Passage of fluid through the circulatory or lymphatic system to an organ or tissue
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Join Jay Gunkelman, QEEGD (the man who has analyzed over 500,000 brain scans), and host Pete Jansons for another engaging NeuroNoodle Neurofeedback Podcast episode discussing neuroscience, psychology, mental health, and brain training.✅ Topic 1 Explained: Learn how brain temperature affects neurological functioning, cognition, and the risk of dysfunction at high core temperatures.✅ Topic 2 Deep Dive: We explore the controversial concept of “God frequencies” and the Schumann Resonances—natural earth-based electromagnetic frequencies often misused in marketing.✅ Topic 3 Insights: Jay shares fascinating EEG data from healing studies, showing entrainment between healer and subject using cross-frequency coupling and standing wave potentials.✅ Additional Topics:
On this episode of JHLT: The Podcast, the Digital Media Editors invite first author Gaurav Sharma, PhD, MBA, from the University of Texas Southwestern Medical Center in Dallas. Dr. Sharma discusses his paper, “Metabolic and transcriptomic insights into temperature controlled hypothermic preservation of human donor hearts.” The discussion explores: How donor hearts not offered or declined for transplantation responded in hypothermic preservation versus conventional static cold storage Potentially beneficial genetic signatures yielded by TCHP versus cold storage The surprising response of energy stores in the hearts to the different storage environments How multi-omic approaches could be applied to other organs For the latest studies from JHLT, visit www.jhltonline.org/current, or, if you're an ISHLT member, access your Journal membership at www.ishlt.org/jhlt. Don't already get the Journal and want to read along? Join the International Society of Heart and Lung Transplantation at www.ishlt.org for a free subscription, or subscribe today at www.jhltonline.org.
With Edward Hulten, Brown University, Providence, and Islam Shatla, University of Kansas Medical Center, Kansas City, USA. Link to edi
Join us for a continuation of our conversation with perfusionist Jordan Brimhall and Brandon Lowe, RRT, NPS, lead ECMO specialist at Emory in Atlanta. We discuss multidisciplinary collaboration in pediatric ECMO programs. Hosts: Deanna Todd Tzanetos, MD, MSCI (Norton Children's/UofL) and Chris Knoll, MD (Phoenix Children's). Guests Jordan Brimhall MS, CPP, FPP (Phoenix Children's) Brandon Lowe, RRT, NPS (Emory) Editing/Production (Deanna Todd Tzanetos, MD, MSCI)
This session dives into innovative machine perfusion techniques, advanced perfusates, and logistics breakthroughs aimed at extending organ viability and improving transplant outcomes. Packed with real-world case studies, expert insights, and interactive Q&A, this focused 1.2‑CEU webinar spotlights how modern technology is revolutionizing the way donor organs are preserved, transported, and ultimately saved.
Dive into the ethical dilemmas and controversies surrounding perfusion practices. This session, presented by Perfusion Education and streamed within the last month, tackles tough questions such as informed consent, allocation equity, risk-benefit analysis of experimental techniques, and real-world case studies. Essential for perfusionists, transplant professionals, and bioethicists, this discussion offers practical insights and stimulating debate to inform ethical decision-making in modern perfusion.
A comprehensive literature review on Normothermic Regional Perfusion (NRP) led by Samir Patel, MD, CCP, LP. Streamed on June 2, 2025, this session explores the latest research and emerging technologies in NRP, spotlighting its clinical applications, ethical considerations, and protocol development in perfusion practice. Ideal for perfusionists and transplant specialists, this episode packs 1.2 CEUs of expert insight into a field reshaping organ donation strategies.
Everything you wanted to know about perfusion but were afraid to ask. Join us for a conversation with Jordan Brimhall, MS, CCP, FPP Chief Perfusionist at Phoenix Children's Hospital. We discuss what really happens in the OR and what intensivists should know and understand about cardiopulmonary bypass. Hosts: Deanna Todd Tzanetos, MD, MSCI Norton Children's/ U of Louisville and Chris Knoll, MD Phoenix Children's Editor/Producer: Deanna Todd Tzanetos
Poiseuille's Law drives perfusion, and J. Basha, CCP, dissects why it's our physics Bible. He'll unpack flow's reliance on pressure, radius, length, and viscosity—key to circuits and patients. I'll recall early days when a tiny radius tweak tanked a case. You'll apply it to cannulas, tubing, and viscosity control via temp and Hgb. Calculate flows, predict pressures, fix problems fast. Perfusionists live this; OR teams peek into our world. After 40 years, I lean on Poiseuille daily—build your foundation here. Myocardial Protection Strategies: Why Do We Still See RV Dysfunction and Failure? Protecting the heart is cardiac surgery's core, yet RV dysfunction haunts us. J. Basha, CCP, digs into why and how to fight it. Basha will revisit cardioplegia basics—delivery, mixes, temps—then zero in on the RV's quirks and vulnerability. I'll share RV failures that taught me to watch it closer than the LV. Expect advanced moves: retrograde cardioplegia, RV tweaks, and handling pulmonary hypertension. Learn to spot and stop RV trouble from pre-op to post-op. Perfusionists need this; surgeons and anesthesiologists will align better with it. Crack the RV puzzle with us. Stand Your Ground: The AmSECT Guidelines on Hgb. Right or Wrong? Presenter: J. Basha, CCP, Audience Call-In. AmSECT's Hgb guidelines divide us—love 'em or hate 'em, they're up for debate. J. Basha, CCP, leads this call-in clash. Basha lays out the rules, the evidence, and the gripes. Then it's on: Do you stick to them or trust your gut? We'll argue universal thresholds, transfusion risks, and adjuncts like EPO. Bring your stance—students, pros, all voices count. Refine your practice in this showdown. Join us to stand your ground or find new footing.
Protecting the heart is cardiac surgery's core, yet RV dysfunction haunts us. J. Basha, CCP, digs into why and how to fight it. Basha will revisit cardioplegia basics—delivery, mixes, temps—then zero in on the RV's quirks and vulnerability. I'll share RV failures that taught me to watch it closer than the LV. Expect advanced moves: retrograde cardioplegia, RV tweaks, and handling pulmonary hypertension. Learn to spot and stop RV trouble from pre-op to post-op. Perfusionists need this; surgeons and anesthesiologists will align better with it. Crack the RV puzzle with us. What Is Reperfusion Injury and How Can It Be Avoided? Presenter: S. Patel, MD Reperfusion injury is the cruel twist of restoring flow only to harm more. Dr. S. Patel unravels this and offers fixes. He'll trace its roots—ischemia's setup, reperfusion's chaos of inflammation and cell death—and its RV toll. I'll tell of a case where cardioplegia wasn't enough, but smart moves won out. We'll cover controlled reperfusion, leukocyte filters, and medications such as adenosine, as well as new concepts like preconditioning. Perfusionists, surgeons, researchers—this is your playbook to dodge the paradox—master safe reperfusion with Patel and my 40-year lens.
Send us a textThe simple ice pack - a staple in both human and veterinary medicine for reducing pain and swelling. But what if this common therapy has unexpected consequences for healing? Soft tissue surgeon Dr. Vanna Dickerson and veterinary student Gabriella Hansen join us to discuss their fascinating research on how ice packs affect blood flow in canine skin.For years, surgeons have cautioned against using ice after delicate skin procedures like flaps and grafts, believing it might compromise blood flow. However, this advice lacked scientific backing until now. Through precise measurements using laser speckle contrast imaging, Dr. Dickerson and Hansen discovered that ice application reduces skin perfusion by 10-15% compared to baseline - and surprisingly, in some dogs, blood flow remained decreased even 15 minutes after the ice was removed.This groundbreaking work confirms what many surgeons suspected but couldn't prove, giving veterinarians evidence-based guidance for post-operative care decisions. Dr. Dickerson and Hansen emphasize that ice remains valuable for pain control in most situations, but surgeons should exercise caution in cases where even small perfusion decreases could jeopardize healing. For pet owners, understanding these nuances helps explain why your veterinarian might specifically recommend for or against icing in different scenarios.Beyond the clinical findings, Dr. Dickerson and Hansen offer valuable insights for veterinary students interested in research, encouraging them to find mentors and emphasizing that meaningful studies don't require complex laboratory setups. Their work exemplifies how asking simple questions about everyday practices can lead to significant improvements in patient care. Listen now to discover how this common therapy affects your pet's healing and what questions still remain for future investigation.AJVR article: https://doi.org/10.2460/ajvr.25.01.0023INTERESTED IN SUBMITTING YOUR MANUSCRIPT TO JAVMA ® OR AJVR ® ? JAVMA ® : https://avma.org/JAVMAAuthors AJVR ® : https://avma.org/AJVRAuthorsFOLLOW US:JAVMA ® : Facebook: Journal of the American Veterinary Medical Association - JAVMA | Facebook Instagram: JAVMA (@avma_javma) • Instagram photos and videos Twitter: JAVMA (@AVMAJAVMA) / Twitter AJVR ® : Facebook: American Journal of Veterinary Research - AJVR | Facebook Instagram: AJVR (@ajvroa) • Instagram photos and videos Twitter: AJVR (@AJVROA) / Twitter JAVMA ® and AJVR ® LinkedIn: https://linkedin.com/company/avma-journals
In this concluding episode of our deep dive into miniaturized perfusion systems, we tackle the most challenging aspect: implementing meaningful process analytical technology (PAT) at microscale while keeping costs realistic for high-throughput applications.Tom Valentin, group leader at CSEM for Automated Sample Handling, continues sharing CSEM's pioneering work in automated sample handling, revealing both the breakthrough opportunities and stubborn technical barriers that define the current state of small-scale perfusion development.Critical insights you'll gain from this episode:The PAT miniaturization challenge is about more than size: While optical density sensors work reasonably well for microbial cultures, mammalian cell applications demand more sophisticated solutions. Tom explains why viable cell density remains the "holy grail"—and how promising technologies from companies like IMEC and Inspec are pushing the boundaries, though cost-effective 96-well implementation remains elusiveSmart compromises can unlock practical solutions: Tom reveals why the industry may need to accept hybrid approaches—real-time pH and DO monitoring combined with once-daily viable cell density sampling. He also explains the unique challenges of sensor positioning in shaking deep-well plates where liquid dynamics create measurement complexitiesPartnership models that actually work for biotech innovation: Beyond the technical discussion, Tom outlines CSEM's proven collaboration approaches, including how Innoswiss funding can provide 50% cost reduction for development projects and why their 70% proposal success rate makes them an attractive R&D partner for both startups and established pharma companiesDiscover how bioprocessing is evolving - from high-throughput screening to digital twins and continuous manufacturing- in these expert-led episodes.Episode 155: From Process Bottlenecks to Seamless Production: How Continuous Bioprocessing Changes EverythingEpisodes 153-154: The Future of Bioprocessing: Industry 4.0, Digital Twins, and Continuous Manufacturing Strategies with Tiago MatosEpisodes 85-86: Bioprocess 4.0: Integrated Continuous Biomanufacturing with Massimo MorbidelliEpisodes 73-74: Bead-Based Assays: The Power of High-Throughput Screening with Sebastian GiehringConnect with Tom Valentin:LinkedIn: www.linkedin.com/in/tom-valentin-5bb9091bWebsite: www.csem.ch/enEmail: thomas.valentin@csem.chNext step:Book a free consultation to help you get started on any questions you may have about bioprocessing analytics: https://bruehlmann-consulting.com/callDevelop bioprocessing technologies better, faster, at a fraction of the cost with our 1:1 Strategy Call: The quickest and easiest way to excel biotech technology development. Book your call at www.bruehlmann-consulting.com/call/Support the show
In bioprocess development, the ability to rapidly screen conditions and predict scale-up performance can mean the difference between a successful therapy launch and costly delays. Today's Smart Biotech Scientist episode features Tom Valentin from CSEM, who's pioneering revolutionary approaches to miniaturized perfusion systems that could transform how we develop biologics.Tom is a group leader at CSEM for Automated Sample Handling within the Life Sciences and Industry 4.0 business unit. As a mechanical and biomedical engineer, he brings a unique cross-disciplinary perspective to solving bioprocessing's most challenging miniaturization problems.What makes this conversation essential listening:96-deep-well plates are revolutionizing perfusion development: Tom reveals how CSEM's innovative fluidic lids enable continuous medium exchange in 300-microliter volumes, potentially allowing up to 96 parallel perfusion experiments with automated liquid handlers and shaker incubatorsThree critical barriers still need solving: Despite the promise, Tom identifies the key technical challenges that must be overcome: ultra-low flow rate liquid handling (imagine exchanging 300 μL over 24 hours), effective cell retention in miniaturized systems, and cost-effective real-time biomonitoring that fits within well plate constraintsThe future of process development is automated and intelligent: From pressure-over-liquid systems to advanced sensor integration, Tom outlines how companies can achieve near-autonomous perfusion screening—but warns that current sensing limitations mean viable cell density monitoring remains the "holy grail" of small-scale perfusionThis isn't just about smaller equipment—it's about fundamentally changing how we approach process development. If you're working in cell culture optimization, process scale-up, or bioprocess automation, Tom's insights reveal both the tremendous opportunities and practical realities of implementing next-generation perfusion systems.For biotech professionals, staying ahead means embracing these high-throughput, data-rich models, allowing smarter, faster, and more predictive process development for the therapies of tomorrow.Discover how bioprocessing is evolving - from high-throughput screening to digital twins and continuous manufacturing- in these expert-led episodes.Episode 155: From Process Bottlenecks to Seamless Production: How Continuous Bioprocessing Changes EverythingEpisodes 153-154: The Future of Bioprocessing: Industry 4.0, Digital Twins, and Continuous Manufacturing Strategies with Tiago MatosEpisodes 85-86: Bioprocess 4.0: Integrated Continuous Biomanufacturing with Massimo MorbidelliEpisodes 73-74: Bead-Based Assays: The Power of High-Throughput Screening with Sebastian GiehringConnect with Tom Valentin:LinkedIn: www.linkedin.com/in/tom-valentin-5bb9091bWebsite: www.csem.ch/enEmail: thomas.valentin@csem.chNext step:Book a free consultation to help you get started on any questions you may have about bioprocessing analytics: https://bruehlmann-consulting.com/callDevelop bioprocessing technologies better, faster, at a fraction of the cost with our 1:1 Strategy Call: The quickest and easiest way to excel biotech technology development. Book your call at www.bruehlmann-consulting.com/call/Support the show
Host Sotirios Evangelou, MD, FSCCT is joined by Gianluca Pontone, MD, PhD, FSCCT to explore the evolving role of stress cardiac CT perfusion, from its early limitations to today's advanced scanners capable of capturing dynamic myocardial perfusion in just a few beats. Together, they discuss how this technique helps quantify blood flow and identify hypoperfused regions with precision.
Stand Your Ground - Raging Fireside Chat Presenter: J. Basha, CCP, Open to Audience After two days of transplant deep dives, J. Basha, CCP, hosts a two-hour open chat to wrestle with the big issues—and you're the spark. This is no passive wrap-up. Bring your takes on NRP ethics, OCS costs, or organ shortages. I'll share 40 years of perfusion fights, like pushing for innovation when tradition stalled. We'll spar over opt-out systems, machine perfusion's price tag, and allocation fairness. It's a chance to challenge, learn, and grow—perfusionists, coordinators, and anyone. Join the fireside fray to ignite real change.
Mastering NRP for Organ Donation Success NRP is rewriting organ donation rules, and Matt Warhoover, CCP, takes you inside this bold frontier over a two-hour session. Using ECMO or bypass, NRP restarts circulation after circulatory death to recover organs in situ. Warhoover will cover cannulation, perfusion, and the ethics of this gray zone. I'll weigh in on its promise—like turning DCD into multi-organ wins—and its hurdles. You'll compare it to standard methods and see its impact on the donor pool. Perfusionists will find new turf here; transplant pros will grasp its potential. Dive in to shape the future of donation.
Dr. Iyad Alnahhas interviews Dr. Peter LaViolette about his and his team's recent manuscript entitled: "Multi-Site Retrospective Analysis of Diffusion and Perfusion MRI Correlates to Glioma Characteristics Derived from Radio-Pathomic Maps", published online in Neuro-Oncology in February 2025.
Organ Availability for Transplant in the U.S. Presenter: S. Patel, MD Time: 10:00–11:00 Transplantation saves lives, but the organ shortage is a brutal bottleneck. Dr. S. Patel digs into this crisis, where over 100,000 wait and too many don't make it. He'll lay out the stats, policies, and ethics—why donor rates lag and who gets priority. I'll add my OR view: the highs of a transplant win, the lows when organs don't come. Dr. Patel will spotlight solutions like opt-out donation and perfusion's role in preservation. For perfusionists, this ties to our work; for healthcare pros, it's the big picture. Join us to see how we can close the gap—one organ, one patient at a time. Organ Procurement Techniques Presenter: S. Patel, MD Time: 11:00–12:00 Organ procurement is a high-wire act—surgery, timing, and teamwork in a race against ischemia. Dr. S. Patel unveils the process from donor consent to preservation. He'll detail organ-specific needs—kidneys versus hearts, livers needing extra care—and preservation tricks like cooling and solutions. I'll share a near-miss when a delayed flight tested our heart transport skills. You'll get the latest on machine perfusion, too. Perfusionists will prize this; surgeons and coordinators will sync better with it. This session arms you to keep organs viable for their next life. OCS (Organ Care System) Presenter: J. Basha, CCP Time: 12:00–13:00 The Organ Care System (OCS) is a transplant revolution, and J. Basha, CCP, shows why it's a game-changer I've seen work wonders. Unlike cold storage, OCS perfuses organs with warm, oxygenated blood, extending viability. Basha will explain its use for hearts, lungs, and livers, and how it rescues borderline organs. I'll recount an OCS save—a distant heart that beat strong thanks to this tech. Learn setup, monitoring, and troubleshooting to cut ischemic damage. Perfusionists will level up; transplant teams will broaden their reach. See why OCS is the future and how to wield it.
Stand Your Ground in the Raging Inferno Presenter: J. Basha, CCP, Open to Audience Participation After two packed days, we tie it together in a fiery roundtable led by J. Basha, CCP. This isn't a sit-back session—it's a gloves-off discussion of PerfWeb 100's topics, and you're in the ring. Basha will steer us through RAPP, Hgb thresholds, ultrafiltration, and fluid balance, but your questions and challenges fuel the fire. I'll toss in tales from 40 years, like when I stood firm against a crystalloid-happy surgeon. We'll debate: Is there a perfect Hgb cutoff? When is ultrafiltration too much? It's a chance to learn from peers, experts, and your grit. Students and pros alike will sharpen their edge here. Jump into the inferno—let's forge stronger practices together.
Benefits of Ultrafiltration Presenter: J. Basha, CCP Ultrafiltration hit perfusion like a lifeline, giving us control over fluid overload when diuretics alone wouldn't cut it. J. Basha, CCP, leads this session to show why it's a cornerstone of my practice after 40 years. Basha will break down how ultrafiltration strips out excess water and solutes via semi-permeable membranes, while keeping proteins and cells intact. It's not just fluid removal—it's precision, reducing edema and even inflammatory markers. I'll recall a heart failure case where ultrafiltration got us off bypass when the odds were grim. You'll learn the types (conventional, modified, zero-balance), how to weave it into your circuit, and how to dodge pitfalls like hypotension. Perfusionists will find this essential; OR teams will see its teamwork value. Join us to harness ultrafiltration's power for better outcomes. Assessment of Patient Fluid Balance and Status Presenters: S. Patel, MD, J. Basha, CCP Fluid balance is perfusion's quiet MVP—nail it, and the case flows; botch it, and you're in chaos. Dr. S. Patel and J. Basha team up to decode this critical skill over a two-hour deep dive. They'll cover the tools—CVP, PA pressures, TEE, bioimpedance—and how to read them amid bypass's wild fluid shifts. I'll share my go-to signs, like venous oxygen saturation shifts, that scream trouble early. Expect actionable strategies: pre-op prep, intra-op tweaks, and post-op stability, with tips like using albumin for oncotic pressure. This is for perfusionists, anesthesiologists, and surgeons—it's a team effort.
RAPP (Retrograde Autologous Prime) Presenter: Samir Patel, MD, Graduate Perfusionist Time: 14:00–15:00 Back when I started in perfusion, priming the cardiopulmonary bypass circuit meant dumping in crystalloid and hoping the patient wouldn't drown in fluid overload. Then RAPP—Retrograde Autologous Prime—came along and flipped the script. In this session, Dr. Samir Patel, a skilled graduate perfusionist, dives into this game-changing technique that uses the patient's own blood to prime the circuit, slashing hemodilution and preserving hematocrit. Dr. Patel will walk you through the nuts and bolts: draining venous blood, displacing crystalloid, and reinfusing—all while keeping the patient stable. I'll share a standout case where RAPP saved the day for a Jehovah's Witness patient who refused transfusions—proof of its worth. You'll master cannula placement, pressure control, and timing, plus learn how RAPP cuts transfusion rates and post-op complications. Whether you're a newbie or a veteran, this lecture will sharpen your skills and show why RAPP's a must-have in my toolkit Hgb Thresholds Presenter: Samir Patel, MD, Graduate Perfusionist Time: 15:00–16:00 Hemoglobin thresholds have sparked debates for decades. Early in my career, an Hgb below 10 meant grabbing a blood bag—no questions asked. Today, we're wiser, and the evidence is richer. Dr. Samir Patel tackles this in a session that's all about balancing oxygen delivery with transfusion risks. He'll unpack the science of Hgb levels and tissue perfusion, diving into trials and guidelines that shape when we pull the transfusion trigger. I'll throw in a story of a mid-case Hgb drop to 7, where split-second decisions tested our team. We'll cover special cases—kids, the elderly, complex patients—and the risks of over- or under-transfusing. This is vital for perfusionists, surgeons, and ICU crews who live these choices daily. Walk away with a sharper eye for Hgb management, backed by Dr. Patel's expertise and my decades of real-time lessons.
Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Significance of Coronary Artery Calcifications and Ischemic Electrocardiographic Changes Among Patients Undergoing Myocardial Perfusion Imaging
Dr. Geoffrey Funk, OPO CEO, joins Coffee & Compatibility to explain what NRP is, how it has impacted solid organ transplant allocation, and why some see it as controversial.
On this episode of JHLT: The Podcast, the Digital Media Editors invite lead author Jonathan E. Williams, MD, to discuss the paper, “Ex-Vivo Lung Perfusion: National Trends and Post-Transplant Outcomes.” Dr. Williams is a general surgery resident at the University of Michigan in Ann Arbor, with work focusing on contemporary lung preservation strategies, perfusion techniques, and particularly, EVLP. The episode explores: How the study explores the theory that EVLP use may increase transplant volumes Preserving data quality and other study limitations How to work in fields of study that sometimes yield as many questions as answers For the latest studies from JHLT, visit www.jhltonline.org/current, or, if you're an ISHLT member, access your Journal membership at www.ishlt.org/jhlt. Those on heart transplant teams should tune in again later this month for a study on sympathetic reinnervation in cardiac transplant recipients. Don't already get the Journal and want to read along? Join the International Society of Heart and Lung Transplantation at www.ishlt.org for a free subscription, or subscribe today at www.jhltonline.org.
Drs. Kat Talcott, Akshay Thomas, and Sarwar Zahid join the podcast for a journal club discussion covering three recent articles in major ophthalmology journals.Pneumatic Retinopexy IRIS Registry (https://www.ophthalmologyretina.org/article/S2468-6530(24)00526-8/fulltext)Macular Perfusion in Stable PDR (https://jamanetwork.com/journals/jamaophthalmology/fullarticle/2826881)Female Speaker Introductions (https://www.ajo.com/article/S0002-9394(24)00522-1/fulltext)Relevant Financial Disclosures: Dr. Sridhar has consulted for Alcon.You can claim CME credits for prior episodes via the AAO website. Visit https://www.aao.org/browse-multimedia?filter=Audi
Aujourd'hui, Barbara Lefebvre, Bruno Pomart, et Mourad Boudjellal débattent de l'actualité autour d'Alain Marschall et Olivier Truchot.
Abdullah Al-Abcha, MD, social media editor of JACC: Cardiovascular Interventions, and Sung Gyun Ahn, MD, PhD, discuss a recently published original research paper reporting the outcomes of failed thrombus aspiration in patients with STEMI and large thrombus burden.
Article - The Impact of MRI-Based Advanced Neuroimaging on Neurooncologists'Clinical Decision-Making in Patients With Posttreatment High-GradeGlioma: A Prospective Survey-Based Study Atefeh Zeinoddini, MD, discusses the AJR article by Dagher et al. exploring the impact of advanced neuroimaging on management decisions after treatment for high-grade glioma, based on surveys of neurooncologists.
In this week's podcast, Neurology Today's editor-in-chief discusses data on the association between weight loss drugs and a rare type of optic neuropathy, ethical issues around normothermic regional perfusion, and how neurologists are onboarding and training advanced practice practitioners in comorbid cancer and stroke.
Audio Commentary by Dr. Valentin Fuster, Emeritus Editor in Chief
Joining our hosts this month are the esteemed ‘Ex Vivo Organ Perfusion' experts, Edris Mahtab Leiden University Medical Center, The Netherlands) and Andreas Zuckermann (Medical University of Vienna, Austria). In this episode, Can Gollmann-Tepeköylü and Miia L Lehtinen discuss how these guests have influenced the developing field of heart and lung transplantation. Listeners can gain an understanding of the evolving difficulties associated with transplantation, and how innovative techniques are improving organ preservation. Listeners are also encouraged to take a look at a related MMCTS article demonstrating relevant techniques.
Aujourd'hui, Flora Ghebali, Didier Giraud et Stéphane Manigold débattent de l'actualité autour d'Alain Marschall et Olivier Truchot.
Biomedical Engineer Margot Damaser meets Research Scientist Petra de Graaf and Pharmacologist Pradeep Tyagi to discuss their captivating ICS abstract presentations on urethral structure disease studied using a human urethra-on-a-chip and the interaction between perfusion and permeability in bladder inflammation.Human urethra-on-a-chip to study urethral sticture diseaseProbing The Interplay of Perfusion and Permeability in Bladder Inflammation Early registration for ICS 2024 Madrid is now open at www.ics.org/2024The ICS annual meeting is the must-attend, multidisciplinary event for clinical and research scientists interested in: Urology Urogynaecology Female and functional urology Gynaecology Bowel dysfunction Neurourology Pure and applied science Physiotherapy Nursing Geriatrics The ICS 2024 Madrid conference fosters collaboration between all disciplines involved in continence care.
In this episode, we review the high-yield topic of Diffusion-Limited and Perfusion-Limited Gas Exchange from the Respiratory section. Follow Medbullets on social media: Facebook: www.facebook.com/medbullets Instagram: www.instagram.com/medbulletsofficial Twitter: www.twitter.com/medbullets --- Send in a voice message: https://podcasters.spotify.com/pod/show/medbulletsstep1/message
With Juerg Schwitter, Ambra Masi & Panagiotis Antiochos, University Hospital Lausanne, Lausanne - Switzerland. Link to editorial Link to paper
Integration of the PrismaFlex CRRT Machine into Your ECMO Circuit: A Comprehensive Review of Pressure/Flow Relationships, Challenges, and Solutions. J. Basha, CCP, promises an in-depth review of integrating the PrismaFlex Continuous Renal Replacement Therapy (CRRT) machine with Extracorporeal Membrane Oxygenation (ECMO) circuits. This comprehensive seminar will cover the technical nuances, benefits, and potential complications of such integration, emphasizing the management of pressure and flow dynamics to ensure optimal performance and patient safety. Participants will learn: The fundamentals of ECMO and CRRT technologies and the rationale behind their integration. Detailed analysis of pressure and flow relationships within the combined ECMO-CRRT circuit, highlighting key parameters for successful operation. Common challenges encountered during integration and practical solutions, derived from real-world case studies and expert experience. Best practices for monitoring and adjusting the integrated system to prevent complications and enhance therapeutic efficacy. This webinar is designed for perfusionists at all stages of their careers, from novices seeking to broaden their knowledge base to seasoned professionals aiming to update their skills with the latest advancements in perfusion technology and practices. It will also benefit cardiac surgeons, anesthesiologists, and intensive care professionals involved in the care of patients undergoing cardiac surgery and critical care management.
Our day begins with a focused exploration into the management of hyperkalemia following the release of aortic cross clamping, a critical phase during cardiac surgery where precision in fluid management can dictate patient outcomes. Led by J. Basha, CCP, a renowned expert in the field of perfusion, this session will dissect the efficacy of Zero-Balance Ultrafiltration (Z-BUF) in managing hyperkalemia, an often-challenging condition that can lead to severe cardiac complications if not managed with expertise and care. Perfusion has become much safer than years past, however, it remains fraught with dangers. Joe discusses 4 cases that nearly ended in disaster and would likely have been career ending. Despite advancements in safety, the domain of perfusion continues to present significant challenges and risks. In this insightful webinar, Joe Basha will share personal experiences from four distinct scenarios that teetered on the brink of disaster. These narratives not only underscore the inherent dangers in perfusion but also highlight the crucial learnings and preventive strategies that safeguard against potential career-ending mistakes. This session promises to be an invaluable learning experience for perfusionists at any stage in their career, offering lessons in vigilance, preparedness, and the importance of learning from near misses.
In this week's episode of "On Pump" Podcast, we're wrapping up Perfusion Week with a pulse—literally! Join us as we delve into the dynamic world of perfusion with a special guest, Doug Vincent, a trailblazing figure in medical device innovation and the brains behind the VentriFlo, the world's first pulsatile pump. As we explore the intricacies of perfusion, we'll uncover the vital role pulsatile pumps play in mimicking the natural heartbeat and improving patient outcomes. Doug Vincent brings a wealth of expertise to the table, shedding light on the groundbreaking advancements in perfusion technology and the transformative impact it has on patient care. From the evolution of perfusion techniques to the challenges and triumphs of developing pulsatile pumps, this episode promises an insightful discussion into the pulse of perfusion. Join us as we unravel the intricacies of this life-saving technology and gain a deeper understanding of its significance in the field of medicine. Tune in to "On Pump" Podcast as we embark on a pulsating journey through the world of perfusion with Doug Vincent, a visionary in medical innovation, and uncover the heartbeat of progress in patient care.
MedLink Neurology Podcast is delighted to feature selected episodes from BrainWaves, courtesy of James E Siegler MD, its originator and host. BrainWaves is an academic audio podcast whose mission is to educate medical providers through clinical cases and topical reviews in neurology, medicine, and the humanities. Episodes originally aired from 2016 to 2021. Originally released: May 16, 2019 It would be an understatement to say that endovascular thrombectomy has revolutionized acute stroke management. As of 2018, the American Heart Association recommends treatment up to 24 hours after time last seen normal for select patients. This week on the BrainWaves podcast, Dr. Tudor Jovin--PI for the DAWN and REVASCAT clinical trials--summarizes the history of thrombectomy trials and what it is about our current strategies that have breathed new life into a technique that has historically fizzled. Produced by James E Siegler and Jesse Thon. Music courtesy of Cuicuitte, Coldnoise, Medyn, Jon Watts, Lee Rosevere, and Mystery Mammal. Sound effects by Mike Koenig and Daniel Simion. BrainWaves' podcasts and online content are intended for medical education only and should not be used for clinical decision-making. Be sure to follow us on Twitter (now X) @brainwavesaudio for the latest updates to the podcast. REFERENCES Campbell BC, Majoie CB, Albers GW, et al. Penumbral imaging and functional outcome in patients with anterior circulation ischaemic stroke treated with endovascular thrombectomy versus medical therapy: a meta-analysis of individual patient-level data. Lancet Neurol 2019;18(1):46-55. Erratum in: Lancet Neurol 2019 Mar;18(3):e2. PMID 30413385Goyal M, Menon BK, van Zwam WH, et al. Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials. Lancet 2016;387(10029):1723-31. PMID 26898852Gross BA, Jadhav AP, Jankowitz BT, Jovin TG. The ongoing revolution in thrombectomy: expanding inclusion criteria to larger cores. World Neurosurg 2018;120:393-94. PMID 30292027Heit JJ, Wintermark M. Perfusion computed tomography for the evaluation of acute ischemic stroke: strengths and pitfalls. Stroke 2016;47(4):1153-8. PMID 26965849Jadhav AP, Molyneaux BJ, Hill MD, Jovin TG. Care of the post-thrombectomy patient. Stroke 2018;49(11):2801-07. PMID 30355218Konstas AA, Goldmakher GV, Lee TY, Lev MH. Theoretic basis and technical implementations of CT perfusion in acute ischemic stroke, part 2: technical implementations. AJNR Am J Neuroradiol 2009;30(5):885-92. PMID 19299489Nogueira RG, Jadhav AP, Haussen DC, et al. Thrombectomy 6 to 24 hours after stroke with a mismatch between deficit and infarct. N Engl J Med 2018;378(1):11-21. PMID 29129157Román LS, Menon BK, Blasco J, et al. Imaging features and safety and efficacy of endovascular stroke treatment: a meta-analysis of individual patient-level data. Lancet Neurol 2018;17(10):895-904. PMID 30264728 We believe that the principles expressed or implied in the podcast remain valid, but certain details may be superseded by evolving knowledge since the episode's original release date.
Explore the intricate world of perfusion and its sustainability challenges in the part 2 of this episode. Dive into the operational side of managing vast quantities of media production and storage, and discover smart strategies to address these challenges.Jochen Sieck, Director of Cell Culture Media and Process Development at Merck Life Science, discusses the distinction between facility designs for batch and perfusion bioreactors, shedding light on the need for extensive tank farms to support perfusion.Key Insights:Explore the success of automated perfusion media preparation at the lab scale and its scaling up to a 500L capacity.Discover how advancements in small-scale perfusion operations are supercharging the perfusion process development.Get practical steps for developing a cost-efficient perfusion process.Tune in to discover how perfusion processes are revolutionizing the biotech industry and contributing to a more sustainable future.Connect with Jochen Sieck:LinkedIn: https://www.linkedin.com/in/jochenbsieckACTIP Fellowship award: https://www.actip.org/fellowshipResources:Perfusion Cell Culture Processes for Biopharmaceuticals by Moritz Wolf, Jean-Marc Bielser, and Massimo Morbidelli: https://www.cambridge.org/core/books/perfusion-cell-culture-processes-for-biopharmaceuticals/5C650AD26D52B2435E7796D382ECE5DANext Step:Elevate your biologics development strategy — Schedule your free assessment now: https://bruehlmann-consulting.com
Explore perfusion processes and sustainability with our guest, Jochen Sieck, Director of Cell Culture Media and Process Development at Merck Life Science.Learn about the evolution of perfusion methodologies, its historical roots in addressing product stability, and its recent return to continuous and integrated manufacturing.Jochen discusses the economic and strategic reasons behind perfusion's resurgence, emphasizing the need for flexible, smaller-scale facilities.Key Learnings:Gain insight into the environmental impact of traditional facilities and the potential benefits of alternatives.Dive deep into the balance of cost, productivity, and sustainability in media consumption.Discover strategies for optimizing perfusion rates and sustainability.Get ready to expand your understanding of perfusion processes, sustainability, and the delicate dance between economics and environmental consciousness.Connect with Jochen Sieck:LinkedIn: https://www.linkedin.com/in/jochenbsieckACTIP Fellowship award: https://www.actip.org/fellowshipResources:Perfusion Cell Culture Processes for Biopharmaceuticals by Moritz Wolf, Jean-Marc Bielser, and Massimo Morbidelli: https://www.cambridge.org/core/books/perfusion-cell-culture-processes-for-biopharmaceuticals/5C650AD26D52B2435E7796D382ECE5DANext Step:Elevate your biologics development strategy — Schedule your free assessment now: https://bruehlmann-consulting.com
durée : 00:58:43 - Entendez-vous l'éco ? - par : Tiphaine de Rocquigny, Aliette Hovine - Après une discussion avec Catherine Malabou sur la notion de propriété privée, nous reviendrons sur les raisons du succès de l'industrie française de l'armement, devenue deuxième exportatrice mondiale d'armes. - invités : Catherine Malabou Philosophe, professeure de philosophie au « Centre for Research in Modern European Philosophy » à l'Université de Kingston au Royaume-Uni; Julien Malizard Titulaire adjoint de la chaire Économie de la défense de l'IHEDN (Institut des Hautes Études de Défense Nationale)
Welcome to the Nurse Dose Podcast! In this episode, join your host Sean for the first installment of the ACLS Deep Dive series, where we embark on an enlightening journey into the intricate world of Advanced Cardiovascular Life Support. In this episode, Sean delves into the critical concept of Coronary Perfusion Pressure (CPP). As a seasoned healthcare professional, Sean unravels the layers of this vital component in resuscitation scenarios, offering an in-depth exploration of its significance in managing cardiac emergencies. Tune in as Sean breaks down the key elements of Coronary Perfusion Pressure, shedding light on its role in maintaining adequate blood flow to the heart during life-threatening situations. Drawing from his wealth of experience, Sean provides practical insights and real-world applications to empower healthcare providers with the knowledge needed to optimize patient outcomes. Whether you're a seasoned healthcare professional or a curious listener eager to understand the intricacies of ACLS, this episode promises to be an informative and engaging start to the Nurse Dose Podcast's ACLS Deep Dive series. Join Sean on this educational adventure as he demystifies Coronary Perfusion Pressure, paving the way for a deeper understanding of life-saving practices in the world of advanced cardiac care. ICU Resources Instagram Website (free resource if you sign up for mailing list!) This podcast is intended for informational and educational purposes only. It is not intended to provide medical advice or to substitute for the advice provided by your own physician or other medical professionals. The information contained herein is not intended to diagnose, treat, cure, or prevent any disease. If you have any concerns or questions about your health, you should always consult with a physician or other healthcare professional. The opinions expressed in this podcast are those of the host and guests and do not necessarily reflect the views of any medical institution, organization, or employer. By listening to this podcast, you agree to hold harmless the host, guests, and any associated parties from any and all liability or damages arising from your use of the information provided.
Commentary by Dr. Valentin Fuster
In this enlightening episode of the Nurse Dose Podcast, we dive deep into the cutting-edge world of organ perfusion and xenotransplantation with our special guest. Join us as we explore the remarkable advancements that are revolutionizing the field of organ donation and transplantation. Organ perfusion, the process of maintaining organs outside the human body while preserving their vitality, is a game-changer in the world of transplantation. Our expert guest walks us through the intricate details of this technology, from the science behind it to the incredible impact it's having on the availability of life-saving organs. But that's not all – we also venture into the fascinating realm of xenotransplantation. Xenotransplantation explores the possibility of using organs from non-human animals for transplantation into humans. We'll discuss the challenges, the promise, and the ethical considerations surrounding this bold approach to solving the organ shortage crisis. Join us for an episode that will leave you both informed and inspired, as we examine the innovations that are reshaping the landscape of transplantation. Whether you're a healthcare professional, a patient, or simply curious about the future of medicine, this conversation is not to be missed. Tune in to the Nurse Dose Podcast and be a part of the future of organ transplantation! ICU resources and cheat sheets are available at nursedosepodcast.etsy.com Follow me on Instagram and TikTok: @nursedosepodcast Join the mailing list and get a free resource! www.nursedose.org This podcast is intended for informational and educational purposes only. It is not intended to provide medical advice or to substitute for the advice provided by your own physician or other medical professionals. The information contained herein is not intended to diagnose, treat, cure, or prevent any disease. If you have any concerns or questions about your health, you should always consult with a physician or other healthcare professional. The opinions expressed in this podcast are those of the host and guests and do not necessarily reflect the views of any medical institution, organization, or employer. By listening to this podcast, you agree to hold harmless the host, guests, and any associated parties from any and all liability or damages arising from your use of the information provided.
Commentary by Dr. Valentin Fuster
In this exciting episode of "On Pump," we sit down with Liv Burch, a dynamic entrepreneur and the brilliant budding author of "Beating Heart: Your Complete Guide to Perfusion Education and Success." Liv's wealth of knowledge and passion for perfusion make her a leading authority in the field, and she's here to share her insights with our listeners.Aspiring perfusionists and anyone intrigued by a rewarding career in medicine won't want to miss this interview. Liv Burch offers invaluable advice on how to navigate the world of perfusion, drawing from her own experiences and expertise. Her journey is a testament to the possibilities within this fascinating and life-saving profession.But that's not all! Don't forget to visit Livperfusion.com, where you can purchase Liv's groundbreaking book, "Beating Heart." Use the exclusive code "ONPUMP" at checkout for a 15% discount. It's the ultimate resource for anyone looking to kickstart or advance their career in perfusion.Additionally, we've got something special for our Spotify listeners. Be sure to check out our new Q&A interactive poll when you tune in. Your answers could be featured in future episodes, and your curiosity might just be the catalyst for someone else's passion in perfusion.Join us for this enlightening conversation with Live Burch, and take your first steps toward a rewarding career in perfusion. Subscribe to "On Pump" today and get ready to be inspired.
In this captivating episode, we embark on a fascinating journey into the world of meditation and its potential as a treatment and preventive measure for Alzheimer's disease. While meditation is widely recognized for its ability to reduce stress, depression, and anxiety, it turns out there may be even more to this ancient practice. Join us as we delve deeper into the remarkable imaging studies that prove structural changes in the brains of regular meditators. These changes not only contribute to enhanced cognitive behavior and memory but also serve as a protective mechanism against the onset of dementia. However, the burning question remains: How significant is this data? By exploring the methodologies employed in these studies and understanding the implications of the results, we aim to shed light on the true potential of meditation in combating Alzheimer's. Although we acknowledge that we are still in the early stages of research, it becomes clear that meditation is a wonderful intervention worth recommending. Tune in as we explore the captivating intersection of meditation, brain health, and the fight against Alzheimer's disease. Don't miss this enlightening episode of the Wild Health Podcast! Refernces: Effects of Meditation on Structural Changes of the Brain in Patients With Mild Cognitive Impairment or Alzheimer's Disease Dementia. Front. Hum. Neurosci., 12 November 2021 Sec. Cognitive Neuroscience https://www.frontiersin.org/articles/10.3389/fnhum.2021.728993/full Effect of an 18-Month Meditation Training on Regional Brain Volume and Perfusion in Older Adults. JAMA Neurol. 2022;79(11):1165-1174. doi:10.1001/jamaneurol.2022.3185 https://jamanetwork.com/journals/jamaneurology/fullarticle/2796818
In this episode, our transplant team will discuss an article that reviews normothermic machine perfusion including how it has evolved over the years, current benefits and challenges, as well as future directions. Learning objectives: · Understand the current role of machine perfusion in renal transplantation · Describe historical and current limitations of machine perfusion for abdominal organ transplantation · Review the benefits of improved and expanded preservation techniques References: 1. Hamelink, T. L., Ogurlu, B., de Beule, J., Lantinga, V. A., Pool, M. B. F., Venema, L. H., Leuvenink, H. G. D., Jochmans, I., & Moers, C. (2022). Renal Normothermic Machine Perfusion: The Road Toward Clinical Implementation of a Promising Pretransplant Organ Assessment Tool. In Transplantation (Vol. 106, Issue 2). https://doi.org/10.1097/TP.0000000000003817 **Specialty team application link - https://forms.gle/DwrRcMYDaP3a3LaQA Please email hello@behindtheknife.org with any questions. Please visit https://behindtheknife.org to access other high-yield surgical education podcasts, videos and more. If you liked this episode, check out other transplant episode here: https://behindtheknife.org/podcast-category/transplant/