Podcasts about Perfusion

This episode explores tadalafil (Cialis) as a potential longevity drug, though no randomized human trials prove it extends lifespan. Cialis works by blocking PDE5, enhancing nitric oxide signaling, and improving blood flow through vasodilation. Originally approved for pulmonary hypertension, it's also used for erectile dysfunction and BPH. Its 36-hour half-life makes it superior to Viagra for continuous longevity effects.   The host frames vascular aging and endothelial dysfunction as key drivers of age-related diseases (heart disease, stroke, dementia, kidney disease). Observational data shows Cialis users have 44% lower mortality, fewer cardiovascular events, reduced dementia risk, and lower mortality in diabetics. Additional benefits include improved cardiac function, reduced infarct size, arrhythmia suppression, and regression of left ventricular hypertrophy. A 2024 meta-analysis found it lowers hemoglobin A1C, possibly via improved microvascular perfusion, insulin sensitivity, and mitochondrial function.   Cialis crosses the blood-brain barrier and may improve neurovascular coupling and hippocampal plasticity, potentially benefiting those with or at risk of dementia. Safety is generally good with long-term daily use (2.5–5 mg), though cautions include avoiding use with nitrates, low blood pressure, or certain retinal disorders. Common side effects are headache, nasal congestion, and acid reflux. The host recommends consulting a doctor and references potential synergy with telmisartan.   Tadalafil (Cialis) — MedlinePlus drug info: [https://medlineplus.gov/druginfo/meds/a604008.html](https://medlineplus.gov/druginfo/meds/a604008.html) Sildenafil (Viagra) — MedlinePlus drug info: [https://medlineplus.gov/druginfo/meds/a699015.html](https://medlineplus.gov/druginfo/meds/a699015.html)   Key mechanisms mentioned Nitric Oxide (NO) — NCBI Bookshelf: [https://www.ncbi.nlm.nih.gov/books/NBK554485/](https://www.ncbi.nlm.nih.gov/books/NBK554485/) Cyclic GMP (cGMP) — NCBI Bookshelf: [https://www.ncbi.nlm.nih.gov/books/NBK542234/](https://www.ncbi.nlm.nih.gov/books/NBK542234/)   Conditions mentioned in the episode Benign Prostatic Hyperplasia (BPH) — MedlinePlus: [https://medlineplus.gov/benignprostatichyperplasia.html](https://medlineplus.gov/benignprostatichyperplasia.html) Pulmonary Arterial Hypertension (PAH) — MedlinePlus: [https://medlineplus.gov/pulmonaryhypertension.html](https://medlineplus.gov/pulmonaryhypertension.html)   Blood pressure drug mentioned Telmisartan — MedlinePlus drug info: [https://medlineplus.gov/druginfo/meds/a601249.html](https://medlineplus.gov/druginfo/meds/a601249.html)   Other longevity / comparison drugs mentioned Metformin — MedlinePlus drug info: [https://medlineplus.gov/druginfo/meds/a696005.html](https://medlineplus.gov/druginfo/meds/a696005.html) Sirolimus (Rapamycin) — MedlinePlus drug info: [https://medlineplus.gov/druginfo/meds/a602026.html](https://medlineplus.gov/druginfo/meds/a602026.html)   Side-effect helper mentioned Ibuprofen (Advil) — MedlinePlus drug info: [https://medlineplus.gov/druginfo/meds/a682159.html](https://medlineplus.gov/druginfo/meds/a682159.html)   Dementia meds mentioned Donepezil (Aricept) — MedlinePlus drug info: [https://medlineplus.gov/druginfo/meds/a697032.html](https://medlineplus.gov/druginfo/meds/a697032.html) Amantadine — MedlinePlus drug info: [https://medlineplus.gov/druginfo/meds/a682064.html](https://medlineplus.gov/druginfo/meds/a682064.html)   Lab markers mentioned Hemoglobin A1C (HbA1c) test — MedlinePlus lab test: [https://medlineplus.gov/lab-tests/hemoglobin-a1c-hba1c-test/](https://medlineplus.gov/lab-tests/hemoglobin-a1c-hba1c-test/) Insulin in blood test — MedlinePlus lab test: [https://medlineplus.gov/lab-tests/insulin-in-blood/](https://medlineplus.gov/lab-tests/insulin-in-blood/)   People referenced (where the claims were mentioned) Huberman Lab (Dr. Andrew Huberman) — site: [https://www.hubermanlab.com/](https://www.hubermanlab.com/) Clip about low-dose tadalafil (2.5–5mg) — X post: [https://x.com/tbpn/status/2022350426394534334](https://x.com/tbpn/status/2022350426394534334) Bryan Johnson (Blueprint) — site: [https://blueprint.bryanjohnson.com/](https://blueprint.bryanjohnson.com/) Dr. David Sinclair (Harvard profile) — site: [https://sinclair.hms.harvard.edu/people/david-sinclair](https://sinclair.hms.harvard.edu/people/david-sinclair)   Show Notes   00:00 Welcome to the Hart2Heart Podcast. 01:56 What Cialis Is: PDE5 Inhibition, cGMP & Nitric Oxide Explained 03:43 Approved Uses & Origin Story: Pulmonary Hypertension, ED, and BPH 05:33 Why Cialis Over Viagra: 36-Hour Half-Life & 24/7 Vascular Benefits 06:52 Vascular Aging 101: Endothelium, Perfusion, and Why It Drives Disease 11:14 What the Human Data Shows: Observational Evidence for Mortality, CVD & Dementia 13:04 Mechanisms Deep Dive: Heart Protection, Heart Failure, and Anti-Atherosclerosis 15:02 Cialis for Diabetics: Lowering A1C and Improving Insulin Sensitivity 16:21 Brain Effects: Blood–Brain Barrier, Neurovascular Coupling & Dementia Potential 18:21 Safety, Who Should Avoid It, and Daily Longevity Dosing (2.5–5 mg) + Wrap-Up   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.   Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart

Send a textKann eine transösophageale Echokardiographie (TEE) bereits präklinisch während laufender Reanimation eingesetzt werden, ohne die CPR-Qualität zu beeinträchtigen? In dieser Episode analysieren wir die erste randomisierte kontrollierte Pilotstudie zur prähospitalen TEE bei außerklinischem Herz-Kreislauf-Stillstand (OHCA) und diskutieren Effekte auf Chest Compression Fraction, EtCO₂ sowie diagnostische und prozedurale Konsequenzen.Katzenschlager S, Kaltschmidt N, Dietrich M, et al.Prehospital transesophageal echocardiography versus conventional advanced life support in out-of-hospital cardiac arrest (PHTEE–OHCA): a randomized controlled pilot study.Critical Care. 2026;30:45.DOI: 10.1186/s13054-025-05805-w Die Qualität der Thoraxkompressionen ist ein zentraler Determinant des Outcomes beim außerklinischen Herz-Kreislauf-Stillstand (OHCA). Während transthorakale Echokardiographie (TTE) in Leitlinien empfohlen wird, kann sie zu prolongierten Hands-off-Phasen führen. Die transösophageale Echokardiographie (TEE) erlaubt dagegen Bildgebung unter laufender Kompression und könnte sowohl die Reanimationsqualität als auch die Identifikation reversibler Ursachen verbessern.In dieser randomisierten, kontrollierten Pilotstudie wurden 32 erwachsene Patient:innen mit nicht-traumatischem OHCA in einem arztbesetzten zweistufigen Rettungsdienstsystem 1:1 zu Standard-ALS oder ALS plus TEE randomisiert. Primäre Endpunkte waren Hands-off-Zeit und Chest Compression Fraction (CCF). Sekundäre Endpunkte umfassten ROSC bei Krankenhausaufnahme, Überleben bis Entlassung, neurologisches Outcome (CPC 1–2), EtCO₂-Verlauf sowie TEE-basierte diagnostische Befunde.Die mediane Hands-off-Zeit betrug in beiden Gruppen 4 Sekunden; es zeigte sich kein signifikanter Unterschied. Die CCF war jedoch signifikant höher in der TEE-Gruppe (96,2 % vs. 91,6 %; mittlere Differenz 4,6 %, 95 %-KI 2,5–6,7; p < 0,001). EtCO₂-Werte lagen ebenfalls signifikant höher in der TEE-Gruppe (+7 mmHg; 95 %-KI 4–10; p < 0,001), was auf effektivere Perfusion hinweisen könnte.In der as-treated-Analyse wurden bei 23 % der Fälle eine initial falsche Area of Maximal Compression (AMC) sowie bei 14 % eine inadäquate Kompressionstiefe identifiziert und unter TEE-Guidance korrigiert. Perikardergüsse wurden in 23 % diagnostiziert, davon 60 % hämodynamisch relevant (Tamponade). In allen eCPR-Fällen war eine Visualisierung von Führungsdrähten und Kanülenlage möglich. TEE-bedingte Komplikationen wurden nicht beobachtet.Die Studie zeigt, dass prähospitale TEE technisch machbar ist und CPR-Metriken nicht beeinträchtigt. Darüber hinaus liefert sie relevante diagnostische Informationen und ermöglicht prozedurale Guidance. Aufgrund der geringen Fallzahl ist jedoch keine Aussage zu Überlebensvorteilen möglich.

Send us a textDie Steuerung des mittleren arteriellen Drucks und des Herzzeitvolumens ist zentral in der Therapie des septischen Schocks – doch garantiert makrohämodynamische Stabilität auch eine adäquate Mikrozirkulation? In dieser Episode diskutieren wir einen aktuellen Scoping Review aus Critical Care Medicine, der systematisch untersucht, wie vasoaktive Medikamente die Mikrozirkulation im septischen Schock beeinflussen.Sathianathan S, Sachar S, Berro J, et al.Vasoactive Medications and the Microcirculation in Septic Shock: A Scoping Review.Critical Care Medicine. 2026;54:XX–XX.DOI: 10.1097/CCM.0000000000007016Die Mikrozirkulation spielt eine zentrale Rolle für die Gewebeoxygenierung und Organfunktion im septischen Schock. Trotz erfolgreicher Normalisierung globaler hämodynamischer Parameter wie mittlerem arteriellem Druck (MAP) oder Herzindex bleibt die mikrovaskuläre Perfusion häufig gestört – ein Phänomen, das als Verlust der hämodynamischen Kohärenz beschrieben wird.In diesem Scoping Review analysierten Sathianathan et al. 33 klinische Studien, die den Einfluss vasoaktiver Medikamente auf die Mikrozirkulation bei erwachsenen Patient:innen mit septischem Schock untersuchten. Eingeschlossen wurden Studien mit direkter mikrozirkulatorischer Messung mittels sublingualer Videomikroskopie (SDF/OPS), Laser-Doppler-Flowmetrie, Nahinfrarotspektroskopie, Magen-Tonometrie oder Kapillarfüllzeit. Die Studien zeigten eine erhebliche methodische Heterogenität hinsichtlich Studiendesign, Rekrutierungszeitpunkt, Messmethoden und untersuchter Substanzen.In nur 39 % der untersuchten Fälle korrelierten Veränderungen der Mikrozirkulation mit Veränderungen des Herzindex, was die begrenzte Aussagekraft makrohämodynamischer Parameter unterstreicht. Früh rekrutierte Patient:innen (< 24 h) zeigten häufiger eine Verbesserung der Mikrozirkulation und eine höhere hämodynamische Kohärenz. Norepinephrin verbesserte in frühen Krankheitsphasen die periphere Mikrozirkulation, ohne diese bei höheren MAP-Zielen konsistent zu verschlechtern. Vasopressin und Terlipressin zeigten kontextabhängige Effekte mit teils verbesserter sublingualer, aber potenziell verschlechterter gastraler Perfusion. Dobutamin war das am häufigsten untersuchte Inotropikum und zeigte in mehreren Studien eine Verbesserung der gastralen Mikrozirkulation, teilweise unabhängig von Veränderungen des Herzindex. Epinephrin wies inkonsistente Effekte auf, während Levosimendan in ausgewählten Studien sowohl die Myokardfunktion als auch mikrovaskuläre Parameter verbesserte.Der Review verdeutlicht, dass vasoaktive Medikamente relevante, jedoch hochgradig kontextabhängige Effekte auf die Mikrozirkulation haben. Die klinische Bedeutung dieser mikrovaskulären Veränderungen bleibt bislang unklar, da robuste Outcome-Daten fehlen. Zukünftige Forschung sollte standardisierte Messmethoden, frühe Rekrutierung, serielle Messungen und eine konsequente Einbettung des Konzepts der hämodynamischen Kohärenz verfolgen, um mikrozirkulationsgeleitete Resuscitationsstrategien evidenzbasiert weiterzuentwickeln.Heute im Studio dabei: Maximilian Kraft, wissenschaftlicher Mitarbeiter der Klinik für Anästhesiologie am UKHD

PerfWeb 109 – Day 2 features Joe Basha and Becky Bolkovac in a practical, honest conversation about what perfusion can be: a job, a vocation, a hobby, or a career—and how the way you frame your work impacts burnout, satisfaction, professionalism, and patient care. They break down the definitions, discuss real-world pressures like workload and call coverage, and explore why team culture and leadership matter—especially in high-stakes environments where the patient must always come first.

In this AJNR Fellows' Journal Club article summary, Dr. Francis Deng and Dr. Amir Khadivi discuss the article by Proner et al., "Impact of Clinical and Radiologic Factors on CTP Timing in Acute Ischemic Stroke." They discuss the authors' findings that cardiac arrhythmias and older age are independent predictors of nondiagnostic CTP exams. Specifically, these factors often lead to the truncation of reference vessel time-attenuation curves that fail to reach equilibrium within a 45-second acquisition window.

Aujourd'hui, Barbara Lefebvre, professeur d'histoire-géographie, Didier Giraud, agriculteur, et Yves Camdeborde, restaurateur, débattent de l'actualité autour d'Alain Marschall et Olivier Truchot.

PerfWeb 109 – Day 1 kicks off with a deep dive into how VR and AR are reshaping perfusion education. Host Joe Basha is joined by Vivian Moreno, Ed Delaney (Director, Perfusion Services, Northwell Health / Program Director, Hofstra), and Marty de Castro (Chief AI Scientist, VIRMEDEX). They break down how virtual simulation supports earlier clinical readiness, skill repetition, stress inoculation, and objective performance tracking—plus practical details on implementation, costs, and customization. The conversation closes with a look at what's next for VR-based training and where the technology may be headed.

PerfWeb 109 – Day 1 continues with a hands-on look at the “Anamotage Table” and how advanced 3D anatomy tools are transforming perfusion education. Host Joe Basha is joined by Ed Delaney (Director, Hofstra Cardiovascular Sciences & Perfusion Medicine / Northwell Health) and Vivian Moreno to explore how real-time cadaver-based visualization enhances anatomy, physiology, circuit planning, and board review. The discussion highlights how layered, interactive learning helps students connect anatomy to surgery, improves clinical readiness, and complements simulation training—while reinforcing professionalism, accountability, and lifelong learning in perfusion practice.

Shock can develop quickly in the backcountry, and recognizing it early can save a life. In this episode, we focus on how to identify shock with limited tools and how to tell the difference between its major types in remote settings. We break down cardiogenic, vasogenic, and hypovolemic shock using real-world backcountry scenarios, emphasizing observable signs, mental status changes, skin findings, and simple assessments you can perform in the field. The discussion highlights how understanding the type of shock can guide priorities such as bleeding control, positioning, insulation, and evacuation decisions when definitive care is hours—or days—away.

By Bram Duffee, PhD, EMT-P For EMS providers who respond to a traumatic cardiac arrest, the instinct to initiate CPR is almost automatic. But could this life-saving intervention inadvertently hinder recovery in cases of severe hemorrhagic shock? A recent study, “Effect of Cardiopulmonary Resuscitation on Perfusion in a Porcine Model of Severe Hemorrhagic Shock,” challenges conventional wisdom and offers new insights that could reshape trauma care protocols. The Study: A Closer Look at CPR in Trauma-Induced PEA The research, led by Dr. Patrick Greiffenstein, professor of clinical surgery at LSU New Orleans and trauma ICU director at the Norman McSwain Spirit of Charity Trauma Center, addresses a critical gap in trauma care. While CPR is a cornerstone of resuscitation in cardiac arrest, its application in trauma-induced pulseless electrical activity (PEA) has not been rigorously validated. Trauma PEA, unlike medical cardiac arrest, is a low-flow state caused by severe blood loss (hypovolemia), where the heart shows electrical activity but fails to generate a palpable pulse. “CPR is a cornerstone of resuscitation and cardiac arrest, but its application in trauma-induced PEA has not really been rigorously evaluated,” explains Dr. Greiffenstein. “Trauma PEA is fundamentally a low-flow state caused by hypovolemia—insufficient blood volume.” The study aimed to determine how CPR affects tissue perfusion—specifically oxygen delivery to the brain and skin—during severe hemorrhagic shock. Using a porcine model, researchers simulated life-threatening blood loss and compared outcomes between two groups: one receiving automated CPR and the other left untreated during the shock phase. Key Findings: When CPR May Do More Harm Than Good The results were both surprising and concerning: No Improvement in Perfusion: CPR did not enhance oxygenation in the brain or skin. In fact, skin perfusion was significantly lower in the CPR group during both the shock and recovery phases. Adverse Hemodynamic Effects: While CPR increased systolic blood pressure (SBP), it significantly reduced diastolic blood pressure (DBP), which is critical for coronary and organ perfusion. Potential Harm: CPR caused a threefold increase in intracranial pressure (ICP), suggesting that chest compressions might disrupt normal blood flow dynamics in the brain. “Knowing now that extreme efforts like lining people up to do CPR can cause turbulence within the system is a significant advancement,” says Dr. Greiffenstein. “It's possible to have perfusion at these unreadable MAP scores, which is a critical insight for trauma care.” Implications for Trauma Care These findings challenge the one-size-fits-all approach to CPR in cardiac arrest scenarios. In cases of hemorrhagic shock, CPR might: Divert attention from more effective interventions, such as rapid blood transfusion or surgical control of bleeding. Worsen perfusion to vital organs, potentially exacerbating the patient's condition. “In military cases, field medics often don't have the opportunity to perform full chest compressions on the battlefield. Sometimes, all they can do is drag a person to a safe position,” notes Dr. Greiffenstein. This study underscores the importance of prioritizing interventions that address the root cause of trauma PEA—severe blood loss—over traditional resuscitation techniques. A Call for Updated Guidelines The American Heart Association's current guidelines broadly recommend CPR for all pulseless patients. However, this study adds to a growing body of evidence suggesting that trauma-induced PEA requires a different approach. By focusing on restoring blood volume and controlling bleeding, paramedics and EMTs can improve outcomes for patients in hemorrhagic shock. As Dr. Greiffenstein puts it, “This research is a step toward more tailored and effective trauma care protocols. It's about understanding the unique physiology of trauma and adapting our interventions accordingly.” For EMS providers on the front lines, this study serves as a reminder to critically evaluate the tools and techniques we rely on in emergency care. While CPR remains a vital intervention in many scenarios, its role in trauma-induced PEA warrants careful reconsideration by physician medical directors. By staying informed about the latest research, we can continue to improve outcomes for the patients who depend on us most. Click below to watch the full interview Reference Greiffenstein, P., Cavalea, A., Smith, A., Sharp, T., Warren, O., Dennis, J., Gatterer, M. C., Danos, D., Byrne, T. C., Scarborough, A., Deville, P., & VanMeter, K. (2025). Effect of cardiopulmonary resuscitation on perfusion in a porcine model of severe hemorrhagic shock. The Journal of Trauma and Acute Care Surgery, 98(2), 251–257.      

Comment survivre à la perfusion numérique ? C'est le sujet de cette conférence. Elle a été donné dans le cadre d'une intervention au Lycée Notre-Dame La Merci à Montpellier. Pour rejoindre mon club de lecture Le Jardin

Dr. Ahmed Khalil is an MD-PhD currently serving his residency in radiology at the Institute of Neuroradiology at Charité University Hospital in Berlin. Originally from Sudan, he has been doing pioneering work on resting-state BOLD latency mapping, a technique that reveals flow deficits in the brain associated with stroke. His research demonstrates that this approach compares favorably with the current clinical gold standard of dynamic susceptibility contrast imaging using gadolinium, while capturing useful data in as little as two minutes.In this episode, Peter and Ahmed discuss his work translating advanced MRI techniques into clinical practice. They explore how BOLD latency mapping can detect perfusion deficits and compare with both traditional gadolinium-based methods and DTI for identifying stroke lesions. The conversation delves into the broader challenge faced by all promising research methods: what does it actually take to move from successful proof-of-concept to daily clinical practice on scanners around the world?Ahmed and Peter also talk about the cultural gap between research-level image processing and the clinical preference for minimally processed, interpretable data and how AI might help bridge that divide. Along the way, Ahmed shares valuable advice for MD-PhD students on the importance of collaboration, learning from diverse experts, and maintaining curiosity across disciplines.We hope you enjoy this episode!Chapters:00:00 - Introduction to Ahmed Khalil and His Work05:02 - Journey into Medicine and Radiology12:10 - The Challenges of Methods Development in Clinical Applications22:15 - Research on Resting State BOLD Latency37:27 - Clinical Implications of Perfusion Imaging in Stroke43:52 - Challenges in Clinical Implementation of New Imaging Techniques47:50 - The Role of AI in Radiology and Imaging Interpretation52:42 - Future Aspirations and Research Directions in Imaging01:01:03 - Collaborative Efforts in Physiologic MRI Book Project01:03:25 - Advice for Aspiring MD-PhD StudentsWorks mentioned:22:48 - https://pubmed.ncbi.nlm.nih.gov/23378326/(Lv et al., 2013 - First paper showing BOLD delay in stroke with Arno Villinger)23:08 - https://www.ahajournals.org/doi/10.1161/STROKEAHA.116.015566(Khalil et al., 2017 - Stroke paper, Relationship between BOLD delay and DSC-MRI)23:08 - https://pubmed.ncbi.nlm.nih.gov/30334657/(Khalil et al., 2018 - JCBFM paper, Longitudinal changes in BOLD delay)39:00 - https://pubmed.ncbi.nlm.nih.gov/34323339/(Hu et al., 2021 - Human Brain Mapping paper with Daniel Margulies - ICA approach)Episode producers:Ömer Faruk Gülban, Xuqian Michelle Li

Explore Harlequin Syndrome — differential hypoxemia seen in peripheral VA-ECMO and complex cardiopulmonary bypass cases — in this in-depth perfusion podcast. We define the hemodynamic and respiratory mechanisms behind the syndrome, review monitoring cues, and outline evidence-based approaches to diagnosis and correction. Designed for perfusionists, intensivists, and ECMO teams seeking clarity on a nuanced but critical clinical issue.

The ethics of NRP—current debates, consent, legal/organizational policies, and team communication. Hemodynamic monitoring for the perfusionist—MAP/PPV/SVV, venous oximetry, lactate trends, and practical targets on CPB and ECMO. Learning objectives: Identify the core ethical concerns and guardrails for NRP programs. Build an explicit consent and documentation pathway with the OR/NRP team. Apply a monitoring bundle (flows, pressures, SvO₂, lactate, urine output) to guide decisions. Create checklists for escalation, troubleshooting, and handoff.

Focus: practical ECMO circuit design and live simulations covering configuration choices, tubing and oxygenator selection, flow targets, pressure monitoring, recirculation prevention, anticoagulation, and troubleshooting. Learning objectives: • Build safe ECMO circuits step-by-step. Choose pumps, oxygenators, and tubing to meet patient goals. Set and adjust flow, sweep, and pressures during simulation. Prevent and correct recirculation, chatter, and alarms.

Happy Holidays its our holiday episode recorded live at Pefusion, Miricle pop up in Newtown with guests Melissa Sheketoff, Martin Santas head elf and Anna Zap from the Anna and Raven show!

Topics: From underflow to leaving suckers on during protamine—risk, mechanism, and management. IABP and Impella—patient selection, timing, and weaning strategy. Learning objectives: Recognize perfusion errors around protamine reversal and how to prevent them. Apply a stepwise strategy when flows are low or suckers remain on. Compare IABP and Impella indications, contraindications, and outcomes. Build practical checklists for OR communication and handoff.

When should you use albumin versus crystalloid during cardiopulmonary bypass? This PerfWeb session provides a clear, evidence-informed look at the clinical decision-making behind fluid selection in perfusion. Rather than focusing on which fluid is "better," this webinar explores the indications, physiological impact, and outcome-based reasoning for using albumin or crystalloid in different perfusion scenarios. Ideal for practicing perfusionists, board prep students, and cardiac care professionals, this session offers the clarity needed to make confident fluid choices during bypass and other critical procedures.

This episode examines the foundations of cardiopulmonary bypass, focusing on the 2024 EACTS/EACTAIC/EBCP Guidelines on cardiopulmonary bypass in adult cardiac surgery & the EBCP Expert consensus statement on basic qualifications and competencies for clinical perfusionists in Europe developed in collaboration with EACTS and EACTAIC. Joined by Alexander Wahba and Adrian Bauer, our hosts discuss what has evolved since the 2019 recommendations, where evidence has strengthened, and why practice still varies across Europe. The conversation covers pump technology, minimally invasive circuit strategies, key perfusion techniques, and the push to standardise perfusion education—highlighting how these documents aim to improve safety, consistency, and outcomes in everyday cardiac surgery.

”J'avais une révolte, une colère et de l'espoir à exprimer”François Ruffin est député de la Somme et candidat à la candidature pour les présidentielles de 2027.Avant les débats de l'hémicycle et les ambitions de pouvoir, il a passé 26 ans sur le terrain, à sillonner la France pour retranscrire le réel.Précurseur d'un journalisme plus authentique, il se met lui-même en scène dans différents formats pour son propre journal Fakir, à la radio, dans ses livres et reportages.En 2016, François publie “Merci Patron !”, un documentaire satirique dans lequel il défend une famille en détresse contre leur ancien employeur Bernard Arnault.Le succès de ce documentaire érige François en nouvelle figure de la gauche et lance véritablement sa carrière politique.En 2017 il crée son mouvement “Picardie Debout !”, fait campagne et devient député lors des législatives de juin.Je voulais recevoir François sur GDIY depuis de nombreuses années pour creuser cette facette “Do It Yourself” qu'il a et qui est de plus en plus rare chez les hommes/femmes politiques. Avoir une des têtes de la gauche était l'occasion d'aborder les sujets qui fâchent souvent, mais nous concernent tous :Pourquoi nos gouvernements ont tant de mal à réguler les dépenses publiques ?Quels doivent être les grands combats de la France pour les 5 prochaines années ?Peut-on être de gauche et être pro-business ?Ce que l'on risque si on ne reprend pas rapidement en main notre industrie ?François dresse le tableau d'un État perfusion qu'il est temps de repenser en profondeur.Une discussion à bâtons rompus avec un homme de convictions qui nous plonge en avance dans les grands sujets qui animeront le débat public jusqu'aux présidentielles.Vous pouvez suivre François sur Instagram et sur X.TIMELINE:00:03:00 : Pourquoi la gauche est si fâchée avec le business00:14:24 : Comment protéger les métiers qui portent la société00:22:48 : Arrêter d'opposer l'individu et le collectif00:28:53 : Mettre fin aux subventions aveugles00:38:55 : Le problème d'une société menée plus par le capital que par le travail00:45:10 : Exprimer sa révolte par le journalisme00:57:30 : Le gâchis productif qui tue la France de l'intérieur01:09:06 : Pourquoi l'IA n'est pas une priorité pour les politiques01:21:52 : L'urgence de reprendre en main notre industrie de défense01:32:25 : « J'aurais au moins vécu ça »Les anciens épisodes de GDIY mentionnés : #401 - Emmanuel Macron - Président de la République - Les décisions les plus lourdes se prennent seul#503 - Maxime Aiach - Acadomia, Shiva - Créer 2 millions d'emplois sans embaucher#420 - Stanislas Niox-Chateau - Doctolib : derrière la plus grosse marque de la French tech#500 - Reid Hoffman - LinkedIn, Paypal - Comment dompter l'invention la plus puissante de l'humanité#388 - Benoit Lemaignan - Verkor - “Pour avoir de l'impact climatique il faut aller vite et fort”Nous avons parlé de :Journal FakirLe documentaire “Merci Patron !”Le documentaire “J'veux du soleil”Le documentaire “Debout les femmes !”Le documentaire “Au boulot !”La bibliographie de FrançoisLa proposition de loi de François Ruffin sur les femmes de ménage “Encadrer la sous-traitance, cesser la maltraitance”Le CICE, Crédit d'Impôt pour la Compétitivité et l'EmploiLa levée de fonds éclair de DuralexJean TeuléDifférence entre le taux de chômage et le taux d'emploiCoffret DVD de tous les documentaires de François, produits avec Gilles PerretLa nouvelle gigafactory de Verkor à DunkerqueLa notion d'armée “bonzaï”Les recommandations de lecture :Mal-travail : Le choix des élites - François RuffinLeur progrès et le nôtre : De Prométhée à la 5G - François RuffinLa grande transformation - Karl PolanyiL'essentiel est invisible pour les yeux. Le Petit Prince - Antoine de Saint-ExupéryLes ritals - François CavannaDes souris et des hommes - John SteinbeckUn grand MERCI à nos sponsors : SquareSpace : squarespace.com/doitQonto: https://qonto.com/r/2i7tk9 Brevo: brevo.com/doit eToro: https://bit.ly/3GTSh0k Payfit: payfit.com Club Med : clubmed.frCuure : https://cuure.com/product-onelyVous souhaitez sponsoriser Génération Do It Yourself ou nous proposer un partenariat ?Contactez mon label Orso Media via ce formulaire.Hébergé par Audiomeans. Visitez audiomeans.fr/politique-de-confidentialite pour plus d'informations.

Invité :François Walraet, secrétaire général de la Coordination ruraleChroniqueurs :Alexandre Devecchio, rédacteur en chef du service débats du FigaroGeorges Fenech, ancien magistrat Hébergé par Audiomeans. Visitez audiomeans.fr/politique-de-confidentialite pour plus d'informations.

Perfusion as a specialty has always evolved in response to advances in cardiac surgery, extracorporeal support, and critical care. This session will explore how future perfusionists may need to redefine their role in healthcare teams. The discussion will focus on technology integration, including artificial intelligence, machine learning, and predictive analytics. Participants will consider how these tools may assist perfusionists in real-time decision-making, patient monitoring, and workflow efficiency. Additionally, the session will examine the professional challenges of the next decade: maintaining relevance within a multidisciplinary team, advancing educational pathways, and navigating ethical questions surrounding emerging technologies such as normothermic regional perfusion (NRP), mechanical circulatory support, and extracorporeal cardiopulmonary resuscitation (ECPR). Future perfusionists must be both technical experts and critical thinkers. They will need to master new tools while maintaining strong clinical judgment in life-saving scenarios. The speaker will also highlight career growth opportunities, including leadership roles in perfusion education, research, and hospital administration.

In this episode of BioTalk, CEO Gerard Eldering explains how Perfusion Medical is addressing a problem that trauma physicians and military medics have been struggling with for decades: capillary compression.  Perfusion Medical is developing a drug aimed at treating hemorrhagic shock and other ischemic conditions. PM‑208 is a novel IV therapeutic designed to restore capillary blood flow, resolve ischemia, and protect vital organs. The team has advanced this work with $19 million in Department of Defense funding. He describes the scale of the unmet need, why PM‑208 is both organ- and disease‑agnostic, and how its simple formulation and strong safety profile position it for broad medical use. Eldering also reflects on the company's path through the BioHealth Capital Region Crab Trap Competition. After a second‑place finish a few years earlier, Perfusion Medical returned to the stage and won the 2025 competition. He shares what that experience has meant for the team and why building the company in the BioHealth Capital Region—particularly from a Virginia base—has been a strategic advantage. The conversation moves through the role of early federal funding and programs like SBIR/STTR in de‑risking breakthrough therapies, and how university research partnerships have strengthened PM‑208's development. Eldering highlights how public‑private collaboration has shaped the company's progress and made it possible to push a complex medical solution toward patients more quickly.   Editing and post-production work for this episode was provided by The Podcast Consultant - https://thepodcastconsultant.com/0   About Gerard Eldering Gerard Eldering is the CEO of Perfusion Medical and a nationally recognized expert in technology transfer and venture formation. Since becoming an entrepreneur in 2007, he has helped launch more than a dozen startups, raised more than $15 million in seed funding, and led the turnaround and sale of a technology consulting firm. Before founding Perfusion Medical, he built and led The MITRE Corporation's Technology Transfer Office. Eldering is a U.S. Air Force veteran who served as a helicopter pilot and instructor. He holds a B.A. in Physics, an M.B.A., and is a registered patent agent.

Interview with Noemi Lois, MD, PhD, author of Retinal Sensitivity and Retinal Perfusion in Diabetic Retinopathy. Hosted by Neil Bressler, MD. Related Content: Retinal Sensitivity and Retinal Perfusion in Diabetic Retinopathy

Interview with Noemi Lois, MD, PhD, author of Retinal Sensitivity and Retinal Perfusion in Diabetic Retinopathy. Hosted by Neil Bressler, MD. An earlier posted version of this podcast may not have stated clearly enough that in areas with loss of perfusion and loss of sensitivity at baseline which remained non-perfused during the follow up, the sensitivity deficit declined over time. This has been corrected in the podcast. Related Content: Retinal Sensitivity and Retinal Perfusion in Diabetic Retinopathy

Liver transplantation continues to evolve as strategies expand to address organ shortage and optimize outcomes. Normothermic machine perfusion (NMP) offers a novel way to preserve and assess donor livers prior to implantation. In this episode of Behind the Knife, our transplant team at University of Nebraska Medical Center discusses the latest evidence from randomized trials, practical applications in donation after circulatory death (DCD) grafts, and how NMP is shaping clinical decision-making in high-risk transplants.  Hosts -  Madeline Cloonan, MD PhD, General Surgery Resident, University of Nebraska Medical Center, @maddie_cloonan   - Jacqueline Dauch, MD, Assistant Professor, University of Nebraska Medical Center  -  Shaheed Merani, MD PhD, Associate Professor, University of Nebraska Medical Center  - Alan Langnas, DO, Professor, University of Nebraska Medical Center  Learning Objectives - Describe the principles of normothermic machine perfusion (NMP) and how it differs from static cold storage.  - Summarize the design and key outcomes of the PROTECT trial and the Chapman et al. trial on NMP in liver transplantation.  - Recognize the clinical scenarios where NMP provides the greatest benefit, particularly in high-risk grafts (e.g., DCD donors, high donor risk index).  - Apply a practical viability assessment framework for livers on NMP, including hemodynamics, bile production, lactate trajectory, and histology when indicated.  - Discuss the implications of NMP for allocation, system logistics, and future adoption trends in transplantation.  References   1.     Markmann JF, Abouljoud MS, Ghobrial RM, et al. Impact of portable normothermic blood-based machine perfusion on outcomes of liver transplant: the OCS Liver PROTECT randomized clinical trial. JAMA Surg. 2022;157(3):189-198. doi:10.1001/jamasurg.2021.6781. https://pubmed.ncbi.nlm.nih.gov/34985503/ 2.     Chapman WC, Barbas AS, D'Alessandro AM, et al. Normothermic machine perfusion of donor livers for transplantation in the United States: a randomized controlled trial. Ann Surg. 2023;278(5):e912-e921. doi:10.1097/SLA.0000000000005934. https://pubmed.ncbi.nlm.nih.gov/37389552/ 3.     Nasralla D, Coussios CC, Mergental H, et al; Consortium for Organ Preservation in Europe. A randomized trial of normothermic preservation in liver transplantation. Nature. 2018;557(7703):50-56. doi:10.1038/s41586-018-0047-9. https://pubmed.ncbi.nlm.nih.gov/29670285/ 4.     Brubaker AL, Sellers MT, Abt PL, et al. US liver transplant outcomes after normothermic regional perfusion vs standard super rapid recovery. JAMA Surg. 2024;159(6):677-685. doi:10.1001/jamasurg.2024.0520. https://pubmed.ncbi.nlm.nih.gov/38568597/ 5.     Wall A, Snoddy M, Du J, et al. The current landscape of in situ and ex situ machine perfusion utilization for liver grafts from cardiac donation after circulatory death donors in the US. Am J Transplant. 2025;25(3):574-582. doi:10.1016/j.ajt.2024.09.012. https://pubmed.ncbi.nlm.nih.gov/39293517/ 6.     Watson CJE, Gaurav R, Fear C, Swift L, Selves L, Ceresa CDL, Upponi SS, Brais R, Allison M, Macdonald-Wallis C, Taylor R, Butler AJ. Predicting Early Allograft Function After Normothermic Machine Perfusion. Transplantation. 2022 Dec 1;106(12):2391-2398. doi: 10.1097/TP.0000000000004263. https://pubmed.ncbi.nlm.nih.gov/36044364/ 7.     Watson CJE, Hunt F, Messer S, Currie I, Large S, Sutherland A, Crick K, Wigmore SJ, Fear C, Cornateanu S, Randle LV, Terrace JD, Upponi S, Taylor R, Allen E, Butler AJ, Oniscu GC. In situ normothermic perfusion of livers in controlled circulatory death donation may prevent ischemic cholangiopathy and improve graft survival. Am J Transplant. 2019 Jun;19(6):1745-1758. doi: 10.1111/ajt.15241. https://pubmed.ncbi.nlm.nih.gov/30589499/ 8.     Olthoff KM, Kulik L, Samstein B, et al. Validation of a current definition of early allograft dysfunction in liver transplant recipients and analysis of risk factors. Liver Transpl. 2010;16(8):943-949. doi:10.1002/lt.22091.https://pubmed.ncbi.nlm.nih.gov/20677285/  9.     Kwong AJ, Kim WR, Lake JR, Schladt DP, Handarova D, Howell J, Schumacher B, Weiss S, Snyder JJ, Israni AK. OPTN/SRTR 2023 Annual Data Report: Liver. Am J Transplant. 2025 Feb;25(2S1):S193-S287. doi: 10.1016/j.ajt.2025.01.022. https://pubmed.ncbi.nlm.nih.gov/39947804/ Ad Disclosures: Visit goremedical.com/btk to learn more about GORE® ENFORM Biomaterial. Refer to Instructions for Use at eifu.goremedical.com for a complete description of all applicable indications, warnings, precautions and contraindications for the markets where this product is available. Rx only Please visit https://behindtheknife.org to access other high-yield surgical education podcasts, videos and more.   If you liked this episode, check out our recent episodes here: https://behindtheknife.org/listen Behind the Knife Premium: General Surgery Oral Board Review Course: https://behindtheknife.org/premium/general-surgery-oral-board-review Trauma Surgery Video Atlas: https://behindtheknife.org/premium/trauma-surgery-video-atlas Dominate Surgery: A High-Yield Guide to Your Surgery Clerkship: https://behindtheknife.org/premium/dominate-surgery-a-high-yield-guide-to-your-surgery-clerkship Dominate Surgery for APPs: A High-Yield Guide to Your Surgery Rotation: https://behindtheknife.org/premium/dominate-surgery-for-apps-a-high-yield-guide-to-your-surgery-rotation Vascular Surgery Oral Board Review Course: https://behindtheknife.org/premium/vascular-surgery-oral-board-audio-review Colorectal Surgery Oral Board Review Course: https://behindtheknife.org/premium/colorectal-surgery-oral-board-audio-review Surgical Oncology Oral Board Review Course: https://behindtheknife.org/premium/surgical-oncology-oral-board-audio-review Cardiothoracic Oral Board Review Course: https://behindtheknife.org/premium/cardiothoracic-surgery-oral-board-audio-review Download our App: Apple App Store: https://apps.apple.com/us/app/behind-the-knife/id1672420049 Android/Google Play: https://play.google.com/store/apps/details?id=com.btk.app&hl=en_US

PerfWeb 105 Day 2 focuses on the impact of hemoglobin on oxygen delivery (DO₂), a fundamental concept in perfusion practice. This session examines the relationship between hemoglobin concentration and systemic oxygen transport, with direct implications for patient safety and clinical decision-making during cardiopulmonary bypass. Designed for practicing perfusionists, board exam candidates, and healthcare professionals, the program blends theory with real-world applications in perfusion. Learning Highlights: The role of hemoglobin in oxygen delivery (DO₂). Physiological principles behind oxygen transport, Strategies to optimize DO₂ during bypass, Clinical relevance of hemoglobin levels in perfusion outcomes.

This PerfWeb session focuses on perfusionist board exam preparation with a live Q&A panel of certified perfusionists. The faculty will answer challenging questions directly related to board certification, offering valuable insights for candidates preparing to enter the field. Additionally, the webinar examines the clinical application of ultrafiltration during cardiopulmonary bypass, highlighting its role in managing fluid status, balancing electrolytes, and reducing inflammatory mediators. Learning Highlights: Panel Q&A: Certified perfusionists answer board exam questions. Ultrafiltration in perfusion practice: clinical applications, Managing fluid balance and reducing inflammatory mediators

Aujourd'hui, Joëlle Dago-Serry, coach de vie, Mourad Boudjellal, éditeur de BD, et Jérôme Marty, médecin généraliste, débattent de l'actualité autour d'Alain Marschall et Olivier Truchot.

Staffing Crisis, and Accountability in Perfusion Practice.

Pour ce premier épisode de la saison 3 de Beau Voyage, nous avons le bonheur de recevoir Evane Haziza-Bonnamour, l'une des créatrices du génial magazine Voyage Voyage qui révolutionne l'art de voyager et que nous adorons chez BeauVoyage. Issue d'une famille d'agents de voyage depuis trois générations, Evane nous raconte comment elle et son associé Fabien ont osé créer leur propre magazine indépendant avec une philosophie bien particulière qui consiste à sortir des sentiers battus et redorer les lettres de noblesse du voyage.Dans cette conversation passionnante, Evane nous dévoile les coulisses de la création audacieuse d'un magazine indépendant dans un secteur en crise et leur concept unique qui mélange destinations pointues et authenticité locale. Elle revient sur le timing à la fois parfait et risqué de leur lancement juste avant le Covid, et nous explique comment ils osent publier des couvertures sombres sur la route de la soie quand tout le monde mise sur les plages grecques.Evane nous fait également découvrir les secrets de fabrication d'un numéro depuis l'inspiration jusqu'à la réalisation, l'art de voyager avec un enfant de trois ans avec pour destination favorite le Japon, ses galères de voyage les plus mémorables comme ce fameux mal des montagnes au Pérou qui l'a menée sous perfusion, ainsi que ses coups de cœur absolus tel que le Sri Lanka hors saison. Evane nous livre aussi ses astuces pour concilier vie de famille et voyages de quinze jours aux quatre coins du monde.Nous avons adoré enregistrer cet épisode avec Evane et espérons qu'il vous plaira tout autant.Merci d'être toujours plus nombreux à nous suivre et à nous écouter, belle écoute ! Hébergé par Acast. Visitez acast.com/privacy pour plus d'informations.

Z-BUF, Staffing Crisis, and Accountability in Perfusion Practice.

Putting To Rest The Idea That Ultrafiltration On CPB Causes Renal Failure.

 I went to work one day and died. A perfusionist's journey.

What if one of biotech's biggest production breakthroughs was hiding in plain sight? Not in a new gene or a wonder drug, but in the way we process and purify biologics.Perfusion technology, once dismissed as a pipedream in top biopharma boardrooms, is now quietly powering some of the industry's most efficient and productive manufacturing platforms. Yet, transforming perfusion from controversial buzzword to gold standard required timing, vision, and a willingness to break from tradition.In this episode, host David Brühlmann sits down with Jarno Robin, a bioprocessing pioneer whose 20+ year journey spans industry giants like Novo Nordisk, Sanofi, and Leo Pharma. Jarno has championed upstream continuous processes, including ATF and TFF, for decades, and now, as a leader at Sani Membranes, he's unleashing the next evolution: Vibro® Membrane Filtration, an innovation set to upend conventional wisdom about fouling, pressure loss, scalability, energy usage, and more.Here are three reasons you'll want to listen to Jarno's journey:Innovation Versus Industry Inertia: Behind every platform shift are years of resistance. Jarno recounts how timing, advocacy, and matching the right data with the right decision-makers finally made perfusion mainstream, even after company leaders proclaimed, “We will never ever run perfusion.”State-of-the-Art and the Next Frontier: ATF and TFF remain dominant, but their limitations, like membrane fouling, scale-up headaches, and high energy needs, are real. Jarno explains how Vibro® Membrane Filtration addresses these pain points with a radically new design, offering lower pressure loss, less fouling, higher cell densities, and surprisingly low energy consumption.Practical Wisdom for Bioprocess Developers: Should you always run a control in process development? How do you translate lab-scale wins to robust, money-earning production? Jarno shares counterintuitive advice based on decades of hands-on success and mistakes.Curious how you can optimize your process technology and sidestep costly pitfalls? Listen to this episode and discover how “timing is everything” in bioprocessing innovation and whether new filtration methods could help you leap ahead.Connect with Jarno Robin:LinkedIn: www.linkedin.com/in/jarno-robinWebsite: www.sanimembranes.comCurious about continuous processing challenges and breakthroughs? Don't miss these previous episodes.Episodes 39-40: Balancing Perfusion Process Development and Sustainability with Jochen SieckEpisodes 85-86: Bioprocess 4.0: Integrated Continuous Biomanufacturing with Massimo MorbidelliEpisodes 153-154: The Future of Bioprocessing: Industry 4.0, Digital Twins, and Continuous Manufacturing Strategies with Tiago MatosNext step:Book a free consultation to help you get started on any questions you may have about bioprocess development: https://bruehlmann-consulting.com/call

Weaning the fiO2 on VA ECMO. Is This Safe Practice?

When to Say Enough. The Difficulty of Recognizing Futility in the Patient on ECMO.

Join Jay Gunkelman, QEEGD (the man who has analyzed over 500,000 brain scans), and host Pete Jansons for another engaging NeuroNoodle Neurofeedback Podcast episode discussing neuroscience, psychology, mental health, and brain training.✅ Topic 1 Explained: Learn how brain temperature affects neurological functioning, cognition, and the risk of dysfunction at high core temperatures.✅ Topic 2 Deep Dive: We explore the controversial concept of “God frequencies” and the Schumann Resonances—natural earth-based electromagnetic frequencies often misused in marketing.✅ Topic 3 Insights: Jay shares fascinating EEG data from healing studies, showing entrainment between healer and subject using cross-frequency coupling and standing wave potentials.✅ Additional Topics:

Massive Hemorrhage of an ECMO Patients - Requiring Six Full MTP's

On this episode of JHLT: The Podcast, the Digital Media Editors invite first author Gaurav Sharma, PhD, MBA, from the University of Texas Southwestern Medical Center in Dallas. Dr. Sharma discusses his paper, “Metabolic and transcriptomic insights into temperature controlled hypothermic preservation of human donor hearts.” The discussion explores: How donor hearts not offered or declined for transplantation responded in hypothermic preservation versus conventional static cold storage Potentially beneficial genetic signatures yielded by TCHP versus cold storage The surprising response of energy stores in the hearts to the different storage environments How multi-omic approaches could be applied to other organs For the latest studies from JHLT, visit www.jhltonline.org/current, or, if you're an ISHLT member, access your Journal membership at www.ishlt.org/jhlt. Don't already get the Journal and want to read along? Join the International Society of Heart and Lung Transplantation at www.ishlt.org for a free subscription, or subscribe today at www.jhltonline.org.

With Edward Hulten, Brown University, Providence, and Islam Shatla, University of Kansas Medical Center, Kansas City, USA. Link to edi

Join us for a continuation of our conversation with perfusionist Jordan Brimhall and Brandon Lowe, RRT, NPS, lead ECMO specialist at Emory in Atlanta. We discuss multidisciplinary collaboration in pediatric ECMO programs. Hosts: Deanna Todd Tzanetos, MD, MSCI (Norton Children's/UofL) and Chris Knoll, MD (Phoenix Children's). Guests Jordan Brimhall MS, CPP, FPP (Phoenix Children's) Brandon Lowe, RRT, NPS (Emory) Editing/Production (Deanna Todd Tzanetos, MD, MSCI)

This session dives into innovative machine perfusion techniques, advanced perfusates, and logistics breakthroughs aimed at extending organ viability and improving transplant outcomes. Packed with real-world case studies, expert insights, and interactive Q&A, this focused 1.2‑CEU webinar spotlights how modern technology is revolutionizing the way donor organs are preserved, transported, and ultimately saved.

Everything you wanted to know about perfusion but were afraid to ask. Join us for a conversation with Jordan Brimhall, MS, CCP, FPP Chief Perfusionist at Phoenix Children's Hospital. We discuss what really happens in the OR and what intensivists should know and understand about cardiopulmonary bypass. Hosts: Deanna Todd Tzanetos, MD, MSCI Norton Children's/ U of Louisville and Chris Knoll, MD Phoenix Children's Editor/Producer: Deanna Todd Tzanetos

Send us a textThe simple ice pack - a staple in both human and veterinary medicine for reducing pain and swelling. But what if this common therapy has unexpected consequences for healing? Soft tissue surgeon Dr. Vanna Dickerson and veterinary student Gabriella Hansen join us to discuss their fascinating research on how ice packs affect blood flow in canine skin.For years, surgeons have cautioned against using ice after delicate skin procedures like flaps and grafts, believing it might compromise blood flow. However, this advice lacked scientific backing until now. Through precise measurements using laser speckle contrast imaging, Dr. Dickerson and Hansen discovered that ice application reduces skin perfusion by 10-15% compared to baseline - and surprisingly, in some dogs, blood flow remained decreased even 15 minutes after the ice was removed.This groundbreaking work confirms what many surgeons suspected but couldn't prove, giving veterinarians evidence-based guidance for post-operative care decisions. Dr. Dickerson and Hansen emphasize that ice remains valuable for pain control in most situations, but surgeons should exercise caution in cases where even small perfusion decreases could jeopardize healing. For pet owners, understanding these nuances helps explain why your veterinarian might specifically recommend for or against icing in different scenarios.Beyond the clinical findings, Dr. Dickerson and Hansen offer valuable insights for veterinary students interested in research, encouraging them to find mentors and emphasizing that meaningful studies don't require complex laboratory setups. Their work exemplifies how asking simple questions about everyday practices can lead to significant improvements in patient care. Listen now to discover how this common therapy affects your pet's healing and what questions still remain for future investigation.AJVR article: https://doi.org/10.2460/ajvr.25.01.0023INTERESTED IN SUBMITTING YOUR MANUSCRIPT TO JAVMA ® OR AJVR ® ? JAVMA ® : https://avma.org/JAVMAAuthors AJVR ® : https://avma.org/AJVRAuthorsFOLLOW US:JAVMA ® : Facebook: Journal of the American Veterinary Medical Association - JAVMA | Facebook Instagram: JAVMA (@avma_javma) • Instagram photos and videos Twitter: JAVMA (@AVMAJAVMA) / Twitter AJVR ® : Facebook: American Journal of Veterinary Research - AJVR | Facebook Instagram: AJVR (@ajvroa) • Instagram photos and videos Twitter: AJVR (@AJVROA) / Twitter JAVMA ® and AJVR ® LinkedIn: https://linkedin.com/company/avma-journals

In this concluding episode of our deep dive into miniaturized perfusion systems, we tackle the most challenging aspect: implementing meaningful process analytical technology (PAT) at microscale while keeping costs realistic for high-throughput applications.Tom Valentin, group leader at CSEM for Automated Sample Handling, continues sharing CSEM's pioneering work in automated sample handling, revealing both the breakthrough opportunities and stubborn technical barriers that define the current state of small-scale perfusion development.Critical insights you'll gain from this episode:The PAT miniaturization challenge is about more than size: While optical density sensors work reasonably well for microbial cultures, mammalian cell applications demand more sophisticated solutions. Tom explains why viable cell density remains the "holy grail"—and how promising technologies from companies like IMEC and Inspec are pushing the boundaries, though cost-effective 96-well implementation remains elusiveSmart compromises can unlock practical solutions: Tom reveals why the industry may need to accept hybrid approaches—real-time pH and DO monitoring combined with once-daily viable cell density sampling. He also explains the unique challenges of sensor positioning in shaking deep-well plates where liquid dynamics create measurement complexitiesPartnership models that actually work for biotech innovation: Beyond the technical discussion, Tom outlines CSEM's proven collaboration approaches, including how Innoswiss funding can provide 50% cost reduction for development projects and why their 70% proposal success rate makes them an attractive R&D partner for both startups and established pharma companiesDiscover how bioprocessing is evolving - from high-throughput screening to digital twins and continuous manufacturing- in these expert-led episodes.Episode 155: From Process Bottlenecks to Seamless Production: How Continuous Bioprocessing Changes EverythingEpisodes 153-154: The Future of Bioprocessing: Industry 4.0, Digital Twins, and Continuous Manufacturing Strategies with Tiago MatosEpisodes 85-86: Bioprocess 4.0: Integrated Continuous Biomanufacturing with Massimo MorbidelliEpisodes 73-74: Bead-Based Assays: The Power of High-Throughput Screening with Sebastian GiehringConnect with Tom Valentin:LinkedIn: www.linkedin.com/in/tom-valentin-5bb9091bWebsite: www.csem.ch/enEmail: thomas.valentin@csem.chNext step:Book a free consultation to help you get started on any questions you may have about bioprocessing analytics: https://bruehlmann-consulting.com/callDevelop bioprocessing technologies better, faster, at a fraction of the cost with our 1:1 Strategy Call: The quickest and easiest way to excel biotech technology development. Book your call at www.bruehlmann-consulting.com/call/Support the show

In bioprocess development, the ability to rapidly screen conditions and predict scale-up performance can mean the difference between a successful therapy launch and costly delays. Today's Smart Biotech Scientist episode features Tom Valentin from CSEM, who's pioneering revolutionary approaches to miniaturized perfusion systems that could transform how we develop biologics.Tom is a group leader at CSEM for Automated Sample Handling within the Life Sciences and Industry 4.0 business unit. As a mechanical and biomedical engineer, he brings a unique cross-disciplinary perspective to solving bioprocessing's most challenging miniaturization problems.What makes this conversation essential listening:96-deep-well plates are revolutionizing perfusion development: Tom reveals how CSEM's innovative fluidic lids enable continuous medium exchange in 300-microliter volumes, potentially allowing up to 96 parallel perfusion experiments with automated liquid handlers and shaker incubatorsThree critical barriers still need solving: Despite the promise, Tom identifies the key technical challenges that must be overcome: ultra-low flow rate liquid handling (imagine exchanging 300 μL over 24 hours), effective cell retention in miniaturized systems, and cost-effective real-time biomonitoring that fits within well plate constraintsThe future of process development is automated and intelligent: From pressure-over-liquid systems to advanced sensor integration, Tom outlines how companies can achieve near-autonomous perfusion screening—but warns that current sensing limitations mean viable cell density monitoring remains the "holy grail" of small-scale perfusionThis isn't just about smaller equipment—it's about fundamentally changing how we approach process development. If you're working in cell culture optimization, process scale-up, or bioprocess automation, Tom's insights reveal both the tremendous opportunities and practical realities of implementing next-generation perfusion systems.For biotech professionals, staying ahead means embracing these high-throughput, data-rich models, allowing smarter, faster, and more predictive process development for the therapies of tomorrow.Discover how bioprocessing is evolving - from high-throughput screening to digital twins and continuous manufacturing- in these expert-led episodes.Episode 155: From Process Bottlenecks to Seamless Production: How Continuous Bioprocessing Changes EverythingEpisodes 153-154: The Future of Bioprocessing: Industry 4.0, Digital Twins, and Continuous Manufacturing Strategies with Tiago MatosEpisodes 85-86: Bioprocess 4.0: Integrated Continuous Biomanufacturing with Massimo MorbidelliEpisodes 73-74: Bead-Based Assays: The Power of High-Throughput Screening with Sebastian GiehringConnect with Tom Valentin:LinkedIn: www.linkedin.com/in/tom-valentin-5bb9091bWebsite: www.csem.ch/enEmail: thomas.valentin@csem.chNext step:Book a free consultation to help you get started on any questions you may have about bioprocessing analytics: https://bruehlmann-consulting.com/callDevelop bioprocessing technologies better, faster, at a fraction of the cost with our 1:1 Strategy Call: The quickest and easiest way to excel biotech technology development. Book your call at www.bruehlmann-consulting.com/call/Support the show

Host Sotirios Evangelou, MD, FSCCT is joined by Gianluca Pontone, MD, PhD, FSCCT to explore the evolving role of stress cardiac CT perfusion, from its early limitations to today's advanced scanners capable of capturing dynamic myocardial perfusion in just a few beats. Together, they discuss how this technique helps quantify blood flow and identify hypoperfused regions with precision.