46 Learn more about your ad choices. Visit podcastchoices.com/adchoices

Många har grubblat över existensens själva existens. Helena Granström ansluter sig skaran. Lyssna på alla avsnitt i Sveriges Radios app. ESSÄ: Detta är en text där skribenten reflekterar över ett ämne eller ett verk. Åsikter som uttrycks är skribentens egna.Om man ska tro filosofen Arthur Schopenhauer, erbjuder universum en lika pockande som gäckande gåta för varje tänkande person: ”Ju lägre stående en människa är i intellektuellt avseende, desto mindre förbryllande och mystisk ter sig själva existensen för henne.” Det vill säga: Har man bara något bakom pannbenet, så inser man att tillvaron är obegriplig: inte bara till sin natur, utan i det att den alls finns.Ska man tro honom? Tja, den som önskar belägg för hans tes kan i alla fall utan svårighet finna en uppsjö av intellektuellt ambitiösa personer som upptagits just av bryderier över existensens själva existens.1700-talstänkaren Gottfried Wilhelm Leibniz, till exempel, som efter att ha fastslagit sin berömda princip att varje sakförhållande också kan ges en fullständig förklaring, konstaterade att den första fråga som därpå infann sig var: ”Varför finns det något, snarare än ingenting?”En formulering som drygt två sekler senare ekade hos hans tyske kollega Martin Heidegger som också han ansattes av frågan: ”Varför är överhuvudtaget något varande, och inte snarare intet?”Han man väl låtit sig upptas av denna undran, bleknar alla andra gåtor bort i dess bländande sken. Som ett annat högstående intellekt vid namn Ludvig Wittgenstein formulerat det är det mystiska ”inte hur världen är, utan att den är”.Och varför är den då?Det visar sig att frågan har minst lika många svar som den har möjliga invändningar mot de givna svaren – som den har möjliga underkännanden av själva frågan.Till att börja med kan man ju undra hur ett tillfredsställande svar skulle kunna se ut? Vilken orsak till världens existens skulle inte i sin tur kräva en orsak, så att man i slutändan inte hade åstadkommit något alls?Leibniz själv tyckte sig kunna besvara frågan så snart han ställt den: Orsaken till världens existens är Gud.Jaha. Men vad är i så fall orsaken till att Gud finns?Jo, svarar Leibniz, det är Gud.Vilket är det som i Leibniz mening skiljer Gud och universum åt: Universum hade lika gärna inte kunnat existera, och därför kräver dess existens en förklaring. Gud, däremot, utgör sin egen nödvändighet: I Guds identitet, ingår egenskapen att han existerar. Orsaken till att Gud finns är Gud.Ett besläktat argument är det som går under det arabiska namnet Kalam, och som gör gällande att universum behöver förklaras eftersom det en gång har uppstått, medan Gud är ett tidlöst väsen som alltid har funnits, och som sådant kan förbli oförklarat.Utifrån ett sådant resonemang kan den kosmologiska teorin om världsalltets födelse i Big Bang för knappt 14 miljarder år sedan med en del god vilja betraktas som belägg för en övernaturlig varelses inblandning. Men å andra sidan kan man invända att de flesta varianter av Big Bang-modellen gör gällande att tiden uppstod först i och med ursmällen, så att universum faktiskt visst alltid har existerat, om man med alltid menar ”vid alla ögonblick i tiden”.Och därmed har man gett sig in på fysikernas försök att besvara den uppenbarligen svårbesvarade frågan om orsaken till världens existens. Varför något snarare än intet? Vad sägs om svaret: ”Därför att ett instabilt vakuum uppstod som en fluktuation i den absoluta intigheten, som i fysikaliska termer kan beskrivas som en sluten fyrdimensionell rumtid med radien noll. Detta vakuum genomsyrades av kvantfält vars fluktuationer i sin tur sådde fröet till det universum vi ser idag”?Ja, det får åtminstone mig att undra om allt ståhej kring frågan om existensens orsak åtminstone till viss del är ett resultat av de högtstående intellektens tendens att intellektualisera lite för mycket?För hur mycket har det intet som enligt Heidegger gör sig påmint i stunder av bottenlös förtvivlan eller oförstörd lycka, egentligen att göra med den teoretiska fysikens bild av ett universum som ännu inte finns? Kanske faktiskt nästan – intet?Men en sak kan man i alla fall säga om fysikernas rumtid utan utsträckning: Den är verkligen intet, mer intet än en tom rumtid, mer intet än ett tomt rum utan tid, mer intet än – ja, det mesta. Det enda som måste sägas ha funnits från början i denna modell är de naturlagar som tillåter ett kvantfält att tunnla fram ur detta totala intet. Men på vilket sätt fanns i så fall de?Frågan om varför det finns något för oss alltså oförhappandes vidare till frågan om huruvida fysikens lagar existerar inte bara oberoende av den mänskliga tanken, utan till och med oberoende av att det finns någon fysikalisk tillvaro som de kan beskriva. Och där har vi hamnat utan att vad det verkar ha kommit så särskilt mycket närmare ett svar på frågan om varför något existerar alls.Och ju mer man tänker på saken, desto mindre uppenbart tycks det att upptagenheten vid denna fråga är tecken på intellektuell finess. Är den i själva verket inte, som redan Immanuel Kant ville göra gällande, bara en effekt av att ha utvidgat idén om orsak och verkan längre än vad som är rimligt? Oavsett hur naturlig kausaliteten ter sig för oss, finns det nämligen mycket som tyder på att den inte gäller på de minsta partiklarnas kvantmekaniska nivå, och att universums födelse var en händelse då kvantmekaniken spelade roll har vi mycket goda skäl att tro. Och dessutom: Om tiden uppstod först i och med den stora smällen, hur är det möjligt att tala om en orsak som föregår den? Är det något som behövs för att orsakssamband ska kunna upprättas är det väl tid.För den som vill gå ännu djupare i sin kritik av frågan om varför något istället för intet, finns inte heller några hinder. Varför tycker vi exempelvis att existensen av något behöver motiveras, men inte existensen av intet? Varför ska intigheten på detta vis betraktas som ett naturligt grundtillstånd? Enligt filosofen Adolf Grünbaum är det ingen slump att frågan började ställas först i den moderna eran: De gamla grekerna upptogs inte av den, och inte heller antika indiska tänkare. Skälet? De var inte fostrade i den kristna tro som postulerar en skapelse ur intet, ex nihilo. Först i och med den kristna läran om en allsmäktig gud som häver existensen upp ur intet och därefter oupphörligt verkar för att upprätthålla den, skulle vi inte vara så övertygade om att varje avvikelse från intigheten kräver en förklaring. Detta alltså enligt Grünbaum. Som matematiker är jag också frestad att inflika att det finns många fler sätt att existera på, än det finns att inte existera på, vilket väl i sig är en sorts statistiskt argument för någontinget. Kanske är frågan om varför världen är i själva verket ett skenproblem?Ja, vem vet. Men hur som helst finns det också, vad Schopenhauer än påstod, tänkande personer som intar en helt annan hållning till problematiken än den djupsinnigt grubblande. Som exempelvis filosofen Sidney Morgenbesser, som när den eviga frågan ställdes till honom helt sonika snäste ifrån: ”Äsch! Även om det fanns intet skulle ni säkert inte vara nöjda ändå!”Helena Granströmförfattare med bakgrund inom fysik och matematikLitteraturJim Holt – Why does the world exist? (Liveright, 2012) Niayesh Afshordi och Phil Halper – Battle of the big bang (University of Chicago Press, 2025) Thomas Hertog – Om tidens uppkomst (Fri Tanke, 2023) Philip Goff – Meningen med universum (Fri Tanke, 2025)

On this week’s episode, we’re continuing our Guidelines Series exploring the 2022 ESC/ERS Guidelines for the diagnosis and treatment of Pulmonary Hypertension. If you missed our first episode in the series, give it a listen to hear about the most recent recommendations regarding Pulmonary Hypertension definitions, screening, and diagnostics. Today, we’re talking about the next steps after diagnosis. Specifically, we’ll be discussing risk stratification, establishing treatment goals, and metrics for re-evaluation. We’ll additionally introduce the mainstays of pharmacologic therapy for Pulmonary Hypertension. Meet Our Co-Hosts Rupali Sood  grew up in Las Vegas, Nevada and made her way over to Baltimore for medical school at Johns Hopkins. She then completed her internal medicine residency training at Massachusetts General Hospital before returning back to Johns Hopkins, where she is currently a pulmonary and critical care medicine fellow. Rupali’s interests include interstitial lung disease, particularly as related to oncologic drugs, and bedside medical education. Tom Di Vitantonio  is originally from New Jersey and attended medical school at Rutgers, New Jersey Medical School in Newark. He then completed his internal medicine residency at Weill Cornell, where he also served as a chief resident. He currently is a pulmonary and critical care medicine fellow at Johns Hopkins, and he’s passionate about caring for critically ill patients, how we approach the management of pulmonary embolism, and also about medical education of trainees to help them be more confident and patient centered. Key Learning Points 1) Episode Roadmap How to set treatment goals, assess symptom burden, and risk-stratify patients with suspected/confirmed pulmonary arterial hypertension (PAH). What tools to use to re-evaluate patients on treatment Intro to major PAH medication classes and how they map to pathways. 2) Case-based diagnostic reasoning Patient: 37-year-old woman with exertional dyspnea, mild edema, abnormal echo, telangiectasias + epistaxis → raises suspicion for HHT (hereditary hemorrhagic telangiectasia) and/or early connective tissue disease. Key reasoning move: start broad (Groups 2–5) and narrow using history/exam/testing. In a young patient without obvious left heart or lung disease, think more about Group 1 PAH (idiopathic/heritable/associated). HHT teaching point: HHT can cause PH in more than one way: More common: high-output PH from AVMs (often hepatic/pulmonary) Rare (1–2% mentioned): true PAH phenotype (vascular remodeling; associated with ALK1 in some patients), behaving like Group 1 PAH. 3) Functional class assessment WHO Functional Class: Class I: no symptoms with ordinary activity, only with exertion Class II: symptoms with ordinary activity Class III: symptoms with less-than-ordinary activity (can't do usual chores/shopping without dyspnea) Class IV: symptoms at rest Practical bedside tip they give: Ask if the patient can walk at their own pace or keep up with a similar-age peer/partner. If not, think Class II (or worse). 4) Risk stratification at diagnosis: why, how, and which tools Big principle: treatment choices are driven by risk, and the goal is to move patients to low-risk quickly. ESC/ERS approach at diagnosis (as described): Use a 3-strata model predicting 1-year mortality: Low: 20% ESC/ERS risk assessment variables (10 domains discussed): Clinical progression, signs of right heart failure, syncope WHO FC Biomarkers (NT-proBNP) Exercise capacity (6MWD) Hemodynamics Imaging (echo; sometimes cardiac MRI) CPET (peak VO₂; VE/VCO₂ slope) They note: even if you don't have everything, the calculator can still be useful with ≥3 variables. REVEAL 2.0: Builds on similar core variables but adds further patient context (demographics, renal function, BP, DLCO, etc.) Case result: both tools put her in intermediate risk (ESC/ERS ~1.6; REVEAL 2.0 score 8), underscoring that mild symptoms can still equal meaningful mortality risk. 5) Treatment goals and follow-up philosophy What they explicitly prioritize: Help patients feel better, live longer, and stay out of the hospital Use risk tools to communicate prognosis and to track improvement Reassess frequently (they mention ~every 3 months early on) until low risk is achieved “Time-to-low-risk” is an important treatment goal Also emphasized: The diagnosis is psychologically heavy; patients need clear counseling, reassurance about the plan, and connection to support groups. 6) Medication classes for the treatment of PAH Nitric oxide–cGMP pathway PDE5 inhibitors: sildenafil, tadalafil Soluble guanylate cyclase stimulator: riociguat Important safety point: don't combine PDE5 inhibitors with riociguat (risk of significant hypotension/hemodynamic effects) Endothelin receptor antagonists (ERAs) “-sentan” drugs: bosentan (less used due to side effects/interactions), ambrisentan, macitentan Teratogenicity emphasized Hepatotoxicity that requires LFT monitoring Can cause fluid retention and peripheral edema Prostacyclin pathway Prostacyclin analogs/agonists: Epoprostenol (potent; short half-life; IV administration) Treprostinil (IV/SubQ/oral/inhaled options) Selexipag (oral prostacyclin receptor agonist) 7) Sotatercept (post-guidelines) They note sotatercept wasn't in 2022 ESC/ERS but is now “a game changer” in practice: Mechanism: ligand trap affecting TGF-β signaling / remodeling biology Positioned as potentially more disease-modifying than pure vasodilators Still evolving: where to place it earlier vs later in regimens is an active question in the field 8) How risk category maps to initial treatment intensity General approach they outline: High risk at diagnosis: parenteral prostacyclin (IV/SubQ) strongly favored, often aggressive early Intermediate risk: at least dual oral therapy (typically PDE5i + ERA); escalate if not achieving low risk Low risk: at least one oral agent; many still use dual oral depending on etiology/trajectory For the case: intermediate-risk → start dual oral therapy (they mention tadalafil + ambrisentan as a typical choice), reassess in ~3 months; add a third agent (e.g., selexipag/prostacyclin pathway) if not low risk.  References and Further Reading Humbert M, Kovacs G, Hoeper MM, Badagliacca R, Berger RMF, Brida M, Carlsen J, Coats AJS, Escribano-Subias P, Ferrari P, Ferreira DS, Ghofrani HA, Giannakoulas G, Kiely DG, Mayer E, Meszaros G, Nagavci B, Olsson KM, Pepke-Zaba J, Quint JK, Rådegran G, Simonneau G, Sitbon O, Tonia T, Toshner M, Vachiery JL, Vonk Noordegraaf A, Delcroix M, Rosenkranz S; ESC/ERS Scientific Document Group. 2022 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension. Eur Heart J. 2022 Oct 11;43(38):3618-3731. doi: 10.1093/eurheartj/ehac237. Erratum in: Eur Heart J. 2023 Apr 17;44(15):1312. doi: 10.1093/eurheartj/ehad005. PMID: 36017548. Condon DF, Nickel NP, Anderson R, Mirza S, de Jesus Perez VA. The 6th World Symposium on Pulmonary Hypertension: what’s old is new. F1000Res. 2019 Jun 19;8:F1000 Faculty Rev-888. doi: 10.12688/f1000research.18811.1. PMID: 31249672; PMCID: PMC6584967. Maron BA. Revised Definition of Pulmonary Hypertension and Approach to Management: A Clinical Primer. J Am Heart Assoc. 2023 Apr 18;12(8):e029024. doi: 10.1161/JAHA.122.029024. Epub 2023 Apr 7. PMID: 37026538; PMCID: PMC10227272. Hoeper MM, Badesch DB, Ghofrani HA, Gibbs JSR, Gomberg-Maitland M, McLaughlin VV, Preston IR, Souza R, Waxman AB, Grünig E, Kopeć G, Meyer G, Olsson KM, Rosenkranz S, Xu Y, Miller B, Fowler M, Butler J, Koglin J, de Oliveira Pena J, Humbert M; STELLAR Trial Investigators. Phase 3 Trial of Sotatercept for Treatment of Pulmonary Arterial Hypertension. N Engl J Med. 2023 Apr 20;388(16):1478-1490. doi: 10.1056/NEJMoa2213558. Epub 2023 Mar 6. PMID: 36877098. Ruopp NF, Cockrill BA. Diagnosis and Treatment of Pulmonary Arterial Hypertension: A Review. JAMA. 2022 Apr 12;327(14):1379-1391. doi: 10.1001/jama.2022.4402. Erratum in: JAMA. 2022 Sep 6;328(9):892. doi: 10.1001/jama.2022.13696. PMID: 35412560.

Cardiologist Bob Harrington talks to Mitch Elkind, chief science officer for Brain Health and Stroke at the AHA, about the heart-brain connection and why what's good for the brain is good for the heart. This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington Life's Essential 8: Updating and Enhancing the American Heart Association's Construct of Cardiovascular Health: A Presidential Advisory From the American Heart Association  https://www.ahajournals.org/doi/10.1161/CIR.0000000000001078 Migraine Headache: An Under-Appreciated Risk Factor for Cardiovascular Disease in Women https://www.ahajournals.org/doi/10.1161/JAHA.119.014546 Cardiovascular disease patients have increased risk for comorbidity: A cross-sectional study in the Netherlands https://doi.org/10.1080/13814788.2017.1398318 Characteristics and treatment of midlife-onset epilepsy: A 24-year single-center, retrospective study https://doi.org/10.1002/epd2.20253 Traumatic Brain Injury and Risk of Neurodegenerative Disorder https://doi.org/10.1016/j.biopsych.2021.05.025 Cardiac Changes in Parkinson's Disease: Lessons from Clinical and Experimental Evidence https://doi.org/10.3390/ijms222413488 The neuropathological diagnosis of Alzheimer's disease https://doi.org/10.1186/s13024-019-0333-5 Failed Semaglutide for Early Alzheimer's Not the End of the Road? https://www.medscape.com/viewarticle/failed-semaglutide-early-alzheimers-not-end-road-2025a1000y4l Atrial Fibrillation and Dementia: A Report From the AF-SCREEN International Collaboration https://doi.org/10.1161/circulationaha.121.055018 Reduced regional cerebral blood flow in patients with heart failure https://doi.org/10.1002/ejhf.874 Heart-brain Interactions in Heart Failure https://doi.org/10.15420/cfr.2018.14.2 While You Were Sleeping, the Brain's 'Waste Disposal System' Was at Work https://www.medscape.com/viewarticle/while-you-were-sleeping-brains-waste-disposal-system-was-2025a1000mbb Repurposing Semaglutide and Liraglutide for Alcohol Use Disorder https://doi.org/10.1001/jamapsychiatry.2024.3599 2025 AHA/ACC/AANP/AAPA/ABC/ACCP/ACPM/AGS/AMA/ASPC/NMA/PCNA/SGIM Guideline for the Prevention, Detection, Evaluation and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines https://www.ahajournals.org/doi/10.1161/CIR.0000000000001356 "VOODOO" Death https://ajph.aphapublications.org/doi/full/10.2105/AJPH.92.10.1593 Longitudinal brain ageing after stroke: a marker for neurodegeneration and its relevance for upper limb motor outcome https://doi.org/10.1093/braincomms/fcaf299 Unlocking Longevity: Aging Reimagined  https://www.medscape.com/viewarticle/1002241 You may also like: Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology https://www.medscape.com/twic Questions or feedback, please contact news@medscape.net

Jaha å hur ska man leva sitt liv 2026? Surret vet, typ. I alla fall vad som är riktigt ute att göra på instagram. Dessutom: det här klarar inte vi millennials av. Och så har Hanna insett hur fruktansvärt Basic hon är (men det hade Nea förstått för längesen…).

The limits of knowing coronary artery disease anatomy, fish oil and AF risk, a new drug for PSVT, and maybe I was wrong about a drug for AF conversion (the RAFF4 trial). These are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I Prediction of CAD is hard — even if you have anatomy CCTA in Prediction of First Coronary Events https://jamanetwork.com/journals/jama/fullarticle/2841255 II Fish Oil and AF (and as a bonus we learn again about analytic flexibility) Are Fish Oils on the Hook for AF Risk? https://www.medscape.com/viewarticle/995290 Omega-3 and Fish Oil Use With Risk of AF  https://www.ahajournals.org/doi/full/10.1161/JAHA.125.043031 Effect of Long-Term Marine Omega-3 Fatty Acids on the Risk of AF https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.121.055654 RESPECT-EPA Trial https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.123.065520 Association Between Omega-3 Fatty Acids and AF: Meta Analysis https://link.springer.com/article/10.1007/s10557-021-07204-z Fish Oil Supplements and Risk of AF https://academic.oup.com/eurjpc/article/29/14/1911/6679610 Editorial: Fish Oil Supplements and AF Risk https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.121.057464 III A New Drug for PSVT FDA Approval https://www.fda.gov/drugs/news-events-human-drugs/fda-approves-drug-type-abnormally-fast-heart-rhythm RAPID trial https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)00776-6/fulltext IV AF Conversion with Vernakalant RAFF4 Trial https://www.bmj.com/content/391/bmj-2025-085632.long Editorial: Rapid Cardioversion for Acute AF https://www.bmj.com/content/391/bmj.r2264 VI A Quick Note on HFpEF Med Op-Ed: Avalanche Survival, HFpEF Skepticism, and More https://www.medscape.com/viewarticle/med-op-ed-avalanche-survival-hfpef-skepticism-and-more-2026a1000012 You may also like: The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net

Acute Coronary Syndrome refers to a spectrum of conditions including Unstable Angina, Non ST Elevation Myocardial Infarction and ST Elevation Myocardial Infarction. In this video we look at the pathology behind acute coronary syndrome, the differences between Unstable angina, NSTEMI and STEMI, as well as the signs and symptoms, diagnosis (including ECG changes!) and treatment of each. PDFs available here: https://rhesusmedicine.com/pages/cardiologyConsider subscribing (if you found any of the info useful!): https://www.youtube.com/channel/UCRks8wB6vgz0E7buP0L_5RQ?sub_confirmation=1Buy Us A Coffee!: https://www.buymeacoffee.com/rhesusmedicineTimestamps:0:00 What is Acute Coronary Syndrome - Acute Coronary Syndrome Definition0:25 Coronary Artery Anatomy1:17 Acute Coronary Syndrome Pathology - Atherosclerosis 2:08 Acute Coronary Syndrome Pathology - Unstable Angina vs Non ST Elevation Myocardial Infarction vs ST Elevation Myocardial Infarction3:00 Acute Coronary Syndrome Risk Factors3:23 Signs and Symptoms of Acute Coronary Syndrome4:17 Acute Coronary Syndrome Diagnosis - ECG STEMI5:45 Acute Coronary Syndrome Diagnosis - ECG NSTEMI and Unstable Angina6:42 Acute Coronary Syndrome Diagnosis - Cardiac Troponin I 7:11 Acute Coronary Syndrome Diagnosis - Imaging7:42 Treatment of Acute Coronary SyndromeLINK TO SOCIAL MEDIA: https://www.instagram.com/rhesusmedicine/ReferencesBritish National Formulary (BNF), 2015. Acute coronary syndromes – treatment summary. [online] Available at: https://bnf.nice.org.uk/treatment-summary/acute-coronary-syndromes.html. BNFTeachMeAnatomy, 2025. Heart vasculature. [online] Available at: https://teachmeanatomy.info/thorax/organs/heart/heart-vasculature/. TeachMeAnatomy+1DeVon, H.A., 2020. Typical and atypical symptoms of acute coronary syndrome. Journal of the American Heart Association, 9:e015539. [online] Available at: https://www.ahajournals.org/doi/10.1161/JAHA.119.015539. AHA JournalsWarren, A., 2020. Acute coronary syndrome: risk factors, diagnosis and treatment. The Pharmaceutical Journal. [online] Available at: https://pharmaceutical-journal.com/article/ld/acute-coronary-syndrome-risk-factors-diagnosis-and-treatment. The Pharmaceutical JournalLife in the Fast Lane (LITFL), 2021. Acute coronary syndromes. [online] Available at: https://litfl.com/acute-coronary-syndromes/. Life in the Fast Lane • LITFLDisclaimer: Please remember this podcast and all content from Rhesus Medicine is for educational and entertainment purposes only and is not a guide to diagnose or to treat any form of condition. The content is not to be used to guide clinical practice and is not medical advice. Please consult a healthcare professional for medical advice.

===== MDJ Script/ Top Stories for December 19th Publish Date:  December 19th    Commercial: From the BG AD Group Studio, Welcome to the Marietta Daily Journal Podcast.    Today is Friday, December 19th and Happy Birthday to Al Kaline I’m Keith Ippolito and here are the stories Cobb is talking about, presented by Times Journal South Cobb mayors speak on accomplishments, future Jaha Howard wins runoff for Georgia Senate District 35 Cobb County staff trade desk work for Christmas carols Plus, Leah McGrath from Ingles Markets on saturated fats As well as Shane Delancey the Director of the Christmas Tradition at the Strand Theatre All of this and more is coming up on the Marietta Daily Journal Podcast, and if you are looking for community news, we encourage you to listen and subscribe!  Now here is Shane Delancey the Director of the Christmas Tradition at the Strand Theatre BREAK: THE STRAND STORY 1: South Cobb mayors speak on accomplishments, future  Three mayors, three cities, and a lot to reflect on. Austell Mayor Ollie Clemons, Mableton Mayor Michael Owens, and Powder Springs Mayor Al Thurman gathered at the Riverside EpiCenter to talk about 2025 wins and what’s next for 2026 during the State of South Cobb event. Clemons? He’s proud of Austell’s bold move to raise the millage rate for the first time in decades. “It’s about reinvesting in our community,” he said, pointing to plans for downtown revitalization and hiring a city manager—finally. Owens celebrated Mableton’s new departments and leadership team, calling 2025 a year of “building the foundation.” Next year? It’s all about community engagement and growth. Thurman highlighted Powder Springs’ shiny new city hall and parking garage, plus job-creating developments. His focus for 2026? Sustainable growth and leaving a legacy of leadership. STORY 2: Jaha Howard wins runoff for Georgia Senate District 35 Jaha Howard pulled off a narrow win Tuesday night, defeating fellow Democrat Roger Bruce in the runoff for state Senate District 35. Unofficial results show Howard, a dentist and former Cobb school board member, edging out Bruce with 51.9% of the vote to Bruce’s 48.1%. The seat, which covers parts of Cobb and Fulton counties, was left open when Jason Esteves stepped down to run for governor. Howard credited his win to personal outreach—hundreds of phone calls, he said, to build trust. “People want to feel heard,” he said. Bruce’s campaign struggled with name recognition, especially in Cobb. STORY 3: Cobb County staff trade desk work for Christmas carols  Glover Park got a dose of holiday magic Tuesday, thanks to Cobb County’s newest choir, “Cobb County Sonic Sound” (or, as they like to call themselves, “CoCo SoSo”). Led by Dr. Jatunn Gibson, head of the county’s Public Services Agency, the group—decked out in festive sweaters and holiday flair—belted out classics like “Joy to the World” and “White Christmas.” Oh, and they’ve got their own band too, all county employees. Between songs, they performed skits about elves saving Christmas. “It’s all about fun and camaraderie,” said Grace Williams, a choir member. “We’re connecting beyond work—and it’s a blast.” We have opportunities for sponsors to get great engagement on these shows. Call 770.799.6810 for more info.  We’ll be right back. Break: Villa Rica Wonderland Train STORY 4: Jason Gaines named Mableton Citizen of the Year  Jason Gaines didn’t see it coming. This week, he was named the 2025 Mableton Citizen of the Year at the South Cobb Area Council meeting, and the surprise left him, well, a little speechless. “It just warms my heart,” Gaines said. “To know the work I’ve done is appreciated like this—it’s humbling.” Gaines, who’s the director of planning at Croy Engineering and chairs the Mableton Development Authority Board, was honored by Mayor Michael Owens. “Jason’s been a force,” Owens said. “His expertise and passion have shaped this community at such a critical time.” The guy’s résumé? Stacked. Leadership programs, board memberships—he’s everywhere. STORY 5: Anderson steps down as Walker football coach TJ Anderson pulled off something close to miraculous in 2025. With just 23 players—yes, 23—he guided Walker through a grueling 10-game season. The Wolverines finished 2-8, but they still earned a spot in the Class A-AAA Private state playoffs. Unfortunately, injuries piled up, and the team had to decline the bid. “We had to make the best decision for our kids,” Anderson said, reflecting on the tough call. But that season? It was his last. Anderson announced on X that he’s stepping down as Walker’s head coach after three years. “It’s been a journey,” he wrote, thanking the community and his family. BRAVES: Ha-Seong Kim is staying put in Atlanta—at least for another year. The 30-year-old shortstop signed a one-year, $20 million deal with the Braves on Monday, locking him in as the team’s starter for 2026. Not bad, considering he turned down a $16 million option just last month and walked away with an extra $4 million. Kim joined the Braves late last season, claimed off waivers from Tampa Bay on Sept. 1. He made an immediate impact, hitting .309 with a .372 OBP, three homers, and 12 RBIs in his first 19 games. Sure, he cooled off at the end—1-for-19 in the last five games—but the Braves clearly see his potential. Kim’s journey hasn’t been without bumps. Injuries sidelined him for much of 2025 with the Rays, where he hit just .214 in 24 games. But let’s not forget—this guy won a Gold Glove with the Padres in 2023 and has 84 career stolen bases. The Braves are betting on a bounce-back. And if Kim can channel his San Diego form, he could be a 3-4 WAR player. High hopes, but hey, the talent’s there. I'm Keith Ippolito and that’s your MDJ Sports Minute. And now here is Leah McGrath from Ingles Markets on saturated fats We’ll have closing comments after this. Break: INGLES 8 Signoff-   Thanks again for hanging out with us on today’s Marietta Daily Journal Podcast. If you enjoy these shows, we encourage you to check out our other offerings, like the Cherokee Tribune Ledger Podcast, the Marietta Daily Journal, or the Community Podcast for Rockdale Newton and Morgan Counties. Read more about all our stories and get other great content at mdjonline.com Did you know over 50% of Americans listen to podcasts weekly? Giving you important news about our community and telling great stories are what we do. Make sure you join us for our next episode and be sure to share this podcast on social media with your friends and family. Add us to your Alexa Flash Briefing or your Google Home Briefing and be sure to like, follow, and subscribe wherever you get your podcasts. Produced by the BG Podcast Network Show Sponsors: www.ingles-markets.com See omnystudio.com/listener for privacy information.

Justin, Jaha, and Cory discuss the massive fraud that occurred in Minneapolis and the political and racial implications. They also discuss Rep. Jasmine Crockett getting into the Texas Senate primary and their favorite Christmas song and movie.   Show Notes: https://www.nytimes.com/2025/11/29/us/fraud-minnesota-somali.html https://www.notus.org/senate/jasmine-crockett-nrsc-texas-senate Learn more about your ad choices. Visit podcastchoices.com/adchoices

Delving into the latest JAHA review on immune checkpoint inhibitors and the heart has been illuminating

Welcome! and Thank you for listening.  Move it or loose it for sure but how should be move and how often.  I made some observations at this year's Turkey trot that I think you might find helpful.  Vitamin D is not just about bones but your immune system, your heart, and many other things.  The sun is the best source because there are so many other mechanisms in the body fueled by the sun's photons.  However, getting adequate vitamin D is a must.  What about DHA.  Can we just rely on alpha linolenic acid from plants?   The question becomes live or thrive?  I believe we can do better with excellent DHA levels and I will discuss this during the podcast.  Email me: jami@doctordulaney.com Website to join my practice/ become a newsletter subscriber: doctordulaney.com Ebook: doctordulaney.com/.powerful-plates-ebook/?mc_cid=cc24587ac Cookbook: amzn.to/4onHVe4 Water distillers: mypurewater.com?sld-jdulaney. discount code: cleanwaterforsophie https://pubmed.ncbi.nlm.nih.gov/22570739/https://www.ncbi.nlm.nih.gov/books/NBK221706/ The Science of Running: Steve Magness https://www.ahajournals.org/doi/10.1161/JAHA.112.000030https://pubmed.ncbi.nlm.nih.gov/40465176/      

Don't forget to follow us on Instagram at officialdrunkblackhistory!On this month's episode, Brandon is joined by investigative journalist and harpist Jaha Nailah Avery to discuss learning new things, traveling on your own, and the life and career of acclaimed writer Dorothy West. DBH Links:- https://www.instagram.com/officialdrunkblackhistory- https://www.drunkblackhistory.com/ - https://www.youtube.com/@drunkblackhistory- https://www.teepublic.com/t-shirt/16706941-dbh-logoGuest:Jaha Nailah AveryHosts:Brandon CollinsThe Papa Dolble Recipe:Ingredients: 2 oz white rum ¾ oz fresh grapefruit juice ½ oz fresh lime juice ½ oz maraschino liqueur Shake with ice, strain into a coupe, and garnish with a lime wheel."Drunk Black History" is a production of Casa de Collins LLC.

Justin, Jaha, and Cory discuss Trump Derangement Syndrome and how it's affected their family and friends. They also talk about Michael Lind's article on how Trump has remade conservatism and political tribes.   Show Notes: https://www.wsj.com/opinion/is-trump-derangement-syndrome-real-a603e4a1?st=15Vz4N&reflink=desktopwebshare_permalink   https://unherd.com/2025/11/how-trump-remade-conservatism/   https://yourpoliticaltribe.com/ Learn more about your ad choices. Visit podcastchoices.com/adchoices

STILPODDEN 2026!!!! Vad har man på sig för att fånga en ”stabil kille” (Anton och Johan tycker till!). Vilka vinterskor gäller? Och till vilka byxor? Och varför ska Hanna aldrig mer visa brösten?

Justin, Jaha, and Cory discuss the government shutdown and which side is winning. They also talk about the role of economics in politics and Marjorie Taylor Greene's problem with the Republican Party.Show Notes: https://abcnews.go.com/Politics/bad-night-democrats-face-blowback-party-shutdown-deal/story?id=127379532 https://www.theamericansaga.com/p/the-2025-election-proves-that-the?utm_campaign=post&utm_medium=web https://thehill.com/homenews/house/5600663-mtg-greene-trump-health-care-syria/ Learn more about your ad choices. Visit podcastchoices.com/adchoices

Dr Sharonne Hayes, Professor of cardiovascular medicine and founding director of Mayo Clinic women's heart clinic, and Dr. Marysia Tweet, Associate Professor of cardiovascular medicine, and co-leader of the Spontaneous Coronary Artery Dissection Registry and leader in women's heart health join the show for this amazing November chapter of Always on EM. They are world experts on Spontaneous Coronary Artery Dissection authoring over 60 peer reviewed articles on the topic and in this chapter we explore with them the pitfalls and pearls related to making this diagnosis in the ED. SCAD is an important cause of myocardial infarction especially in patients who would not otherwise seem to be at risk for heart attacks for example active young women without comorbidities, and its imperitive that we as emergency physicians are current on this diagnosis.   DONATE TO DR JIM GREGOIRE SCHOLARSHIP FUND To honor the life of Dr. Jim Gregoire, dear friend of this show, consider donating to his scholarship fund. Go to https://give.mayoclinic.org/give/616870/#!/donation/checkout Go to: What would you like your donation to support? Choose “other” Enter: James Gregoire Scholarship Fund   CONTACTS X - @AlwaysOnEM; @VenkBellamkonda; @Marysia_Tweet; @SharonneHayes YouTube - @AlwaysOnEM; @VenkBellamkonda Instagram – @AlwaysOnEM; @Venk_like_vancomycin; @ASFinch; @SharonneHayes Email - AlwaysOnEM@gmail.com   DO YOU HAVE SCAD? DOES YOUR PATIENT HAVE SCAD? WANT TO GET CONNECTED? SCAD Research: www.scadresearch.org National Coalition for Women with Heart Disease: www.womenheart.org Mayo Clinic Womens Heart clinic: https://www.mayoclinic.org/departments-centers/womens-heart-clinic/overview/ovc-20442061   REFERENCES & LINKS Saleh G, Al-Abcha A, Chaaban K, Adi MZ, Tweet M, Collins JD, Alkhouli M, Gulati R. Concomitant Takotsubo Cardiomyopathy and Spontaneous Coronary Artery Dissection: Exploring the Role of Cardiac Mechanics on Coronary Disruption. JACC Cardiovasc Imaging. 2025 Oct;18(10):1161-1166. doi: 10.1016/j.jcmg.2025.05.020. Epub 2025 Aug 5. PMID: 40758075. Baqal O, Karikalan SA, Hasabo EA, Tareen H, Futela P, Qasba RK, Shafqat A, Qasba RK, Hayes SN, Tweet MS, El Masry HZ, Lee KS, Shen WK, Sorajja D. In- hospital and long-term outcomes in spontaneous coronary artery dissection with concurrent cardiac arrest: Systematic review and meta-analysis. Heart Rhythm O2. 2025 Apr 24;6(6):843-853. doi: 10.1016/j.hroo.2025.03.023. PMID: 40717849; PMCID: PMC12287955. Morosato M, Gaspardone C, Romagnolo D, Pagnesi M, Baldetti L, Dormio S, Federico F, Scandroglio AM, Chieffo A, Godino C, Margonato A, Adamo M, Metra M, Tchetche D, Dumonteil N, Tweet MS, Saw J, Beneduce A. Left Main Spontaneous Coronary Artery Dissection: Clinical Features, Management, and Outcomes. JACC Cardiovasc Interv. 2025 Apr 28;18(8):975-983. doi: 10.1016/j.jcin.2025.01.427. Epub 2025 Apr 9. PMID: 40208153; PMCID: PMC12290918. Tweet MS, Pellikka PA, Gulati R, Gochanour BR, Barrett-O'Keefe Z, Raphael CE, Best PJM, Hayes SN. Coronary Artery Tortuosity and Spontaneous Coronary Artery Dissection: Association With Echocardiography and Global Longitudinal Strain, Fibromuscular Dysplasia, and Outcomes. J Am Soc Echocardiogr. 2024 May;37(5):518-529. doi: 10.1016/j.echo.2024.02.013. Epub 2024 Mar 11. PMID: 38467311; PMCID: PMC11605948. Tweet MS, Hayes SN, Grimaldo ABG, Rose CH. Pregnancy After Spontaneous Coronary Artery Dissection: Counseling Patients Who Intend Future Pregnancy. JACC Adv. 2023 Dec;2(10):100714. doi: 10.1016/j.jacadv.2023.100714. Epub 2023 Nov 14. PMID: 38915307; PMCID: PMC11194843. Tarabochia AD, Tan NY, Lewis BR, Slusser JP, Hayes SN, Best PJM, Gulati R, Deshmukh AJ, Tweet MS. Association of Spontaneous Coronary Artery Dissection With Atrial Arrhythmias. Am J Cardiol. 2023 Jan 1;186:203-208. doi: 10.1016/j.amjcard.2022.09.032. Epub 2022 Oct 31. PMID: 36328832; PMCID: PMC10403149. Murugiah K, Chen L, Dreyer RP, Bouras G, Safdar B, Lu Y, Spatz ES, Gupta A, Khera R, Ng VG, Bueno H, Tweet MS, Spertus JA, Hayes SN, Lansky A, Krumholz HM. Depression and Perceived Stress After Spontaneous Coronary Artery Dissection and Comparison With Other Acute Myocardial Infarction (the VIRGO Experience). Am J Cardiol. 2022 Jun 15;173:33-38. doi: 10.1016/j.amjcard.2022.03.005. Epub 2022 Mar 29. PMID: 35365290; PMCID: PMC9133198. Johnson AK, Tweet MS, Rouleau SG, Sadosty AT, Hayes SN, Raukar NP. The presentation of spontaneous coronary artery dissection in the emergency department: Signs and symptoms in an unsuspecting population. Acad Emerg Med. 2022 Apr;29(4):423-428. doi: 10.1111/acem.14426. Epub 2021 Dec 26. PMID: 34897898; PMCID: PMC10403148. Murugiah K, Chen L, Dreyer RP, Bouras G, Safdar B, Khera R, Lu Y, Spatz ES, Ng VG, Gupta A, Bueno H, Tweet MS, Spertus JA, Hayes SN, Lansky A, Krumholz HM. Health status outcomes after spontaneous coronary artery dissection and comparison with other acute myocardial infarction: The VIRGO experience. PLoS One. 2022 Mar 23;17(3):e0265624. doi: 10.1371/journal.pone.0265624. PMID: 35320296; PMCID: PMC8942215. Adlam D, Tweet MS, Gulati R, Kotecha D, Rao P, Moss AJ, Hayes SN. Spontaneous Coronary Artery Dissection: Pitfalls of Angiographic Diagnosis and an Approach to Ambiguous Cases. JACC Cardiovasc Interv. 2021 Aug 23;14(16):1743-1756. doi: 10.1016/j.jcin.2021.06.027. PMID: 34412792; PMCID: PMC8383825. Kok SN, Tweet MS. Recurrent spontaneous coronary artery dissection. Expert Rev Cardiovasc Ther. 2021 Mar;19(3):201-210. doi: 10.1080/14779072.2021.1877538. Epub 2021 Feb 26. PMID: 33455483. Campbell KH, Tweet MS. Coronary Disease in Pregnancy: Myocardial Infarction and Spontaneous Coronary Artery Dissection. Clin Obstet Gynecol. 2020 Dec;63(4):852-867. doi: 10.1097/GRF.0000000000000558. PMID: 32701519; PMCID: PMC10767871. Tweet MS, Young KA, Best PJM, Hyun M, Gulati R, Rose CH, Hayes SN. Association of Pregnancy With Recurrence of Spontaneous Coronary Artery Dissection Among Women With Prior Coronary Artery Dissection. JAMA Netw Open. 2020 Sep 1;3(9):e2018170. doi: 10.1001/jamanetworkopen.2020. PMID: 32965500; PMCID: PMC7512056. Hayes SN, Tweet MS, Adlam D, Kim ESH, Gulati R, Price JE, Rose CH. Spontaneous Coronary Artery Dissection: JACC State-of-the-Art Review. J Am Coll Cardiol. 2020 Aug 25;76(8):961-984. doi: 10.1016/j.jacc.2020.05.084. PMID: 32819471. Johnson AK, Hayes SN, Sawchuk C, Johnson MP, Best PJ, Gulati R, Tweet MS. Analysis of Posttraumatic Stress Disorder, Depression, Anxiety, and Resiliency Within the Unique Population of Spontaneous Coronary Artery Dissection Survivors. J Am Heart Assoc. 2020 May 5;9(9):e014372. doi: 10.1161/JAHA.119.014372. Epub 2020 Apr 28. PMID: 32342736; PMCID: PMC7428589. Tweet MS, Akhtar NJ, Hayes SN, Best PJ, Gulati R, Araoz PA. Spontaneous coronary artery dissection: Acute findings on coronary computed tomography angiography. Eur Heart J Acute Cardiovasc Care. 2019 Aug;8(5):467-475. doi: 10.1177/2048872617753799. Epub 2018 Jan 29. PMID: 29376398; PMCID: PMC6027604. Tan NY, Tweet MS. Spontaneous coronary artery dissection: etiology and recurrence. Expert Rev Cardiovasc Ther. 2019 Jul;17(7):497-510. doi: 10.1080/14779072.2019.1635011. Epub 2019 Jul 5. PMID: 31232618. Waterbury TM, Tweet MS, Hayes SN, Eleid MF, Bell MR, Lerman A, Singh M, Best PJM, Lewis BR, Rihal CS, Gersh BJ, Gulati R. Early Natural History of Spontaneous Coronary Artery Dissection. Circ Cardiovasc Interv. 2018 Sep;11(9):e006772. doi: 10.1161/CIRCINTERVENTIONS.118. PMID: 30354594. Hayes SN, Kim ESH, Saw J, Adlam D, Arslanian-Engoren C, Economy KE, Ganesh SK, Gulati R, Lindsay ME, Mieres JH, Naderi S, Shah S, Thaler DE, Tweet MS, Wood MJ; American Heart Association Council on Peripheral Vascular Disease; Council on Clinical Cardiology; Council on Cardiovascular and Stroke Nursing; Council on Genomic and Precision Medicine; and Stroke Council. Spontaneous Coronary Artery Dissection: Current State of the Science: A Scientific Statement From the American Heart Association. Circulation. 2018 May 8;137(19):e523-e557. doi: 10.1161/CIR.0000000000000564. Epub 2018 Feb 22. PMID: 29472380; PMCID: PMC5957087. Tweet MS, Kok SN, Hayes SN. Spontaneous coronary artery dissection in women: What is known and what is yet to be understood. Clin Cardiol. 2018 Feb;41(2):203-210. doi: 10.1002/clc.22909. Epub 2018 Mar 1. PMID: 29493808; PMCID: PMC5953427. Tweet MS, Codsi E, Best PJM, Gulati R, Rose CH, Hayes SN. Menstrual Chest Pain in Women With History of Spontaneous Coronary Artery Dissection. J Am Coll Cardiol. 2017 Oct 31;70(18):2308-2309. doi: 10.1016/j.jacc.2017.08.071. PMID: 29073960; PMCID: PMC5957076. Lindor RA, Tweet MS, Goyal KA, Lohse CM, Gulati R, Hayes SN, Sadosty AT. Emergency Department Presentation of Patients with Spontaneous Coronary Artery Dissection. J Emerg Med. 2017 Mar;52(3):286-291. doi: 10.1016/j.jemermed.2016.09. Epub 2016 Oct 8. PMID: 27727035. Tweet MS, Gulati R, Williamson EE, Vrtiska TJ, Hayes SN. Multimodality Imaging for Spontaneous Coronary Artery Dissection in Women. JACC Cardiovasc Imaging. 2016 Apr;9(4):436-50. doi: 10.1016/j.jcmg.2016.01.009. PMID: 27056163. Tweet MS, Gulati R, Hayes SN. What Clinicians Should Know Αbout Spontaneous Coronary Artery Dissection. Mayo Clin Proc. 2015 Aug;90(8):1125-30. doi: 10.1016/j.mayocp.2015.05.010. PMID: 26250728. Prasad M, Tweet MS, Hayes SN, Leng S, Liang JJ, Eleid MF, Gulati R, Vrtiska TJ. Prevalence of extracoronary vascular abnormalities and fibromuscular dysplasia in patients with spontaneous coronary artery dissection. Am J Cardiol. 2015 Jun 15;115(12):1672-7. doi: 10.1016/j.amjcard.2015.03.011. Epub 2015 Mar 23. PMID: 25929580. Goel K, Tweet M, Olson TM, Maleszewski JJ, Gulati R, Hayes SN. Familial spontaneous coronary artery dissection: evidence for genetic susceptibility. JAMA Intern Med. 2015 May;175(5):821-6. doi: 10.1001/jamainternmed.2014. PMID: 25798899. Liang JJ, Prasad M, Tweet MS, Hayes SN, Gulati R, Breen JF, Leng S, Vrtiska TJ. A novel application of CT angiography to detect extracoronary vascular abnormalities in patients with spontaneous coronary artery dissection. J Cardiovasc Comput Tomogr. 2014 May-Jun;8(3):189-97. doi: 10.1016/j.jcct.2014.02.001. Epub 2014 Apr 4. PMID: 24939067. Tweet MS, Hayes SN, Pitta SR, Simari RD, Lerman A, Lennon RJ, Gersh BJ, Khambatta S, Best PJ, Rihal CS, Gulati R. Clinical features, management, and prognosis of spontaneous coronary artery dissection. Circulation. 2012 Jul 31;126(5):579-88. doi: 10.1161/CIRCULATIONAHA.112. Epub 2012 Jul 16. PMID: 22800851. Tweet MS, Gulati R, Aase LA, Hayes SN. Spontaneous coronary artery dissection: a disease-specific, social networking community-initiated study. Mayo Clin Proc. 2011 Sep;86(9):845-50. doi: 10.4065/mcp.2011.0312. PMID: 21878595; PMCID: PMC3257995.   WANT TO WORK AT MAYO? EM Physicians: https://jobs.mayoclinic.org/emergencymedicine EM NP PAs: https://jobs.mayoclinic.org/em-nppa-jobs   Nursing/Techs/PAC: https://jobs.mayoclinic.org/Nursing-Emergency-Medicine EMTs/Paramedics: https://jobs.mayoclinic.org/ambulanceservice All groups above combined into one link: https://jobs.mayoclinic.org/EM-Jobs

With Sotiria Liori, Attikon University Hospital, National and Kapodistrian University of Athens - Greece and Julie De Backer, Ghent University Hospital - Belgium. In this episode, Sotiria Liori and Julie De Backer discuss heart failure in adult congenital heart disease patients — covering how congenital lesions and prior repairs shape epidemiology and mechanisms (ventricular remodeling, valvular and conduit dysfunction, arrhythmias), as well as clinical assessment with imaging, biomarkers, and hemodynamics. They outline management with guideline-directed therapy, rhythm considerations, indications for advanced therapies (MCS and transplant), and pregnancy counseling. The episode also highlights multidisciplinary care models and key evidence gaps. Proposed reading:  General Principles of Heart Failure Management in Adult Congenital Heart Disease. Tompkins R, Romfh A. Heart Failure Reviews. 2020;25(4):555-567. doi:10.1007/s10741-019-09895-x Chronic Heart Failure in Congenital Heart Disease: A Scientific Statement From the American Heart Association. Stout KK, Broberg CS, Book WM, et al. Circulation. 2016;133(8):770-801. doi:10.1161/CIR.0000000000000352. Relation Between New York Heart Association Functional Class and Objective Measures of Cardiopulmonary Exercise in Adults With Congenital Heart Disease. Das BB, Young ML, Niu J, et al. The American Journal of Cardiology. 2019;123(11):1868-1873. doi:10.1016/j.amjcard.2019.02.053.  Heart Failure and Patient-Reported Outcomes in Adults With Congenital Heart Disease from 15 Countries. Lu CW, Wang JK, Yang HL, Kovacs AH, et al; APPROACH‐IS consortium, the International Society for Adult Congenital Heart Disease (ISACHD) *.J Am Heart Assoc. 2022 May 3;11(9):e024993. doi: 10.1161/JAHA.121.024993. Epub 2022 Apr 26. Pharmacological Therapy in Adult Congenital Heart Disease: Growing Need, Yet Limited Evidence. Brida M, Diller GP, Nashat H, et al. European Heart Journal. 2019;40(13):1049-1056. doi:10.1093/eurheartj/ehy480. Advanced Heart Failure Therapies For Adults With Congenital Heart Disease: JACC State-of-the-Art Review. Givertz MM, DeFilippis EM, Landzberg MJ, et al. Journal of the American College of Cardiology. 2019;74(18):2295-2312.doi:10.1016/j.jacc.2019.09.004. A Review of Heart Transplantation for Adults With Congenital Heart Disease. McMahon A, McNamara J, Griffin M. Journal of Cardiothoracic and Vascular Anesthesia. 2021;35(3):752-762. doi:10.1053/j.jvca.2020.07.027. Heart Failure in Adult Congenital Heart Disease: From Advanced Therapies to End-of-Life Care. Crossland DS, Van De Bruaene A, Silversides CK, Hickey EJ, Roche SL. The Canadian Journal of Cardiology. 2019;35(12):1723-1739. doi:10.1016/j.cjca.2019.07.626. This 2025 HFA Cardio Talk podcast series is supported by Bayer AG in the form of an unrestricted financial support. The discussion has not been influenced in any way by its sponsor. 

This week we review an episode from 3 years back and delve into the world of adult congenital heart disease when we review a recent work from the ACHD team at UCSF that assesses the impact of BMI on clinical outcomes in the single ventricle adult Fontan patient. What is the cause of elevation in BMI in some Fontan patients? Is obesity the only explanation? Is BMI a modifiable risk factor for our Fontan patients and should exercise be 'prescribed' for these patients? If so prescribed, what type of exercise is best for the Fontan patient? This week's work's senior author, Dr. Anushree Agarwal, Assistant Professor of Medicine at UCSF, shares her insights into this important topic. DOI: 10.1161/JAHA.122.026732Also mentioned in today's episode is episode #222 with Dr. Dan Halpern of NYU medical center (https://www.stitcher.com/show/pediheartpediatric-cardiology-today/episode/pediheart-podcast-222-impact-of-cardiac-rehab-on-exercise-tolerance-in-the-achd-patient-206781483)

Justin, Jaha, and Hannah discuss David Brooks' article about red states outpacing blue states in education. They also discuss James Talarico and Trump's Gaza deal.Show Notes: https://www.nytimes.com/2025/10/09/opinion/democrats-education-failure.html?smid=nytcore-ios-share&referringSource=articleShare https://www.politico.com/news/2025/08/21/james-talarico-miriam-adelson-billionaire-donations-00517288 https://www.bbc.com/news/articles/cj3yke64vp6o Learn more about your ad choices. Visit podcastchoices.com/adchoices

Justin and Jaha talk about Dr. Alan Noble's article on a post-literate culture and how that impacts Christian discernment. They also discuss Gaza and how AI data centers are raising energy costs for Americans.   Show Notes: What Does a Post-Literate Culture Look Like?  https://www.bloomberg.com/graphics/2025-ai-data-centers-electricity-prices/ https://www.cnn.com/world/live-news/israel-gaza-hamas-trump-10-05-25 Learn more about your ad choices. Visit podcastchoices.com/adchoices

In this compelling episode of Vital Voices Live, Gambian women's rights activist Jaha Dukureh — a leading campaigner against female genital mutilation, founder and executive director of Safe Hands for Girls, TIME 100 honoree, and Nobel Peace Prize nominee — joins acclaimed actor and New York Times bestselling author Ashley Judd. Interviewed by actor and CARE Ambassador Bellamy Young, they explore the global fight to end female genital mutilation, the ongoing evolution of the #MeToo movement in Hollywood, and the power of personal stories to spark change for women and girls worldwide.

Justin, Jaha, and Cory discuss the importance of taking unpopular positions when principles are at stake. They also talk about the Jimmy Kimmel debacle and shout out Memphis Mayor Paul Young. Show Notes: https://www.nbcnews.com/politics/congress/rand-paul-fcc-chair-comments-absolutely-inappropriate-jimmy-kimmel-rcna232703 https://youtu.be/u3IGa1mrCKQ Learn more about your ad choices. Visit podcastchoices.com/adchoices

Justin, Cory, and Jaha discuss reactions to the assassination of Charlie Kirk. They also talk about a Christlike path forward.   Show Notes: https://www.nytimes.com/2025/09/14/opinion/charlie-kirk-assassination-ideology.html Learn more about your ad choices. Visit podcastchoices.com/adchoices

Today, Sam, Ryan, and Tyler talk about the mysterious city of Jaha! Join them as they talk about the city's strange origins, their relationship with the stars, and why you should make sure you stock up on coffee before visiting! Continuing the exploration of Golarion, the Campaign Setting for the Pathfinder Roleplaying Game by Paizo Inc. Website: TabletopTravelGuide.com   Email: TabletopTravelGuidePodcast@gmail.com     Instagram: @TabletopTravelGuide Patreon: Tabletop Travel Guide Podcast Theme Music By: Raymond Gramke

Jaha, är det inte ljudet så är det uppkopplingen. I veckans avsnitt introducerar vi lite fasta punkter som vi tänkt ska bli återkommande. Dessutom laggar Jörgens ADSL. Vi pratar också jakt och Tomas avslöjar att han jobbar extra som barista ute i skogen. Välkommen att lyssna.

In this special episode on Strategies for Staying Full and Satisfied, our host, Dr. Neil Skolnik will moderate a discussion with Lily Correa, registered dietitian about communicating strategies for staying full and satisfied. This special edition of Diabetes Core Update is sponsored by Avocados - Love One Today ®.    For more information, as well as diabetes-friendly mean plans and a free downloadable toolkit just go to:http://loveonetoday.com/SatisfiedEating Presented by: Neil Skolnik, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Associate Director, Family Medicine Residency Program, Abington Jefferson Health Lilian (Lily) M. Correa, Lily Correa is a registered dietitian and diplomate of the American College of Lifestyle Medicine   Resources and References:   Henning, Susanne M. et al. Hass Avocado Inclusion in a Weight-Loss Diet Supported Weight Loss and Altered Gut Microbiota: A 12-Week Randomized, Parallel-Controlled Trial. Current Developments in Nutrition 2019, Volume 3, Issue 8, ISSN 2475-2991. https://doi.org/10.1093/cdn/nzz068.   Khan, Naiman A. et al. Avocado Consumption, Abdominal Adiposity, and Oral Glucose Tolerance Among Persons with Overweight and Obesity. The Journal of Nutrition 2021, Volume 151, Issue 9p2513-2521. https://doi.org/10.1093/jn/nxab187.   Lichtenstein, Alice H. et al. Effect of Incorporating 1 Avocado Per Day Versus Habitual Diet on Visceral Adiposity: A Randomized Trial. Journal of the American Heart Association 2022, Volume 11, Number 14. https://doi.org/10.1161/JAHA.122.02565.   Pacheco, Lorena S. et al. Effects of Different Allotments of Avocados on the Nutritional Status of Families: A Cluster Randomized Controlled Trial. Nutrients 2021, 13(11), 4021. https://doi.org/10.3390/nu13114021.   Senn, MacKenzie K. et al. Associations between avocado intake and measures of glucose and insulin homeostasis in Hispanic individuals with and without type 2 diabetes: Results from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). Nutrition, Metabolism and Cardiovascular Diseases 2023, Volume 33, Issue 12, 2428 – 2439. https://doi.org/10.1016/j.numecd.2023.08.002.   Wood, Alexis C. et al. Associations between Metabolomic Biomarkers of Avocado Intake and Glycemia in the Multi-Ethnic Study of Atherosclerosis. The Journal of Nutrition 2023, Volume 153, Issue 10, 2797 – 2807. https://doi.org/10.1016/j.tjnut.2023.07.013.   For more resources, research and recipes visit LoveOneToday.com/healthprofessionals.

Vidcast:  https://www.instagram.com/p/DN023UfWjJq/So-called “clear e-cigarettes that contain synthetic cooling agents trigger greater blood pressure and heart rate increases than menthol flavored e-cigarettes.  Yale and Boston University researchers issue this warning following their study of 200 young adult vapers and non-vapers.  They analyzed 3 groups: 23 clear-ecig vapers; 111 non-clear vapers; and 73 non-vapers. Their paper appears in the Journal of the American Heart Association.These “clear” vapes contain WS-23 or WS-3, both synthetic coolants that mimic menthol's cooling effects but impart no flavor to the vapor. The data revealed that these agents were associated with greater heart strains than e-cigs containing menthol itself. The investigators suggest that these synthetic cooling agents have been introduced to circumvent bans against flavorings in vaping products, such as the ones in Massachusetts, California, New York State, Delaware, and elect cities around the country,.While this study only looked at the short term effects of these synthetic cooling agents, it's not unreasonable to believe that “clear” e-cigs create greater risks of heart failure and stroke over time than other e-cigs. As usual..buyer beware.https://medicalxpress.com/news/2025-08-cigarettes-linked-greater-acute-blood.htmlhttps://www.ahajournals.org/doi/10.1161/JAHA.124.036106#ecigarettes #vaping #clear #cooling #menthol #hypertension #heartfailure #stroke 

John Mandrola discusses conduction system pacing vs standard pacing, withdrawing HF meds when AF is corrected and patient selection in LAAO. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I Conduction System Pacing CSPACE trial https://doi.org/10.1016/j.jacc.2025.06.043 BLOCK HF trial https://www.nejm.org/doi/full/10.1056/NEJMoa1210356 BioPace trial https://doi.org/10.1093/europace/euaf029 II  Withdrawing Meds After AF Corrected WITHDRAW AF https://doi.org/10.1093/eurheartj/ehaf563 TRED HF https://pubmed.ncbi.nlm.nih.gov/30429050/ III Patient Selection in Left Atrial Appendage Occlusion Long-Term Outcomes Following LAAO in Medicare Beneficiaries: Outcomes From the National Cardiovascular Data Registry https://www.ahajournals.org/doi/10.1161/JAHA.124.039780 ESC Preview IV HTN Guidelines New Blood Pressure Guidelines: 4 Things I Like and 2 Concerns https://www.medscape.com/viewarticle/new-blood-pressure-guidelines-4-thing-i-and-2-concerns-2025a1000m1x You may also like: The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net

Justin, Jaha, and Cory discuss the pressure people are under to act more progressive in academia and professional class circles. They also discuss mandatory mental health screenings for kids and Meta chatbots flirting with children.   Show Notes:  https://thehill.com/opinion/education/5446702-performative-virtue-signaling-has-become-a-threat-to-higher-ed/ https://www.cbsnews.com/chicago/news/gov-pritzker-signs-requiring-mental-health-screenings-schools/ https://www.thefp.com/p/abigail-shrier-stop-asking-kids-if https://mchb.hrsa.gov/sites/default/files/mchb/data-research/nsch-data-brief-adolescent-mental-behavioral-health-2023.pdf   Learn more about your ad choices. Visit podcastchoices.com/adchoices

Just talks to Cory and Jaha about eight political tribes in the American electorate. They also discuss Michael Wear's new article in UnHerd and Charlie Kirk's answer to a question about Trump and the fruit of the spirit. ShowNotes:https://echeloninsights.com/tribes/https://hiddentribes.us/https://unherd.com/2025/07/will-democrats-defend-society/?lang=ushttps://x.com/aprilspark1890/status/1950278328184619011?s=46&t=QIXD2eZx9xXe5eDxKKUDPg Learn more about your ad choices. Visit podcastchoices.com/adchoices

In this Mission Matters episode, Adam Torres interviews Jaha Cummings, Founder of the Blanchard House Institute, on how his work blends economic revitalization, cultural preservation, and storytelling. Through initiatives like the American Dream Fund and Storyboard USA, Jaha empowers underinvested communities to reclaim their history and reshape their futures. This interview is part of the Milken Global Conference coverage by Mission Matters. Big thanks to the ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Milken Institute⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ for inviting us to cover the conference. Follow Adam on Instagram at ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.instagram.com/askadamtorres/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ for up to date information on book releases and tour schedule. Apply to be a guest on our podcast: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://missionmatters.lpages.co/podcastguest/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Visit our website: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://missionmatters.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠More FREE content from Mission Matters here: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://linktr.ee/missionmattersmedia Learn more about your ad choices. Visit podcastchoices.com/adchoices

Approval of first-generation devices, the ticagrelor controversy, ICD longevity, the PRAGUE-25 trial (one of the most important trials of the year), and some thoughts on the end of EP as a profession are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I More Ticagrelor Controversy BMJ Investigation Finds More Concerns in Ticagrelor Trials https://www.medscape.com/viewarticle/investigation-bmj-raises-more-concerns-about-ticagrelor-2025a1000gh3 Ticagrelor PLATO study https://www.bmj.com/content/389/bmj.r1201 Ticagrelor vs Clopidogrel https://www.nejm.org/doi/full/10.1056/NEJMoa0904327 Review of the Ticagrelor Trials Evidence Base https://www.ahajournals.org/doi/10.1161/JAHA.123.031606 The Plato Trial: Do you believe in magic? https://doi.org/10.1093/eurheartj/ehp545 ONSET/OFFSET Antiplatelet Effects https://www.ahajournals.org/doi/10.1161/circulationaha.109.912550 RESPOND Study https://www.ahajournals.org/doi/10.1161/circulationaha.109.919456 II ICD Battery Longevity Variability in ICD Battery Longevity https://doi.org/10.1016/j.hrthm.2025.05.031 PRAGUE-25 Trial of AF Ablation vs LFM PRAGUE-25 Trial https://www.jacc.org/doi/10.1016/j.jacc.2025.04.042 You may also like: The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net

FDA approves triple-drug polypill, a change of opinion, a deep dive into invasive pulmonary embolism therapies, heart disease trends, and diabetes care is on fire are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I FDA News in HTN FDA announcement https://george-medicines.com/george-medicines-announces-fda-approval-of-widaplik-telmisartan-amlodipine-and-indapamide-a-new-single-pill-combination-treatment-for-hypertension-in-adults-including-initial-treatment/ Lancet Study https://doi.org/10.1016/S0140-6736(24)01744-6 JACC study vs placebo https://www.jacc.org/doi/abs/10.1016/j.jacc.2024.08.025 JAMA Cardiology Meta-analysis https://jamanetwork.com/journals/jamacardiology/fullarticle/2804313 II Invasive PE Therapy EHJ-Open review: https://academic.oup.com/ehjopen/article/5/3/oeaf071/8156689 PEITHO Trial https://www.nejm.org/doi/10.1056/NEJMoa1302097 REAL PE Observational Study https://pmc.ncbi.nlm.nih.gov/articles/PMC11308131/ III Heart Disease Trends King et al https://www.ahajournals.org/doi/10.1161/JAHA.124.038644 IV Diabetes Coverage Medscape Link https://www.medscape.com/viewcollection/37830 You may also like: The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net

In this raw and riveting episode of People, Alpha Warrior sits down with actor, director, and cultural firebrand Isaiah Washington for an unfiltered look at a life shaped by trauma, triumph, and tenacity. From growing up poor in Houston without knowing it, to walking away from Hollywood deals with his integrity intact, Isaiah shares the unvarnished truth behind the headlines. He recounts his mother's resilience, the early days of navigating identity and poverty, and the moment he reclaimed his legacy through roles like Bass Reeves in Corsicana and Jaha in The 100. The conversation dives deep into race, representation, faith, censorship, and the manipulation of narrative in media and politics. Isaiah reflects on his time in the military, the shadowy workings of Hollywood, and the spiritual war behind the scenes. With stunning vulnerability and sharp wisdom, he calls for a return to legacy over success, truth over applause, and God over algorithms. This isn't a celebrity interview, it's a masterclass in resilience, redemption, and living on purpose. If you think you know Isaiah Washington, think again. This is the man behind the camera, behind the controversy, and behind the mission.

AI and ECGs, novel ways to treat hypertension, combined lipid-lowering therapy after myocardial infarction, PFA and silent stroke, a move toward accountability in AF ablation, and pacing issues in TTVR are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I Help with ECGs in the ED AI Shows Promise for Rapid NSTEMI Diagnosis https://www.medscape.com/viewarticle/ai-shows-promise-rapid-nstemi-diagnosis-2025a10009pw Buscher et al https://doi.org/10.1093/eurheartj/ehaf254 II A Novel way to Treat HTN A Pacemaker to Control BP Gets FDA Breakthrough Designation https://www.medscape.com/viewarticle/pacemaker-control-bp-gets-fda-breakthrough-designation-2025a10009t3 JAHA paper https://www.ahajournals.org/doi/10.1161/JAHA.120.020492 Backbeat https://clinicaltrials.gov/study/NCT06059638 III Type of PFA may matter for Silent Cerebral Lesions Paper https://www.ahajournals.org/doi/10.1161/CIRCEP.125.013719 IV Accountability coming to US AF ablation Heart Rhythm Society Releases a Document on Establishing Centers of Excellence for AF ablation -- Press Release https://www.hrsonline.org/news/new-white-paper-on-atrial-fibrillation-centers-of-excellence/ V Pacing in Patients with Undergoing Transcatheter Tricuspid Valve Replacement Paper https://doi.org/10.1016/j.hrthm.2025.02.004 You may also like: The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net

Credits: 0.25 AMA PRA Category 1 Credit™   CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-428 Overview: Stay ahead in stroke prevention with the latest guidelines. In this episode, we cover new considerations for social determinants of health, interventions across the lifespan, and evidence-based strategies to reduce stroke risk. Learn how to integrate these updates into primary care for more effective patient outcomes. Episode resource links: Bushnell, C., Kernan, W. N., Sharrief, A. Z., Chaturvedi, S., Cole, J. W., Cornwell, W. K., 3rd, Cosby-Gaither, C., Doyle, S., Goldstein, L. B., Lennon, O., Levine, D. A., Love, M., Miller, E., Nguyen-Huynh, M., Rasmussen-Winkler, J., Rexrode, K. M., Rosendale, N., Sarma, S., Shimbo, D., Simpkins, A. N., … Whelton, P. K. (2024). 2024 Guideline for the Primary Prevention of Stroke: A Guideline From the American Heart Association/American Stroke Association. Stroke, 55(12), e344–e424. https://doi.org/10.1161/STR.0000000000000475 Ravichandran, S., Gajjar, P., Walker, M. E., Prescott, B., Tsao, C. W., Jha, M., Rao, P., Miller, P., Larson, M. G., Vasan, R. S., Shah, R. V., Xanthakis, V., Lewis, G. D., & Nayor, M. (2024). Life's Essential 8 Cardiovascular Health Score and Cardiorespiratory Fitness in the Community. Journal of the American Heart Association, 13(9), e032944. https://doi.org/10.1161/JAHA.123.032944 Kumar, M., Orkaby, A., Tighe, C., Villareal, D. T., Billingsley, H., Nanna, M. G., Kwak, M. J., Rohant, N., Patel, S., Goyal, P., Hummel, S., Al-Malouf, C., Kolimas, A., Krishnaswami, A., Rich, M. W., Kirkpatrick, J., Damluji, A. A., Kuchel, G. A., Forman, D. E., & Alexander, K. P. (2023). Life's Essential 8: Optimizing Health in Older Adults. JACC. Advances, 2(7), 100560. https://doi.org/10.1016/j.jacadv.2023.100560 Life's Essential 8 tools for providers and patient information: https://www.heart.org/en/healthy-living/healthy-lifestyle/lifes-essential-8 Guest: Jill M. Terrien PhD, ANP-BC   Music Credit: Matthew Bugos Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com   

Credits: 0.25 AMA PRA Category 1 Credit™   CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-428 Overview: Stay ahead in stroke prevention with the latest guidelines. In this episode, we cover new considerations for social determinants of health, interventions across the lifespan, and evidence-based strategies to reduce stroke risk. Learn how to integrate these updates into primary care for more effective patient outcomes. Episode resource links: Bushnell, C., Kernan, W. N., Sharrief, A. Z., Chaturvedi, S., Cole, J. W., Cornwell, W. K., 3rd, Cosby-Gaither, C., Doyle, S., Goldstein, L. B., Lennon, O., Levine, D. A., Love, M., Miller, E., Nguyen-Huynh, M., Rasmussen-Winkler, J., Rexrode, K. M., Rosendale, N., Sarma, S., Shimbo, D., Simpkins, A. N., … Whelton, P. K. (2024). 2024 Guideline for the Primary Prevention of Stroke: A Guideline From the American Heart Association/American Stroke Association. Stroke, 55(12), e344–e424. https://doi.org/10.1161/STR.0000000000000475 Ravichandran, S., Gajjar, P., Walker, M. E., Prescott, B., Tsao, C. W., Jha, M., Rao, P., Miller, P., Larson, M. G., Vasan, R. S., Shah, R. V., Xanthakis, V., Lewis, G. D., & Nayor, M. (2024). Life's Essential 8 Cardiovascular Health Score and Cardiorespiratory Fitness in the Community. Journal of the American Heart Association, 13(9), e032944. https://doi.org/10.1161/JAHA.123.032944 Kumar, M., Orkaby, A., Tighe, C., Villareal, D. T., Billingsley, H., Nanna, M. G., Kwak, M. J., Rohant, N., Patel, S., Goyal, P., Hummel, S., Al-Malouf, C., Kolimas, A., Krishnaswami, A., Rich, M. W., Kirkpatrick, J., Damluji, A. A., Kuchel, G. A., Forman, D. E., & Alexander, K. P. (2023). Life's Essential 8: Optimizing Health in Older Adults. JACC. Advances, 2(7), 100560. https://doi.org/10.1016/j.jacadv.2023.100560 Life's Essential 8 tools for providers and patient information: https://www.heart.org/en/healthy-living/healthy-lifestyle/lifes-essential-8 Guest: Jill M. Terrien PhD, ANP-BC   Music Credit: Matthew Bugos Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com   

150 - What If Your Brain Fog Isn't All In Your Head? 7 Fixes You've Never TriedIf you've ever walked into a room and immediately forgotten why you're there, you'll want to hear this. What if your brain fog isn't just a coffee shortage… but a mitochondrial meltdown? In this episode of the Pretty Well Podcast, we're digging into the real root of brain health—your mitochondria. Yep, those tiny powerhouses are pulling more weight than you think. You'll learn 7 simple, science-backed ways to boost your brain clarity, energy, and focus (without adding 42 more supplements to your cart). If you're dealing with forgetfulness, low energy, or feeling like your brain's operating on dial-up, this one's for you. We're talking longevity, cognitive vitality, and how to keep your brain as sharp as your wit. Think of it as a tune-up for your brain; real ways to support long-term cognitive health so you can stay sharp, focused, and actually remember where you put your keys.Links & Resources:Atorvastatin decreases the coenzyme Q10 level in the blood of patients at risk for cardiovascular disease and stroke; Arch Neurol. 2004;61(6):889-892. doi:10.1001/archneur.61.6.889https://jamanetwork.com/journals/jamaneurology/fullarticle/786017#google_vignetteEffects of Coenzyme Q10 on Statin‐Induced Myopathy: An Updated Meta‐Analysis of Randomized Controlled Trials; Journal of the American Heart AssociationVolume 7, Number 19 https://doi.org/10.1161/JAHA.118.009835 Amazon Links: *As An Amazon Associate I Earn A Small Commission From Qualifying Purchases At No Extra Cost To You*Pure Encapsulations Brand Mitochondria-Supporting Supplements:Magnesium Glycinate https://amzn.to/4iWlvhx Magnesium Citrate https://amzn.to/4ldRPy1 B complex Plus https://amzn.to/4lj1yTD B complex with PQQ and ALA https://amzn.to/4i3Kv54 CoQ 10 (active form Ubiquinol) https://amzn.to/4lisnHA Saccharomyces boulardii (probiotic) https://amzn.to/3DXc4zg Bellway Super Fiber: https://amzn.to/4i7Ud6B Nature's Sunshine Liquid Chlorophyll ES: https://amzn.to/42xQEly Epic Water Filter Products: https://amzn.to/42wOKSe Join the conversation: Share your thoughts with us on social media or in the comments!Subscribe, Share & Review: Remember to subscribe, share this episode, and leave a review. Your support helps us reach more women looking for answers.Disclaimer: Nothing in this podcast is to be taken as medical advice, please take informed accountability and speak to your provider before making changes to your health routine.The primary purpose of The Pretty Well Podcast being to educate. This content is for informational and educational purposes only. It is not intended to provide medical advice nor to take the place of such advice or treatment from a personal physician. By listening to this content, you agree to consult your own physician or qualified health professional regarding specific health questions. Neither Lisa Smith, The Pretty Well Podcast, nor any guest takes responsibility for possible health consequences of any person or persons following the information in this educational content. All listeners of this content, especially those who are pregnant or taking prescription or over-the-counter medications, should consult their physicians before beginning any nutrition, supplement, or lifestyle program. The Pretty Well Podcast is for private non-commercial use and our guests do not necessarily reflect any agency, organization, or company that they work for. In addition, opinions of interview guests do not necessarily reflect the opinions of Lisa Smith and/or The Pretty Well Podcast. This content is not guaranteed to be correct, complete, or up to date.If you tune into any of the following shows, you'll like ours too! The Dr. Josh Axe Show, Wellness Mama, Be Well By Kelly Leveque, The Freely Rooted Podcast with Kori Meloy, The Dr. Mark Hyman Show, Dr. Jockers Functional Nutrition

In this episode, we discuss the very early stages of drug targets and drug development with Dr. Mohd Shahid, PhD. Dr. Shahid's research involves the IER3 gene, which is an important modulator of the body's inflammatory response via its action in major immune cells, including macrophages and T-cells, and plays a role in metabolic disorders such as obesity, diabetes, and atherosclerosis, revealing a previously unknown function of this protein. Key Concepts Drug development is a multi-decade journey – human clinical trials occur very late in the process. Drug development often starts before a drug molecule is even conceived by identifying potential drug targets. Chronic inflammation is important for a variety of diseases, including obesity and atherosclerosis. Dr. Shahid's work focuses on a specific gene, Immediate Early Response 3 Gene (IER3 or IEX-1), and its role in modulating the inflammatory response in these disease states. The research process frequently leads to unexpected discoveries and new lines of inquiry. With Dr. Shahid, his work in obesity and inflammation actually led to a new understanding of the IER3's role in the interplay between macrophages, inflammation, and energy expenditure. References Shahid M, Javed AA, Chandra D, et al. IER3 deficiency induces browning of white adipose tissue and resists diet-induced obesity. Sci Rep. 2016;6:24135. Published 2016 Apr 11. doi:10.1038/srep24135 Shahid M, Hermes EL, Chandra D, et al. J Am Heart Assoc. 2018;7:e009261. DOI: 10.1161/JAHA.118.009261. Ridker PM, Danielson E, Fonseca FA, et al. Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein. N Engl J Med. 2008;359(21):2195-2207. doi:10.1056/NEJMoa0807646 Tardif JC, Kouz S, Waters DD, et al. Efficacy and Safety of Low-Dose Colchicine after Myocardial Infarction. N Engl J Med. 2019;381(26):2497-2505. doi:10.1056/NEJMoa1912388

The goal of CPR is to keep the brain and vital organs perfused until return of spontaneous circulation (ROSC) is achieved.Post-arrest care and recovery are the final two links in the chain of survival.Identification of ROSC during CPR.Initial patient management goals after identifying ROSC.The patient's GCS/LOC should be evaluated to determine if targeted temperature management (TTM) is indicated.Patients that cannot obey simple commands should receive TTM for at least 24 hours.Recently published studies on TTM and ACLS's current standard.Monitoring the patient's core temperature during TTM.Patients can undergo EEG, CT, MRI, & PCI while receiving TTM.Good luck with your ACLS class!Links: Buy Me a Coffee at https://buymeacoffee.com/paultaylor Practice ECG rhythms at Dialed Medics - https://dialedmedics.com/Safe Meds VIP - Learn about medication safety and download a free drug discount card to save money on prescription medications for you and your pets: https://safemeds.vipPass ACLS Web Site - Episode archives & other ACLS-related podcasts: https://passacls.com@Pass-ACLS-Podcast on LinkedIn No statistical diff (TTM2 summary): https://www.ahajournals.org/doi/10.1161/JAHA.122.026539

Stopping oral anticoagulation after AF ablation, the core problem with paradoxes like the smoker's paradox, chronic total occlusion PCI, and an ACC/EHRA preview are discussed by John Mandrola, MD, in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I Oral Anticoagulation after Successful AF Ablation Iwawakie et al https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2831851 OCEAN protocol paper https://doi.org/10.1016/j.ahj.2017.12.007 II Smoker's Paradox Presch et al https://www.jacc.org/doi/10.1016/j.jcin.2024.12.028 Gupta et al https://doi.org/10.1161/JAHA.116.003370 III CTO PCI Main sub-analysis paper Bangalore et al https://doi.org/10.1016/j.jacc.2025.01.029 DECISION CTO https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.118.031313 Main EURO CTO trial https://doi.org/10.1093/eurheartj/ehy220 3-year MACE of EURO CTO https://eurointervention.pcronline.com/article/three-year-outcomes-of-eurocto-a-randomized-multicentre-trial-comparing-revascularization-and-optimal-medical-therapy-for-chronic-total-coronary-occlusions EXPLORE https://www.jacc.org/doi/abs/10.1016/j.jacc.2016.07.744 ISCHEMIA CTO https://www.clinicaltrials.gov/study/NCT03563417   IV ACC and EHRA Preview Mandrola's 5 Trials to Look for at the 2025 American College of Cardiology Scientific Sessions https://www.medscape.com/viewarticle/mandrolas-5-trials-look-2025-american-college-cardiology-2025a10006zu You may also like: The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net

Silent cerebral embolism after LAAC, AI in ECG rhythm analysis, anti-thrombotic strategies in patients with AF and CAD, and subclinical AF are the topics John Mandrola, MD, covers in today's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I. Silent Cerebral Embolism after LAAC JAHA Case Series  https://www.ahajournals.org/doi/10.1161/JAHA.124.037968 JACC  https://doi.org/10.1016/j.jacc.2018.12.039 II. AI Transforming Rhythm Monitor Reading Johnson and colleagues RCT https://www.nature.com/articles/s41591-025-03516-x III. Anticoagulation Alone or OAC plus antiplatelets in patients with CAD and AF Rashedi and colleagues Meta-analysis https://doi.org/10.1016/j.jacc.2024.12.030 AQUATIC https://clinicaltrials.gov/study/NCT04217447 IV. DOAC for Subclinical AF – A Subgroup Analysis of ARTESIA Anticoagulation Uncertainty in Embolic Stroke of Undetermined Source https://www.medscape.com/viewarticle/anticoagulation-uncertainty-embolic-stroke-undetermined-2024a1000h5e Lancet Neurology Subgroup Analysis of ARTESIA 10.1016/S1474-4422(24)00475-7 ARTESIA https://www.nejm.org/doi/full/10.1056/NEJMoa2310234 NOAH https://www.nejm.org/doi/full/10.1056/NEJMoa2303062 RE-SPECT ESUS https://www.nejm.org/doi/full/10.1056/NEJMoa1813959 NAVIGATE ESUS https://www.nejm.org/doi/full/10.1056/NEJMoa1802686 You may also like: The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net

In this week's replay episode from 2023, we speak with Associate Professor of Pediatrics at Mount Sinai, Dr. Jennifer Cohen about a recent large scale Fetal Heart Society project she conducted on the topic of fetal ccTGA and outcomes. What observations in fetal life are associated with worse clinical outcomes? Why is it valuable to perform serial fetal echocardiograms in this patient group? How common are genetic or extracardiac abnormalities in this patient group? These are amongst the many questions reviewed with Dr. Cohen this week. DOI: 10.1161/JAHA.122.029706

US doc's pay, the ticagrelor controversy and new RCTs, clopidogrel beats ASA, holding antiplatelets for non-cardiac surgery, and Prof Cleland and ASA dogma are the topics John Mandrola, MD, covers this week. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I. US Healthcare Mandrola's Top 10 Stories in 2024 https://www.medscape.com/viewarticle/mandrolas-top-10-stories-2024-2024a1000mxe?_gl=1*dcvmkh*_gcl_au*MTgzOTY2ODQ0Ni4xNzI5MjU4NjUz CMS Proposal II. Ticagrelor Controversy New Investigation Casts Doubt on Landmark Ticagrelor Trial https://www.medscape.com/viewarticle/new-investigation-casts-doubt-landmark-ticagrelor-trial-2024a1000n1d Doshi Review https://www.bmj.com/content/387/bmj.q2550 PLATO https://www.nejm.org/doi/full/10.1056/NEJMoa0904327 ISAR REACT 5 https://www.nejm.org/doi/full/10.1056/NEJMoa1908973 Bates Review https://www.ahajournals.org/doi/epub/10.1161/JAHA.123.031606 Victor Serebuany and Dan Atar Editorial https://doi.org/10.1093/eurheartj/ehp545 III. New Ticagrelor vs Clopdiogrel trial Preprint: https://www.medrxiv.org/content/10.1101/2024.11.06.24316875v1.full-text IV. Clopidogrel Better Than ASA Even in HBR Substudy Long-Term Aspirin vs Clopidogrel After Coronary Stenting by Bleeding Risk and Procedural Complexity HOST-EXAM 10.1016/S0140-6736(21)01063-1 HOST-EXAM-Extended https://doi.org/10.1161/CIRCULATIONAHA.122.062770 V. ASA During Non-Cardiac Surgery ASSURE DES https://doi.org/10.1016/j.jacc.2024.08.024 VII. Professor Cleland on ASA for Secondary Prevention Cleland Editorial https//jamanetwork.com/journals/jamacardiology/article-abstract/2827201 ASA Meta-analysis 10.1016/S0140-6736(09)60503-1 AMIS https://jamanetwork.com/journals/jama/fullarticle/368745 SAPAT 10.1016/0140-6736(92)92619-Q You may also like: The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net