Podcasts about Perfusion

”J'avais une révolte, une colère et de l'espoir à exprimer”François Ruffin est député de la Somme et candidat à la candidature pour les présidentielles de 2027.Avant les débats de l'hémicycle et les ambitions de pouvoir, il a passé 26 ans sur le terrain, à sillonner la France pour retranscrire le réel.Précurseur d'un journalisme plus authentique, il se met lui-même en scène dans différents formats pour son propre journal Fakir, à la radio, dans ses livres et reportages.En 2016, François publie “Merci Patron !”, un documentaire satirique dans lequel il défend une famille en détresse contre leur ancien employeur Bernard Arnault.Le succès de ce documentaire érige François en nouvelle figure de la gauche et lance véritablement sa carrière politique.En 2017 il crée son mouvement “Picardie Debout !”, fait campagne et devient député lors des législatives de juin.Je voulais recevoir François sur GDIY depuis de nombreuses années pour creuser cette facette “Do It Yourself” qu'il a et qui est de plus en plus rare chez les hommes/femmes politiques. Avoir une des têtes de la gauche était l'occasion d'aborder les sujets qui fâchent souvent, mais nous concernent tous :Pourquoi nos gouvernements ont tant de mal à réguler les dépenses publiques ?Quels doivent être les grands combats de la France pour les 5 prochaines années ?Peut-on être de gauche et être pro-business ?Ce que l'on risque si on ne reprend pas rapidement en main notre industrie ?François dresse le tableau d'un État perfusion qu'il est temps de repenser en profondeur.Une discussion à bâtons rompus avec un homme de convictions qui nous plonge en avance dans les grands sujets qui animeront le débat public jusqu'aux présidentielles.Vous pouvez suivre François sur Instagram et sur X.TIMELINE:00:03:00 : Pourquoi la gauche est si fâchée avec le business00:14:24 : Comment protéger les métiers qui portent la société00:22:48 : Arrêter d'opposer l'individu et le collectif00:28:53 : Mettre fin aux subventions aveugles00:38:55 : Le problème d'une société menée plus par le capital que par le travail00:45:10 : Exprimer sa révolte par le journalisme00:57:30 : Le gâchis productif qui tue la France de l'intérieur01:09:06 : Pourquoi l'IA n'est pas une priorité pour les politiques01:21:52 : L'urgence de reprendre en main notre industrie de défense01:32:25 : « J'aurais au moins vécu ça »Les anciens épisodes de GDIY mentionnés : #401 - Emmanuel Macron - Président de la République - Les décisions les plus lourdes se prennent seul#503 - Maxime Aiach - Acadomia, Shiva - Créer 2 millions d'emplois sans embaucher#420 - Stanislas Niox-Chateau - Doctolib : derrière la plus grosse marque de la French tech#500 - Reid Hoffman - LinkedIn, Paypal - Comment dompter l'invention la plus puissante de l'humanité#388 - Benoit Lemaignan - Verkor - “Pour avoir de l'impact climatique il faut aller vite et fort”Nous avons parlé de :Journal FakirLe documentaire “Merci Patron !”Le documentaire “J'veux du soleil”Le documentaire “Debout les femmes !”Le documentaire “Au boulot !”La bibliographie de FrançoisLa proposition de loi de François Ruffin sur les femmes de ménage “Encadrer la sous-traitance, cesser la maltraitance”Le CICE, Crédit d'Impôt pour la Compétitivité et l'EmploiLa levée de fonds éclair de DuralexJean TeuléDifférence entre le taux de chômage et le taux d'emploiCoffret DVD de tous les documentaires de François, produits avec Gilles PerretLa nouvelle gigafactory de Verkor à DunkerqueLa notion d'armée “bonzaï”Les recommandations de lecture :Mal-travail : Le choix des élites - François RuffinLeur progrès et le nôtre : De Prométhée à la 5G - François RuffinLa grande transformation - Karl PolanyiL'essentiel est invisible pour les yeux. Le Petit Prince - Antoine de Saint-ExupéryLes ritals - François CavannaDes souris et des hommes - John SteinbeckUn grand MERCI à nos sponsors : SquareSpace : squarespace.com/doitQonto: https://qonto.com/r/2i7tk9 Brevo: brevo.com/doit eToro: https://bit.ly/3GTSh0k Payfit: payfit.com Club Med : clubmed.frCuure : https://cuure.com/product-onelyVous souhaitez sponsoriser Génération Do It Yourself ou nous proposer un partenariat ?Contactez mon label Orso Media via ce formulaire.Hébergé par Audiomeans. Visitez audiomeans.fr/politique-de-confidentialite pour plus d'informations.

Invité :François Walraet, secrétaire général de la Coordination ruraleChroniqueurs :Alexandre Devecchio, rédacteur en chef du service débats du FigaroGeorges Fenech, ancien magistrat Hébergé par Audiomeans. Visitez audiomeans.fr/politique-de-confidentialite pour plus d'informations.

Perfusion as a specialty has always evolved in response to advances in cardiac surgery, extracorporeal support, and critical care. This session will explore how future perfusionists may need to redefine their role in healthcare teams. The discussion will focus on technology integration, including artificial intelligence, machine learning, and predictive analytics. Participants will consider how these tools may assist perfusionists in real-time decision-making, patient monitoring, and workflow efficiency. Additionally, the session will examine the professional challenges of the next decade: maintaining relevance within a multidisciplinary team, advancing educational pathways, and navigating ethical questions surrounding emerging technologies such as normothermic regional perfusion (NRP), mechanical circulatory support, and extracorporeal cardiopulmonary resuscitation (ECPR). Future perfusionists must be both technical experts and critical thinkers. They will need to master new tools while maintaining strong clinical judgment in life-saving scenarios. The speaker will also highlight career growth opportunities, including leadership roles in perfusion education, research, and hospital administration.

In this episode of BioTalk, CEO Gerard Eldering explains how Perfusion Medical is addressing a problem that trauma physicians and military medics have been struggling with for decades: capillary compression.  Perfusion Medical is developing a drug aimed at treating hemorrhagic shock and other ischemic conditions. PM‑208 is a novel IV therapeutic designed to restore capillary blood flow, resolve ischemia, and protect vital organs. The team has advanced this work with $19 million in Department of Defense funding. He describes the scale of the unmet need, why PM‑208 is both organ- and disease‑agnostic, and how its simple formulation and strong safety profile position it for broad medical use. Eldering also reflects on the company's path through the BioHealth Capital Region Crab Trap Competition. After a second‑place finish a few years earlier, Perfusion Medical returned to the stage and won the 2025 competition. He shares what that experience has meant for the team and why building the company in the BioHealth Capital Region—particularly from a Virginia base—has been a strategic advantage. The conversation moves through the role of early federal funding and programs like SBIR/STTR in de‑risking breakthrough therapies, and how university research partnerships have strengthened PM‑208's development. Eldering highlights how public‑private collaboration has shaped the company's progress and made it possible to push a complex medical solution toward patients more quickly.   Editing and post-production work for this episode was provided by The Podcast Consultant - https://thepodcastconsultant.com/0   About Gerard Eldering Gerard Eldering is the CEO of Perfusion Medical and a nationally recognized expert in technology transfer and venture formation. Since becoming an entrepreneur in 2007, he has helped launch more than a dozen startups, raised more than $15 million in seed funding, and led the turnaround and sale of a technology consulting firm. Before founding Perfusion Medical, he built and led The MITRE Corporation's Technology Transfer Office. Eldering is a U.S. Air Force veteran who served as a helicopter pilot and instructor. He holds a B.A. in Physics, an M.B.A., and is a registered patent agent.

Interview with Noemi Lois, MD, PhD, author of Retinal Sensitivity and Retinal Perfusion in Diabetic Retinopathy. Hosted by Neil Bressler, MD. Related Content: Retinal Sensitivity and Retinal Perfusion in Diabetic Retinopathy

Interview with Noemi Lois, MD, PhD, author of Retinal Sensitivity and Retinal Perfusion in Diabetic Retinopathy. Hosted by Neil Bressler, MD. An earlier posted version of this podcast may not have stated clearly enough that in areas with loss of perfusion and loss of sensitivity at baseline which remained non-perfused during the follow up, the sensitivity deficit declined over time. This has been corrected in the podcast. Related Content: Retinal Sensitivity and Retinal Perfusion in Diabetic Retinopathy

Liver transplantation continues to evolve as strategies expand to address organ shortage and optimize outcomes. Normothermic machine perfusion (NMP) offers a novel way to preserve and assess donor livers prior to implantation. In this episode of Behind the Knife, our transplant team at University of Nebraska Medical Center discusses the latest evidence from randomized trials, practical applications in donation after circulatory death (DCD) grafts, and how NMP is shaping clinical decision-making in high-risk transplants.  Hosts -  Madeline Cloonan, MD PhD, General Surgery Resident, University of Nebraska Medical Center, @maddie_cloonan   - Jacqueline Dauch, MD, Assistant Professor, University of Nebraska Medical Center  -  Shaheed Merani, MD PhD, Associate Professor, University of Nebraska Medical Center  - Alan Langnas, DO, Professor, University of Nebraska Medical Center  Learning Objectives - Describe the principles of normothermic machine perfusion (NMP) and how it differs from static cold storage.  - Summarize the design and key outcomes of the PROTECT trial and the Chapman et al. trial on NMP in liver transplantation.  - Recognize the clinical scenarios where NMP provides the greatest benefit, particularly in high-risk grafts (e.g., DCD donors, high donor risk index).  - Apply a practical viability assessment framework for livers on NMP, including hemodynamics, bile production, lactate trajectory, and histology when indicated.  - Discuss the implications of NMP for allocation, system logistics, and future adoption trends in transplantation.  References   1.     Markmann JF, Abouljoud MS, Ghobrial RM, et al. Impact of portable normothermic blood-based machine perfusion on outcomes of liver transplant: the OCS Liver PROTECT randomized clinical trial. JAMA Surg. 2022;157(3):189-198. doi:10.1001/jamasurg.2021.6781. https://pubmed.ncbi.nlm.nih.gov/34985503/ 2.     Chapman WC, Barbas AS, D'Alessandro AM, et al. Normothermic machine perfusion of donor livers for transplantation in the United States: a randomized controlled trial. Ann Surg. 2023;278(5):e912-e921. doi:10.1097/SLA.0000000000005934. https://pubmed.ncbi.nlm.nih.gov/37389552/ 3.     Nasralla D, Coussios CC, Mergental H, et al; Consortium for Organ Preservation in Europe. A randomized trial of normothermic preservation in liver transplantation. Nature. 2018;557(7703):50-56. doi:10.1038/s41586-018-0047-9. https://pubmed.ncbi.nlm.nih.gov/29670285/ 4.     Brubaker AL, Sellers MT, Abt PL, et al. US liver transplant outcomes after normothermic regional perfusion vs standard super rapid recovery. JAMA Surg. 2024;159(6):677-685. doi:10.1001/jamasurg.2024.0520. https://pubmed.ncbi.nlm.nih.gov/38568597/ 5.     Wall A, Snoddy M, Du J, et al. The current landscape of in situ and ex situ machine perfusion utilization for liver grafts from cardiac donation after circulatory death donors in the US. Am J Transplant. 2025;25(3):574-582. doi:10.1016/j.ajt.2024.09.012. https://pubmed.ncbi.nlm.nih.gov/39293517/ 6.     Watson CJE, Gaurav R, Fear C, Swift L, Selves L, Ceresa CDL, Upponi SS, Brais R, Allison M, Macdonald-Wallis C, Taylor R, Butler AJ. Predicting Early Allograft Function After Normothermic Machine Perfusion. Transplantation. 2022 Dec 1;106(12):2391-2398. doi: 10.1097/TP.0000000000004263. https://pubmed.ncbi.nlm.nih.gov/36044364/ 7.     Watson CJE, Hunt F, Messer S, Currie I, Large S, Sutherland A, Crick K, Wigmore SJ, Fear C, Cornateanu S, Randle LV, Terrace JD, Upponi S, Taylor R, Allen E, Butler AJ, Oniscu GC. In situ normothermic perfusion of livers in controlled circulatory death donation may prevent ischemic cholangiopathy and improve graft survival. Am J Transplant. 2019 Jun;19(6):1745-1758. doi: 10.1111/ajt.15241. https://pubmed.ncbi.nlm.nih.gov/30589499/ 8.     Olthoff KM, Kulik L, Samstein B, et al. Validation of a current definition of early allograft dysfunction in liver transplant recipients and analysis of risk factors. Liver Transpl. 2010;16(8):943-949. doi:10.1002/lt.22091.https://pubmed.ncbi.nlm.nih.gov/20677285/  9.     Kwong AJ, Kim WR, Lake JR, Schladt DP, Handarova D, Howell J, Schumacher B, Weiss S, Snyder JJ, Israni AK. OPTN/SRTR 2023 Annual Data Report: Liver. Am J Transplant. 2025 Feb;25(2S1):S193-S287. doi: 10.1016/j.ajt.2025.01.022. https://pubmed.ncbi.nlm.nih.gov/39947804/ Ad Disclosures: Visit goremedical.com/btk to learn more about GORE® ENFORM Biomaterial. Refer to Instructions for Use at eifu.goremedical.com for a complete description of all applicable indications, warnings, precautions and contraindications for the markets where this product is available. Rx only Please visit https://behindtheknife.org to access other high-yield surgical education podcasts, videos and more.   If you liked this episode, check out our recent episodes here: https://behindtheknife.org/listen Behind the Knife Premium: General Surgery Oral Board Review Course: https://behindtheknife.org/premium/general-surgery-oral-board-review Trauma Surgery Video Atlas: https://behindtheknife.org/premium/trauma-surgery-video-atlas Dominate Surgery: A High-Yield Guide to Your Surgery Clerkship: https://behindtheknife.org/premium/dominate-surgery-a-high-yield-guide-to-your-surgery-clerkship Dominate Surgery for APPs: A High-Yield Guide to Your Surgery Rotation: https://behindtheknife.org/premium/dominate-surgery-for-apps-a-high-yield-guide-to-your-surgery-rotation Vascular Surgery Oral Board Review Course: https://behindtheknife.org/premium/vascular-surgery-oral-board-audio-review Colorectal Surgery Oral Board Review Course: https://behindtheknife.org/premium/colorectal-surgery-oral-board-audio-review Surgical Oncology Oral Board Review Course: https://behindtheknife.org/premium/surgical-oncology-oral-board-audio-review Cardiothoracic Oral Board Review Course: https://behindtheknife.org/premium/cardiothoracic-surgery-oral-board-audio-review Download our App: Apple App Store: https://apps.apple.com/us/app/behind-the-knife/id1672420049 Android/Google Play: https://play.google.com/store/apps/details?id=com.btk.app&hl=en_US

PerfWeb 105 Day 2 focuses on the impact of hemoglobin on oxygen delivery (DO₂), a fundamental concept in perfusion practice. This session examines the relationship between hemoglobin concentration and systemic oxygen transport, with direct implications for patient safety and clinical decision-making during cardiopulmonary bypass. Designed for practicing perfusionists, board exam candidates, and healthcare professionals, the program blends theory with real-world applications in perfusion. Learning Highlights: The role of hemoglobin in oxygen delivery (DO₂). Physiological principles behind oxygen transport, Strategies to optimize DO₂ during bypass, Clinical relevance of hemoglobin levels in perfusion outcomes.

This PerfWeb session focuses on perfusionist board exam preparation with a live Q&A panel of certified perfusionists. The faculty will answer challenging questions directly related to board certification, offering valuable insights for candidates preparing to enter the field. Additionally, the webinar examines the clinical application of ultrafiltration during cardiopulmonary bypass, highlighting its role in managing fluid status, balancing electrolytes, and reducing inflammatory mediators. Learning Highlights: Panel Q&A: Certified perfusionists answer board exam questions. Ultrafiltration in perfusion practice: clinical applications, Managing fluid balance and reducing inflammatory mediators

Aujourd'hui, Joëlle Dago-Serry, coach de vie, Mourad Boudjellal, éditeur de BD, et Jérôme Marty, médecin généraliste, débattent de l'actualité autour d'Alain Marschall et Olivier Truchot.

Staffing Crisis, and Accountability in Perfusion Practice.

Pour ce premier épisode de la saison 3 de Beau Voyage, nous avons le bonheur de recevoir Evane Haziza-Bonnamour, l'une des créatrices du génial magazine Voyage Voyage qui révolutionne l'art de voyager et que nous adorons chez BeauVoyage. Issue d'une famille d'agents de voyage depuis trois générations, Evane nous raconte comment elle et son associé Fabien ont osé créer leur propre magazine indépendant avec une philosophie bien particulière qui consiste à sortir des sentiers battus et redorer les lettres de noblesse du voyage.Dans cette conversation passionnante, Evane nous dévoile les coulisses de la création audacieuse d'un magazine indépendant dans un secteur en crise et leur concept unique qui mélange destinations pointues et authenticité locale. Elle revient sur le timing à la fois parfait et risqué de leur lancement juste avant le Covid, et nous explique comment ils osent publier des couvertures sombres sur la route de la soie quand tout le monde mise sur les plages grecques.Evane nous fait également découvrir les secrets de fabrication d'un numéro depuis l'inspiration jusqu'à la réalisation, l'art de voyager avec un enfant de trois ans avec pour destination favorite le Japon, ses galères de voyage les plus mémorables comme ce fameux mal des montagnes au Pérou qui l'a menée sous perfusion, ainsi que ses coups de cœur absolus tel que le Sri Lanka hors saison. Evane nous livre aussi ses astuces pour concilier vie de famille et voyages de quinze jours aux quatre coins du monde.Nous avons adoré enregistrer cet épisode avec Evane et espérons qu'il vous plaira tout autant.Merci d'être toujours plus nombreux à nous suivre et à nous écouter, belle écoute ! Hébergé par Acast. Visitez acast.com/privacy pour plus d'informations.

Z-BUF, Staffing Crisis, and Accountability in Perfusion Practice.

Putting To Rest The Idea That Ultrafiltration On CPB Causes Renal Failure.

 I went to work one day and died. A perfusionist's journey.

What if one of biotech's biggest production breakthroughs was hiding in plain sight? Not in a new gene or a wonder drug, but in the way we process and purify biologics.Perfusion technology, once dismissed as a pipedream in top biopharma boardrooms, is now quietly powering some of the industry's most efficient and productive manufacturing platforms. Yet, transforming perfusion from controversial buzzword to gold standard required timing, vision, and a willingness to break from tradition.In this episode, host David Brühlmann sits down with Jarno Robin, a bioprocessing pioneer whose 20+ year journey spans industry giants like Novo Nordisk, Sanofi, and Leo Pharma. Jarno has championed upstream continuous processes, including ATF and TFF, for decades, and now, as a leader at Sani Membranes, he's unleashing the next evolution: Vibro® Membrane Filtration, an innovation set to upend conventional wisdom about fouling, pressure loss, scalability, energy usage, and more.Here are three reasons you'll want to listen to Jarno's journey:Innovation Versus Industry Inertia: Behind every platform shift are years of resistance. Jarno recounts how timing, advocacy, and matching the right data with the right decision-makers finally made perfusion mainstream, even after company leaders proclaimed, “We will never ever run perfusion.”State-of-the-Art and the Next Frontier: ATF and TFF remain dominant, but their limitations, like membrane fouling, scale-up headaches, and high energy needs, are real. Jarno explains how Vibro® Membrane Filtration addresses these pain points with a radically new design, offering lower pressure loss, less fouling, higher cell densities, and surprisingly low energy consumption.Practical Wisdom for Bioprocess Developers: Should you always run a control in process development? How do you translate lab-scale wins to robust, money-earning production? Jarno shares counterintuitive advice based on decades of hands-on success and mistakes.Curious how you can optimize your process technology and sidestep costly pitfalls? Listen to this episode and discover how “timing is everything” in bioprocessing innovation and whether new filtration methods could help you leap ahead.Connect with Jarno Robin:LinkedIn: www.linkedin.com/in/jarno-robinWebsite: www.sanimembranes.comCurious about continuous processing challenges and breakthroughs? Don't miss these previous episodes.Episodes 39-40: Balancing Perfusion Process Development and Sustainability with Jochen SieckEpisodes 85-86: Bioprocess 4.0: Integrated Continuous Biomanufacturing with Massimo MorbidelliEpisodes 153-154: The Future of Bioprocessing: Industry 4.0, Digital Twins, and Continuous Manufacturing Strategies with Tiago MatosNext step:Book a free consultation to help you get started on any questions you may have about bioprocess development: https://bruehlmann-consulting.com/call

Weaning the fiO2 on VA ECMO. Is This Safe Practice?

When to Say Enough. The Difficulty of Recognizing Futility in the Patient on ECMO.

Join Jay Gunkelman, QEEGD (the man who has analyzed over 500,000 brain scans), and host Pete Jansons for another engaging NeuroNoodle Neurofeedback Podcast episode discussing neuroscience, psychology, mental health, and brain training.✅ Topic 1 Explained: Learn how brain temperature affects neurological functioning, cognition, and the risk of dysfunction at high core temperatures.✅ Topic 2 Deep Dive: We explore the controversial concept of “God frequencies” and the Schumann Resonances—natural earth-based electromagnetic frequencies often misused in marketing.✅ Topic 3 Insights: Jay shares fascinating EEG data from healing studies, showing entrainment between healer and subject using cross-frequency coupling and standing wave potentials.✅ Additional Topics:

Massive Hemorrhage of an ECMO Patients - Requiring Six Full MTP's

On this episode of JHLT: The Podcast, the Digital Media Editors invite first author Gaurav Sharma, PhD, MBA, from the University of Texas Southwestern Medical Center in Dallas. Dr. Sharma discusses his paper, “Metabolic and transcriptomic insights into temperature controlled hypothermic preservation of human donor hearts.” The discussion explores: How donor hearts not offered or declined for transplantation responded in hypothermic preservation versus conventional static cold storage Potentially beneficial genetic signatures yielded by TCHP versus cold storage The surprising response of energy stores in the hearts to the different storage environments How multi-omic approaches could be applied to other organs For the latest studies from JHLT, visit www.jhltonline.org/current, or, if you're an ISHLT member, access your Journal membership at www.ishlt.org/jhlt. Don't already get the Journal and want to read along? Join the International Society of Heart and Lung Transplantation at www.ishlt.org for a free subscription, or subscribe today at www.jhltonline.org.

With Edward Hulten, Brown University, Providence, and Islam Shatla, University of Kansas Medical Center, Kansas City, USA. Link to edi

Join us for a continuation of our conversation with perfusionist Jordan Brimhall and Brandon Lowe, RRT, NPS, lead ECMO specialist at Emory in Atlanta. We discuss multidisciplinary collaboration in pediatric ECMO programs. Hosts: Deanna Todd Tzanetos, MD, MSCI (Norton Children's/UofL) and Chris Knoll, MD (Phoenix Children's). Guests Jordan Brimhall MS, CPP, FPP (Phoenix Children's) Brandon Lowe, RRT, NPS (Emory) Editing/Production (Deanna Todd Tzanetos, MD, MSCI)

This session dives into innovative machine perfusion techniques, advanced perfusates, and logistics breakthroughs aimed at extending organ viability and improving transplant outcomes. Packed with real-world case studies, expert insights, and interactive Q&A, this focused 1.2‑CEU webinar spotlights how modern technology is revolutionizing the way donor organs are preserved, transported, and ultimately saved.

Dive into the ethical dilemmas and controversies surrounding perfusion practices. This session, presented by Perfusion Education and streamed within the last month, tackles tough questions such as informed consent, allocation equity, risk-benefit analysis of experimental techniques, and real-world case studies. Essential for perfusionists, transplant professionals, and bioethicists, this discussion offers practical insights and stimulating debate to inform ethical decision-making in modern perfusion.

A comprehensive literature review on Normothermic Regional Perfusion (NRP) led by Samir Patel, MD, CCP, LP. Streamed on June 2, 2025, this session explores the latest research and emerging technologies in NRP, spotlighting its clinical applications, ethical considerations, and protocol development in perfusion practice. Ideal for perfusionists and transplant specialists, this episode packs 1.2 CEUs of expert insight into a field reshaping organ donation strategies.

Everything you wanted to know about perfusion but were afraid to ask. Join us for a conversation with Jordan Brimhall, MS, CCP, FPP Chief Perfusionist at Phoenix Children's Hospital. We discuss what really happens in the OR and what intensivists should know and understand about cardiopulmonary bypass. Hosts: Deanna Todd Tzanetos, MD, MSCI Norton Children's/ U of Louisville and Chris Knoll, MD Phoenix Children's Editor/Producer: Deanna Todd Tzanetos

Poiseuille's Law drives perfusion, and J. Basha, CCP, dissects why it's our physics Bible. He'll unpack flow's reliance on pressure, radius, length, and viscosity—key to circuits and patients. I'll recall early days when a tiny radius tweak tanked a case. You'll apply it to cannulas, tubing, and viscosity control via temp and Hgb. Calculate flows, predict pressures, fix problems fast. Perfusionists live this; OR teams peek into our world. After 40 years, I lean on Poiseuille daily—build your foundation here. Myocardial Protection Strategies: Why Do We Still See RV Dysfunction and Failure? Protecting the heart is cardiac surgery's core, yet RV dysfunction haunts us. J. Basha, CCP, digs into why and how to fight it. Basha will revisit cardioplegia basics—delivery, mixes, temps—then zero in on the RV's quirks and vulnerability. I'll share RV failures that taught me to watch it closer than the LV. Expect advanced moves: retrograde cardioplegia, RV tweaks, and handling pulmonary hypertension. Learn to spot and stop RV trouble from pre-op to post-op. Perfusionists need this; surgeons and anesthesiologists will align better with it. Crack the RV puzzle with us. Stand Your Ground: The AmSECT Guidelines on Hgb. Right or Wrong? Presenter: J. Basha, CCP, Audience Call-In. AmSECT's Hgb guidelines divide us—love 'em or hate 'em, they're up for debate. J. Basha, CCP, leads this call-in clash. Basha lays out the rules, the evidence, and the gripes. Then it's on: Do you stick to them or trust your gut? We'll argue universal thresholds, transfusion risks, and adjuncts like EPO. Bring your stance—students, pros, all voices count. Refine your practice in this showdown. Join us to stand your ground or find new footing.

Protecting the heart is cardiac surgery's core, yet RV dysfunction haunts us. J. Basha, CCP, digs into why and how to fight it. Basha will revisit cardioplegia basics—delivery, mixes, temps—then zero in on the RV's quirks and vulnerability. I'll share RV failures that taught me to watch it closer than the LV. Expect advanced moves: retrograde cardioplegia, RV tweaks, and handling pulmonary hypertension. Learn to spot and stop RV trouble from pre-op to post-op. Perfusionists need this; surgeons and anesthesiologists will align better with it. Crack the RV puzzle with us. What Is Reperfusion Injury and How Can It Be Avoided? Presenter: S. Patel, MD Reperfusion injury is the cruel twist of restoring flow only to harm more. Dr. S. Patel unravels this and offers fixes. He'll trace its roots—ischemia's setup, reperfusion's chaos of inflammation and cell death—and its RV toll. I'll tell of a case where cardioplegia wasn't enough, but smart moves won out. We'll cover controlled reperfusion, leukocyte filters, and medications such as adenosine, as well as new concepts like preconditioning. Perfusionists, surgeons, researchers—this is your playbook to dodge the paradox—master safe reperfusion with Patel and my 40-year lens.

Send us a textThe simple ice pack - a staple in both human and veterinary medicine for reducing pain and swelling. But what if this common therapy has unexpected consequences for healing? Soft tissue surgeon Dr. Vanna Dickerson and veterinary student Gabriella Hansen join us to discuss their fascinating research on how ice packs affect blood flow in canine skin.For years, surgeons have cautioned against using ice after delicate skin procedures like flaps and grafts, believing it might compromise blood flow. However, this advice lacked scientific backing until now. Through precise measurements using laser speckle contrast imaging, Dr. Dickerson and Hansen discovered that ice application reduces skin perfusion by 10-15% compared to baseline - and surprisingly, in some dogs, blood flow remained decreased even 15 minutes after the ice was removed.This groundbreaking work confirms what many surgeons suspected but couldn't prove, giving veterinarians evidence-based guidance for post-operative care decisions. Dr. Dickerson and Hansen emphasize that ice remains valuable for pain control in most situations, but surgeons should exercise caution in cases where even small perfusion decreases could jeopardize healing. For pet owners, understanding these nuances helps explain why your veterinarian might specifically recommend for or against icing in different scenarios.Beyond the clinical findings, Dr. Dickerson and Hansen offer valuable insights for veterinary students interested in research, encouraging them to find mentors and emphasizing that meaningful studies don't require complex laboratory setups. Their work exemplifies how asking simple questions about everyday practices can lead to significant improvements in patient care. Listen now to discover how this common therapy affects your pet's healing and what questions still remain for future investigation.AJVR article: https://doi.org/10.2460/ajvr.25.01.0023INTERESTED IN SUBMITTING YOUR MANUSCRIPT TO JAVMA ® OR AJVR ® ? JAVMA ® : https://avma.org/JAVMAAuthors AJVR ® : https://avma.org/AJVRAuthorsFOLLOW US:JAVMA ® : Facebook: Journal of the American Veterinary Medical Association - JAVMA | Facebook Instagram: JAVMA (@avma_javma) • Instagram photos and videos Twitter: JAVMA (@AVMAJAVMA) / Twitter AJVR ® : Facebook: American Journal of Veterinary Research - AJVR | Facebook Instagram: AJVR (@ajvroa) • Instagram photos and videos Twitter: AJVR (@AJVROA) / Twitter JAVMA ® and AJVR ® LinkedIn: https://linkedin.com/company/avma-journals

In this concluding episode of our deep dive into miniaturized perfusion systems, we tackle the most challenging aspect: implementing meaningful process analytical technology (PAT) at microscale while keeping costs realistic for high-throughput applications.Tom Valentin, group leader at CSEM for Automated Sample Handling, continues sharing CSEM's pioneering work in automated sample handling, revealing both the breakthrough opportunities and stubborn technical barriers that define the current state of small-scale perfusion development.Critical insights you'll gain from this episode:The PAT miniaturization challenge is about more than size: While optical density sensors work reasonably well for microbial cultures, mammalian cell applications demand more sophisticated solutions. Tom explains why viable cell density remains the "holy grail"—and how promising technologies from companies like IMEC and Inspec are pushing the boundaries, though cost-effective 96-well implementation remains elusiveSmart compromises can unlock practical solutions: Tom reveals why the industry may need to accept hybrid approaches—real-time pH and DO monitoring combined with once-daily viable cell density sampling. He also explains the unique challenges of sensor positioning in shaking deep-well plates where liquid dynamics create measurement complexitiesPartnership models that actually work for biotech innovation: Beyond the technical discussion, Tom outlines CSEM's proven collaboration approaches, including how Innoswiss funding can provide 50% cost reduction for development projects and why their 70% proposal success rate makes them an attractive R&D partner for both startups and established pharma companiesDiscover how bioprocessing is evolving - from high-throughput screening to digital twins and continuous manufacturing- in these expert-led episodes.Episode 155: From Process Bottlenecks to Seamless Production: How Continuous Bioprocessing Changes EverythingEpisodes 153-154: The Future of Bioprocessing: Industry 4.0, Digital Twins, and Continuous Manufacturing Strategies with Tiago MatosEpisodes 85-86: Bioprocess 4.0: Integrated Continuous Biomanufacturing with Massimo MorbidelliEpisodes 73-74: Bead-Based Assays: The Power of High-Throughput Screening with Sebastian GiehringConnect with Tom Valentin:LinkedIn: www.linkedin.com/in/tom-valentin-5bb9091bWebsite: www.csem.ch/enEmail: thomas.valentin@csem.chNext step:Book a free consultation to help you get started on any questions you may have about bioprocessing analytics: https://bruehlmann-consulting.com/callDevelop bioprocessing technologies better, faster, at a fraction of the cost with our 1:1 Strategy Call: The quickest and easiest way to excel biotech technology development. Book your call at www.bruehlmann-consulting.com/call/Support the show

In bioprocess development, the ability to rapidly screen conditions and predict scale-up performance can mean the difference between a successful therapy launch and costly delays. Today's Smart Biotech Scientist episode features Tom Valentin from CSEM, who's pioneering revolutionary approaches to miniaturized perfusion systems that could transform how we develop biologics.Tom is a group leader at CSEM for Automated Sample Handling within the Life Sciences and Industry 4.0 business unit. As a mechanical and biomedical engineer, he brings a unique cross-disciplinary perspective to solving bioprocessing's most challenging miniaturization problems.What makes this conversation essential listening:96-deep-well plates are revolutionizing perfusion development: Tom reveals how CSEM's innovative fluidic lids enable continuous medium exchange in 300-microliter volumes, potentially allowing up to 96 parallel perfusion experiments with automated liquid handlers and shaker incubatorsThree critical barriers still need solving: Despite the promise, Tom identifies the key technical challenges that must be overcome: ultra-low flow rate liquid handling (imagine exchanging 300 μL over 24 hours), effective cell retention in miniaturized systems, and cost-effective real-time biomonitoring that fits within well plate constraintsThe future of process development is automated and intelligent: From pressure-over-liquid systems to advanced sensor integration, Tom outlines how companies can achieve near-autonomous perfusion screening—but warns that current sensing limitations mean viable cell density monitoring remains the "holy grail" of small-scale perfusionThis isn't just about smaller equipment—it's about fundamentally changing how we approach process development. If you're working in cell culture optimization, process scale-up, or bioprocess automation, Tom's insights reveal both the tremendous opportunities and practical realities of implementing next-generation perfusion systems.For biotech professionals, staying ahead means embracing these high-throughput, data-rich models, allowing smarter, faster, and more predictive process development for the therapies of tomorrow.Discover how bioprocessing is evolving - from high-throughput screening to digital twins and continuous manufacturing- in these expert-led episodes.Episode 155: From Process Bottlenecks to Seamless Production: How Continuous Bioprocessing Changes EverythingEpisodes 153-154: The Future of Bioprocessing: Industry 4.0, Digital Twins, and Continuous Manufacturing Strategies with Tiago MatosEpisodes 85-86: Bioprocess 4.0: Integrated Continuous Biomanufacturing with Massimo MorbidelliEpisodes 73-74: Bead-Based Assays: The Power of High-Throughput Screening with Sebastian GiehringConnect with Tom Valentin:LinkedIn: www.linkedin.com/in/tom-valentin-5bb9091bWebsite: www.csem.ch/enEmail: thomas.valentin@csem.chNext step:Book a free consultation to help you get started on any questions you may have about bioprocessing analytics: https://bruehlmann-consulting.com/callDevelop bioprocessing technologies better, faster, at a fraction of the cost with our 1:1 Strategy Call: The quickest and easiest way to excel biotech technology development. Book your call at www.bruehlmann-consulting.com/call/Support the show

Host Sotirios Evangelou, MD, FSCCT is joined by Gianluca Pontone, MD, PhD, FSCCT to explore the evolving role of stress cardiac CT perfusion, from its early limitations to today's advanced scanners capable of capturing dynamic myocardial perfusion in just a few beats. Together, they discuss how this technique helps quantify blood flow and identify hypoperfused regions with precision. 

Stand Your Ground - Raging Fireside Chat Presenter: J. Basha, CCP, Open to Audience After two days of transplant deep dives, J. Basha, CCP, hosts a two-hour open chat to wrestle with the big issues—and you're the spark. This is no passive wrap-up. Bring your takes on NRP ethics, OCS costs, or organ shortages. I'll share 40 years of perfusion fights, like pushing for innovation when tradition stalled. We'll spar over opt-out systems, machine perfusion's price tag, and allocation fairness. It's a chance to challenge, learn, and grow—perfusionists, coordinators, and anyone. Join the fireside fray to ignite real change.

Mastering NRP for Organ Donation Success NRP is rewriting organ donation rules, and Matt Warhoover, CCP, takes you inside this bold frontier over a two-hour session. Using ECMO or bypass, NRP restarts circulation after circulatory death to recover organs in situ. Warhoover will cover cannulation, perfusion, and the ethics of this gray zone. I'll weigh in on its promise—like turning DCD into multi-organ wins—and its hurdles. You'll compare it to standard methods and see its impact on the donor pool. Perfusionists will find new turf here; transplant pros will grasp its potential. Dive in to shape the future of donation.

Dr. Iyad Alnahhas interviews Dr. Peter LaViolette about his and his team's recent manuscript entitled: "Multi-Site Retrospective Analysis of Diffusion and Perfusion MRI Correlates to Glioma Characteristics Derived from Radio-Pathomic Maps", published online in Neuro-Oncology in February 2025.

Organ Availability for Transplant in the U.S. Presenter: S. Patel, MD Time: 10:00–11:00 Transplantation saves lives, but the organ shortage is a brutal bottleneck. Dr. S. Patel digs into this crisis, where over 100,000 wait and too many don't make it. He'll lay out the stats, policies, and ethics—why donor rates lag and who gets priority. I'll add my OR view: the highs of a transplant win, the lows when organs don't come. Dr. Patel will spotlight solutions like opt-out donation and perfusion's role in preservation. For perfusionists, this ties to our work; for healthcare pros, it's the big picture. Join us to see how we can close the gap—one organ, one patient at a time. Organ Procurement Techniques Presenter: S. Patel, MD Time: 11:00–12:00 Organ procurement is a high-wire act—surgery, timing, and teamwork in a race against ischemia. Dr. S. Patel unveils the process from donor consent to preservation. He'll detail organ-specific needs—kidneys versus hearts, livers needing extra care—and preservation tricks like cooling and solutions. I'll share a near-miss when a delayed flight tested our heart transport skills. You'll get the latest on machine perfusion, too. Perfusionists will prize this; surgeons and coordinators will sync better with it. This session arms you to keep organs viable for their next life. OCS (Organ Care System) Presenter: J. Basha, CCP Time: 12:00–13:00 The Organ Care System (OCS) is a transplant revolution, and J. Basha, CCP, shows why it's a game-changer I've seen work wonders. Unlike cold storage, OCS perfuses organs with warm, oxygenated blood, extending viability. Basha will explain its use for hearts, lungs, and livers, and how it rescues borderline organs. I'll recount an OCS save—a distant heart that beat strong thanks to this tech. Learn setup, monitoring, and troubleshooting to cut ischemic damage. Perfusionists will level up; transplant teams will broaden their reach. See why OCS is the future and how to wield it.

Stand Your Ground in the Raging Inferno Presenter: J. Basha, CCP, Open to Audience Participation  After two packed days, we tie it together in a fiery roundtable led by J. Basha, CCP. This isn't a sit-back session—it's a gloves-off discussion of PerfWeb 100's topics, and you're in the ring. Basha will steer us through RAPP, Hgb thresholds, ultrafiltration, and fluid balance, but your questions and challenges fuel the fire. I'll toss in tales from 40 years, like when I stood firm against a crystalloid-happy surgeon. We'll debate: Is there a perfect Hgb cutoff? When is ultrafiltration too much? It's a chance to learn from peers, experts, and your grit. Students and pros alike will sharpen their edge here. Jump into the inferno—let's forge stronger practices together.

Benefits of Ultrafiltration Presenter: J. Basha, CCP Ultrafiltration hit perfusion like a lifeline, giving us control over fluid overload when diuretics alone wouldn't cut it. J. Basha, CCP, leads this session to show why it's a cornerstone of my practice after 40 years. Basha will break down how ultrafiltration strips out excess water and solutes via semi-permeable membranes, while keeping proteins and cells intact. It's not just fluid removal—it's precision, reducing edema and even inflammatory markers. I'll recall a heart failure case where ultrafiltration got us off bypass when the odds were grim. You'll learn the types (conventional, modified, zero-balance), how to weave it into your circuit, and how to dodge pitfalls like hypotension. Perfusionists will find this essential; OR teams will see its teamwork value. Join us to harness ultrafiltration's power for better outcomes. Assessment of Patient Fluid Balance and Status Presenters: S. Patel, MD, J. Basha, CCP Fluid balance is perfusion's quiet MVP—nail it, and the case flows; botch it, and you're in chaos. Dr. S. Patel and J. Basha team up to decode this critical skill over a two-hour deep dive. They'll cover the tools—CVP, PA pressures, TEE, bioimpedance—and how to read them amid bypass's wild fluid shifts. I'll share my go-to signs, like venous oxygen saturation shifts, that scream trouble early. Expect actionable strategies: pre-op prep, intra-op tweaks, and post-op stability, with tips like using albumin for oncotic pressure. This is for perfusionists, anesthesiologists, and surgeons—it's a team effort.

RAPP (Retrograde Autologous Prime) Presenter: Samir Patel, MD, Graduate Perfusionist Time: 14:00–15:00 Back when I started in perfusion, priming the cardiopulmonary bypass circuit meant dumping in crystalloid and hoping the patient wouldn't drown in fluid overload. Then RAPP—Retrograde Autologous Prime—came along and flipped the script. In this session, Dr. Samir Patel, a skilled graduate perfusionist, dives into this game-changing technique that uses the patient's own blood to prime the circuit, slashing hemodilution and preserving hematocrit. Dr. Patel will walk you through the nuts and bolts: draining venous blood, displacing crystalloid, and reinfusing—all while keeping the patient stable. I'll share a standout case where RAPP saved the day for a Jehovah's Witness patient who refused transfusions—proof of its worth. You'll master cannula placement, pressure control, and timing, plus learn how RAPP cuts transfusion rates and post-op complications. Whether you're a newbie or a veteran, this lecture will sharpen your skills and show why RAPP's a must-have in my toolkit Hgb Thresholds Presenter: Samir Patel, MD, Graduate Perfusionist Time: 15:00–16:00 Hemoglobin thresholds have sparked debates for decades. Early in my career, an Hgb below 10 meant grabbing a blood bag—no questions asked. Today, we're wiser, and the evidence is richer. Dr. Samir Patel tackles this in a session that's all about balancing oxygen delivery with transfusion risks. He'll unpack the science of Hgb levels and tissue perfusion, diving into trials and guidelines that shape when we pull the transfusion trigger. I'll throw in a story of a mid-case Hgb drop to 7, where split-second decisions tested our team. We'll cover special cases—kids, the elderly, complex patients—and the risks of over- or under-transfusing. This is vital for perfusionists, surgeons, and ICU crews who live these choices daily. Walk away with a sharper eye for Hgb management, backed by Dr. Patel's expertise and my decades of real-time lessons.

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Significance of Coronary Artery Calcifications and Ischemic Electrocardiographic Changes Among Patients Undergoing Myocardial Perfusion Imaging

Dr. Geoffrey Funk, OPO CEO, joins Coffee & Compatibility to explain what NRP is, how it has impacted solid organ transplant allocation, and why some see it as controversial.

On this episode of JHLT: The Podcast, the Digital Media Editors invite lead author Jonathan E. Williams, MD, to discuss the paper, “Ex-Vivo Lung Perfusion: National Trends and Post-Transplant Outcomes.” Dr. Williams is a general surgery resident at the University of Michigan in Ann Arbor, with work focusing on contemporary lung preservation strategies, perfusion techniques, and particularly, EVLP. The episode explores: How the study explores the theory that EVLP use may increase transplant volumes Preserving data quality and other study limitations How to work in fields of study that sometimes yield as many questions as answers For the latest studies from JHLT, visit www.jhltonline.org/current, or, if you're an ISHLT member, access your Journal membership at www.ishlt.org/jhlt. Those on heart transplant teams should tune in again later this month for a study on sympathetic reinnervation in cardiac transplant recipients. Don't already get the Journal and want to read along? Join the International Society of Heart and Lung Transplantation at www.ishlt.org for a free subscription, or subscribe today at www.jhltonline.org.

Drs. Kat Talcott, Akshay Thomas, and Sarwar Zahid join the podcast for a journal club discussion covering three recent articles in major ophthalmology journals.Pneumatic Retinopexy IRIS Registry (https://www.ophthalmologyretina.org/article/S2468-6530(24)00526-8/fulltext)Macular Perfusion in Stable PDR (https://jamanetwork.com/journals/jamaophthalmology/fullarticle/2826881)Female Speaker Introductions (https://www.ajo.com/article/S0002-9394(24)00522-1/fulltext)Relevant Financial Disclosures: Dr. Sridhar has consulted for Alcon.You can claim CME credits for prior episodes via the AAO website. Visit https://www.aao.org/browse-multimedia?filter=Audi

Aujourd'hui, Barbara Lefebvre, Bruno Pomart, et Mourad Boudjellal débattent de l'actualité autour d'Alain Marschall et Olivier Truchot.

Article - The Impact of MRI-Based Advanced Neuroimaging on Neurooncologists'Clinical Decision-Making in Patients With Posttreatment High-GradeGlioma: A Prospective Survey-Based Study Atefeh Zeinoddini, MD, discusses the AJR article by Dagher et al. exploring the impact of advanced neuroimaging on management decisions after treatment for high-grade glioma, based on surveys of neurooncologists.

In this week's podcast, Neurology Today's editor-in-chief discusses data on the association between weight loss drugs and a rare type of optic neuropathy, ethical issues around normothermic regional perfusion, and how neurologists are onboarding and training advanced practice practitioners in comorbid cancer and stroke.